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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GMDS-KIF6 (FusionGDB2 ID:33461)

Fusion Gene Summary for GMDS-KIF6

Fusion gene summary

Fusion gene information	Fusion gene name: GMDS-KIF6
	Fusion gene ID: 33461
		Hgene	Tgene
	Gene symbol	GMDS	KIF6
	Gene ID	2762	221458
	Gene name	GDP-mannose 4,6-dehydratase	kinesin family member 6
	Synonyms	GMD\|SDR3E1	C6orf102\|dJ1043E3.1\|dJ137F1.4\|dJ188D3.1
	Cytomap	6p25.3	6p21.2
	Type of gene	protein-coding	protein-coding
	Description	GDP-mannose 4,6 dehydrataseGDP-D-mannose dehydrataseshort chain dehydrogenase/reductase family 3E, member 1	kinesin-like protein KIF6
	Modification date	20200313	20200313
	UniProtAcc	.	Q6ZMV9
	Ensembl transtripts involved in fusion gene	ENST00000380815, ENST00000467288, ENST00000530927,	ENST00000229913, ENST00000373213, ENST00000373215, ENST00000373216, ENST00000394362, ENST00000465719, ENST00000538893, ENST00000541946, ENST00000287152,
Fusion gene scores	* DoF score	28 X 19 X 15=7980	13 X 10 X 10=1300
	# samples	32	15
	** MAII score	log2(32/7980*10)=-4.64024493622235 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/1300*10)=-3.11547721741994 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GMDS [Title/Abstract] AND KIF6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GMDS(2245555)-KIF6(39688587), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GMDS	GO:0019673	GDP-mannose metabolic process	9525924
Hgene	GMDS	GO:0042351	'de novo' GDP-L-fucose biosynthetic process	9525924

Fusion gene breakpoints across GMDS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KIF6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	CESC	TCGA-DG-A2KL-01A	GMDS	chr6	2245555	-	KIF6	chr6	39688587	-

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Fusion Gene ORF analysis for GMDS-KIF6

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000380815	ENST00000229913	GMDS	chr6	2245555	-	KIF6	chr6	39688587	-
5CDS-intron	ENST00000380815	ENST00000373213	GMDS	chr6	2245555	-	KIF6	chr6	39688587	-
5CDS-intron	ENST00000380815	ENST00000373215	GMDS	chr6	2245555	-	KIF6	chr6	39688587	-
5CDS-intron	ENST00000380815	ENST00000373216	GMDS	chr6	2245555	-	KIF6	chr6	39688587	-
5CDS-intron	ENST00000380815	ENST00000394362	GMDS	chr6	2245555	-	KIF6	chr6	39688587	-
5CDS-intron	ENST00000380815	ENST00000465719	GMDS	chr6	2245555	-	KIF6	chr6	39688587	-
5CDS-intron	ENST00000380815	ENST00000538893	GMDS	chr6	2245555	-	KIF6	chr6	39688587	-
5CDS-intron	ENST00000380815	ENST00000541946	GMDS	chr6	2245555	-	KIF6	chr6	39688587	-
In-frame	ENST00000380815	ENST00000287152	GMDS	chr6	2245555	-	KIF6	chr6	39688587	-
intron-3CDS	ENST00000467288	ENST00000287152	GMDS	chr6	2245555	-	KIF6	chr6	39688587	-
intron-3CDS	ENST00000530927	ENST00000287152	GMDS	chr6	2245555	-	KIF6	chr6	39688587	-
intron-intron	ENST00000467288	ENST00000229913	GMDS	chr6	2245555	-	KIF6	chr6	39688587	-
intron-intron	ENST00000467288	ENST00000373213	GMDS	chr6	2245555	-	KIF6	chr6	39688587	-
intron-intron	ENST00000467288	ENST00000373215	GMDS	chr6	2245555	-	KIF6	chr6	39688587	-
intron-intron	ENST00000467288	ENST00000373216	GMDS	chr6	2245555	-	KIF6	chr6	39688587	-
intron-intron	ENST00000467288	ENST00000394362	GMDS	chr6	2245555	-	KIF6	chr6	39688587	-
intron-intron	ENST00000467288	ENST00000465719	GMDS	chr6	2245555	-	KIF6	chr6	39688587	-
intron-intron	ENST00000467288	ENST00000538893	GMDS	chr6	2245555	-	KIF6	chr6	39688587	-
intron-intron	ENST00000467288	ENST00000541946	GMDS	chr6	2245555	-	KIF6	chr6	39688587	-
intron-intron	ENST00000530927	ENST00000229913	GMDS	chr6	2245555	-	KIF6	chr6	39688587	-
intron-intron	ENST00000530927	ENST00000373213	GMDS	chr6	2245555	-	KIF6	chr6	39688587	-
intron-intron	ENST00000530927	ENST00000373215	GMDS	chr6	2245555	-	KIF6	chr6	39688587	-
intron-intron	ENST00000530927	ENST00000373216	GMDS	chr6	2245555	-	KIF6	chr6	39688587	-
intron-intron	ENST00000530927	ENST00000394362	GMDS	chr6	2245555	-	KIF6	chr6	39688587	-
intron-intron	ENST00000530927	ENST00000465719	GMDS	chr6	2245555	-	KIF6	chr6	39688587	-
intron-intron	ENST00000530927	ENST00000538893	GMDS	chr6	2245555	-	KIF6	chr6	39688587	-
intron-intron	ENST00000530927	ENST00000541946	GMDS	chr6	2245555	-	KIF6	chr6	39688587	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000380815

GMDS

chr6

2245555

ENST00000287152

KIF6

chr6

39688587

9293

372

2750

902

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000380815	ENST00000287152	GMDS	chr6	2245555	-	KIF6	chr6	39688587	-	0.002141598	0.99785835

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Fusion Genomic Features for GMDS-KIF6

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GMDS-KIF6

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:2245555/chr6:39688587)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	KIF6 Q6ZMV9
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GMDS

chr6:2245555

chr6:39688587

ENST00000380815

30_35

373.0

Nucleotide binding

NADP

Tgene

KIF6

chr6:2245555

chr6:39688587

ENST00000229913

356_385

266.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KIF6

chr6:2245555

chr6:39688587

ENST00000229913

456_494

266.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KIF6

chr6:2245555

chr6:39688587

ENST00000229913

588_683

266.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KIF6

chr6:2245555

chr6:39688587

ENST00000287152

356_385

815.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KIF6

chr6:2245555

chr6:39688587

ENST00000287152

456_494

815.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KIF6

chr6:2245555

chr6:39688587

ENST00000287152

588_683

815.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KIF6

chr6:2245555

chr6:39688587

ENST00000373216

356_385

798.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KIF6

chr6:2245555

chr6:39688587

ENST00000373216

456_494

798.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KIF6

chr6:2245555

chr6:39688587

ENST00000373216

588_683

798.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KIF6

chr6:2245555

chr6:39688587

ENST00000229913

5_345

266.0

Domain

Kinesin motor

Tgene

KIF6

chr6:2245555

chr6:39688587

ENST00000229913

97_104

266.0

Nucleotide binding

ATP

Tgene

KIF6

chr6:2245555

chr6:39688587

ENST00000287152

97_104

815.0

Nucleotide binding

ATP

Tgene

KIF6

chr6:2245555

chr6:39688587

ENST00000373216

97_104

798.0

Nucleotide binding

ATP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GMDS

chr6:2245555

chr6:39688587

ENST00000380815

108_112

373.0

Nucleotide binding

NADP

Hgene

GMDS

chr6:2245555

chr6:39688587

ENST00000380815

55_58

373.0

Nucleotide binding

NADP

Hgene

GMDS

chr6:2245555

chr6:39688587

ENST00000380815

86_87

373.0

Nucleotide binding

NADP

Hgene

GMDS

chr6:2245555

chr6:39688587

ENST00000530927

108_112

343.0

Nucleotide binding

NADP

Hgene

GMDS

chr6:2245555

chr6:39688587

ENST00000530927

30_35

343.0

Nucleotide binding

NADP

Hgene

GMDS

chr6:2245555

chr6:39688587

ENST00000530927

55_58

343.0

Nucleotide binding

NADP

Hgene

GMDS

chr6:2245555

chr6:39688587

ENST00000530927

86_87

343.0

Nucleotide binding

NADP

Tgene

KIF6

chr6:2245555

chr6:39688587

ENST00000287152

5_345

815.0

Domain

Kinesin motor

Tgene

KIF6

chr6:2245555

chr6:39688587

ENST00000373216

5_345

798.0

Domain

Kinesin motor

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Fusion Gene Sequence for GMDS-KIF6

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>33461_33461_1_GMDS-KIF6_GMDS_chr6_2245555_ENST00000380815_KIF6_chr6_39688587_ENST00000287152_length(transcript)=9293nt_BP=372nt
GACGCGAATGACGCTGCGCCAGTCAGGCCGCAGCCCCGCTGCTTGGCCCGTCGGGCCCGCCTTGGCCGGCTCGGCCCGCCCCCGGCCCTC
CCTGCACGGCCTCCCGTGCGCCCCTGTCAGACTGTGGCGGCCGGTCGCGCGGTGCGCTCTCCCTCCCTGCCCGCAGCCTGGAGAGGCGCT
TCGTGCTGCACACCCCCGCGTTCCTGCCGGCACCGCGCCTGCCCTCTGCCGCGCTCCGCCCTGCCGCCGACCGCACGCCCGCCGCGGGAC
ATGGCACACGCACCGGCACGCTGCCCCAGCGCCCGGGGCTCCGGGGACGGCGAGATGGGCAAGCCCAGGAACGTGGCGCTCATCACCGGT
ATCACAGGCCAGATTTATTCCATAGATGAAGATGAAAAATTAATACCTAGCTTGGAAATCATCTTACCACGTGATTTGGCAGATGGGTTT
GTGAATAATAAGCGAGAAAGCTACAAATTTAAATTTCAAAGAATTTTTGATCAGGATGCAAACCAAGAGACCGTTTTTGAAAACATTGCC
AAACCAGTTGCTGGGAGTGTCCTGGCAGGTTACAATGGTACCATCTTTGCATATGGGCAAACAGGCAGCGGGAAGACATTCACTATCACA
GGGGGTGCAGAGCGTTACAGTGACAGAGGCATTATCCCAAGGACACTGTCATACATTTTTGAACAGTTACAAAAGGACAGCAGCAAAATA
TATACAACACACATTTCCTATTTGGAAATCTACAATGAATGTGGTTATGATCTTTTGGATCCAAGACATGAAGCCTCCAGTTTGGAAGAT
TTGCCGAAAGTGACAATACTGGAGGATCCTGATCAGAACATTCACCTGAAAAACTTGACTCTCCATCAGGCAACCACAGAGGAAGAAGCT
CTGAATTTGCTTTTTTTAGGAGACACCAACCGAATGATTGCAGAGACTCCTATGAACCAAGCTTCAACCCGTTCCCACTGCATTTTCACC
ATTCATTTGTCAAGCAAGGAACCAGGATCTGCAACTGTACGACATGCCAAACTCCATCTGGTTGACCTGGCTGGTTCAGAGCGAGTTGCA
AAGACTGGAGTAGGGGGCCATCTTCTAACAGAGGCCAAGTATATCAACTTGTCACTACATTACTTAGAACAGGTTATCATTGCCCTTTCA
GAAAAGCACCGTTCGCACATTCCTTATAGAAACTCCATGATGACCAGTGTCCTAAGAGACAGTTTGGGAGGGAACTGCATGACAACTATG
ATTGCAACACTCTCCTTGGAGAAAAGGAATCTTGATGAGTCTATATCAACCTGCAGATTTGCACAGCGAGTGGCACTCATAAAGAATGAA
GCTGTTCTTAATGAAGAAATTAACCCCAGATTAGTGATTAAACGCCTACAAAAGGAAATCCAGGAACTGAAGGATGAACTGGCCATGGTC
ACTGGGGAGCAGAGGACAGAGGCACTCACAGAAGCAGAGCTCCTTCAGCTGGAAAAACTAATAACATCCTTTTTGGAAGACCAGGATTCA
GACAGTAGATTAGAGGTTGGCGCGGATATGCGTAAAGTTCATCACTGTTTTCATCATTTAAAGAAACTATTGAATGACAAGAAGATCCTT
GAAAACAATACAGTCTCCTCTGAAAGCAAAGACCAAGATTGTCAAGAACCATTAAAAGAAGAAGAATATAGAAAGCTACGAGATATTCTG
AAACAGAGAGATAACGAAATCAATATCCTGGTCAACATGTTAAAAAAAGAAAAGAAGAAAGCTCAGGAGGCTCTCCACTTGGCTGGCATG
GATAGACGTGAATTCAGACAGTCCCAGAGCCCACCCTTCCGCCTAGGAAACCCAGAAGAAGGTCAAAGAATGCGACTATCCTCAGCTCCC
TCACAGGCCCAGGACTTCAGCATTTTGGGGAAAAGATCCAGTTTGCTCCACAAGAAAATAGGAATGAGAGAGGAAATGTCATTAGGATGC
CAGGAGGCTTTTGAAATCTTCAAGAGGGACCACGCTGACAGCGTTACCATCGATGACAACAAACAGATTCTGAAACAGAGATTTTCTGAA
GCCAAGGCCCTGGGAGAAAGTATAAATGAAGCAAGAAGTAAAATTGGTCACCTGAAGGAAGAAATCACCCAGCGGCATATACAGCAAGTA
GCCCTAGGAATCTCGGAAAACATGGCCGTGCCTCTGATGCCAGACCAGCAGGAGGAGAAGCTGCGATCACAACTGGAGGAAGAAAAGAGA
AGGTATAAAACAATGTTCACTCGCCTGAAAGCCCTGAAGGTGGAGATCGAGCACTTGCAGCTGCTCATGGACAAAGCCAAGGTGAAGCTA
CAGAAAGAGTTTGAAGTCTGGTGGGCAGAGGAGGCCACCAACCTGCAGGTAAATTCTCCAGCAGTGAATTCACTCGATCACACGAAGCCA
TTTCTCCAGACATCTGACTCCCAGCATGAATGGTCCCAACTCCTCTCTAACAAAAGTTCTGGAGGCTGGGAAGTCCAAGATCAAGGCACT
GGCAGATTCGATGTCTGTGATGTGAATGCCAGGAAAATCCTGCCCTCGCCTTGCCCCAGTCCACACAGCCAGAAACAGAGCAGCACCAGC
ACCCCACTGGAAGACAGCATCCCCAAGAGGCCAGTGTCGTCCATCCCTCTCACCGGAGACAGCCAGACGGACTCGGACATCATCGCCTTC
ATCAAGGCCAGACAGAGCATTCTGCAGAAGCAATGTTTGGGAAGCAATTGAATTTCCAGGAAATATCCATCCATGAATTATGCCAGCAAG
AATGAAGCACAGATGAAGGCAGCGCCCCTCACTTGCTCTGGCTTCAGAAGTGAACTATGGGCTGCTGGGAGCAACTAGTGACTTTGATTC
CCATGGAGGGGACTGTGTTTCTTTAAGGATGCTGACCTGGAGGCCACCGAGAGGCTGGGGCTGGGGCTGACCACAACATCCTTCCTGTGG
TTGCTGGAGCTGCTGGCAGGGCCAGGCAAGGCCAGAGTGCTAGGGGCAGGGTGAAGGCTTCAGCTCACTGTTGTAGTGACGTTTTGTGTA
GATCTTTATAAGCTTTTGAGAATGTGAAATAGCACCATCAAAATATAATGTCAGAGGATGCTCACACCAGTGGAATGTGGGGGGAATATT
TTTATTTTTAACGATTTGCCAGCTCTCTCCCTTGGCCCGTGCTCTGGTTTGGAAGCCCAGAAATGGCCATGACAGGTCCAGGCAGGATGT
CCCAGCCACAGGCAAGGCAGTGGAATGCAGGGCATCCTGAAGGCCAATCCTGATCTCCCAGACCACATCTTTCACCATCAGCCTCTTGGC
CAGGATGACCTGGAGGCAGTGCCTGAACAGCTGTGTCTCCAGGGAGCCATCTGCCCTGCAGGGTCTAAGGACATCATAGCACCCAGAGAA
CAGTGGGCAGCTCCCAGGGGCTCTGCTGAGAGCTTGAGAGAGGGCAGTGTGGGTACCTTGGGCCTCACAACCTTCACCCAGCCACTTGGG
AGGATTTGGGCTGACACTCCCCACTTCCACAGGGAAAAACATAGCTGCCTGGGGGTCTTGTCTCCATGGGCCCTCTCCATGACAGATCCA
AGGGAAGGTGGGCAGCCCTCAAGGAGGTTCTTGAAGAACTGCCCCCTGGGCCAGGGGGTTCCAACCCAGCTGCAGCCAGGGAGGGGCAGC
GGAGGGTGAGCAGGAGTGGCACCTGGAAATGAAGCTAACTGGATAAAAGTGCTGGTCCACTGCTCCTGGTGTCTCTGTCCTATAAATACA
GGACCTGATGACCCTGGAGGGGAGCAGAGTGGTAATATAGTATAATTGGCTTGATTTTCTTTTTCGTTTTTTAGGACTGGGTAACAGGAT
CATGCAGGAGAAGATTAAACCATTACATTTCTAAGCTAGGCAGGCCCATCGAGCTCCTCTAATCCACACCCCTATTTTATATAATTAGAA
GGCCAGAGTGAAGGGGAGATTCAGCTTGCTGTTCTATGCCACTGACAAATGTCCCCTCTTCAGGGGGCTTCCCCTGACCACTCCATCTCG
AGTCACCCCCTAGTTATCCCCTATCCCATTACCATTTTTTCTGCATCACTATCTGACATGTTATCCTTCCGAACTTGCCTATTTTTGAAA
TACCTGCAACCCCCCATAATACTAAGAGCTCCAATGCAACAGGGACCTGTTTGTCTTGCTCATTGCTGTGTCCCAAGCACAGAGTCGCTG
TTCAGTAAACGGTCCTTCAGTTCATGAGTAGACGAGCCAGAACCCAGATGTGTTTCTCAGGCTGGTGTCACTCTGACTTCCCCCAGGCTC
TGACTGAATCCCATCGGGACAGGGGCCAGCATCTCTGGTCCACTCCTGGCCCTCACAGTTCAATGGAACATAGTAAGCCCTCTGTAAAGT
CTGTAGAACCAGAGGAAGACCAAATTCTGATTCTAGAAGCCTCCCCAAGAGTCCATGGAACACACATGTAACTGCACACACACACACACA
TACACACACACACTCTCAAGAGCCCTGAAGATGGCATGGCATTTGCCCCAGTCCCCTATGTAGCAGCAGCAGTATTCTTGGCATGCCTTA
GTGCCCTCAGCCCTCTAGAGCTGGGTAGAGTCTACTAACTTTTATTTTCTTTTATTTTTACTTTCTTTTATTTATTTTTTGAGATGGGGG
GGGTCTCTGTCAGCCAGGCTGGGGTGCAGTGGTGCGACCATACCTCACTAGTCAGCCTCCAACTCCTGGGCTCAAGCCATACTCAGCCTC
CAACTCCTGGGCTCAAGCGATCCTCTCACCTCAGCCTCCAAAGTAGCTGGAACTACAGGCATGCACCACCACACCTAGCTCGTTTTAAAT
TTTTTGTAGAGACAGGGTCTCACTGTGTGGCTCAGGATGGTCTCAAATTCCTGGCCTTAAGCGATGCTCCCGCCTTGGCCTCCCAAAGTG
CTGGGATTGCAGGCATGAGCCACATACCCTGCCAGAGTCTTTCAACATTAGATCTCCCACTGAGACATCATCTCCTGGATCCAAAGGCCT
TACTGACAGAGATGTGTGGCATGGCCCCATGCGGGGTGTGAACCAGCCTCCTGGGGCAATCACTAAGACAGGAAAGGAAATGAAGACAGA
AAAACACACAACATGGGATCTGGGGCCACTGGTGTCCAGAGCATATGCAAAGTGTGTGCAGCAACTGGCCAAGGGGCCTTTTGCTCCGAA
CATCCCCTAATGGAAGCCCAGCCTTTGATATGGACACATGCTTGACAGCAGTGCACCTTCCCAGAGTTCACTGGCCTCTGCAAATGGGAG
AAATTGATGCAATGTTTTGAAAAGACTTTCCAGCAATCCACCTGGGATCAGTGGAGCCACGGATGACAAGAAGTATCTGAGTTCACTCTA
GGCCAAAATGTGGGATTTTCAAAAACATTTTCTGGAAAGCAGCCTAGCCAGTGACTCCAGCCCAGTCCCTGCTAGAATTCAACTGGCTCT
ACCAATCCCTTGACAAGAAGTAGGGTGGACGGAGGTTGGAGGAGGGAAGTTAAAATGTAGCTTGCCCAGATCTTGCTAAAAAGGAGTTTT
AGAAAGCAGATAGAGAAATTGTGGTATACTGAATACATCATTTTAATTCTTCACCACCAGTATAGAATTACACATCCAAAGCTTTGTCAT
GGCCCACTTTGACTAATGTGGTGTTGGCAAACCTGATCCAGGCAGAGGCTTGAATTGTGCTCTCATGGTTGAGCTTGCCTCTTGCTCCAG
TGATCTCTCTTGGGATGAACATGCCATGGGTAGCTGCTGCCCCTTCAGCCTGGAACATCCAGAGAGCAGACCTGAGCCCAGTCTACAGCC
TGGAGCAGAGCCTCCCAGGCAAGCCCAGCCCAGATCAGCTGAACTATGGCTCACCCAAAGACCTATTGGCATGAGAATATATGCTGCTTG
TCATAAACCACTGAGGTTTAGAGTGGTTTGTTATATAGCATTAATTGTAGCAATAGCAGACTGGCACAGAAATTGGAACCCAGAGACAGT
ATATGACTGGATCTAGGATTTCTCAGTGCAGAGTTCATTGTCTCTCCATGCAGCCTGTGGAAAGGCACTGAGAGCATCCTGTATATGGAA
AAGCAGGACCACCACCTACAGCCATGATGAAGCAACAAGGACCTGATTTACCCTCCTGCTTTAAATGACTAAAAATGAGACAAAATCCTC
TATACAAACCAATGGTTTTCAGCCATTGGATAACAAGCAATATAGGGTATGATTGATCCGCAAGAGAAGGGAAACAAGTGAGGGGAGCCC
TATGATTGCTCCAACTTACTGCCTGCAGTGAGTTTTCAGGCTGCAGCCCAGGAAGGGGGAACCAGGTAGAGCCCAGTGGTTTCCCTGAGT
TGAGGAAATGGAGCTGGGAATCCAGGGAGGACAAAGTGGCTTAAATTTGCAAGGCAGAGTCCCAGGGATGAGAGAGAGAGAAGGAGAGAG
AGAGGAGAAAAAAGAGAGAGAAAGAGAGAGAGCATGCTCTGGAGATCTTCAGAGGGTTACCCTTGAGTCTTCAGCTAACTACCGATCAAC
ATCTGCATGTGAAGAAATTACCCAAGGCAGGGGAAAGAACCACCAGGAGGAAGCAGGTGGAATAATTTCCTGAGATAACACTGTGTTGGG
AAGAGTTCATGTTTCCAACAGCCAGAGTGGAGAAACCTCCCAAAACAGTCATTGTATAGAGACACATAAGGTACTGCCTCAGAAGTGGGG
CCAAATTAGTCCTAGATGATAGATTGCTCTGGTCCCACCTAACAAAGCTTAAAAAGCCAGCCCCAAAGGAGTCAAATTGTTTCCAGTAAG
TTTCCAAGTAACTTCAATGAGTCCCAAAACAAAGCTTCAAAATATCTAAAGGAATATGAAAAACAAACCAAAAAGAAACCAGCATCCAAC
AATATAGAATCCACAATGTCTGGTGTCCATTAAAAAATAATCAGGCATGCAAAGAAGCAGGAAAATATGGGCCATGAGAGGAGAAAAAAC
CATCAATAGAAATAGAGGCCGGGTGTGGTGGCTCACTCCTATAATCCCAGCACTTTGGGAGGCCGAGGCAGGAGGATCACCTGAGGTCAG
GAGTTCAAGAACAGCCTGTTCAACATGGGGAAACCCCGTCTCTACTAAAAATACAAAAAATAGCCGGGCATGGTGTTGCGTACCTGTAAT
CCCAGCTACTCAGAGGCTGAGGCAGGAGAATTGCTTGAGCCCAGGAGGCAGAGGTTACAGTGAGCCGAAATTGTGCCATTGCACTCCAGC
TTGGGCAACAAGAGTGAAACTCTGTCTCAAAAAAAAAAAAAAGAAAAAACAAATAGAAACAGCCCCAGGCATGGCACAGTTGATAGAGTA
AATAGACAGAAACATTTTTTAAAATGCAATGGGTGTGTGTTTCAAATCTAGGCAGAAAAAATGCTCCTTGTAATTCCTTAAACATAAGCA
TGTCTCATTCATCTGGTCATTGTTTTGACAAGGATGTGCCATCCATTGTGCTAAGTTCTGAGGAGTCAGAGGTGACAGAGACAGAGAAAG
TGCCAGCATTCTTGGAACCTTCTAACGAAGGAGAGGGACAAGCCAGGCATGGTGGCTCACGCCTGTAATCCCAACACTTTGGGAGACTGA
GGCTGGCGGATCACGAGGTCAGGAGTTTGAGACCAACCTGGCCAACATGGCGAAACCCCATCGCTACTAAAAATACAAAAATTAGCTGGG
TGTGGTGGTGCGCACCTGTAATCCCAGCTACTCTGGAGGCTGAGGCAGGACAATCACTTGAACCCTGGAGGCAGAGTTTGCAGTGAGCTG
AGATCGTGCCACTGCACTCCAACCTGGGCAACAAGAGCGAGACTCCTTCTCTGAAAAAAAAAAAAAGAGAGGGACAATAAACAAGTAAGC
AAGACAATCTGATTAAGAAGGAGTTGGGGTTAGCTGGGCATGGTAGCAAGCGCCTGTAGTCTCAGCTACTCGGGAGGCTGAGGTGGGAGG
ATCCTTGAACCCAGGAGGTTAAGGCTGCAGTGAGCTGTGATCACACCACTGCACTCCAGCCTGGATGACAGAGCAAGACCCTGTCTCAGA
AAAAGAAGAAGGAGTTGGGGGTGGGGTAGGATGGGCTTGGACTCACTATCAAGGTGGGTGGGAGTGTGAGAACCCGGCAAGGTGCAAAGA
GAGAAGCAGGGAAGGGAAGCTTAGGACAATGATGGCAGGTTGGGTATTGGGTGATGGGAAGAGGCAAAGGACGTGGAGCTTGGCAAAAAG
GGGACTTGTGGGGATTTGGGCCATGTGAGCATGTGGGGGAGACAGTGTTCCTTCCATAACACGTGTCCAGGGACTGCCAGGGCTCCGAGG
CAGAGCAGGTGTAGAGAGGTTGGCTGTGAATGTTGGATGTTGAAAACATATGTGTCAAATGTGGGAGGAAAAAGCAGTGTTTCCTTGAAT
ACAAGCTCCTCCTCACCTTGCGAAAAGTGGCCTCTGAGTGTAGCCCTGAATGCATCTCCCAAGGAATAGGAGGAAGCAGCAACCTTTTCA
GAGTTAACTGCTTTATTTGGGTTTTCCATGGCCTCGTGCCAGCCAGCAGGGCTGAGCCAGTTTCACCCACACTGAGAGGGAACTCAGCAA
AGAGCAAGCAGCATGCCAGCTGGTACTCTTCCCTCTCCATTCACTCAGCTCCTGATCTCAGGAGGGCAGCCCCTCCCCAGGCCAGCACCC
CTCCCCTTCTGGCCCCAGGTGTGGGATGTTGTTGTTTTCTTTTCTCCGAAACATCTCCTGGGTTTGTCTTTTCCATCACTGTCTTTAGAC
TGAGGCAAGCAGTCCCCATGCCTTCAGCCCCATGTTTTGGGGGTAACCTGTGCTTTGACATGCTTTGCTAAAAACTTTCTAAGTCTCCCT
CTGGTGCTGGGACCAGCCATGACCAACAACGTCATCCATGCAGGCCACCCCTAACATAGTCCAGGCCTCATGTGGGTCTCAGTTCCCTTT
TCTTCTTTCAGGAAGTTCTCCAGTGCATGCATAGGGTTGACCAGATGTCCCAAGGTGCTCTAGGACTTATGCCTATGAAGCTGTTTTAGG
GCTTCCTAGTCAGTCCCTGGTTCCAGGAAAGCAGCCTGATGAGGAGATCATTCCCGCTGGCTGGTGTGGCATTTCTTTTATGGCACTACC
TGGGATTGGGCCACCAGACCTGCGCTAACATGCTGATTTGATGGACTCTTAACATCATAGGACAAAGAATCGTCATGTGAACCAATTAGA

>33461_33461_1_GMDS-KIF6_GMDS_chr6_2245555_ENST00000380815_KIF6_chr6_39688587_ENST00000287152_length(amino acids)=902AA_BP=109
MARRARLGRLGPPPALPARPPVRPCQTVAAGRAVRSPSLPAAWRGASCCTPPRSCRHRACPLPRSALPPTARPPRDMAHAPARCPSARGS
GDGEMGKPRNVALITGITGQIYSIDEDEKLIPSLEIILPRDLADGFVNNKRESYKFKFQRIFDQDANQETVFENIAKPVAGSVLAGYNGT
IFAYGQTGSGKTFTITGGAERYSDRGIIPRTLSYIFEQLQKDSSKIYTTHISYLEIYNECGYDLLDPRHEASSLEDLPKVTILEDPDQNI
HLKNLTLHQATTEEEALNLLFLGDTNRMIAETPMNQASTRSHCIFTIHLSSKEPGSATVRHAKLHLVDLAGSERVAKTGVGGHLLTEAKY
INLSLHYLEQVIIALSEKHRSHIPYRNSMMTSVLRDSLGGNCMTTMIATLSLEKRNLDESISTCRFAQRVALIKNEAVLNEEINPRLVIK
RLQKEIQELKDELAMVTGEQRTEALTEAELLQLEKLITSFLEDQDSDSRLEVGADMRKVHHCFHHLKKLLNDKKILENNTVSSESKDQDC
QEPLKEEEYRKLRDILKQRDNEINILVNMLKKEKKKAQEALHLAGMDRREFRQSQSPPFRLGNPEEGQRMRLSSAPSQAQDFSILGKRSS
LLHKKIGMREEMSLGCQEAFEIFKRDHADSVTIDDNKQILKQRFSEAKALGESINEARSKIGHLKEEITQRHIQQVALGISENMAVPLMP
DQQEEKLRSQLEEEKRRYKTMFTRLKALKVEIEHLQLLMDKAKVKLQKEFEVWWAEEATNLQVNSPAVNSLDHTKPFLQTSDSQHEWSQL
LSNKSSGGWEVQDQGTGRFDVCDVNARKILPSPCPSPHSQKQSSTSTPLEDSIPKRPVSSIPLTGDSQTDSDIIAFIKARQSILQKQCLG

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Top

Fusion Gene PPI Analysis for GMDS-KIF6

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GMDS-KIF6

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for GMDS-KIF6

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source