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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GMPR2-MVP (FusionGDB2 ID:33504)

Fusion Gene Summary for GMPR2-MVP

check button Fusion gene summary
Fusion gene informationFusion gene name: GMPR2-MVP
Fusion gene ID: 33504
HgeneTgene
Gene symbol

GMPR2

MVP

Gene ID

51292

9961

Gene nameguanosine monophosphate reductase 2major vault protein
SynonymsGMPR 2LRP|VAULT1
Cytomap

14q12

16p11.2

Type of geneprotein-codingprotein-coding
DescriptionGMP reductase 2guanosine 5'-monophosphate oxidoreductase 2guanosine monophosphate reductase isologmajor vault proteinlung resistance-related proteintesticular secretory protein Li 30
Modification date2020031320200313
UniProtAcc.

Q14764

Ensembl transtripts involved in fusion geneENST00000348719, ENST00000355299, 
ENST00000399440, ENST00000420554, 
ENST00000456667, ENST00000557854, 
ENST00000559104, ENST00000559836, 
ENST00000559910, ENST00000560517, 
ENST00000357402, ENST00000395353, 
ENST00000452209, ENST00000566554, 
Fusion gene scores* DoF score4 X 4 X 4=6414 X 16 X 6=1344
# samples 416
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1344*10)=-3.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GMPR2 [Title/Abstract] AND MVP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGMPR2(24708257)-MVP(29855934), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGMPR2

GO:0046037

GMP metabolic process

22037469

TgeneMVP

GO:0023057

negative regulation of signaling

16441665

TgeneMVP

GO:0031953

negative regulation of protein autophosphorylation

16441665

TgeneMVP

GO:0038127

ERBB signaling pathway

15133037

TgeneMVP

GO:0061099

negative regulation of protein tyrosine kinase activity

16441665


check buttonFusion gene breakpoints across GMPR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MVP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315382GMPR2chr14

24708257

+MVPchr16

29855934

+


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Fusion Gene ORF analysis for GMPR2-MVP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000348719ENST00000357402GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-3CDSENST00000355299ENST00000357402GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-3CDSENST00000399440ENST00000357402GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-3CDSENST00000420554ENST00000357402GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-3CDSENST00000456667ENST00000357402GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-3CDSENST00000557854ENST00000357402GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-3CDSENST00000559104ENST00000357402GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-3CDSENST00000559836ENST00000357402GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-3CDSENST00000559910ENST00000357402GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-intronENST00000348719ENST00000395353GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-intronENST00000348719ENST00000452209GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-intronENST00000348719ENST00000566554GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-intronENST00000355299ENST00000395353GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-intronENST00000355299ENST00000452209GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-intronENST00000355299ENST00000566554GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-intronENST00000399440ENST00000395353GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-intronENST00000399440ENST00000452209GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-intronENST00000399440ENST00000566554GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-intronENST00000420554ENST00000395353GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-intronENST00000420554ENST00000452209GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-intronENST00000420554ENST00000566554GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-intronENST00000456667ENST00000395353GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-intronENST00000456667ENST00000452209GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-intronENST00000456667ENST00000566554GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-intronENST00000557854ENST00000395353GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-intronENST00000557854ENST00000452209GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-intronENST00000557854ENST00000566554GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-intronENST00000559104ENST00000395353GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-intronENST00000559104ENST00000452209GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-intronENST00000559104ENST00000566554GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-intronENST00000559836ENST00000395353GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-intronENST00000559836ENST00000452209GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-intronENST00000559836ENST00000566554GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-intronENST00000559910ENST00000395353GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-intronENST00000559910ENST00000452209GMPR2chr14

24708257

+MVPchr16

29855934

+
3UTR-intronENST00000559910ENST00000566554GMPR2chr14

24708257

+MVPchr16

29855934

+
intron-3CDSENST00000560517ENST00000357402GMPR2chr14

24708257

+MVPchr16

29855934

+
intron-intronENST00000560517ENST00000395353GMPR2chr14

24708257

+MVPchr16

29855934

+
intron-intronENST00000560517ENST00000452209GMPR2chr14

24708257

+MVPchr16

29855934

+
intron-intronENST00000560517ENST00000566554GMPR2chr14

24708257

+MVPchr16

29855934

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for GMPR2-MVP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GMPR2-MVP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:24708257/:29855934)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MVP

Q14764

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. {ECO:0000269|PubMed:15133037, ECO:0000269|PubMed:16418217, ECO:0000269|PubMed:16441665}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for GMPR2-MVP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GMPR2-MVP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GMPR2-MVP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GMPR2-MVP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource