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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GNAI2-NT5DC2 (FusionGDB2 ID:33561)

Fusion Gene Summary for GNAI2-NT5DC2

check button Fusion gene summary
Fusion gene informationFusion gene name: GNAI2-NT5DC2
Fusion gene ID: 33561
HgeneTgene
Gene symbol

GNAI2

NT5DC2

Gene ID

2771

64943

Gene nameG protein subunit alpha i25'-nucleotidase domain containing 2
SynonymsGIP|GNAI2B|H_LUCA15.1|H_LUCA16.1-
Cytomap

3p21.31

3p21.1

Type of geneprotein-codingprotein-coding
Descriptionguanine nucleotide-binding protein G(i) subunit alpha-2GTP-binding regulatory protein Gi alpha-2 chainadenylate cyclase-inhibiting G alpha proteinguanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2guanine nucleotide5'-nucleotidase domain-containing protein 2
Modification date2020031320200313
UniProtAcc

P04899

.
Ensembl transtripts involved in fusion geneENST00000313601, ENST00000536647, 
ENST00000266027, ENST00000422163, 
ENST00000440628, ENST00000451956, 
ENST00000491100, 		ENST00000490681, 
ENST00000307076, ENST00000307092, 
ENST00000422318, ENST00000459839, 
Fusion gene scores* DoF score9 X 8 X 4=28810 X 8 X 7=560
# samples 1011
** MAII scorelog2(10/288*10)=-1.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/560*10)=-2.34792330342031
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GNAI2 [Title/Abstract] AND NT5DC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGNAI2(50273885)-NT5DC2(52563351), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across GNAI2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NT5DC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABY797642GNAI2chr3

50273885

+NT5DC2chr3

52563351

-


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Fusion Gene ORF analysis for GNAI2-NT5DC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000313601ENST00000490681GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
5UTR-3CDSENST00000536647ENST00000307076GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
5UTR-3CDSENST00000536647ENST00000307092GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
5UTR-3CDSENST00000536647ENST00000422318GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
5UTR-3CDSENST00000536647ENST00000459839GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
5UTR-5UTRENST00000536647ENST00000490681GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
In-frameENST00000313601ENST00000307076GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
In-frameENST00000313601ENST00000307092GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
In-frameENST00000313601ENST00000422318GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
In-frameENST00000313601ENST00000459839GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
intron-3CDSENST00000266027ENST00000307076GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
intron-3CDSENST00000266027ENST00000307092GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
intron-3CDSENST00000266027ENST00000422318GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
intron-3CDSENST00000266027ENST00000459839GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
intron-3CDSENST00000422163ENST00000307076GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
intron-3CDSENST00000422163ENST00000307092GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
intron-3CDSENST00000422163ENST00000422318GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
intron-3CDSENST00000422163ENST00000459839GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
intron-3CDSENST00000440628ENST00000307076GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
intron-3CDSENST00000440628ENST00000307092GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
intron-3CDSENST00000440628ENST00000422318GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
intron-3CDSENST00000440628ENST00000459839GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
intron-3CDSENST00000451956ENST00000307076GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
intron-3CDSENST00000451956ENST00000307092GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
intron-3CDSENST00000451956ENST00000422318GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
intron-3CDSENST00000451956ENST00000459839GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
intron-3CDSENST00000491100ENST00000307076GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
intron-3CDSENST00000491100ENST00000307092GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
intron-3CDSENST00000491100ENST00000422318GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
intron-3CDSENST00000491100ENST00000459839GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
intron-5UTRENST00000266027ENST00000490681GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
intron-5UTRENST00000422163ENST00000490681GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
intron-5UTRENST00000440628ENST00000490681GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
intron-5UTRENST00000451956ENST00000490681GNAI2chr3

50273885

+NT5DC2chr3

52563351

-
intron-5UTRENST00000491100ENST00000490681GNAI2chr3

50273885

+NT5DC2chr3

52563351

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000313601GNAI2chr350273885+ENST00000307092NT5DC2chr352563351-19695021411868575
ENST00000313601GNAI2chr350273885+ENST00000307076NT5DC2chr352563351-20275021411943600
ENST00000313601GNAI2chr350273885+ENST00000422318NT5DC2chr352563351-20255021411943600
ENST00000313601GNAI2chr350273885+ENST00000459839NT5DC2chr352563351-18695021411868575

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000313601ENST00000307092GNAI2chr350273885+NT5DC2chr352563351-0.0129694220.98703057
ENST00000313601ENST00000307076GNAI2chr350273885+NT5DC2chr352563351-0.0178660.98213404
ENST00000313601ENST00000422318GNAI2chr350273885+NT5DC2chr352563351-0.0176856460.98231435
ENST00000313601ENST00000459839GNAI2chr350273885+NT5DC2chr352563351-0.0132862270.9867137

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Fusion Genomic Features for GNAI2-NT5DC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GNAI2-NT5DC2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:50273885/chr3:52563351)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GNAI2

P04899

.
FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. {ECO:0000269|PubMed:17635935}.; FUNCTION: [Isoform sGi2]: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool. {ECO:0000269|PubMed:17550964}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGNAI2chr3:50273885chr3:52563351ENST00000266027+1932_3550640.6666666666666DomainG-alpha
HgeneGNAI2chr3:50273885chr3:52563351ENST00000313601+1932_35539518.0DomainG-alpha
HgeneGNAI2chr3:50273885chr3:52563351ENST00000451956+1932_3550368.3333333333333DomainG-alpha
HgeneGNAI2chr3:50273885chr3:52563351ENST00000266027+19176_1820640.6666666666666Nucleotide bindingGTP
HgeneGNAI2chr3:50273885chr3:52563351ENST00000266027+19201_2050640.6666666666666Nucleotide bindingGTP
HgeneGNAI2chr3:50273885chr3:52563351ENST00000266027+19270_2730640.6666666666666Nucleotide bindingGTP
HgeneGNAI2chr3:50273885chr3:52563351ENST00000266027+1940_470640.6666666666666Nucleotide bindingGTP
HgeneGNAI2chr3:50273885chr3:52563351ENST00000313601+19176_18239518.0Nucleotide bindingGTP
HgeneGNAI2chr3:50273885chr3:52563351ENST00000313601+19201_20539518.0Nucleotide bindingGTP
HgeneGNAI2chr3:50273885chr3:52563351ENST00000313601+19270_27339518.0Nucleotide bindingGTP
HgeneGNAI2chr3:50273885chr3:52563351ENST00000313601+1940_4739518.0Nucleotide bindingGTP
HgeneGNAI2chr3:50273885chr3:52563351ENST00000451956+19176_1820368.3333333333333Nucleotide bindingGTP
HgeneGNAI2chr3:50273885chr3:52563351ENST00000451956+19201_2050368.3333333333333Nucleotide bindingGTP
HgeneGNAI2chr3:50273885chr3:52563351ENST00000451956+19270_2730368.3333333333333Nucleotide bindingGTP
HgeneGNAI2chr3:50273885chr3:52563351ENST00000451956+1940_470368.3333333333333Nucleotide bindingGTP
HgeneGNAI2chr3:50273885chr3:52563351ENST00000266027+19174_1820640.6666666666666RegionG2 motif
HgeneGNAI2chr3:50273885chr3:52563351ENST00000266027+19197_2060640.6666666666666RegionG3 motif
HgeneGNAI2chr3:50273885chr3:52563351ENST00000266027+19266_2730640.6666666666666RegionG4 motif
HgeneGNAI2chr3:50273885chr3:52563351ENST00000266027+19325_3300640.6666666666666RegionG5 motif
HgeneGNAI2chr3:50273885chr3:52563351ENST00000266027+1935_480640.6666666666666RegionG1 motif
HgeneGNAI2chr3:50273885chr3:52563351ENST00000313601+19174_18239518.0RegionG2 motif
HgeneGNAI2chr3:50273885chr3:52563351ENST00000313601+19197_20639518.0RegionG3 motif
HgeneGNAI2chr3:50273885chr3:52563351ENST00000313601+19266_27339518.0RegionG4 motif
HgeneGNAI2chr3:50273885chr3:52563351ENST00000313601+19325_33039518.0RegionG5 motif
HgeneGNAI2chr3:50273885chr3:52563351ENST00000313601+1935_4839518.0RegionG1 motif
HgeneGNAI2chr3:50273885chr3:52563351ENST00000451956+19174_1820368.3333333333333RegionG2 motif
HgeneGNAI2chr3:50273885chr3:52563351ENST00000451956+19197_2060368.3333333333333RegionG3 motif
HgeneGNAI2chr3:50273885chr3:52563351ENST00000451956+19266_2730368.3333333333333RegionG4 motif
HgeneGNAI2chr3:50273885chr3:52563351ENST00000451956+19325_3300368.3333333333333RegionG5 motif
HgeneGNAI2chr3:50273885chr3:52563351ENST00000451956+1935_480368.3333333333333RegionG1 motif


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Fusion Gene Sequence for GNAI2-NT5DC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>33561_33561_1_GNAI2-NT5DC2_GNAI2_chr3_50273885_ENST00000313601_NT5DC2_chr3_52563351_ENST00000307076_length(transcript)=2027nt_BP=502nt
AGTGCCGGGTCCCGGGGTTTGGAACCACCCCTATTGCCTTTTCTCCGCGTGGCCCCGCCTGCAGCCCAGGCCCGAGCCTGGGCTGCGCCT
AACTTCCCCCTTCGCTCCGCCCTCGAGCCAATCAACAGCCTCTAATCTCCTCTGGCCCCGCCTGCAAGCCCGCCCCGGCCCAGTCACAGG
CTTGGTTCGCCCAGGCCCCACCCCCGGCCCGCCCCGCCGTCGGTGCGCGGCGGTAGGGAAGGCGCCTCCCGCAGTCGCTCGGAACTGCCG
ACCCGAGTGCTTCCCGCAGAGGGCTGGTGGTGGGAGCGGAGTGGGTCGGGCGGGGCCGAGCCGGGCCGTGGGCCGTGTGGGGGCCGGGCG
GCGGCCGGGCCGGCGGACGGCGGGATGGGCTGCACCGTGAGCGCCGAGGACAAGGCGGCGGCCGAGCGCTCTAAGATGATCGACAAGAAC
CTGCGGGAGGACGGAGAGAAGGCGGCGCGGGAGGTGAAGTTGCTGCTGTTGGACCTCCTGCCCCCCGAGGTCTGCAGTCTCCTGAACCCA
GCAGCCATCTACGCCAACAACGAGATCAGCCTGCGTGACGTTGAGGTCTACGGCTTTGACTACGACTACACCCTGGCCCAGTATGCAGAC
GCACTGCACCCCGAGATCTTCAGTACCGCCCGTGACATCCTGATCGAGCACTACAAGTACCCAGAAGGGATTCGGAAGTATGACTACAAC
CCCAGCTTTGCCATCCGTGGCCTCCACTATGACATTCAGAAGAGCCTTCTGATGAAGATTGACGCCTTCCACTACGTGCAGCTGGGGACA
GCCTACAGGGGCCTCCAGCCTGTGCCAGACGAGGAGGTGATTGAGCTGTATGGGGGTACCCAGCACATCCCACTATACCAGATGAGTGGC
TTCTATGGCAAGGGTCCCTCCATTAAGCAGTTCATGGACATCTTCTCGCTACCGGAGATGGCTCTGCTGTCCTGTGTGGTGGACTACTTT
CTGGGCCACAGCCTGGAGTTTGACCAAGCACATCTCTACAAGGACGTGACGGACGCCATCCGAGACGTGCATGTGAAGGGCCTCATGTAC
CAGTGGATCGAGCAGGACATGGAGAAGTACATCCTGAGAGGGGATGAGACGTTTGCTGTCCTGAGCCGCCTGGTGGCCCATGGGAAACAG
CTGTTCCTCATCACCAACAGTCCTTTCAGCTTCGTAGACAAGGGGATGCGGCACATGGTGGGTCCCGATTGGCGCCAGCTCTTCGATGTG
GTCATTGTCCAGGCAGACAAGCCCAGCTTCTTCACTGACCGGCGCAAGCCTTTCAGAAAACTCGATGAGAAGGGCTCACTTCAGTGGGAC
CGGATCACCCGCTTGGAAAAGGGCAAGATCTATCGGCAGGGAAACCTGTTTGACTTCTTACGCTTGACGGAATGGCGTGGCCCCCGCGTG
CTCTACTTCGGGGACCACCTCTATAGTGATCTGGCGGATCTCATGCTGCGGCACGGCTGGCGCACAGGCGCCATCATCCCCGAGCTGGAG
CGTGAGATCCGCATCATCAACACGGAGCAGTACATGCACTCGCTGACGTGGCAGCAGGCGCTCACGGGGCTGCTGGAGCGCATGCAGACC
TATCAGGACGCGGAGTCGAGGCAGGTGCTGGCTGCCTGGATGAAAGAGCGGCAGGAGCTGAGGTGCATCACCAAGGCCCTGTTCAATGCG
CAGTTCGGCAGCATCTTCCGCACCTTCCACAACCCCACCTACTTCTCAAGGCGCCTCGTGCGCTTCTCTGACCTCTACATGGCCTCCCTC
AGCTGCCTGCTCAACTACCGCGTGGACTTCACCTTCTACCCACGCCGTACGCCGCTGCAGCACGAGGCACCCCTCTGGATGGACCAGCTC
TGCACCGGCTGCATGAAGACCCCCTTCCTTGGTGACATGGCCCACATCCGCTGAGGGCACCTTTATTGTCTGGGACAGGCCCTCAGCCCC

>33561_33561_1_GNAI2-NT5DC2_GNAI2_chr3_50273885_ENST00000313601_NT5DC2_chr3_52563351_ENST00000307076_length(amino acids)=600AA_BP=116
MAPPASPPRPSHRLGSPRPHPRPAPPSVRGGREGASRSRSELPTRVLPAEGWWWERSGSGGAEPGRGPCGGRAAAGPADGGMGCTVSAED
KAAAERSKMIDKNLREDGEKAAREVKLLLLDLLPPEVCSLLNPAAIYANNEISLRDVEVYGFDYDYTLAQYADALHPEIFSTARDILIEH
YKYPEGIRKYDYNPSFAIRGLHYDIQKSLLMKIDAFHYVQLGTAYRGLQPVPDEEVIELYGGTQHIPLYQMSGFYGKGPSIKQFMDIFSL
PEMALLSCVVDYFLGHSLEFDQAHLYKDVTDAIRDVHVKGLMYQWIEQDMEKYILRGDETFAVLSRLVAHGKQLFLITNSPFSFVDKGMR
HMVGPDWRQLFDVVIVQADKPSFFTDRRKPFRKLDEKGSLQWDRITRLEKGKIYRQGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLR
HGWRTGAIIPELEREIRIINTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSR

--------------------------------------------------------------
>33561_33561_2_GNAI2-NT5DC2_GNAI2_chr3_50273885_ENST00000313601_NT5DC2_chr3_52563351_ENST00000307092_length(transcript)=1969nt_BP=502nt
AGTGCCGGGTCCCGGGGTTTGGAACCACCCCTATTGCCTTTTCTCCGCGTGGCCCCGCCTGCAGCCCAGGCCCGAGCCTGGGCTGCGCCT
AACTTCCCCCTTCGCTCCGCCCTCGAGCCAATCAACAGCCTCTAATCTCCTCTGGCCCCGCCTGCAAGCCCGCCCCGGCCCAGTCACAGG
CTTGGTTCGCCCAGGCCCCACCCCCGGCCCGCCCCGCCGTCGGTGCGCGGCGGTAGGGAAGGCGCCTCCCGCAGTCGCTCGGAACTGCCG
ACCCGAGTGCTTCCCGCAGAGGGCTGGTGGTGGGAGCGGAGTGGGTCGGGCGGGGCCGAGCCGGGCCGTGGGCCGTGTGGGGGCCGGGCG
GCGGCCGGGCCGGCGGACGGCGGGATGGGCTGCACCGTGAGCGCCGAGGACAAGGCGGCGGCCGAGCGCTCTAAGATGATCGACAAGAAC
CTGCGGGAGGACGGAGAGAAGGCGGCGCGGGAGGTGAAGTTGCTGCTGTTGGACCTCCTGCCCCCCGAGGTCTGCAGTCTCCTGAACCCA
GCAGCCATCTACGCCAACAACGAGATCAGCCTGCGTGACGTTGAGGTCTACGGCTTTGACTACGACTACACCCTGGCCCAGTATGCAGAC
GCACTGCACCCCGAGATCTTCAGTACCGCCCGTGACATCCTGATCGAGCACTACAAGAGCCTTCTGATGAAGATTGACGCCTTCCACTAC
GTGCAGCTGGGGACAGCCTACAGGGGCCTCCAGCCTGTGCCAGACGAGGAGGTGATTGAGCTGTATGGGGGTACCCAGCACATCCCACTA
TACCAGATGAGTGGCTTCTATGGCAAGGGTCCCTCCATTAAGCAGTTCATGGACATCTTCTCGCTACCGGAGATGGCTCTGCTGTCCTGT
GTGGTGGACTACTTTCTGGGCCACAGCCTGGAGTTTGACCAAGCACATCTCTACAAGGACGTGACGGACGCCATCCGAGACGTGCATGTG
AAGGGCCTCATGTACCAGTGGATCGAGCAGGACATGGAGAAGTACATCCTGAGAGGGGATGAGACGTTTGCTGTCCTGAGCCGCCTGGTG
GCCCATGGGAAACAGCTGTTCCTCATCACCAACAGTCCTTTCAGCTTCGTAGACAAGGGGATGCGGCACATGGTGGGTCCCGATTGGCGC
CAGCTCTTCGATGTGGTCATTGTCCAGGCAGACAAGCCCAGCTTCTTCACTGACCGGCGCAAGCCTTTCAGAAAACTCGATGAGAAGGGC
TCACTTCAGTGGGACCGGATCACCCGCTTGGAAAAGGGCAAGATCTATCGGCAGGGAAACCTGTTTGACTTCTTACGCTTGACGGAATGG
CGTGGCCCCCGCGTGCTCTACTTCGGGGACCACCTCTATAGTGATCTGGCGGATCTCATGCTGCGGCACGGCTGGCGCACAGGCGCCATC
ATCCCCGAGCTGGAGCGTGAGATCCGCATCATCAACACGGAGCAGTACATGCACTCGCTGACGTGGCAGCAGGCGCTCACGGGGCTGCTG
GAGCGCATGCAGACCTATCAGGACGCGGAGTCGAGGCAGGTGCTGGCTGCCTGGATGAAAGAGCGGCAGGAGCTGAGGTGCATCACCAAG
GCCCTGTTCAATGCGCAGTTCGGCAGCATCTTCCGCACCTTCCACAACCCCACCTACTTCTCAAGGCGCCTCGTGCGCTTCTCTGACCTC
TACATGGCCTCCCTCAGCTGCCTGCTCAACTACCGCGTGGACTTCACCTTCTACCCACGCCGTACGCCGCTGCAGCACGAGGCACCCCTC
TGGATGGACCAGCTCTGCACCGGCTGCATGAAGACCCCCTTCCTTGGTGACATGGCCCACATCCGCTGAGGGCACCTTTATTGTCTGGGA

>33561_33561_2_GNAI2-NT5DC2_GNAI2_chr3_50273885_ENST00000313601_NT5DC2_chr3_52563351_ENST00000307092_length(amino acids)=575AA_BP=116
MAPPASPPRPSHRLGSPRPHPRPAPPSVRGGREGASRSRSELPTRVLPAEGWWWERSGSGGAEPGRGPCGGRAAAGPADGGMGCTVSAED
KAAAERSKMIDKNLREDGEKAAREVKLLLLDLLPPEVCSLLNPAAIYANNEISLRDVEVYGFDYDYTLAQYADALHPEIFSTARDILIEH
YKSLLMKIDAFHYVQLGTAYRGLQPVPDEEVIELYGGTQHIPLYQMSGFYGKGPSIKQFMDIFSLPEMALLSCVVDYFLGHSLEFDQAHL
YKDVTDAIRDVHVKGLMYQWIEQDMEKYILRGDETFAVLSRLVAHGKQLFLITNSPFSFVDKGMRHMVGPDWRQLFDVVIVQADKPSFFT
DRRKPFRKLDEKGSLQWDRITRLEKGKIYRQGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRIINTEQYM
HSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLNYRVDFTF

--------------------------------------------------------------
>33561_33561_3_GNAI2-NT5DC2_GNAI2_chr3_50273885_ENST00000313601_NT5DC2_chr3_52563351_ENST00000422318_length(transcript)=2025nt_BP=502nt
AGTGCCGGGTCCCGGGGTTTGGAACCACCCCTATTGCCTTTTCTCCGCGTGGCCCCGCCTGCAGCCCAGGCCCGAGCCTGGGCTGCGCCT
AACTTCCCCCTTCGCTCCGCCCTCGAGCCAATCAACAGCCTCTAATCTCCTCTGGCCCCGCCTGCAAGCCCGCCCCGGCCCAGTCACAGG
CTTGGTTCGCCCAGGCCCCACCCCCGGCCCGCCCCGCCGTCGGTGCGCGGCGGTAGGGAAGGCGCCTCCCGCAGTCGCTCGGAACTGCCG
ACCCGAGTGCTTCCCGCAGAGGGCTGGTGGTGGGAGCGGAGTGGGTCGGGCGGGGCCGAGCCGGGCCGTGGGCCGTGTGGGGGCCGGGCG
GCGGCCGGGCCGGCGGACGGCGGGATGGGCTGCACCGTGAGCGCCGAGGACAAGGCGGCGGCCGAGCGCTCTAAGATGATCGACAAGAAC
CTGCGGGAGGACGGAGAGAAGGCGGCGCGGGAGGTGAAGTTGCTGCTGTTGGACCTCCTGCCCCCCGAGGTCTGCAGTCTCCTGAACCCA
GCAGCCATCTACGCCAACAACGAGATCAGCCTGCGTGACGTTGAGGTCTACGGCTTTGACTACGACTACACCCTGGCCCAGTATGCAGAC
GCACTGCACCCCGAGATCTTCAGTACCGCCCGTGACATCCTGATCGAGCACTACAAGTACCCAGAAGGGATTCGGAAGTATGACTACAAC
CCCAGCTTTGCCATCCGTGGCCTCCACTATGACATTCAGAAGAGCCTTCTGATGAAGATTGACGCCTTCCACTACGTGCAGCTGGGGACA
GCCTACAGGGGCCTCCAGCCTGTGCCAGACGAGGAGGTGATTGAGCTGTATGGGGGTACCCAGCACATCCCACTATACCAGATGAGTGGC
TTCTATGGCAAGGGTCCCTCCATTAAGCAGTTCATGGACATCTTCTCGCTACCGGAGATGGCTCTGCTGTCCTGTGTGGTGGACTACTTT
CTGGGCCACAGCCTGGAGTTTGACCAAGCACATCTCTACAAGGACGTGACGGACGCCATCCGAGACGTGCATGTGAAGGGCCTCATGTAC
CAGTGGATCGAGCAGGACATGGAGAAGTACATCCTGAGAGGGGATGAGACGTTTGCTGTCCTGAGCCGCCTGGTGGCCCATGGGAAACAG
CTGTTCCTCATCACCAACAGTCCTTTCAGCTTCGTAGACAAGGGGATGCGGCACATGGTGGGTCCCGATTGGCGCCAGCTCTTCGATGTG
GTCATTGTCCAGGCAGACAAGCCCAGCTTCTTCACTGACCGGCGCAAGCCTTTCAGAAAACTCGATGAGAAGGGCTCACTTCAGTGGGAC
CGGATCACCCGCTTGGAAAAGGGCAAGATCTATCGGCAGGGAAACCTGTTTGACTTCTTACGCTTGACGGAATGGCGTGGCCCCCGCGTG
CTCTACTTCGGGGACCACCTCTATAGTGATCTGGCGGATCTCATGCTGCGGCACGGCTGGCGCACAGGCGCCATCATCCCCGAGCTGGAG
CGTGAGATCCGCATCATCAACACGGAGCAGTACATGCACTCGCTGACGTGGCAGCAGGCGCTCACGGGGCTGCTGGAGCGCATGCAGACC
TATCAGGACGCGGAGTCGAGGCAGGTGCTGGCTGCCTGGATGAAAGAGCGGCAGGAGCTGAGGTGCATCACCAAGGCCCTGTTCAATGCG
CAGTTCGGCAGCATCTTCCGCACCTTCCACAACCCCACCTACTTCTCAAGGCGCCTCGTGCGCTTCTCTGACCTCTACATGGCCTCCCTC
AGCTGCCTGCTCAACTACCGCGTGGACTTCACCTTCTACCCACGCCGTACGCCGCTGCAGCACGAGGCACCCCTCTGGATGGACCAGCTC
TGCACCGGCTGCATGAAGACCCCCTTCCTTGGTGACATGGCCCACATCCGCTGAGGGCACCTTTATTGTCTGGGACAGGCCCTCAGCCCC

>33561_33561_3_GNAI2-NT5DC2_GNAI2_chr3_50273885_ENST00000313601_NT5DC2_chr3_52563351_ENST00000422318_length(amino acids)=600AA_BP=116
MAPPASPPRPSHRLGSPRPHPRPAPPSVRGGREGASRSRSELPTRVLPAEGWWWERSGSGGAEPGRGPCGGRAAAGPADGGMGCTVSAED
KAAAERSKMIDKNLREDGEKAAREVKLLLLDLLPPEVCSLLNPAAIYANNEISLRDVEVYGFDYDYTLAQYADALHPEIFSTARDILIEH
YKYPEGIRKYDYNPSFAIRGLHYDIQKSLLMKIDAFHYVQLGTAYRGLQPVPDEEVIELYGGTQHIPLYQMSGFYGKGPSIKQFMDIFSL
PEMALLSCVVDYFLGHSLEFDQAHLYKDVTDAIRDVHVKGLMYQWIEQDMEKYILRGDETFAVLSRLVAHGKQLFLITNSPFSFVDKGMR
HMVGPDWRQLFDVVIVQADKPSFFTDRRKPFRKLDEKGSLQWDRITRLEKGKIYRQGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLR
HGWRTGAIIPELEREIRIINTEQYMHSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSR

--------------------------------------------------------------
>33561_33561_4_GNAI2-NT5DC2_GNAI2_chr3_50273885_ENST00000313601_NT5DC2_chr3_52563351_ENST00000459839_length(transcript)=1869nt_BP=502nt
AGTGCCGGGTCCCGGGGTTTGGAACCACCCCTATTGCCTTTTCTCCGCGTGGCCCCGCCTGCAGCCCAGGCCCGAGCCTGGGCTGCGCCT
AACTTCCCCCTTCGCTCCGCCCTCGAGCCAATCAACAGCCTCTAATCTCCTCTGGCCCCGCCTGCAAGCCCGCCCCGGCCCAGTCACAGG
CTTGGTTCGCCCAGGCCCCACCCCCGGCCCGCCCCGCCGTCGGTGCGCGGCGGTAGGGAAGGCGCCTCCCGCAGTCGCTCGGAACTGCCG
ACCCGAGTGCTTCCCGCAGAGGGCTGGTGGTGGGAGCGGAGTGGGTCGGGCGGGGCCGAGCCGGGCCGTGGGCCGTGTGGGGGCCGGGCG
GCGGCCGGGCCGGCGGACGGCGGGATGGGCTGCACCGTGAGCGCCGAGGACAAGGCGGCGGCCGAGCGCTCTAAGATGATCGACAAGAAC
CTGCGGGAGGACGGAGAGAAGGCGGCGCGGGAGGTGAAGTTGCTGCTGTTGGACCTCCTGCCCCCCGAGGTCTGCAGTCTCCTGAACCCA
GCAGCCATCTACGCCAACAACGAGATCAGCCTGCGTGACGTTGAGGTCTACGGCTTTGACTACGACTACACCCTGGCCCAGTATGCAGAC
GCACTGCACCCCGAGATCTTCAGTACCGCCCGTGACATCCTGATCGAGCACTACAAGAGCCTTCTGATGAAGATTGACGCCTTCCACTAC
GTGCAGCTGGGGACAGCCTACAGGGGCCTCCAGCCTGTGCCAGACGAGGAGGTGATTGAGCTGTATGGGGGTACCCAGCACATCCCACTA
TACCAGATGAGTGGCTTCTATGGCAAGGGTCCCTCCATTAAGCAGTTCATGGACATCTTCTCGCTACCGGAGATGGCTCTGCTGTCCTGT
GTGGTGGACTACTTTCTGGGCCACAGCCTGGAGTTTGACCAAGCACATCTCTACAAGGACGTGACGGACGCCATCCGAGACGTGCATGTG
AAGGGCCTCATGTACCAGTGGATCGAGCAGGACATGGAGAAGTACATCCTGAGAGGGGATGAGACGTTTGCTGTCCTGAGCCGCCTGGTG
GCCCATGGGAAACAGCTGTTCCTCATCACCAACAGTCCTTTCAGCTTCGTAGACAAGGGGATGCGGCACATGGTGGGTCCCGATTGGCGC
CAGCTCTTCGATGTGGTCATTGTCCAGGCAGACAAGCCCAGCTTCTTCACTGACCGGCGCAAGCCTTTCAGAAAACTCGATGAGAAGGGC
TCACTTCAGTGGGACCGGATCACCCGCTTGGAAAAGGGCAAGATCTATCGGCAGGGAAACCTGTTTGACTTCTTACGCTTGACGGAATGG
CGTGGCCCCCGCGTGCTCTACTTCGGGGACCACCTCTATAGTGATCTGGCGGATCTCATGCTGCGGCACGGCTGGCGCACAGGCGCCATC
ATCCCCGAGCTGGAGCGTGAGATCCGCATCATCAACACGGAGCAGTACATGCACTCGCTGACGTGGCAGCAGGCGCTCACGGGGCTGCTG
GAGCGCATGCAGACCTATCAGGACGCGGAGTCGAGGCAGGTGCTGGCTGCCTGGATGAAAGAGCGGCAGGAGCTGAGGTGCATCACCAAG
GCCCTGTTCAATGCGCAGTTCGGCAGCATCTTCCGCACCTTCCACAACCCCACCTACTTCTCAAGGCGCCTCGTGCGCTTCTCTGACCTC
TACATGGCCTCCCTCAGCTGCCTGCTCAACTACCGCGTGGACTTCACCTTCTACCCACGCCGTACGCCGCTGCAGCACGAGGCACCCCTC

>33561_33561_4_GNAI2-NT5DC2_GNAI2_chr3_50273885_ENST00000313601_NT5DC2_chr3_52563351_ENST00000459839_length(amino acids)=575AA_BP=116
MAPPASPPRPSHRLGSPRPHPRPAPPSVRGGREGASRSRSELPTRVLPAEGWWWERSGSGGAEPGRGPCGGRAAAGPADGGMGCTVSAED
KAAAERSKMIDKNLREDGEKAAREVKLLLLDLLPPEVCSLLNPAAIYANNEISLRDVEVYGFDYDYTLAQYADALHPEIFSTARDILIEH
YKSLLMKIDAFHYVQLGTAYRGLQPVPDEEVIELYGGTQHIPLYQMSGFYGKGPSIKQFMDIFSLPEMALLSCVVDYFLGHSLEFDQAHL
YKDVTDAIRDVHVKGLMYQWIEQDMEKYILRGDETFAVLSRLVAHGKQLFLITNSPFSFVDKGMRHMVGPDWRQLFDVVIVQADKPSFFT
DRRKPFRKLDEKGSLQWDRITRLEKGKIYRQGNLFDFLRLTEWRGPRVLYFGDHLYSDLADLMLRHGWRTGAIIPELEREIRIINTEQYM
HSLTWQQALTGLLERMQTYQDAESRQVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLNYRVDFTF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GNAI2-NT5DC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GNAI2-NT5DC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GNAI2-NT5DC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource