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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GMDS-MRPS18B (FusionGDB2 ID:33466)

Fusion Gene Summary for GMDS-MRPS18B

Fusion gene summary

Fusion gene information	Fusion gene name: GMDS-MRPS18B
	Fusion gene ID: 33466
		Hgene	Tgene
	Gene symbol	GMDS	MRPS18B
	Gene ID	2762	28973
	Gene name	GDP-mannose 4,6-dehydratase	mitochondrial ribosomal protein S18B
	Synonyms	GMD\|SDR3E1	C6orf14\|HSPC183\|HumanS18a\|MRP-S18-2\|MRPS18-2\|PTD017\|S18amt
	Cytomap	6p25.3	6p21.33
	Type of gene	protein-coding	protein-coding
	Description	GDP-mannose 4,6 dehydrataseGDP-D-mannose dehydrataseshort chain dehydrogenase/reductase family 3E, member 1	28S ribosomal protein S18b, mitochondrial28S ribosomal protein S18-2, mitochondrialMRP-S18-bS18mt-bmitochondrial ribosomal protein S18-2mitochondrial small ribosomal subunit protein bS18bmitochondrial small ribosomal subunit protein bS18m-Bmitochon
	Modification date	20200313	20200320
	UniProtAcc	.	Q9Y676
	Ensembl transtripts involved in fusion gene	ENST00000380815, ENST00000530927, ENST00000467288,	ENST00000418070, ENST00000472229, ENST00000472444, ENST00000489289, ENST00000259873, ENST00000327800, ENST00000400594, ENST00000412451, ENST00000412843, ENST00000426945, ENST00000428224, ENST00000430402, ENST00000437247, ENST00000440992, ENST00000451032, ENST00000454427, ENST00000468755, ENST00000469397, ENST00000477010, ENST00000493769, ENST00000506373,
Fusion gene scores	* DoF score	28 X 19 X 15=7980	5 X 9 X 4=180
	# samples	32	7
	** MAII score	log2(32/7980*10)=-4.64024493622235 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GMDS [Title/Abstract] AND MRPS18B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GMDS(1726650)-MRPS18B(30592660), # samples:1 GMDS(1726649)-MRPS18B(30590608), # samples:1 GMDS(1726650)-MRPS18B(1884247), # samples:1 GMDS(1726650)-MRPS18B(1922888), # samples:1 GMDS(1726650)-MRPS18B(30590609), # samples:1
Anticipated loss of major functional domain due to fusion event.	GMDS-MRPS18B seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. GMDS-MRPS18B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. GMDS-MRPS18B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GMDS	GO:0019673	GDP-mannose metabolic process	9525924
Hgene	GMDS	GO:0042351	'de novo' GDP-L-fucose biosynthetic process	9525924

Fusion gene breakpoints across GMDS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MRPS18B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-K4-A3WV-01A	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
ChimerDB4	BLCA	TCGA-K4-A3WV-01A	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
ChimerDB4	BLCA	TCGA-K4-A3WV-01A	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
ChimerDB4	BLCA	TCGA-K4-A3WV-01A	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
ChimerDB4	BLCA	TCGA-K4-A3WV	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+

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Fusion Gene ORF analysis for GMDS-MRPS18B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000380815	ENST00000418070	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-3UTR	ENST00000380815	ENST00000472229	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-3UTR	ENST00000380815	ENST00000472229	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-3UTR	ENST00000380815	ENST00000472229	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-3UTR	ENST00000380815	ENST00000472444	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-3UTR	ENST00000380815	ENST00000489289	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-3UTR	ENST00000530927	ENST00000418070	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-3UTR	ENST00000530927	ENST00000472229	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-3UTR	ENST00000530927	ENST00000472229	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-3UTR	ENST00000530927	ENST00000472229	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-3UTR	ENST00000530927	ENST00000472444	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-3UTR	ENST00000530927	ENST00000489289	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000380815	ENST00000259873	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000380815	ENST00000259873	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000380815	ENST00000327800	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000380815	ENST00000327800	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000380815	ENST00000327800	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000380815	ENST00000327800	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000380815	ENST00000327800	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000380815	ENST00000400594	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000380815	ENST00000400594	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000380815	ENST00000400594	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000380815	ENST00000400594	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000380815	ENST00000400594	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000380815	ENST00000412451	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000380815	ENST00000412451	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000380815	ENST00000412451	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000380815	ENST00000412451	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000380815	ENST00000412451	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000380815	ENST00000412843	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000380815	ENST00000412843	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000380815	ENST00000412843	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000380815	ENST00000412843	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000380815	ENST00000412843	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000380815	ENST00000418070	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000380815	ENST00000418070	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000380815	ENST00000418070	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000380815	ENST00000418070	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000380815	ENST00000426945	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000380815	ENST00000426945	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000380815	ENST00000426945	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000380815	ENST00000426945	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000380815	ENST00000426945	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000380815	ENST00000428224	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000380815	ENST00000428224	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000380815	ENST00000428224	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000380815	ENST00000428224	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000380815	ENST00000428224	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000380815	ENST00000430402	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000380815	ENST00000430402	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000380815	ENST00000430402	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000380815	ENST00000430402	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000380815	ENST00000430402	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000380815	ENST00000437247	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000380815	ENST00000437247	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000380815	ENST00000437247	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000380815	ENST00000437247	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000380815	ENST00000437247	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000380815	ENST00000440992	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000380815	ENST00000440992	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000380815	ENST00000440992	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000380815	ENST00000440992	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000380815	ENST00000440992	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000380815	ENST00000451032	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000380815	ENST00000451032	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000380815	ENST00000451032	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000380815	ENST00000451032	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000380815	ENST00000451032	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000380815	ENST00000454427	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000380815	ENST00000454427	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000380815	ENST00000454427	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000380815	ENST00000454427	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000380815	ENST00000454427	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000380815	ENST00000468755	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000380815	ENST00000468755	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000380815	ENST00000468755	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000380815	ENST00000468755	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000380815	ENST00000468755	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000380815	ENST00000469397	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000380815	ENST00000469397	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000380815	ENST00000469397	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000380815	ENST00000469397	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000380815	ENST00000469397	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000380815	ENST00000472229	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000380815	ENST00000472229	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000380815	ENST00000472444	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000380815	ENST00000472444	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000380815	ENST00000472444	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000380815	ENST00000472444	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000380815	ENST00000477010	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000380815	ENST00000477010	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000380815	ENST00000477010	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000380815	ENST00000477010	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000380815	ENST00000477010	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000380815	ENST00000489289	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000380815	ENST00000489289	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000380815	ENST00000489289	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000380815	ENST00000489289	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000380815	ENST00000493769	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000380815	ENST00000493769	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000380815	ENST00000493769	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000380815	ENST00000493769	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000380815	ENST00000493769	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000380815	ENST00000506373	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000380815	ENST00000506373	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000380815	ENST00000506373	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000380815	ENST00000506373	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000530927	ENST00000259873	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000530927	ENST00000259873	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000530927	ENST00000327800	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000530927	ENST00000327800	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000530927	ENST00000327800	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000530927	ENST00000327800	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000530927	ENST00000327800	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000530927	ENST00000400594	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000530927	ENST00000400594	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000530927	ENST00000400594	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000530927	ENST00000400594	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000530927	ENST00000400594	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000530927	ENST00000412451	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000530927	ENST00000412451	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000530927	ENST00000412451	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000530927	ENST00000412451	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000530927	ENST00000412451	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000530927	ENST00000412843	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000530927	ENST00000412843	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000530927	ENST00000412843	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000530927	ENST00000412843	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000530927	ENST00000412843	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000530927	ENST00000418070	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000530927	ENST00000418070	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000530927	ENST00000418070	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000530927	ENST00000418070	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000530927	ENST00000426945	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000530927	ENST00000426945	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000530927	ENST00000426945	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000530927	ENST00000426945	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000530927	ENST00000426945	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000530927	ENST00000428224	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000530927	ENST00000428224	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000530927	ENST00000428224	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000530927	ENST00000428224	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000530927	ENST00000428224	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000530927	ENST00000430402	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000530927	ENST00000430402	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000530927	ENST00000430402	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000530927	ENST00000430402	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000530927	ENST00000430402	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000530927	ENST00000437247	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000530927	ENST00000437247	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000530927	ENST00000437247	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000530927	ENST00000437247	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000530927	ENST00000437247	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000530927	ENST00000440992	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000530927	ENST00000440992	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000530927	ENST00000440992	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000530927	ENST00000440992	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000530927	ENST00000440992	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000530927	ENST00000451032	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000530927	ENST00000451032	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000530927	ENST00000451032	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000530927	ENST00000451032	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000530927	ENST00000451032	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000530927	ENST00000454427	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000530927	ENST00000454427	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000530927	ENST00000454427	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000530927	ENST00000454427	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000530927	ENST00000454427	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000530927	ENST00000468755	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000530927	ENST00000468755	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000530927	ENST00000468755	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000530927	ENST00000468755	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000530927	ENST00000468755	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000530927	ENST00000469397	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000530927	ENST00000469397	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000530927	ENST00000469397	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000530927	ENST00000469397	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000530927	ENST00000469397	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000530927	ENST00000472229	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000530927	ENST00000472229	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000530927	ENST00000472444	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000530927	ENST00000472444	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000530927	ENST00000472444	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000530927	ENST00000472444	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000530927	ENST00000477010	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000530927	ENST00000477010	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000530927	ENST00000477010	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000530927	ENST00000477010	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000530927	ENST00000477010	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000530927	ENST00000489289	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000530927	ENST00000489289	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000530927	ENST00000489289	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000530927	ENST00000489289	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000530927	ENST00000493769	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000530927	ENST00000493769	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
5CDS-intron	ENST00000530927	ENST00000493769	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000530927	ENST00000493769	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000530927	ENST00000493769	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
5CDS-intron	ENST00000530927	ENST00000506373	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
5CDS-intron	ENST00000530927	ENST00000506373	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
5CDS-intron	ENST00000530927	ENST00000506373	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
5CDS-intron	ENST00000530927	ENST00000506373	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
Frame-shift	ENST00000380815	ENST00000259873	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
Frame-shift	ENST00000530927	ENST00000259873	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
In-frame	ENST00000380815	ENST00000259873	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
In-frame	ENST00000380815	ENST00000259873	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
In-frame	ENST00000380815	ENST00000506373	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
In-frame	ENST00000530927	ENST00000259873	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
In-frame	ENST00000530927	ENST00000259873	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
In-frame	ENST00000530927	ENST00000506373	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
intron-3CDS	ENST00000467288	ENST00000259873	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
intron-3CDS	ENST00000467288	ENST00000259873	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
intron-3CDS	ENST00000467288	ENST00000259873	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
intron-3CDS	ENST00000467288	ENST00000506373	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
intron-3UTR	ENST00000467288	ENST00000418070	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
intron-3UTR	ENST00000467288	ENST00000472229	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
intron-3UTR	ENST00000467288	ENST00000472229	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
intron-3UTR	ENST00000467288	ENST00000472229	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
intron-3UTR	ENST00000467288	ENST00000472444	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
intron-3UTR	ENST00000467288	ENST00000489289	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
intron-intron	ENST00000467288	ENST00000259873	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
intron-intron	ENST00000467288	ENST00000259873	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
intron-intron	ENST00000467288	ENST00000327800	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
intron-intron	ENST00000467288	ENST00000327800	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
intron-intron	ENST00000467288	ENST00000327800	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
intron-intron	ENST00000467288	ENST00000327800	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
intron-intron	ENST00000467288	ENST00000327800	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
intron-intron	ENST00000467288	ENST00000400594	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
intron-intron	ENST00000467288	ENST00000400594	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
intron-intron	ENST00000467288	ENST00000400594	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
intron-intron	ENST00000467288	ENST00000400594	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
intron-intron	ENST00000467288	ENST00000400594	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
intron-intron	ENST00000467288	ENST00000412451	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
intron-intron	ENST00000467288	ENST00000412451	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
intron-intron	ENST00000467288	ENST00000412451	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
intron-intron	ENST00000467288	ENST00000412451	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
intron-intron	ENST00000467288	ENST00000412451	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
intron-intron	ENST00000467288	ENST00000412843	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
intron-intron	ENST00000467288	ENST00000412843	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
intron-intron	ENST00000467288	ENST00000412843	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
intron-intron	ENST00000467288	ENST00000412843	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
intron-intron	ENST00000467288	ENST00000412843	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
intron-intron	ENST00000467288	ENST00000418070	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
intron-intron	ENST00000467288	ENST00000418070	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
intron-intron	ENST00000467288	ENST00000418070	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
intron-intron	ENST00000467288	ENST00000418070	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
intron-intron	ENST00000467288	ENST00000426945	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
intron-intron	ENST00000467288	ENST00000426945	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
intron-intron	ENST00000467288	ENST00000426945	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
intron-intron	ENST00000467288	ENST00000426945	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
intron-intron	ENST00000467288	ENST00000426945	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
intron-intron	ENST00000467288	ENST00000428224	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
intron-intron	ENST00000467288	ENST00000428224	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
intron-intron	ENST00000467288	ENST00000428224	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
intron-intron	ENST00000467288	ENST00000428224	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
intron-intron	ENST00000467288	ENST00000428224	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
intron-intron	ENST00000467288	ENST00000430402	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
intron-intron	ENST00000467288	ENST00000430402	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
intron-intron	ENST00000467288	ENST00000430402	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
intron-intron	ENST00000467288	ENST00000430402	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
intron-intron	ENST00000467288	ENST00000430402	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
intron-intron	ENST00000467288	ENST00000437247	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
intron-intron	ENST00000467288	ENST00000437247	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
intron-intron	ENST00000467288	ENST00000437247	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
intron-intron	ENST00000467288	ENST00000437247	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
intron-intron	ENST00000467288	ENST00000437247	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
intron-intron	ENST00000467288	ENST00000440992	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
intron-intron	ENST00000467288	ENST00000440992	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
intron-intron	ENST00000467288	ENST00000440992	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
intron-intron	ENST00000467288	ENST00000440992	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
intron-intron	ENST00000467288	ENST00000440992	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
intron-intron	ENST00000467288	ENST00000451032	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
intron-intron	ENST00000467288	ENST00000451032	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
intron-intron	ENST00000467288	ENST00000451032	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
intron-intron	ENST00000467288	ENST00000451032	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
intron-intron	ENST00000467288	ENST00000451032	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
intron-intron	ENST00000467288	ENST00000454427	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
intron-intron	ENST00000467288	ENST00000454427	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
intron-intron	ENST00000467288	ENST00000454427	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
intron-intron	ENST00000467288	ENST00000454427	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
intron-intron	ENST00000467288	ENST00000454427	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
intron-intron	ENST00000467288	ENST00000468755	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
intron-intron	ENST00000467288	ENST00000468755	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
intron-intron	ENST00000467288	ENST00000468755	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
intron-intron	ENST00000467288	ENST00000468755	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
intron-intron	ENST00000467288	ENST00000468755	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
intron-intron	ENST00000467288	ENST00000469397	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
intron-intron	ENST00000467288	ENST00000469397	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
intron-intron	ENST00000467288	ENST00000469397	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
intron-intron	ENST00000467288	ENST00000469397	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
intron-intron	ENST00000467288	ENST00000469397	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
intron-intron	ENST00000467288	ENST00000472229	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
intron-intron	ENST00000467288	ENST00000472229	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
intron-intron	ENST00000467288	ENST00000472444	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
intron-intron	ENST00000467288	ENST00000472444	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
intron-intron	ENST00000467288	ENST00000472444	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
intron-intron	ENST00000467288	ENST00000472444	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
intron-intron	ENST00000467288	ENST00000477010	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
intron-intron	ENST00000467288	ENST00000477010	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
intron-intron	ENST00000467288	ENST00000477010	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
intron-intron	ENST00000467288	ENST00000477010	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
intron-intron	ENST00000467288	ENST00000477010	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
intron-intron	ENST00000467288	ENST00000489289	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
intron-intron	ENST00000467288	ENST00000489289	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
intron-intron	ENST00000467288	ENST00000489289	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
intron-intron	ENST00000467288	ENST00000489289	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
intron-intron	ENST00000467288	ENST00000493769	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
intron-intron	ENST00000467288	ENST00000493769	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+
intron-intron	ENST00000467288	ENST00000493769	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
intron-intron	ENST00000467288	ENST00000493769	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
intron-intron	ENST00000467288	ENST00000493769	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+
intron-intron	ENST00000467288	ENST00000506373	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+
intron-intron	ENST00000467288	ENST00000506373	GMDS	chr6	1726650	-	MRPS18B	chr6_dbb_hap3	1884247	+
intron-intron	ENST00000467288	ENST00000506373	GMDS	chr6	1726650	-	MRPS18B	chr6_ssto_hap7	1922888	+
intron-intron	ENST00000467288	ENST00000506373	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000530927	GMDS	chr6	1726650	-	ENST00000506373	MRPS18B	chr6	30592660	+	1785	945	48	956	302
ENST00000380815	GMDS	chr6	1726650	-	ENST00000506373	MRPS18B	chr6	30592660	+	2097	1257	42	1268	408
ENST00000530927	GMDS	chr6	1726649	-	ENST00000259873	MRPS18B	chr6	30590608	+	1966	945	48	1367	439
ENST00000380815	GMDS	chr6	1726649	-	ENST00000259873	MRPS18B	chr6	30590608	+	2278	1257	42	1679	545
ENST00000530927	GMDS	chr6	1726650	-	ENST00000259873	MRPS18B	chr6	30590609	+	1966	945	48	1367	439
ENST00000380815	GMDS	chr6	1726650	-	ENST00000259873	MRPS18B	chr6	30590609	+	2278	1257	42	1679	545

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000530927	ENST00000506373	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+	0.001187029	0.99881303
ENST00000380815	ENST00000506373	GMDS	chr6	1726650	-	MRPS18B	chr6	30592660	+	0.001515538	0.99848443
ENST00000530927	ENST00000259873	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+	0.000675199	0.9993248
ENST00000380815	ENST00000259873	GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+	0.001363277	0.99863666
ENST00000530927	ENST00000259873	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+	0.000675199	0.9993248
ENST00000380815	ENST00000259873	GMDS	chr6	1726650	-	MRPS18B	chr6	30590609	+	0.001363277	0.99863666

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Fusion Genomic Features for GMDS-MRPS18B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
GMDS	chr6	1726649	-	MRPS18B	chr6_ssto_hap7	1922887	+	0.006141665	0.9938584
GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+	0.001438155	0.9985619
GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+	0.001438155	0.9985619
GMDS	chr6	1726649	-	MRPS18B	chr6_dbb_hap3	1884246	+	0.000445918	0.9995541
GMDS	chr6	1726649	-	MRPS18B	chr6	30592659	+	3.74E-05	0.99996257
GMDS	chr6	1726649	-	MRPS18B	chr6_ssto_hap7	1922887	+	0.006141665	0.9938584
GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+	0.001438155	0.9985619
GMDS	chr6	1726649	-	MRPS18B	chr6	30590608	+	0.001438155	0.9985619
GMDS	chr6	1726649	-	MRPS18B	chr6_dbb_hap3	1884246	+	0.000445918	0.9995541
GMDS	chr6	1726649	-	MRPS18B	chr6	30592659	+	3.74E-05	0.99996257

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GMDS-MRPS18B

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:1726650/chr6:30592660)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	MRPS18B Q9Y676
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GMDS

chr6:1726649

chr6:30590608

ENST00000380815

108_112

329

373.0

Nucleotide binding

NADP

Hgene

GMDS

chr6:1726649

chr6:30590608

ENST00000380815

30_35

329

373.0

Nucleotide binding

NADP

Hgene

GMDS

chr6:1726649

chr6:30590608

ENST00000380815

55_58

329

373.0

Nucleotide binding

NADP

Hgene

GMDS

chr6:1726649

chr6:30590608

ENST00000380815

86_87

329

373.0

Nucleotide binding

NADP

Hgene

GMDS

chr6:1726649

chr6:30590608

ENST00000530927

108_112

299

343.0

Nucleotide binding

NADP

Hgene

GMDS

chr6:1726649

chr6:30590608

ENST00000530927

30_35

299

343.0

Nucleotide binding

NADP

Hgene

GMDS

chr6:1726649

chr6:30590608

ENST00000530927

55_58

299

343.0

Nucleotide binding

NADP

Hgene

GMDS

chr6:1726649

chr6:30590608

ENST00000530927

86_87

299

343.0

Nucleotide binding

NADP

Hgene

GMDS

chr6:1726650

chr6:30590609

ENST00000380815

108_112

329

373.0

Nucleotide binding

NADP

Hgene

GMDS

chr6:1726650

chr6:30590609

ENST00000380815

30_35

329

373.0

Nucleotide binding

NADP

Hgene

GMDS

chr6:1726650

chr6:30590609

ENST00000380815

55_58

329

373.0

Nucleotide binding

NADP

Hgene

GMDS

chr6:1726650

chr6:30590609

ENST00000380815

86_87

329

373.0

Nucleotide binding

NADP

Hgene

GMDS

chr6:1726650

chr6:30590609

ENST00000530927

108_112

299

343.0

Nucleotide binding

NADP

Hgene

GMDS

chr6:1726650

chr6:30590609

ENST00000530927

30_35

299

343.0

Nucleotide binding

NADP

Hgene

GMDS

chr6:1726650

chr6:30590609

ENST00000530927

55_58

299

343.0

Nucleotide binding

NADP

Hgene

GMDS

chr6:1726650

chr6:30590609

ENST00000530927

86_87

299

343.0

Nucleotide binding

NADP

Hgene

GMDS

chr6:1726650

chr6:30592660

ENST00000380815

108_112

329

373.0

Nucleotide binding

NADP

Hgene

GMDS

chr6:1726650

chr6:30592660

ENST00000380815

30_35

329

373.0

Nucleotide binding

NADP

Hgene

GMDS

chr6:1726650

chr6:30592660

ENST00000380815

55_58

329

373.0

Nucleotide binding

NADP

Hgene

GMDS

chr6:1726650

chr6:30592660

ENST00000380815

86_87

329

373.0

Nucleotide binding

NADP

Hgene

GMDS

chr6:1726650

chr6:30592660

ENST00000530927

108_112

299

343.0

Nucleotide binding

NADP

Hgene

GMDS

chr6:1726650

chr6:30592660

ENST00000530927

30_35

299

343.0

Nucleotide binding

NADP

Hgene

GMDS

chr6:1726650

chr6:30592660

ENST00000530927

55_58

299

343.0

Nucleotide binding

NADP

Hgene

GMDS

chr6:1726650

chr6:30592660

ENST00000530927

86_87

299

343.0

Nucleotide binding

NADP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for GMDS-MRPS18B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>33466_33466_1_GMDS-MRPS18B_GMDS_chr6_1726649_ENST00000380815_MRPS18B_chr6_30590608_ENST00000259873_length(transcript)=2278nt_BP=1257nt
GACGCGAATGACGCTGCGCCAGTCAGGCCGCAGCCCCGCTGCTTGGCCCGTCGGGCCCGCCTTGGCCGGCTCGGCCCGCCCCCGGCCCTC
CCTGCACGGCCTCCCGTGCGCCCCTGTCAGACTGTGGCGGCCGGTCGCGCGGTGCGCTCTCCCTCCCTGCCCGCAGCCTGGAGAGGCGCT
TCGTGCTGCACACCCCCGCGTTCCTGCCGGCACCGCGCCTGCCCTCTGCCGCGCTCCGCCCTGCCGCCGACCGCACGCCCGCCGCGGGAC
ATGGCACACGCACCGGCACGCTGCCCCAGCGCCCGGGGCTCCGGGGACGGCGAGATGGGCAAGCCCAGGAACGTGGCGCTCATCACCGGT
ATCACAGGCCAGGATGGTTCCTACCTGGCTGAGTTCCTGCTGGAGAAAGGCTATGAGGTCCATGGAATTGTACGGCGGTCCAGTTCATTT
AATACGGGTCGAATTGAGCATCTGTATAAGAATCCCCAGGCTCACATTGAAGGAAACATGAAGTTGCACTATGGCGATCTCACTGACAGT
ACCTGCCTTGTGAAGATCATTAATGAAGTAAAGCCCACAGAGATCTACAACCTTGGAGCCCAGAGCCACGTCAAAATTTCCTTTGACCTC
GCTGAGTACACTGCGGACGTTGACGGAGTTGGCACTCTACGACTTCTAGATGCAGTTAAGACTTGTGGCCTTATCAACTCTGTGAAGTTC
TACCAAGCCTCAACAAGTGAACTTTATGGGAAAGTGCAGGAAATACCCCAGAAGGAGACCACCCCTTTCTATCCCCGGTCACCCTATGGG
GCAGCAAAACTCTATGCCTATTGGATTGTGGTGAACTTCCGTGAGGCGTATAATCTCTTTGCAGTGAACGGCATTCTCTTCAATCATGAG
AGTCCCAGAAGAGGAGCTAATTTCGTTACTCGAAAAATTAGCCGGTCAGTAGCTAAGATTTACCTTGGACAACTGGAATGTTTCAGTTTG
GGAAATCTGGATGCCAAACGAGATTGGGGCCATGCCAAGGACTATGTGGAGGCTATGTGGTTGATGTTGCAGAATGATGAGCCGGAGGAC
TTCGTTATAGCTACTGGGGAGGTCCATAGTGTCCGGGAATTTGTCGAGAAATCATTCTTGCACATTGGAAAAACCATTGTGTGGGAAGGA
AAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACCGGCAAAGTTCACGTGACTGTGGATCTCAAGTACTACCGGCCAACTGAAGTGAAC
GTGAAGCTCTTGGAGCAATTTGTCTGCGCCCACACGGGTATCATCTTCTATGCTCCATACACAGGAGTCTGTGTGAAGCAGCACAAGCGG
TTGACCCAGGCCATCCAGAAAGCCAGGGATCATGGTCTCCTCATTTACCACATCCCCCAGGTTGAACCACGGGACCTTGACTTCAGTACC
TCTCATGGGGCTGTGAGTGCTACTCCGCCAGCCCCCACCCTGGTCTCAGGTGACCCCTGGTACCCATGGTACAACTGGAAACAGCCACCG
GAGAGAGAACTGTCTCGCCTTCGCCGGCTTTACCAGGGTCATCTCCAAGAAGAGAGTGGCCCCCCACCTGAGTCAATGCCCAAGATGCCC
CCTAGAACACCAGCGGAAGCCTCCTCCACTGGGCAGACAGGCCCTCAGAGTGCTCTGTAGGAGCTGTAGACTGGGAAGAGAGGCCAGGCG
TGGTGGCTCACTCCTGTAATCCCAGCACTTTGGGAAGCCAAGGTGGGCTGATCACTTGATCCCAGGAGTTTGAGACCAGCCTGGGCACCA
TGGTGAAACCTCGTCTTTACCAAAAAATACAAAAATTAGCTGGGTGTGGTGGTGCACACCTGTAGTCTCAACTATTGGGGAGGCTAAGGT
AGGATCACTTGATCCCAGGAGGCGGAGGTTGCAGTGAGTTGCAGTCACACCCCTGCACTCCAGCCTGGGTGACAGCTAGACCCTGTCTCA
AAAAAAAAAAAAAAGACTGGGAAGAGAGCTAGAGGGACTAGGAGATAATGTGTATGTAGGTTTATGTGATGGGATATCACCCTGAAGAGT
TGTGTCTTTTGTGGCCAGTGACAAATCCAGGAAATGAATGTTGCTGATAGGGATAAATCTTGAGGCTGAGGGCGGGTGGTACAGATGTGT
ATGGGAAACCCCAACCCCTATATATTGTAAATAGATGGGCTGGGCTAAACATTGTTGCCGTTTCATACTTCTACCAACTCAGCTTTTACA

>33466_33466_1_GMDS-MRPS18B_GMDS_chr6_1726649_ENST00000380815_MRPS18B_chr6_30590608_ENST00000259873_length(amino acids)=545AA_BP=405
MARRARLGRLGPPPALPARPPVRPCQTVAAGRAVRSPSLPAAWRGASCCTPPRSCRHRACPLPRSALPPTARPPRDMAHAPARCPSARGS
GDGEMGKPRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTE
IYNLGAQSHVKISFDLAEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFR
EAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSLGNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREF
VEKSFLHIGKTIVWEGKNENEVGRCKETGKVHVTVDLKYYRPTEVNVKLLEQFVCAHTGIIFYAPYTGVCVKQHKRLTQAIQKARDHGLL
IYHIPQVEPRDLDFSTSHGAVSATPPAPTLVSGDPWYPWYNWKQPPERELSRLRRLYQGHLQEESGPPPESMPKMPPRTPAEASSTGQTG

--------------------------------------------------------------
>33466_33466_2_GMDS-MRPS18B_GMDS_chr6_1726649_ENST00000530927_MRPS18B_chr6_30590608_ENST00000259873_length(transcript)=1966nt_BP=945nt
TGTACACAGGCAGTTTGTTGGGAGCGTTACCATTGCCTCTGGTTCCTCATGTGTAAAATGGATGGTTCCTACCTGGCTGAGTTCCTGCTG
GAGAAAGGCTATGAGGTCCATGGAATTGTACGGCGGTCCAGTTCATTTAATACGGGTCGAATTGAGCATCTGTATAAGAATCCCCAGGCT
CACATTGAAGGAAACATGAAGTTGCACTATGGCGATCTCACTGACAGTACCTGCCTTGTGAAGATCATTAATGAAGTAAAGCCCACAGAG
ATCTACAACCTTGGAGCCCAGAGCCACGTCAAAATTTCCTTTGACCTCGCTGAGTACACTGCGGACGTTGACGGAGTTGGCACTCTACGA
CTTCTAGATGCAGTTAAGACTTGTGGCCTTATCAACTCTGTGAAGTTCTACCAAGCCTCAACAAGTGAACTTTATGGGAAAGTGCAGGAA
ATACCCCAGAAGGAGACCACCCCTTTCTATCCCCGGTCACCCTATGGGGCAGCAAAACTCTATGCCTATTGGATTGTGGTGAACTTCCGT
GAGGCGTATAATCTCTTTGCAGTGAACGGCATTCTCTTCAATCATGAGAGTCCCAGAAGAGGAGCTAATTTCGTTACTCGAAAAATTAGC
CGGTCAGTAGCTAAGATTTACCTTGGACAACTGGAATGTTTCAGTTTGGGAAATCTGGATGCCAAACGAGATTGGGGCCATGCCAAGGAC
TATGTGGAGGCTATGTGGTTGATGTTGCAGAATGATGAGCCGGAGGACTTCGTTATAGCTACTGGGGAGGTCCATAGTGTCCGGGAATTT
GTCGAGAAATCATTCTTGCACATTGGAAAAACCATTGTGTGGGAAGGAAAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACCGGCAAA
GTTCACGTGACTGTGGATCTCAAGTACTACCGGCCAACTGAAGTGAACGTGAAGCTCTTGGAGCAATTTGTCTGCGCCCACACGGGTATC
ATCTTCTATGCTCCATACACAGGAGTCTGTGTGAAGCAGCACAAGCGGTTGACCCAGGCCATCCAGAAAGCCAGGGATCATGGTCTCCTC
ATTTACCACATCCCCCAGGTTGAACCACGGGACCTTGACTTCAGTACCTCTCATGGGGCTGTGAGTGCTACTCCGCCAGCCCCCACCCTG
GTCTCAGGTGACCCCTGGTACCCATGGTACAACTGGAAACAGCCACCGGAGAGAGAACTGTCTCGCCTTCGCCGGCTTTACCAGGGTCAT
CTCCAAGAAGAGAGTGGCCCCCCACCTGAGTCAATGCCCAAGATGCCCCCTAGAACACCAGCGGAAGCCTCCTCCACTGGGCAGACAGGC
CCTCAGAGTGCTCTGTAGGAGCTGTAGACTGGGAAGAGAGGCCAGGCGTGGTGGCTCACTCCTGTAATCCCAGCACTTTGGGAAGCCAAG
GTGGGCTGATCACTTGATCCCAGGAGTTTGAGACCAGCCTGGGCACCATGGTGAAACCTCGTCTTTACCAAAAAATACAAAAATTAGCTG
GGTGTGGTGGTGCACACCTGTAGTCTCAACTATTGGGGAGGCTAAGGTAGGATCACTTGATCCCAGGAGGCGGAGGTTGCAGTGAGTTGC
AGTCACACCCCTGCACTCCAGCCTGGGTGACAGCTAGACCCTGTCTCAAAAAAAAAAAAAAAGACTGGGAAGAGAGCTAGAGGGACTAGG
AGATAATGTGTATGTAGGTTTATGTGATGGGATATCACCCTGAAGAGTTGTGTCTTTTGTGGCCAGTGACAAATCCAGGAAATGAATGTT
GCTGATAGGGATAAATCTTGAGGCTGAGGGCGGGTGGTACAGATGTGTATGGGAAACCCCAACCCCTATATATTGTAAATAGATGGGCTG

>33466_33466_2_GMDS-MRPS18B_GMDS_chr6_1726649_ENST00000530927_MRPS18B_chr6_30590608_ENST00000259873_length(amino acids)=439AA_BP=299
MCKMDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDL
AEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREAYNLFAVNGILFNHE
SPRRGANFVTRKISRSVAKIYLGQLECFSLGNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEG
KNENEVGRCKETGKVHVTVDLKYYRPTEVNVKLLEQFVCAHTGIIFYAPYTGVCVKQHKRLTQAIQKARDHGLLIYHIPQVEPRDLDFST

--------------------------------------------------------------
>33466_33466_3_GMDS-MRPS18B_GMDS_chr6_1726650_ENST00000380815_MRPS18B_chr6_30590609_ENST00000259873_length(transcript)=2278nt_BP=1257nt
GACGCGAATGACGCTGCGCCAGTCAGGCCGCAGCCCCGCTGCTTGGCCCGTCGGGCCCGCCTTGGCCGGCTCGGCCCGCCCCCGGCCCTC
CCTGCACGGCCTCCCGTGCGCCCCTGTCAGACTGTGGCGGCCGGTCGCGCGGTGCGCTCTCCCTCCCTGCCCGCAGCCTGGAGAGGCGCT
TCGTGCTGCACACCCCCGCGTTCCTGCCGGCACCGCGCCTGCCCTCTGCCGCGCTCCGCCCTGCCGCCGACCGCACGCCCGCCGCGGGAC
ATGGCACACGCACCGGCACGCTGCCCCAGCGCCCGGGGCTCCGGGGACGGCGAGATGGGCAAGCCCAGGAACGTGGCGCTCATCACCGGT
ATCACAGGCCAGGATGGTTCCTACCTGGCTGAGTTCCTGCTGGAGAAAGGCTATGAGGTCCATGGAATTGTACGGCGGTCCAGTTCATTT
AATACGGGTCGAATTGAGCATCTGTATAAGAATCCCCAGGCTCACATTGAAGGAAACATGAAGTTGCACTATGGCGATCTCACTGACAGT
ACCTGCCTTGTGAAGATCATTAATGAAGTAAAGCCCACAGAGATCTACAACCTTGGAGCCCAGAGCCACGTCAAAATTTCCTTTGACCTC
GCTGAGTACACTGCGGACGTTGACGGAGTTGGCACTCTACGACTTCTAGATGCAGTTAAGACTTGTGGCCTTATCAACTCTGTGAAGTTC
TACCAAGCCTCAACAAGTGAACTTTATGGGAAAGTGCAGGAAATACCCCAGAAGGAGACCACCCCTTTCTATCCCCGGTCACCCTATGGG
GCAGCAAAACTCTATGCCTATTGGATTGTGGTGAACTTCCGTGAGGCGTATAATCTCTTTGCAGTGAACGGCATTCTCTTCAATCATGAG
AGTCCCAGAAGAGGAGCTAATTTCGTTACTCGAAAAATTAGCCGGTCAGTAGCTAAGATTTACCTTGGACAACTGGAATGTTTCAGTTTG
GGAAATCTGGATGCCAAACGAGATTGGGGCCATGCCAAGGACTATGTGGAGGCTATGTGGTTGATGTTGCAGAATGATGAGCCGGAGGAC
TTCGTTATAGCTACTGGGGAGGTCCATAGTGTCCGGGAATTTGTCGAGAAATCATTCTTGCACATTGGAAAAACCATTGTGTGGGAAGGA
AAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACCGGCAAAGTTCACGTGACTGTGGATCTCAAGTACTACCGGCCAACTGAAGTGAAC
GTGAAGCTCTTGGAGCAATTTGTCTGCGCCCACACGGGTATCATCTTCTATGCTCCATACACAGGAGTCTGTGTGAAGCAGCACAAGCGG
TTGACCCAGGCCATCCAGAAAGCCAGGGATCATGGTCTCCTCATTTACCACATCCCCCAGGTTGAACCACGGGACCTTGACTTCAGTACC
TCTCATGGGGCTGTGAGTGCTACTCCGCCAGCCCCCACCCTGGTCTCAGGTGACCCCTGGTACCCATGGTACAACTGGAAACAGCCACCG
GAGAGAGAACTGTCTCGCCTTCGCCGGCTTTACCAGGGTCATCTCCAAGAAGAGAGTGGCCCCCCACCTGAGTCAATGCCCAAGATGCCC
CCTAGAACACCAGCGGAAGCCTCCTCCACTGGGCAGACAGGCCCTCAGAGTGCTCTGTAGGAGCTGTAGACTGGGAAGAGAGGCCAGGCG
TGGTGGCTCACTCCTGTAATCCCAGCACTTTGGGAAGCCAAGGTGGGCTGATCACTTGATCCCAGGAGTTTGAGACCAGCCTGGGCACCA
TGGTGAAACCTCGTCTTTACCAAAAAATACAAAAATTAGCTGGGTGTGGTGGTGCACACCTGTAGTCTCAACTATTGGGGAGGCTAAGGT
AGGATCACTTGATCCCAGGAGGCGGAGGTTGCAGTGAGTTGCAGTCACACCCCTGCACTCCAGCCTGGGTGACAGCTAGACCCTGTCTCA
AAAAAAAAAAAAAAGACTGGGAAGAGAGCTAGAGGGACTAGGAGATAATGTGTATGTAGGTTTATGTGATGGGATATCACCCTGAAGAGT
TGTGTCTTTTGTGGCCAGTGACAAATCCAGGAAATGAATGTTGCTGATAGGGATAAATCTTGAGGCTGAGGGCGGGTGGTACAGATGTGT
ATGGGAAACCCCAACCCCTATATATTGTAAATAGATGGGCTGGGCTAAACATTGTTGCCGTTTCATACTTCTACCAACTCAGCTTTTACA

>33466_33466_3_GMDS-MRPS18B_GMDS_chr6_1726650_ENST00000380815_MRPS18B_chr6_30590609_ENST00000259873_length(amino acids)=545AA_BP=405
MARRARLGRLGPPPALPARPPVRPCQTVAAGRAVRSPSLPAAWRGASCCTPPRSCRHRACPLPRSALPPTARPPRDMAHAPARCPSARGS
GDGEMGKPRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTE
IYNLGAQSHVKISFDLAEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFR
EAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSLGNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREF
VEKSFLHIGKTIVWEGKNENEVGRCKETGKVHVTVDLKYYRPTEVNVKLLEQFVCAHTGIIFYAPYTGVCVKQHKRLTQAIQKARDHGLL
IYHIPQVEPRDLDFSTSHGAVSATPPAPTLVSGDPWYPWYNWKQPPERELSRLRRLYQGHLQEESGPPPESMPKMPPRTPAEASSTGQTG

--------------------------------------------------------------
>33466_33466_4_GMDS-MRPS18B_GMDS_chr6_1726650_ENST00000380815_MRPS18B_chr6_30592660_ENST00000506373_length(transcript)=2097nt_BP=1257nt
GACGCGAATGACGCTGCGCCAGTCAGGCCGCAGCCCCGCTGCTTGGCCCGTCGGGCCCGCCTTGGCCGGCTCGGCCCGCCCCCGGCCCTC
CCTGCACGGCCTCCCGTGCGCCCCTGTCAGACTGTGGCGGCCGGTCGCGCGGTGCGCTCTCCCTCCCTGCCCGCAGCCTGGAGAGGCGCT
TCGTGCTGCACACCCCCGCGTTCCTGCCGGCACCGCGCCTGCCCTCTGCCGCGCTCCGCCCTGCCGCCGACCGCACGCCCGCCGCGGGAC
ATGGCACACGCACCGGCACGCTGCCCCAGCGCCCGGGGCTCCGGGGACGGCGAGATGGGCAAGCCCAGGAACGTGGCGCTCATCACCGGT
ATCACAGGCCAGGATGGTTCCTACCTGGCTGAGTTCCTGCTGGAGAAAGGCTATGAGGTCCATGGAATTGTACGGCGGTCCAGTTCATTT
AATACGGGTCGAATTGAGCATCTGTATAAGAATCCCCAGGCTCACATTGAAGGAAACATGAAGTTGCACTATGGCGATCTCACTGACAGT
ACCTGCCTTGTGAAGATCATTAATGAAGTAAAGCCCACAGAGATCTACAACCTTGGAGCCCAGAGCCACGTCAAAATTTCCTTTGACCTC
GCTGAGTACACTGCGGACGTTGACGGAGTTGGCACTCTACGACTTCTAGATGCAGTTAAGACTTGTGGCCTTATCAACTCTGTGAAGTTC
TACCAAGCCTCAACAAGTGAACTTTATGGGAAAGTGCAGGAAATACCCCAGAAGGAGACCACCCCTTTCTATCCCCGGTCACCCTATGGG
GCAGCAAAACTCTATGCCTATTGGATTGTGGTGAACTTCCGTGAGGCGTATAATCTCTTTGCAGTGAACGGCATTCTCTTCAATCATGAG
AGTCCCAGAAGAGGAGCTAATTTCGTTACTCGAAAAATTAGCCGGTCAGTAGCTAAGATTTACCTTGGACAACTGGAATGTTTCAGTTTG
GGAAATCTGGATGCCAAACGAGATTGGGGCCATGCCAAGGACTATGTGGAGGCTATGTGGTTGATGTTGCAGAATGATGAGCCGGAGGAC
TTCGTTATAGCTACTGGGGAGGTCCATAGTGTCCGGGAATTTGTCGAGAAATCATTCTTGCACATTGGAAAAACCATTGTGTGGGAAGGA
AAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACCGGCAAAGTTCACGTGACTGTGGATCTCAAGTACTACCGGCCAACTGAAGTGGAG
TCTGTGTGAAGCAGCACAAGCGGTTGACCCAGGCCATCCAGAAAGCCAGGGATCATGGTCTCCTCATTTACCACATCCCCCAGGTTGAAC
CACGGGACCTTGACTTCAGTACCTCTCATGGGGCTGTGAGTGCTACTCCGCCAGCCCCCACCCTGGTCTCAGGTGACCCCTGGTACCCAT
GGTACAACTGGAAACAGCCACCGGAGAGAGAACTGTCTCGCCTTCGCCGGCTTTACCAGGGTCATCTCCAAGAAGAGAGTGGCCCCCCAC
CTGAGTCAATGCCCAAGATGCCCCCTAGAACACCAGCGGAAGCCTCCTCCACTGGGCAGACAGGCCCTCAGAGTGCTCTGTAGGAGCTGT
AGACTGGGAAGAGAGGCCAGGCGTGGTGGCTCACTCCTGTAATCCCAGCACTTTGGGAAGCCAAGGTGGGCTGATCACTTGATCCCAGGA
GTTTGAGACCAGCCTGGGCACCATGGTGAAACCTCGTCTTTACCAAAAAATACAAAAATTAGCTGGGTGTGGTGGTGCACACCTGTAGTC
TCAACTATTGGGGAGGCTAAGGTAGGATCACTTGATCCCAGGAGGCGGAGGTTGCAGTGAGTTGCAGTCACACCCCTGCACTCCAGCCTG
GGTGACAGCTAGACCCTGTCTCAAAAAAAAAAAAAAAGACTGGGAAGAGAGCTAGAGGGACTAGGAGATAATGTGTATGTAGGTTTATGT
GATGGGATATCACCCTGAAGAGTTGTGTCTTTTGTGGCCAGTGACAAATCCAGGAAATGAATGTTGCTGATAGGGATAAATCTTGAGGCT

>33466_33466_4_GMDS-MRPS18B_GMDS_chr6_1726650_ENST00000380815_MRPS18B_chr6_30592660_ENST00000506373_length(amino acids)=408AA_BP=
MARRARLGRLGPPPALPARPPVRPCQTVAAGRAVRSPSLPAAWRGASCCTPPRSCRHRACPLPRSALPPTARPPRDMAHAPARCPSARGS
GDGEMGKPRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTE
IYNLGAQSHVKISFDLAEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFR
EAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSLGNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREF

--------------------------------------------------------------
>33466_33466_5_GMDS-MRPS18B_GMDS_chr6_1726650_ENST00000530927_MRPS18B_chr6_30590609_ENST00000259873_length(transcript)=1966nt_BP=945nt
TGTACACAGGCAGTTTGTTGGGAGCGTTACCATTGCCTCTGGTTCCTCATGTGTAAAATGGATGGTTCCTACCTGGCTGAGTTCCTGCTG
GAGAAAGGCTATGAGGTCCATGGAATTGTACGGCGGTCCAGTTCATTTAATACGGGTCGAATTGAGCATCTGTATAAGAATCCCCAGGCT
CACATTGAAGGAAACATGAAGTTGCACTATGGCGATCTCACTGACAGTACCTGCCTTGTGAAGATCATTAATGAAGTAAAGCCCACAGAG
ATCTACAACCTTGGAGCCCAGAGCCACGTCAAAATTTCCTTTGACCTCGCTGAGTACACTGCGGACGTTGACGGAGTTGGCACTCTACGA
CTTCTAGATGCAGTTAAGACTTGTGGCCTTATCAACTCTGTGAAGTTCTACCAAGCCTCAACAAGTGAACTTTATGGGAAAGTGCAGGAA
ATACCCCAGAAGGAGACCACCCCTTTCTATCCCCGGTCACCCTATGGGGCAGCAAAACTCTATGCCTATTGGATTGTGGTGAACTTCCGT
GAGGCGTATAATCTCTTTGCAGTGAACGGCATTCTCTTCAATCATGAGAGTCCCAGAAGAGGAGCTAATTTCGTTACTCGAAAAATTAGC
CGGTCAGTAGCTAAGATTTACCTTGGACAACTGGAATGTTTCAGTTTGGGAAATCTGGATGCCAAACGAGATTGGGGCCATGCCAAGGAC
TATGTGGAGGCTATGTGGTTGATGTTGCAGAATGATGAGCCGGAGGACTTCGTTATAGCTACTGGGGAGGTCCATAGTGTCCGGGAATTT
GTCGAGAAATCATTCTTGCACATTGGAAAAACCATTGTGTGGGAAGGAAAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACCGGCAAA
GTTCACGTGACTGTGGATCTCAAGTACTACCGGCCAACTGAAGTGAACGTGAAGCTCTTGGAGCAATTTGTCTGCGCCCACACGGGTATC
ATCTTCTATGCTCCATACACAGGAGTCTGTGTGAAGCAGCACAAGCGGTTGACCCAGGCCATCCAGAAAGCCAGGGATCATGGTCTCCTC
ATTTACCACATCCCCCAGGTTGAACCACGGGACCTTGACTTCAGTACCTCTCATGGGGCTGTGAGTGCTACTCCGCCAGCCCCCACCCTG
GTCTCAGGTGACCCCTGGTACCCATGGTACAACTGGAAACAGCCACCGGAGAGAGAACTGTCTCGCCTTCGCCGGCTTTACCAGGGTCAT
CTCCAAGAAGAGAGTGGCCCCCCACCTGAGTCAATGCCCAAGATGCCCCCTAGAACACCAGCGGAAGCCTCCTCCACTGGGCAGACAGGC
CCTCAGAGTGCTCTGTAGGAGCTGTAGACTGGGAAGAGAGGCCAGGCGTGGTGGCTCACTCCTGTAATCCCAGCACTTTGGGAAGCCAAG
GTGGGCTGATCACTTGATCCCAGGAGTTTGAGACCAGCCTGGGCACCATGGTGAAACCTCGTCTTTACCAAAAAATACAAAAATTAGCTG
GGTGTGGTGGTGCACACCTGTAGTCTCAACTATTGGGGAGGCTAAGGTAGGATCACTTGATCCCAGGAGGCGGAGGTTGCAGTGAGTTGC
AGTCACACCCCTGCACTCCAGCCTGGGTGACAGCTAGACCCTGTCTCAAAAAAAAAAAAAAAGACTGGGAAGAGAGCTAGAGGGACTAGG
AGATAATGTGTATGTAGGTTTATGTGATGGGATATCACCCTGAAGAGTTGTGTCTTTTGTGGCCAGTGACAAATCCAGGAAATGAATGTT
GCTGATAGGGATAAATCTTGAGGCTGAGGGCGGGTGGTACAGATGTGTATGGGAAACCCCAACCCCTATATATTGTAAATAGATGGGCTG

>33466_33466_5_GMDS-MRPS18B_GMDS_chr6_1726650_ENST00000530927_MRPS18B_chr6_30590609_ENST00000259873_length(amino acids)=439AA_BP=299
MCKMDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDL
AEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREAYNLFAVNGILFNHE
SPRRGANFVTRKISRSVAKIYLGQLECFSLGNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEG
KNENEVGRCKETGKVHVTVDLKYYRPTEVNVKLLEQFVCAHTGIIFYAPYTGVCVKQHKRLTQAIQKARDHGLLIYHIPQVEPRDLDFST

--------------------------------------------------------------
>33466_33466_6_GMDS-MRPS18B_GMDS_chr6_1726650_ENST00000530927_MRPS18B_chr6_30592660_ENST00000506373_length(transcript)=1785nt_BP=945nt
TGTACACAGGCAGTTTGTTGGGAGCGTTACCATTGCCTCTGGTTCCTCATGTGTAAAATGGATGGTTCCTACCTGGCTGAGTTCCTGCTG
GAGAAAGGCTATGAGGTCCATGGAATTGTACGGCGGTCCAGTTCATTTAATACGGGTCGAATTGAGCATCTGTATAAGAATCCCCAGGCT
CACATTGAAGGAAACATGAAGTTGCACTATGGCGATCTCACTGACAGTACCTGCCTTGTGAAGATCATTAATGAAGTAAAGCCCACAGAG
ATCTACAACCTTGGAGCCCAGAGCCACGTCAAAATTTCCTTTGACCTCGCTGAGTACACTGCGGACGTTGACGGAGTTGGCACTCTACGA
CTTCTAGATGCAGTTAAGACTTGTGGCCTTATCAACTCTGTGAAGTTCTACCAAGCCTCAACAAGTGAACTTTATGGGAAAGTGCAGGAA
ATACCCCAGAAGGAGACCACCCCTTTCTATCCCCGGTCACCCTATGGGGCAGCAAAACTCTATGCCTATTGGATTGTGGTGAACTTCCGT
GAGGCGTATAATCTCTTTGCAGTGAACGGCATTCTCTTCAATCATGAGAGTCCCAGAAGAGGAGCTAATTTCGTTACTCGAAAAATTAGC
CGGTCAGTAGCTAAGATTTACCTTGGACAACTGGAATGTTTCAGTTTGGGAAATCTGGATGCCAAACGAGATTGGGGCCATGCCAAGGAC
TATGTGGAGGCTATGTGGTTGATGTTGCAGAATGATGAGCCGGAGGACTTCGTTATAGCTACTGGGGAGGTCCATAGTGTCCGGGAATTT
GTCGAGAAATCATTCTTGCACATTGGAAAAACCATTGTGTGGGAAGGAAAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACCGGCAAA
GTTCACGTGACTGTGGATCTCAAGTACTACCGGCCAACTGAAGTGGAGTCTGTGTGAAGCAGCACAAGCGGTTGACCCAGGCCATCCAGA
AAGCCAGGGATCATGGTCTCCTCATTTACCACATCCCCCAGGTTGAACCACGGGACCTTGACTTCAGTACCTCTCATGGGGCTGTGAGTG
CTACTCCGCCAGCCCCCACCCTGGTCTCAGGTGACCCCTGGTACCCATGGTACAACTGGAAACAGCCACCGGAGAGAGAACTGTCTCGCC
TTCGCCGGCTTTACCAGGGTCATCTCCAAGAAGAGAGTGGCCCCCCACCTGAGTCAATGCCCAAGATGCCCCCTAGAACACCAGCGGAAG
CCTCCTCCACTGGGCAGACAGGCCCTCAGAGTGCTCTGTAGGAGCTGTAGACTGGGAAGAGAGGCCAGGCGTGGTGGCTCACTCCTGTAA
TCCCAGCACTTTGGGAAGCCAAGGTGGGCTGATCACTTGATCCCAGGAGTTTGAGACCAGCCTGGGCACCATGGTGAAACCTCGTCTTTA
CCAAAAAATACAAAAATTAGCTGGGTGTGGTGGTGCACACCTGTAGTCTCAACTATTGGGGAGGCTAAGGTAGGATCACTTGATCCCAGG
AGGCGGAGGTTGCAGTGAGTTGCAGTCACACCCCTGCACTCCAGCCTGGGTGACAGCTAGACCCTGTCTCAAAAAAAAAAAAAAAGACTG
GGAAGAGAGCTAGAGGGACTAGGAGATAATGTGTATGTAGGTTTATGTGATGGGATATCACCCTGAAGAGTTGTGTCTTTTGTGGCCAGT

>33466_33466_6_GMDS-MRPS18B_GMDS_chr6_1726650_ENST00000530927_MRPS18B_chr6_30592660_ENST00000506373_length(amino acids)=302AA_BP=
MCKMDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDL
AEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREAYNLFAVNGILFNHE
SPRRGANFVTRKISRSVAKIYLGQLECFSLGNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for GMDS-MRPS18B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GMDS-MRPS18B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for GMDS-MRPS18B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source