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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GMDS-PPP1R11 (FusionGDB2 ID:33470)

Fusion Gene Summary for GMDS-PPP1R11

Fusion gene summary

Fusion gene information	Fusion gene name: GMDS-PPP1R11
	Fusion gene ID: 33470
		Hgene	Tgene
	Gene symbol	GMDS	PPP1R11
	Gene ID	2762	6992
	Gene name	GDP-mannose 4,6-dehydratase	protein phosphatase 1 regulatory inhibitor subunit 11
	Synonyms	GMD\|SDR3E1	CFAP255\|HCG-V\|HCGV\|IPP3\|TCTE5\|TCTEX5
	Cytomap	6p25.3	6p22.1
	Type of gene	protein-coding	protein-coding
	Description	GDP-mannose 4,6 dehydrataseGDP-D-mannose dehydrataseshort chain dehydrogenase/reductase family 3E, member 1	E3 ubiquitin-protein ligase PPP1R11HCG Vhemochromatosis candidate gene V proteininhibitor-3protein phosphatase 1 regulatory subunit 11protein phosphatase 1, regulatory (inhibitor) subunit 11protein phosphatase inhibitor 3t-complex-associated-testis
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000380815, ENST00000530927, ENST00000467288,	ENST00000376758, ENST00000376763, ENST00000376765, ENST00000376769, ENST00000376772, ENST00000376773, ENST00000383612, ENST00000400654, ENST00000400655, ENST00000400656, ENST00000400657, ENST00000400658, ENST00000412077, ENST00000414032, ENST00000414618, ENST00000417223, ENST00000418211, ENST00000422273, ENST00000428563, ENST00000429382, ENST00000430828, ENST00000430959, ENST00000431424, ENST00000431977, ENST00000433662, ENST00000433942, ENST00000434591, ENST00000436591, ENST00000436833, ENST00000437171, ENST00000437937, ENST00000439463, ENST00000441553, ENST00000444101, ENST00000444994, ENST00000446310, ENST00000448210, ENST00000448378, ENST00000448550, ENST00000449087, ENST00000449435, ENST00000450177, ENST00000451993, ENST00000452227, ENST00000452679, ENST00000455350, ENST00000455887, ENST00000458506,
Fusion gene scores	* DoF score	28 X 19 X 15=7980	5 X 5 X 2=50
	# samples	32	6
	** MAII score	log2(32/7980*10)=-4.64024493622235 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/50*10)=0.263034405833794 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: GMDS [Title/Abstract] AND PPP1R11 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GMDS(1930337)-PPP1R11(30036367), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GMDS	GO:0019673	GDP-mannose metabolic process	9525924
Hgene	GMDS	GO:0042351	'de novo' GDP-L-fucose biosynthetic process	9525924

Fusion gene breakpoints across GMDS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PPP1R11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	DLBC	TCGA-VB-A8QN-01A	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
ChimerDB4	DLBC	TCGA-VB-A8QN	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+

Top

Fusion Gene ORF analysis for GMDS-PPP1R11

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000380815	ENST00000376758	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-5UTR	ENST00000380815	ENST00000376763	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-5UTR	ENST00000380815	ENST00000376765	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-5UTR	ENST00000380815	ENST00000376769	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-5UTR	ENST00000380815	ENST00000376772	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-5UTR	ENST00000380815	ENST00000376773	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-5UTR	ENST00000530927	ENST00000376758	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-5UTR	ENST00000530927	ENST00000376763	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-5UTR	ENST00000530927	ENST00000376765	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-5UTR	ENST00000530927	ENST00000376769	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-5UTR	ENST00000530927	ENST00000376772	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-5UTR	ENST00000530927	ENST00000376773	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000383612	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000400654	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000400655	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000400656	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000400657	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000400658	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000412077	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000414032	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000414618	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000417223	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000418211	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000422273	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000428563	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000429382	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000430828	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000430959	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000431424	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000431977	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000433662	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000433942	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000434591	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000436591	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000436833	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000437171	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000437937	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000439463	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000441553	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000444101	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000444994	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000446310	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000448210	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000448378	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000448550	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000449087	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000449435	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000450177	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000451993	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000452227	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000452679	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000455350	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000455887	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000380815	ENST00000458506	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000383612	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000400654	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000400655	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000400656	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000400657	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000400658	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000412077	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000414032	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000414618	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000417223	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000418211	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000422273	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000428563	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000429382	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000430828	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000430959	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000431424	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000431977	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000433662	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000433942	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000434591	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000436591	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000436833	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000437171	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000437937	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000439463	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000441553	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000444101	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000444994	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000446310	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000448210	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000448378	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000448550	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000449087	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000449435	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000450177	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000451993	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000452227	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000452679	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000455350	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000455887	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
5CDS-intron	ENST00000530927	ENST00000458506	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-5UTR	ENST00000467288	ENST00000376758	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-5UTR	ENST00000467288	ENST00000376763	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-5UTR	ENST00000467288	ENST00000376765	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-5UTR	ENST00000467288	ENST00000376769	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-5UTR	ENST00000467288	ENST00000376772	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-5UTR	ENST00000467288	ENST00000376773	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000383612	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000400654	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000400655	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000400656	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000400657	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000400658	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000412077	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000414032	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000414618	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000417223	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000418211	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000422273	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000428563	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000429382	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000430828	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000430959	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000431424	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000431977	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000433662	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000433942	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000434591	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000436591	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000436833	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000437171	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000437937	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000439463	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000441553	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000444101	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000444994	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000446310	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000448210	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000448378	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000448550	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000449087	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000449435	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000450177	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000451993	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000452227	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000452679	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000455350	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000455887	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+
intron-intron	ENST00000467288	ENST00000458506	GMDS	chr6	1930337	-	PPP1R11	chr6	30036367	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for GMDS-PPP1R11

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
GMDS	chr6	1930336	-	PPP1R11	chr6	30036366	+	5.71E-05	0.9999429
GMDS	chr6	1930336	-	PPP1R11	chr6	30036366	+	5.71E-05	0.9999429
GMDS	chr6	1930336	-	PPP1R11	chr6	30036366	+	5.71E-05	0.9999429
GMDS	chr6	1930336	-	PPP1R11	chr6	30036366	+	5.71E-05	0.9999429

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GMDS-PPP1R11

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:1930337/:30036367)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for GMDS-PPP1R11

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GMDS-PPP1R11

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for GMDS-PPP1R11

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for GMDS-PPP1R11

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source