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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AKAP6-PRKD1 (FusionGDB2 ID:3353)

Fusion Gene Summary for AKAP6-PRKD1

check button Fusion gene summary
Fusion gene informationFusion gene name: AKAP6-PRKD1
Fusion gene ID: 3353
HgeneTgene
Gene symbol

AKAP6

PRKD1

Gene ID

9472

5587

Gene nameA-kinase anchoring protein 6protein kinase D1
SynonymsADAP100|ADAP6|AKAP100|PRKA6|mAKAPCHDED|PKC-MU|PKCM|PKD|PRKCM
Cytomap

14q12

14q12

Type of geneprotein-codingprotein-coding
DescriptionA-kinase anchor protein 6A kinase (PRKA) anchor protein 6A-kinase anchor protein 100 kDaAKAP 100AKAP-6protein kinase A anchoring protein 6serine/threonine-protein kinase D1nPKC-D1nPKC-muprotein kinase C mu typeprotein kinase C, muprotein kinase D
Modification date2020031320200315
UniProtAcc

Q13023

.
Ensembl transtripts involved in fusion geneENST00000280979, ENST00000557272, 
ENST00000557354, ENST00000554449, 
ENST00000551644, ENST00000331968, 
ENST00000415220, 
Fusion gene scores* DoF score9 X 8 X 4=28814 X 13 X 7=1274
# samples 913
** MAII scorelog2(9/288*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/1274*10)=-3.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AKAP6 [Title/Abstract] AND PRKD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAKAP6(33069998)-PRKD1(30095762), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAKAP6

GO:0060306

regulation of membrane repolarization

11299204

HgeneAKAP6

GO:0071320

cellular response to cAMP

11299204

HgeneAKAP6

GO:1901381

positive regulation of potassium ion transmembrane transport

11299204

HgeneAKAP6

GO:1902261

positive regulation of delayed rectifier potassium channel activity

11299204

TgenePRKD1

GO:0006468

protein phosphorylation

24623306

TgenePRKD1

GO:0018105

peptidyl-serine phosphorylation

18440775

TgenePRKD1

GO:0018107

peptidyl-threonine phosphorylation

22095288

TgenePRKD1

GO:0034599

cellular response to oxidative stress

12505989

TgenePRKD1

GO:0046777

protein autophosphorylation

24623306


check buttonFusion gene breakpoints across AKAP6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PRKD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EE-A181-06AAKAP6chr14

33069998

-PRKD1chr14

30095762

-
ChimerDB4SKCMTCGA-EE-A181-06AAKAP6chr14

33069998

+PRKD1chr14

30095762

-


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Fusion Gene ORF analysis for AKAP6-PRKD1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000280979ENST00000551644AKAP6chr14

33069998

+PRKD1chr14

30095762

-
5CDS-intronENST00000557272ENST00000551644AKAP6chr14

33069998

+PRKD1chr14

30095762

-
5CDS-intronENST00000557354ENST00000551644AKAP6chr14

33069998

+PRKD1chr14

30095762

-
In-frameENST00000280979ENST00000331968AKAP6chr14

33069998

+PRKD1chr14

30095762

-
In-frameENST00000280979ENST00000415220AKAP6chr14

33069998

+PRKD1chr14

30095762

-
In-frameENST00000557272ENST00000331968AKAP6chr14

33069998

+PRKD1chr14

30095762

-
In-frameENST00000557272ENST00000415220AKAP6chr14

33069998

+PRKD1chr14

30095762

-
In-frameENST00000557354ENST00000331968AKAP6chr14

33069998

+PRKD1chr14

30095762

-
In-frameENST00000557354ENST00000415220AKAP6chr14

33069998

+PRKD1chr14

30095762

-
intron-3CDSENST00000554449ENST00000331968AKAP6chr14

33069998

+PRKD1chr14

30095762

-
intron-3CDSENST00000554449ENST00000415220AKAP6chr14

33069998

+PRKD1chr14

30095762

-
intron-intronENST00000554449ENST00000551644AKAP6chr14

33069998

+PRKD1chr14

30095762

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000280979AKAP6chr1433069998+ENST00000331968PRKD1chr1430095762-4671290017039131247
ENST00000280979AKAP6chr1433069998+ENST00000415220PRKD1chr1430095762-4210290017039131247
ENST00000557354AKAP6chr1433069998+ENST00000331968PRKD1chr1430095762-460028299938421247
ENST00000557354AKAP6chr1433069998+ENST00000415220PRKD1chr1430095762-413928299938421247
ENST00000557272AKAP6chr1433069998+ENST00000331968PRKD1chr1430095762-454427734337861247
ENST00000557272AKAP6chr1433069998+ENST00000415220PRKD1chr1430095762-408327734337861247

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000280979ENST00000331968AKAP6chr1433069998+PRKD1chr1430095762-0.0011513830.99884856
ENST00000280979ENST00000415220AKAP6chr1433069998+PRKD1chr1430095762-0.0017574520.9982425
ENST00000557354ENST00000331968AKAP6chr1433069998+PRKD1chr1430095762-0.0010001940.9989998
ENST00000557354ENST00000415220AKAP6chr1433069998+PRKD1chr1430095762-0.0015065650.99849343
ENST00000557272ENST00000331968AKAP6chr1433069998+PRKD1chr1430095762-0.0009450380.99905497
ENST00000557272ENST00000415220AKAP6chr1433069998+PRKD1chr1430095762-0.0014344210.9985656

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Fusion Genomic Features for AKAP6-PRKD1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AKAP6-PRKD1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:33069998/chr14:30095762)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AKAP6

Q13023

.
FUNCTION: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAKAP6chr14:33069998chr14:30095762ENST00000280979+714762_8489102779.3333333333335RepeatNote=Spectrin 1
TgenePRKD1chr14:33069998chr14:30095762ENST000003319681018583_839575913.0DomainProtein kinase
TgenePRKD1chr14:33069998chr14:30095762ENST000003319681018589_597575913.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAKAP6chr14:33069998chr14:30095762ENST00000280979+7141560_17019102779.3333333333335Compositional biasNote=Ser-rich
HgeneAKAP6chr14:33069998chr14:30095762ENST00000280979+7142063_20769102779.3333333333335RegionNote=PKA-RII subunit binding domain
HgeneAKAP6chr14:33069998chr14:30095762ENST00000280979+7141036_11509102779.3333333333335RepeatNote=Spectrin 2
TgenePRKD1chr14:33069998chr14:30095762ENST00000331968101817_26575913.0Compositional biasNote=Poly-Ala
TgenePRKD1chr14:33069998chr14:30095762ENST000003319681018200_203575913.0Compositional biasNote=Poly-Arg
TgenePRKD1chr14:33069998chr14:30095762ENST000003319681018422_541575913.0DomainPH
TgenePRKD1chr14:33069998chr14:30095762ENST000003319681018146_196575913.0Zinc fingerPhorbol-ester/DAG-type 1
TgenePRKD1chr14:33069998chr14:30095762ENST000003319681018270_320575913.0Zinc fingerPhorbol-ester/DAG-type 2


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Fusion Gene Sequence for AKAP6-PRKD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3353_3353_1_AKAP6-PRKD1_AKAP6_chr14_33069998_ENST00000280979_PRKD1_chr14_30095762_ENST00000331968_length(transcript)=4671nt_BP=2900nt
AGTCTTTCCCATAATGAGCTGCATCATCTGAACTGATGTCACAGCATCATGCAGCAGGTCAAACAAGGCATCTCCTAGTATTGCATCCTA
CAGATGTGCTGTAAACATCAAAAGAAGACGGTGGGATCAGGAGATGCTGTTTTGGAAAGAAGTGAGGTTTAGACTTCTCCATGTTAACCA
TGAGCGTGACACTTTCCCCCCTGAGGTCACAGGACCTGGATCCCATGGCTACTGATGCTTCACCCATGGCCATCAACATGACACCCACTG
TGGAGCAGGGTGAGGGAGAAGAGGCAATGAAGGACATGGACTCTGACCAGCAGTATGAAAAGCCACCCCCACTACACACAGGGGCTGACT
GGAAGATTGTCCTCCACTTACCTGAAATTGAGACCTGGCTCCGGATGACCTCAGAGAGGGTCCGAGACCTAACCTATTCAGTCCAGCAGG
ATTCGGACAGCAAGCATGTGGATGTACATCTAGTTCAACTAAAGGACATTTGTGAAGATATTTCTGATCATGTTGAGCAAATCCATGCCC
TCCTTGAAACAGAGTTCTCCCTAAAGCTGCTGTCTTACTCTGTCAACGTGATAGTGGACATCCACGCAGTGCAGCTCCTCTGGCACCAGC
TTCGAGTCTCAGTGCTGGTTCTGCGGGAGCGCATTCTGCAAGGTCTGCAGGACGCCAATGGCAACTACACTAGGCAGACGGACATTCTGC
AAGCTTTCTCTGAAGAGACAAAAGAGGGCCGGCTTGATTCTCTAACAGAAGTGGATGACTCAGGACAATTAACCATCAAATGTTCTCAAA
ATTACTTGTCTCTGGATTGTGGCATTACTGCATTCGAACTGTCTGACTACAGTCCAAGTGAGGATTTGCTCAGTGGGCTAGGTGACATGA
CCTCTAGCCAAGTCAAAACCAAACCCTTTGACTCTTGGAGCTACAGTGAGATGGAAAAGGAGTTTCCTGAGCTTATCCGAAGTGTTGGTT
TACTTACGGTAGCTGCTGACTCTATCTCTACCAATGGCAGTGAAGCAGTTACTGAGGAGGTATCTCAAGTATCTCTCTCAGTAGACGACA
AAGGTGGATGTGAGGAAGACAATGCTTCTGCAGTCGAAGAGCAACCAGGCTTAACACTGGGGGTGTCATCATCTTCAGGAGAAGCTCTGA
CAAATGCTGCTCAACCCTCCTCTGAGACTGTGCAGCAAGAATCCAGTTCCTCCTCCCATCATGATGCAAAGAATCAGCAGCCTGTTCCTT
GTGAAAATGCAACCCCCAAACGAACCATCAGAGATTGCTTTAATTATAACGAGGACTCTCCCACGCAGCCTACATTGCCAAAAAGAGGAC
TTTTTCTTAAAGAGGAAACTTTTAAGAATGATCTGAAAGGCAATGGTGGAAAGAGGCAAATGGTTGATCTAAAGCCTGAGATGAGCAGAA
GCACCCCTTCGCTAGTAGATCCTCCTGACAGATCCAAACTTTGCCTGGTATTGCAGTCTTCTTACCCCAACAGCCCTTCTGCTGCCAGCC
AGTCTTATGAGTGTTTACACAAGGTGGGGAATGGGAACCTTGAAAACACAGTCAAATTTCACATTAAAGAAATTTCTTCCAGCCTGGGAA
GGCTTAACGACTGCTATAAAGAGAAATCTCGACTTAAAAAGCCACACAAGACCTCAGAAGAGGTGCCTCCATGCCGAACACCTAAACGGG
GGACTGGTTCAGGCAAACAAGCTAAAAATACAAAGAGCTCAGCAGTGCCAAATGGAGAGCTTTCTTATACTTCCAAGGCCATAGAGGGGC
CACAAACAAATTCTGCTTCCACATCCTCACTTGAGCCTTGTAATCAGAGAAGTTGGAATGCCAAATTGCAATTGCAGTCAGAAACATCCA
GTTCACCAGCTTTTACTCAGAGCAGTGAATCCTCTGTTGGCTCAGACAACATCATGTCTCCGGTGCCACTTCTTTCAAAACACAAAAGCA
AAAAAGGTCAAGCCTCCTCTCCAAGTCACGTCACTAGGAATGGTGAGGTTGTGGAGGCCTGGTATGGCTCTGATGAATACCTAGCACTGC
CCTCTCACCTTAAGCAGACAGAAGTATTGGCTTTGAAGTTGGAAAACCTAACAAAGCTTCTGCCTCAGAAACCCAGAGGAGAAACCATCC
AGAATATTGATGACTGGGAACTGTCTGAAATGAATTCAGATTCTGAAATCTATCCAACCTATCATGTCAAAAAGAAGCATACAAGGCTAG
GCAGGGTGTCTCCAAGCTCATCTAGTGACATAGCCTCTTCACTAGGGGAGAGCATTGAATCTGGGCCCCTGAGTGACATTCTTTCTGATG
AGGAGTCCAGTATGCCTCTCGCTGGCATGAAAAAGTATGCTGATGAGAAGTCAGAAAGAGCTTCATCCTCTGAGAAAAATGAGAGCCATT
CTGCCACTAAATCAGCTTTAATTCAGAAACTGATGCAAGATATTCAGCACCAAGACAACTATGAAGCCATATGGGAAAAAATAGAGGGGT
TTGTAAACAAACTGGATGAATTCATTCAATGGTTAAATGAAGCCATGGAAACTACAGAAAATTGGACTCCCCCTAAAGCAGAGATGGATG
ACCTTAAACTGTATCTGGAGACACACTTGAGTTTTAAGTTGAATGTAGACAGTCATTGTGCTCTCAAGGAAGCTGTGGAGGAGGAAGGAC
ACCAACTTCTTGAGCTTATTGCATCTCACAAAGCAGGACTGAAGGACATGCTGCGGATGATTGCAAGTCAATGGAAGGAGCTGCAGAGGC
AAATCAAACGGCAGCACAGCTGGATTCTCAGGGCTCTGGATACCATCAAAGCCGAGATACTGGCTACTGATGTGTCTGTGGAGGATGAGG
AAGGGACTGGAAGCCCCAAGGACATCAGCACAGTATATCAGATTTTTCCTGATGAAGTACTGGGTTCTGGACAGTTTGGAATTGTTTATG
GAGGAAAACATCGTAAAACAGGAAGAGATGTAGCTATTAAAATCATTGACAAATTACGATTTCCAACAAAACAAGAAAGCCAGCTTCGTA
ATGAGGTTGCAATTCTACAGAACCTTCATCACCCTGGTGTTGTAAATTTGGAGTGTATGTTTGAGACGCCTGAAAGAGTGTTTGTTGTTA
TGGAAAAACTCCATGGAGACATGCTGGAAATGATCTTGTCAAGTGAAAAGGGCAGGTTGCCAGAGCACATAACGAAGTTTTTAATTACTC
AGATACTCGTGGCTTTGCGGCACCTTCATTTTAAAAATATCGTTCACTGTGACCTCAAACCAGAAAATGTGTTGCTAGCCTCAGCTGATC
CTTTTCCTCAGGTGAAACTTTGTGATTTTGGTTTTGCCCGGATCATTGGAGAGAAGTCTTTCCGGAGGTCAGTGGTGGGTACCCCCGCTT
ACCTGGCTCCTGAGGTCCTAAGGAACAAGGGCTACAATCGCTCTCTAGACATGTGGTCTGTTGGGGTCATCATCTATGTAAGCCTAAGCG
GCACATTCCCATTTAATGAAGATGAAGACATACACGACCAAATTCAGAATGCAGCTTTCATGTATCCACCAAATCCCTGGAAGGAAATAT
CTCATGAAGCCATTGATCTTATCAACAATTTGCTGCAAGTAAAAATGAGAAAGCGCTACAGTGTGGATAAGACCTTGAGCCACCCTTGGC
TACAGGACTATCAGACCTGGTTAGATTTGCGAGAGCTGGAATGCAAAATCGGGGAGCGCTACATCACCCATGAAAGTGATGACCTGAGGT
GGGAGAAGTATGCAGGCGAGCAGGGGCTGCAGTACCCCACACACCTGATCAATCCAAGTGCTAGCCACAGTGACACTCCTGAGACTGAAG
AAACAGAAATGAAAGCCCTCGGTGAGCGTGTCAGCATCCTCTGAGTTCCATCTCCTATAATCTGTCAAAACACTGTGGAACTAATAAATA
CATACGGTCAGGTTTAACATTTGCCTTGCAGAACTGCCATTATTTTCTGTCAGATGAGAACAAAGCTGTTAAACTGTTAGCACTGTTGAT
GTATCTGAGTTGCCAAGACAAATCAACAGAAGCATTTGTATTTTGTGTGACCAACTGTGTTGTATTAACAAAAGTTCCCTGAAACACGAA
ACTTGTTATTGTGAATGATTCATGTTATATTTAATGCATTAAACCTGTCTCCACTGTGCCTTTGCAAATCAGTGTTTTTCTTACTGGAGC
TTCATTTTGGTAAGAGACAGAATGTATCTGTGAAGTAGTTCTGTTTGGTGTGTCCCATTGGTGTTGTCATTGTAAACAAACTCTTGAAGA
GTCGATTATTTCCAGTGTTCTATGAACAACTCCAAAACCCATGTGGGAAAAAAATGAATGAGGAGGGTAGGGAATAAAATCCTAAGACAC
AAATGCATGAACAAGTTTTAATGTATAGTTTTGAATCCTTTGCCTGCCTGGTGTGCCTCAGTATATTTAAACTCAAGACAATGCACCTAG
CTGTGCAAGACCTAGTGCTCTTAAGCCTAAATGCCTTAGAAATGTAAACTGCCATATATAACAGATACATTTCCCTCTTTCTTATAATAC

>3353_3353_1_AKAP6-PRKD1_AKAP6_chr14_33069998_ENST00000280979_PRKD1_chr14_30095762_ENST00000331968_length(amino acids)=1247AA_BP=910
MLTMSVTLSPLRSQDLDPMATDASPMAINMTPTVEQGEGEEAMKDMDSDQQYEKPPPLHTGADWKIVLHLPEIETWLRMTSERVRDLTYS
VQQDSDSKHVDVHLVQLKDICEDISDHVEQIHALLETEFSLKLLSYSVNVIVDIHAVQLLWHQLRVSVLVLRERILQGLQDANGNYTRQT
DILQAFSEETKEGRLDSLTEVDDSGQLTIKCSQNYLSLDCGITAFELSDYSPSEDLLSGLGDMTSSQVKTKPFDSWSYSEMEKEFPELIR
SVGLLTVAADSISTNGSEAVTEEVSQVSLSVDDKGGCEEDNASAVEEQPGLTLGVSSSSGEALTNAAQPSSETVQQESSSSSHHDAKNQQ
PVPCENATPKRTIRDCFNYNEDSPTQPTLPKRGLFLKEETFKNDLKGNGGKRQMVDLKPEMSRSTPSLVDPPDRSKLCLVLQSSYPNSPS
AASQSYECLHKVGNGNLENTVKFHIKEISSSLGRLNDCYKEKSRLKKPHKTSEEVPPCRTPKRGTGSGKQAKNTKSSAVPNGELSYTSKA
IEGPQTNSASTSSLEPCNQRSWNAKLQLQSETSSSPAFTQSSESSVGSDNIMSPVPLLSKHKSKKGQASSPSHVTRNGEVVEAWYGSDEY
LALPSHLKQTEVLALKLENLTKLLPQKPRGETIQNIDDWELSEMNSDSEIYPTYHVKKKHTRLGRVSPSSSSDIASSLGESIESGPLSDI
LSDEESSMPLAGMKKYADEKSERASSSEKNESHSATKSALIQKLMQDIQHQDNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKA
EMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRALDTIKAEILATDVSV
EDEEGTGSPKDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERV
FVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVG
TPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLS

--------------------------------------------------------------
>3353_3353_2_AKAP6-PRKD1_AKAP6_chr14_33069998_ENST00000280979_PRKD1_chr14_30095762_ENST00000415220_length(transcript)=4210nt_BP=2900nt
AGTCTTTCCCATAATGAGCTGCATCATCTGAACTGATGTCACAGCATCATGCAGCAGGTCAAACAAGGCATCTCCTAGTATTGCATCCTA
CAGATGTGCTGTAAACATCAAAAGAAGACGGTGGGATCAGGAGATGCTGTTTTGGAAAGAAGTGAGGTTTAGACTTCTCCATGTTAACCA
TGAGCGTGACACTTTCCCCCCTGAGGTCACAGGACCTGGATCCCATGGCTACTGATGCTTCACCCATGGCCATCAACATGACACCCACTG
TGGAGCAGGGTGAGGGAGAAGAGGCAATGAAGGACATGGACTCTGACCAGCAGTATGAAAAGCCACCCCCACTACACACAGGGGCTGACT
GGAAGATTGTCCTCCACTTACCTGAAATTGAGACCTGGCTCCGGATGACCTCAGAGAGGGTCCGAGACCTAACCTATTCAGTCCAGCAGG
ATTCGGACAGCAAGCATGTGGATGTACATCTAGTTCAACTAAAGGACATTTGTGAAGATATTTCTGATCATGTTGAGCAAATCCATGCCC
TCCTTGAAACAGAGTTCTCCCTAAAGCTGCTGTCTTACTCTGTCAACGTGATAGTGGACATCCACGCAGTGCAGCTCCTCTGGCACCAGC
TTCGAGTCTCAGTGCTGGTTCTGCGGGAGCGCATTCTGCAAGGTCTGCAGGACGCCAATGGCAACTACACTAGGCAGACGGACATTCTGC
AAGCTTTCTCTGAAGAGACAAAAGAGGGCCGGCTTGATTCTCTAACAGAAGTGGATGACTCAGGACAATTAACCATCAAATGTTCTCAAA
ATTACTTGTCTCTGGATTGTGGCATTACTGCATTCGAACTGTCTGACTACAGTCCAAGTGAGGATTTGCTCAGTGGGCTAGGTGACATGA
CCTCTAGCCAAGTCAAAACCAAACCCTTTGACTCTTGGAGCTACAGTGAGATGGAAAAGGAGTTTCCTGAGCTTATCCGAAGTGTTGGTT
TACTTACGGTAGCTGCTGACTCTATCTCTACCAATGGCAGTGAAGCAGTTACTGAGGAGGTATCTCAAGTATCTCTCTCAGTAGACGACA
AAGGTGGATGTGAGGAAGACAATGCTTCTGCAGTCGAAGAGCAACCAGGCTTAACACTGGGGGTGTCATCATCTTCAGGAGAAGCTCTGA
CAAATGCTGCTCAACCCTCCTCTGAGACTGTGCAGCAAGAATCCAGTTCCTCCTCCCATCATGATGCAAAGAATCAGCAGCCTGTTCCTT
GTGAAAATGCAACCCCCAAACGAACCATCAGAGATTGCTTTAATTATAACGAGGACTCTCCCACGCAGCCTACATTGCCAAAAAGAGGAC
TTTTTCTTAAAGAGGAAACTTTTAAGAATGATCTGAAAGGCAATGGTGGAAAGAGGCAAATGGTTGATCTAAAGCCTGAGATGAGCAGAA
GCACCCCTTCGCTAGTAGATCCTCCTGACAGATCCAAACTTTGCCTGGTATTGCAGTCTTCTTACCCCAACAGCCCTTCTGCTGCCAGCC
AGTCTTATGAGTGTTTACACAAGGTGGGGAATGGGAACCTTGAAAACACAGTCAAATTTCACATTAAAGAAATTTCTTCCAGCCTGGGAA
GGCTTAACGACTGCTATAAAGAGAAATCTCGACTTAAAAAGCCACACAAGACCTCAGAAGAGGTGCCTCCATGCCGAACACCTAAACGGG
GGACTGGTTCAGGCAAACAAGCTAAAAATACAAAGAGCTCAGCAGTGCCAAATGGAGAGCTTTCTTATACTTCCAAGGCCATAGAGGGGC
CACAAACAAATTCTGCTTCCACATCCTCACTTGAGCCTTGTAATCAGAGAAGTTGGAATGCCAAATTGCAATTGCAGTCAGAAACATCCA
GTTCACCAGCTTTTACTCAGAGCAGTGAATCCTCTGTTGGCTCAGACAACATCATGTCTCCGGTGCCACTTCTTTCAAAACACAAAAGCA
AAAAAGGTCAAGCCTCCTCTCCAAGTCACGTCACTAGGAATGGTGAGGTTGTGGAGGCCTGGTATGGCTCTGATGAATACCTAGCACTGC
CCTCTCACCTTAAGCAGACAGAAGTATTGGCTTTGAAGTTGGAAAACCTAACAAAGCTTCTGCCTCAGAAACCCAGAGGAGAAACCATCC
AGAATATTGATGACTGGGAACTGTCTGAAATGAATTCAGATTCTGAAATCTATCCAACCTATCATGTCAAAAAGAAGCATACAAGGCTAG
GCAGGGTGTCTCCAAGCTCATCTAGTGACATAGCCTCTTCACTAGGGGAGAGCATTGAATCTGGGCCCCTGAGTGACATTCTTTCTGATG
AGGAGTCCAGTATGCCTCTCGCTGGCATGAAAAAGTATGCTGATGAGAAGTCAGAAAGAGCTTCATCCTCTGAGAAAAATGAGAGCCATT
CTGCCACTAAATCAGCTTTAATTCAGAAACTGATGCAAGATATTCAGCACCAAGACAACTATGAAGCCATATGGGAAAAAATAGAGGGGT
TTGTAAACAAACTGGATGAATTCATTCAATGGTTAAATGAAGCCATGGAAACTACAGAAAATTGGACTCCCCCTAAAGCAGAGATGGATG
ACCTTAAACTGTATCTGGAGACACACTTGAGTTTTAAGTTGAATGTAGACAGTCATTGTGCTCTCAAGGAAGCTGTGGAGGAGGAAGGAC
ACCAACTTCTTGAGCTTATTGCATCTCACAAAGCAGGACTGAAGGACATGCTGCGGATGATTGCAAGTCAATGGAAGGAGCTGCAGAGGC
AAATCAAACGGCAGCACAGCTGGATTCTCAGGGCTCTGGATACCATCAAAGCCGAGATACTGGCTACTGATGTGTCTGTGGAGGATGAGG
AAGGGACTGGAAGCCCCAAGGACATCAGCACAGTATATCAGATTTTTCCTGATGAAGTACTGGGTTCTGGACAGTTTGGAATTGTTTATG
GAGGAAAACATCGTAAAACAGGAAGAGATGTAGCTATTAAAATCATTGACAAATTACGATTTCCAACAAAACAAGAAAGCCAGCTTCGTA
ATGAGGTTGCAATTCTACAGAACCTTCATCACCCTGGTGTTGTAAATTTGGAGTGTATGTTTGAGACGCCTGAAAGAGTGTTTGTTGTTA
TGGAAAAACTCCATGGAGACATGCTGGAAATGATCTTGTCAAGTGAAAAGGGCAGGTTGCCAGAGCACATAACGAAGTTTTTAATTACTC
AGATACTCGTGGCTTTGCGGCACCTTCATTTTAAAAATATCGTTCACTGTGACCTCAAACCAGAAAATGTGTTGCTAGCCTCAGCTGATC
CTTTTCCTCAGGTGAAACTTTGTGATTTTGGTTTTGCCCGGATCATTGGAGAGAAGTCTTTCCGGAGGTCAGTGGTGGGTACCCCCGCTT
ACCTGGCTCCTGAGGTCCTAAGGAACAAGGGCTACAATCGCTCTCTAGACATGTGGTCTGTTGGGGTCATCATCTATGTAAGCCTAAGCG
GCACATTCCCATTTAATGAAGATGAAGACATACACGACCAAATTCAGAATGCAGCTTTCATGTATCCACCAAATCCCTGGAAGGAAATAT
CTCATGAAGCCATTGATCTTATCAACAATTTGCTGCAAGTAAAAATGAGAAAGCGCTACAGTGTGGATAAGACCTTGAGCCACCCTTGGC
TACAGGACTATCAGACCTGGTTAGATTTGCGAGAGCTGGAATGCAAAATCGGGGAGCGCTACATCACCCATGAAAGTGATGACCTGAGGT
GGGAGAAGTATGCAGGCGAGCAGGGGCTGCAGTACCCCACACACCTGATCAATCCAAGTGCTAGCCACAGTGACACTCCTGAGACTGAAG
AAACAGAAATGAAAGCCCTCGGTGAGCGTGTCAGCATCCTCTGAGTTCCATCTCCTATAATCTGTCAAAACACTGTGGAACTAATAAATA
CATACGGTCAGGTTTAACATTTGCCTTGCAGAACTGCCATTATTTTCTGTCAGATGAGAACAAAGCTGTTAAACTGTTAGCACTGTTGAT
GTATCTGAGTTGCCAAGACAAATCAACAGAAGCATTTGTATTTTGTGTGACCAACTGTGTTGTATTAACAAAAGTTCCCTGAAACACGAA

>3353_3353_2_AKAP6-PRKD1_AKAP6_chr14_33069998_ENST00000280979_PRKD1_chr14_30095762_ENST00000415220_length(amino acids)=1247AA_BP=910
MLTMSVTLSPLRSQDLDPMATDASPMAINMTPTVEQGEGEEAMKDMDSDQQYEKPPPLHTGADWKIVLHLPEIETWLRMTSERVRDLTYS
VQQDSDSKHVDVHLVQLKDICEDISDHVEQIHALLETEFSLKLLSYSVNVIVDIHAVQLLWHQLRVSVLVLRERILQGLQDANGNYTRQT
DILQAFSEETKEGRLDSLTEVDDSGQLTIKCSQNYLSLDCGITAFELSDYSPSEDLLSGLGDMTSSQVKTKPFDSWSYSEMEKEFPELIR
SVGLLTVAADSISTNGSEAVTEEVSQVSLSVDDKGGCEEDNASAVEEQPGLTLGVSSSSGEALTNAAQPSSETVQQESSSSSHHDAKNQQ
PVPCENATPKRTIRDCFNYNEDSPTQPTLPKRGLFLKEETFKNDLKGNGGKRQMVDLKPEMSRSTPSLVDPPDRSKLCLVLQSSYPNSPS
AASQSYECLHKVGNGNLENTVKFHIKEISSSLGRLNDCYKEKSRLKKPHKTSEEVPPCRTPKRGTGSGKQAKNTKSSAVPNGELSYTSKA
IEGPQTNSASTSSLEPCNQRSWNAKLQLQSETSSSPAFTQSSESSVGSDNIMSPVPLLSKHKSKKGQASSPSHVTRNGEVVEAWYGSDEY
LALPSHLKQTEVLALKLENLTKLLPQKPRGETIQNIDDWELSEMNSDSEIYPTYHVKKKHTRLGRVSPSSSSDIASSLGESIESGPLSDI
LSDEESSMPLAGMKKYADEKSERASSSEKNESHSATKSALIQKLMQDIQHQDNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKA
EMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRALDTIKAEILATDVSV
EDEEGTGSPKDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERV
FVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVG
TPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLS

--------------------------------------------------------------
>3353_3353_3_AKAP6-PRKD1_AKAP6_chr14_33069998_ENST00000557272_PRKD1_chr14_30095762_ENST00000331968_length(transcript)=4544nt_BP=2773nt
CAGGAGATGCTGTTTTGGAAAGAAGTGAGGTTTAGACTTCTCCATGTTAACCATGAGCGTGACACTTTCCCCCCTGAGGTCACAGGACCT
GGATCCCATGGCTACTGATGCTTCACCCATGGCCATCAACATGACACCCACTGTGGAGCAGGGTGAGGGAGAAGAGGCAATGAAGGACAT
GGACTCTGACCAGCAGTATGAAAAGCCACCCCCACTACACACAGGGGCTGACTGGAAGATTGTCCTCCACTTACCTGAAATTGAGACCTG
GCTCCGGATGACCTCAGAGAGGGTCCGAGACCTAACCTATTCAGTCCAGCAGGATTCGGACAGCAAGCATGTGGATGTACATCTAGTTCA
ACTAAAGGACATTTGTGAAGATATTTCTGATCATGTTGAGCAAATCCATGCCCTCCTTGAAACAGAGTTCTCCCTAAAGCTGCTGTCTTA
CTCTGTCAACGTGATAGTGGACATCCACGCAGTGCAGCTCCTCTGGCACCAGCTTCGAGTCTCAGTGCTGGTTCTGCGGGAGCGCATTCT
GCAAGGTCTGCAGGACGCCAATGGCAACTACACTAGGCAGACGGACATTCTGCAAGCTTTCTCTGAAGAGACAAAAGAGGGCCGGCTTGA
TTCTCTAACAGAAGTGGATGACTCAGGACAATTAACCATCAAATGTTCTCAAAATTACTTGTCTCTGGATTGTGGCATTACTGCATTCGA
ACTGTCTGACTACAGTCCAAGTGAGGATTTGCTCAGTGGGCTAGGTGACATGACCTCTAGCCAAGTCAAAACCAAACCCTTTGACTCTTG
GAGCTACAGTGAGATGGAAAAGGAGTTTCCTGAGCTTATCCGAAGTGTTGGTTTACTTACGGTAGCTGCTGACTCTATCTCTACCAATGG
CAGTGAAGCAGTTACTGAGGAGGTATCTCAAGTATCTCTCTCAGTAGACGACAAAGGTGGATGTGAGGAAGACAATGCTTCTGCAGTCGA
AGAGCAACCAGGCTTAACACTGGGGGTGTCATCATCTTCAGGAGAAGCTCTGACAAATGCTGCTCAACCCTCCTCTGAGACTGTGCAGCA
AGAATCCAGTTCCTCCTCCCATCATGATGCAAAGAATCAGCAGCCTGTTCCTTGTGAAAATGCAACCCCCAAACGAACCATCAGAGATTG
CTTTAATTATAACGAGGACTCTCCCACGCAGCCTACATTGCCAAAAAGAGGACTTTTTCTTAAAGAGGAAACTTTTAAGAATGATCTGAA
AGGCAATGGTGGAAAGAGGCAAATGGTTGATCTAAAGCCTGAGATGAGCAGAAGCACCCCTTCGCTAGTAGATCCTCCTGACAGATCCAA
ACTTTGCCTGGTATTGCAGTCTTCTTACCCCAACAGCCCTTCTGCTGCCAGCCAGTCTTATGAGTGTTTACACAAGGTGGGGAATGGGAA
CCTTGAAAACACAGTCAAATTTCACATTAAAGAAATTTCTTCCAGCCTGGGAAGGCTTAACGACTGCTATAAAGAGAAATCTCGACTTAA
AAAGCCACACAAGACCTCAGAAGAGGTGCCTCCATGCCGAACACCTAAACGGGGGACTGGTTCAGGCAAACAAGCTAAAAATACAAAGAG
CTCAGCAGTGCCAAATGGAGAGCTTTCTTATACTTCCAAGGCCATAGAGGGGCCACAAACAAATTCTGCTTCCACATCCTCACTTGAGCC
TTGTAATCAGAGAAGTTGGAATGCCAAATTGCAATTGCAGTCAGAAACATCCAGTTCACCAGCTTTTACTCAGAGCAGTGAATCCTCTGT
TGGCTCAGACAACATCATGTCTCCGGTGCCACTTCTTTCAAAACACAAAAGCAAAAAAGGTCAAGCCTCCTCTCCAAGTCACGTCACTAG
GAATGGTGAGGTTGTGGAGGCCTGGTATGGCTCTGATGAATACCTAGCACTGCCCTCTCACCTTAAGCAGACAGAAGTATTGGCTTTGAA
GTTGGAAAACCTAACAAAGCTTCTGCCTCAGAAACCCAGAGGAGAAACCATCCAGAATATTGATGACTGGGAACTGTCTGAAATGAATTC
AGATTCTGAAATCTATCCAACCTATCATGTCAAAAAGAAGCATACAAGGCTAGGCAGGGTGTCTCCAAGCTCATCTAGTGACATAGCCTC
TTCACTAGGGGAGAGCATTGAATCTGGGCCCCTGAGTGACATTCTTTCTGATGAGGAGTCCAGTATGCCTCTCGCTGGCATGAAAAAGTA
TGCTGATGAGAAGTCAGAAAGAGCTTCATCCTCTGAGAAAAATGAGAGCCATTCTGCCACTAAATCAGCTTTAATTCAGAAACTGATGCA
AGATATTCAGCACCAAGACAACTATGAAGCCATATGGGAAAAAATAGAGGGGTTTGTAAACAAACTGGATGAATTCATTCAATGGTTAAA
TGAAGCCATGGAAACTACAGAAAATTGGACTCCCCCTAAAGCAGAGATGGATGACCTTAAACTGTATCTGGAGACACACTTGAGTTTTAA
GTTGAATGTAGACAGTCATTGTGCTCTCAAGGAAGCTGTGGAGGAGGAAGGACACCAACTTCTTGAGCTTATTGCATCTCACAAAGCAGG
ACTGAAGGACATGCTGCGGATGATTGCAAGTCAATGGAAGGAGCTGCAGAGGCAAATCAAACGGCAGCACAGCTGGATTCTCAGGGCTCT
GGATACCATCAAAGCCGAGATACTGGCTACTGATGTGTCTGTGGAGGATGAGGAAGGGACTGGAAGCCCCAAGGACATCAGCACAGTATA
TCAGATTTTTCCTGATGAAGTACTGGGTTCTGGACAGTTTGGAATTGTTTATGGAGGAAAACATCGTAAAACAGGAAGAGATGTAGCTAT
TAAAATCATTGACAAATTACGATTTCCAACAAAACAAGAAAGCCAGCTTCGTAATGAGGTTGCAATTCTACAGAACCTTCATCACCCTGG
TGTTGTAAATTTGGAGTGTATGTTTGAGACGCCTGAAAGAGTGTTTGTTGTTATGGAAAAACTCCATGGAGACATGCTGGAAATGATCTT
GTCAAGTGAAAAGGGCAGGTTGCCAGAGCACATAACGAAGTTTTTAATTACTCAGATACTCGTGGCTTTGCGGCACCTTCATTTTAAAAA
TATCGTTCACTGTGACCTCAAACCAGAAAATGTGTTGCTAGCCTCAGCTGATCCTTTTCCTCAGGTGAAACTTTGTGATTTTGGTTTTGC
CCGGATCATTGGAGAGAAGTCTTTCCGGAGGTCAGTGGTGGGTACCCCCGCTTACCTGGCTCCTGAGGTCCTAAGGAACAAGGGCTACAA
TCGCTCTCTAGACATGTGGTCTGTTGGGGTCATCATCTATGTAAGCCTAAGCGGCACATTCCCATTTAATGAAGATGAAGACATACACGA
CCAAATTCAGAATGCAGCTTTCATGTATCCACCAAATCCCTGGAAGGAAATATCTCATGAAGCCATTGATCTTATCAACAATTTGCTGCA
AGTAAAAATGAGAAAGCGCTACAGTGTGGATAAGACCTTGAGCCACCCTTGGCTACAGGACTATCAGACCTGGTTAGATTTGCGAGAGCT
GGAATGCAAAATCGGGGAGCGCTACATCACCCATGAAAGTGATGACCTGAGGTGGGAGAAGTATGCAGGCGAGCAGGGGCTGCAGTACCC
CACACACCTGATCAATCCAAGTGCTAGCCACAGTGACACTCCTGAGACTGAAGAAACAGAAATGAAAGCCCTCGGTGAGCGTGTCAGCAT
CCTCTGAGTTCCATCTCCTATAATCTGTCAAAACACTGTGGAACTAATAAATACATACGGTCAGGTTTAACATTTGCCTTGCAGAACTGC
CATTATTTTCTGTCAGATGAGAACAAAGCTGTTAAACTGTTAGCACTGTTGATGTATCTGAGTTGCCAAGACAAATCAACAGAAGCATTT
GTATTTTGTGTGACCAACTGTGTTGTATTAACAAAAGTTCCCTGAAACACGAAACTTGTTATTGTGAATGATTCATGTTATATTTAATGC
ATTAAACCTGTCTCCACTGTGCCTTTGCAAATCAGTGTTTTTCTTACTGGAGCTTCATTTTGGTAAGAGACAGAATGTATCTGTGAAGTA
GTTCTGTTTGGTGTGTCCCATTGGTGTTGTCATTGTAAACAAACTCTTGAAGAGTCGATTATTTCCAGTGTTCTATGAACAACTCCAAAA
CCCATGTGGGAAAAAAATGAATGAGGAGGGTAGGGAATAAAATCCTAAGACACAAATGCATGAACAAGTTTTAATGTATAGTTTTGAATC
CTTTGCCTGCCTGGTGTGCCTCAGTATATTTAAACTCAAGACAATGCACCTAGCTGTGCAAGACCTAGTGCTCTTAAGCCTAAATGCCTT
AGAAATGTAAACTGCCATATATAACAGATACATTTCCCTCTTTCTTATAATACTCTGTTGTACTATGGAAAATCAGCTGCTCAGCAACCT

>3353_3353_3_AKAP6-PRKD1_AKAP6_chr14_33069998_ENST00000557272_PRKD1_chr14_30095762_ENST00000331968_length(amino acids)=1247AA_BP=910
MLTMSVTLSPLRSQDLDPMATDASPMAINMTPTVEQGEGEEAMKDMDSDQQYEKPPPLHTGADWKIVLHLPEIETWLRMTSERVRDLTYS
VQQDSDSKHVDVHLVQLKDICEDISDHVEQIHALLETEFSLKLLSYSVNVIVDIHAVQLLWHQLRVSVLVLRERILQGLQDANGNYTRQT
DILQAFSEETKEGRLDSLTEVDDSGQLTIKCSQNYLSLDCGITAFELSDYSPSEDLLSGLGDMTSSQVKTKPFDSWSYSEMEKEFPELIR
SVGLLTVAADSISTNGSEAVTEEVSQVSLSVDDKGGCEEDNASAVEEQPGLTLGVSSSSGEALTNAAQPSSETVQQESSSSSHHDAKNQQ
PVPCENATPKRTIRDCFNYNEDSPTQPTLPKRGLFLKEETFKNDLKGNGGKRQMVDLKPEMSRSTPSLVDPPDRSKLCLVLQSSYPNSPS
AASQSYECLHKVGNGNLENTVKFHIKEISSSLGRLNDCYKEKSRLKKPHKTSEEVPPCRTPKRGTGSGKQAKNTKSSAVPNGELSYTSKA
IEGPQTNSASTSSLEPCNQRSWNAKLQLQSETSSSPAFTQSSESSVGSDNIMSPVPLLSKHKSKKGQASSPSHVTRNGEVVEAWYGSDEY
LALPSHLKQTEVLALKLENLTKLLPQKPRGETIQNIDDWELSEMNSDSEIYPTYHVKKKHTRLGRVSPSSSSDIASSLGESIESGPLSDI
LSDEESSMPLAGMKKYADEKSERASSSEKNESHSATKSALIQKLMQDIQHQDNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKA
EMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRALDTIKAEILATDVSV
EDEEGTGSPKDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERV
FVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVG
TPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLS

--------------------------------------------------------------
>3353_3353_4_AKAP6-PRKD1_AKAP6_chr14_33069998_ENST00000557272_PRKD1_chr14_30095762_ENST00000415220_length(transcript)=4083nt_BP=2773nt
CAGGAGATGCTGTTTTGGAAAGAAGTGAGGTTTAGACTTCTCCATGTTAACCATGAGCGTGACACTTTCCCCCCTGAGGTCACAGGACCT
GGATCCCATGGCTACTGATGCTTCACCCATGGCCATCAACATGACACCCACTGTGGAGCAGGGTGAGGGAGAAGAGGCAATGAAGGACAT
GGACTCTGACCAGCAGTATGAAAAGCCACCCCCACTACACACAGGGGCTGACTGGAAGATTGTCCTCCACTTACCTGAAATTGAGACCTG
GCTCCGGATGACCTCAGAGAGGGTCCGAGACCTAACCTATTCAGTCCAGCAGGATTCGGACAGCAAGCATGTGGATGTACATCTAGTTCA
ACTAAAGGACATTTGTGAAGATATTTCTGATCATGTTGAGCAAATCCATGCCCTCCTTGAAACAGAGTTCTCCCTAAAGCTGCTGTCTTA
CTCTGTCAACGTGATAGTGGACATCCACGCAGTGCAGCTCCTCTGGCACCAGCTTCGAGTCTCAGTGCTGGTTCTGCGGGAGCGCATTCT
GCAAGGTCTGCAGGACGCCAATGGCAACTACACTAGGCAGACGGACATTCTGCAAGCTTTCTCTGAAGAGACAAAAGAGGGCCGGCTTGA
TTCTCTAACAGAAGTGGATGACTCAGGACAATTAACCATCAAATGTTCTCAAAATTACTTGTCTCTGGATTGTGGCATTACTGCATTCGA
ACTGTCTGACTACAGTCCAAGTGAGGATTTGCTCAGTGGGCTAGGTGACATGACCTCTAGCCAAGTCAAAACCAAACCCTTTGACTCTTG
GAGCTACAGTGAGATGGAAAAGGAGTTTCCTGAGCTTATCCGAAGTGTTGGTTTACTTACGGTAGCTGCTGACTCTATCTCTACCAATGG
CAGTGAAGCAGTTACTGAGGAGGTATCTCAAGTATCTCTCTCAGTAGACGACAAAGGTGGATGTGAGGAAGACAATGCTTCTGCAGTCGA
AGAGCAACCAGGCTTAACACTGGGGGTGTCATCATCTTCAGGAGAAGCTCTGACAAATGCTGCTCAACCCTCCTCTGAGACTGTGCAGCA
AGAATCCAGTTCCTCCTCCCATCATGATGCAAAGAATCAGCAGCCTGTTCCTTGTGAAAATGCAACCCCCAAACGAACCATCAGAGATTG
CTTTAATTATAACGAGGACTCTCCCACGCAGCCTACATTGCCAAAAAGAGGACTTTTTCTTAAAGAGGAAACTTTTAAGAATGATCTGAA
AGGCAATGGTGGAAAGAGGCAAATGGTTGATCTAAAGCCTGAGATGAGCAGAAGCACCCCTTCGCTAGTAGATCCTCCTGACAGATCCAA
ACTTTGCCTGGTATTGCAGTCTTCTTACCCCAACAGCCCTTCTGCTGCCAGCCAGTCTTATGAGTGTTTACACAAGGTGGGGAATGGGAA
CCTTGAAAACACAGTCAAATTTCACATTAAAGAAATTTCTTCCAGCCTGGGAAGGCTTAACGACTGCTATAAAGAGAAATCTCGACTTAA
AAAGCCACACAAGACCTCAGAAGAGGTGCCTCCATGCCGAACACCTAAACGGGGGACTGGTTCAGGCAAACAAGCTAAAAATACAAAGAG
CTCAGCAGTGCCAAATGGAGAGCTTTCTTATACTTCCAAGGCCATAGAGGGGCCACAAACAAATTCTGCTTCCACATCCTCACTTGAGCC
TTGTAATCAGAGAAGTTGGAATGCCAAATTGCAATTGCAGTCAGAAACATCCAGTTCACCAGCTTTTACTCAGAGCAGTGAATCCTCTGT
TGGCTCAGACAACATCATGTCTCCGGTGCCACTTCTTTCAAAACACAAAAGCAAAAAAGGTCAAGCCTCCTCTCCAAGTCACGTCACTAG
GAATGGTGAGGTTGTGGAGGCCTGGTATGGCTCTGATGAATACCTAGCACTGCCCTCTCACCTTAAGCAGACAGAAGTATTGGCTTTGAA
GTTGGAAAACCTAACAAAGCTTCTGCCTCAGAAACCCAGAGGAGAAACCATCCAGAATATTGATGACTGGGAACTGTCTGAAATGAATTC
AGATTCTGAAATCTATCCAACCTATCATGTCAAAAAGAAGCATACAAGGCTAGGCAGGGTGTCTCCAAGCTCATCTAGTGACATAGCCTC
TTCACTAGGGGAGAGCATTGAATCTGGGCCCCTGAGTGACATTCTTTCTGATGAGGAGTCCAGTATGCCTCTCGCTGGCATGAAAAAGTA
TGCTGATGAGAAGTCAGAAAGAGCTTCATCCTCTGAGAAAAATGAGAGCCATTCTGCCACTAAATCAGCTTTAATTCAGAAACTGATGCA
AGATATTCAGCACCAAGACAACTATGAAGCCATATGGGAAAAAATAGAGGGGTTTGTAAACAAACTGGATGAATTCATTCAATGGTTAAA
TGAAGCCATGGAAACTACAGAAAATTGGACTCCCCCTAAAGCAGAGATGGATGACCTTAAACTGTATCTGGAGACACACTTGAGTTTTAA
GTTGAATGTAGACAGTCATTGTGCTCTCAAGGAAGCTGTGGAGGAGGAAGGACACCAACTTCTTGAGCTTATTGCATCTCACAAAGCAGG
ACTGAAGGACATGCTGCGGATGATTGCAAGTCAATGGAAGGAGCTGCAGAGGCAAATCAAACGGCAGCACAGCTGGATTCTCAGGGCTCT
GGATACCATCAAAGCCGAGATACTGGCTACTGATGTGTCTGTGGAGGATGAGGAAGGGACTGGAAGCCCCAAGGACATCAGCACAGTATA
TCAGATTTTTCCTGATGAAGTACTGGGTTCTGGACAGTTTGGAATTGTTTATGGAGGAAAACATCGTAAAACAGGAAGAGATGTAGCTAT
TAAAATCATTGACAAATTACGATTTCCAACAAAACAAGAAAGCCAGCTTCGTAATGAGGTTGCAATTCTACAGAACCTTCATCACCCTGG
TGTTGTAAATTTGGAGTGTATGTTTGAGACGCCTGAAAGAGTGTTTGTTGTTATGGAAAAACTCCATGGAGACATGCTGGAAATGATCTT
GTCAAGTGAAAAGGGCAGGTTGCCAGAGCACATAACGAAGTTTTTAATTACTCAGATACTCGTGGCTTTGCGGCACCTTCATTTTAAAAA
TATCGTTCACTGTGACCTCAAACCAGAAAATGTGTTGCTAGCCTCAGCTGATCCTTTTCCTCAGGTGAAACTTTGTGATTTTGGTTTTGC
CCGGATCATTGGAGAGAAGTCTTTCCGGAGGTCAGTGGTGGGTACCCCCGCTTACCTGGCTCCTGAGGTCCTAAGGAACAAGGGCTACAA
TCGCTCTCTAGACATGTGGTCTGTTGGGGTCATCATCTATGTAAGCCTAAGCGGCACATTCCCATTTAATGAAGATGAAGACATACACGA
CCAAATTCAGAATGCAGCTTTCATGTATCCACCAAATCCCTGGAAGGAAATATCTCATGAAGCCATTGATCTTATCAACAATTTGCTGCA
AGTAAAAATGAGAAAGCGCTACAGTGTGGATAAGACCTTGAGCCACCCTTGGCTACAGGACTATCAGACCTGGTTAGATTTGCGAGAGCT
GGAATGCAAAATCGGGGAGCGCTACATCACCCATGAAAGTGATGACCTGAGGTGGGAGAAGTATGCAGGCGAGCAGGGGCTGCAGTACCC
CACACACCTGATCAATCCAAGTGCTAGCCACAGTGACACTCCTGAGACTGAAGAAACAGAAATGAAAGCCCTCGGTGAGCGTGTCAGCAT
CCTCTGAGTTCCATCTCCTATAATCTGTCAAAACACTGTGGAACTAATAAATACATACGGTCAGGTTTAACATTTGCCTTGCAGAACTGC
CATTATTTTCTGTCAGATGAGAACAAAGCTGTTAAACTGTTAGCACTGTTGATGTATCTGAGTTGCCAAGACAAATCAACAGAAGCATTT
GTATTTTGTGTGACCAACTGTGTTGTATTAACAAAAGTTCCCTGAAACACGAAACTTGTTATTGTGAATGATTCATGTTATATTTAATGC

>3353_3353_4_AKAP6-PRKD1_AKAP6_chr14_33069998_ENST00000557272_PRKD1_chr14_30095762_ENST00000415220_length(amino acids)=1247AA_BP=910
MLTMSVTLSPLRSQDLDPMATDASPMAINMTPTVEQGEGEEAMKDMDSDQQYEKPPPLHTGADWKIVLHLPEIETWLRMTSERVRDLTYS
VQQDSDSKHVDVHLVQLKDICEDISDHVEQIHALLETEFSLKLLSYSVNVIVDIHAVQLLWHQLRVSVLVLRERILQGLQDANGNYTRQT
DILQAFSEETKEGRLDSLTEVDDSGQLTIKCSQNYLSLDCGITAFELSDYSPSEDLLSGLGDMTSSQVKTKPFDSWSYSEMEKEFPELIR
SVGLLTVAADSISTNGSEAVTEEVSQVSLSVDDKGGCEEDNASAVEEQPGLTLGVSSSSGEALTNAAQPSSETVQQESSSSSHHDAKNQQ
PVPCENATPKRTIRDCFNYNEDSPTQPTLPKRGLFLKEETFKNDLKGNGGKRQMVDLKPEMSRSTPSLVDPPDRSKLCLVLQSSYPNSPS
AASQSYECLHKVGNGNLENTVKFHIKEISSSLGRLNDCYKEKSRLKKPHKTSEEVPPCRTPKRGTGSGKQAKNTKSSAVPNGELSYTSKA
IEGPQTNSASTSSLEPCNQRSWNAKLQLQSETSSSPAFTQSSESSVGSDNIMSPVPLLSKHKSKKGQASSPSHVTRNGEVVEAWYGSDEY
LALPSHLKQTEVLALKLENLTKLLPQKPRGETIQNIDDWELSEMNSDSEIYPTYHVKKKHTRLGRVSPSSSSDIASSLGESIESGPLSDI
LSDEESSMPLAGMKKYADEKSERASSSEKNESHSATKSALIQKLMQDIQHQDNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKA
EMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRALDTIKAEILATDVSV
EDEEGTGSPKDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERV
FVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVG
TPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLS

--------------------------------------------------------------
>3353_3353_5_AKAP6-PRKD1_AKAP6_chr14_33069998_ENST00000557354_PRKD1_chr14_30095762_ENST00000331968_length(transcript)=4600nt_BP=2829nt
CTCCTAGTATTGCATCCTACAGATGTGCTGTAAACATCAAAAGAAGACGGTGGGATCAGGAGATGCTGTTTTGGAAAGAAGTGAGGTTTA
GACTTCTCCATGTTAACCATGAGCGTGACACTTTCCCCCCTGAGGTCACAGGACCTGGATCCCATGGCTACTGATGCTTCACCCATGGCC
ATCAACATGACACCCACTGTGGAGCAGGGTGAGGGAGAAGAGGCAATGAAGGACATGGACTCTGACCAGCAGTATGAAAAGCCACCCCCA
CTACACACAGGGGCTGACTGGAAGATTGTCCTCCACTTACCTGAAATTGAGACCTGGCTCCGGATGACCTCAGAGAGGGTCCGAGACCTA
ACCTATTCAGTCCAGCAGGATTCGGACAGCAAGCATGTGGATGTACATCTAGTTCAACTAAAGGACATTTGTGAAGATATTTCTGATCAT
GTTGAGCAAATCCATGCCCTCCTTGAAACAGAGTTCTCCCTAAAGCTGCTGTCTTACTCTGTCAACGTGATAGTGGACATCCACGCAGTG
CAGCTCCTCTGGCACCAGCTTCGAGTCTCAGTGCTGGTTCTGCGGGAGCGCATTCTGCAAGGTCTGCAGGACGCCAATGGCAACTACACT
AGGCAGACGGACATTCTGCAAGCTTTCTCTGAAGAGACAAAAGAGGGCCGGCTTGATTCTCTAACAGAAGTGGATGACTCAGGACAATTA
ACCATCAAATGTTCTCAAAATTACTTGTCTCTGGATTGTGGCATTACTGCATTCGAACTGTCTGACTACAGTCCAAGTGAGGATTTGCTC
AGTGGGCTAGGTGACATGACCTCTAGCCAAGTCAAAACCAAACCCTTTGACTCTTGGAGCTACAGTGAGATGGAAAAGGAGTTTCCTGAG
CTTATCCGAAGTGTTGGTTTACTTACGGTAGCTGCTGACTCTATCTCTACCAATGGCAGTGAAGCAGTTACTGAGGAGGTATCTCAAGTA
TCTCTCTCAGTAGACGACAAAGGTGGATGTGAGGAAGACAATGCTTCTGCAGTCGAAGAGCAACCAGGCTTAACACTGGGGGTGTCATCA
TCTTCAGGAGAAGCTCTGACAAATGCTGCTCAACCCTCCTCTGAGACTGTGCAGCAAGAATCCAGTTCCTCCTCCCATCATGATGCAAAG
AATCAGCAGCCTGTTCCTTGTGAAAATGCAACCCCCAAACGAACCATCAGAGATTGCTTTAATTATAACGAGGACTCTCCCACGCAGCCT
ACATTGCCAAAAAGAGGACTTTTTCTTAAAGAGGAAACTTTTAAGAATGATCTGAAAGGCAATGGTGGAAAGAGGCAAATGGTTGATCTA
AAGCCTGAGATGAGCAGAAGCACCCCTTCGCTAGTAGATCCTCCTGACAGATCCAAACTTTGCCTGGTATTGCAGTCTTCTTACCCCAAC
AGCCCTTCTGCTGCCAGCCAGTCTTATGAGTGTTTACACAAGGTGGGGAATGGGAACCTTGAAAACACAGTCAAATTTCACATTAAAGAA
ATTTCTTCCAGCCTGGGAAGGCTTAACGACTGCTATAAAGAGAAATCTCGACTTAAAAAGCCACACAAGACCTCAGAAGAGGTGCCTCCA
TGCCGAACACCTAAACGGGGGACTGGTTCAGGCAAACAAGCTAAAAATACAAAGAGCTCAGCAGTGCCAAATGGAGAGCTTTCTTATACT
TCCAAGGCCATAGAGGGGCCACAAACAAATTCTGCTTCCACATCCTCACTTGAGCCTTGTAATCAGAGAAGTTGGAATGCCAAATTGCAA
TTGCAGTCAGAAACATCCAGTTCACCAGCTTTTACTCAGAGCAGTGAATCCTCTGTTGGCTCAGACAACATCATGTCTCCGGTGCCACTT
CTTTCAAAACACAAAAGCAAAAAAGGTCAAGCCTCCTCTCCAAGTCACGTCACTAGGAATGGTGAGGTTGTGGAGGCCTGGTATGGCTCT
GATGAATACCTAGCACTGCCCTCTCACCTTAAGCAGACAGAAGTATTGGCTTTGAAGTTGGAAAACCTAACAAAGCTTCTGCCTCAGAAA
CCCAGAGGAGAAACCATCCAGAATATTGATGACTGGGAACTGTCTGAAATGAATTCAGATTCTGAAATCTATCCAACCTATCATGTCAAA
AAGAAGCATACAAGGCTAGGCAGGGTGTCTCCAAGCTCATCTAGTGACATAGCCTCTTCACTAGGGGAGAGCATTGAATCTGGGCCCCTG
AGTGACATTCTTTCTGATGAGGAGTCCAGTATGCCTCTCGCTGGCATGAAAAAGTATGCTGATGAGAAGTCAGAAAGAGCTTCATCCTCT
GAGAAAAATGAGAGCCATTCTGCCACTAAATCAGCTTTAATTCAGAAACTGATGCAAGATATTCAGCACCAAGACAACTATGAAGCCATA
TGGGAAAAAATAGAGGGGTTTGTAAACAAACTGGATGAATTCATTCAATGGTTAAATGAAGCCATGGAAACTACAGAAAATTGGACTCCC
CCTAAAGCAGAGATGGATGACCTTAAACTGTATCTGGAGACACACTTGAGTTTTAAGTTGAATGTAGACAGTCATTGTGCTCTCAAGGAA
GCTGTGGAGGAGGAAGGACACCAACTTCTTGAGCTTATTGCATCTCACAAAGCAGGACTGAAGGACATGCTGCGGATGATTGCAAGTCAA
TGGAAGGAGCTGCAGAGGCAAATCAAACGGCAGCACAGCTGGATTCTCAGGGCTCTGGATACCATCAAAGCCGAGATACTGGCTACTGAT
GTGTCTGTGGAGGATGAGGAAGGGACTGGAAGCCCCAAGGACATCAGCACAGTATATCAGATTTTTCCTGATGAAGTACTGGGTTCTGGA
CAGTTTGGAATTGTTTATGGAGGAAAACATCGTAAAACAGGAAGAGATGTAGCTATTAAAATCATTGACAAATTACGATTTCCAACAAAA
CAAGAAAGCCAGCTTCGTAATGAGGTTGCAATTCTACAGAACCTTCATCACCCTGGTGTTGTAAATTTGGAGTGTATGTTTGAGACGCCT
GAAAGAGTGTTTGTTGTTATGGAAAAACTCCATGGAGACATGCTGGAAATGATCTTGTCAAGTGAAAAGGGCAGGTTGCCAGAGCACATA
ACGAAGTTTTTAATTACTCAGATACTCGTGGCTTTGCGGCACCTTCATTTTAAAAATATCGTTCACTGTGACCTCAAACCAGAAAATGTG
TTGCTAGCCTCAGCTGATCCTTTTCCTCAGGTGAAACTTTGTGATTTTGGTTTTGCCCGGATCATTGGAGAGAAGTCTTTCCGGAGGTCA
GTGGTGGGTACCCCCGCTTACCTGGCTCCTGAGGTCCTAAGGAACAAGGGCTACAATCGCTCTCTAGACATGTGGTCTGTTGGGGTCATC
ATCTATGTAAGCCTAAGCGGCACATTCCCATTTAATGAAGATGAAGACATACACGACCAAATTCAGAATGCAGCTTTCATGTATCCACCA
AATCCCTGGAAGGAAATATCTCATGAAGCCATTGATCTTATCAACAATTTGCTGCAAGTAAAAATGAGAAAGCGCTACAGTGTGGATAAG
ACCTTGAGCCACCCTTGGCTACAGGACTATCAGACCTGGTTAGATTTGCGAGAGCTGGAATGCAAAATCGGGGAGCGCTACATCACCCAT
GAAAGTGATGACCTGAGGTGGGAGAAGTATGCAGGCGAGCAGGGGCTGCAGTACCCCACACACCTGATCAATCCAAGTGCTAGCCACAGT
GACACTCCTGAGACTGAAGAAACAGAAATGAAAGCCCTCGGTGAGCGTGTCAGCATCCTCTGAGTTCCATCTCCTATAATCTGTCAAAAC
ACTGTGGAACTAATAAATACATACGGTCAGGTTTAACATTTGCCTTGCAGAACTGCCATTATTTTCTGTCAGATGAGAACAAAGCTGTTA
AACTGTTAGCACTGTTGATGTATCTGAGTTGCCAAGACAAATCAACAGAAGCATTTGTATTTTGTGTGACCAACTGTGTTGTATTAACAA
AAGTTCCCTGAAACACGAAACTTGTTATTGTGAATGATTCATGTTATATTTAATGCATTAAACCTGTCTCCACTGTGCCTTTGCAAATCA
GTGTTTTTCTTACTGGAGCTTCATTTTGGTAAGAGACAGAATGTATCTGTGAAGTAGTTCTGTTTGGTGTGTCCCATTGGTGTTGTCATT
GTAAACAAACTCTTGAAGAGTCGATTATTTCCAGTGTTCTATGAACAACTCCAAAACCCATGTGGGAAAAAAATGAATGAGGAGGGTAGG
GAATAAAATCCTAAGACACAAATGCATGAACAAGTTTTAATGTATAGTTTTGAATCCTTTGCCTGCCTGGTGTGCCTCAGTATATTTAAA
CTCAAGACAATGCACCTAGCTGTGCAAGACCTAGTGCTCTTAAGCCTAAATGCCTTAGAAATGTAAACTGCCATATATAACAGATACATT
TCCCTCTTTCTTATAATACTCTGTTGTACTATGGAAAATCAGCTGCTCAGCAACCTTTCACCTTTGTGTATTTTTCAATAATAAAAAATA

>3353_3353_5_AKAP6-PRKD1_AKAP6_chr14_33069998_ENST00000557354_PRKD1_chr14_30095762_ENST00000331968_length(amino acids)=1247AA_BP=910
MLTMSVTLSPLRSQDLDPMATDASPMAINMTPTVEQGEGEEAMKDMDSDQQYEKPPPLHTGADWKIVLHLPEIETWLRMTSERVRDLTYS
VQQDSDSKHVDVHLVQLKDICEDISDHVEQIHALLETEFSLKLLSYSVNVIVDIHAVQLLWHQLRVSVLVLRERILQGLQDANGNYTRQT
DILQAFSEETKEGRLDSLTEVDDSGQLTIKCSQNYLSLDCGITAFELSDYSPSEDLLSGLGDMTSSQVKTKPFDSWSYSEMEKEFPELIR
SVGLLTVAADSISTNGSEAVTEEVSQVSLSVDDKGGCEEDNASAVEEQPGLTLGVSSSSGEALTNAAQPSSETVQQESSSSSHHDAKNQQ
PVPCENATPKRTIRDCFNYNEDSPTQPTLPKRGLFLKEETFKNDLKGNGGKRQMVDLKPEMSRSTPSLVDPPDRSKLCLVLQSSYPNSPS
AASQSYECLHKVGNGNLENTVKFHIKEISSSLGRLNDCYKEKSRLKKPHKTSEEVPPCRTPKRGTGSGKQAKNTKSSAVPNGELSYTSKA
IEGPQTNSASTSSLEPCNQRSWNAKLQLQSETSSSPAFTQSSESSVGSDNIMSPVPLLSKHKSKKGQASSPSHVTRNGEVVEAWYGSDEY
LALPSHLKQTEVLALKLENLTKLLPQKPRGETIQNIDDWELSEMNSDSEIYPTYHVKKKHTRLGRVSPSSSSDIASSLGESIESGPLSDI
LSDEESSMPLAGMKKYADEKSERASSSEKNESHSATKSALIQKLMQDIQHQDNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKA
EMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRALDTIKAEILATDVSV
EDEEGTGSPKDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERV
FVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVG
TPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLS

--------------------------------------------------------------
>3353_3353_6_AKAP6-PRKD1_AKAP6_chr14_33069998_ENST00000557354_PRKD1_chr14_30095762_ENST00000415220_length(transcript)=4139nt_BP=2829nt
CTCCTAGTATTGCATCCTACAGATGTGCTGTAAACATCAAAAGAAGACGGTGGGATCAGGAGATGCTGTTTTGGAAAGAAGTGAGGTTTA
GACTTCTCCATGTTAACCATGAGCGTGACACTTTCCCCCCTGAGGTCACAGGACCTGGATCCCATGGCTACTGATGCTTCACCCATGGCC
ATCAACATGACACCCACTGTGGAGCAGGGTGAGGGAGAAGAGGCAATGAAGGACATGGACTCTGACCAGCAGTATGAAAAGCCACCCCCA
CTACACACAGGGGCTGACTGGAAGATTGTCCTCCACTTACCTGAAATTGAGACCTGGCTCCGGATGACCTCAGAGAGGGTCCGAGACCTA
ACCTATTCAGTCCAGCAGGATTCGGACAGCAAGCATGTGGATGTACATCTAGTTCAACTAAAGGACATTTGTGAAGATATTTCTGATCAT
GTTGAGCAAATCCATGCCCTCCTTGAAACAGAGTTCTCCCTAAAGCTGCTGTCTTACTCTGTCAACGTGATAGTGGACATCCACGCAGTG
CAGCTCCTCTGGCACCAGCTTCGAGTCTCAGTGCTGGTTCTGCGGGAGCGCATTCTGCAAGGTCTGCAGGACGCCAATGGCAACTACACT
AGGCAGACGGACATTCTGCAAGCTTTCTCTGAAGAGACAAAAGAGGGCCGGCTTGATTCTCTAACAGAAGTGGATGACTCAGGACAATTA
ACCATCAAATGTTCTCAAAATTACTTGTCTCTGGATTGTGGCATTACTGCATTCGAACTGTCTGACTACAGTCCAAGTGAGGATTTGCTC
AGTGGGCTAGGTGACATGACCTCTAGCCAAGTCAAAACCAAACCCTTTGACTCTTGGAGCTACAGTGAGATGGAAAAGGAGTTTCCTGAG
CTTATCCGAAGTGTTGGTTTACTTACGGTAGCTGCTGACTCTATCTCTACCAATGGCAGTGAAGCAGTTACTGAGGAGGTATCTCAAGTA
TCTCTCTCAGTAGACGACAAAGGTGGATGTGAGGAAGACAATGCTTCTGCAGTCGAAGAGCAACCAGGCTTAACACTGGGGGTGTCATCA
TCTTCAGGAGAAGCTCTGACAAATGCTGCTCAACCCTCCTCTGAGACTGTGCAGCAAGAATCCAGTTCCTCCTCCCATCATGATGCAAAG
AATCAGCAGCCTGTTCCTTGTGAAAATGCAACCCCCAAACGAACCATCAGAGATTGCTTTAATTATAACGAGGACTCTCCCACGCAGCCT
ACATTGCCAAAAAGAGGACTTTTTCTTAAAGAGGAAACTTTTAAGAATGATCTGAAAGGCAATGGTGGAAAGAGGCAAATGGTTGATCTA
AAGCCTGAGATGAGCAGAAGCACCCCTTCGCTAGTAGATCCTCCTGACAGATCCAAACTTTGCCTGGTATTGCAGTCTTCTTACCCCAAC
AGCCCTTCTGCTGCCAGCCAGTCTTATGAGTGTTTACACAAGGTGGGGAATGGGAACCTTGAAAACACAGTCAAATTTCACATTAAAGAA
ATTTCTTCCAGCCTGGGAAGGCTTAACGACTGCTATAAAGAGAAATCTCGACTTAAAAAGCCACACAAGACCTCAGAAGAGGTGCCTCCA
TGCCGAACACCTAAACGGGGGACTGGTTCAGGCAAACAAGCTAAAAATACAAAGAGCTCAGCAGTGCCAAATGGAGAGCTTTCTTATACT
TCCAAGGCCATAGAGGGGCCACAAACAAATTCTGCTTCCACATCCTCACTTGAGCCTTGTAATCAGAGAAGTTGGAATGCCAAATTGCAA
TTGCAGTCAGAAACATCCAGTTCACCAGCTTTTACTCAGAGCAGTGAATCCTCTGTTGGCTCAGACAACATCATGTCTCCGGTGCCACTT
CTTTCAAAACACAAAAGCAAAAAAGGTCAAGCCTCCTCTCCAAGTCACGTCACTAGGAATGGTGAGGTTGTGGAGGCCTGGTATGGCTCT
GATGAATACCTAGCACTGCCCTCTCACCTTAAGCAGACAGAAGTATTGGCTTTGAAGTTGGAAAACCTAACAAAGCTTCTGCCTCAGAAA
CCCAGAGGAGAAACCATCCAGAATATTGATGACTGGGAACTGTCTGAAATGAATTCAGATTCTGAAATCTATCCAACCTATCATGTCAAA
AAGAAGCATACAAGGCTAGGCAGGGTGTCTCCAAGCTCATCTAGTGACATAGCCTCTTCACTAGGGGAGAGCATTGAATCTGGGCCCCTG
AGTGACATTCTTTCTGATGAGGAGTCCAGTATGCCTCTCGCTGGCATGAAAAAGTATGCTGATGAGAAGTCAGAAAGAGCTTCATCCTCT
GAGAAAAATGAGAGCCATTCTGCCACTAAATCAGCTTTAATTCAGAAACTGATGCAAGATATTCAGCACCAAGACAACTATGAAGCCATA
TGGGAAAAAATAGAGGGGTTTGTAAACAAACTGGATGAATTCATTCAATGGTTAAATGAAGCCATGGAAACTACAGAAAATTGGACTCCC
CCTAAAGCAGAGATGGATGACCTTAAACTGTATCTGGAGACACACTTGAGTTTTAAGTTGAATGTAGACAGTCATTGTGCTCTCAAGGAA
GCTGTGGAGGAGGAAGGACACCAACTTCTTGAGCTTATTGCATCTCACAAAGCAGGACTGAAGGACATGCTGCGGATGATTGCAAGTCAA
TGGAAGGAGCTGCAGAGGCAAATCAAACGGCAGCACAGCTGGATTCTCAGGGCTCTGGATACCATCAAAGCCGAGATACTGGCTACTGAT
GTGTCTGTGGAGGATGAGGAAGGGACTGGAAGCCCCAAGGACATCAGCACAGTATATCAGATTTTTCCTGATGAAGTACTGGGTTCTGGA
CAGTTTGGAATTGTTTATGGAGGAAAACATCGTAAAACAGGAAGAGATGTAGCTATTAAAATCATTGACAAATTACGATTTCCAACAAAA
CAAGAAAGCCAGCTTCGTAATGAGGTTGCAATTCTACAGAACCTTCATCACCCTGGTGTTGTAAATTTGGAGTGTATGTTTGAGACGCCT
GAAAGAGTGTTTGTTGTTATGGAAAAACTCCATGGAGACATGCTGGAAATGATCTTGTCAAGTGAAAAGGGCAGGTTGCCAGAGCACATA
ACGAAGTTTTTAATTACTCAGATACTCGTGGCTTTGCGGCACCTTCATTTTAAAAATATCGTTCACTGTGACCTCAAACCAGAAAATGTG
TTGCTAGCCTCAGCTGATCCTTTTCCTCAGGTGAAACTTTGTGATTTTGGTTTTGCCCGGATCATTGGAGAGAAGTCTTTCCGGAGGTCA
GTGGTGGGTACCCCCGCTTACCTGGCTCCTGAGGTCCTAAGGAACAAGGGCTACAATCGCTCTCTAGACATGTGGTCTGTTGGGGTCATC
ATCTATGTAAGCCTAAGCGGCACATTCCCATTTAATGAAGATGAAGACATACACGACCAAATTCAGAATGCAGCTTTCATGTATCCACCA
AATCCCTGGAAGGAAATATCTCATGAAGCCATTGATCTTATCAACAATTTGCTGCAAGTAAAAATGAGAAAGCGCTACAGTGTGGATAAG
ACCTTGAGCCACCCTTGGCTACAGGACTATCAGACCTGGTTAGATTTGCGAGAGCTGGAATGCAAAATCGGGGAGCGCTACATCACCCAT
GAAAGTGATGACCTGAGGTGGGAGAAGTATGCAGGCGAGCAGGGGCTGCAGTACCCCACACACCTGATCAATCCAAGTGCTAGCCACAGT
GACACTCCTGAGACTGAAGAAACAGAAATGAAAGCCCTCGGTGAGCGTGTCAGCATCCTCTGAGTTCCATCTCCTATAATCTGTCAAAAC
ACTGTGGAACTAATAAATACATACGGTCAGGTTTAACATTTGCCTTGCAGAACTGCCATTATTTTCTGTCAGATGAGAACAAAGCTGTTA
AACTGTTAGCACTGTTGATGTATCTGAGTTGCCAAGACAAATCAACAGAAGCATTTGTATTTTGTGTGACCAACTGTGTTGTATTAACAA

>3353_3353_6_AKAP6-PRKD1_AKAP6_chr14_33069998_ENST00000557354_PRKD1_chr14_30095762_ENST00000415220_length(amino acids)=1247AA_BP=910
MLTMSVTLSPLRSQDLDPMATDASPMAINMTPTVEQGEGEEAMKDMDSDQQYEKPPPLHTGADWKIVLHLPEIETWLRMTSERVRDLTYS
VQQDSDSKHVDVHLVQLKDICEDISDHVEQIHALLETEFSLKLLSYSVNVIVDIHAVQLLWHQLRVSVLVLRERILQGLQDANGNYTRQT
DILQAFSEETKEGRLDSLTEVDDSGQLTIKCSQNYLSLDCGITAFELSDYSPSEDLLSGLGDMTSSQVKTKPFDSWSYSEMEKEFPELIR
SVGLLTVAADSISTNGSEAVTEEVSQVSLSVDDKGGCEEDNASAVEEQPGLTLGVSSSSGEALTNAAQPSSETVQQESSSSSHHDAKNQQ
PVPCENATPKRTIRDCFNYNEDSPTQPTLPKRGLFLKEETFKNDLKGNGGKRQMVDLKPEMSRSTPSLVDPPDRSKLCLVLQSSYPNSPS
AASQSYECLHKVGNGNLENTVKFHIKEISSSLGRLNDCYKEKSRLKKPHKTSEEVPPCRTPKRGTGSGKQAKNTKSSAVPNGELSYTSKA
IEGPQTNSASTSSLEPCNQRSWNAKLQLQSETSSSPAFTQSSESSVGSDNIMSPVPLLSKHKSKKGQASSPSHVTRNGEVVEAWYGSDEY
LALPSHLKQTEVLALKLENLTKLLPQKPRGETIQNIDDWELSEMNSDSEIYPTYHVKKKHTRLGRVSPSSSSDIASSLGESIESGPLSDI
LSDEESSMPLAGMKKYADEKSERASSSEKNESHSATKSALIQKLMQDIQHQDNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKA
EMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRALDTIKAEILATDVSV
EDEEGTGSPKDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERV
FVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVG
TPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AKAP6-PRKD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AKAP6-PRKD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AKAP6-PRKD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource