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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GMDS-VAPB (FusionGDB2 ID:33475)

Fusion Gene Summary for GMDS-VAPB

check button Fusion gene summary
Fusion gene informationFusion gene name: GMDS-VAPB
Fusion gene ID: 33475
HgeneTgene
Gene symbol

GMDS

VAPB

Gene ID

2762

9217

Gene nameGDP-mannose 4,6-dehydrataseVAMP associated protein B and C
SynonymsGMD|SDR3E1ALS8|VAMP-B|VAP-B
Cytomap

6p25.3

20q13.32

Type of geneprotein-codingprotein-coding
DescriptionGDP-mannose 4,6 dehydrataseGDP-D-mannose dehydrataseshort chain dehydrogenase/reductase family 3E, member 1vesicle-associated membrane protein-associated protein B/CVAMP (vesicle-associated membrane protein)-associated protein B and CVAMP-associated 33 kDa protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000380815, ENST00000530927, 
ENST00000467288, 		ENST00000265619, 
ENST00000395802, ENST00000475243, 
Fusion gene scores* DoF score28 X 19 X 15=798011 X 11 X 6=726
# samples 3212
** MAII scorelog2(32/7980*10)=-4.64024493622235
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/726*10)=-2.59693514238723
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GMDS [Title/Abstract] AND VAPB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGMDS(1930337)-VAPB(57019133), # samples:3
Anticipated loss of major functional domain due to fusion event.GMDS-VAPB seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
GMDS-VAPB seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
GMDS-VAPB seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGMDS

GO:0019673

GDP-mannose metabolic process

9525924

HgeneGMDS

GO:0042351

'de novo' GDP-L-fucose biosynthetic process

9525924

TgeneVAPB

GO:0019048

modulation by virus of host morphology or physiology

16227268

TgeneVAPB

GO:0036498

IRE1-mediated unfolded protein response

20940299


check buttonFusion gene breakpoints across GMDS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across VAPB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PAADTCGA-IB-7647-01AGMDSchr6

1930337

-VAPBchr20

57019133

+
ChimerDB4PAADTCGA-IB-7647GMDSchr6

1930336

-VAPBchr20

57019132

+
ChimerDB4PAADTCGA-IB-7647GMDSchr6

1930337

-VAPBchr20

57019133

+
ChimerDB4PAADTCGA-IB-7647GMDSchr6

1960101

-VAPBchr20

57019133

+


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Fusion Gene ORF analysis for GMDS-VAPB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000380815ENST00000265619GMDSchr6

1930337

-VAPBchr20

57019133

+
5CDS-3UTRENST00000380815ENST00000265619GMDSchr6

1930336

-VAPBchr20

57019132

+
5CDS-3UTRENST00000380815ENST00000265619GMDSchr6

1960101

-VAPBchr20

57019133

+
5CDS-3UTRENST00000530927ENST00000265619GMDSchr6

1930337

-VAPBchr20

57019133

+
5CDS-3UTRENST00000530927ENST00000265619GMDSchr6

1930336

-VAPBchr20

57019132

+
5CDS-3UTRENST00000530927ENST00000265619GMDSchr6

1960101

-VAPBchr20

57019133

+
Frame-shiftENST00000380815ENST00000395802GMDSchr6

1930337

-VAPBchr20

57019133

+
Frame-shiftENST00000380815ENST00000395802GMDSchr6

1930336

-VAPBchr20

57019132

+
Frame-shiftENST00000380815ENST00000395802GMDSchr6

1960101

-VAPBchr20

57019133

+
Frame-shiftENST00000380815ENST00000475243GMDSchr6

1930337

-VAPBchr20

57019133

+
Frame-shiftENST00000380815ENST00000475243GMDSchr6

1930336

-VAPBchr20

57019132

+
Frame-shiftENST00000530927ENST00000395802GMDSchr6

1930337

-VAPBchr20

57019133

+
Frame-shiftENST00000530927ENST00000395802GMDSchr6

1930336

-VAPBchr20

57019132

+
Frame-shiftENST00000530927ENST00000395802GMDSchr6

1960101

-VAPBchr20

57019133

+
Frame-shiftENST00000530927ENST00000475243GMDSchr6

1930337

-VAPBchr20

57019133

+
Frame-shiftENST00000530927ENST00000475243GMDSchr6

1930336

-VAPBchr20

57019132

+
In-frameENST00000380815ENST00000475243GMDSchr6

1960101

-VAPBchr20

57019133

+
In-frameENST00000530927ENST00000475243GMDSchr6

1960101

-VAPBchr20

57019133

+
intron-3CDSENST00000467288ENST00000395802GMDSchr6

1930337

-VAPBchr20

57019133

+
intron-3CDSENST00000467288ENST00000395802GMDSchr6

1930336

-VAPBchr20

57019132

+
intron-3CDSENST00000467288ENST00000395802GMDSchr6

1960101

-VAPBchr20

57019133

+
intron-3CDSENST00000467288ENST00000475243GMDSchr6

1930337

-VAPBchr20

57019133

+
intron-3CDSENST00000467288ENST00000475243GMDSchr6

1930336

-VAPBchr20

57019132

+
intron-3CDSENST00000467288ENST00000475243GMDSchr6

1960101

-VAPBchr20

57019133

+
intron-3UTRENST00000467288ENST00000265619GMDSchr6

1930337

-VAPBchr20

57019133

+
intron-3UTRENST00000467288ENST00000265619GMDSchr6

1930336

-VAPBchr20

57019132

+
intron-3UTRENST00000467288ENST00000265619GMDSchr6

1960101

-VAPBchr20

57019133

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000530927GMDSchr61960101-ENST00000475243VAPBchr2057019133+762660148689213
ENST00000380815GMDSchr61960101-ENST00000475243VAPBchr2057019133+7938913421001319

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000530927ENST00000475243GMDSchr61960101-VAPBchr2057019133+0.0008677770.9991322
ENST00000380815ENST00000475243GMDSchr61960101-VAPBchr2057019133+0.0006482070.9993518

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Fusion Genomic Features for GMDS-VAPB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GMDSchr61960100-VAPBchr2057019132+0.899372640.100627355
GMDSchr61930336-VAPBchr2057019132+0.0001164050.99988353
GMDSchr61930336-VAPBchr2057019132+0.0001164050.99988353
GMDSchr61960100-VAPBchr2057019132+0.899372640.100627355
GMDSchr61930336-VAPBchr2057019132+0.0001164050.99988353
GMDSchr61930336-VAPBchr2057019132+0.0001164050.99988353

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GMDS-VAPB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:1930337/chr20:57019133)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGMDSchr6:1960101chr20:57019133ENST00000380815-611108_112214373.0Nucleotide bindingNADP
HgeneGMDSchr6:1960101chr20:57019133ENST00000380815-61130_35214373.0Nucleotide bindingNADP
HgeneGMDSchr6:1960101chr20:57019133ENST00000380815-61155_58214373.0Nucleotide bindingNADP
HgeneGMDSchr6:1960101chr20:57019133ENST00000380815-61186_87214373.0Nucleotide bindingNADP
HgeneGMDSchr6:1960101chr20:57019133ENST00000530927-611108_112184343.0Nucleotide bindingNADP
HgeneGMDSchr6:1960101chr20:57019133ENST00000530927-61130_35184343.0Nucleotide bindingNADP
HgeneGMDSchr6:1960101chr20:57019133ENST00000530927-61155_58184343.0Nucleotide bindingNADP
HgeneGMDSchr6:1960101chr20:57019133ENST00000530927-61186_87184343.0Nucleotide bindingNADP
TgeneVAPBchr6:1960101chr20:57019133ENST0000039580213159_19670100.0Coiled coilOntology_term=ECO:0000255
TgeneVAPBchr6:1960101chr20:57019133ENST0000039580213223_24370100.0TransmembraneHelical%3B Anchor for type IV membrane protein
TgeneVAPBchr6:1960101chr20:57019133ENST0000047524346223_243191244.0TransmembraneHelical%3B Anchor for type IV membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneVAPBchr6:1960101chr20:57019133ENST0000047524346159_196191244.0Coiled coilOntology_term=ECO:0000255
TgeneVAPBchr6:1960101chr20:57019133ENST00000395802137_12470100.0DomainMSP
TgeneVAPBchr6:1960101chr20:57019133ENST00000475243467_124191244.0DomainMSP
TgeneVAPBchr6:1960101chr20:57019133ENST00000395802132_22270100.0Topological domainCytoplasmic
TgeneVAPBchr6:1960101chr20:57019133ENST00000475243462_222191244.0Topological domainCytoplasmic


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Fusion Gene Sequence for GMDS-VAPB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>33475_33475_1_GMDS-VAPB_GMDS_chr6_1960101_ENST00000380815_VAPB_chr20_57019133_ENST00000475243_length(transcript)=7938nt_BP=913nt
GACGCGAATGACGCTGCGCCAGTCAGGCCGCAGCCCCGCTGCTTGGCCCGTCGGGCCCGCCTTGGCCGGCTCGGCCCGCCCCCGGCCCTC
CCTGCACGGCCTCCCGTGCGCCCCTGTCAGACTGTGGCGGCCGGTCGCGCGGTGCGCTCTCCCTCCCTGCCCGCAGCCTGGAGAGGCGCT
TCGTGCTGCACACCCCCGCGTTCCTGCCGGCACCGCGCCTGCCCTCTGCCGCGCTCCGCCCTGCCGCCGACCGCACGCCCGCCGCGGGAC
ATGGCACACGCACCGGCACGCTGCCCCAGCGCCCGGGGCTCCGGGGACGGCGAGATGGGCAAGCCCAGGAACGTGGCGCTCATCACCGGT
ATCACAGGCCAGGATGGTTCCTACCTGGCTGAGTTCCTGCTGGAGAAAGGCTATGAGGTCCATGGAATTGTACGGCGGTCCAGTTCATTT
AATACGGGTCGAATTGAGCATCTGTATAAGAATCCCCAGGCTCACATTGAAGGAAACATGAAGTTGCACTATGGCGATCTCACTGACAGT
ACCTGCCTTGTGAAGATCATTAATGAAGTAAAGCCCACAGAGATCTACAACCTTGGAGCCCAGAGCCACGTCAAAATTTCCTTTGACCTC
GCTGAGTACACTGCGGACGTTGACGGAGTTGGCACTCTACGACTTCTAGATGCAGTTAAGACTTGTGGCCTTATCAACTCTGTGAAGTTC
TACCAAGCCTCAACAAGTGAACTTTATGGGAAAGTGCAGGAAATACCCCAGAAGGAGACCACCCCTTTCTATCCCCGGTCACCCTATGGG
GCAGCAAAACTCTATGCCTATTGGATTGTGGTGAACTTCCGTGAGGCGTATAATCTCTTTGCAGTGAACGGCATTCTCTTCAATCATGAG
AGTCCCAGAAGAGGAAGAAGATGGACTGCGGATGAGGAAGACAGTGCAGAGCAACAGCCCCATTTCAGCATTAGCCCCAACTGGGAAGGA
AGAAGGCCTTAGCACCCGGCTCTTGGCTCTGGTGGTTTTGTTCTTTATCGTTGGTGTAATTATTGGGAAGATTGCCTTGTAGAGGTAGCA
TGCACAGGATGGTAAATTGGATTGGTGGATCCACCATATCATGGGATTTAAATTTATCATAACCATGTGTAAAAAGAAATTAATGTATGA
TGACATCTCACAGGTCTTGCCTTTAAATTACCCCTCCCTGCACACACATACACAGATACACACACACAAATATAATGTAACGATCTTTTA
GAAAGTTAAAAATGTATAGTAACTGATTGAGGGGGAAAAGAATGATCTTTATTAATGACAAGGGAAACCATGAGTAATGCCACAATGGCA
TATTGTAAATGTCATTTTAAACATTGGTAGGCCTTGGTACATGATGCTGGATTACCTCTCTTAAAATGACACCCTTCCTCGCCTGTTGGT
GCTGGCCCTTGGGGAGCTGGAGCCCAGCATGCTGGGGAGTGCGGTCAGCTCCACACAGTAGTCCCCACGTGGCCCACTCCCGGCCCAGGC
TGCTTTCCGTGTCTTCAGTTCTGTCCAAGCCATCAGCTCCTTGGGACTGATGAACAGAGTCAGAAGCCCAAAGGAATTGCACTGTGGCAG
CATCAGACGTACTCGTCATAAGTGAGAGGCGTGTGTTGACTGATTGACCCAGCGCTTTGGAAATAAATGGCAGTGCTTTGTTCACTTAAA
GGGACCAAGCTAAATTTGTATTGGTTCATGTAGTGAAGTCAAACTGTTATTCAGAGATGTTTAATGCATATTTAACTTATTTAATGTATT
TCATCTCATGTTTTCTTATTGTCACAAGAGTACAGTTAATGCTGCGTGCTGCTGAACTCTGTTGGGTGAACTGGTATTGCTGCTGGAGGG
CTGTGGGCTCCTCTGTCTCTGGAGAGTCTGGTCATGTGGAGGTGGGGTTTATTGGGATGCTGGAGAAGAGCTGCCAGGAAGTGTTTTTTC
TGGGTCAGTAAATAACAACTGTCATAGGGAGGGAAATTCTCAGTAGTGACAGTCAACTCTAGGTTACCTTTTTTAATGAAGAGTAGTCAG
TCTTCTAGATTGTTCTTATACCACCTCTCAACCATTACTCACACTTCCAGCGCCCAGGTCCAAGTCTGAGCCTGACCTCCCCTTGGGGAC
CTAGCCTGGAGTCAGGACAAATGGATCGGGCTGCAGAGGGTTAGAAGCGAGGGCACCAGCAGTTGTGGGTGGGGAGCAAGGGAAGAGAGA
AACTCTTCAGCGAATCCTTCTAGTACTAGTTGAGAGTTTGACTGTGAATTAATTTTATGCCATAAAAGACCAACCCAGTTCTGTTTGACT
ATGTAGCATCTTGAAAAGAAAAATTATAATAAAGCCCCAAAATTAAGAATTCTTTTGTCATTTTGTCACATTTGCTCTATGGGGGGAATT
ATTATTTTATCATTTTTATTATTTTGCCATTGGAAGGTTAACTTTAAAATGAGCCCTATCACTGAGAAATACGTGTTTCATGATTTAACT
CTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATTTTTTTTTTGGTTGTCTTCAGCTGACAGTATGAAAAATGAAACTGCTGAA
AAAGCTGAGCACCTGGTCACCCTTGGCCTTCCATTGCTTTGGCCTTCAGTAAAAAGCAGCCTCCCTTCTAGGTCAGGGAACCATGCCATT
GAGACTAGTAACGGGCGTTCTGGGCACAGTCCCACTGTGCACAGGTTTGAGAGGACAAGTTCATCAGAAGGAAGGCAGTCCTTAGAAGTC
ACATACGTTGAGCCACGTTGCTCCTAAGCCTGGCTCTGTCAAGCTGGGTCAGGGGCCTTGAAACTGGAGAAGTGGAAGTCTATGGTTGGT
CTGAGTAAGTAACTTCCTGTCTTCATGAAAAAAGTTGACTTTGAATCCCAGGTACTCACAGAAATGGTGAACAGACTTAGTTGTTACCCA
GGCACCCATGGATTGTGTTGAGTGTGCAGACAGGGAGGCCACCCCAATAGGAATTCGTCTCCAGGATTTTTCCCATGTGTCCCCCAGTAC
TTATAAAAGGGAGTGAAAAGACCGAGCTGTAAGGCATGTGCCTTCTGCCACCTGACTTTCCGTGAGGGGACTAAAATTTACTAATTGTAG
TTGCTGCAGCCAGTTAAGTCCTGTAGCTTCCAGGCCCTCATGTCTTTGATAGGAGAGTGCTTAGGTGGTCCCCAACAGTGCCTAGGGGTA
CAGTACAGTCCCATTACACTAGAGCAGGGCTCTATTTATTTTTAAAGGATATGGCCGTGTGTTTTGATAAAACTTTATTCACAAAAACAG
CCGGGTCATGGGATTTGGCTTGTGAGTCTGTAACAGTTCTTAAAAAGAATATCTGAGAAACTACTCTGTTTTAGACCTTTGAAGGTGATT
TAGAGTTTTGTGTACATCTAGGAGAAGGTGTTCAGCTTCTCAGAGGATGTGGACATTTTGGTTGCAGCTAAAAATCAGTCTCTGAAGTCT
CTCTCCCTTCTAGAGGTTAGGACTTGGTGAACATGTTTGTGGGCCTTTTGACTGAGTGGCAGAAGGAAACTGCTCAGGAAGAGAAACAGG
TGACTGATGGGAAGGTTGATTATTTTCTCAGTCATCCTGGCAGCCAAAAATGTGCCAGGAAAAGAAAGAATGTGGAGCACGCGTGGCTCC
TGGAGGACTTGGAGATGCATGCACATTTAGGGTGTTTTCCCTAGAATTACATAATGAAAAAAAGAATAAGGCAAAGAGGAGGTGAATATG
GGGCCTGTCACAACGGCCTGCCCTGCCCCAAGAGGGTTAAGAGTCAGATAATCGGGACGAAACTGGCATGGAAAGAGCGAGCCTAGGGAG
GATGCCGCTGGGCAGTGTGCATGGGGGAGCTGCTGCCAGGCTGCCCTCCAGTCTGCTCCTGTGGTTACTGGCTCCACAGCACCTCAGAGA
GGGCGGCCCTGGCTTCAGAAATGCCAGCCATAGTGCTCACAAATGCAGAAGAGATGGAAGCGGTGACAGAATCCTGAAAGTTTTTATTGA
TTGAAGTTTTAAATTGGTAACTTAAGCTTCCTTGGCACGATACAAAATACCTCTTAAAGACAGCAGGCTTTTTTATTTGTAGGTGTGAGG
AACTGGCTTTAACTTTTTTCTCCTCCTAGTTTGCATGTTTTCCTTCTCTCGTCTTCTGAACTGCTGGCACCAGCAGTAATACATACTGAT
AAAATCAAAATTGATTTTTACCAGTGGCCAGTTTATGGCTAGAGAGACGACTTATACCTCCATAACACAGAAGGGGGAAAAATGAAGAAC
CTCCAGTGATCCGTGAAAACCTAAACGCTTTCAAACAAATCCCAGGAACAGAATTGCTATCGAAAGATATCATTGCCCAGTTTGCAGGCT
ATGTTGAGTCAGATAGAACTGAATGTAGTGAGAGCTCAGAGCTACAGAGCCTTTCAGATGAATTTGAAAACAGACTCTGTGTGTGTGTGC
ATGTGTGCATGTGTGCATGTGTGGCATATGTGCCGTATGTCAGTAGCTTGACAGTTTTCAAATCGTGCCTATATTTTTTTGCATACACAA
ATTTTTGTGTTTGCAAACTCAGAATCCATGCCAAAATACAATGTTATATGTCATTTTCAGCTCCTTCTCTAAAGGAATGGCCCATTTCTC
ATTGTAGTTTGAGAAATACATGTATGAAGAGATAGGGGTCTTGGGCTTCCCAGTGTCACTTTGAACACCTGAATAACATTTAACTCCTGA
GACCTTCTCGGTGTAGAGGCCACTGCTTCCCCCTGCTGGAGATGGCATTTCATTGAAGGGCCTCTCGTGGCTTTCCCTGCCCCCGGCTGT
CTGGCCTGAAGAAGGAGAAAGAACCAAACTGAACTATGAAAAGTTACCACTCTGAGGAGACCTCTCTTAATTAACACTTGGGGCCATGTT
TGCTGTTGTTGAGAAGGAGTGTTCTCAAAGATGAGCTGGAATGGAATTGTATTTAGAAAGGCCCCTGCAAAGTATATAGATGGATGACTC
TAGTTCATGACATACAAATCCCATAAGGCCAACGACCACTCTTCTGGAACACCAAGAGCAGCTCTGAGATCATGCTGGCCCTACGCGAAT
TGAGTTTCTGTGGCCTAATTGGATTTGGAGAACGCCTTCCCTGGCCCCTTTTCCTCAGACAGATCTGCTCTGATAGGAACCTTTTCAAGA
AAGTTACTGTTGTTTCAATGCCACTCCTTACCTGTATAGAACATTTCCAATACATTCGCTCATTGAACTTAATCCTTGCAACTGTGACTG
GGGGGTAGATGGCTCTGTTTGCATACGAAGAAATAAAGGCTCCAGGAGGTTAAATCGGGCAACTTTTTAGAACTAAATCAGTCTCTGTAA
GGCCTACATTGCTAAGATACCATTTCAGCTCTGAAAATCTGCTTCAGGGAAGTGAGTGGATGAGGCCTTCCTGCCTCAGCTACTCTGCCC
GTCTGTACATCTTTTGTGTCTGCCTCCGTACCTTATTCAGTTATTTTCACACTAAAGTAAGTAGAATTAAGACTGTAGTTCAGATGCTTT
TTCTTTTTCTGTTGGAAACTGAACACACTACAGACAGTGAAAAAAGGTACATATTCCATTTTCTCATTGCCTGAAGATCTCTGCTGATGC
TCCTGGAGAATGACTTTGGGGGCTTTAGAAAGAATATTGCCAGTCCGTCTCGGCAAGGAGATGATGGGAGCGCTTTATATGGAGGCTTTA
CATGACTTGTAAATTAAATGTGAATGAGGGCAGTTGATTAAAATTGGTATTACAGAAGGGCCCTGCTGAGGTTTGAAAACAGCTGAGCTG
CTGATGTCTCAGGCCTTTCCCTGAATTAGCACTGCGGTTCTCCAGGATATCAGCAAAGAGGGCAAGTAATAGAAGCCCCTGATAAGGAGC
GTCAGCCGACAGGCAAGCTTGGGAGGCTGTGGGAATGGGTCTGCCCCCAGCTTCACAGACCTCTTCCTCCAGCCTCTGAATCCCATTAGC
CACAGCCTAGAACATTAGCTGAGCTGCACAAGCTCACCCACCCCTGTGCCAGGGGGCCCTGACCTCCCTCCATGCCATGTTTTTGGCTGT
ATCTACGGCACTTAACAATAGGGGCTTTTTATTTTCATTACAGAGATATTTTGAAAAATTTAAAAGACATGAACTCACATAAACAGTTAT
GGATGATAGTTAAAAGAGAAACGGGTGGAGGTGGATGAGAGGTTGTCTTCATGAATATAATTACTTGAGATTTTTTTTTCTTAATGGAAT
TAGTTTATTAGAAAATGTCTGTGTTAAATCCGTAGAAAAGGAAGAAAAGTGTAGCAACAAAAATGTAGCCATTATCTAACTTGCCATAAA
TATTTGCAGTTATGATACCTTGGAATGTTGCCACGATATGGATTGCTTTGATTAAAAGATGTCAGTTGAATAAAACAGTACTGTGGGAGA
ATCGCTTTCTGCTGCTAGATAAATGCTGATGTTTATTTTTAAACCAGGAAACATTGATCCTGTAACAATGCCCGATTACAATTGCTTTAT
TACACCCCAGGGCTGATGGAGATGTAATCACTTGGCTAATGGATGTGGGTGCAGGACAGATGCTCGCTTGCTGGCCTGCTTTCCTGCTTG
CATTCTGATGAGCTGCAGGAGTGCGCCTGGCCTTCTGCAGGTGGAGCTGCTGTCAGAGCTTCGTTTCACTGATACCCAAAGCCATGTCTG
ACTGAAATAAAACAGGTTCCCTTTTTTTTTCCCTTTGGAAAATGCCAACTAAGGGAGACTAATCAGATATCTTAACACAATTTCATCCAG
GCTTAGTGCTAACAAGATTGCGGGGCTTTTTAGGGTTTAAGAAGATGAGAAATGAGTGTGCACGTTTCACACGTTGACTTGCCGGTTTTT
CCATGTCATACAAAAAAGTCCTGGCTGTTTCTCCGAACTGGCTGCCTGCATTCCCGTCTTTCTTTTGTTTTTAAGAAATAGACTGAATTC
AGCTGTTAATCCTCTAGTACAGTATCCATGTTAAAATGTTTTTCCATTGCATCTTTTATGTGAATTCAAAGGTCAGAATTTATTGTCTGT
GATATTGAGACCATGTGTACAAGAACTACTTTTTGCTTTTCATCATTCACTCCTTAGCAAACGTTTCGTAAGTACCCTCTGTCTGTTTGC
TACTATATGAGGTGCTGCGAAATTAGTGGGCGTGGCTTTTTATATTTTTCATTCGTGTGTAGCCTAAGTAAGGTGACTCAAGATGATACA
CCGAGAGAAAAATGCAAAATATATTTGGTTCTCATTTCTGTTGCTGTCGTTTCCTTTTTAAAGACGATTTATCAACTGCTGCCATTTGGA
ACTTCCTATAAGAAACTAAAAATGATCTATTTCAGTGTTCCTTTCGCCTTTCCTCTGCTTTCTGAATAAATGGTTTCAGTAACCCATGCT
GTTCTCTCCCTATTCTACGTCTTTCTCCCTATGTTGAAAAAAGATTCCCACAGTTTCTGATGTGTGTGTTTATAGTCTTCAATGTATGTT
AACATGTTAGGAACTGAGTATCTTAAGAGATGTCTTAGAATGCTTTAGTTTTCATAATTTGTCCTTTATGTATTTTTCATTGTATTTGCT
GTTTTGACATGGAAGTAATTTAAAAAGTTGGTGCAGGAAAGGACTCTTTACTGTTGCACATTTTGGTTTTCTGATATGTAATAAATTCAT
GGCTTGGCAGCTGACATGATGTTTCCCAGAGAGAAGGAGATGTATTTCTGCAGGGTCCAGACCAAAAGAGCCATTTACAGCATGTTCTCC
CATGTTCCATTATCAGCCTGATGAAACCTGCCCTGCCAAGGCATAAACTTTTGTACTAGCTGTCTCCATATTATGTTCAATAAATTCTGT

>33475_33475_1_GMDS-VAPB_GMDS_chr6_1960101_ENST00000380815_VAPB_chr20_57019133_ENST00000475243_length(amino acids)=319AA_BP=290
MARRARLGRLGPPPALPARPPVRPCQTVAAGRAVRSPSLPAAWRGASCCTPPRSCRHRACPLPRSALPPTARPPRDMAHAPARCPSARGS
GDGEMGKPRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTE
IYNLGAQSHVKISFDLAEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFR

--------------------------------------------------------------
>33475_33475_2_GMDS-VAPB_GMDS_chr6_1960101_ENST00000530927_VAPB_chr20_57019133_ENST00000475243_length(transcript)=7626nt_BP=601nt
TGTACACAGGCAGTTTGTTGGGAGCGTTACCATTGCCTCTGGTTCCTCATGTGTAAAATGGATGGTTCCTACCTGGCTGAGTTCCTGCTG
GAGAAAGGCTATGAGGTCCATGGAATTGTACGGCGGTCCAGTTCATTTAATACGGGTCGAATTGAGCATCTGTATAAGAATCCCCAGGCT
CACATTGAAGGAAACATGAAGTTGCACTATGGCGATCTCACTGACAGTACCTGCCTTGTGAAGATCATTAATGAAGTAAAGCCCACAGAG
ATCTACAACCTTGGAGCCCAGAGCCACGTCAAAATTTCCTTTGACCTCGCTGAGTACACTGCGGACGTTGACGGAGTTGGCACTCTACGA
CTTCTAGATGCAGTTAAGACTTGTGGCCTTATCAACTCTGTGAAGTTCTACCAAGCCTCAACAAGTGAACTTTATGGGAAAGTGCAGGAA
ATACCCCAGAAGGAGACCACCCCTTTCTATCCCCGGTCACCCTATGGGGCAGCAAAACTCTATGCCTATTGGATTGTGGTGAACTTCCGT
GAGGCGTATAATCTCTTTGCAGTGAACGGCATTCTCTTCAATCATGAGAGTCCCAGAAGAGGAAGAAGATGGACTGCGGATGAGGAAGAC
AGTGCAGAGCAACAGCCCCATTTCAGCATTAGCCCCAACTGGGAAGGAAGAAGGCCTTAGCACCCGGCTCTTGGCTCTGGTGGTTTTGTT
CTTTATCGTTGGTGTAATTATTGGGAAGATTGCCTTGTAGAGGTAGCATGCACAGGATGGTAAATTGGATTGGTGGATCCACCATATCAT
GGGATTTAAATTTATCATAACCATGTGTAAAAAGAAATTAATGTATGATGACATCTCACAGGTCTTGCCTTTAAATTACCCCTCCCTGCA
CACACATACACAGATACACACACACAAATATAATGTAACGATCTTTTAGAAAGTTAAAAATGTATAGTAACTGATTGAGGGGGAAAAGAA
TGATCTTTATTAATGACAAGGGAAACCATGAGTAATGCCACAATGGCATATTGTAAATGTCATTTTAAACATTGGTAGGCCTTGGTACAT
GATGCTGGATTACCTCTCTTAAAATGACACCCTTCCTCGCCTGTTGGTGCTGGCCCTTGGGGAGCTGGAGCCCAGCATGCTGGGGAGTGC
GGTCAGCTCCACACAGTAGTCCCCACGTGGCCCACTCCCGGCCCAGGCTGCTTTCCGTGTCTTCAGTTCTGTCCAAGCCATCAGCTCCTT
GGGACTGATGAACAGAGTCAGAAGCCCAAAGGAATTGCACTGTGGCAGCATCAGACGTACTCGTCATAAGTGAGAGGCGTGTGTTGACTG
ATTGACCCAGCGCTTTGGAAATAAATGGCAGTGCTTTGTTCACTTAAAGGGACCAAGCTAAATTTGTATTGGTTCATGTAGTGAAGTCAA
ACTGTTATTCAGAGATGTTTAATGCATATTTAACTTATTTAATGTATTTCATCTCATGTTTTCTTATTGTCACAAGAGTACAGTTAATGC
TGCGTGCTGCTGAACTCTGTTGGGTGAACTGGTATTGCTGCTGGAGGGCTGTGGGCTCCTCTGTCTCTGGAGAGTCTGGTCATGTGGAGG
TGGGGTTTATTGGGATGCTGGAGAAGAGCTGCCAGGAAGTGTTTTTTCTGGGTCAGTAAATAACAACTGTCATAGGGAGGGAAATTCTCA
GTAGTGACAGTCAACTCTAGGTTACCTTTTTTAATGAAGAGTAGTCAGTCTTCTAGATTGTTCTTATACCACCTCTCAACCATTACTCAC
ACTTCCAGCGCCCAGGTCCAAGTCTGAGCCTGACCTCCCCTTGGGGACCTAGCCTGGAGTCAGGACAAATGGATCGGGCTGCAGAGGGTT
AGAAGCGAGGGCACCAGCAGTTGTGGGTGGGGAGCAAGGGAAGAGAGAAACTCTTCAGCGAATCCTTCTAGTACTAGTTGAGAGTTTGAC
TGTGAATTAATTTTATGCCATAAAAGACCAACCCAGTTCTGTTTGACTATGTAGCATCTTGAAAAGAAAAATTATAATAAAGCCCCAAAA
TTAAGAATTCTTTTGTCATTTTGTCACATTTGCTCTATGGGGGGAATTATTATTTTATCATTTTTATTATTTTGCCATTGGAAGGTTAAC
TTTAAAATGAGCCCTATCACTGAGAAATACGTGTTTCATGATTTAACTCTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATTT
TTTTTTTGGTTGTCTTCAGCTGACAGTATGAAAAATGAAACTGCTGAAAAAGCTGAGCACCTGGTCACCCTTGGCCTTCCATTGCTTTGG
CCTTCAGTAAAAAGCAGCCTCCCTTCTAGGTCAGGGAACCATGCCATTGAGACTAGTAACGGGCGTTCTGGGCACAGTCCCACTGTGCAC
AGGTTTGAGAGGACAAGTTCATCAGAAGGAAGGCAGTCCTTAGAAGTCACATACGTTGAGCCACGTTGCTCCTAAGCCTGGCTCTGTCAA
GCTGGGTCAGGGGCCTTGAAACTGGAGAAGTGGAAGTCTATGGTTGGTCTGAGTAAGTAACTTCCTGTCTTCATGAAAAAAGTTGACTTT
GAATCCCAGGTACTCACAGAAATGGTGAACAGACTTAGTTGTTACCCAGGCACCCATGGATTGTGTTGAGTGTGCAGACAGGGAGGCCAC
CCCAATAGGAATTCGTCTCCAGGATTTTTCCCATGTGTCCCCCAGTACTTATAAAAGGGAGTGAAAAGACCGAGCTGTAAGGCATGTGCC
TTCTGCCACCTGACTTTCCGTGAGGGGACTAAAATTTACTAATTGTAGTTGCTGCAGCCAGTTAAGTCCTGTAGCTTCCAGGCCCTCATG
TCTTTGATAGGAGAGTGCTTAGGTGGTCCCCAACAGTGCCTAGGGGTACAGTACAGTCCCATTACACTAGAGCAGGGCTCTATTTATTTT
TAAAGGATATGGCCGTGTGTTTTGATAAAACTTTATTCACAAAAACAGCCGGGTCATGGGATTTGGCTTGTGAGTCTGTAACAGTTCTTA
AAAAGAATATCTGAGAAACTACTCTGTTTTAGACCTTTGAAGGTGATTTAGAGTTTTGTGTACATCTAGGAGAAGGTGTTCAGCTTCTCA
GAGGATGTGGACATTTTGGTTGCAGCTAAAAATCAGTCTCTGAAGTCTCTCTCCCTTCTAGAGGTTAGGACTTGGTGAACATGTTTGTGG
GCCTTTTGACTGAGTGGCAGAAGGAAACTGCTCAGGAAGAGAAACAGGTGACTGATGGGAAGGTTGATTATTTTCTCAGTCATCCTGGCA
GCCAAAAATGTGCCAGGAAAAGAAAGAATGTGGAGCACGCGTGGCTCCTGGAGGACTTGGAGATGCATGCACATTTAGGGTGTTTTCCCT
AGAATTACATAATGAAAAAAAGAATAAGGCAAAGAGGAGGTGAATATGGGGCCTGTCACAACGGCCTGCCCTGCCCCAAGAGGGTTAAGA
GTCAGATAATCGGGACGAAACTGGCATGGAAAGAGCGAGCCTAGGGAGGATGCCGCTGGGCAGTGTGCATGGGGGAGCTGCTGCCAGGCT
GCCCTCCAGTCTGCTCCTGTGGTTACTGGCTCCACAGCACCTCAGAGAGGGCGGCCCTGGCTTCAGAAATGCCAGCCATAGTGCTCACAA
ATGCAGAAGAGATGGAAGCGGTGACAGAATCCTGAAAGTTTTTATTGATTGAAGTTTTAAATTGGTAACTTAAGCTTCCTTGGCACGATA
CAAAATACCTCTTAAAGACAGCAGGCTTTTTTATTTGTAGGTGTGAGGAACTGGCTTTAACTTTTTTCTCCTCCTAGTTTGCATGTTTTC
CTTCTCTCGTCTTCTGAACTGCTGGCACCAGCAGTAATACATACTGATAAAATCAAAATTGATTTTTACCAGTGGCCAGTTTATGGCTAG
AGAGACGACTTATACCTCCATAACACAGAAGGGGGAAAAATGAAGAACCTCCAGTGATCCGTGAAAACCTAAACGCTTTCAAACAAATCC
CAGGAACAGAATTGCTATCGAAAGATATCATTGCCCAGTTTGCAGGCTATGTTGAGTCAGATAGAACTGAATGTAGTGAGAGCTCAGAGC
TACAGAGCCTTTCAGATGAATTTGAAAACAGACTCTGTGTGTGTGTGCATGTGTGCATGTGTGCATGTGTGGCATATGTGCCGTATGTCA
GTAGCTTGACAGTTTTCAAATCGTGCCTATATTTTTTTGCATACACAAATTTTTGTGTTTGCAAACTCAGAATCCATGCCAAAATACAAT
GTTATATGTCATTTTCAGCTCCTTCTCTAAAGGAATGGCCCATTTCTCATTGTAGTTTGAGAAATACATGTATGAAGAGATAGGGGTCTT
GGGCTTCCCAGTGTCACTTTGAACACCTGAATAACATTTAACTCCTGAGACCTTCTCGGTGTAGAGGCCACTGCTTCCCCCTGCTGGAGA
TGGCATTTCATTGAAGGGCCTCTCGTGGCTTTCCCTGCCCCCGGCTGTCTGGCCTGAAGAAGGAGAAAGAACCAAACTGAACTATGAAAA
GTTACCACTCTGAGGAGACCTCTCTTAATTAACACTTGGGGCCATGTTTGCTGTTGTTGAGAAGGAGTGTTCTCAAAGATGAGCTGGAAT
GGAATTGTATTTAGAAAGGCCCCTGCAAAGTATATAGATGGATGACTCTAGTTCATGACATACAAATCCCATAAGGCCAACGACCACTCT
TCTGGAACACCAAGAGCAGCTCTGAGATCATGCTGGCCCTACGCGAATTGAGTTTCTGTGGCCTAATTGGATTTGGAGAACGCCTTCCCT
GGCCCCTTTTCCTCAGACAGATCTGCTCTGATAGGAACCTTTTCAAGAAAGTTACTGTTGTTTCAATGCCACTCCTTACCTGTATAGAAC
ATTTCCAATACATTCGCTCATTGAACTTAATCCTTGCAACTGTGACTGGGGGGTAGATGGCTCTGTTTGCATACGAAGAAATAAAGGCTC
CAGGAGGTTAAATCGGGCAACTTTTTAGAACTAAATCAGTCTCTGTAAGGCCTACATTGCTAAGATACCATTTCAGCTCTGAAAATCTGC
TTCAGGGAAGTGAGTGGATGAGGCCTTCCTGCCTCAGCTACTCTGCCCGTCTGTACATCTTTTGTGTCTGCCTCCGTACCTTATTCAGTT
ATTTTCACACTAAAGTAAGTAGAATTAAGACTGTAGTTCAGATGCTTTTTCTTTTTCTGTTGGAAACTGAACACACTACAGACAGTGAAA
AAAGGTACATATTCCATTTTCTCATTGCCTGAAGATCTCTGCTGATGCTCCTGGAGAATGACTTTGGGGGCTTTAGAAAGAATATTGCCA
GTCCGTCTCGGCAAGGAGATGATGGGAGCGCTTTATATGGAGGCTTTACATGACTTGTAAATTAAATGTGAATGAGGGCAGTTGATTAAA
ATTGGTATTACAGAAGGGCCCTGCTGAGGTTTGAAAACAGCTGAGCTGCTGATGTCTCAGGCCTTTCCCTGAATTAGCACTGCGGTTCTC
CAGGATATCAGCAAAGAGGGCAAGTAATAGAAGCCCCTGATAAGGAGCGTCAGCCGACAGGCAAGCTTGGGAGGCTGTGGGAATGGGTCT
GCCCCCAGCTTCACAGACCTCTTCCTCCAGCCTCTGAATCCCATTAGCCACAGCCTAGAACATTAGCTGAGCTGCACAAGCTCACCCACC
CCTGTGCCAGGGGGCCCTGACCTCCCTCCATGCCATGTTTTTGGCTGTATCTACGGCACTTAACAATAGGGGCTTTTTATTTTCATTACA
GAGATATTTTGAAAAATTTAAAAGACATGAACTCACATAAACAGTTATGGATGATAGTTAAAAGAGAAACGGGTGGAGGTGGATGAGAGG
TTGTCTTCATGAATATAATTACTTGAGATTTTTTTTTCTTAATGGAATTAGTTTATTAGAAAATGTCTGTGTTAAATCCGTAGAAAAGGA
AGAAAAGTGTAGCAACAAAAATGTAGCCATTATCTAACTTGCCATAAATATTTGCAGTTATGATACCTTGGAATGTTGCCACGATATGGA
TTGCTTTGATTAAAAGATGTCAGTTGAATAAAACAGTACTGTGGGAGAATCGCTTTCTGCTGCTAGATAAATGCTGATGTTTATTTTTAA
ACCAGGAAACATTGATCCTGTAACAATGCCCGATTACAATTGCTTTATTACACCCCAGGGCTGATGGAGATGTAATCACTTGGCTAATGG
ATGTGGGTGCAGGACAGATGCTCGCTTGCTGGCCTGCTTTCCTGCTTGCATTCTGATGAGCTGCAGGAGTGCGCCTGGCCTTCTGCAGGT
GGAGCTGCTGTCAGAGCTTCGTTTCACTGATACCCAAAGCCATGTCTGACTGAAATAAAACAGGTTCCCTTTTTTTTTCCCTTTGGAAAA
TGCCAACTAAGGGAGACTAATCAGATATCTTAACACAATTTCATCCAGGCTTAGTGCTAACAAGATTGCGGGGCTTTTTAGGGTTTAAGA
AGATGAGAAATGAGTGTGCACGTTTCACACGTTGACTTGCCGGTTTTTCCATGTCATACAAAAAAGTCCTGGCTGTTTCTCCGAACTGGC
TGCCTGCATTCCCGTCTTTCTTTTGTTTTTAAGAAATAGACTGAATTCAGCTGTTAATCCTCTAGTACAGTATCCATGTTAAAATGTTTT
TCCATTGCATCTTTTATGTGAATTCAAAGGTCAGAATTTATTGTCTGTGATATTGAGACCATGTGTACAAGAACTACTTTTTGCTTTTCA
TCATTCACTCCTTAGCAAACGTTTCGTAAGTACCCTCTGTCTGTTTGCTACTATATGAGGTGCTGCGAAATTAGTGGGCGTGGCTTTTTA
TATTTTTCATTCGTGTGTAGCCTAAGTAAGGTGACTCAAGATGATACACCGAGAGAAAAATGCAAAATATATTTGGTTCTCATTTCTGTT
GCTGTCGTTTCCTTTTTAAAGACGATTTATCAACTGCTGCCATTTGGAACTTCCTATAAGAAACTAAAAATGATCTATTTCAGTGTTCCT
TTCGCCTTTCCTCTGCTTTCTGAATAAATGGTTTCAGTAACCCATGCTGTTCTCTCCCTATTCTACGTCTTTCTCCCTATGTTGAAAAAA
GATTCCCACAGTTTCTGATGTGTGTGTTTATAGTCTTCAATGTATGTTAACATGTTAGGAACTGAGTATCTTAAGAGATGTCTTAGAATG
CTTTAGTTTTCATAATTTGTCCTTTATGTATTTTTCATTGTATTTGCTGTTTTGACATGGAAGTAATTTAAAAAGTTGGTGCAGGAAAGG
ACTCTTTACTGTTGCACATTTTGGTTTTCTGATATGTAATAAATTCATGGCTTGGCAGCTGACATGATGTTTCCCAGAGAGAAGGAGATG
TATTTCTGCAGGGTCCAGACCAAAAGAGCCATTTACAGCATGTTCTCCCATGTTCCATTATCAGCCTGATGAAACCTGCCCTGCCAAGGC

>33475_33475_2_GMDS-VAPB_GMDS_chr6_1960101_ENST00000530927_VAPB_chr20_57019133_ENST00000475243_length(amino acids)=213AA_BP=184
MCKMDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDL
AEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREAYNLFAVNGILFNHE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GMDS-VAPB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GMDS-VAPB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GMDS-VAPB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource