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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GNA11-TLE6 (FusionGDB2 ID:33521)

Fusion Gene Summary for GNA11-TLE6

Fusion gene summary

Fusion gene information	Fusion gene name: GNA11-TLE6
	Fusion gene ID: 33521
		Hgene	Tgene
	Gene symbol	GNA11	TLE6
	Gene ID	2767	79816
	Gene name	G protein subunit alpha 11	TLE family member 6, subcortical maternal complex member
	Synonyms	FBH\|FBH2\|FHH2\|GNA-11\|HHC2\|HYPOC2	GRG6\|PREMBL
	Cytomap	19p13.3	19p13.3
	Type of gene	protein-coding	protein-coding
	Description	guanine nucleotide-binding protein subunit alpha-11g alpha-11guanine nucleotide binding protein (G protein), alpha 11 (Gq class)guanine nucleotide-binding protein G(y) subunit alpha	transducin-like enhancer protein 6transducin like enhancer of split 6transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)
	Modification date	20200313	20200313
	UniProtAcc	P29992	.
	Ensembl transtripts involved in fusion gene	ENST00000078429, ENST00000586180,	ENST00000452088, ENST00000478073, ENST00000482627, ENST00000246112,
Fusion gene scores	* DoF score	8 X 4 X 5=160	5 X 5 X 5=125
	# samples	12	7
	** MAII score	log2(12/160*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/125*10)=-0.836501267717121 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GNA11 [Title/Abstract] AND TLE6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GNA11(3113482)-TLE6(2991841), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across GNA11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TLE6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-8295-01A	GNA11	chr19	3113482	+	TLE6	chr19	2991841	+

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Fusion Gene ORF analysis for GNA11-TLE6

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000078429	ENST00000452088	GNA11	chr19	3113482	+	TLE6	chr19	2991841	+
5CDS-intron	ENST00000078429	ENST00000478073	GNA11	chr19	3113482	+	TLE6	chr19	2991841	+
5CDS-intron	ENST00000078429	ENST00000482627	GNA11	chr19	3113482	+	TLE6	chr19	2991841	+
In-frame	ENST00000078429	ENST00000246112	GNA11	chr19	3113482	+	TLE6	chr19	2991841	+
intron-3CDS	ENST00000586180	ENST00000246112	GNA11	chr19	3113482	+	TLE6	chr19	2991841	+
intron-intron	ENST00000586180	ENST00000452088	GNA11	chr19	3113482	+	TLE6	chr19	2991841	+
intron-intron	ENST00000586180	ENST00000478073	GNA11	chr19	3113482	+	TLE6	chr19	2991841	+
intron-intron	ENST00000586180	ENST00000482627	GNA11	chr19	3113482	+	TLE6	chr19	2991841	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000078429

GNA11

chr19

3113482

ENST00000246112

TLE6

chr19

2991841

1368

718

1180

393

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000078429	ENST00000246112	GNA11	chr19	3113482	+	TLE6	chr19	2991841	+	0.00279162	0.9972084

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Fusion Genomic Features for GNA11-TLE6

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
GNA11	chr19	3113482	+	TLE6	chr19	2991840	+	3.08E-06	0.9999969
GNA11	chr19	3113482	+	TLE6	chr19	2991840	+	3.08E-06	0.9999969

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GNA11-TLE6

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:3113482/chr19:2991841)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GNA11 P29992	.
FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C. Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs). {ECO:0000269\|PubMed:27852822}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GNA11

chr19:3113482

chr19:2991841

ENST00000078429

46_53

158

360.0

Nucleotide binding

GTP

Hgene

GNA11

chr19:3113482

chr19:2991841

ENST00000078429

41_54

158

360.0

Region

G1 motif

Tgene

TLE6

chr19:3113482

chr19:2991841

ENST00000246112

419_456

414

573.0

Repeat

Note=WD 4

Tgene

TLE6

chr19:3113482

chr19:2991841

ENST00000246112

458_497

414

573.0

Repeat

Note=WD 5

Tgene

TLE6

chr19:3113482

chr19:2991841

ENST00000246112

499_538

414

573.0

Repeat

Note=WD 6

Tgene

TLE6

chr19:3113482

chr19:2991841

ENST00000246112

540_571

414

573.0

Repeat

Note=WD 7

Tgene

TLE6

chr19:3113482

chr19:2991841

ENST00000452088

332_372

291

450.0

Repeat

Note=WD 2

Tgene

TLE6

chr19:3113482

chr19:2991841

ENST00000452088

377_416

291

450.0

Repeat

Note=WD 3

Tgene

TLE6

chr19:3113482

chr19:2991841

ENST00000452088

419_456

291

450.0

Repeat

Note=WD 4

Tgene

TLE6

chr19:3113482

chr19:2991841

ENST00000452088

458_497

291

450.0

Repeat

Note=WD 5

Tgene

TLE6

chr19:3113482

chr19:2991841

ENST00000452088

499_538

291

450.0

Repeat

Note=WD 6

Tgene

TLE6

chr19:3113482

chr19:2991841

ENST00000452088

540_571

291

450.0

Repeat

Note=WD 7

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GNA11

chr19:3113482

chr19:2991841

ENST00000078429

38_359

158

360.0

Domain

G-alpha

Hgene

GNA11

chr19:3113482

chr19:2991841

ENST00000078429

180_186

158

360.0

Nucleotide binding

GTP

Hgene

GNA11

chr19:3113482

chr19:2991841

ENST00000078429

205_209

158

360.0

Nucleotide binding

GTP

Hgene

GNA11

chr19:3113482

chr19:2991841

ENST00000078429

274_277

158

360.0

Nucleotide binding

GTP

Hgene

GNA11

chr19:3113482

chr19:2991841

ENST00000078429

178_186

158

360.0

Region

G2 motif

Hgene

GNA11

chr19:3113482

chr19:2991841

ENST00000078429

201_210

158

360.0

Region

G3 motif

Hgene

GNA11

chr19:3113482

chr19:2991841

ENST00000078429

270_277

158

360.0

Region

G4 motif

Hgene

GNA11

chr19:3113482

chr19:2991841

ENST00000078429

329_334

158

360.0

Region

G5 motif

Tgene

TLE6

chr19:3113482

chr19:2991841

ENST00000246112

284_322

414

573.0

Repeat

Note=WD 1

Tgene

TLE6

chr19:3113482

chr19:2991841

ENST00000246112

332_372

414

573.0

Repeat

Note=WD 2

Tgene

TLE6

chr19:3113482

chr19:2991841

ENST00000246112

377_416

414

573.0

Repeat

Note=WD 3

Tgene

TLE6

chr19:3113482

chr19:2991841

ENST00000452088

284_322

291

450.0

Repeat

Note=WD 1

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Fusion Gene Sequence for GNA11-TLE6

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>33521_33521_1_GNA11-TLE6_GNA11_chr19_3113482_ENST00000078429_TLE6_chr19_2991841_ENST00000246112_length(transcript)=1368nt_BP=718nt
GCTGCGGCGGCGGCGCGGGCTGAGTGCGGCCGCGCGGGAGTCCGCGGCTGGCGCGGCCCGAGCGGGGACCCGGCGGCTCGCCAGGCGGCG
GCCGAGGCGGGGCGGGCCGGCCCGGGGCCGAGGGCCGGTGGCCGAGGCCGGAGGGCCGCGGCGGGCGGCGGCCGAGGCGGCTCCGGCCAG
GGCCGGGCCGGGGGCCGGGGGGCGGCGGCGGGCAGGCGGCCGCGTCGGCCGGGGCCGGGACGATGACTCTGGAGTCCATGATGGCGTGTT
GCCTGAGCGATGAGGTGAAGGAGTCCAAGCGGATCAACGCCGAGATCGAGAAGCAGCTGCGGCGGGACAAGCGCGACGCCCGGCGCGAGC
TCAAGCTGCTGCTGCTCGGCACGGGCGAGAGCGGGAAGAGCACGTTCATCAAGCAGATGCGCATCATCCACGGCGCCGGCTACTCGGAGG
AGGACAAGCGCGGCTTCACCAAGCTCGTCTACCAGAACATCTTCACCGCCATGCAGGCCATGATCCGGGCCATGGAGACGCTCAAGATCC
TCTACAAGTACGAGCAGAACAAGGCCAATGCGCTCCTGATCCGGGAGGTGGACGTGGAGAAGGTGACCACCTTCGAGCATCAGTACGTCA
GTGCCATCAAGACCCTGTGGGAGGACCCGGGCATCCAGGAATGCTACGACCGCAGGCGCGAGTACCAGCTCTCCGACTCTGCCAAGTAGG
ACCTCAAGGGTTATCCTGATGGAGTCAAGAGTATCGTGGTCAAGGGCTACAACATCTGGACTGGGGGTCCGGATGCCTGTCTGCGGTGCT
GGGACCAGAGGACCATCATGAAACCTCTGGAGTACCAATTCAAGTCTCAGATAATGAGCCTGTCCCACAGCCCCCAGGAGGACTGGGTGC
TGCTGGGCATGGCCAATGGCCAGCAGTGGCTGCAAAGCACCAGCGGGAGCCAGCGGCACATGGTGGGGCAAAAAGACAGCGTCATCCTGA
GCGTCAAGTTCTCCCCCTTTGGCCAGTGGTGGGCAAGCGTTGGAATGGACGACTTCCTTGGCGTCTACAGCATGCCGGCGGGGACAAAAG
TGTTCGAGGTGCCTGAGATGTCTCCAGTCACGTGCTGTGACGTCTCTTCCAACAACCGCCTCGTTGTCACAGGCTCCGGGGAGCACGCCT
CCGTGTACCAGATCACCTACTGAGGGGCCTCGCTGCTGTCATCCCACTCCGGCTCCTCTTTTCATCCCCCCCCTTCCCCCCCCCCAACAA
GGGGGACATGGTGGAGGGAAGCGGGAAGGCTCTTCTGTGGCATCGCACGATCTAGTCTGTGGTGTAGACTGGTCGCCATCACGTGTAATA

>33521_33521_1_GNA11-TLE6_GNA11_chr19_3113482_ENST00000078429_TLE6_chr19_2991841_ENST00000246112_length(amino acids)=393AA_BP=218
MVHGGVLPGACDNEAVVGRDVTARDWRHLRHLEHFCPRRHAVDAKEVVHSNACPPLAKGGELDAQDDAVFLPHHVPLAPAGALQPLLAIG
HAQQHPVLLGAVGQAHYLRLELVLQRFHDGPLVPAPQTGIRTPSPDVVALDHDTLDSIRITLEVLLGRVGELVLAPAVVAFLDARVLPQG
LDGTDVLMLEGGHLLHVHLPDQERIGLVLLVLVEDLERLHGPDHGLHGGEDVLVDELGEAALVLLRVAGAVDDAHLLDERALPALARAEQ
QQLELAPGVALVPPQLLLDLGVDPLGLLHLIAQATRHHGLQSHRPGPGRRGRLPAAAPRPPARPWPEPPRPPPAAALRPRPPALGPGPAR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GNA11-TLE6

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for GNA11-TLE6

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for GNA11-TLE6

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source