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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GNAQ-HNRNPH1 (FusionGDB2 ID:33599)

Fusion Gene Summary for GNAQ-HNRNPH1

Fusion gene summary

Fusion gene information	Fusion gene name: GNAQ-HNRNPH1
	Fusion gene ID: 33599
		Hgene	Tgene
	Gene symbol	GNAQ	HNRNPH1
	Gene ID	2776	3187
	Gene name	G protein subunit alpha q	heterogeneous nuclear ribonucleoprotein H1
	Synonyms	CMC1\|G-ALPHA-q\|GAQ\|SWS	HNRPH\|HNRPH1\|hnRNPH
	Cytomap	9q21.2	5q35.3
	Type of gene	protein-coding	protein-coding
	Description	guanine nucleotide-binding protein G(q) subunit alphaepididymis secretory sperm binding proteinguanine nucleotide binding protein (G protein), q polypeptideguanine nucleotide-binding protein alpha-q	heterogeneous nuclear ribonucleoprotein Hepididymis secretory sperm binding proteinheterogeneous nuclear ribonucleoprotein H1 (H)
	Modification date	20200313	20200320
	UniProtAcc	P50148	P31943
	Ensembl transtripts involved in fusion gene	ENST00000286548, ENST00000397476,	ENST00000511300, ENST00000524180, ENST00000329433, ENST00000356731, ENST00000393432, ENST00000442819, ENST00000510411,
Fusion gene scores	* DoF score	13 X 11 X 6=858	13 X 10 X 5=650
	# samples	16	14
	** MAII score	log2(16/858*10)=-2.42290574261218 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/650*10)=-2.21501289097085 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GNAQ [Title/Abstract] AND HNRNPH1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GNAQ(80412435)-HNRNPH1(179045324), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	HNRNPH1	GO:0043484	regulation of RNA splicing	16946708

Fusion gene breakpoints across GNAQ (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HNRNPH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	231N	GNAQ	chr9	80412435	-	HNRNPH1	chr5	179045324	-

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Fusion Gene ORF analysis for GNAQ-HNRNPH1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000286548	ENST00000511300	GNAQ	chr9	80412435	-	HNRNPH1	chr5	179045324	-
5CDS-intron	ENST00000286548	ENST00000524180	GNAQ	chr9	80412435	-	HNRNPH1	chr5	179045324	-
5UTR-3CDS	ENST00000397476	ENST00000329433	GNAQ	chr9	80412435	-	HNRNPH1	chr5	179045324	-
5UTR-3CDS	ENST00000397476	ENST00000356731	GNAQ	chr9	80412435	-	HNRNPH1	chr5	179045324	-
5UTR-3CDS	ENST00000397476	ENST00000393432	GNAQ	chr9	80412435	-	HNRNPH1	chr5	179045324	-
5UTR-3CDS	ENST00000397476	ENST00000442819	GNAQ	chr9	80412435	-	HNRNPH1	chr5	179045324	-
5UTR-3CDS	ENST00000397476	ENST00000510411	GNAQ	chr9	80412435	-	HNRNPH1	chr5	179045324	-
5UTR-intron	ENST00000397476	ENST00000511300	GNAQ	chr9	80412435	-	HNRNPH1	chr5	179045324	-
5UTR-intron	ENST00000397476	ENST00000524180	GNAQ	chr9	80412435	-	HNRNPH1	chr5	179045324	-
In-frame	ENST00000286548	ENST00000329433	GNAQ	chr9	80412435	-	HNRNPH1	chr5	179045324	-
In-frame	ENST00000286548	ENST00000356731	GNAQ	chr9	80412435	-	HNRNPH1	chr5	179045324	-
In-frame	ENST00000286548	ENST00000393432	GNAQ	chr9	80412435	-	HNRNPH1	chr5	179045324	-
In-frame	ENST00000286548	ENST00000442819	GNAQ	chr9	80412435	-	HNRNPH1	chr5	179045324	-
In-frame	ENST00000286548	ENST00000510411	GNAQ	chr9	80412435	-	HNRNPH1	chr5	179045324	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000286548	GNAQ	chr9	80412435	-	ENST00000393432	HNRNPH1	chr5	179045324	-	2424	828	199	1641	480
ENST00000286548	GNAQ	chr9	80412435	-	ENST00000442819	HNRNPH1	chr5	179045324	-	2423	828	199	1641	480
ENST00000286548	GNAQ	chr9	80412435	-	ENST00000356731	HNRNPH1	chr5	179045324	-	2423	828	199	1641	480
ENST00000286548	GNAQ	chr9	80412435	-	ENST00000329433	HNRNPH1	chr5	179045324	-	2371	828	199	1710	503
ENST00000286548	GNAQ	chr9	80412435	-	ENST00000510411	HNRNPH1	chr5	179045324	-	2361	828	199	1581	460

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000286548	ENST00000393432	GNAQ	chr9	80412435	-	HNRNPH1	chr5	179045324	-	0.000259202	0.9997408
ENST00000286548	ENST00000442819	GNAQ	chr9	80412435	-	HNRNPH1	chr5	179045324	-	0.000256729	0.9997433
ENST00000286548	ENST00000356731	GNAQ	chr9	80412435	-	HNRNPH1	chr5	179045324	-	0.000256729	0.9997433
ENST00000286548	ENST00000329433	GNAQ	chr9	80412435	-	HNRNPH1	chr5	179045324	-	0.000265959	0.999734
ENST00000286548	ENST00000510411	GNAQ	chr9	80412435	-	HNRNPH1	chr5	179045324	-	0.000235837	0.99976414

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Fusion Genomic Features for GNAQ-HNRNPH1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GNAQ-HNRNPH1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:80412435/chr5:179045324)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GNAQ P50148	HNRNPH1 P31943
FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs). {ECO:0000250, ECO:0000269\|PubMed:27852822}.	FUNCTION: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269\|PubMed:11003644, ECO:0000269\|PubMed:16946708}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GNAQ

chr9:80412435

chr5:179045324

ENST00000286548

180_186

201

360.0

Nucleotide binding

GTP

Hgene

GNAQ

chr9:80412435

chr5:179045324

ENST00000286548

46_53

201

360.0

Nucleotide binding

GTP

Hgene

GNAQ

chr9:80412435

chr5:179045324

ENST00000286548

178_186

201

360.0

Region

G2 motif

Hgene

GNAQ

chr9:80412435

chr5:179045324

ENST00000286548

41_54

201

360.0

Region

G1 motif

Tgene

HNRNPH1

chr9:80412435

chr5:179045324

ENST00000356731

289_364

178

130.66666666666666

Domain

RRM 3

Tgene

HNRNPH1

chr9:80412435

chr5:179045324

ENST00000393432

289_364

178

646.0

Domain

RRM 3

Tgene

HNRNPH1

chr9:80412435

chr5:179045324

ENST00000442819

289_364

178

655.6666666666666

Domain

RRM 3

Tgene

HNRNPH1

chr9:80412435

chr5:179045324

ENST00000356731

234_433

178

130.66666666666666

Region

Note=2 X 16 AA Gly-rich approximate repeats

Tgene

HNRNPH1

chr9:80412435

chr5:179045324

ENST00000356731

354_392

178

130.66666666666666

Region

Note=2 X 19 AA perfect repeats

Tgene

HNRNPH1

chr9:80412435

chr5:179045324

ENST00000393432

234_433

178

646.0

Region

Note=2 X 16 AA Gly-rich approximate repeats

Tgene

HNRNPH1

chr9:80412435

chr5:179045324

ENST00000393432

354_392

178

646.0

Region

Note=2 X 19 AA perfect repeats

Tgene

HNRNPH1

chr9:80412435

chr5:179045324

ENST00000442819

234_433

178

655.6666666666666

Region

Note=2 X 16 AA Gly-rich approximate repeats

Tgene

HNRNPH1

chr9:80412435

chr5:179045324

ENST00000442819

354_392

178

655.6666666666666

Region

Note=2 X 19 AA perfect repeats

Tgene

HNRNPH1

chr9:80412435

chr5:179045324

ENST00000356731

234_249

178

130.66666666666666

Repeat

Note=1-1

Tgene

HNRNPH1

chr9:80412435

chr5:179045324

ENST00000356731

354_372

178

130.66666666666666

Repeat

Note=2-1

Tgene

HNRNPH1

chr9:80412435

chr5:179045324

ENST00000356731

374_392

178

130.66666666666666

Repeat

Note=2-2

Tgene

HNRNPH1

chr9:80412435

chr5:179045324

ENST00000356731

418_433

178

130.66666666666666

Repeat

Note=1-2

Tgene

HNRNPH1

chr9:80412435

chr5:179045324

ENST00000393432

234_249

178

646.0

Repeat

Note=1-1

Tgene

HNRNPH1

chr9:80412435

chr5:179045324

ENST00000393432

354_372

178

646.0

Repeat

Note=2-1

Tgene

HNRNPH1

chr9:80412435

chr5:179045324

ENST00000393432

374_392

178

646.0

Repeat

Note=2-2

Tgene

HNRNPH1

chr9:80412435

chr5:179045324

ENST00000393432

418_433

178

646.0

Repeat

Note=1-2

Tgene

HNRNPH1

chr9:80412435

chr5:179045324

ENST00000442819

234_249

178

655.6666666666666

Repeat

Note=1-1

Tgene

HNRNPH1

chr9:80412435

chr5:179045324

ENST00000442819

354_372

178

655.6666666666666

Repeat

Note=2-1

Tgene

HNRNPH1

chr9:80412435

chr5:179045324

ENST00000442819

374_392

178

655.6666666666666

Repeat

Note=2-2

Tgene

HNRNPH1

chr9:80412435

chr5:179045324

ENST00000442819

418_433

178

655.6666666666666

Repeat

Note=1-2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GNAQ

chr9:80412435

chr5:179045324

ENST00000286548

38_359

201

360.0

Domain

G-alpha

Hgene

GNAQ

chr9:80412435

chr5:179045324

ENST00000286548

205_209

201

360.0

Nucleotide binding

GTP

Hgene

GNAQ

chr9:80412435

chr5:179045324

ENST00000286548

274_277

201

360.0

Nucleotide binding

GTP

Hgene

GNAQ

chr9:80412435

chr5:179045324

ENST00000286548

201_210

201

360.0

Region

G3 motif

Hgene

GNAQ

chr9:80412435

chr5:179045324

ENST00000286548

270_277

201

360.0

Region

G4 motif

Hgene

GNAQ

chr9:80412435

chr5:179045324

ENST00000286548

329_334

201

360.0

Region

G5 motif

Tgene

HNRNPH1

chr9:80412435

chr5:179045324

ENST00000356731

111_188

178

130.66666666666666

Domain

RRM 2

Tgene

HNRNPH1

chr9:80412435

chr5:179045324

ENST00000356731

11_90

178

130.66666666666666

Domain

RRM 1

Tgene

HNRNPH1

chr9:80412435

chr5:179045324

ENST00000393432

111_188

178

646.0

Domain

RRM 2

Tgene

HNRNPH1

chr9:80412435

chr5:179045324

ENST00000393432

11_90

178

646.0

Domain

RRM 1

Tgene

HNRNPH1

chr9:80412435

chr5:179045324

ENST00000442819

111_188

178

655.6666666666666

Domain

RRM 2

Tgene

HNRNPH1

chr9:80412435

chr5:179045324

ENST00000442819

11_90

178

655.6666666666666

Domain

RRM 1

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Fusion Gene Sequence for GNAQ-HNRNPH1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>33599_33599_1_GNAQ-HNRNPH1_GNAQ_chr9_80412435_ENST00000286548_HNRNPH1_chr5_179045324_ENST00000329433_length(transcript)=2371nt_BP=828nt
CGTCGGCCCAGACTATCCGCTCCCACCGCGCCCCCGGCCCACCTGGTGGCCCCGGCCCTGGCCGCCGCCCCCGCGGCGGTTCCCGGAGCT
CGTCCCGGACGCGCGCCCGGGCGGCGGGGGCTCGGCGGCCACCGCTGCCTCGGGGGAGCGAGGGCGGGAGGGTGTGTGTGCGCGCTGTGA
GCAGGGGGTGCCGGCGGGGCTGCAGCGGAGGCACTTTGGAAGAATGACTCTGGAGTCCATCATGGCGTGCTGCCTGAGCGAGGAGGCCAA
GGAAGCCCGGCGGATCAACGACGAGATCGAGCGGCAGCTCCGCAGGGACAAGCGGGACGCCCGCCGGGAGCTCAAGCTGCTGCTGCTCGG
GACAGGAGAGAGTGGCAAGAGTACGTTTATCAAGCAGATGAGAATCATCCATGGGTCAGGATACTCTGATGAAGATAAAAGGGGCTTCAC
CAAGCTGGTGTATCAGAACATCTTCACGGCCATGCAGGCCATGATCAGAGCCATGGACACACTCAAGATCCCATACAAGTATGAGCACAA
TAAGGCTCATGCACAATTAGTTCGAGAAGTTGATGTGGAGAAGGTGTCTGCTTTTGAGAATCCATATGTAGATGCAATAAAGAGTTTATG
GAATGATCCTGGAATCCAGGAATGCTATGATAGACGACGAGAATATCAATTATCTGACTCTACCAAATACTATCTTAATGACTTGGACCG
CGTAGCTGACCCTGCCTACCTGCCTACGCAACAAGATGTGCTTAGAGTTCGAGTCCCCACCACAGGGATCATCGAATACCCCTTTGACTT
ACAAAGTGTCATTTTCAGGTATATTGAAATCTTTAAGAGCAGTAGAGCTGAAGTTAGAACTCATTATGATCCACCACGAAAGCTTATGGC
CATGCAGCGGCCAGGTCCTTATGACAGACCTGGGGCTGGTAGAGGGTATAACAGCATTGGCAGAGGAGCTGGCTTTGAGAGGATGAGGCG
TGGTGCTTATGGTGGAGGCTATGGAGGCTATGATGATTACAATGGCTATAATGATGGCTATGGATTTGGGTCAGATAGATTTGGAAGAGA
CCTCAATTACTGTTTTTCAGGAATGTCTGATCACAGATACGGGGATGGTGGCTCTACTTTCCAGAGCACAACAGGACACTGTGTACACAT
GCGGGGATTACCTTACAGAGCTACTGAGAATGACATTTATAATTTTTTTTCACCGCTCAACCCTGTGAGAGTACACATTGAAATTGGTCC
TGATGGCAGAGTAACTGGTGAAGCAGATGTCGAGTTCGCAACTCATGAAGATGCTGTGGCAGCTATGTCAAAAGACAAAGCAAATATGCA
ACACAGATATGTAGAACTCTTCTTGAATTCTACAGCAGGAGCAAGCGGTGGTGCTTACGAACACAGATATGTAGAACTCTTCTTGAATTC
TACAGCAGGAGCAAGCGGTGGTGCTTATGGTAGCCAAATGATGGGAGGCATGGGCTTGTCAAACCAGTCCAGCTACGGGGGCCCAGCCAG
CCAGCAGCTGAGTGGGGGTTACGGAGGCGGCTACGGTGGCCAGAGCAGCATGAGTGGATACGGTAACCAAGGAGCAGTGAACAGCAGCTA
CTACAGTAGTGGAAGCCGTGCATCTATGGGCGTGAACGGAATGGGAGGGTTGTCTAGCATGTCCAGTATGAGTGGTGGATGGGGAATGTA
ATTGATCGATCCTGATCACTGACTCTTGGTCAACCTTTTTTTTTTTTTTTTTTTTTTCTTTAAGAAAACTTCAGTTTAACAGTTTCTGCA
ATACAAGCTTGTGATTTATGCTTACTCTAAGTGGAAATCAGGATTGTTATGAAGACTTAAGGCCCAGTATTTTTGAATACAATACTCATC
TAGGATGTAACAGTGAAGCTGAGTAAACTATAACTGTTAAACTTAAGTTCCAGCTTTTCTCAAGTTAGTTATAGGATGTACTTAAGCAGT
AAGCGTATTTAGGTAAAAGCAGTTGAATTATGTTAAATGTTGCCCTTTGCCACGTTAAATTGAACACTGTTTTGGATGCATGTTGAAAGA
CATGCTTTTATTTTTTTGTAAAACAATATAGGAGCTGTGTCTACTATTAAAAGTGAAACATTTTGGCATGTTTGTTAATTCTAGTTTCAT
TTAATAACCTGTAAGGCACGTAAGTTTAAGCTTTTTTTTTTTTTAAGTTAATGGGAAAAATTTGAGACGCAATACCAATACTTAGGATTT
TGGTCTTGGTGTTTGTATGAAATTCTGAGGCCTTGATTTAAATCTTTCATTGTATTGTGATTTCCTTTTAGGTATATTGCGCTAAGTGAA

>33599_33599_1_GNAQ-HNRNPH1_GNAQ_chr9_80412435_ENST00000286548_HNRNPH1_chr5_179045324_ENST00000329433_length(amino acids)=503AA_BP=208
MQRRHFGRMTLESIMACCLSEEAKEARRINDEIERQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDKRGFTKLVYQN
IFTAMQAMIRAMDTLKIPYKYEHNKAHAQLVREVDVEKVSAFENPYVDAIKSLWNDPGIQECYDRRREYQLSDSTKYYLNDLDRVADPAY
LPTQQDVLRVRVPTTGIIEYPFDLQSVIFRYIEIFKSSRAEVRTHYDPPRKLMAMQRPGPYDRPGAGRGYNSIGRGAGFERMRRGAYGGG
YGGYDDYNGYNDGYGFGSDRFGRDLNYCFSGMSDHRYGDGGSTFQSTTGHCVHMRGLPYRATENDIYNFFSPLNPVRVHIEIGPDGRVTG
EADVEFATHEDAVAAMSKDKANMQHRYVELFLNSTAGASGGAYEHRYVELFLNSTAGASGGAYGSQMMGGMGLSNQSSYGGPASQQLSGG

--------------------------------------------------------------
>33599_33599_2_GNAQ-HNRNPH1_GNAQ_chr9_80412435_ENST00000286548_HNRNPH1_chr5_179045324_ENST00000356731_length(transcript)=2423nt_BP=828nt
CGTCGGCCCAGACTATCCGCTCCCACCGCGCCCCCGGCCCACCTGGTGGCCCCGGCCCTGGCCGCCGCCCCCGCGGCGGTTCCCGGAGCT
CGTCCCGGACGCGCGCCCGGGCGGCGGGGGCTCGGCGGCCACCGCTGCCTCGGGGGAGCGAGGGCGGGAGGGTGTGTGTGCGCGCTGTGA
GCAGGGGGTGCCGGCGGGGCTGCAGCGGAGGCACTTTGGAAGAATGACTCTGGAGTCCATCATGGCGTGCTGCCTGAGCGAGGAGGCCAA
GGAAGCCCGGCGGATCAACGACGAGATCGAGCGGCAGCTCCGCAGGGACAAGCGGGACGCCCGCCGGGAGCTCAAGCTGCTGCTGCTCGG
GACAGGAGAGAGTGGCAAGAGTACGTTTATCAAGCAGATGAGAATCATCCATGGGTCAGGATACTCTGATGAAGATAAAAGGGGCTTCAC
CAAGCTGGTGTATCAGAACATCTTCACGGCCATGCAGGCCATGATCAGAGCCATGGACACACTCAAGATCCCATACAAGTATGAGCACAA
TAAGGCTCATGCACAATTAGTTCGAGAAGTTGATGTGGAGAAGGTGTCTGCTTTTGAGAATCCATATGTAGATGCAATAAAGAGTTTATG
GAATGATCCTGGAATCCAGGAATGCTATGATAGACGACGAGAATATCAATTATCTGACTCTACCAAATACTATCTTAATGACTTGGACCG
CGTAGCTGACCCTGCCTACCTGCCTACGCAACAAGATGTGCTTAGAGTTCGAGTCCCCACCACAGGGATCATCGAATACCCCTTTGACTT
ACAAAGTGTCATTTTCAGGTATATTGAAATCTTTAAGAGCAGTAGAGCTGAAGTTAGAACTCATTATGATCCACCACGAAAGCTTATGGC
CATGCAGCGGCCAGGTCCTTATGACAGACCTGGGGCTGGTAGAGGGTATAACAGCATTGGCAGAGGAGCTGGCTTTGAGAGGATGAGGCG
TGGTGCTTATGGTGGAGGCTATGGAGGCTATGATGATTACAATGGCTATAATGATGGCTATGGATTTGGGTCAGATAGATTTGGAAGAGA
CCTCAATTACTGTTTTTCAGGAATGTCTGATCACAGATACGGGGATGGTGGCTCTACTTTCCAGAGCACAACAGGACACTGTGTACACAT
GCGGGGATTACCTTACAGAGCTACTGAGAATGACATTTATAATTTTTTTTCACCGCTCAACCCTGTGAGAGTACACATTGAAATTGGTCC
TGATGGCAGAGTAACTGGTGAAGCAGATGTCGAGTTCGCAACTCATGAAGATGCTGTGGCAGCTATGTCAAAAGACAAAGCAAATATGCA
ACACAGATATGTAGAACTCTTCTTGAATTCTACAGCAGGAGCAAGCGGTGGTGCTTACGAACACAGATATGTAGAACTCTTCTTGAATTC
TACAGCAGGAGCAAGCGGTGGTGCTTATGGTAGCCAAATGATGGGAGGCATGGGCTTGTCAAACCAGTCCAGCTACGGGGGCCCAGCCAG
CCAGCAGCTGAGTGGGGGTTACGGAGGCGGCTACGGTGGCCAGAGCAGCATGAGTGGATACGACCAAGTTTTACAGGAAAACTCCAGTGA
TTTTCAATCAAACATTGCATAGGTAACCAAGGAGCAGTGAACAGCAGCTACTACAGTAGTGGAAGCCGTGCATCTATGGGCGTGAACGGA
ATGGGAGGGTTGTCTAGCATGTCCAGTATGAGTGGTGGATGGGGAATGTAATTGATCGATCCTGATCACTGACTCTTGGTCAACCTTTTT
TTTTTTTTTTTTTTTTTCTTTAAGAAAACTTCAGTTTAACAGTTTCTGCAATACAAGCTTGTGATTTATGCTTACTCTAAGTGGAAATCA
GGATTGTTATGAAGACTTAAGGCCCAGTATTTTTGAATACAATACTCATCTAGGATGTAACAGTGAAGCTGAGTAAACTATAACTGTTAA
ACTTAAGTTCCAGCTTTTCTCAAGTTAGTTATAGGATGTACTTAAGCAGTAAGCGTATTTAGGTAAAAGCAGTTGAATTATGTTAAATGT
TGCCCTTTGCCACGTTAAATTGAACACTGTTTTGGATGCATGTTGAAAGACATGCTTTTATTTTTTTGTAAAACAATATAGGAGCTGTGT
CTACTATTAAAAGTGAAACATTTTGGCATGTTTGTTAATTCTAGTTTCATTTAATAACCTGTAAGGCACGTAAGTTTAAGCTTTTTTTTT
TTTTAAGTTAATGGGAAAAATTTGAGACGCAATACCAATACTTAGGATTTTGGTCTTGGTGTTTGTATGAAATTCTGAGGCCTTGATTTA

>33599_33599_2_GNAQ-HNRNPH1_GNAQ_chr9_80412435_ENST00000286548_HNRNPH1_chr5_179045324_ENST00000356731_length(amino acids)=480AA_BP=208
MQRRHFGRMTLESIMACCLSEEAKEARRINDEIERQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDKRGFTKLVYQN
IFTAMQAMIRAMDTLKIPYKYEHNKAHAQLVREVDVEKVSAFENPYVDAIKSLWNDPGIQECYDRRREYQLSDSTKYYLNDLDRVADPAY
LPTQQDVLRVRVPTTGIIEYPFDLQSVIFRYIEIFKSSRAEVRTHYDPPRKLMAMQRPGPYDRPGAGRGYNSIGRGAGFERMRRGAYGGG
YGGYDDYNGYNDGYGFGSDRFGRDLNYCFSGMSDHRYGDGGSTFQSTTGHCVHMRGLPYRATENDIYNFFSPLNPVRVHIEIGPDGRVTG
EADVEFATHEDAVAAMSKDKANMQHRYVELFLNSTAGASGGAYEHRYVELFLNSTAGASGGAYGSQMMGGMGLSNQSSYGGPASQQLSGG

--------------------------------------------------------------
>33599_33599_3_GNAQ-HNRNPH1_GNAQ_chr9_80412435_ENST00000286548_HNRNPH1_chr5_179045324_ENST00000393432_length(transcript)=2424nt_BP=828nt
CGTCGGCCCAGACTATCCGCTCCCACCGCGCCCCCGGCCCACCTGGTGGCCCCGGCCCTGGCCGCCGCCCCCGCGGCGGTTCCCGGAGCT
CGTCCCGGACGCGCGCCCGGGCGGCGGGGGCTCGGCGGCCACCGCTGCCTCGGGGGAGCGAGGGCGGGAGGGTGTGTGTGCGCGCTGTGA
GCAGGGGGTGCCGGCGGGGCTGCAGCGGAGGCACTTTGGAAGAATGACTCTGGAGTCCATCATGGCGTGCTGCCTGAGCGAGGAGGCCAA
GGAAGCCCGGCGGATCAACGACGAGATCGAGCGGCAGCTCCGCAGGGACAAGCGGGACGCCCGCCGGGAGCTCAAGCTGCTGCTGCTCGG
GACAGGAGAGAGTGGCAAGAGTACGTTTATCAAGCAGATGAGAATCATCCATGGGTCAGGATACTCTGATGAAGATAAAAGGGGCTTCAC
CAAGCTGGTGTATCAGAACATCTTCACGGCCATGCAGGCCATGATCAGAGCCATGGACACACTCAAGATCCCATACAAGTATGAGCACAA
TAAGGCTCATGCACAATTAGTTCGAGAAGTTGATGTGGAGAAGGTGTCTGCTTTTGAGAATCCATATGTAGATGCAATAAAGAGTTTATG
GAATGATCCTGGAATCCAGGAATGCTATGATAGACGACGAGAATATCAATTATCTGACTCTACCAAATACTATCTTAATGACTTGGACCG
CGTAGCTGACCCTGCCTACCTGCCTACGCAACAAGATGTGCTTAGAGTTCGAGTCCCCACCACAGGGATCATCGAATACCCCTTTGACTT
ACAAAGTGTCATTTTCAGGTATATTGAAATCTTTAAGAGCAGTAGAGCTGAAGTTAGAACTCATTATGATCCACCACGAAAGCTTATGGC
CATGCAGCGGCCAGGTCCTTATGACAGACCTGGGGCTGGTAGAGGGTATAACAGCATTGGCAGAGGAGCTGGCTTTGAGAGGATGAGGCG
TGGTGCTTATGGTGGAGGCTATGGAGGCTATGATGATTACAATGGCTATAATGATGGCTATGGATTTGGGTCAGATAGATTTGGAAGAGA
CCTCAATTACTGTTTTTCAGGAATGTCTGATCACAGATACGGGGATGGTGGCTCTACTTTCCAGAGCACAACAGGACACTGTGTACACAT
GCGGGGATTACCTTACAGAGCTACTGAGAATGACATTTATAATTTTTTTTCACCGCTCAACCCTGTGAGAGTACACATTGAAATTGGTCC
TGATGGCAGAGTAACTGGTGAAGCAGATGTCGAGTTCGCAACTCATGAAGATGCTGTGGCAGCTATGTCAAAAGACAAAGCAAATATGCA
ACACAGATATGTAGAACTCTTCTTGAATTCTACAGCAGGAGCAAGCGGTGGTGCTTACGAACACAGATATGTAGAACTCTTCTTGAATTC
TACAGCAGGAGCAAGCGGTGGTGCTTATGGTAGCCAAATGATGGGAGGCATGGGCTTGTCAAACCAGTCCAGCTACGGGGGCCCAGCCAG
CCAGCAGCTGAGTGGGGGTTACGGAGGCGGCTACGGTGGCCAGAGCAGCATGAGTGGATACGACCAAGTTTTACAGGAAAACTCCAGTGA
TTTTCAATCAAACATTGCATAGGTAACCAAGGAGCAGTGAACAGCAGCTACTACAGTAGTGGAAGCCGTGCATCTATGGGCGTGAACGGA
ATGGGAGGGTTGTCTAGCATGTCCAGTATGAGTGGTGGATGGGGAATGTAATTGATCGATCCTGATCACTGACTCTTGGTCAACCTTTTT
TTTTTTTTTTTTTTTTTCTTTAAGAAAACTTCAGTTTAACAGTTTCTGCAATACAAGCTTGTGATTTATGCTTACTCTAAGTGGAAATCA
GGATTGTTATGAAGACTTAAGGCCCAGTATTTTTGAATACAATACTCATCTAGGATGTAACAGTGAAGCTGAGTAAACTATAACTGTTAA
ACTTAAGTTCCAGCTTTTCTCAAGTTAGTTATAGGATGTACTTAAGCAGTAAGCGTATTTAGGTAAAAGCAGTTGAATTATGTTAAATGT
TGCCCTTTGCCACGTTAAATTGAACACTGTTTTGGATGCATGTTGAAAGACATGCTTTTATTTTTTTGTAAAACAATATAGGAGCTGTGT
CTACTATTAAAAGTGAAACATTTTGGCATGTTTGTTAATTCTAGTTTCATTTAATAACCTGTAAGGCACGTAAGTTTAAGCTTTTTTTTT
TTTTAAGTTAATGGGAAAAATTTGAGACGCAATACCAATACTTAGGATTTTGGTCTTGGTGTTTGTATGAAATTCTGAGGCCTTGATTTA

>33599_33599_3_GNAQ-HNRNPH1_GNAQ_chr9_80412435_ENST00000286548_HNRNPH1_chr5_179045324_ENST00000393432_length(amino acids)=480AA_BP=208
MQRRHFGRMTLESIMACCLSEEAKEARRINDEIERQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDKRGFTKLVYQN
IFTAMQAMIRAMDTLKIPYKYEHNKAHAQLVREVDVEKVSAFENPYVDAIKSLWNDPGIQECYDRRREYQLSDSTKYYLNDLDRVADPAY
LPTQQDVLRVRVPTTGIIEYPFDLQSVIFRYIEIFKSSRAEVRTHYDPPRKLMAMQRPGPYDRPGAGRGYNSIGRGAGFERMRRGAYGGG
YGGYDDYNGYNDGYGFGSDRFGRDLNYCFSGMSDHRYGDGGSTFQSTTGHCVHMRGLPYRATENDIYNFFSPLNPVRVHIEIGPDGRVTG
EADVEFATHEDAVAAMSKDKANMQHRYVELFLNSTAGASGGAYEHRYVELFLNSTAGASGGAYGSQMMGGMGLSNQSSYGGPASQQLSGG

--------------------------------------------------------------
>33599_33599_4_GNAQ-HNRNPH1_GNAQ_chr9_80412435_ENST00000286548_HNRNPH1_chr5_179045324_ENST00000442819_length(transcript)=2423nt_BP=828nt
CGTCGGCCCAGACTATCCGCTCCCACCGCGCCCCCGGCCCACCTGGTGGCCCCGGCCCTGGCCGCCGCCCCCGCGGCGGTTCCCGGAGCT
CGTCCCGGACGCGCGCCCGGGCGGCGGGGGCTCGGCGGCCACCGCTGCCTCGGGGGAGCGAGGGCGGGAGGGTGTGTGTGCGCGCTGTGA
GCAGGGGGTGCCGGCGGGGCTGCAGCGGAGGCACTTTGGAAGAATGACTCTGGAGTCCATCATGGCGTGCTGCCTGAGCGAGGAGGCCAA
GGAAGCCCGGCGGATCAACGACGAGATCGAGCGGCAGCTCCGCAGGGACAAGCGGGACGCCCGCCGGGAGCTCAAGCTGCTGCTGCTCGG
GACAGGAGAGAGTGGCAAGAGTACGTTTATCAAGCAGATGAGAATCATCCATGGGTCAGGATACTCTGATGAAGATAAAAGGGGCTTCAC
CAAGCTGGTGTATCAGAACATCTTCACGGCCATGCAGGCCATGATCAGAGCCATGGACACACTCAAGATCCCATACAAGTATGAGCACAA
TAAGGCTCATGCACAATTAGTTCGAGAAGTTGATGTGGAGAAGGTGTCTGCTTTTGAGAATCCATATGTAGATGCAATAAAGAGTTTATG
GAATGATCCTGGAATCCAGGAATGCTATGATAGACGACGAGAATATCAATTATCTGACTCTACCAAATACTATCTTAATGACTTGGACCG
CGTAGCTGACCCTGCCTACCTGCCTACGCAACAAGATGTGCTTAGAGTTCGAGTCCCCACCACAGGGATCATCGAATACCCCTTTGACTT
ACAAAGTGTCATTTTCAGGTATATTGAAATCTTTAAGAGCAGTAGAGCTGAAGTTAGAACTCATTATGATCCACCACGAAAGCTTATGGC
CATGCAGCGGCCAGGTCCTTATGACAGACCTGGGGCTGGTAGAGGGTATAACAGCATTGGCAGAGGAGCTGGCTTTGAGAGGATGAGGCG
TGGTGCTTATGGTGGAGGCTATGGAGGCTATGATGATTACAATGGCTATAATGATGGCTATGGATTTGGGTCAGATAGATTTGGAAGAGA
CCTCAATTACTGTTTTTCAGGAATGTCTGATCACAGATACGGGGATGGTGGCTCTACTTTCCAGAGCACAACAGGACACTGTGTACACAT
GCGGGGATTACCTTACAGAGCTACTGAGAATGACATTTATAATTTTTTTTCACCGCTCAACCCTGTGAGAGTACACATTGAAATTGGTCC
TGATGGCAGAGTAACTGGTGAAGCAGATGTCGAGTTCGCAACTCATGAAGATGCTGTGGCAGCTATGTCAAAAGACAAAGCAAATATGCA
ACACAGATATGTAGAACTCTTCTTGAATTCTACAGCAGGAGCAAGCGGTGGTGCTTACGAACACAGATATGTAGAACTCTTCTTGAATTC
TACAGCAGGAGCAAGCGGTGGTGCTTATGGTAGCCAAATGATGGGAGGCATGGGCTTGTCAAACCAGTCCAGCTACGGGGGCCCAGCCAG
CCAGCAGCTGAGTGGGGGTTACGGAGGCGGCTACGGTGGCCAGAGCAGCATGAGTGGATACGACCAAGTTTTACAGGAAAACTCCAGTGA
TTTTCAATCAAACATTGCATAGGTAACCAAGGAGCAGTGAACAGCAGCTACTACAGTAGTGGAAGCCGTGCATCTATGGGCGTGAACGGA
ATGGGAGGGTTGTCTAGCATGTCCAGTATGAGTGGTGGATGGGGAATGTAATTGATCGATCCTGATCACTGACTCTTGGTCAACCTTTTT
TTTTTTTTTTTTTTTTTCTTTAAGAAAACTTCAGTTTAACAGTTTCTGCAATACAAGCTTGTGATTTATGCTTACTCTAAGTGGAAATCA
GGATTGTTATGAAGACTTAAGGCCCAGTATTTTTGAATACAATACTCATCTAGGATGTAACAGTGAAGCTGAGTAAACTATAACTGTTAA
ACTTAAGTTCCAGCTTTTCTCAAGTTAGTTATAGGATGTACTTAAGCAGTAAGCGTATTTAGGTAAAAGCAGTTGAATTATGTTAAATGT
TGCCCTTTGCCACGTTAAATTGAACACTGTTTTGGATGCATGTTGAAAGACATGCTTTTATTTTTTTGTAAAACAATATAGGAGCTGTGT
CTACTATTAAAAGTGAAACATTTTGGCATGTTTGTTAATTCTAGTTTCATTTAATAACCTGTAAGGCACGTAAGTTTAAGCTTTTTTTTT
TTTTAAGTTAATGGGAAAAATTTGAGACGCAATACCAATACTTAGGATTTTGGTCTTGGTGTTTGTATGAAATTCTGAGGCCTTGATTTA

>33599_33599_4_GNAQ-HNRNPH1_GNAQ_chr9_80412435_ENST00000286548_HNRNPH1_chr5_179045324_ENST00000442819_length(amino acids)=480AA_BP=208
MQRRHFGRMTLESIMACCLSEEAKEARRINDEIERQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDKRGFTKLVYQN
IFTAMQAMIRAMDTLKIPYKYEHNKAHAQLVREVDVEKVSAFENPYVDAIKSLWNDPGIQECYDRRREYQLSDSTKYYLNDLDRVADPAY
LPTQQDVLRVRVPTTGIIEYPFDLQSVIFRYIEIFKSSRAEVRTHYDPPRKLMAMQRPGPYDRPGAGRGYNSIGRGAGFERMRRGAYGGG
YGGYDDYNGYNDGYGFGSDRFGRDLNYCFSGMSDHRYGDGGSTFQSTTGHCVHMRGLPYRATENDIYNFFSPLNPVRVHIEIGPDGRVTG
EADVEFATHEDAVAAMSKDKANMQHRYVELFLNSTAGASGGAYEHRYVELFLNSTAGASGGAYGSQMMGGMGLSNQSSYGGPASQQLSGG

--------------------------------------------------------------
>33599_33599_5_GNAQ-HNRNPH1_GNAQ_chr9_80412435_ENST00000286548_HNRNPH1_chr5_179045324_ENST00000510411_length(transcript)=2361nt_BP=828nt
CGTCGGCCCAGACTATCCGCTCCCACCGCGCCCCCGGCCCACCTGGTGGCCCCGGCCCTGGCCGCCGCCCCCGCGGCGGTTCCCGGAGCT
CGTCCCGGACGCGCGCCCGGGCGGCGGGGGCTCGGCGGCCACCGCTGCCTCGGGGGAGCGAGGGCGGGAGGGTGTGTGTGCGCGCTGTGA
GCAGGGGGTGCCGGCGGGGCTGCAGCGGAGGCACTTTGGAAGAATGACTCTGGAGTCCATCATGGCGTGCTGCCTGAGCGAGGAGGCCAA
GGAAGCCCGGCGGATCAACGACGAGATCGAGCGGCAGCTCCGCAGGGACAAGCGGGACGCCCGCCGGGAGCTCAAGCTGCTGCTGCTCGG
GACAGGAGAGAGTGGCAAGAGTACGTTTATCAAGCAGATGAGAATCATCCATGGGTCAGGATACTCTGATGAAGATAAAAGGGGCTTCAC
CAAGCTGGTGTATCAGAACATCTTCACGGCCATGCAGGCCATGATCAGAGCCATGGACACACTCAAGATCCCATACAAGTATGAGCACAA
TAAGGCTCATGCACAATTAGTTCGAGAAGTTGATGTGGAGAAGGTGTCTGCTTTTGAGAATCCATATGTAGATGCAATAAAGAGTTTATG
GAATGATCCTGGAATCCAGGAATGCTATGATAGACGACGAGAATATCAATTATCTGACTCTACCAAATACTATCTTAATGACTTGGACCG
CGTAGCTGACCCTGCCTACCTGCCTACGCAACAAGATGTGCTTAGAGTTCGAGTCCCCACCACAGGGATCATCGAATACCCCTTTGACTT
ACAAAGTGTCATTTTCAGGTATATTGAAATCTTTAAGAGCAGTAGAGCTGAAGTTAGAACTCATTATGATCCACCACGAAAGCTTATGGC
CATGCAGCGGCCAGGTCCTTATGACAGACCTGGGGCTGGTAGAGGGTATAACAGCATTGGCAGAGGAGCTGGCTTTGAGAGGATGAGGCG
TGGTGCTTATGGTGGAGGCTATGGAGGCTATGATGATTACAATGGCTATAATGATGGCTATGGATTTGGGTCAGATAGATTTGGAAGAGA
CCTCAATTACTGTTTTTCAGGAATGTCTGATCACAGATACGGGGATGGTGGCTCTACTTTCCAGAGCACAACAGGACACTGTGTACACAT
GCGGGGATTACCTTACAGAGCTACTGAGAATGACATTTATAATTTTTTTTCACCGCTCAACCCTGTGAGAGTACACATTGAAATTGGTCC
TGATGGCAGAGTAACTGGTGAAGCAGATGTCGAGTTCGCAACTCATGAAGATGCTGTGGCAGCTATGTCAAAAGACAAAGCAAATATGCA
ACACAGATATGTAGAACTCTTCTTGAATTCTACAGCAGGAGCAAGCGGTGGTGCTTACGGTAGCCAAATGCTAGGAGGCATGGGTTTGTC
AAACCAGTCCAGCTACGGGGGCCCAGCCAGCCAGCAGCTGAGTGGGGGTTACGGAGGCGGCTACGGTGGCCAGAGCAGCATGAGTGGATA
CGACCAAGTTTTACAGGAAAACTCCAGTGATTTTCAATCAAACATTGCATAGGTAACCAAGGAGCAGTGAACAGCAGCTACTACAGTAGT
GGAAGCCGTGCATCTATGGGCGTGAACGGAATGGGAGGGTTGTCTAGCATGTCCAGTATGAGTGGTGGATGGGGAATGTAATTGATCGAT
CCTGATCACTGACTCTTGGTCAACCTTTTTTTTTTTTTTTTTTTTTTCTTTAAGAAAACTTCAGTTTAACAGTTTCTGCAATACAAGCTT
GTGATTTATGCTTACTCTAAGTGGAAATCAGGATTGTTATGAAGACTTAAGGCCCAGTATTTTTGAATACAATACTCATCTAGGATGTAA
CAGTGAAGCTGAGTAAACTATAACTGTTAAACTTAAGTTCCAGCTTTTCTCAAGTTAGTTATAGGATGTACTTAAGCAGTAAGCGTATTT
AGGTAAAAGCAGTTGAATTATGTTAAATGTTGCCCTTTGCCACGTTAAATTGAACACTGTTTTGGATGCATGTTGAAAGACATGCTTTTA
TTTTTTTGTAAAACAATATAGGAGCTGTGTCTACTATTAAAAGTGAAACATTTTGGCATGTTTGTTAATTCTAGTTTCATTTAATAACCT
GTAAGGCACGTAAGTTTAAGCTTTTTTTTTTTTTAAGTTAATGGGAAAAATTTGAGACGCAATACCAATACTTAGGATTTTGGTCTTGGT
GTTTGTATGAAATTCTGAGGCCTTGATTTAAATCTTTCATTGTATTGTGATTTCCTTTTAGGTATATTGCGCTAAGTGAAACTTGTCAAA

>33599_33599_5_GNAQ-HNRNPH1_GNAQ_chr9_80412435_ENST00000286548_HNRNPH1_chr5_179045324_ENST00000510411_length(amino acids)=460AA_BP=208
MQRRHFGRMTLESIMACCLSEEAKEARRINDEIERQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDKRGFTKLVYQN
IFTAMQAMIRAMDTLKIPYKYEHNKAHAQLVREVDVEKVSAFENPYVDAIKSLWNDPGIQECYDRRREYQLSDSTKYYLNDLDRVADPAY
LPTQQDVLRVRVPTTGIIEYPFDLQSVIFRYIEIFKSSRAEVRTHYDPPRKLMAMQRPGPYDRPGAGRGYNSIGRGAGFERMRRGAYGGG
YGGYDDYNGYNDGYGFGSDRFGRDLNYCFSGMSDHRYGDGGSTFQSTTGHCVHMRGLPYRATENDIYNFFSPLNPVRVHIEIGPDGRVTG
EADVEFATHEDAVAAMSKDKANMQHRYVELFLNSTAGASGGAYGSQMLGGMGLSNQSSYGGPASQQLSGGYGGGYGGQSSMSGYDQVLQE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for GNAQ-HNRNPH1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GNAQ-HNRNPH1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for GNAQ-HNRNPH1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source