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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GNA12-ADSS (FusionGDB2 ID:33523)

Fusion Gene Summary for GNA12-ADSS

check button Fusion gene summary
Fusion gene informationFusion gene name: GNA12-ADSS
Fusion gene ID: 33523
HgeneTgene
Gene symbol

GNA12

ADSS

Gene ID

2768

159

Gene nameG protein subunit alpha 12adenylosuccinate synthase 2
SynonymsNNX3|RMP|gepADEH|ADSS|ADSS 2
Cytomap

7p22.3-p22.2

1q44

Type of geneprotein-codingprotein-coding
Descriptionguanine nucleotide-binding protein subunit alpha-12WUGSC:H_GS165O14.2g alpha-12guanine nucleotide binding protein (G protein) alpha 12adenylosuccinate synthetase isozyme 2AMPSase 2IMP--aspartate ligase 2L-type adenylosuccinate synthetaseadSS 2adenylosuccinate synthetase (Ade(-)H-complementing)adenylosuccinate synthetase, acidic isozymeadenylosuccinate synthetase, liver isozymeep
Modification date2020031320200313
UniProtAcc.

P30520

Ensembl transtripts involved in fusion geneENST00000275364, ENST00000407904, 
ENST00000544127, ENST00000396960, 
ENST00000407653, ENST00000491117, 
ENST00000462358, ENST00000366535, 
Fusion gene scores* DoF score11 X 4 X 7=30810 X 5 X 6=300
# samples 1412
** MAII scorelog2(14/308*10)=-1.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/300*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GNA12 [Title/Abstract] AND ADSS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGNA12(2834562)-ADSS(244601070), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneADSS

GO:0006167

AMP biosynthetic process

2004783


check buttonFusion gene breakpoints across GNA12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ADSS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E9-A1N6-01AGNA12chr7

2834562

-ADSSchr1

244601070

-
ChimerDB4BRCATCGA-E9-A1N6GNA12chr7

2834561

-ADSSchr1

244601070

-


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Fusion Gene ORF analysis for GNA12-ADSS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000275364ENST00000462358GNA12chr7

2834562

-ADSSchr1

244601070

-
5CDS-intronENST00000275364ENST00000462358GNA12chr7

2834561

-ADSSchr1

244601070

-
5CDS-intronENST00000407904ENST00000462358GNA12chr7

2834562

-ADSSchr1

244601070

-
5CDS-intronENST00000407904ENST00000462358GNA12chr7

2834561

-ADSSchr1

244601070

-
5CDS-intronENST00000544127ENST00000462358GNA12chr7

2834562

-ADSSchr1

244601070

-
5CDS-intronENST00000544127ENST00000462358GNA12chr7

2834561

-ADSSchr1

244601070

-
In-frameENST00000275364ENST00000366535GNA12chr7

2834562

-ADSSchr1

244601070

-
In-frameENST00000275364ENST00000366535GNA12chr7

2834561

-ADSSchr1

244601070

-
In-frameENST00000407904ENST00000366535GNA12chr7

2834562

-ADSSchr1

244601070

-
In-frameENST00000407904ENST00000366535GNA12chr7

2834561

-ADSSchr1

244601070

-
In-frameENST00000544127ENST00000366535GNA12chr7

2834562

-ADSSchr1

244601070

-
In-frameENST00000544127ENST00000366535GNA12chr7

2834561

-ADSSchr1

244601070

-
intron-3CDSENST00000396960ENST00000366535GNA12chr7

2834562

-ADSSchr1

244601070

-
intron-3CDSENST00000396960ENST00000366535GNA12chr7

2834561

-ADSSchr1

244601070

-
intron-3CDSENST00000407653ENST00000366535GNA12chr7

2834562

-ADSSchr1

244601070

-
intron-3CDSENST00000407653ENST00000366535GNA12chr7

2834561

-ADSSchr1

244601070

-
intron-3CDSENST00000491117ENST00000366535GNA12chr7

2834562

-ADSSchr1

244601070

-
intron-3CDSENST00000491117ENST00000366535GNA12chr7

2834561

-ADSSchr1

244601070

-
intron-intronENST00000396960ENST00000462358GNA12chr7

2834562

-ADSSchr1

244601070

-
intron-intronENST00000396960ENST00000462358GNA12chr7

2834561

-ADSSchr1

244601070

-
intron-intronENST00000407653ENST00000462358GNA12chr7

2834562

-ADSSchr1

244601070

-
intron-intronENST00000407653ENST00000462358GNA12chr7

2834561

-ADSSchr1

244601070

-
intron-intronENST00000491117ENST00000462358GNA12chr7

2834562

-ADSSchr1

244601070

-
intron-intronENST00000491117ENST00000462358GNA12chr7

2834561

-ADSSchr1

244601070

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000275364GNA12chr72834562-ENST00000366535ADSSchr1244601070-29686881631875570
ENST00000544127GNA12chr72834562-ENST00000366535ADSSchr1244601070-2660380231567514
ENST00000407904GNA12chr72834562-ENST00000366535ADSSchr1244601070-29576773291864511
ENST00000275364GNA12chr72834561-ENST00000366535ADSSchr1244601070-29686881631875570
ENST00000544127GNA12chr72834561-ENST00000366535ADSSchr1244601070-2660380231567514
ENST00000407904GNA12chr72834561-ENST00000366535ADSSchr1244601070-29576773291864511

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000275364ENST00000366535GNA12chr72834562-ADSSchr1244601070-0.000347040.999653
ENST00000544127ENST00000366535GNA12chr72834562-ADSSchr1244601070-0.0001131640.9998869
ENST00000407904ENST00000366535GNA12chr72834562-ADSSchr1244601070-0.0002884140.9997116
ENST00000275364ENST00000366535GNA12chr72834561-ADSSchr1244601070-0.000347040.999653
ENST00000544127ENST00000366535GNA12chr72834561-ADSSchr1244601070-0.0001131640.9998869
ENST00000407904ENST00000366535GNA12chr72834561-ADSSchr1244601070-0.0002884140.9997116

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Fusion Genomic Features for GNA12-ADSS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GNA12-ADSS


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:2834562/chr1:244601070)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ADSS

P30520

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. {ECO:0000250|UniProtKB:P46664}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGNA12chr7:2834561chr1:244601070ENST00000275364-2467_72175382.0Nucleotide bindingGTP
HgeneGNA12chr7:2834562chr1:244601070ENST00000275364-2467_72175382.0Nucleotide bindingGTP
HgeneGNA12chr7:2834561chr1:244601070ENST00000275364-2459_72175382.0RegionG1 motif
HgeneGNA12chr7:2834562chr1:244601070ENST00000275364-2459_72175382.0RegionG1 motif
TgeneADSSchr7:2834561chr1:244601070ENST00000366535013362_36461457.0Nucleotide bindingNote=GTP
TgeneADSSchr7:2834561chr1:244601070ENST00000366535013444_44761457.0Nucleotide bindingNote=GTP
TgeneADSSchr7:2834561chr1:244601070ENST0000036653501367_6961457.0Nucleotide bindingNote=GTP
TgeneADSSchr7:2834562chr1:244601070ENST00000366535013362_36461457.0Nucleotide bindingNote=GTP
TgeneADSSchr7:2834562chr1:244601070ENST00000366535013444_44761457.0Nucleotide bindingNote=GTP
TgeneADSSchr7:2834562chr1:244601070ENST0000036653501367_6961457.0Nucleotide bindingNote=GTP
TgeneADSSchr7:2834561chr1:244601070ENST00000366535013330_33661457.0RegionSubstrate binding
TgeneADSSchr7:2834561chr1:244601070ENST0000036653501365_6861457.0RegionIMP binding
TgeneADSSchr7:2834562chr1:244601070ENST00000366535013330_33661457.0RegionSubstrate binding
TgeneADSSchr7:2834562chr1:244601070ENST0000036653501365_6861457.0RegionIMP binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGNA12chr7:2834561chr1:244601070ENST00000275364-2456_381175382.0DomainG-alpha
HgeneGNA12chr7:2834562chr1:244601070ENST00000275364-2456_381175382.0DomainG-alpha
HgeneGNA12chr7:2834561chr1:244601070ENST00000275364-24202_205175382.0Nucleotide bindingGTP
HgeneGNA12chr7:2834561chr1:244601070ENST00000275364-24296_299175382.0Nucleotide bindingGTP
HgeneGNA12chr7:2834562chr1:244601070ENST00000275364-24202_205175382.0Nucleotide bindingGTP
HgeneGNA12chr7:2834562chr1:244601070ENST00000275364-24296_299175382.0Nucleotide bindingGTP
HgeneGNA12chr7:2834561chr1:244601070ENST00000275364-24200_208175382.0RegionG2 motif
HgeneGNA12chr7:2834561chr1:244601070ENST00000275364-24223_232175382.0RegionG3 motif
HgeneGNA12chr7:2834561chr1:244601070ENST00000275364-24292_299175382.0RegionG4 motif
HgeneGNA12chr7:2834561chr1:244601070ENST00000275364-24351_356175382.0RegionG5 motif
HgeneGNA12chr7:2834562chr1:244601070ENST00000275364-24200_208175382.0RegionG2 motif
HgeneGNA12chr7:2834562chr1:244601070ENST00000275364-24223_232175382.0RegionG3 motif
HgeneGNA12chr7:2834562chr1:244601070ENST00000275364-24292_299175382.0RegionG4 motif
HgeneGNA12chr7:2834562chr1:244601070ENST00000275364-24351_356175382.0RegionG5 motif
TgeneADSSchr7:2834561chr1:244601070ENST0000036653501339_4561457.0Nucleotide bindingNote=GTP
TgeneADSSchr7:2834562chr1:244601070ENST0000036653501339_4561457.0Nucleotide bindingNote=GTP
TgeneADSSchr7:2834561chr1:244601070ENST0000036653501340_4361457.0RegionIMP binding
TgeneADSSchr7:2834562chr1:244601070ENST0000036653501340_4361457.0RegionIMP binding


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Fusion Gene Sequence for GNA12-ADSS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>33523_33523_1_GNA12-ADSS_GNA12_chr7_2834561_ENST00000275364_ADSS_chr1_244601070_ENST00000366535_length(transcript)=2968nt_BP=688nt
GGCGACGAGTGCGGGCCTCGGAGCGACTGCAGCGGCGGCGGCGGACGCGGCCTGAGGCGAGCGGCGGGGCGTGGGGCGGTGCCTCGGCCC
GGGCTCGCCCTCGCCGGCGGGAGCGTCCATGGCCCCCGGGCGCCGGCGGGGCGCGGCCGCGGCCTGAGGGGCCATGTCCGGGGTGGTGCG
GACCCTCAGCCGCTGCCTGCTGCCGGCCGAGGCCGGCGGGGCCCGCGAGCGCAGGGCGGGCAGCGGCGCGCGCGACGCGGAGCGCGAGGC
CCGGAGGCGTAGCCGCGACATCGACGCGCTGCTGGCCCGCGAGCGGCGCGCGGTCCGGCGCCTGGTGAAGATCCTGCTGCTGGGCGCGGG
CGAGAGCGGCAAGTCCACGTTCCTCAAGCAGATGCGCATCATCCACGGCCGCGAGTTCGACCAGAAGGCGCTGCTGGAGTTCCGCGACAC
CATCTTCGACAACATCCTCAAGGGCTCAAGGGTTCTTGTTGATGCACGAGATAAGCTTGGCATTCCTTGGCAGTATTCTGAAAATGAGAA
GCATGGGATGTTCCTGATGGCCTTCGAGAACAAGGCGGGGCTGCCTGTGGAGCCGGCCACCTTCCAGCTGTACGTCCCGGCCCTGAGCGC
ACTCTGGAGGGATTCTGGCATCAGGGAGGCTTTCAGCCGGAGAAGCGAGTTTCAGCTGGGAGGAAATAATGCTGGCCATACAGTTGTTGT
GGATTCTGTGGAATATGATTTTCATCTCTTACCCAGTGGAATAATTAATCCAAATGTCACTGCATTCATTGGAAATGGTGTGGTAATTCA
TCTACCTGGATTGTTTGAAGAAGCAGAGAAAAATGTTCAAAAAGGAAAAGGACTAGAAGGCTGGGAAAAAAGGCTTATTATATCTGACAG
AGCTCATATTGTATTTGATTTTCATCAAGCAGCTGATGGTATCCAGGAACAACAGAGACAAGAACAAGCAGGAAAAAATTTGGGTACAAC
AAAAAAGGGCATTGGCCCAGTTTATTCGTCCAAAGCTGCTCGGAGTGGACTCAGGATGTGCGACCTTGTTTCTGACTTTGATGGCTTCTC
TGAGAGGTTTAAAGTTCTAGCTAACCAATACAAATCTATATACCCCACTTTGGAAATAGACATTGAAGGTGAATTACAAAAACTCAAGGG
TTATATGGAAAAGATTAAACCAATGGTGAGAGATGGAGTTTATTTTCTATATGAGGCCCTACATGGACCACCAAAGAAAATCTTGGTAGA
AGGTGCAAATGCAGCACTATTAGATATTGATTTTGGGACTTACCCTTTTGTAACCTCTTCAAATTGTACTGTTGGAGGTGTTTGTACTGG
TTTGGGTATGCCACCTCAAAATGTTGGAGAAGTGTATGGAGTTGTGAAAGCTTATACAACTAGAGTTGGTATTGGTGCCTTTCCTACAGA
GCAAGACAATGAAATTGGAGAATTATTACAAACAAGGGGTAGAGAGTTTGGTGTAACTACTGGAAGGAAAAGAAGATGTGGCTGGTTGGA
CCTCGTTTTGCTCAAATATGCTCATATGATCAATGGATTTACTGCGTTGGCACTTACCAAGTTGGATATTTTGGACATGTTTACGGAAAT
CAAAGTTGGAGTTGCTTACAAGTTAGATGGTGAAATCATACCTCATATCCCAGCAAACCAAGAAGTCTTAAATAAAGTTGAAGTTCAATA
TAAGACTCTCCCAGGATGGAACACAGACATATCAAATGCAAGGGCGTTTAAAGAACTACCTGTTAATGCACAAAACTATGTTCGATTTAT
TGAAGATGAGCTTCAAATTCCAGTTAAGTGGATTGGTGTTGGTAAATCCAGAGAATCTATGATTCAACTCTTTTAATGATTGCCAGTAAT
GCAAGAAACACTCCTTGAGAGGGAGGGGAAAAGACTTTCTTAAATATTTCATTTATGACCTGCAAATTCAAGAATAAAGACACTGAAGTA
AGTTTGAAGCCCTACAGTTGTTTCCAGTCTTTTCAGATGGATGCCTACTGTGGAGATTAACTTTGGCATATTCCAGTGTCAGCTTTCTTT
AGCTGGAATTGCCAAATCATTTGTTGCTCCTGCTGCTCTCATGGTGCCACGTTTTTTTTTTCAATGTTTAGTAATAGTATAATCCATGTT
GTTTGATATCAAAAGTAGAATTACTTTTAATGTAGTTTTTCTTCATTATTGTCATTGCGTGTTCTTAAGTTTTACCCCTATTAGATGGTA
AGAACAATTAATGCAGTTTTGCACAAATATTTTTACATTCTGATCATTCAGTTCTGTCATTGTAATCTTTGTTGTTAGAAACAAATGATG
AAAACATAGGGGTTCTGTAAACTTTTGTAATGCTATGAATTCTGTTTAAATTTTGGGCTGTCTATTTTCTGCTGAAACCATGCAAAATTG
AGCTTTGGTGGGGCTGGGAGGGGGTTATGTATTCATGGGACCTTTAATTTGTACAGAACACAGAACTTATTTCTGTCAGTTATTTAATAC
ATTGAAAATTTAGTGAAATGTTCAAAGAGAATAGATGTTTCCCAAAACAACAATCTTTATGTTAAAAATAGTCATTAAAAGATCTGTTGT
AATATATGGTGGATATTTTTCTTTAATTTCAAACATTACCTCTGAAATGTGTATCTTTTCTTTTTTATCTTACCATTAATTTTAAATCTA
GTGGATTGGTTTTCAACATCGTGCCTGCCGATATGCCTACAGAATCATCTGTAAGTGTCAAAATGAACCCACGTTGTTAGCCATAATTTT
GATTATGCCTTTATTTCTCCTTTCTTGAAAAAAAAAAGGTGTTATTTTGACAATTAGGCATAACATTGTTTTGTAGATTATCTTTTAATG

>33523_33523_1_GNA12-ADSS_GNA12_chr7_2834561_ENST00000275364_ADSS_chr1_244601070_ENST00000366535_length(amino acids)=570AA_BP=175
MSGVVRTLSRCLLPAEAGGARERRAGSGARDAEREARRRSRDIDALLARERRAVRRLVKILLLGAGESGKSTFLKQMRIIHGREFDQKAL
LEFRDTIFDNILKGSRVLVDARDKLGIPWQYSENEKHGMFLMAFENKAGLPVEPATFQLYVPALSALWRDSGIREAFSRRSEFQLGGNNA
GHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAEKNVQKGKGLEGWEKRLIISDRAHIVFDFHQAADGIQEQQRQEQAG
KNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDGFSERFKVLANQYKSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHGPP
KKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKR
RCGWLDLVLLKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIPANQEVLNKVEVQYKTLPGWNTDISNARAFKELPVNAQ

--------------------------------------------------------------
>33523_33523_2_GNA12-ADSS_GNA12_chr7_2834561_ENST00000407904_ADSS_chr1_244601070_ENST00000366535_length(transcript)=2957nt_BP=677nt
ATTTAAGCAGCCTCCTTGACTGTAGGTCCGCTGACTGGCTTCCTCCTTGAGAGCACACTCACAGTGCCGGACCGCAGGCACCTCGCCGAT
GTTCCTGTCCACTTGCTTTTTGTATTGCTCCTTCTCCAGTGAGCTTGGAAGCCTCATGCGGGCAAGGCCTTGTCTGTCTGGTTCTCTGTT
GTGTCCTCGGAGCCTGCCACAGTGGCGGCGCTTGGTGGCTTTGACAGGGGACTGGATTGGGTGGAAGGGGCGAGATTAGACCTGGATACA
GTGACGTCCTTGTCAGCCATGCCGAGTGCAGAGCGCCTACTGTATTGTAGGCATTTGAAATGAAACGGAGAATGTTTCCCAGGCCGTGCC
TAGCAAGGATGCCTGGCAGTCGTGGTTCGGGAAGCACACCAGATGGAAACCGAAAGTGCTGCCGTTTTGAGCACCTACTCATTGCACACC
CTGGGTCCAGGGGCTCAAGGGTTCTTGTTGATGCACGAGATAAGCTTGGCATTCCTTGGCAGTATTCTGAAAATGAGAAGCATGGGATGT
TCCTGATGGCCTTCGAGAACAAGGCGGGGCTGCCTGTGGAGCCGGCCACCTTCCAGCTGTACGTCCCGGCCCTGAGCGCACTCTGGAGGG
ATTCTGGCATCAGGGAGGCTTTCAGCCGGAGAAGCGAGTTTCAGCTGGGAGGAAATAATGCTGGCCATACAGTTGTTGTGGATTCTGTGG
AATATGATTTTCATCTCTTACCCAGTGGAATAATTAATCCAAATGTCACTGCATTCATTGGAAATGGTGTGGTAATTCATCTACCTGGAT
TGTTTGAAGAAGCAGAGAAAAATGTTCAAAAAGGAAAAGGACTAGAAGGCTGGGAAAAAAGGCTTATTATATCTGACAGAGCTCATATTG
TATTTGATTTTCATCAAGCAGCTGATGGTATCCAGGAACAACAGAGACAAGAACAAGCAGGAAAAAATTTGGGTACAACAAAAAAGGGCA
TTGGCCCAGTTTATTCGTCCAAAGCTGCTCGGAGTGGACTCAGGATGTGCGACCTTGTTTCTGACTTTGATGGCTTCTCTGAGAGGTTTA
AAGTTCTAGCTAACCAATACAAATCTATATACCCCACTTTGGAAATAGACATTGAAGGTGAATTACAAAAACTCAAGGGTTATATGGAAA
AGATTAAACCAATGGTGAGAGATGGAGTTTATTTTCTATATGAGGCCCTACATGGACCACCAAAGAAAATCTTGGTAGAAGGTGCAAATG
CAGCACTATTAGATATTGATTTTGGGACTTACCCTTTTGTAACCTCTTCAAATTGTACTGTTGGAGGTGTTTGTACTGGTTTGGGTATGC
CACCTCAAAATGTTGGAGAAGTGTATGGAGTTGTGAAAGCTTATACAACTAGAGTTGGTATTGGTGCCTTTCCTACAGAGCAAGACAATG
AAATTGGAGAATTATTACAAACAAGGGGTAGAGAGTTTGGTGTAACTACTGGAAGGAAAAGAAGATGTGGCTGGTTGGACCTCGTTTTGC
TCAAATATGCTCATATGATCAATGGATTTACTGCGTTGGCACTTACCAAGTTGGATATTTTGGACATGTTTACGGAAATCAAAGTTGGAG
TTGCTTACAAGTTAGATGGTGAAATCATACCTCATATCCCAGCAAACCAAGAAGTCTTAAATAAAGTTGAAGTTCAATATAAGACTCTCC
CAGGATGGAACACAGACATATCAAATGCAAGGGCGTTTAAAGAACTACCTGTTAATGCACAAAACTATGTTCGATTTATTGAAGATGAGC
TTCAAATTCCAGTTAAGTGGATTGGTGTTGGTAAATCCAGAGAATCTATGATTCAACTCTTTTAATGATTGCCAGTAATGCAAGAAACAC
TCCTTGAGAGGGAGGGGAAAAGACTTTCTTAAATATTTCATTTATGACCTGCAAATTCAAGAATAAAGACACTGAAGTAAGTTTGAAGCC
CTACAGTTGTTTCCAGTCTTTTCAGATGGATGCCTACTGTGGAGATTAACTTTGGCATATTCCAGTGTCAGCTTTCTTTAGCTGGAATTG
CCAAATCATTTGTTGCTCCTGCTGCTCTCATGGTGCCACGTTTTTTTTTTCAATGTTTAGTAATAGTATAATCCATGTTGTTTGATATCA
AAAGTAGAATTACTTTTAATGTAGTTTTTCTTCATTATTGTCATTGCGTGTTCTTAAGTTTTACCCCTATTAGATGGTAAGAACAATTAA
TGCAGTTTTGCACAAATATTTTTACATTCTGATCATTCAGTTCTGTCATTGTAATCTTTGTTGTTAGAAACAAATGATGAAAACATAGGG
GTTCTGTAAACTTTTGTAATGCTATGAATTCTGTTTAAATTTTGGGCTGTCTATTTTCTGCTGAAACCATGCAAAATTGAGCTTTGGTGG
GGCTGGGAGGGGGTTATGTATTCATGGGACCTTTAATTTGTACAGAACACAGAACTTATTTCTGTCAGTTATTTAATACATTGAAAATTT
AGTGAAATGTTCAAAGAGAATAGATGTTTCCCAAAACAACAATCTTTATGTTAAAAATAGTCATTAAAAGATCTGTTGTAATATATGGTG
GATATTTTTCTTTAATTTCAAACATTACCTCTGAAATGTGTATCTTTTCTTTTTTATCTTACCATTAATTTTAAATCTAGTGGATTGGTT
TTCAACATCGTGCCTGCCGATATGCCTACAGAATCATCTGTAAGTGTCAAAATGAACCCACGTTGTTAGCCATAATTTTGATTATGCCTT
TATTTCTCCTTTCTTGAAAAAAAAAAGGTGTTATTTTGACAATTAGGCATAACATTGTTTTGTAGATTATCTTTTAATGAACTATTTTAA

>33523_33523_2_GNA12-ADSS_GNA12_chr7_2834561_ENST00000407904_ADSS_chr1_244601070_ENST00000366535_length(amino acids)=511AA_BP=116
MKRRMFPRPCLARMPGSRGSGSTPDGNRKCCRFEHLLIAHPGSRGSRVLVDARDKLGIPWQYSENEKHGMFLMAFENKAGLPVEPATFQL
YVPALSALWRDSGIREAFSRRSEFQLGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAEKNVQKGKGLEGWEK
RLIISDRAHIVFDFHQAADGIQEQQRQEQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDGFSERFKVLANQYKSIYPTLEIDIEG
ELQKLKGYMEKIKPMVRDGVYFLYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVG
IGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIPANQEVL

--------------------------------------------------------------
>33523_33523_3_GNA12-ADSS_GNA12_chr7_2834561_ENST00000544127_ADSS_chr1_244601070_ENST00000366535_length(transcript)=2660nt_BP=380nt
GCGAGCGGCGCGCGGTCCGGCGCCTGGTGAAGATCCTGCTGCTGGGCGCGGGCGAGAGCGGCAAGTCCACGTTCCTCAAGCAGATGCGCA
TCATCCACGGCCGCGAGTTCGACCAGAAGGCGCTGCTGGAGTTCCGCGACACCATCTTCGACAACATCCTCAAGGGCTCAAGGGTTCTTG
TTGATGCACGAGATAAGCTTGGCATTCCTTGGCAGTATTCTGAAAATGAGAAGCATGGGATGTTCCTGATGGCCTTCGAGAACAAGGCGG
GGCTGCCTGTGGAGCCGGCCACCTTCCAGCTGTACGTCCCGGCCCTGAGCGCACTCTGGAGGGATTCTGGCATCAGGGAGGCTTTCAGCC
GGAGAAGCGAGTTTCAGCTGGGAGGAAATAATGCTGGCCATACAGTTGTTGTGGATTCTGTGGAATATGATTTTCATCTCTTACCCAGTG
GAATAATTAATCCAAATGTCACTGCATTCATTGGAAATGGTGTGGTAATTCATCTACCTGGATTGTTTGAAGAAGCAGAGAAAAATGTTC
AAAAAGGAAAAGGACTAGAAGGCTGGGAAAAAAGGCTTATTATATCTGACAGAGCTCATATTGTATTTGATTTTCATCAAGCAGCTGATG
GTATCCAGGAACAACAGAGACAAGAACAAGCAGGAAAAAATTTGGGTACAACAAAAAAGGGCATTGGCCCAGTTTATTCGTCCAAAGCTG
CTCGGAGTGGACTCAGGATGTGCGACCTTGTTTCTGACTTTGATGGCTTCTCTGAGAGGTTTAAAGTTCTAGCTAACCAATACAAATCTA
TATACCCCACTTTGGAAATAGACATTGAAGGTGAATTACAAAAACTCAAGGGTTATATGGAAAAGATTAAACCAATGGTGAGAGATGGAG
TTTATTTTCTATATGAGGCCCTACATGGACCACCAAAGAAAATCTTGGTAGAAGGTGCAAATGCAGCACTATTAGATATTGATTTTGGGA
CTTACCCTTTTGTAACCTCTTCAAATTGTACTGTTGGAGGTGTTTGTACTGGTTTGGGTATGCCACCTCAAAATGTTGGAGAAGTGTATG
GAGTTGTGAAAGCTTATACAACTAGAGTTGGTATTGGTGCCTTTCCTACAGAGCAAGACAATGAAATTGGAGAATTATTACAAACAAGGG
GTAGAGAGTTTGGTGTAACTACTGGAAGGAAAAGAAGATGTGGCTGGTTGGACCTCGTTTTGCTCAAATATGCTCATATGATCAATGGAT
TTACTGCGTTGGCACTTACCAAGTTGGATATTTTGGACATGTTTACGGAAATCAAAGTTGGAGTTGCTTACAAGTTAGATGGTGAAATCA
TACCTCATATCCCAGCAAACCAAGAAGTCTTAAATAAAGTTGAAGTTCAATATAAGACTCTCCCAGGATGGAACACAGACATATCAAATG
CAAGGGCGTTTAAAGAACTACCTGTTAATGCACAAAACTATGTTCGATTTATTGAAGATGAGCTTCAAATTCCAGTTAAGTGGATTGGTG
TTGGTAAATCCAGAGAATCTATGATTCAACTCTTTTAATGATTGCCAGTAATGCAAGAAACACTCCTTGAGAGGGAGGGGAAAAGACTTT
CTTAAATATTTCATTTATGACCTGCAAATTCAAGAATAAAGACACTGAAGTAAGTTTGAAGCCCTACAGTTGTTTCCAGTCTTTTCAGAT
GGATGCCTACTGTGGAGATTAACTTTGGCATATTCCAGTGTCAGCTTTCTTTAGCTGGAATTGCCAAATCATTTGTTGCTCCTGCTGCTC
TCATGGTGCCACGTTTTTTTTTTCAATGTTTAGTAATAGTATAATCCATGTTGTTTGATATCAAAAGTAGAATTACTTTTAATGTAGTTT
TTCTTCATTATTGTCATTGCGTGTTCTTAAGTTTTACCCCTATTAGATGGTAAGAACAATTAATGCAGTTTTGCACAAATATTTTTACAT
TCTGATCATTCAGTTCTGTCATTGTAATCTTTGTTGTTAGAAACAAATGATGAAAACATAGGGGTTCTGTAAACTTTTGTAATGCTATGA
ATTCTGTTTAAATTTTGGGCTGTCTATTTTCTGCTGAAACCATGCAAAATTGAGCTTTGGTGGGGCTGGGAGGGGGTTATGTATTCATGG
GACCTTTAATTTGTACAGAACACAGAACTTATTTCTGTCAGTTATTTAATACATTGAAAATTTAGTGAAATGTTCAAAGAGAATAGATGT
TTCCCAAAACAACAATCTTTATGTTAAAAATAGTCATTAAAAGATCTGTTGTAATATATGGTGGATATTTTTCTTTAATTTCAAACATTA
CCTCTGAAATGTGTATCTTTTCTTTTTTATCTTACCATTAATTTTAAATCTAGTGGATTGGTTTTCAACATCGTGCCTGCCGATATGCCT
ACAGAATCATCTGTAAGTGTCAAAATGAACCCACGTTGTTAGCCATAATTTTGATTATGCCTTTATTTCTCCTTTCTTGAAAAAAAAAAG
GTGTTATTTTGACAATTAGGCATAACATTGTTTTGTAGATTATCTTTTAATGAACTATTTTAAATGTTAAATTAGGTGCCACTTAAATTT

>33523_33523_3_GNA12-ADSS_GNA12_chr7_2834561_ENST00000544127_ADSS_chr1_244601070_ENST00000366535_length(amino acids)=514AA_BP=119
MVKILLLGAGESGKSTFLKQMRIIHGREFDQKALLEFRDTIFDNILKGSRVLVDARDKLGIPWQYSENEKHGMFLMAFENKAGLPVEPAT
FQLYVPALSALWRDSGIREAFSRRSEFQLGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAEKNVQKGKGLEG
WEKRLIISDRAHIVFDFHQAADGIQEQQRQEQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDGFSERFKVLANQYKSIYPTLEID
IEGELQKLKGYMEKIKPMVRDGVYFLYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTT
RVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIPANQ

--------------------------------------------------------------
>33523_33523_4_GNA12-ADSS_GNA12_chr7_2834562_ENST00000275364_ADSS_chr1_244601070_ENST00000366535_length(transcript)=2968nt_BP=688nt
GGCGACGAGTGCGGGCCTCGGAGCGACTGCAGCGGCGGCGGCGGACGCGGCCTGAGGCGAGCGGCGGGGCGTGGGGCGGTGCCTCGGCCC
GGGCTCGCCCTCGCCGGCGGGAGCGTCCATGGCCCCCGGGCGCCGGCGGGGCGCGGCCGCGGCCTGAGGGGCCATGTCCGGGGTGGTGCG
GACCCTCAGCCGCTGCCTGCTGCCGGCCGAGGCCGGCGGGGCCCGCGAGCGCAGGGCGGGCAGCGGCGCGCGCGACGCGGAGCGCGAGGC
CCGGAGGCGTAGCCGCGACATCGACGCGCTGCTGGCCCGCGAGCGGCGCGCGGTCCGGCGCCTGGTGAAGATCCTGCTGCTGGGCGCGGG
CGAGAGCGGCAAGTCCACGTTCCTCAAGCAGATGCGCATCATCCACGGCCGCGAGTTCGACCAGAAGGCGCTGCTGGAGTTCCGCGACAC
CATCTTCGACAACATCCTCAAGGGCTCAAGGGTTCTTGTTGATGCACGAGATAAGCTTGGCATTCCTTGGCAGTATTCTGAAAATGAGAA
GCATGGGATGTTCCTGATGGCCTTCGAGAACAAGGCGGGGCTGCCTGTGGAGCCGGCCACCTTCCAGCTGTACGTCCCGGCCCTGAGCGC
ACTCTGGAGGGATTCTGGCATCAGGGAGGCTTTCAGCCGGAGAAGCGAGTTTCAGCTGGGAGGAAATAATGCTGGCCATACAGTTGTTGT
GGATTCTGTGGAATATGATTTTCATCTCTTACCCAGTGGAATAATTAATCCAAATGTCACTGCATTCATTGGAAATGGTGTGGTAATTCA
TCTACCTGGATTGTTTGAAGAAGCAGAGAAAAATGTTCAAAAAGGAAAAGGACTAGAAGGCTGGGAAAAAAGGCTTATTATATCTGACAG
AGCTCATATTGTATTTGATTTTCATCAAGCAGCTGATGGTATCCAGGAACAACAGAGACAAGAACAAGCAGGAAAAAATTTGGGTACAAC
AAAAAAGGGCATTGGCCCAGTTTATTCGTCCAAAGCTGCTCGGAGTGGACTCAGGATGTGCGACCTTGTTTCTGACTTTGATGGCTTCTC
TGAGAGGTTTAAAGTTCTAGCTAACCAATACAAATCTATATACCCCACTTTGGAAATAGACATTGAAGGTGAATTACAAAAACTCAAGGG
TTATATGGAAAAGATTAAACCAATGGTGAGAGATGGAGTTTATTTTCTATATGAGGCCCTACATGGACCACCAAAGAAAATCTTGGTAGA
AGGTGCAAATGCAGCACTATTAGATATTGATTTTGGGACTTACCCTTTTGTAACCTCTTCAAATTGTACTGTTGGAGGTGTTTGTACTGG
TTTGGGTATGCCACCTCAAAATGTTGGAGAAGTGTATGGAGTTGTGAAAGCTTATACAACTAGAGTTGGTATTGGTGCCTTTCCTACAGA
GCAAGACAATGAAATTGGAGAATTATTACAAACAAGGGGTAGAGAGTTTGGTGTAACTACTGGAAGGAAAAGAAGATGTGGCTGGTTGGA
CCTCGTTTTGCTCAAATATGCTCATATGATCAATGGATTTACTGCGTTGGCACTTACCAAGTTGGATATTTTGGACATGTTTACGGAAAT
CAAAGTTGGAGTTGCTTACAAGTTAGATGGTGAAATCATACCTCATATCCCAGCAAACCAAGAAGTCTTAAATAAAGTTGAAGTTCAATA
TAAGACTCTCCCAGGATGGAACACAGACATATCAAATGCAAGGGCGTTTAAAGAACTACCTGTTAATGCACAAAACTATGTTCGATTTAT
TGAAGATGAGCTTCAAATTCCAGTTAAGTGGATTGGTGTTGGTAAATCCAGAGAATCTATGATTCAACTCTTTTAATGATTGCCAGTAAT
GCAAGAAACACTCCTTGAGAGGGAGGGGAAAAGACTTTCTTAAATATTTCATTTATGACCTGCAAATTCAAGAATAAAGACACTGAAGTA
AGTTTGAAGCCCTACAGTTGTTTCCAGTCTTTTCAGATGGATGCCTACTGTGGAGATTAACTTTGGCATATTCCAGTGTCAGCTTTCTTT
AGCTGGAATTGCCAAATCATTTGTTGCTCCTGCTGCTCTCATGGTGCCACGTTTTTTTTTTCAATGTTTAGTAATAGTATAATCCATGTT
GTTTGATATCAAAAGTAGAATTACTTTTAATGTAGTTTTTCTTCATTATTGTCATTGCGTGTTCTTAAGTTTTACCCCTATTAGATGGTA
AGAACAATTAATGCAGTTTTGCACAAATATTTTTACATTCTGATCATTCAGTTCTGTCATTGTAATCTTTGTTGTTAGAAACAAATGATG
AAAACATAGGGGTTCTGTAAACTTTTGTAATGCTATGAATTCTGTTTAAATTTTGGGCTGTCTATTTTCTGCTGAAACCATGCAAAATTG
AGCTTTGGTGGGGCTGGGAGGGGGTTATGTATTCATGGGACCTTTAATTTGTACAGAACACAGAACTTATTTCTGTCAGTTATTTAATAC
ATTGAAAATTTAGTGAAATGTTCAAAGAGAATAGATGTTTCCCAAAACAACAATCTTTATGTTAAAAATAGTCATTAAAAGATCTGTTGT
AATATATGGTGGATATTTTTCTTTAATTTCAAACATTACCTCTGAAATGTGTATCTTTTCTTTTTTATCTTACCATTAATTTTAAATCTA
GTGGATTGGTTTTCAACATCGTGCCTGCCGATATGCCTACAGAATCATCTGTAAGTGTCAAAATGAACCCACGTTGTTAGCCATAATTTT
GATTATGCCTTTATTTCTCCTTTCTTGAAAAAAAAAAGGTGTTATTTTGACAATTAGGCATAACATTGTTTTGTAGATTATCTTTTAATG

>33523_33523_4_GNA12-ADSS_GNA12_chr7_2834562_ENST00000275364_ADSS_chr1_244601070_ENST00000366535_length(amino acids)=570AA_BP=175
MSGVVRTLSRCLLPAEAGGARERRAGSGARDAEREARRRSRDIDALLARERRAVRRLVKILLLGAGESGKSTFLKQMRIIHGREFDQKAL
LEFRDTIFDNILKGSRVLVDARDKLGIPWQYSENEKHGMFLMAFENKAGLPVEPATFQLYVPALSALWRDSGIREAFSRRSEFQLGGNNA
GHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAEKNVQKGKGLEGWEKRLIISDRAHIVFDFHQAADGIQEQQRQEQAG
KNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDGFSERFKVLANQYKSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHGPP
KKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKR
RCGWLDLVLLKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIPANQEVLNKVEVQYKTLPGWNTDISNARAFKELPVNAQ

--------------------------------------------------------------
>33523_33523_5_GNA12-ADSS_GNA12_chr7_2834562_ENST00000407904_ADSS_chr1_244601070_ENST00000366535_length(transcript)=2957nt_BP=677nt
ATTTAAGCAGCCTCCTTGACTGTAGGTCCGCTGACTGGCTTCCTCCTTGAGAGCACACTCACAGTGCCGGACCGCAGGCACCTCGCCGAT
GTTCCTGTCCACTTGCTTTTTGTATTGCTCCTTCTCCAGTGAGCTTGGAAGCCTCATGCGGGCAAGGCCTTGTCTGTCTGGTTCTCTGTT
GTGTCCTCGGAGCCTGCCACAGTGGCGGCGCTTGGTGGCTTTGACAGGGGACTGGATTGGGTGGAAGGGGCGAGATTAGACCTGGATACA
GTGACGTCCTTGTCAGCCATGCCGAGTGCAGAGCGCCTACTGTATTGTAGGCATTTGAAATGAAACGGAGAATGTTTCCCAGGCCGTGCC
TAGCAAGGATGCCTGGCAGTCGTGGTTCGGGAAGCACACCAGATGGAAACCGAAAGTGCTGCCGTTTTGAGCACCTACTCATTGCACACC
CTGGGTCCAGGGGCTCAAGGGTTCTTGTTGATGCACGAGATAAGCTTGGCATTCCTTGGCAGTATTCTGAAAATGAGAAGCATGGGATGT
TCCTGATGGCCTTCGAGAACAAGGCGGGGCTGCCTGTGGAGCCGGCCACCTTCCAGCTGTACGTCCCGGCCCTGAGCGCACTCTGGAGGG
ATTCTGGCATCAGGGAGGCTTTCAGCCGGAGAAGCGAGTTTCAGCTGGGAGGAAATAATGCTGGCCATACAGTTGTTGTGGATTCTGTGG
AATATGATTTTCATCTCTTACCCAGTGGAATAATTAATCCAAATGTCACTGCATTCATTGGAAATGGTGTGGTAATTCATCTACCTGGAT
TGTTTGAAGAAGCAGAGAAAAATGTTCAAAAAGGAAAAGGACTAGAAGGCTGGGAAAAAAGGCTTATTATATCTGACAGAGCTCATATTG
TATTTGATTTTCATCAAGCAGCTGATGGTATCCAGGAACAACAGAGACAAGAACAAGCAGGAAAAAATTTGGGTACAACAAAAAAGGGCA
TTGGCCCAGTTTATTCGTCCAAAGCTGCTCGGAGTGGACTCAGGATGTGCGACCTTGTTTCTGACTTTGATGGCTTCTCTGAGAGGTTTA
AAGTTCTAGCTAACCAATACAAATCTATATACCCCACTTTGGAAATAGACATTGAAGGTGAATTACAAAAACTCAAGGGTTATATGGAAA
AGATTAAACCAATGGTGAGAGATGGAGTTTATTTTCTATATGAGGCCCTACATGGACCACCAAAGAAAATCTTGGTAGAAGGTGCAAATG
CAGCACTATTAGATATTGATTTTGGGACTTACCCTTTTGTAACCTCTTCAAATTGTACTGTTGGAGGTGTTTGTACTGGTTTGGGTATGC
CACCTCAAAATGTTGGAGAAGTGTATGGAGTTGTGAAAGCTTATACAACTAGAGTTGGTATTGGTGCCTTTCCTACAGAGCAAGACAATG
AAATTGGAGAATTATTACAAACAAGGGGTAGAGAGTTTGGTGTAACTACTGGAAGGAAAAGAAGATGTGGCTGGTTGGACCTCGTTTTGC
TCAAATATGCTCATATGATCAATGGATTTACTGCGTTGGCACTTACCAAGTTGGATATTTTGGACATGTTTACGGAAATCAAAGTTGGAG
TTGCTTACAAGTTAGATGGTGAAATCATACCTCATATCCCAGCAAACCAAGAAGTCTTAAATAAAGTTGAAGTTCAATATAAGACTCTCC
CAGGATGGAACACAGACATATCAAATGCAAGGGCGTTTAAAGAACTACCTGTTAATGCACAAAACTATGTTCGATTTATTGAAGATGAGC
TTCAAATTCCAGTTAAGTGGATTGGTGTTGGTAAATCCAGAGAATCTATGATTCAACTCTTTTAATGATTGCCAGTAATGCAAGAAACAC
TCCTTGAGAGGGAGGGGAAAAGACTTTCTTAAATATTTCATTTATGACCTGCAAATTCAAGAATAAAGACACTGAAGTAAGTTTGAAGCC
CTACAGTTGTTTCCAGTCTTTTCAGATGGATGCCTACTGTGGAGATTAACTTTGGCATATTCCAGTGTCAGCTTTCTTTAGCTGGAATTG
CCAAATCATTTGTTGCTCCTGCTGCTCTCATGGTGCCACGTTTTTTTTTTCAATGTTTAGTAATAGTATAATCCATGTTGTTTGATATCA
AAAGTAGAATTACTTTTAATGTAGTTTTTCTTCATTATTGTCATTGCGTGTTCTTAAGTTTTACCCCTATTAGATGGTAAGAACAATTAA
TGCAGTTTTGCACAAATATTTTTACATTCTGATCATTCAGTTCTGTCATTGTAATCTTTGTTGTTAGAAACAAATGATGAAAACATAGGG
GTTCTGTAAACTTTTGTAATGCTATGAATTCTGTTTAAATTTTGGGCTGTCTATTTTCTGCTGAAACCATGCAAAATTGAGCTTTGGTGG
GGCTGGGAGGGGGTTATGTATTCATGGGACCTTTAATTTGTACAGAACACAGAACTTATTTCTGTCAGTTATTTAATACATTGAAAATTT
AGTGAAATGTTCAAAGAGAATAGATGTTTCCCAAAACAACAATCTTTATGTTAAAAATAGTCATTAAAAGATCTGTTGTAATATATGGTG
GATATTTTTCTTTAATTTCAAACATTACCTCTGAAATGTGTATCTTTTCTTTTTTATCTTACCATTAATTTTAAATCTAGTGGATTGGTT
TTCAACATCGTGCCTGCCGATATGCCTACAGAATCATCTGTAAGTGTCAAAATGAACCCACGTTGTTAGCCATAATTTTGATTATGCCTT
TATTTCTCCTTTCTTGAAAAAAAAAAGGTGTTATTTTGACAATTAGGCATAACATTGTTTTGTAGATTATCTTTTAATGAACTATTTTAA

>33523_33523_5_GNA12-ADSS_GNA12_chr7_2834562_ENST00000407904_ADSS_chr1_244601070_ENST00000366535_length(amino acids)=511AA_BP=116
MKRRMFPRPCLARMPGSRGSGSTPDGNRKCCRFEHLLIAHPGSRGSRVLVDARDKLGIPWQYSENEKHGMFLMAFENKAGLPVEPATFQL
YVPALSALWRDSGIREAFSRRSEFQLGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAEKNVQKGKGLEGWEK
RLIISDRAHIVFDFHQAADGIQEQQRQEQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDGFSERFKVLANQYKSIYPTLEIDIEG
ELQKLKGYMEKIKPMVRDGVYFLYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVG
IGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIPANQEVL

--------------------------------------------------------------
>33523_33523_6_GNA12-ADSS_GNA12_chr7_2834562_ENST00000544127_ADSS_chr1_244601070_ENST00000366535_length(transcript)=2660nt_BP=380nt
GCGAGCGGCGCGCGGTCCGGCGCCTGGTGAAGATCCTGCTGCTGGGCGCGGGCGAGAGCGGCAAGTCCACGTTCCTCAAGCAGATGCGCA
TCATCCACGGCCGCGAGTTCGACCAGAAGGCGCTGCTGGAGTTCCGCGACACCATCTTCGACAACATCCTCAAGGGCTCAAGGGTTCTTG
TTGATGCACGAGATAAGCTTGGCATTCCTTGGCAGTATTCTGAAAATGAGAAGCATGGGATGTTCCTGATGGCCTTCGAGAACAAGGCGG
GGCTGCCTGTGGAGCCGGCCACCTTCCAGCTGTACGTCCCGGCCCTGAGCGCACTCTGGAGGGATTCTGGCATCAGGGAGGCTTTCAGCC
GGAGAAGCGAGTTTCAGCTGGGAGGAAATAATGCTGGCCATACAGTTGTTGTGGATTCTGTGGAATATGATTTTCATCTCTTACCCAGTG
GAATAATTAATCCAAATGTCACTGCATTCATTGGAAATGGTGTGGTAATTCATCTACCTGGATTGTTTGAAGAAGCAGAGAAAAATGTTC
AAAAAGGAAAAGGACTAGAAGGCTGGGAAAAAAGGCTTATTATATCTGACAGAGCTCATATTGTATTTGATTTTCATCAAGCAGCTGATG
GTATCCAGGAACAACAGAGACAAGAACAAGCAGGAAAAAATTTGGGTACAACAAAAAAGGGCATTGGCCCAGTTTATTCGTCCAAAGCTG
CTCGGAGTGGACTCAGGATGTGCGACCTTGTTTCTGACTTTGATGGCTTCTCTGAGAGGTTTAAAGTTCTAGCTAACCAATACAAATCTA
TATACCCCACTTTGGAAATAGACATTGAAGGTGAATTACAAAAACTCAAGGGTTATATGGAAAAGATTAAACCAATGGTGAGAGATGGAG
TTTATTTTCTATATGAGGCCCTACATGGACCACCAAAGAAAATCTTGGTAGAAGGTGCAAATGCAGCACTATTAGATATTGATTTTGGGA
CTTACCCTTTTGTAACCTCTTCAAATTGTACTGTTGGAGGTGTTTGTACTGGTTTGGGTATGCCACCTCAAAATGTTGGAGAAGTGTATG
GAGTTGTGAAAGCTTATACAACTAGAGTTGGTATTGGTGCCTTTCCTACAGAGCAAGACAATGAAATTGGAGAATTATTACAAACAAGGG
GTAGAGAGTTTGGTGTAACTACTGGAAGGAAAAGAAGATGTGGCTGGTTGGACCTCGTTTTGCTCAAATATGCTCATATGATCAATGGAT
TTACTGCGTTGGCACTTACCAAGTTGGATATTTTGGACATGTTTACGGAAATCAAAGTTGGAGTTGCTTACAAGTTAGATGGTGAAATCA
TACCTCATATCCCAGCAAACCAAGAAGTCTTAAATAAAGTTGAAGTTCAATATAAGACTCTCCCAGGATGGAACACAGACATATCAAATG
CAAGGGCGTTTAAAGAACTACCTGTTAATGCACAAAACTATGTTCGATTTATTGAAGATGAGCTTCAAATTCCAGTTAAGTGGATTGGTG
TTGGTAAATCCAGAGAATCTATGATTCAACTCTTTTAATGATTGCCAGTAATGCAAGAAACACTCCTTGAGAGGGAGGGGAAAAGACTTT
CTTAAATATTTCATTTATGACCTGCAAATTCAAGAATAAAGACACTGAAGTAAGTTTGAAGCCCTACAGTTGTTTCCAGTCTTTTCAGAT
GGATGCCTACTGTGGAGATTAACTTTGGCATATTCCAGTGTCAGCTTTCTTTAGCTGGAATTGCCAAATCATTTGTTGCTCCTGCTGCTC
TCATGGTGCCACGTTTTTTTTTTCAATGTTTAGTAATAGTATAATCCATGTTGTTTGATATCAAAAGTAGAATTACTTTTAATGTAGTTT
TTCTTCATTATTGTCATTGCGTGTTCTTAAGTTTTACCCCTATTAGATGGTAAGAACAATTAATGCAGTTTTGCACAAATATTTTTACAT
TCTGATCATTCAGTTCTGTCATTGTAATCTTTGTTGTTAGAAACAAATGATGAAAACATAGGGGTTCTGTAAACTTTTGTAATGCTATGA
ATTCTGTTTAAATTTTGGGCTGTCTATTTTCTGCTGAAACCATGCAAAATTGAGCTTTGGTGGGGCTGGGAGGGGGTTATGTATTCATGG
GACCTTTAATTTGTACAGAACACAGAACTTATTTCTGTCAGTTATTTAATACATTGAAAATTTAGTGAAATGTTCAAAGAGAATAGATGT
TTCCCAAAACAACAATCTTTATGTTAAAAATAGTCATTAAAAGATCTGTTGTAATATATGGTGGATATTTTTCTTTAATTTCAAACATTA
CCTCTGAAATGTGTATCTTTTCTTTTTTATCTTACCATTAATTTTAAATCTAGTGGATTGGTTTTCAACATCGTGCCTGCCGATATGCCT
ACAGAATCATCTGTAAGTGTCAAAATGAACCCACGTTGTTAGCCATAATTTTGATTATGCCTTTATTTCTCCTTTCTTGAAAAAAAAAAG
GTGTTATTTTGACAATTAGGCATAACATTGTTTTGTAGATTATCTTTTAATGAACTATTTTAAATGTTAAATTAGGTGCCACTTAAATTT

>33523_33523_6_GNA12-ADSS_GNA12_chr7_2834562_ENST00000544127_ADSS_chr1_244601070_ENST00000366535_length(amino acids)=514AA_BP=119
MVKILLLGAGESGKSTFLKQMRIIHGREFDQKALLEFRDTIFDNILKGSRVLVDARDKLGIPWQYSENEKHGMFLMAFENKAGLPVEPAT
FQLYVPALSALWRDSGIREAFSRRSEFQLGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAEKNVQKGKGLEG
WEKRLIISDRAHIVFDFHQAADGIQEQQRQEQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDGFSERFKVLANQYKSIYPTLEID
IEGELQKLKGYMEKIKPMVRDGVYFLYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTT
RVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIPANQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GNA12-ADSS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GNA12-ADSS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GNA12-ADSS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource