FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:AKAP8-BRD4 (FusionGDB2 ID:3365)

Fusion Gene Summary for AKAP8-BRD4

check button Fusion gene summary
Fusion gene informationFusion gene name: AKAP8-BRD4
Fusion gene ID: 3365
HgeneTgene
Gene symbol

AKAP8

BRD4

Gene ID

10270

23476

Gene nameA-kinase anchoring protein 8bromodomain containing 4
SynonymsAKAP 95|AKAP-8|AKAP-95|AKAP95CAP|HUNK1|HUNKI|MCAP
Cytomap

19p13.12

19p13.12

Type of geneprotein-codingprotein-coding
DescriptionA-kinase anchor protein 8A kinase (PRKA) anchor protein 8A-kinase anchor protein, 95kDabromodomain-containing protein 4chromosome-associated proteinmitotic chromosome-associated protein
Modification date2020031320200329
UniProtAcc

O43823

O60885

Ensembl transtripts involved in fusion geneENST00000269701, ENST00000602230, 
ENST00000263377, ENST00000360016, 
ENST00000371835, 
Fusion gene scores* DoF score13 X 14 X 9=163815 X 19 X 13=3705
# samples 1728
** MAII scorelog2(17/1638*10)=-3.26832870550331
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(28/3705*10)=-3.72597481024823
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AKAP8 [Title/Abstract] AND BRD4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAKAP8(15465385)-BRD4(15359824), # samples:1
AKAP8(15487787)-BRD4(15367984), # samples:1
AKAP8(15490524)-BRD4(15367984), # samples:1
AKAP8(15487787)-BRD4(15366403), # samples:1
Anticipated loss of major functional domain due to fusion event.AKAP8-BRD4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
AKAP8-BRD4 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
AKAP8-BRD4 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
AKAP8-BRD4 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
AKAP8-BRD4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
AKAP8-BRD4 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBRD4

GO:0032968

positive regulation of transcription elongation from RNA polymerase II promoter

19103749|23086925

TgeneBRD4

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

19103749

TgeneBRD4

GO:0045944

positive regulation of transcription by RNA polymerase II

23086925|23317504|24360279

TgeneBRD4

GO:0050727

regulation of inflammatory response

19103749

TgeneBRD4

GO:1901407

regulation of phosphorylation of RNA polymerase II C-terminal domain

23086925


check buttonFusion gene breakpoints across AKAP8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BRD4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-GV-A3QI-01AAKAP8chr19

15465385

-BRD4chr19

15359824

-
ChimerDB4BLCATCGA-ZF-AA4V-01AAKAP8chr19

15487787

-BRD4chr19

15367984

-
ChimerDB4BLCATCGA-ZF-AA4V-01AAKAP8chr19

15490524

-BRD4chr19

15367984

-
ChimerDB4OVTCGA-04-1338-01AAKAP8chr19

15487787

-BRD4chr19

15366403

-


Top

Fusion Gene ORF analysis for AKAP8-BRD4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000269701ENST00000602230AKAP8chr19

15487787

-BRD4chr19

15367984

-
5CDS-5UTRENST00000269701ENST00000602230AKAP8chr19

15490524

-BRD4chr19

15367984

-
5CDS-intronENST00000269701ENST00000602230AKAP8chr19

15487787

-BRD4chr19

15366403

-
Frame-shiftENST00000269701ENST00000263377AKAP8chr19

15487787

-BRD4chr19

15367984

-
Frame-shiftENST00000269701ENST00000263377AKAP8chr19

15487787

-BRD4chr19

15366403

-
Frame-shiftENST00000269701ENST00000360016AKAP8chr19

15487787

-BRD4chr19

15367984

-
Frame-shiftENST00000269701ENST00000360016AKAP8chr19

15487787

-BRD4chr19

15366403

-
Frame-shiftENST00000269701ENST00000371835AKAP8chr19

15487787

-BRD4chr19

15367984

-
Frame-shiftENST00000269701ENST00000371835AKAP8chr19

15487787

-BRD4chr19

15366403

-
In-frameENST00000269701ENST00000263377AKAP8chr19

15490524

-BRD4chr19

15367984

-
In-frameENST00000269701ENST00000360016AKAP8chr19

15490524

-BRD4chr19

15367984

-
In-frameENST00000269701ENST00000371835AKAP8chr19

15490524

-BRD4chr19

15367984

-
intron-3UTRENST00000269701ENST00000371835AKAP8chr19

15465385

-BRD4chr19

15359824

-
intron-intronENST00000269701ENST00000263377AKAP8chr19

15465385

-BRD4chr19

15359824

-
intron-intronENST00000269701ENST00000360016AKAP8chr19

15465385

-BRD4chr19

15359824

-
intron-intronENST00000269701ENST00000602230AKAP8chr19

15465385

-BRD4chr19

15359824

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000269701AKAP8chr1915490524-ENST00000263377BRD4chr1915367984-436980142827937
ENST00000269701AKAP8chr1915490524-ENST00000371835BRD4chr1915367984-31318014907297
ENST00000269701AKAP8chr1915490524-ENST00000360016BRD4chr1915367984-168980141123369

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000269701ENST00000263377AKAP8chr1915490524-BRD4chr1915367984-0.0109304120.98906964
ENST00000269701ENST00000371835AKAP8chr1915490524-BRD4chr1915367984-0.003725810.99627423
ENST00000269701ENST00000360016AKAP8chr1915490524-BRD4chr1915367984-0.0079030140.992097

Top

Fusion Genomic Features for AKAP8-BRD4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for AKAP8-BRD4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:15465385/chr19:15359824)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AKAP8

O43823

BRD4

O60885

FUNCTION: Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (PubMed:9473338). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring (PubMed:10601332, PubMed:10791967, PubMed:11964380). May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression (PubMed:14641107). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L (PubMed:16980585). Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation (PubMed:22130794). May be involved in regulation of DNA replication by acting as scaffold for MCM2 (PubMed:12740381). Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation (PubMed:23995757). May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells (PubMed:16227597). May act as a carrier protein of GJA1 for its transport to the nucleus (PubMed:26880274). May play a repressive role in the regulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro. In cells, associates with ribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter and transcribed regions (PubMed:26683827). Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (By similarity). {ECO:0000250|UniProtKB:Q63014, ECO:0000250|UniProtKB:Q9DBR0, ECO:0000269|PubMed:10601332, ECO:0000269|PubMed:10791967, ECO:0000269|PubMed:11964380, ECO:0000269|PubMed:16980585, ECO:0000269|PubMed:22130794, ECO:0000269|PubMed:26683827, ECO:0000269|PubMed:26880274, ECO:0000305|PubMed:14641107, ECO:0000305|PubMed:9473338}.FUNCTION: Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:23589332, PubMed:23317504, PubMed:22334664). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters. Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6. BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (PubMed:23589332, PubMed:19596240, PubMed:16109377, PubMed:16109376, PubMed:24360279). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:23086925). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B (PubMed:19103749). Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (PubMed:23317504). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:19596240, ECO:0000269|PubMed:22334664, ECO:0000269|PubMed:22509028, ECO:0000269|PubMed:23086925, ECO:0000269|PubMed:23317504, ECO:0000269|PubMed:23589332, ECO:0000269|PubMed:24360279}.; FUNCTION: [Isoform B]: Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AX/H2A.x phosphorylation. {ECO:0000269|PubMed:23728299}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBRD4chr19:15490524chr19:15367984ENST000002633776201011_10144471363.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST000002633776201028_10334471363.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST000002633776201283_13004471363.0Compositional biasNote=Poly-Gln
TgeneBRD4chr19:15490524chr19:15367984ENST000002633776201301_13084471363.0Compositional biasNote=Poly-Ala
TgeneBRD4chr19:15490524chr19:15367984ENST000002633776201335_13384471363.0Compositional biasNote=Poly-Arg
TgeneBRD4chr19:15490524chr19:15367984ENST00000263377620535_5944471363.0Compositional biasNote=Lys-rich
TgeneBRD4chr19:15490524chr19:15367984ENST00000263377620692_7174471363.0Compositional biasNote=Ser-rich
TgeneBRD4chr19:15490524chr19:15367984ENST00000263377620703_7144471363.0Compositional biasNote=Poly-Ser
TgeneBRD4chr19:15490524chr19:15367984ENST00000263377620738_7434471363.0Compositional biasNote=Poly-His
TgeneBRD4chr19:15490524chr19:15367984ENST00000263377620757_7614471363.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST00000263377620764_7704471363.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST00000263377620771_7754471363.0Compositional biasNote=Poly-Gln
TgeneBRD4chr19:15490524chr19:15367984ENST00000263377620776_7834471363.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST00000263377620954_9644471363.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST00000263377620974_9864471363.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST000003600166121011_1014447795.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST000003600166121028_1033447795.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST000003600166121283_1300447795.0Compositional biasNote=Poly-Gln
TgeneBRD4chr19:15490524chr19:15367984ENST000003600166121301_1308447795.0Compositional biasNote=Poly-Ala
TgeneBRD4chr19:15490524chr19:15367984ENST000003600166121335_1338447795.0Compositional biasNote=Poly-Arg
TgeneBRD4chr19:15490524chr19:15367984ENST00000360016612535_594447795.0Compositional biasNote=Lys-rich
TgeneBRD4chr19:15490524chr19:15367984ENST00000360016612692_717447795.0Compositional biasNote=Ser-rich
TgeneBRD4chr19:15490524chr19:15367984ENST00000360016612703_714447795.0Compositional biasNote=Poly-Ser
TgeneBRD4chr19:15490524chr19:15367984ENST00000360016612738_743447795.0Compositional biasNote=Poly-His
TgeneBRD4chr19:15490524chr19:15367984ENST00000360016612757_761447795.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST00000360016612764_770447795.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST00000360016612771_775447795.0Compositional biasNote=Poly-Gln
TgeneBRD4chr19:15490524chr19:15367984ENST00000360016612776_783447795.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST00000360016612954_964447795.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST00000360016612974_986447795.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST000003718356121011_1014447723.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST000003718356121028_1033447723.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST000003718356121283_1300447723.0Compositional biasNote=Poly-Gln
TgeneBRD4chr19:15490524chr19:15367984ENST000003718356121301_1308447723.0Compositional biasNote=Poly-Ala
TgeneBRD4chr19:15490524chr19:15367984ENST000003718356121335_1338447723.0Compositional biasNote=Poly-Arg
TgeneBRD4chr19:15490524chr19:15367984ENST00000371835612535_594447723.0Compositional biasNote=Lys-rich
TgeneBRD4chr19:15490524chr19:15367984ENST00000371835612692_717447723.0Compositional biasNote=Ser-rich
TgeneBRD4chr19:15490524chr19:15367984ENST00000371835612703_714447723.0Compositional biasNote=Poly-Ser
TgeneBRD4chr19:15490524chr19:15367984ENST00000371835612738_743447723.0Compositional biasNote=Poly-His
TgeneBRD4chr19:15490524chr19:15367984ENST00000371835612757_761447723.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST00000371835612764_770447723.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST00000371835612771_775447723.0Compositional biasNote=Poly-Gln
TgeneBRD4chr19:15490524chr19:15367984ENST00000371835612776_783447723.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST00000371835612954_964447723.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST00000371835612974_986447723.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST00000263377620600_6824471363.0DomainNET
TgeneBRD4chr19:15490524chr19:15367984ENST00000360016612600_682447795.0DomainNET
TgeneBRD4chr19:15490524chr19:15367984ENST00000371835612600_682447723.0DomainNET
TgeneBRD4chr19:15490524chr19:15367984ENST000002633776201047_13624471363.0RegionNote=C-terminal (CTD) region
TgeneBRD4chr19:15490524chr19:15367984ENST00000263377620484_5034471363.0RegionNote=NPS region
TgeneBRD4chr19:15490524chr19:15367984ENST00000263377620524_5794471363.0RegionNote=BID region
TgeneBRD4chr19:15490524chr19:15367984ENST000003600166121047_1362447795.0RegionNote=C-terminal (CTD) region
TgeneBRD4chr19:15490524chr19:15367984ENST00000360016612484_503447795.0RegionNote=NPS region
TgeneBRD4chr19:15490524chr19:15367984ENST00000360016612524_579447795.0RegionNote=BID region
TgeneBRD4chr19:15490524chr19:15367984ENST000003718356121047_1362447723.0RegionNote=C-terminal (CTD) region
TgeneBRD4chr19:15490524chr19:15367984ENST00000371835612484_503447723.0RegionNote=NPS region
TgeneBRD4chr19:15490524chr19:15367984ENST00000371835612524_579447723.0RegionNote=BID region

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAKAP8chr19:15490524chr19:15367984ENST00000269701-114107_1186693.0Compositional biasNote=Poly-Gly
HgeneAKAP8chr19:15490524chr19:15367984ENST00000269701-114289_3066693.0MotifBipartite nuclear localization signal
HgeneAKAP8chr19:15490524chr19:15367984ENST00000269701-114387_4506693.0RegionInvolved in chromatin-binding
HgeneAKAP8chr19:15490524chr19:15367984ENST00000269701-114525_5696693.0RegionInvolved in condensin complex recruitment
HgeneAKAP8chr19:15490524chr19:15367984ENST00000269701-114572_5896693.0RegionRII-binding
HgeneAKAP8chr19:15490524chr19:15367984ENST00000269701-114392_4146693.0Zinc fingerC2H2 AKAP95-type 1
HgeneAKAP8chr19:15490524chr19:15367984ENST00000269701-114481_5046693.0Zinc fingerC2H2 AKAP95-type 2
TgeneBRD4chr19:15490524chr19:15367984ENST00000263377620368_4404471363.0DomainBromo 2
TgeneBRD4chr19:15490524chr19:15367984ENST0000026337762075_1474471363.0DomainBromo 1
TgeneBRD4chr19:15490524chr19:15367984ENST00000360016612368_440447795.0DomainBromo 2
TgeneBRD4chr19:15490524chr19:15367984ENST0000036001661275_147447795.0DomainBromo 1
TgeneBRD4chr19:15490524chr19:15367984ENST00000371835612368_440447723.0DomainBromo 2
TgeneBRD4chr19:15490524chr19:15367984ENST0000037183561275_147447723.0DomainBromo 1


Top

Fusion Gene Sequence for AKAP8-BRD4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3365_3365_1_AKAP8-BRD4_AKAP8_chr19_15490524_ENST00000269701_BRD4_chr19_15367984_ENST00000263377_length(transcript)=4369nt_BP=80nt
TGAACGCATGCGTGCTGTGGTCGCCTAGTAAACGGGGCTGCTGGTGGGCCGCGTCGAAGACATGGACCAGGGCTACGGAGGATGTGTTCG
AAATGCGCTTTGCCAAGATGCCGGACGAGCCTGAGGAGCCAGTGGTGGCCGTGTCCTCCCCGGCAGTGCCCCCTCCCACCAAGGTTGTGG
CCCCGCCCTCATCCAGCGACAGCAGCAGCGATAGCTCCTCGGACAGTGACAGTTCGACTGATGACTCTGAGGAGGAGCGAGCCCAGCGGC
TGGCTGAGCTCCAGGAGCAGCTCAAAGCCGTGCACGAGCAGCTTGCAGCCCTCTCTCAGCCCCAGCAGAACAAACCAAAGAAAAAGGAGA
AAGACAAGAAGGAAAAGAAAAAAGAAAAGCACAAAAGGAAAGAGGAAGTGGAAGAGAATAAAAAAAGCAAAGCCAAGGAACCTCCTCCTA
AAAAGACGAAGAAAAATAATAGCAGCAACAGCAATGTGAGCAAGAAGGAGCCAGCGCCCATGAAGAGCAAGCCCCCTCCCACGTATGAGT
CGGAGGAAGAGGACAAGTGCAAGCCTATGTCCTATGAGGAGAAGCGGCAGCTCAGCTTGGACATCAACAAGCTCCCCGGCGAGAAGCTGG
GCCGCGTGGTGCACATCATCCAGTCACGGGAGCCCTCCCTGAAGAATTCCAACCCCGACGAGATTGAAATCGACTTTGAGACCCTGAAGC
CGTCCACACTGCGTGAGCTGGAGCGCTATGTCACCTCCTGTTTGCGGAAGAAAAGGAAACCTCAAGCTGAGAAAGTTGATGTGATTGCCG
GCTCCTCCAAGATGAAGGGCTTCTCGTCCTCAGAGTCGGAGAGCTCCAGTGAGTCCAGCTCCTCTGACAGCGAAGACTCCGAAACAGAGA
TGGCTCCGAAGTCAAAAAAGAAGGGGCACCCCGGGAGGGAGCAGAAGAAGCACCATCATCACCACCATCAGCAGATGCAGCAGGCCCCGG
CTCCTGTGCCCCAGCAGCCGCCCCCGCCTCCCCAGCAGCCCCCACCGCCTCCACCTCCGCAGCAGCAACAGCAGCCGCCACCCCCGCCTC
CCCCACCCTCCATGCCGCAGCAGGCAGCCCCGGCGATGAAGTCCTCGCCCCCACCCTTCATTGCCACCCAGGTGCCCGTCCTGGAGCCCC
AGCTCCCAGGCAGCGTCTTTGACCCCATCGGCCACTTCACCCAGCCCATCCTGCACCTGCCGCAGCCTGAGCTGCCCCCTCACCTGCCCC
AGCCGCCTGAGCACAGCACTCCACCCCATCTCAACCAGCACGCAGTGGTCTCTCCTCCAGCTTTGCACAACGCACTACCCCAGCAGCCAT
CACGGCCCAGCAACCGAGCCGCTGCCCTGCCTCCCAAGCCCGCCCGGCCCCCAGCCGTGTCACCAGCCTTGACCCAAACACCCCTGCTCC
CACAGCCCCCCATGGCCCAACCCCCCCAAGTGCTGCTGGAGGATGAAGAGCCACCTGCCCCACCCCTCACCTCCATGCAGATGCAGCTGT
ACCTGCAGCAGCTGCAGAAGGTGCAGCCCCCTACGCCGCTACTCCCTTCCGTGAAGGTGCAGTCCCAGCCCCCACCCCCCCTGCCGCCCC
CACCCCACCCCTCTGTGCAGCAGCAGCTGCAGCAGCAGCCGCCACCACCCCCACCACCCCAGCCCCAGCCTCCACCCCAGCAGCAGCATC
AGCCCCCTCCACGGCCCGTGCACTTGCAGCCCATGCAGTTTTCCACCCACATCCAACAGCCCCCGCCACCCCAGGGCCAGCAGCCCCCCC
ATCCGCCCCCAGGCCAGCAGCCACCCCCGCCGCAGCCTGCCAAGCCTCAGCAAGTCATCCAGCACCACCATTCACCCCGGCACCACAAGT
CGGACCCCTACTCAACCGGTCACCTCCGCGAAGCCCCCTCCCCGCTTATGATACATTCCCCCCAGATGTCACAGTTCCAGAGCCTGACCC
ACCAGTCTCCACCCCAGCAAAACGTCCAGCCTAAGAAACAGGAGCTGCGTGCTGCCTCCGTGGTCCAGCCCCAGCCCCTCGTGGTGGTGA
AGGAGGAGAAGATCCACTCACCCATCATCCGCAGCGAGCCCTTCAGCCCCTCGCTGCGGCCGGAGCCCCCCAAGCACCCGGAGAGCATCA
AGGCCCCCGTCCACCTGCCCCAGCGGCCGGAAATGAAGCCTGTGGATGTCGGGAGGCCTGTGATCCGGCCCCCAGAGCAGAACGCACCGC
CACCAGGGGCCCCTGACAAGGACAAACAGAAACAGGAGCCGAAGACTCCAGTTGCGCCCAAAAAGGACCTGAAAATCAAGAACATGGGCT
CCTGGGCCAGCCTAGTGCAGAAGCATCCGACCACCCCCTCCTCCACAGCCAAGTCATCCAGCGACAGCTTCGAGCAGTTCCGCCGCGCCG
CTCGGGAGAAAGAGGAGCGTGAGAAGGCCCTGAAGGCTCAGGCCGAGCACGCTGAGAAGGAGAAGGAGCGGCTGCGGCAGGAGCGCATGA
GGAGCCGAGAGGACGAGGATGCGCTGGAGCAGGCCCGGCGGGCCCATGAGGAGGCACGTCGGCGCCAGGAGCAGCAGCAGCAGCAGCGCC
AGGAGCAACAGCAGCAGCAGCAACAGCAAGCAGCTGCGGTGGCTGCCGCCGCCACCCCACAGGCCCAGAGCTCCCAGCCCCAGTCCATGC
TGGACCAGCAGAGGGAGTTGGCCCGGAAGCGGGAGCAGGAGCGAAGACGCCGGGAAGCCATGGCAGCTACCATTGACATGAATTTCCAGA
GTGATCTATTGTCAATATTTGAAGAAAATCTTTTCTGAGCGCACCTAGGTGGCTTCTGACTTTGATTTTCTGGCAAAACATTGACTTTCC
ATAGTGTTAGGGGCGGTGGTGGAGGTGGGATCAGCGGCCAGGGGATGCCTCAGGGCCTGGCCCTCCTGCATGCTATGCCCGGGGCAGGCC
TGACGGGCAGCTGAGGATTGCAGAGCCTGTCTGCCTTACGGCCAGTCGGACAGACGTCCCGCCACCCACCACCCCTCACAGGACGTCCGC
TCAGCACACGCCTTGTTACGAGCAAGTGCCGGCTGGACCCAAGCCCTGCATCCCCACATGCGGGGCAGAGGCCCTTCTCTCCGCCAAATG
TCTACACAGTATACACAGGACATCGTTGCTGCCGCCGTGACTGGTTTTCTGTCCCCAAGAACGTGACGTTCGTGATGTCCTGCCCGCCGG
GAGTCTTTCCCCACACCCCAGCCATCGCCGCCCGCTCCCAGGAGGCCAGGGCAGGCCTGCGTGGGCTGGAGGCGGGCGAGGCCGGCCCAC
CCCCTCGCTGGCACTGACTTTGCCTTGAACAGACCCCCCGACCCTCCCCCACAAGCCTTTAATTGAGAGCCGCTCTCTGTAAGTGTTTGC
TTGTGCAAAAGGGAATAGTGCCGTGGAGGTGTGTGTGTCCATGGCATCCGGAGCGAGGCGACTGTCCTGCGTGGGTAGCCCTCGGCCGGG
GAGTGAGGCCACCAACCAAAGTCAGTTCCTTCCCACCTGTGTTTCTGTTTCGTTTTTTTTTTTCTTTTTTTTCTATATATATTTTTTGTT
GAATTCTATTTTATTTTTAATTCTCTCTTCTCCTCCAGACACAATGGCACTGCTTATCTCCGAAATGGTGTGATCGTCTCCTCATTGAGC
AGCGGCTGCCACCGCGCTGTGGGTAGTGTGTGACCGTGGCTGTACTGTATAGTGAACATAGTTGGCATATCTTTGTTTGAAGTTTGTTGG
TGACTCCACCAAACTGGTGTGAAAAAAGAAAAAAGCTCAAAAAAATCCACAAAAAGACAAAACACACAAAAAAAATCCTGCCTATATTTT
ACTCAGTTTCAAACTTTATTAGTCTATTTTTAATTATAAAACCAGAAAGCTACAATTTCTTTTCTTTCCCCTCCACCCCCCCCCCCCCCA
CCCATTTGTTGGCTTTTTTGTTTTTTAATGTCAGATCTGTTGAGTTGGTTTTTTTGGTTTTGGTTTTTGTTTTTGTTTTTGTTTTTTACT
GAGAAAGGAAGGGCCAAGGGATGAGGTGGGAACCGGGCCCTGGGGGCGCCACAGACTAAGGCAGAGACTCCCCTACCTGGCGCCCAGCCC
CAACCAGCTGGCCGCTCCTGCCCATGCTTTTTTTTTTTTTTTTTTTTAATTTTTATAATTGGAGCCCCTGGTGAGGTTACGCGTGCCATG
AGAACCCACTCTACACCACGACGCTGGTGCCTCAGTGTTGGCCAAACTCTGGAGTCACTGACTGGTTTGACTTTCATACGGTGAATATGC

>3365_3365_1_AKAP8-BRD4_AKAP8_chr19_15490524_ENST00000269701_BRD4_chr19_15367984_ENST00000263377_length(amino acids)=937AA_BP=547
MWSPSKRGCWWAASKTWTRATEDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQ
EQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYESEEED
KCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKM
KGFSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPPPPPSM
PQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLPQPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSN
RAAALPPKPARPPAVSPALTQTPLLPQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPPPPHPS
VQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPPHPPPGQQPPPPQPAKPQQVIQHHHSPRHHKSDPYS
TGHLREAPSPLMIHSPQMSQFQSLTHQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEPFSPSLRPEPPKHPESIKAPVH
LPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMGSWASLVQKHPTTPSSTAKSSSDSFEQFRRAAREKE
EREKALKAQAEHAEKEKERLRQERMRSREDEDALEQARRAHEEARRRQEQQQQQRQEQQQQQQQQAAAVAAAATPQAQSSQPQSMLDQQR

--------------------------------------------------------------
>3365_3365_2_AKAP8-BRD4_AKAP8_chr19_15490524_ENST00000269701_BRD4_chr19_15367984_ENST00000360016_length(transcript)=1689nt_BP=80nt
TGAACGCATGCGTGCTGTGGTCGCCTAGTAAACGGGGCTGCTGGTGGGCCGCGTCGAAGACATGGACCAGGGCTACGGAGGATGTGTTCG
AAATGCGCTTTGCCAAGATGCCGGACGAGCCTGAGGAGCCAGTGGTGGCCGTGTCCTCCCCGGCAGTGCCCCCTCCCACCAAGGTTGTGG
CCCCGCCCTCATCCAGCGACAGCAGCAGCGATAGCTCCTCGGACAGTGACAGTTCGACTGATGACTCTGAGGAGGAGCGAGCCCAGCGGC
TGGCTGAGCTCCAGGAGCAGCTCAAAGCCGTGCACGAGCAGCTTGCAGCCCTCTCTCAGCCCCAGCAGAACAAACCAAAGAAAAAGGAGA
AAGACAAGAAGGAAAAGAAAAAAGAAAAGCACAAAAGGAAAGAGGAAGTGGAAGAGAATAAAAAAAGCAAAGCCAAGGAACCTCCTCCTA
AAAAGACGAAGAAAAATAATAGCAGCAACAGCAATGTGAGCAAGAAGGAGCCAGCGCCCATGAAGAGCAAGCCCCCTCCCACGTATGAGT
CGGAGGAAGAGGACAAGTGCAAGCCTATGTCCTATGAGGAGAAGCGGCAGCTCAGCTTGGACATCAACAAGCTCCCCGGCGAGAAGCTGG
GCCGCGTGGTGCACATCATCCAGTCACGGGAGCCCTCCCTGAAGAATTCCAACCCCGACGAGATTGAAATCGACTTTGAGACCCTGAAGC
CGTCCACACTGCGTGAGCTGGAGCGCTATGTCACCTCCTGTTTGCGGAAGAAAAGGAAACCTCAAGCTGAGAAAGTTGATGTGATTGCCG
GCTCCTCCAAGATGAAGGGCTTCTCGTCCTCAGAGTCGGAGAGCTCCAGTGAGTCCAGCTCCTCTGACAGCGAAGACTCCGAAACAGCTT
TCTGCACCAGTGGAGACTTCGTGTCCCCAGGGCCTTCCCCGTATCACAGTCACGTGCAGTGCGGCCGCTTCAGGGAGATGCTTCGCTGGT
TTCTGGTGGATGTGGAGCAGACTGCAGCTGGCCAGCCGCATCGCCAGTCTGCTGCTGGCCCTGCCATCACCTGGGCCCCAGCCATTGCCT
ACCCCTCCCCAGAGTGTGCTCGTTGCTGTGTTGGCTGCTCCTGAATCTGCCCTAACTCCACACGCACCTGGACTTGCGTGTCCCTCCTGC
AGTTCTAACTAACAGTCCCTTCTTTTCAAGCCCCGTGGGTCTGCACGTTGGACCCTGGGTTCCCCATTAGAGCCCACCTTCTGAGCAGCA
GCCTCAGTGGGAGGTGGAGGCAGGTAGTGATGCTGGGTGCCAGGTGGGAGTGGAGAGGGGACTGCTCTCCTCCAAGTGTGCACTTTCCTC
ATTATTCTCAGGGGCGCAGATGCTCAGGCTGGCGCAGGGGAGAGGCTAGGGAGGGAGCCATGGTGCCCAGAAGGCCTGGCGACCAGCCCC
TGCTGAGAGATGGAGCTAACATCCTGTGTTTACGGCCAACGGGGTTGCCGCTAGGCTGGTGCAGCTGTCAGTGAGCTGGCGTGCTGCAGA
CCACCTGAGAGCTGGCCCTAGGGTCTCAGGCAGACTGGGGAGTGGGGATCCACAGTGGGAAACCTGTGTTTTGGCAGTAGACTCCTGCAT

>3365_3365_2_AKAP8-BRD4_AKAP8_chr19_15490524_ENST00000269701_BRD4_chr19_15367984_ENST00000360016_length(amino acids)=369AA_BP=1
MWSPSKRGCWWAASKTWTRATEDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQ
EQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYESEEED
KCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKM
KGFSSSESESSSESSSSDSEDSETAFCTSGDFVSPGPSPYHSHVQCGRFREMLRWFLVDVEQTAAGQPHRQSAAGPAITWAPAIAYPSPE

--------------------------------------------------------------
>3365_3365_3_AKAP8-BRD4_AKAP8_chr19_15490524_ENST00000269701_BRD4_chr19_15367984_ENST00000371835_length(transcript)=3131nt_BP=80nt
TGAACGCATGCGTGCTGTGGTCGCCTAGTAAACGGGGCTGCTGGTGGGCCGCGTCGAAGACATGGACCAGGGCTACGGAGGATGTGTTCG
AAATGCGCTTTGCCAAGATGCCGGACGAGCCTGAGGAGCCAGTGGTGGCCGTGTCCTCCCCGGCAGTGCCCCCTCCCACCAAGGTTGTGG
CCCCGCCCTCATCCAGCGACAGCAGCAGCGATAGCTCCTCGGACAGTGACAGTTCGACTGATGACTCTGAGGAGGAGCGAGCCCAGCGGC
TGGCTGAGCTCCAGGAGCAGCTCAAAGCCGTGCACGAGCAGCTTGCAGCCCTCTCTCAGCCCCAGCAGAACAAACCAAAGAAAAAGGAGA
AAGACAAGAAGGAAAAGAAAAAAGAAAAGCACAAAAGGAAAGAGGAAGTGGAAGAGAATAAAAAAAGCAAAGCCAAGGAACCTCCTCCTA
AAAAGACGAAGAAAAATAATAGCAGCAACAGCAATGTGAGCAAGAAGGAGCCAGCGCCCATGAAGAGCAAGCCCCCTCCCACGTATGAGT
CGGAGGAAGAGGACAAGTGCAAGCCTATGTCCTATGAGGAGAAGCGGCAGCTCAGCTTGGACATCAACAAGCTCCCCGGCGAGAAGCTGG
GCCGCGTGGTGCACATCATCCAGTCACGGGAGCCCTCCCTGAAGAATTCCAACCCCGACGAGATTGAAATCGACTTTGAGACCCTGAAGC
CGTCCACACTGCGTGAGCTGGAGCGCTATGTCACCTCCTGTTTGCGGAAGAAAAGGAAACCTCAAGCTGAGAAAGTTGATGTGATTGCCG
GCTCCTCCAAGATGAAGGGCTTCTCGTCCTCAGAGTCGGAGAGCTCCAGTGAGTCCAGCTCCTCTGACAGCGAAGACTCCGAAACAGGTC
CTGCCTAATCATTGGACACGGACTCTTAATAAAACGGTCTTCAGTTCCAGATTCCTTCCCAGCAAGCTATAGCTTAAGTCCATTTTCTTC
CGTGAAAGGGACAGGACTCCATCAAGTTATGGAATTCCTCAGAGCCCTGGGCCTGTCCCCCGGGGTGGATTAGTCATGTCCAGCAGCACA
CGCCTAGTCCCGCCTTCGGGAAGGCTGCCTGCCTGGCCAGCCGCCCAGGCCTCTCTGTGTAAAGACTGCCTGGCTGTCCTGCCCAGCCTT
CCTGGTTCTCTGGGGTCCTCTGGGTGGGTGGCATCTCCTGGAGGGTGATGACAATCCCCAACACATGCATTCATGTGGTGCTACTCTGTG
TGCAAAGCCAGACCCCAAGTATGTTTTCTCTCTTTGTCCCATCCCTCTTTTTCTGGGACTTTGGACCCTAACTACTTCCCTCCTGAACCT
TGCAGTGACATCAGTCCAGGAGAGCTCTCGTTCAGTGTGCGGAAGAACACTCTGACCTCTAGAGCTGTCCTAGATAAGGAGTGGGAGCTT
TAGAGGCAAGGCCTCTAGACCCTGGAAGGCTCAGTGAGGCTCTTCCCACAGCATGCTTCTCACTGGTGCCCTGTAAGGCTCGAGCCACCG
CTGACTCTGAGCCTTTTGGAGTCTTTCCTCCTTCGTCTCCATTGTTCCCGTGCATTTCCAAAAGCTTAAGTTGCCTGGTGGGCATTTCCC
CAGTTTCTTTGGCCTCCGTCTTCTCAAGTCACATAGGGAAAGTACCTCCTGGAACCAGGCTGCAGTATGCAGGACCTGCCAGGCAGGCAC
TGGTGAAGGGCCTTGGGCCTATCATCCCCCCAACCCCACCTCACCCCACCCGCCTCCTCTAGTGGGGTGAGTCTGGGCTGGTGGACCAGA
GAGGGTGTCACAGACCCTCAGGGACTGCCCCATGGACACCTCTGACTGGTGTTAACAGTGTGAACATTTTCCCCGTCTTCAGTCCCTTAG
AATGACGACAGCCCCTGGGGTTGGGGCAGGCGAGTGTGGCCACATCATCCAAGCCCTCCCAGAGACACAAATAGGCTTTTTTGCTCTAAA
AATAAATACCAGCCCTTTTTTGGTCACAAATCCAGCATCTCAGCAGAAAACTGCCTGACATGAAAAGTCCCCTGAGGAACTGCATCTGCG
TTTCAGGGGCTTTTCATTTTTTCTCCTTTTTTAAAGTGTAGATTGTGGGTGCTTCCTAGAGGCCTGCCTTCTTCTGGAACTGGAAGTGGG
CTATCACCATGGGCAAGCCCTTGGGTGCAGGCTCCCCACCTGCCTGGGAACTCTGGCAGCTCTCCTCAGCTCCTTGGGCTTGAGCAGCTG
CAACTGCCCCAGATTTGCTGTGGAAGCAGGGGCTAGCCCTGGCCTCACCAGGGCCTCCCGGGGCCCTGCATTGATGCTCAGGAGTTCCTG
GGCTGCTCTTGATCCTTTCTGGGCATCCAGCTTCCAGTTAAGCTCTGTTTGCCAAACAAACTATTCTCAGCTGCCCTTTGGCCTGCGCCT
GATGTGTTCCTGTTGCAGTCCCGCCTGCCTGAGACAGGAGCAGGCAGGAGAGCCTTCATGCCCAGATTCCCACAGGACAATTGGGGAGCT
GCTGGCATTGTCTTTCTGGGAAGATTCTGCTTTCTTGGACCAAATGGCAGCCTGATTACCAGTGTCGGGCCTGCATGCTGCCCCCGACAC
ACGCACGCACGCGCACACACGTGTGCACATGGGCCATAGCCACAAGCCAGCTCTCCTCCAGGGTCCTTTCAACCTCGCTGTCCAGGGACC
CTGTCCTTCTTGCCCGTGGGGCTTCCATCTGGCAGAGAACGTTCAGGGCTTGTTGAACTTGAAAGCTCATTAGACTTAAGCTGTCACCTG
TGCTTGGTGCCCCAGGAACAGCCAGAGAGGACAGTGCCCACTCACTTCTTGTTGGCAGCCTCCTGTGCAGGAAGTGCCAGCCGGGCCTCG
ACGCACCAGCTGGCTGTGGGTCCTGAGGAGGGGCGGGAGGCGGCCGCTCAGTGCAGATGGGGACTCCTCTCCTCTGCCCTGACCTTACCC
TCCATTACCTCCTTCACTGGAGTGGGGCTGGGGGGTGGGTGGAATCAGTGTTTTAATCGGATTTTTAAAAAACATTTTATTTCTTTGTAC

>3365_3365_3_AKAP8-BRD4_AKAP8_chr19_15490524_ENST00000269701_BRD4_chr19_15367984_ENST00000371835_length(amino acids)=297AA_BP=1
MWSPSKRGCWWAASKTWTRATEDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQ
EQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYESEEED
KCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKM

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for AKAP8-BRD4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneAKAP8chr19:15490524chr19:15367984ENST00000269701-114109_2016.333333333333333693.0DDX5
HgeneAKAP8chr19:15490524chr19:15367984ENST00000269701-1141_2106.333333333333333693.0DPY30
HgeneAKAP8chr19:15490524chr19:15367984ENST00000269701-1141_1956.333333333333333693.0MCM2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for AKAP8-BRD4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for AKAP8-BRD4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource