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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:GNB3-METAP2 (FusionGDB2 ID:33712) |
Fusion Gene Summary for GNB3-METAP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: GNB3-METAP2 | Fusion gene ID: 33712 | Hgene | Tgene | Gene symbol | GNB3 | METAP2 | Gene ID | 2784 | 10988 |
| Gene name | G protein subunit beta 3 | methionyl aminopeptidase 2 | |
| Synonyms | CSNB1H | MAP2|MNPEP|p67eIF2 | |
| Cytomap | 12p13.31 | 12q22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3G protein, beta-3 subunitGTP-binding regulatory protein beta-3 chainguanine nucleotide binding protein (G protein), beta polypeptide 3guanine nucleotide-binding protein G(I)/G(S)/G(T) bet | methionine aminopeptidase 2eIF-2-associated p67 homologinitiation factor 2-associated 67 kDa glycoproteinpeptidase M 2testicular tissue protein Li 17 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | P50579 | |
| Ensembl transtripts involved in fusion gene | ENST00000229264, ENST00000435982, | ENST00000550777, ENST00000551840, ENST00000261220, ENST00000323666, ENST00000546753, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 6 X 3=108 |
| # samples | 1 | 6 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: GNB3 [Title/Abstract] AND METAP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | GNB3(6954966)-METAP2(95869847), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | METAP2 | GO:0016485 | protein processing | 8858118 |
| Tgene | METAP2 | GO:0018206 | peptidyl-methionine modification | 8858118 |
| Tgene | METAP2 | GO:0031365 | N-terminal protein amino acid modification | 8858118 |
| Fusion gene breakpoints across GNB3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across METAP2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | GBM | TCGA-06-0129-01A | GNB3 | chr12 | 6954966 | + | METAP2 | chr12 | 95869847 | + |
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Fusion Gene ORF analysis for GNB3-METAP2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000229264 | ENST00000550777 | GNB3 | chr12 | 6954966 | + | METAP2 | chr12 | 95869847 | + |
| 5CDS-intron | ENST00000229264 | ENST00000551840 | GNB3 | chr12 | 6954966 | + | METAP2 | chr12 | 95869847 | + |
| 5CDS-intron | ENST00000435982 | ENST00000550777 | GNB3 | chr12 | 6954966 | + | METAP2 | chr12 | 95869847 | + |
| 5CDS-intron | ENST00000435982 | ENST00000551840 | GNB3 | chr12 | 6954966 | + | METAP2 | chr12 | 95869847 | + |
| In-frame | ENST00000229264 | ENST00000261220 | GNB3 | chr12 | 6954966 | + | METAP2 | chr12 | 95869847 | + |
| In-frame | ENST00000229264 | ENST00000323666 | GNB3 | chr12 | 6954966 | + | METAP2 | chr12 | 95869847 | + |
| In-frame | ENST00000229264 | ENST00000546753 | GNB3 | chr12 | 6954966 | + | METAP2 | chr12 | 95869847 | + |
| In-frame | ENST00000435982 | ENST00000261220 | GNB3 | chr12 | 6954966 | + | METAP2 | chr12 | 95869847 | + |
| In-frame | ENST00000435982 | ENST00000323666 | GNB3 | chr12 | 6954966 | + | METAP2 | chr12 | 95869847 | + |
| In-frame | ENST00000435982 | ENST00000546753 | GNB3 | chr12 | 6954966 | + | METAP2 | chr12 | 95869847 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000229264 | GNB3 | chr12 | 6954966 | + | ENST00000323666 | METAP2 | chr12 | 95869847 | + | 4542 | 1321 | 396 | 2606 | 736 |
| ENST00000229264 | GNB3 | chr12 | 6954966 | + | ENST00000546753 | METAP2 | chr12 | 95869847 | + | 2933 | 1321 | 396 | 2537 | 713 |
| ENST00000229264 | GNB3 | chr12 | 6954966 | + | ENST00000261220 | METAP2 | chr12 | 95869847 | + | 2976 | 1321 | 396 | 2537 | 713 |
| ENST00000435982 | GNB3 | chr12 | 6954966 | + | ENST00000323666 | METAP2 | chr12 | 95869847 | + | 4224 | 1003 | 81 | 2288 | 735 |
| ENST00000435982 | GNB3 | chr12 | 6954966 | + | ENST00000546753 | METAP2 | chr12 | 95869847 | + | 2615 | 1003 | 81 | 2219 | 712 |
| ENST00000435982 | GNB3 | chr12 | 6954966 | + | ENST00000261220 | METAP2 | chr12 | 95869847 | + | 2658 | 1003 | 81 | 2219 | 712 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000229264 | ENST00000323666 | GNB3 | chr12 | 6954966 | + | METAP2 | chr12 | 95869847 | + | 0.000440869 | 0.9995591 |
| ENST00000229264 | ENST00000546753 | GNB3 | chr12 | 6954966 | + | METAP2 | chr12 | 95869847 | + | 0.001030607 | 0.99896944 |
| ENST00000229264 | ENST00000261220 | GNB3 | chr12 | 6954966 | + | METAP2 | chr12 | 95869847 | + | 0.000762496 | 0.99923754 |
| ENST00000435982 | ENST00000323666 | GNB3 | chr12 | 6954966 | + | METAP2 | chr12 | 95869847 | + | 0.000375008 | 0.99962497 |
| ENST00000435982 | ENST00000546753 | GNB3 | chr12 | 6954966 | + | METAP2 | chr12 | 95869847 | + | 0.000923479 | 0.9990765 |
| ENST00000435982 | ENST00000261220 | GNB3 | chr12 | 6954966 | + | METAP2 | chr12 | 95869847 | + | 0.00065562 | 0.9993444 |
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Fusion Genomic Features for GNB3-METAP2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| GNB3 | chr12 | 6954966 | + | METAP2 | chr12 | 95869849 | + | 8.66E-05 | 0.99991333 |
| GNB3 | chr12 | 6954966 | + | METAP2 | chr12 | 95869849 | + | 8.66E-05 | 0.99991333 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for GNB3-METAP2 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:6954966/chr12:95869847) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | METAP2 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.; FUNCTION: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | GNB3 | chr12:6954966 | chr12:95869847 | ENST00000229264 | + | 10 | 11 | 141_170 | 305 | 341.0 | Repeat | Note=WD 3 |
| Hgene | GNB3 | chr12:6954966 | chr12:95869847 | ENST00000229264 | + | 10 | 11 | 182_212 | 305 | 341.0 | Repeat | Note=WD 4 |
| Hgene | GNB3 | chr12:6954966 | chr12:95869847 | ENST00000229264 | + | 10 | 11 | 224_254 | 305 | 341.0 | Repeat | Note=WD 5 |
| Hgene | GNB3 | chr12:6954966 | chr12:95869847 | ENST00000229264 | + | 10 | 11 | 268_298 | 305 | 341.0 | Repeat | Note=WD 6 |
| Hgene | GNB3 | chr12:6954966 | chr12:95869847 | ENST00000229264 | + | 10 | 11 | 53_83 | 305 | 341.0 | Repeat | Note=WD 1 |
| Hgene | GNB3 | chr12:6954966 | chr12:95869847 | ENST00000229264 | + | 10 | 11 | 95_125 | 305 | 341.0 | Repeat | Note=WD 2 |
| Tgene | METAP2 | chr12:6954966 | chr12:95869847 | ENST00000323666 | 0 | 11 | 98_106 | 50 | 479.0 | Compositional bias | Note=Poly-Lys |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | GNB3 | chr12:6954966 | chr12:95869847 | ENST00000229264 | + | 10 | 11 | 310_340 | 305 | 341.0 | Repeat | Note=WD 7 |
| Tgene | METAP2 | chr12:6954966 | chr12:95869847 | ENST00000323666 | 0 | 11 | 41_46 | 50 | 479.0 | Compositional bias | Note=Poly-Lys |
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Fusion Gene Sequence for GNB3-METAP2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >33712_33712_1_GNB3-METAP2_GNB3_chr12_6954966_ENST00000229264_METAP2_chr12_95869847_ENST00000261220_length(transcript)=2976nt_BP=1321nt CCACAATAGGGGCAGACCTGTCCATCCTTCTCTGTGGGTCCCCTGTACCTTTCTCCCCCAACAGGATCAGACCCAGAGGCAGCTGGTTGG GGTTTGTCGAGAAGAAGGATTATCCAGATCAGTCCTTTCTAATCTCAGCTCCTGCCTGTACCCTCCCATACTCACCAAACCCTCTTCCCC ACCACCCTGAGCTGAGGAGCACAGTTTGAGGCCCCCCCAACCCCCCGCCGGTCGGGGCCAGGCCAGGCCAGGCCAGCTCCTCTGGCAGCA GAGCCTGGGCAGGTGACGGGCGGGCGCGGGCGTCGCAGCTGAGGGAGTAAGGAGGCTCCCAGGAACCGGAGCTGGAAACCCGGCCGAGGT CCAGCCAGAGCCCAAGAGCCAGAGTGACCCCTCGACCTGTCAGCCATGGGGGAGATGGAGCAACTGCGTCAGGAAGCGGAGCAGCTCAAG AAGCAGATTGCAGATGCCAGGAAAGCCTGTGCTGACGTTACTCTGGCAGAGCTGGTGTCTGGCCTAGAGGTGGTGGGACGAGTCCAGATG CGGACGCGGCGGACGTTAAGGGGACACCTGGCCAAGATTTACGCCATGCACTGGGCCACTGATTCTAAGCTGCTGGTAAGTGCCTCGCAA GATGGGAAGCTGATCGTGTGGGACAGCTACACCACCAACAAGGTGCACGCCATCCCACTGCGCTCCTCCTGGGTCATGACCTGTGCCTAT GCCCCATCAGGGAACTTTGTGGCATGTGGGGGGCTGGACAACATGTGTTCCATCTACAACCTCAAATCCCGTGAGGGCAATGTCAAGGTC AGCCGGGAGCTTTCTGCTCACACAGGTTATCTCTCCTGCTGCCGCTTCCTGGATGACAACAATATTGTGACCAGCTCGGGGGACACCACG TGTGCCTTGTGGGACATTGAGACTGGGCAGCAGAAGACTGTATTTGTGGGACACACGGGTGACTGCATGAGCCTGGCTGTGTCTCCTGAC TTCAATCTCTTCATTTCGGGGGCCTGTGATGCCAGTGCCAAGCTCTGGGATGTGCGAGAGGGGACCTGCCGTCAGACTTTCACTGGCCAC GAGTCGGACATCAACGCCATCTGTTTCTTCCCCAATGGAGAGGCCATCTGCACGGGCTCGGATGACGCTTCCTGCCGCTTGTTTGACCTG CGGGCAGACCAGGAGCTGATCTGCTTCTCCCACGAGAGCATCATCTGCGGCATCACGTCCGTGGCCTTCTCCCTCAGTGGCCGCCTACTA TTCGCTGGCTACGACGACTTCAACTGCAATGTCTGGGACTCCATGAAGTCTGAGCGTGTGGGGGAACAGGAACCTGATAAAGAATCAGGA GCCTCAGTGGATGAAGTAGCAAGACAGTTGGAAAGATCAGCATTGGAAGATAAAGAAAGAGATGAAGATGATGAAGCAAAAGTTCAAACA GACCCTCCCTCAGTTCCAATATGTGACCTGTATCCTAATGGTGTATTTCCCAAAGGACAAGAATGCGAATACCCACCCACACAAGATGGG CGAACAGCTGCTTGGAGAACTACAAGTGAAGAAAAGAAAGCATTAGATCAGGCAAGTGAAGAGATTTGGAATGATTTTCGAGAAGCTGCA GAAGCACATCGACAAGTTAGAAAATACGTAATGAGCTGGATCAAGCCTGGGATGACAATGATAGAAATCTGTGAAAAGTTGGAAGACTGT TCACGCAAGTTAATAAAAGAGAATGGATTAAATGCAGGCCTGGCATTTCCTACTGGATGTTCTCTCAATAATTGTGCTGCCCATTATACT CCCAATGCCGGTGACACAACAGTATTACAGTATGATGACATCTGTAAAATAGACTTTGGAACACATATAAGTGGTAGGATTATTGACTGT GCTTTTACTGTCACTTTTAATCCCAAATATGATACGTTATTAAAAGCTGTAAAAGATGCTACTAACACTGGAATAAAGTGTGCTGGAATT GATGTTCGTCTGTGTGATGTTGGTGAGGCCATCCAAGAAGTTATGGAGTCCTATGAAGTTGAAATAGATGGGAAGACATATCAAGTGAAA CCAATCCGTAATCTAAATGGACATTCAATTGGGCAATATAGAATACATGCTGGAAAAACAGTGCCGATTGTGAAAGGAGGGGAGGCAACA AGAATGGAGGAAGGAGAAGTATATGCAATTGAAACCTTTGGTAGTACAGGAAAAGGTGTTGTTCATGATGATATGGAATGTTCACATTAC ATGAAAAATTTTGATGTTGGACATGTGCCAATAAGGCTTCCAAGAACAAAACACTTGTTAAATGTCATCAATGAAAACTTTGGAACCCTT GCCTTCTGCCGCAGATGGCTGGATCGCTTGGGAGAAAGTAAATACTTGATGGCTCTGAAGAATCTGTGTGACTTGGGCATTGTAGATCCA TATCCACCATTATGTGACATTAAAGGATCATATACAGCGCAATTTGAACATACCATCCTGTTGCGTCCAACATGTAAAGAAGTTGTCAGC AGAGGAGATGACTATTAAACTTAGTCCAAAGCCACCTCAACACCTTTATTTTCTGAGCTTTGTTGGAAAACATGATACCAGAATTAATTT GCCACATGTTGTCTGTTTTAACAGTGGACCCATGTAATACTTTTATCCATGTTTAAAAAAGAAGGAATTTGGACAAAGGCAAACCGTCTA ATGTAATTAACCAACGAAAAAGCTTTCCGGACTTTTAAATGCTAACTGTTTTTCCCCTTCCTGTCTAGGAAAATGCTATAAAGCTCAAAT TAGTTAGGAATGACTTATACGTTTTGTTTTGAATACCTAAGAGATACTTTTTGGATATTTATATTGCCATATTCTTACTTGAATGCTTTG AATGACTACATCCAGTTCTGCACCTATACCCTCTGGTGTTGCTTTTTAACCTTCCTGGAATCCATTTTCTAAAAAATAAAGACATTTTCA >33712_33712_1_GNB3-METAP2_GNB3_chr12_6954966_ENST00000229264_METAP2_chr12_95869847_ENST00000261220_length(amino acids)=713AA_BP=308 MSAMGEMEQLRQEAEQLKKQIADARKACADVTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTT NKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQK TVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHE SIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGEQEPDKESGASVDEVARQLERSALEDKERDEDDEAKVQTDPPSVPICDLYP NGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNA GLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQ EVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIR -------------------------------------------------------------- >33712_33712_2_GNB3-METAP2_GNB3_chr12_6954966_ENST00000229264_METAP2_chr12_95869847_ENST00000323666_length(transcript)=4542nt_BP=1321nt CCACAATAGGGGCAGACCTGTCCATCCTTCTCTGTGGGTCCCCTGTACCTTTCTCCCCCAACAGGATCAGACCCAGAGGCAGCTGGTTGG GGTTTGTCGAGAAGAAGGATTATCCAGATCAGTCCTTTCTAATCTCAGCTCCTGCCTGTACCCTCCCATACTCACCAAACCCTCTTCCCC ACCACCCTGAGCTGAGGAGCACAGTTTGAGGCCCCCCCAACCCCCCGCCGGTCGGGGCCAGGCCAGGCCAGGCCAGCTCCTCTGGCAGCA GAGCCTGGGCAGGTGACGGGCGGGCGCGGGCGTCGCAGCTGAGGGAGTAAGGAGGCTCCCAGGAACCGGAGCTGGAAACCCGGCCGAGGT CCAGCCAGAGCCCAAGAGCCAGAGTGACCCCTCGACCTGTCAGCCATGGGGGAGATGGAGCAACTGCGTCAGGAAGCGGAGCAGCTCAAG AAGCAGATTGCAGATGCCAGGAAAGCCTGTGCTGACGTTACTCTGGCAGAGCTGGTGTCTGGCCTAGAGGTGGTGGGACGAGTCCAGATG CGGACGCGGCGGACGTTAAGGGGACACCTGGCCAAGATTTACGCCATGCACTGGGCCACTGATTCTAAGCTGCTGGTAAGTGCCTCGCAA GATGGGAAGCTGATCGTGTGGGACAGCTACACCACCAACAAGGTGCACGCCATCCCACTGCGCTCCTCCTGGGTCATGACCTGTGCCTAT GCCCCATCAGGGAACTTTGTGGCATGTGGGGGGCTGGACAACATGTGTTCCATCTACAACCTCAAATCCCGTGAGGGCAATGTCAAGGTC AGCCGGGAGCTTTCTGCTCACACAGGTTATCTCTCCTGCTGCCGCTTCCTGGATGACAACAATATTGTGACCAGCTCGGGGGACACCACG TGTGCCTTGTGGGACATTGAGACTGGGCAGCAGAAGACTGTATTTGTGGGACACACGGGTGACTGCATGAGCCTGGCTGTGTCTCCTGAC TTCAATCTCTTCATTTCGGGGGCCTGTGATGCCAGTGCCAAGCTCTGGGATGTGCGAGAGGGGACCTGCCGTCAGACTTTCACTGGCCAC GAGTCGGACATCAACGCCATCTGTTTCTTCCCCAATGGAGAGGCCATCTGCACGGGCTCGGATGACGCTTCCTGCCGCTTGTTTGACCTG CGGGCAGACCAGGAGCTGATCTGCTTCTCCCACGAGAGCATCATCTGCGGCATCACGTCCGTGGCCTTCTCCCTCAGTGGCCGCCTACTA TTCGCTGGCTACGACGACTTCAACTGCAATGTCTGGGACTCCATGAAGTCTGAGCGTGTGGCAGGGGAACAGGAACCTGATAAAGAATCA GGAGCCTCAGTGGATGAAGTAGCAAGACAGTTGGAAAGATCAGCATTGGAAGATAAAGAAAGAGATGAAGATGATGAAGATGGAGATGGC GATGGAGATGGAGCAACTGGAAAGAAGAAGAAAAAGAAGAAGAAGAAGAGAGGACCAAAAGTTCAAACAGACCCTCCCTCAGTTCCAATA TGTGACCTGTATCCTAATGGTGTATTTCCCAAAGGACAAGAATGCGAATACCCACCCACACAAGATGGGCGAACAGCTGCTTGGAGAACT ACAAGTGAAGAAAAGAAAGCATTAGATCAGGCAAGTGAAGAGATTTGGAATGATTTTCGAGAAGCTGCAGAAGCACATCGACAAGTTAGA AAATACGTAATGAGCTGGATCAAGCCTGGGATGACAATGATAGAAATCTGTGAAAAGTTGGAAGACTGTTCACGCAAGTTAATAAAAGAG AATGGATTAAATGCAGGCCTGGCATTTCCTACTGGATGTTCTCTCAATAATTGTGCTGCCCATTATACTCCCAATGCCGGTGACACAACA GTATTACAGTATGATGACATCTGTAAAATAGACTTTGGAACACATATAAGTGGTAGGATTATTGACTGTGCTTTTACTGTCACTTTTAAT CCCAAATATGATACGTTATTAAAAGCTGTAAAAGATGCTACTAACACTGGAATAAAGTGTGCTGGAATTGATGTTCGTCTGTGTGATGTT GGTGAGGCCATCCAAGAAGTTATGGAGTCCTATGAAGTTGAAATAGATGGGAAGACATATCAAGTGAAACCAATCCGTAATCTAAATGGA CATTCAATTGGGCAATATAGAATACATGCTGGAAAAACAGTGCCGATTGTGAAAGGAGGGGAGGCAACAAGAATGGAGGAAGGAGAAGTA TATGCAATTGAAACCTTTGGTAGTACAGGAAAAGGTGTTGTTCATGATGATATGGAATGTTCACATTACATGAAAAATTTTGATGTTGGA CATGTGCCAATAAGGCTTCCAAGAACAAAACACTTGTTAAATGTCATCAATGAAAACTTTGGAACCCTTGCCTTCTGCCGCAGATGGCTG GATCGCTTGGGAGAAAGTAAATACTTGATGGCTCTGAAGAATCTGTGTGACTTGGGCATTGTAGATCCATATCCACCATTATGTGACATT AAAGGATCATATACAGCGCAATTTGAACATACCATCCTGTTGCGTCCAACATGTAAAGAAGTTGTCAGCAGAGGAGATGACTATTAAACT TAGTCCAAAGCCACCTCAACACCTTTATTTTCTGAGCTTTGTTGGAAAACATGATACCAGAATTAATTTGCCACATGTTGTCTGTTTTAA CAGTGGACCCATGTAATACTTTTATCCATGTTTAAAAAAGAAGGAATTTGGACAAAGGCAAACCGTCTAATGTAATTAACCAACGAAAAA GCTTTCCGGACTTTTAAATGCTAACTGTTTTTCCCCTTCCTGTCTAGGAAAATGCTATAAAGCTCAAATTAGTTAGGAATGACTTATACG TTTTGTTTTGAATACCTAAGAGATACTTTTTGGATATTTATATTGCCATATTCTTACTTGAATGCTTTGAATGACTACATCCAGTTCTGC ACCTATACCCTCTGGTGTTGCTTTTTAACCTTCCTGGAATCCATTTTCTAAAAAATAAAGACATTTTCAGATCTGAGAGCTACATCTCAA TGTCTGTGGTTATAATTCTGGACAGGATAAATAGCTAAACTTAATGTAGGCAAATGCAGAGACATTTATCTGAAATGTAGACCTCTACAC TGAGACTTTTCTGGCATAGTGGCTAAAACAAGATCTACACATGCATAAAAAGGGACAATCACCTTTTCTTCATAAATATACAGCTTTAGG AATATTTCACCATTCTTTGTAGGACATAGTAGTCCTTGTCTTTTTTTCTCCTGACATTGGAAAGATGTGCTAATTGAAACTTGACTTAGT AGGAACATTGTGCCAACTCAAAACCTTGATTTAGTAAAAATCTCAATGTTTAGATCCTTTGTCCAGTGGTGGTGTTTATCAGGGAATGTA TTCAGCTTGCTCAGAAAACCAAAAGGGTATTAAAGCCACAAAAGCAAAGAAGAAAAAAAAAAACTTCCCATGTTTGGATCTTGTTCTAGT TAGAAAAATTAAGTTGAAATTCTTGGACTTTTTCATTCATGAGGCAAATGCTGTAATACCTTCCCCTTTGACAGGTTTGGATTCTTAACA TTACTAGTGGTATTTCAGGAAGTGACGTTACAGTTACTTTCCTTATAGCGGCTAAGTGTATTAAGTTGAATGTAACGATGGTAATATTAA TTTGTTTGAACTGAGGCCCACTACTGATTCTTTGACAAATTGAATTCTTATATTTAAATAATTTTATGGGAATGTTCCATCATAATTTCT AAATCATTTATATATCAAGGTAGCCTTAATTTGTATATGTTTCAGTACAATGAGATTTTATTGCCTCTGGGATGCTGTTTAGTTTGTATT TTGTTGAACGTTTTTATCCTAGGAAGAGAAACCTATGACTTGTGTACCTAGATCATCTGTTACATTAAAAAGCTGCTCTTTCAGCATTAG AGCTATAAATGAATGTTACCTTGTCGGGAAACAATCTAGGTTTTAGCTGTATGAGCTATGTTTATTATGGTGCTAATGTTCAGTAGCCAC ATTTGACTAATGTCTCCATTCTCTGTGATGCTGTGGCTAGCAGCAGAGCTCGCCAGTTCATGCCTGGACATACTGTCAGGGCTGGGCCCT CCAGCTAGCTCCTTTGGGGTTGAGTCCGTATCTTTTTGATGTGGAAGTATAAAGCAAGTATCTTGATTTCTAAACCCAGCAATTTTAGAA TTGACCTTTATGAGTGAAGACTTTTGGAGCTTTTAAAGACCTTGGCAGTCATGATCTCAAACCAATTAGGAGCTCCAAGCTCCCTTCCCA GGTAACTGTTGGGAGCAATGGCATCACTGTATGCCCTTGTAATGGCTGGAAGGGACATGATCTTGTAAGTAGGAAAGCTGTAACTAAAAA TTGTATTGTTTGCTTATTAGCCATGTATCTCTTAAAATTTTGTTATGTTTACAACGATGTACCTTATTGGCAACAAGTTATTAGTTTGAT >33712_33712_2_GNB3-METAP2_GNB3_chr12_6954966_ENST00000229264_METAP2_chr12_95869847_ENST00000323666_length(amino acids)=736AA_BP=308 MSAMGEMEQLRQEAEQLKKQIADARKACADVTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTT NKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQK TVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHE SIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKK KKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMT MIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKD ATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKG VVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTI -------------------------------------------------------------- >33712_33712_3_GNB3-METAP2_GNB3_chr12_6954966_ENST00000229264_METAP2_chr12_95869847_ENST00000546753_length(transcript)=2933nt_BP=1321nt CCACAATAGGGGCAGACCTGTCCATCCTTCTCTGTGGGTCCCCTGTACCTTTCTCCCCCAACAGGATCAGACCCAGAGGCAGCTGGTTGG GGTTTGTCGAGAAGAAGGATTATCCAGATCAGTCCTTTCTAATCTCAGCTCCTGCCTGTACCCTCCCATACTCACCAAACCCTCTTCCCC ACCACCCTGAGCTGAGGAGCACAGTTTGAGGCCCCCCCAACCCCCCGCCGGTCGGGGCCAGGCCAGGCCAGGCCAGCTCCTCTGGCAGCA GAGCCTGGGCAGGTGACGGGCGGGCGCGGGCGTCGCAGCTGAGGGAGTAAGGAGGCTCCCAGGAACCGGAGCTGGAAACCCGGCCGAGGT CCAGCCAGAGCCCAAGAGCCAGAGTGACCCCTCGACCTGTCAGCCATGGGGGAGATGGAGCAACTGCGTCAGGAAGCGGAGCAGCTCAAG AAGCAGATTGCAGATGCCAGGAAAGCCTGTGCTGACGTTACTCTGGCAGAGCTGGTGTCTGGCCTAGAGGTGGTGGGACGAGTCCAGATG CGGACGCGGCGGACGTTAAGGGGACACCTGGCCAAGATTTACGCCATGCACTGGGCCACTGATTCTAAGCTGCTGGTAAGTGCCTCGCAA GATGGGAAGCTGATCGTGTGGGACAGCTACACCACCAACAAGGTGCACGCCATCCCACTGCGCTCCTCCTGGGTCATGACCTGTGCCTAT GCCCCATCAGGGAACTTTGTGGCATGTGGGGGGCTGGACAACATGTGTTCCATCTACAACCTCAAATCCCGTGAGGGCAATGTCAAGGTC AGCCGGGAGCTTTCTGCTCACACAGGTTATCTCTCCTGCTGCCGCTTCCTGGATGACAACAATATTGTGACCAGCTCGGGGGACACCACG TGTGCCTTGTGGGACATTGAGACTGGGCAGCAGAAGACTGTATTTGTGGGACACACGGGTGACTGCATGAGCCTGGCTGTGTCTCCTGAC TTCAATCTCTTCATTTCGGGGGCCTGTGATGCCAGTGCCAAGCTCTGGGATGTGCGAGAGGGGACCTGCCGTCAGACTTTCACTGGCCAC GAGTCGGACATCAACGCCATCTGTTTCTTCCCCAATGGAGAGGCCATCTGCACGGGCTCGGATGACGCTTCCTGCCGCTTGTTTGACCTG CGGGCAGACCAGGAGCTGATCTGCTTCTCCCACGAGAGCATCATCTGCGGCATCACGTCCGTGGCCTTCTCCCTCAGTGGCCGCCTACTA TTCGCTGGCTACGACGACTTCAACTGCAATGTCTGGGACTCCATGAAGTCTGAGCGTGTGGCAGGGGAACAGGAACCTGATAAAGAATCA GGAGCCTCAGTGGATGAAGTAGCAAGACAGTTGGAAAGATCAGCATTGGAAGATAAAGAAAGAGATGAAGATGATGAAGATGGAGATGGC GATGGAGATGGAGCAACTGGAAAGAAGAAGAAAAAGAAGAAGAAGAAGAGAGGACGACAAGAATGCGAATACCCACCCACACAAGATGGG CGAACAGCTGCTTGGAGAACTACAAGTGAAGAAAAGAAAGCATTAGATCAGGCAAGTGAAGAGATTTGGAATGATTTTCGAGAAGCTGCA GAAGCACATCGACAAGTTAGAAAATACGTAATGAGCTGGATCAAGCCTGGGATGACAATGATAGAAATCTGTGAAAAGTTGGAAGACTGT TCACGCAAGTTAATAAAAGAGAATGGATTAAATGCAGGCCTGGCATTTCCTACTGGATGTTCTCTCAATAATTGTGCTGCCCATTATACT CCCAATGCCGGTGACACAACAGTATTACAGTATGATGACATCTGTAAAATAGACTTTGGAACACATATAAGTGGTAGGATTATTGACTGT GCTTTTACTGTCACTTTTAATCCCAAATATGATACGTTATTAAAAGCTGTAAAAGATGCTACTAACACTGGAATAAAGTGTGCTGGAATT GATGTTCGTCTGTGTGATGTTGGTGAGGCCATCCAAGAAGTTATGGAGTCCTATGAAGTTGAAATAGATGGGAAGACATATCAAGTGAAA CCAATCCGTAATCTAAATGGACATTCAATTGGGCAATATAGAATACATGCTGGAAAAACAGTGCCGATTGTGAAAGGAGGGGAGGCAACA AGAATGGAGGAAGGAGAAGTATATGCAATTGAAACCTTTGGTAGTACAGGAAAAGGTGTTGTTCATGATGATATGGAATGTTCACATTAC ATGAAAAATTTTGATGTTGGACATGTGCCAATAAGGCTTCCAAGAACAAAACACTTGTTAAATGTCATCAATGAAAACTTTGGAACCCTT GCCTTCTGCCGCAGATGGCTGGATCGCTTGGGAGAAAGTAAATACTTGATGGCTCTGAAGAATCTGTGTGACTTGGGCATTGTAGATCCA TATCCACCATTATGTGACATTAAAGGATCATATACAGCGCAATTTGAACATACCATCCTGTTGCGTCCAACATGTAAAGAAGTTGTCAGC AGAGGAGATGACTATTAAACTTAGTCCAAAGCCACCTCAACACCTTTATTTTCTGAGCTTTGTTGGAAAACATGATACCAGAATTAATTT GCCACATGTTGTCTGTTTTAACAGTGGACCCATGTAATACTTTTATCCATGTTTAAAAAAGAAGGAATTTGGACAAAGGCAAACCGTCTA ATGTAATTAACCAACGAAAAAGCTTTCCGGACTTTTAAATGCTAACTGTTTTTCCCCTTCCTGTCTAGGAAAATGCTATAAAGCTCAAAT TAGTTAGGAATGACTTATACGTTTTGTTTTGAATACCTAAGAGATACTTTTTGGATATTTATATTGCCATATTCTTACTTGAATGCTTTG >33712_33712_3_GNB3-METAP2_GNB3_chr12_6954966_ENST00000229264_METAP2_chr12_95869847_ENST00000546753_length(amino acids)=713AA_BP=308 MSAMGEMEQLRQEAEQLKKQIADARKACADVTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTT NKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQK TVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHE SIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKK KKKKRGRQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNA GLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQ EVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIR -------------------------------------------------------------- >33712_33712_4_GNB3-METAP2_GNB3_chr12_6954966_ENST00000435982_METAP2_chr12_95869847_ENST00000261220_length(transcript)=2658nt_BP=1003nt AGTAAGGAGGCTCCCAGGAACCGGAGCTGGAAACCCGGCCGAGGTCCAGCCAGAGCCCAAGAGCCAGAGTGACCCCTCGACCTGTCAGCC ATGGGGGAGATGGAGCAACTGCGTCAGGAAGCGGAGCAGCTCAAGAAGCAGATTGCAGATGCCAGGAAAGCCTGTGCTGACGTTACTCTG GCAGAGCTGGTGTCTGGCCTAGAGGTGGTGGGACGAGTCCAGATGCGGACGCGGCGGACGTTAAGGGGACACCTGGCCAAGATTTACGCC ATGCACTGGGCCACTGATTCTAAGCTGCTGGTAAGTGCCTCGCAAGATGGGAAGCTGATCGTGTGGGACAGCTACACCACCAACAAGGTG CACGCCATCCCACTGCGCTCCTCCTGGGTCATGACCTGTGCCTATGCCCCATCAGGGAACTTTGTGGCATGTGGGGGGCTGGACAACATG TGTTCCATCTACAACCTCAAATCCCGTGAGGGCAATGTCAAGGTCAGCCGGGAGCTTTCTGCTCACACAGGTTATCTCTCCTGCTGCCGC TTCCTGGATGACAACAATATTGTGACCAGCTCGGGGGACACCACTGCCTTGTGGGACATTGAGACTGGGCAGCAGAAGACTGTATTTGTG GGACACACGGGTGACTGCATGAGCCTGGCTGTGTCTCCTGACTTCAATCTCTTCATTTCGGGGGCCTGTGATGCCAGTGCCAAGCTCTGG GATGTGCGAGAGGGGACCTGCCGTCAGACTTTCACTGGCCACGAGTCGGACATCAACGCCATCTGTTTCTTCCCCAATGGAGAGGCCATC TGCACGGGCTCGGATGACGCTTCCTGCCGCTTGTTTGACCTGCGGGCAGACCAGGAGCTGATCTGCTTCTCCCACGAGAGCATCATCTGC GGCATCACGTCCGTGGCCTTCTCCCTCAGTGGCCGCCTACTATTCGCTGGCTACGACGACTTCAACTGCAATGTCTGGGACTCCATGAAG TCTGAGCGTGTGGGGGAACAGGAACCTGATAAAGAATCAGGAGCCTCAGTGGATGAAGTAGCAAGACAGTTGGAAAGATCAGCATTGGAA GATAAAGAAAGAGATGAAGATGATGAAGCAAAAGTTCAAACAGACCCTCCCTCAGTTCCAATATGTGACCTGTATCCTAATGGTGTATTT CCCAAAGGACAAGAATGCGAATACCCACCCACACAAGATGGGCGAACAGCTGCTTGGAGAACTACAAGTGAAGAAAAGAAAGCATTAGAT CAGGCAAGTGAAGAGATTTGGAATGATTTTCGAGAAGCTGCAGAAGCACATCGACAAGTTAGAAAATACGTAATGAGCTGGATCAAGCCT GGGATGACAATGATAGAAATCTGTGAAAAGTTGGAAGACTGTTCACGCAAGTTAATAAAAGAGAATGGATTAAATGCAGGCCTGGCATTT CCTACTGGATGTTCTCTCAATAATTGTGCTGCCCATTATACTCCCAATGCCGGTGACACAACAGTATTACAGTATGATGACATCTGTAAA ATAGACTTTGGAACACATATAAGTGGTAGGATTATTGACTGTGCTTTTACTGTCACTTTTAATCCCAAATATGATACGTTATTAAAAGCT GTAAAAGATGCTACTAACACTGGAATAAAGTGTGCTGGAATTGATGTTCGTCTGTGTGATGTTGGTGAGGCCATCCAAGAAGTTATGGAG TCCTATGAAGTTGAAATAGATGGGAAGACATATCAAGTGAAACCAATCCGTAATCTAAATGGACATTCAATTGGGCAATATAGAATACAT GCTGGAAAAACAGTGCCGATTGTGAAAGGAGGGGAGGCAACAAGAATGGAGGAAGGAGAAGTATATGCAATTGAAACCTTTGGTAGTACA GGAAAAGGTGTTGTTCATGATGATATGGAATGTTCACATTACATGAAAAATTTTGATGTTGGACATGTGCCAATAAGGCTTCCAAGAACA AAACACTTGTTAAATGTCATCAATGAAAACTTTGGAACCCTTGCCTTCTGCCGCAGATGGCTGGATCGCTTGGGAGAAAGTAAATACTTG ATGGCTCTGAAGAATCTGTGTGACTTGGGCATTGTAGATCCATATCCACCATTATGTGACATTAAAGGATCATATACAGCGCAATTTGAA CATACCATCCTGTTGCGTCCAACATGTAAAGAAGTTGTCAGCAGAGGAGATGACTATTAAACTTAGTCCAAAGCCACCTCAACACCTTTA TTTTCTGAGCTTTGTTGGAAAACATGATACCAGAATTAATTTGCCACATGTTGTCTGTTTTAACAGTGGACCCATGTAATACTTTTATCC ATGTTTAAAAAAGAAGGAATTTGGACAAAGGCAAACCGTCTAATGTAATTAACCAACGAAAAAGCTTTCCGGACTTTTAAATGCTAACTG TTTTTCCCCTTCCTGTCTAGGAAAATGCTATAAAGCTCAAATTAGTTAGGAATGACTTATACGTTTTGTTTTGAATACCTAAGAGATACT TTTTGGATATTTATATTGCCATATTCTTACTTGAATGCTTTGAATGACTACATCCAGTTCTGCACCTATACCCTCTGGTGTTGCTTTTTA >33712_33712_4_GNB3-METAP2_GNB3_chr12_6954966_ENST00000435982_METAP2_chr12_95869847_ENST00000261220_length(amino acids)=712AA_BP=307 MSAMGEMEQLRQEAEQLKKQIADARKACADVTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTT NKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTALWDIETGQQKT VFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHES IICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGEQEPDKESGASVDEVARQLERSALEDKERDEDDEAKVQTDPPSVPICDLYPN GVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAG LAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQE VMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRL -------------------------------------------------------------- >33712_33712_5_GNB3-METAP2_GNB3_chr12_6954966_ENST00000435982_METAP2_chr12_95869847_ENST00000323666_length(transcript)=4224nt_BP=1003nt AGTAAGGAGGCTCCCAGGAACCGGAGCTGGAAACCCGGCCGAGGTCCAGCCAGAGCCCAAGAGCCAGAGTGACCCCTCGACCTGTCAGCC ATGGGGGAGATGGAGCAACTGCGTCAGGAAGCGGAGCAGCTCAAGAAGCAGATTGCAGATGCCAGGAAAGCCTGTGCTGACGTTACTCTG GCAGAGCTGGTGTCTGGCCTAGAGGTGGTGGGACGAGTCCAGATGCGGACGCGGCGGACGTTAAGGGGACACCTGGCCAAGATTTACGCC ATGCACTGGGCCACTGATTCTAAGCTGCTGGTAAGTGCCTCGCAAGATGGGAAGCTGATCGTGTGGGACAGCTACACCACCAACAAGGTG CACGCCATCCCACTGCGCTCCTCCTGGGTCATGACCTGTGCCTATGCCCCATCAGGGAACTTTGTGGCATGTGGGGGGCTGGACAACATG TGTTCCATCTACAACCTCAAATCCCGTGAGGGCAATGTCAAGGTCAGCCGGGAGCTTTCTGCTCACACAGGTTATCTCTCCTGCTGCCGC TTCCTGGATGACAACAATATTGTGACCAGCTCGGGGGACACCACTGCCTTGTGGGACATTGAGACTGGGCAGCAGAAGACTGTATTTGTG GGACACACGGGTGACTGCATGAGCCTGGCTGTGTCTCCTGACTTCAATCTCTTCATTTCGGGGGCCTGTGATGCCAGTGCCAAGCTCTGG GATGTGCGAGAGGGGACCTGCCGTCAGACTTTCACTGGCCACGAGTCGGACATCAACGCCATCTGTTTCTTCCCCAATGGAGAGGCCATC TGCACGGGCTCGGATGACGCTTCCTGCCGCTTGTTTGACCTGCGGGCAGACCAGGAGCTGATCTGCTTCTCCCACGAGAGCATCATCTGC GGCATCACGTCCGTGGCCTTCTCCCTCAGTGGCCGCCTACTATTCGCTGGCTACGACGACTTCAACTGCAATGTCTGGGACTCCATGAAG TCTGAGCGTGTGGCAGGGGAACAGGAACCTGATAAAGAATCAGGAGCCTCAGTGGATGAAGTAGCAAGACAGTTGGAAAGATCAGCATTG GAAGATAAAGAAAGAGATGAAGATGATGAAGATGGAGATGGCGATGGAGATGGAGCAACTGGAAAGAAGAAGAAAAAGAAGAAGAAGAAG AGAGGACCAAAAGTTCAAACAGACCCTCCCTCAGTTCCAATATGTGACCTGTATCCTAATGGTGTATTTCCCAAAGGACAAGAATGCGAA TACCCACCCACACAAGATGGGCGAACAGCTGCTTGGAGAACTACAAGTGAAGAAAAGAAAGCATTAGATCAGGCAAGTGAAGAGATTTGG AATGATTTTCGAGAAGCTGCAGAAGCACATCGACAAGTTAGAAAATACGTAATGAGCTGGATCAAGCCTGGGATGACAATGATAGAAATC TGTGAAAAGTTGGAAGACTGTTCACGCAAGTTAATAAAAGAGAATGGATTAAATGCAGGCCTGGCATTTCCTACTGGATGTTCTCTCAAT AATTGTGCTGCCCATTATACTCCCAATGCCGGTGACACAACAGTATTACAGTATGATGACATCTGTAAAATAGACTTTGGAACACATATA AGTGGTAGGATTATTGACTGTGCTTTTACTGTCACTTTTAATCCCAAATATGATACGTTATTAAAAGCTGTAAAAGATGCTACTAACACT GGAATAAAGTGTGCTGGAATTGATGTTCGTCTGTGTGATGTTGGTGAGGCCATCCAAGAAGTTATGGAGTCCTATGAAGTTGAAATAGAT GGGAAGACATATCAAGTGAAACCAATCCGTAATCTAAATGGACATTCAATTGGGCAATATAGAATACATGCTGGAAAAACAGTGCCGATT GTGAAAGGAGGGGAGGCAACAAGAATGGAGGAAGGAGAAGTATATGCAATTGAAACCTTTGGTAGTACAGGAAAAGGTGTTGTTCATGAT GATATGGAATGTTCACATTACATGAAAAATTTTGATGTTGGACATGTGCCAATAAGGCTTCCAAGAACAAAACACTTGTTAAATGTCATC AATGAAAACTTTGGAACCCTTGCCTTCTGCCGCAGATGGCTGGATCGCTTGGGAGAAAGTAAATACTTGATGGCTCTGAAGAATCTGTGT GACTTGGGCATTGTAGATCCATATCCACCATTATGTGACATTAAAGGATCATATACAGCGCAATTTGAACATACCATCCTGTTGCGTCCA ACATGTAAAGAAGTTGTCAGCAGAGGAGATGACTATTAAACTTAGTCCAAAGCCACCTCAACACCTTTATTTTCTGAGCTTTGTTGGAAA ACATGATACCAGAATTAATTTGCCACATGTTGTCTGTTTTAACAGTGGACCCATGTAATACTTTTATCCATGTTTAAAAAAGAAGGAATT TGGACAAAGGCAAACCGTCTAATGTAATTAACCAACGAAAAAGCTTTCCGGACTTTTAAATGCTAACTGTTTTTCCCCTTCCTGTCTAGG AAAATGCTATAAAGCTCAAATTAGTTAGGAATGACTTATACGTTTTGTTTTGAATACCTAAGAGATACTTTTTGGATATTTATATTGCCA TATTCTTACTTGAATGCTTTGAATGACTACATCCAGTTCTGCACCTATACCCTCTGGTGTTGCTTTTTAACCTTCCTGGAATCCATTTTC TAAAAAATAAAGACATTTTCAGATCTGAGAGCTACATCTCAATGTCTGTGGTTATAATTCTGGACAGGATAAATAGCTAAACTTAATGTA GGCAAATGCAGAGACATTTATCTGAAATGTAGACCTCTACACTGAGACTTTTCTGGCATAGTGGCTAAAACAAGATCTACACATGCATAA AAAGGGACAATCACCTTTTCTTCATAAATATACAGCTTTAGGAATATTTCACCATTCTTTGTAGGACATAGTAGTCCTTGTCTTTTTTTC TCCTGACATTGGAAAGATGTGCTAATTGAAACTTGACTTAGTAGGAACATTGTGCCAACTCAAAACCTTGATTTAGTAAAAATCTCAATG TTTAGATCCTTTGTCCAGTGGTGGTGTTTATCAGGGAATGTATTCAGCTTGCTCAGAAAACCAAAAGGGTATTAAAGCCACAAAAGCAAA GAAGAAAAAAAAAAACTTCCCATGTTTGGATCTTGTTCTAGTTAGAAAAATTAAGTTGAAATTCTTGGACTTTTTCATTCATGAGGCAAA TGCTGTAATACCTTCCCCTTTGACAGGTTTGGATTCTTAACATTACTAGTGGTATTTCAGGAAGTGACGTTACAGTTACTTTCCTTATAG CGGCTAAGTGTATTAAGTTGAATGTAACGATGGTAATATTAATTTGTTTGAACTGAGGCCCACTACTGATTCTTTGACAAATTGAATTCT TATATTTAAATAATTTTATGGGAATGTTCCATCATAATTTCTAAATCATTTATATATCAAGGTAGCCTTAATTTGTATATGTTTCAGTAC AATGAGATTTTATTGCCTCTGGGATGCTGTTTAGTTTGTATTTTGTTGAACGTTTTTATCCTAGGAAGAGAAACCTATGACTTGTGTACC TAGATCATCTGTTACATTAAAAAGCTGCTCTTTCAGCATTAGAGCTATAAATGAATGTTACCTTGTCGGGAAACAATCTAGGTTTTAGCT GTATGAGCTATGTTTATTATGGTGCTAATGTTCAGTAGCCACATTTGACTAATGTCTCCATTCTCTGTGATGCTGTGGCTAGCAGCAGAG CTCGCCAGTTCATGCCTGGACATACTGTCAGGGCTGGGCCCTCCAGCTAGCTCCTTTGGGGTTGAGTCCGTATCTTTTTGATGTGGAAGT ATAAAGCAAGTATCTTGATTTCTAAACCCAGCAATTTTAGAATTGACCTTTATGAGTGAAGACTTTTGGAGCTTTTAAAGACCTTGGCAG TCATGATCTCAAACCAATTAGGAGCTCCAAGCTCCCTTCCCAGGTAACTGTTGGGAGCAATGGCATCACTGTATGCCCTTGTAATGGCTG GAAGGGACATGATCTTGTAAGTAGGAAAGCTGTAACTAAAAATTGTATTGTTTGCTTATTAGCCATGTATCTCTTAAAATTTTGTTATGT >33712_33712_5_GNB3-METAP2_GNB3_chr12_6954966_ENST00000435982_METAP2_chr12_95869847_ENST00000323666_length(amino acids)=735AA_BP=307 MSAMGEMEQLRQEAEQLKKQIADARKACADVTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTT NKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTALWDIETGQQKT VFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHES IICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKK KKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTM IEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDA TNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGV VHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTIL -------------------------------------------------------------- >33712_33712_6_GNB3-METAP2_GNB3_chr12_6954966_ENST00000435982_METAP2_chr12_95869847_ENST00000546753_length(transcript)=2615nt_BP=1003nt AGTAAGGAGGCTCCCAGGAACCGGAGCTGGAAACCCGGCCGAGGTCCAGCCAGAGCCCAAGAGCCAGAGTGACCCCTCGACCTGTCAGCC ATGGGGGAGATGGAGCAACTGCGTCAGGAAGCGGAGCAGCTCAAGAAGCAGATTGCAGATGCCAGGAAAGCCTGTGCTGACGTTACTCTG GCAGAGCTGGTGTCTGGCCTAGAGGTGGTGGGACGAGTCCAGATGCGGACGCGGCGGACGTTAAGGGGACACCTGGCCAAGATTTACGCC ATGCACTGGGCCACTGATTCTAAGCTGCTGGTAAGTGCCTCGCAAGATGGGAAGCTGATCGTGTGGGACAGCTACACCACCAACAAGGTG CACGCCATCCCACTGCGCTCCTCCTGGGTCATGACCTGTGCCTATGCCCCATCAGGGAACTTTGTGGCATGTGGGGGGCTGGACAACATG TGTTCCATCTACAACCTCAAATCCCGTGAGGGCAATGTCAAGGTCAGCCGGGAGCTTTCTGCTCACACAGGTTATCTCTCCTGCTGCCGC TTCCTGGATGACAACAATATTGTGACCAGCTCGGGGGACACCACTGCCTTGTGGGACATTGAGACTGGGCAGCAGAAGACTGTATTTGTG GGACACACGGGTGACTGCATGAGCCTGGCTGTGTCTCCTGACTTCAATCTCTTCATTTCGGGGGCCTGTGATGCCAGTGCCAAGCTCTGG GATGTGCGAGAGGGGACCTGCCGTCAGACTTTCACTGGCCACGAGTCGGACATCAACGCCATCTGTTTCTTCCCCAATGGAGAGGCCATC TGCACGGGCTCGGATGACGCTTCCTGCCGCTTGTTTGACCTGCGGGCAGACCAGGAGCTGATCTGCTTCTCCCACGAGAGCATCATCTGC GGCATCACGTCCGTGGCCTTCTCCCTCAGTGGCCGCCTACTATTCGCTGGCTACGACGACTTCAACTGCAATGTCTGGGACTCCATGAAG TCTGAGCGTGTGGCAGGGGAACAGGAACCTGATAAAGAATCAGGAGCCTCAGTGGATGAAGTAGCAAGACAGTTGGAAAGATCAGCATTG GAAGATAAAGAAAGAGATGAAGATGATGAAGATGGAGATGGCGATGGAGATGGAGCAACTGGAAAGAAGAAGAAAAAGAAGAAGAAGAAG AGAGGACGACAAGAATGCGAATACCCACCCACACAAGATGGGCGAACAGCTGCTTGGAGAACTACAAGTGAAGAAAAGAAAGCATTAGAT CAGGCAAGTGAAGAGATTTGGAATGATTTTCGAGAAGCTGCAGAAGCACATCGACAAGTTAGAAAATACGTAATGAGCTGGATCAAGCCT GGGATGACAATGATAGAAATCTGTGAAAAGTTGGAAGACTGTTCACGCAAGTTAATAAAAGAGAATGGATTAAATGCAGGCCTGGCATTT CCTACTGGATGTTCTCTCAATAATTGTGCTGCCCATTATACTCCCAATGCCGGTGACACAACAGTATTACAGTATGATGACATCTGTAAA ATAGACTTTGGAACACATATAAGTGGTAGGATTATTGACTGTGCTTTTACTGTCACTTTTAATCCCAAATATGATACGTTATTAAAAGCT GTAAAAGATGCTACTAACACTGGAATAAAGTGTGCTGGAATTGATGTTCGTCTGTGTGATGTTGGTGAGGCCATCCAAGAAGTTATGGAG TCCTATGAAGTTGAAATAGATGGGAAGACATATCAAGTGAAACCAATCCGTAATCTAAATGGACATTCAATTGGGCAATATAGAATACAT GCTGGAAAAACAGTGCCGATTGTGAAAGGAGGGGAGGCAACAAGAATGGAGGAAGGAGAAGTATATGCAATTGAAACCTTTGGTAGTACA GGAAAAGGTGTTGTTCATGATGATATGGAATGTTCACATTACATGAAAAATTTTGATGTTGGACATGTGCCAATAAGGCTTCCAAGAACA AAACACTTGTTAAATGTCATCAATGAAAACTTTGGAACCCTTGCCTTCTGCCGCAGATGGCTGGATCGCTTGGGAGAAAGTAAATACTTG ATGGCTCTGAAGAATCTGTGTGACTTGGGCATTGTAGATCCATATCCACCATTATGTGACATTAAAGGATCATATACAGCGCAATTTGAA CATACCATCCTGTTGCGTCCAACATGTAAAGAAGTTGTCAGCAGAGGAGATGACTATTAAACTTAGTCCAAAGCCACCTCAACACCTTTA TTTTCTGAGCTTTGTTGGAAAACATGATACCAGAATTAATTTGCCACATGTTGTCTGTTTTAACAGTGGACCCATGTAATACTTTTATCC ATGTTTAAAAAAGAAGGAATTTGGACAAAGGCAAACCGTCTAATGTAATTAACCAACGAAAAAGCTTTCCGGACTTTTAAATGCTAACTG TTTTTCCCCTTCCTGTCTAGGAAAATGCTATAAAGCTCAAATTAGTTAGGAATGACTTATACGTTTTGTTTTGAATACCTAAGAGATACT TTTTGGATATTTATATTGCCATATTCTTACTTGAATGCTTTGAATGACTACATCCAGTTCTGCACCTATACCCTCTGGTGTTGCTTTTTA >33712_33712_6_GNB3-METAP2_GNB3_chr12_6954966_ENST00000435982_METAP2_chr12_95869847_ENST00000546753_length(amino acids)=712AA_BP=307 MSAMGEMEQLRQEAEQLKKQIADARKACADVTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTT NKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTALWDIETGQQKT VFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHES IICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKK KKKRGRQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAG LAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQE VMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRL -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for GNB3-METAP2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for GNB3-METAP2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for GNB3-METAP2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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