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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AKAP6-EGLN3 (FusionGDB2 ID:3350)

Fusion Gene Summary for AKAP6-EGLN3

check button Fusion gene summary
Fusion gene informationFusion gene name: AKAP6-EGLN3
Fusion gene ID: 3350
HgeneTgene
Gene symbol

AKAP6

EGLN3

Gene ID

9472

112399

Gene nameA-kinase anchoring protein 6egl-9 family hypoxia inducible factor 3
SynonymsADAP100|ADAP6|AKAP100|PRKA6|mAKAPHIFP4H3|HIFPH3|PHD3
Cytomap

14q12

14q13.1

Type of geneprotein-codingprotein-coding
DescriptionA-kinase anchor protein 6A kinase (PRKA) anchor protein 6A-kinase anchor protein 100 kDaAKAP 100AKAP-6protein kinase A anchoring protein 6egl nine homolog 3HIF-PH3HIF-prolyl hydroxylase 3HPH-1HPH-3egl nine-like protein 3 isoformhypoxia-inducible factor prolyl hydroxylase 3prolyl hydroxylase domain-containing protein 3
Modification date2020031320200313
UniProtAcc

Q13023

Q9H6Z9

Ensembl transtripts involved in fusion geneENST00000554449, ENST00000280979, 
ENST00000557272, ENST00000557354, 
ENST00000250457, ENST00000553215, 
ENST00000547327, ENST00000557521, 
Fusion gene scores* DoF score9 X 8 X 4=2885 X 4 X 3=60
# samples 95
** MAII scorelog2(9/288*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AKAP6 [Title/Abstract] AND EGLN3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAKAP6(32903023)-EGLN3(34400421), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAKAP6

GO:0060306

regulation of membrane repolarization

11299204

HgeneAKAP6

GO:0071320

cellular response to cAMP

11299204

HgeneAKAP6

GO:1901381

positive regulation of potassium ion transmembrane transport

11299204

HgeneAKAP6

GO:1902261

positive regulation of delayed rectifier potassium channel activity

11299204

TgeneEGLN3

GO:0018126

protein hydroxylation

19584355

TgeneEGLN3

GO:0018401

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

11598268


check buttonFusion gene breakpoints across AKAP6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EGLN3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-5413-01AAKAP6chr14

32903023

-EGLN3chr14

34400421

-
ChimerDB4GBMTCGA-06-5413-01AAKAP6chr14

32903023

+EGLN3chr14

34400421

-
ChimerDB4GBMTCGA-06-5413AKAP6chr14

32903023

+EGLN3chr14

34400421

-


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Fusion Gene ORF analysis for AKAP6-EGLN3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000554449ENST00000250457AKAP6chr14

32903023

+EGLN3chr14

34400421

-
3UTR-3CDSENST00000554449ENST00000553215AKAP6chr14

32903023

+EGLN3chr14

34400421

-
3UTR-intronENST00000554449ENST00000547327AKAP6chr14

32903023

+EGLN3chr14

34400421

-
3UTR-intronENST00000554449ENST00000557521AKAP6chr14

32903023

+EGLN3chr14

34400421

-
5CDS-intronENST00000280979ENST00000547327AKAP6chr14

32903023

+EGLN3chr14

34400421

-
5CDS-intronENST00000280979ENST00000557521AKAP6chr14

32903023

+EGLN3chr14

34400421

-
5CDS-intronENST00000557272ENST00000547327AKAP6chr14

32903023

+EGLN3chr14

34400421

-
5CDS-intronENST00000557272ENST00000557521AKAP6chr14

32903023

+EGLN3chr14

34400421

-
5CDS-intronENST00000557354ENST00000547327AKAP6chr14

32903023

+EGLN3chr14

34400421

-
5CDS-intronENST00000557354ENST00000557521AKAP6chr14

32903023

+EGLN3chr14

34400421

-
In-frameENST00000280979ENST00000250457AKAP6chr14

32903023

+EGLN3chr14

34400421

-
In-frameENST00000280979ENST00000553215AKAP6chr14

32903023

+EGLN3chr14

34400421

-
In-frameENST00000557272ENST00000250457AKAP6chr14

32903023

+EGLN3chr14

34400421

-
In-frameENST00000557272ENST00000553215AKAP6chr14

32903023

+EGLN3chr14

34400421

-
In-frameENST00000557354ENST00000250457AKAP6chr14

32903023

+EGLN3chr14

34400421

-
In-frameENST00000557354ENST00000553215AKAP6chr14

32903023

+EGLN3chr14

34400421

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000280979AKAP6chr1432903023+ENST00000250457EGLN3chr1434400421-2517494170856228
ENST00000280979AKAP6chr1432903023+ENST00000553215EGLN3chr1434400421-1349494170856228
ENST00000557354AKAP6chr1432903023+ENST00000250457EGLN3chr1434400421-244642399785228
ENST00000557354AKAP6chr1432903023+ENST00000553215EGLN3chr1434400421-127842399785228
ENST00000557272AKAP6chr1432903023+ENST00000250457EGLN3chr1434400421-239036743729228
ENST00000557272AKAP6chr1432903023+ENST00000553215EGLN3chr1434400421-122236743729228

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000280979ENST00000250457AKAP6chr1432903023+EGLN3chr1434400421-0.0005407680.9994592
ENST00000280979ENST00000553215AKAP6chr1432903023+EGLN3chr1434400421-0.0005115280.9994885
ENST00000557354ENST00000250457AKAP6chr1432903023+EGLN3chr1434400421-0.0004510880.99954885
ENST00000557354ENST00000553215AKAP6chr1432903023+EGLN3chr1434400421-0.0004754110.9995246
ENST00000557272ENST00000250457AKAP6chr1432903023+EGLN3chr1434400421-0.0005115960.99948835
ENST00000557272ENST00000553215AKAP6chr1432903023+EGLN3chr1434400421-0.0005127350.9994873

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Fusion Genomic Features for AKAP6-EGLN3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AKAP6-EGLN3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:32903023/chr14:34400421)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AKAP6

Q13023

EGLN3

Q9H6Z9

FUNCTION: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes.FUNCTION: Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as PKM, TELO2, ATF4 and HIF1A (PubMed:19584355, PubMed:21620138, PubMed:21483450, PubMed:22797300, PubMed:20978507, PubMed:21575608). Target proteins are preferentially recognized via a LXXLAP motif. Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed:11595184, PubMed:12181324). Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (PubMed:11595184, PubMed:12181324). Also hydroxylates HIF2A (PubMed:11595184, PubMed:12181324). Has a preference for the CODD site for both HIF1A and HIF2A (PubMed:11595184, PubMed:12181324). Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site (PubMed:11595184, PubMed:12181324). Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:11595184, PubMed:12181324). Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (PubMed:11595184, PubMed:12181324). ELGN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia. Also hydroxylates PKM in hypoxia, limiting glycolysis (PubMed:21620138, PubMed:21483450). Under normoxia, hydroxylates and regulates the stability of ADRB2 (PubMed:19584355). Regulator of cardiomyocyte and neuronal apoptosis. In cardiomyocytes, inhibits the anti-apoptotic effect of BCL2 by disrupting the BAX-BCL2 complex (PubMed:20849813). In neurons, has a NGF-induced proapoptotic effect, probably through regulating CASP3 activity (PubMed:16098468). Also essential for hypoxic regulation of neutrophilic inflammation (PubMed:21317538). Plays a crucial role in DNA damage response (DDR) by hydroxylating TELO2, promoting its interaction with ATR which is required for activation of the ATR/CHK1/p53 pathway (PubMed:22797300). Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (Probable). {ECO:0000269|PubMed:11595184, ECO:0000269|PubMed:12181324, ECO:0000269|PubMed:16098468, ECO:0000269|PubMed:19584355, ECO:0000269|PubMed:20849813, ECO:0000269|PubMed:20978507, ECO:0000269|PubMed:21317538, ECO:0000269|PubMed:21483450, ECO:0000269|PubMed:21575608, ECO:0000269|PubMed:21620138, ECO:0000269|PubMed:22797300, ECO:0000305|PubMed:17684156}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEGLN3chr14:32903023chr14:34400421ENST0000025045705116_214119240.0DomainFe2OG dioxygenase

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAKAP6chr14:32903023chr14:34400421ENST00000280979+2141560_17011082779.3333333333335Compositional biasNote=Ser-rich
HgeneAKAP6chr14:32903023chr14:34400421ENST00000280979+2142063_20761082779.3333333333335RegionNote=PKA-RII subunit binding domain
HgeneAKAP6chr14:32903023chr14:34400421ENST00000280979+2141036_11501082779.3333333333335RepeatNote=Spectrin 2
HgeneAKAP6chr14:32903023chr14:34400421ENST00000280979+214762_8481082779.3333333333335RepeatNote=Spectrin 1
TgeneEGLN3chr14:32903023chr14:34400421ENST000002504570562_73119240.0RegionBeta(2)beta(3) 'finger-like' loop


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Fusion Gene Sequence for AKAP6-EGLN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3350_3350_1_AKAP6-EGLN3_AKAP6_chr14_32903023_ENST00000280979_EGLN3_chr14_34400421_ENST00000250457_length(transcript)=2517nt_BP=494nt
AGTCTTTCCCATAATGAGCTGCATCATCTGAACTGATGTCACAGCATCATGCAGCAGGTCAAACAAGGCATCTCCTAGTATTGCATCCTA
CAGATGTGCTGTAAACATCAAAAGAAGACGGTGGGATCAGGAGATGCTGTTTTGGAAAGAAGTGAGGTTTAGACTTCTCCATGTTAACCA
TGAGCGTGACACTTTCCCCCCTGAGGTCACAGGACCTGGATCCCATGGCTACTGATGCTTCACCCATGGCCATCAACATGACACCCACTG
TGGAGCAGGGTGAGGGAGAAGAGGCAATGAAGGACATGGACTCTGACCAGCAGTATGAAAAGCCACCCCCACTACACACAGGGGCTGACT
GGAAGATTGTCCTCCACTTACCTGAAATTGAGACCTGGCTCCGGATGACCTCAGAGAGGGTCCGAGACCTAACCTATTCAGTCCAGCAGG
ATTCGGACAGCAAGCATGTGGATGTACATCTAGTTCAACTAAAGGCAATGGTGGCTTGCTATCCGGGAAATGGAACAGGTTATGTTCGCC
ACGTGGACAACCCCAACGGTGATGGTCGCTGCATCACCTGCATCTACTATCTGAACAAGAATTGGGATGCCAAGCTACATGGTGGGATCC
TGCGGATATTTCCAGAGGGGAAATCATTCATAGCAGATGTGGAGCCCATTTTTGACAGACTCCTGTTCTTCTGGTCAGATCGTAGGAACC
CACACGAAGTGCAGCCCTCTTACGCAACCAGATATGCTATGACTGTCTGGTACTTTGATGCTGAAGAAAGGGCAGAAGCCAAAAAGAAAT
TCAGGAATTTAACTAGGAAAACTGAATCTGCCCTCACTGAAGACTGACCGTGCTCTGAAATCTGCTGGCCTTGTTCATTTTAGTAACGGT
TCCTGAATTCTCTTAAATTCTTTGAGATCCAAAGATGGCCTCTTCAGTGACAACAATCTCCCTGCTACTTCTTGCATCCTTCACATCCCT
GTCTTGTGTGTGGTACTTCATGTTTTCTTGCCAAGACTGTGTTGATCTTCAGATACTCTCTTTGCCAGATGAAGTTACTTGCTAACTCCA
GAAATTCCTGCAGACATCCTACTCGGCCAGCGGTTTACCTGATAGATTCGGTAATACTATCAAGAGAAGAGCCTAGGAGCACAGCGAGGG
AATGAACCTTACTTGCACTTTATGTATACTTCCTGATTTGAAAGGAGGAGGTTTGAAAAGAAAAAAATGGAGGTGGTAGATGCCACAGAG
AGGCATCACGGAAGCCTTAACAGCAGGAAACAGAGAAATTTGTGTCATCTGAACAATTTCCAGATGTTCTTAATCCAGGGCTGTTGGGGT
TTCTGGAGAATTATCACAACCTAATGACATTAATACCTCTAGAAAGGGCTGCTGTCATAGTGAACAATTTATAAGTGTCCCATGGGGCAG
ACACTCCTTTTTTCCCAGTCCTGCAACCTGGATTTTCTGCCTCAGCCCCATTTTGCTGAAAATAATGACTTTCTGAATAAAGATGGCAAC
ACAATTTTTTCTCCATTTTCAGTTCTTACCTGGGAACCTAATTCCCCAGAAGCTAAAAAACTAGACATTAGTTGTTTTGGTTGCTTTGTT
GGAATGGAATTTAAATTTAAATGAAAGGAAAAATATATCCCTGGTAGTTTTGTGTTAACCACTGATAACTGTGGAAAGAGCTAGGTCTAC
TGATATACAATAAACATGTGTGCATCTTGAACAATTTGAGAGGGGAGGTGGAGTTGGAAATGTGGGTGTTCCTGTTTTTTTTTTTTTTTT
TTTTTTAGTTTTCCTTTTTAATGAGCTCACCCTTTAACACAAAAAAAGCAAGGTGATGTATTTTAAAAAAGGAAGTGGAAATAAAAAAAT
CTCAAAGCTATTTGAGTTCTCGTCTGTCCCTAGCAGTCTTTCTTCAGCTCACTTGGCTCTCTAGATCCACTGTGGTTGGCAGTATGACCA
GAATCATGGAATTTGCTAGAACTGTGGAAGCTTCTACTCCTGCAGTAAGCACAGATCGCACTGCCTCAATAACTTGGTATTGAGCACGTA
TTTTGCAAAAGCTACTTTTCCTAGTTTTCAGTATTACTTTCATGTTTTAAAAATCCCTTTAATTTCTTGCTTGAAAATCCCATGAACATT
AAAGAGCCAGAAATATTTTCCTTTGTTATGTACGGATATATATATATATAGTCTTCCAAGATAGAAGTTTACTTTTTCCTCTTCTGGTTT
TGGAAAATTTCCAGATAAGACATGTCACCATTAATTCTCAACGACTGCTCTATTTTGTTGTACGGTAATAGTTATCACCTTCTAAATTAC
TATGTAATTTATTCACTTATTATGTTTATTGTCTTGTATCCTTTCTCTGGAGTGTAAGCACAATGAAGACAGGAATTTTGTATATTTTTA

>3350_3350_1_AKAP6-EGLN3_AKAP6_chr14_32903023_ENST00000280979_EGLN3_chr14_34400421_ENST00000250457_length(amino acids)=228AA_BP=108
MLTMSVTLSPLRSQDLDPMATDASPMAINMTPTVEQGEGEEAMKDMDSDQQYEKPPPLHTGADWKIVLHLPEIETWLRMTSERVRDLTYS
VQQDSDSKHVDVHLVQLKAMVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKLHGGILRIFPEGKSFIADVEPIFDRLLFFWSD

--------------------------------------------------------------
>3350_3350_2_AKAP6-EGLN3_AKAP6_chr14_32903023_ENST00000280979_EGLN3_chr14_34400421_ENST00000553215_length(transcript)=1349nt_BP=494nt
AGTCTTTCCCATAATGAGCTGCATCATCTGAACTGATGTCACAGCATCATGCAGCAGGTCAAACAAGGCATCTCCTAGTATTGCATCCTA
CAGATGTGCTGTAAACATCAAAAGAAGACGGTGGGATCAGGAGATGCTGTTTTGGAAAGAAGTGAGGTTTAGACTTCTCCATGTTAACCA
TGAGCGTGACACTTTCCCCCCTGAGGTCACAGGACCTGGATCCCATGGCTACTGATGCTTCACCCATGGCCATCAACATGACACCCACTG
TGGAGCAGGGTGAGGGAGAAGAGGCAATGAAGGACATGGACTCTGACCAGCAGTATGAAAAGCCACCCCCACTACACACAGGGGCTGACT
GGAAGATTGTCCTCCACTTACCTGAAATTGAGACCTGGCTCCGGATGACCTCAGAGAGGGTCCGAGACCTAACCTATTCAGTCCAGCAGG
ATTCGGACAGCAAGCATGTGGATGTACATCTAGTTCAACTAAAGGCAATGGTGGCTTGCTATCCGGGAAATGGAACAGGTTATGTTCGCC
ACGTGGACAACCCCAACGGTGATGGTCGCTGCATCACCTGCATCTACTATCTGAACAAGAATTGGGATGCCAAGCTACATGGTGGGATCC
TGCGGATATTTCCAGAGGGGAAATCATTCATAGCAGATGTGGAGCCCATTTTTGACAGACTCCTGTTCTTCTGGTCAGATCGTAGGAACC
CACACGAAGTGCAGCCCTCTTACGCAACCAGATATGCTATGACTGTCTGGTACTTTGATGCTGAAGAAAGGGCAGAAGCCAAAAAGAAAT
TCAGGAATTTAACTAGGAAAACTGAATCTGCCCTCACTGAAGACTGACCGTGCTCTGAAATCTGCTGGCCTTGTTCATTTTAGTAACGGT
TCCTGAATTCTCTTAAATTCTTTGAGATCCAAAGATGGCCTCTTCAGTGACAACAATCTCCCTGCTACTTCTTGCATCCTTCACATCCCT
GTCTTGTGTGTGGTACTTCATGTTTTCTTGCCAAGACTGTGTTGATCTTCAGATACTCTCTTTGCCAGATGAAGTTACTTGCTAACTCCA
GAAATTCCTGCAGACATCCTACTCGGCCAGCGGTTTACCTGATAGATTCGGTAATACTATCAAGAGAAGAGCCTAGGAGCACAGCGAGGG
AATGAACCTTACTTGCACTTTATGTATACTTCCTGATTTGAAAGGAGGAGGTTTGAAAAGAAAAAAATGGAGGTGGTAGATGCCACAGAG

>3350_3350_2_AKAP6-EGLN3_AKAP6_chr14_32903023_ENST00000280979_EGLN3_chr14_34400421_ENST00000553215_length(amino acids)=228AA_BP=108
MLTMSVTLSPLRSQDLDPMATDASPMAINMTPTVEQGEGEEAMKDMDSDQQYEKPPPLHTGADWKIVLHLPEIETWLRMTSERVRDLTYS
VQQDSDSKHVDVHLVQLKAMVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKLHGGILRIFPEGKSFIADVEPIFDRLLFFWSD

--------------------------------------------------------------
>3350_3350_3_AKAP6-EGLN3_AKAP6_chr14_32903023_ENST00000557272_EGLN3_chr14_34400421_ENST00000250457_length(transcript)=2390nt_BP=367nt
CAGGAGATGCTGTTTTGGAAAGAAGTGAGGTTTAGACTTCTCCATGTTAACCATGAGCGTGACACTTTCCCCCCTGAGGTCACAGGACCT
GGATCCCATGGCTACTGATGCTTCACCCATGGCCATCAACATGACACCCACTGTGGAGCAGGGTGAGGGAGAAGAGGCAATGAAGGACAT
GGACTCTGACCAGCAGTATGAAAAGCCACCCCCACTACACACAGGGGCTGACTGGAAGATTGTCCTCCACTTACCTGAAATTGAGACCTG
GCTCCGGATGACCTCAGAGAGGGTCCGAGACCTAACCTATTCAGTCCAGCAGGATTCGGACAGCAAGCATGTGGATGTACATCTAGTTCA
ACTAAAGGCAATGGTGGCTTGCTATCCGGGAAATGGAACAGGTTATGTTCGCCACGTGGACAACCCCAACGGTGATGGTCGCTGCATCAC
CTGCATCTACTATCTGAACAAGAATTGGGATGCCAAGCTACATGGTGGGATCCTGCGGATATTTCCAGAGGGGAAATCATTCATAGCAGA
TGTGGAGCCCATTTTTGACAGACTCCTGTTCTTCTGGTCAGATCGTAGGAACCCACACGAAGTGCAGCCCTCTTACGCAACCAGATATGC
TATGACTGTCTGGTACTTTGATGCTGAAGAAAGGGCAGAAGCCAAAAAGAAATTCAGGAATTTAACTAGGAAAACTGAATCTGCCCTCAC
TGAAGACTGACCGTGCTCTGAAATCTGCTGGCCTTGTTCATTTTAGTAACGGTTCCTGAATTCTCTTAAATTCTTTGAGATCCAAAGATG
GCCTCTTCAGTGACAACAATCTCCCTGCTACTTCTTGCATCCTTCACATCCCTGTCTTGTGTGTGGTACTTCATGTTTTCTTGCCAAGAC
TGTGTTGATCTTCAGATACTCTCTTTGCCAGATGAAGTTACTTGCTAACTCCAGAAATTCCTGCAGACATCCTACTCGGCCAGCGGTTTA
CCTGATAGATTCGGTAATACTATCAAGAGAAGAGCCTAGGAGCACAGCGAGGGAATGAACCTTACTTGCACTTTATGTATACTTCCTGAT
TTGAAAGGAGGAGGTTTGAAAAGAAAAAAATGGAGGTGGTAGATGCCACAGAGAGGCATCACGGAAGCCTTAACAGCAGGAAACAGAGAA
ATTTGTGTCATCTGAACAATTTCCAGATGTTCTTAATCCAGGGCTGTTGGGGTTTCTGGAGAATTATCACAACCTAATGACATTAATACC
TCTAGAAAGGGCTGCTGTCATAGTGAACAATTTATAAGTGTCCCATGGGGCAGACACTCCTTTTTTCCCAGTCCTGCAACCTGGATTTTC
TGCCTCAGCCCCATTTTGCTGAAAATAATGACTTTCTGAATAAAGATGGCAACACAATTTTTTCTCCATTTTCAGTTCTTACCTGGGAAC
CTAATTCCCCAGAAGCTAAAAAACTAGACATTAGTTGTTTTGGTTGCTTTGTTGGAATGGAATTTAAATTTAAATGAAAGGAAAAATATA
TCCCTGGTAGTTTTGTGTTAACCACTGATAACTGTGGAAAGAGCTAGGTCTACTGATATACAATAAACATGTGTGCATCTTGAACAATTT
GAGAGGGGAGGTGGAGTTGGAAATGTGGGTGTTCCTGTTTTTTTTTTTTTTTTTTTTTTAGTTTTCCTTTTTAATGAGCTCACCCTTTAA
CACAAAAAAAGCAAGGTGATGTATTTTAAAAAAGGAAGTGGAAATAAAAAAATCTCAAAGCTATTTGAGTTCTCGTCTGTCCCTAGCAGT
CTTTCTTCAGCTCACTTGGCTCTCTAGATCCACTGTGGTTGGCAGTATGACCAGAATCATGGAATTTGCTAGAACTGTGGAAGCTTCTAC
TCCTGCAGTAAGCACAGATCGCACTGCCTCAATAACTTGGTATTGAGCACGTATTTTGCAAAAGCTACTTTTCCTAGTTTTCAGTATTAC
TTTCATGTTTTAAAAATCCCTTTAATTTCTTGCTTGAAAATCCCATGAACATTAAAGAGCCAGAAATATTTTCCTTTGTTATGTACGGAT
ATATATATATATAGTCTTCCAAGATAGAAGTTTACTTTTTCCTCTTCTGGTTTTGGAAAATTTCCAGATAAGACATGTCACCATTAATTC
TCAACGACTGCTCTATTTTGTTGTACGGTAATAGTTATCACCTTCTAAATTACTATGTAATTTATTCACTTATTATGTTTATTGTCTTGT
ATCCTTTCTCTGGAGTGTAAGCACAATGAAGACAGGAATTTTGTATATTTTTAACCAATGCAACATACTCTCAGCACCTAAAATAGTGCC

>3350_3350_3_AKAP6-EGLN3_AKAP6_chr14_32903023_ENST00000557272_EGLN3_chr14_34400421_ENST00000250457_length(amino acids)=228AA_BP=108
MLTMSVTLSPLRSQDLDPMATDASPMAINMTPTVEQGEGEEAMKDMDSDQQYEKPPPLHTGADWKIVLHLPEIETWLRMTSERVRDLTYS
VQQDSDSKHVDVHLVQLKAMVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKLHGGILRIFPEGKSFIADVEPIFDRLLFFWSD

--------------------------------------------------------------
>3350_3350_4_AKAP6-EGLN3_AKAP6_chr14_32903023_ENST00000557272_EGLN3_chr14_34400421_ENST00000553215_length(transcript)=1222nt_BP=367nt
CAGGAGATGCTGTTTTGGAAAGAAGTGAGGTTTAGACTTCTCCATGTTAACCATGAGCGTGACACTTTCCCCCCTGAGGTCACAGGACCT
GGATCCCATGGCTACTGATGCTTCACCCATGGCCATCAACATGACACCCACTGTGGAGCAGGGTGAGGGAGAAGAGGCAATGAAGGACAT
GGACTCTGACCAGCAGTATGAAAAGCCACCCCCACTACACACAGGGGCTGACTGGAAGATTGTCCTCCACTTACCTGAAATTGAGACCTG
GCTCCGGATGACCTCAGAGAGGGTCCGAGACCTAACCTATTCAGTCCAGCAGGATTCGGACAGCAAGCATGTGGATGTACATCTAGTTCA
ACTAAAGGCAATGGTGGCTTGCTATCCGGGAAATGGAACAGGTTATGTTCGCCACGTGGACAACCCCAACGGTGATGGTCGCTGCATCAC
CTGCATCTACTATCTGAACAAGAATTGGGATGCCAAGCTACATGGTGGGATCCTGCGGATATTTCCAGAGGGGAAATCATTCATAGCAGA
TGTGGAGCCCATTTTTGACAGACTCCTGTTCTTCTGGTCAGATCGTAGGAACCCACACGAAGTGCAGCCCTCTTACGCAACCAGATATGC
TATGACTGTCTGGTACTTTGATGCTGAAGAAAGGGCAGAAGCCAAAAAGAAATTCAGGAATTTAACTAGGAAAACTGAATCTGCCCTCAC
TGAAGACTGACCGTGCTCTGAAATCTGCTGGCCTTGTTCATTTTAGTAACGGTTCCTGAATTCTCTTAAATTCTTTGAGATCCAAAGATG
GCCTCTTCAGTGACAACAATCTCCCTGCTACTTCTTGCATCCTTCACATCCCTGTCTTGTGTGTGGTACTTCATGTTTTCTTGCCAAGAC
TGTGTTGATCTTCAGATACTCTCTTTGCCAGATGAAGTTACTTGCTAACTCCAGAAATTCCTGCAGACATCCTACTCGGCCAGCGGTTTA
CCTGATAGATTCGGTAATACTATCAAGAGAAGAGCCTAGGAGCACAGCGAGGGAATGAACCTTACTTGCACTTTATGTATACTTCCTGAT
TTGAAAGGAGGAGGTTTGAAAAGAAAAAAATGGAGGTGGTAGATGCCACAGAGAGGCATCACGGAAGCCTTAACAGCAGGAAACAGAGAA

>3350_3350_4_AKAP6-EGLN3_AKAP6_chr14_32903023_ENST00000557272_EGLN3_chr14_34400421_ENST00000553215_length(amino acids)=228AA_BP=108
MLTMSVTLSPLRSQDLDPMATDASPMAINMTPTVEQGEGEEAMKDMDSDQQYEKPPPLHTGADWKIVLHLPEIETWLRMTSERVRDLTYS
VQQDSDSKHVDVHLVQLKAMVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKLHGGILRIFPEGKSFIADVEPIFDRLLFFWSD

--------------------------------------------------------------
>3350_3350_5_AKAP6-EGLN3_AKAP6_chr14_32903023_ENST00000557354_EGLN3_chr14_34400421_ENST00000250457_length(transcript)=2446nt_BP=423nt
CTCCTAGTATTGCATCCTACAGATGTGCTGTAAACATCAAAAGAAGACGGTGGGATCAGGAGATGCTGTTTTGGAAAGAAGTGAGGTTTA
GACTTCTCCATGTTAACCATGAGCGTGACACTTTCCCCCCTGAGGTCACAGGACCTGGATCCCATGGCTACTGATGCTTCACCCATGGCC
ATCAACATGACACCCACTGTGGAGCAGGGTGAGGGAGAAGAGGCAATGAAGGACATGGACTCTGACCAGCAGTATGAAAAGCCACCCCCA
CTACACACAGGGGCTGACTGGAAGATTGTCCTCCACTTACCTGAAATTGAGACCTGGCTCCGGATGACCTCAGAGAGGGTCCGAGACCTA
ACCTATTCAGTCCAGCAGGATTCGGACAGCAAGCATGTGGATGTACATCTAGTTCAACTAAAGGCAATGGTGGCTTGCTATCCGGGAAAT
GGAACAGGTTATGTTCGCCACGTGGACAACCCCAACGGTGATGGTCGCTGCATCACCTGCATCTACTATCTGAACAAGAATTGGGATGCC
AAGCTACATGGTGGGATCCTGCGGATATTTCCAGAGGGGAAATCATTCATAGCAGATGTGGAGCCCATTTTTGACAGACTCCTGTTCTTC
TGGTCAGATCGTAGGAACCCACACGAAGTGCAGCCCTCTTACGCAACCAGATATGCTATGACTGTCTGGTACTTTGATGCTGAAGAAAGG
GCAGAAGCCAAAAAGAAATTCAGGAATTTAACTAGGAAAACTGAATCTGCCCTCACTGAAGACTGACCGTGCTCTGAAATCTGCTGGCCT
TGTTCATTTTAGTAACGGTTCCTGAATTCTCTTAAATTCTTTGAGATCCAAAGATGGCCTCTTCAGTGACAACAATCTCCCTGCTACTTC
TTGCATCCTTCACATCCCTGTCTTGTGTGTGGTACTTCATGTTTTCTTGCCAAGACTGTGTTGATCTTCAGATACTCTCTTTGCCAGATG
AAGTTACTTGCTAACTCCAGAAATTCCTGCAGACATCCTACTCGGCCAGCGGTTTACCTGATAGATTCGGTAATACTATCAAGAGAAGAG
CCTAGGAGCACAGCGAGGGAATGAACCTTACTTGCACTTTATGTATACTTCCTGATTTGAAAGGAGGAGGTTTGAAAAGAAAAAAATGGA
GGTGGTAGATGCCACAGAGAGGCATCACGGAAGCCTTAACAGCAGGAAACAGAGAAATTTGTGTCATCTGAACAATTTCCAGATGTTCTT
AATCCAGGGCTGTTGGGGTTTCTGGAGAATTATCACAACCTAATGACATTAATACCTCTAGAAAGGGCTGCTGTCATAGTGAACAATTTA
TAAGTGTCCCATGGGGCAGACACTCCTTTTTTCCCAGTCCTGCAACCTGGATTTTCTGCCTCAGCCCCATTTTGCTGAAAATAATGACTT
TCTGAATAAAGATGGCAACACAATTTTTTCTCCATTTTCAGTTCTTACCTGGGAACCTAATTCCCCAGAAGCTAAAAAACTAGACATTAG
TTGTTTTGGTTGCTTTGTTGGAATGGAATTTAAATTTAAATGAAAGGAAAAATATATCCCTGGTAGTTTTGTGTTAACCACTGATAACTG
TGGAAAGAGCTAGGTCTACTGATATACAATAAACATGTGTGCATCTTGAACAATTTGAGAGGGGAGGTGGAGTTGGAAATGTGGGTGTTC
CTGTTTTTTTTTTTTTTTTTTTTTTAGTTTTCCTTTTTAATGAGCTCACCCTTTAACACAAAAAAAGCAAGGTGATGTATTTTAAAAAAG
GAAGTGGAAATAAAAAAATCTCAAAGCTATTTGAGTTCTCGTCTGTCCCTAGCAGTCTTTCTTCAGCTCACTTGGCTCTCTAGATCCACT
GTGGTTGGCAGTATGACCAGAATCATGGAATTTGCTAGAACTGTGGAAGCTTCTACTCCTGCAGTAAGCACAGATCGCACTGCCTCAATA
ACTTGGTATTGAGCACGTATTTTGCAAAAGCTACTTTTCCTAGTTTTCAGTATTACTTTCATGTTTTAAAAATCCCTTTAATTTCTTGCT
TGAAAATCCCATGAACATTAAAGAGCCAGAAATATTTTCCTTTGTTATGTACGGATATATATATATATAGTCTTCCAAGATAGAAGTTTA
CTTTTTCCTCTTCTGGTTTTGGAAAATTTCCAGATAAGACATGTCACCATTAATTCTCAACGACTGCTCTATTTTGTTGTACGGTAATAG
TTATCACCTTCTAAATTACTATGTAATTTATTCACTTATTATGTTTATTGTCTTGTATCCTTTCTCTGGAGTGTAAGCACAATGAAGACA
GGAATTTTGTATATTTTTAACCAATGCAACATACTCTCAGCACCTAAAATAGTGCCGGGAACATAGTAAGGGCTCAGTAAATACTTGTTG

>3350_3350_5_AKAP6-EGLN3_AKAP6_chr14_32903023_ENST00000557354_EGLN3_chr14_34400421_ENST00000250457_length(amino acids)=228AA_BP=108
MLTMSVTLSPLRSQDLDPMATDASPMAINMTPTVEQGEGEEAMKDMDSDQQYEKPPPLHTGADWKIVLHLPEIETWLRMTSERVRDLTYS
VQQDSDSKHVDVHLVQLKAMVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKLHGGILRIFPEGKSFIADVEPIFDRLLFFWSD

--------------------------------------------------------------
>3350_3350_6_AKAP6-EGLN3_AKAP6_chr14_32903023_ENST00000557354_EGLN3_chr14_34400421_ENST00000553215_length(transcript)=1278nt_BP=423nt
CTCCTAGTATTGCATCCTACAGATGTGCTGTAAACATCAAAAGAAGACGGTGGGATCAGGAGATGCTGTTTTGGAAAGAAGTGAGGTTTA
GACTTCTCCATGTTAACCATGAGCGTGACACTTTCCCCCCTGAGGTCACAGGACCTGGATCCCATGGCTACTGATGCTTCACCCATGGCC
ATCAACATGACACCCACTGTGGAGCAGGGTGAGGGAGAAGAGGCAATGAAGGACATGGACTCTGACCAGCAGTATGAAAAGCCACCCCCA
CTACACACAGGGGCTGACTGGAAGATTGTCCTCCACTTACCTGAAATTGAGACCTGGCTCCGGATGACCTCAGAGAGGGTCCGAGACCTA
ACCTATTCAGTCCAGCAGGATTCGGACAGCAAGCATGTGGATGTACATCTAGTTCAACTAAAGGCAATGGTGGCTTGCTATCCGGGAAAT
GGAACAGGTTATGTTCGCCACGTGGACAACCCCAACGGTGATGGTCGCTGCATCACCTGCATCTACTATCTGAACAAGAATTGGGATGCC
AAGCTACATGGTGGGATCCTGCGGATATTTCCAGAGGGGAAATCATTCATAGCAGATGTGGAGCCCATTTTTGACAGACTCCTGTTCTTC
TGGTCAGATCGTAGGAACCCACACGAAGTGCAGCCCTCTTACGCAACCAGATATGCTATGACTGTCTGGTACTTTGATGCTGAAGAAAGG
GCAGAAGCCAAAAAGAAATTCAGGAATTTAACTAGGAAAACTGAATCTGCCCTCACTGAAGACTGACCGTGCTCTGAAATCTGCTGGCCT
TGTTCATTTTAGTAACGGTTCCTGAATTCTCTTAAATTCTTTGAGATCCAAAGATGGCCTCTTCAGTGACAACAATCTCCCTGCTACTTC
TTGCATCCTTCACATCCCTGTCTTGTGTGTGGTACTTCATGTTTTCTTGCCAAGACTGTGTTGATCTTCAGATACTCTCTTTGCCAGATG
AAGTTACTTGCTAACTCCAGAAATTCCTGCAGACATCCTACTCGGCCAGCGGTTTACCTGATAGATTCGGTAATACTATCAAGAGAAGAG
CCTAGGAGCACAGCGAGGGAATGAACCTTACTTGCACTTTATGTATACTTCCTGATTTGAAAGGAGGAGGTTTGAAAAGAAAAAAATGGA
GGTGGTAGATGCCACAGAGAGGCATCACGGAAGCCTTAACAGCAGGAAACAGAGAAATTTGTGTCATCTGAACAATTTCCAGATGTTCTT

>3350_3350_6_AKAP6-EGLN3_AKAP6_chr14_32903023_ENST00000557354_EGLN3_chr14_34400421_ENST00000553215_length(amino acids)=228AA_BP=108
MLTMSVTLSPLRSQDLDPMATDASPMAINMTPTVEQGEGEEAMKDMDSDQQYEKPPPLHTGADWKIVLHLPEIETWLRMTSERVRDLTYS
VQQDSDSKHVDVHLVQLKAMVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKLHGGILRIFPEGKSFIADVEPIFDRLLFFWSD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AKAP6-EGLN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AKAP6-EGLN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AKAP6-EGLN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource