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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GNAI2-GNAI2 (FusionGDB2 ID:33558)

Fusion Gene Summary for GNAI2-GNAI2

check button Fusion gene summary
Fusion gene informationFusion gene name: GNAI2-GNAI2
Fusion gene ID: 33558
HgeneTgene
Gene symbol

GNAI2

GNAI2

Gene ID

2771

2771

Gene nameG protein subunit alpha i2G protein subunit alpha i2
SynonymsGIP|GNAI2B|H_LUCA15.1|H_LUCA16.1GIP|GNAI2B|H_LUCA15.1|H_LUCA16.1
Cytomap

3p21.31

3p21.31

Type of geneprotein-codingprotein-coding
Descriptionguanine nucleotide-binding protein G(i) subunit alpha-2GTP-binding regulatory protein Gi alpha-2 chainadenylate cyclase-inhibiting G alpha proteinguanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2guanine nucleotideguanine nucleotide-binding protein G(i) subunit alpha-2GTP-binding regulatory protein Gi alpha-2 chainadenylate cyclase-inhibiting G alpha proteinguanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2guanine nucleotide
Modification date2020031320200313
UniProtAcc

P04899

P04899

Ensembl transtripts involved in fusion geneENST00000491100, ENST00000266027, 
ENST00000313601, ENST00000422163, 
ENST00000536647, ENST00000440628, 
ENST00000451956, 		ENST00000422163, 
ENST00000266027, ENST00000313601, 
ENST00000491100, ENST00000536647, 
ENST00000440628, ENST00000451956, 
Fusion gene scores* DoF score9 X 8 X 4=2886 X 7 X 3=126
# samples 107
** MAII scorelog2(10/288*10)=-1.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GNAI2 [Title/Abstract] AND GNAI2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGNAI2(50296311)-GNAI2(50296245), # samples:1
GNAI2(50294232)-GNAI2(50293682), # samples:1
Anticipated loss of major functional domain due to fusion event.GNAI2-GNAI2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
GNAI2-GNAI2 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across GNAI2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GNAI2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABE840018GNAI2chr3

50296311

+GNAI2chr3

50296245

-
ChiTaRS5.0N/ABI051043GNAI2chr3

50294232

+GNAI2chr3

50293682

-


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Fusion Gene ORF analysis for GNAI2-GNAI2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000491100ENST00000422163GNAI2chr3

50294232

+GNAI2chr3

50293682

-
3UTR-3UTRENST00000266027ENST00000266027GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-3UTRENST00000266027ENST00000313601GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-3UTRENST00000266027ENST00000422163GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-3UTRENST00000266027ENST00000491100GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-3UTRENST00000266027ENST00000536647GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-3UTRENST00000313601ENST00000266027GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-3UTRENST00000313601ENST00000313601GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-3UTRENST00000313601ENST00000422163GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-3UTRENST00000313601ENST00000491100GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-3UTRENST00000313601ENST00000536647GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-3UTRENST00000422163ENST00000266027GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-3UTRENST00000422163ENST00000313601GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-3UTRENST00000422163ENST00000422163GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-3UTRENST00000422163ENST00000491100GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-3UTRENST00000422163ENST00000536647GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-3UTRENST00000491100ENST00000266027GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-3UTRENST00000491100ENST00000266027GNAI2chr3

50294232

+GNAI2chr3

50293682

-
3UTR-3UTRENST00000491100ENST00000313601GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-3UTRENST00000491100ENST00000313601GNAI2chr3

50294232

+GNAI2chr3

50293682

-
3UTR-3UTRENST00000491100ENST00000422163GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-3UTRENST00000491100ENST00000440628GNAI2chr3

50294232

+GNAI2chr3

50293682

-
3UTR-3UTRENST00000491100ENST00000451956GNAI2chr3

50294232

+GNAI2chr3

50293682

-
3UTR-3UTRENST00000491100ENST00000491100GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-3UTRENST00000491100ENST00000491100GNAI2chr3

50294232

+GNAI2chr3

50293682

-
3UTR-3UTRENST00000491100ENST00000536647GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-3UTRENST00000491100ENST00000536647GNAI2chr3

50294232

+GNAI2chr3

50293682

-
3UTR-3UTRENST00000536647ENST00000266027GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-3UTRENST00000536647ENST00000313601GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-3UTRENST00000536647ENST00000422163GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-3UTRENST00000536647ENST00000491100GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-3UTRENST00000536647ENST00000536647GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-intronENST00000266027ENST00000440628GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-intronENST00000266027ENST00000451956GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-intronENST00000313601ENST00000440628GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-intronENST00000313601ENST00000451956GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-intronENST00000422163ENST00000440628GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-intronENST00000422163ENST00000451956GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-intronENST00000491100ENST00000440628GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-intronENST00000491100ENST00000451956GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-intronENST00000536647ENST00000440628GNAI2chr3

50296311

+GNAI2chr3

50296245

-
3UTR-intronENST00000536647ENST00000451956GNAI2chr3

50296311

+GNAI2chr3

50296245

-
5CDS-3UTRENST00000266027ENST00000266027GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000266027ENST00000313601GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000266027ENST00000440628GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000266027ENST00000451956GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000266027ENST00000491100GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000266027ENST00000536647GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000313601ENST00000266027GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000313601ENST00000313601GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000313601ENST00000440628GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000313601ENST00000451956GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000313601ENST00000491100GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000313601ENST00000536647GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000422163ENST00000266027GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000422163ENST00000313601GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000422163ENST00000440628GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000422163ENST00000451956GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000422163ENST00000491100GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000422163ENST00000536647GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000440628ENST00000266027GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000440628ENST00000313601GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000440628ENST00000440628GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000440628ENST00000451956GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000440628ENST00000491100GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000440628ENST00000536647GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000451956ENST00000266027GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000451956ENST00000313601GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000451956ENST00000440628GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000451956ENST00000451956GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000451956ENST00000491100GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000451956ENST00000536647GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000536647ENST00000266027GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000536647ENST00000313601GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000536647ENST00000440628GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000536647ENST00000451956GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000536647ENST00000491100GNAI2chr3

50294232

+GNAI2chr3

50293682

-
5CDS-3UTRENST00000536647ENST00000536647GNAI2chr3

50294232

+GNAI2chr3

50293682

-
Frame-shiftENST00000266027ENST00000422163GNAI2chr3

50294232

+GNAI2chr3

50293682

-
Frame-shiftENST00000313601ENST00000422163GNAI2chr3

50294232

+GNAI2chr3

50293682

-
Frame-shiftENST00000422163ENST00000422163GNAI2chr3

50294232

+GNAI2chr3

50293682

-
Frame-shiftENST00000440628ENST00000422163GNAI2chr3

50294232

+GNAI2chr3

50293682

-
Frame-shiftENST00000451956ENST00000422163GNAI2chr3

50294232

+GNAI2chr3

50293682

-
Frame-shiftENST00000536647ENST00000422163GNAI2chr3

50294232

+GNAI2chr3

50293682

-
intron-3UTRENST00000440628ENST00000266027GNAI2chr3

50296311

+GNAI2chr3

50296245

-
intron-3UTRENST00000440628ENST00000313601GNAI2chr3

50296311

+GNAI2chr3

50296245

-
intron-3UTRENST00000440628ENST00000422163GNAI2chr3

50296311

+GNAI2chr3

50296245

-
intron-3UTRENST00000440628ENST00000491100GNAI2chr3

50296311

+GNAI2chr3

50296245

-
intron-3UTRENST00000440628ENST00000536647GNAI2chr3

50296311

+GNAI2chr3

50296245

-
intron-3UTRENST00000451956ENST00000266027GNAI2chr3

50296311

+GNAI2chr3

50296245

-
intron-3UTRENST00000451956ENST00000313601GNAI2chr3

50296311

+GNAI2chr3

50296245

-
intron-3UTRENST00000451956ENST00000422163GNAI2chr3

50296311

+GNAI2chr3

50296245

-
intron-3UTRENST00000451956ENST00000491100GNAI2chr3

50296311

+GNAI2chr3

50296245

-
intron-3UTRENST00000451956ENST00000536647GNAI2chr3

50296311

+GNAI2chr3

50296245

-
intron-intronENST00000440628ENST00000440628GNAI2chr3

50296311

+GNAI2chr3

50296245

-
intron-intronENST00000440628ENST00000451956GNAI2chr3

50296311

+GNAI2chr3

50296245

-
intron-intronENST00000451956ENST00000440628GNAI2chr3

50296311

+GNAI2chr3

50296245

-
intron-intronENST00000451956ENST00000451956GNAI2chr3

50296311

+GNAI2chr3

50296245

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for GNAI2-GNAI2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GNAI2-GNAI2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:50296311/:50296245)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GNAI2

P04899

GNAI2

P04899

FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. {ECO:0000269|PubMed:17635935}.; FUNCTION: [Isoform sGi2]: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool. {ECO:0000269|PubMed:17550964}.FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. {ECO:0000269|PubMed:17635935}.; FUNCTION: [Isoform sGi2]: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool. {ECO:0000269|PubMed:17550964}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for GNAI2-GNAI2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GNAI2-GNAI2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GNAI2-GNAI2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GNAI2-GNAI2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource