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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GNE-LOH12CR1 (FusionGDB2 ID:33727)

Fusion Gene Summary for GNE-LOH12CR1

check button Fusion gene summary
Fusion gene informationFusion gene name: GNE-LOH12CR1
Fusion gene ID: 33727
HgeneTgene
Gene symbol

GNE

LOH12CR1

Gene ID

10020

118426

Gene nameglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinaseBLOC-1 related complex subunit 5
SynonymsDMRV|GLCNE|IBM2|NM|Uae1LOH12CR1|LOH1CR12
Cytomap

9p13.3

12p13.2

Type of geneprotein-codingprotein-coding
Descriptionbifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinaseN-acylmannosamine kinaseUDP-GlcNAc-2-epimerase/ManAc kinaseUDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinaseBLOC-1-related complex subunit 5loss of heterozygosity 12 chromosomal region 1 proteinloss of heterozygosity, 12, chromosomal region 1myristoylated lysosomal proteinmyrlysin
Modification date2020032820200313
UniProtAcc

Q9Y223

.
Ensembl transtripts involved in fusion geneENST00000377902, ENST00000447283, 
ENST00000396594, ENST00000539208, 
ENST00000539815, ENST00000543356, 
ENST00000298571, ENST00000314565, 
ENST00000542728, 
Fusion gene scores* DoF score7 X 9 X 6=3787 X 3 X 6=126
# samples 108
** MAII scorelog2(10/378*10)=-1.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/126*10)=-0.655351828612554
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GNE [Title/Abstract] AND LOH12CR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGNE(36218179)-LOH12CR1(12588561), # samples:1
Anticipated loss of major functional domain due to fusion event.GNE-LOH12CR1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across GNE (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LOH12CR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-R6-A6Y0GNEchr9

36218179

-LOH12CR1chr12

12588561

+


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Fusion Gene ORF analysis for GNE-LOH12CR1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000377902ENST00000298571GNEchr9

36218179

-LOH12CR1chr12

12588561

+
Frame-shiftENST00000377902ENST00000314565GNEchr9

36218179

-LOH12CR1chr12

12588561

+
Frame-shiftENST00000377902ENST00000542728GNEchr9

36218179

-LOH12CR1chr12

12588561

+
Frame-shiftENST00000447283ENST00000298571GNEchr9

36218179

-LOH12CR1chr12

12588561

+
Frame-shiftENST00000447283ENST00000314565GNEchr9

36218179

-LOH12CR1chr12

12588561

+
Frame-shiftENST00000447283ENST00000542728GNEchr9

36218179

-LOH12CR1chr12

12588561

+
In-frameENST00000396594ENST00000298571GNEchr9

36218179

-LOH12CR1chr12

12588561

+
In-frameENST00000396594ENST00000314565GNEchr9

36218179

-LOH12CR1chr12

12588561

+
In-frameENST00000396594ENST00000542728GNEchr9

36218179

-LOH12CR1chr12

12588561

+
In-frameENST00000539208ENST00000298571GNEchr9

36218179

-LOH12CR1chr12

12588561

+
In-frameENST00000539208ENST00000314565GNEchr9

36218179

-LOH12CR1chr12

12588561

+
In-frameENST00000539208ENST00000542728GNEchr9

36218179

-LOH12CR1chr12

12588561

+
In-frameENST00000539815ENST00000298571GNEchr9

36218179

-LOH12CR1chr12

12588561

+
In-frameENST00000539815ENST00000314565GNEchr9

36218179

-LOH12CR1chr12

12588561

+
In-frameENST00000539815ENST00000542728GNEchr9

36218179

-LOH12CR1chr12

12588561

+
In-frameENST00000543356ENST00000298571GNEchr9

36218179

-LOH12CR1chr12

12588561

+
In-frameENST00000543356ENST00000314565GNEchr9

36218179

-LOH12CR1chr12

12588561

+
In-frameENST00000543356ENST00000542728GNEchr9

36218179

-LOH12CR1chr12

12588561

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000396594GNEchr936218179-ENST00000542728LOH12CR1chr1212588561+25342138642526820
ENST00000396594GNEchr936218179-ENST00000314565LOH12CR1chr1212588561+36572138642526820
ENST00000396594GNEchr936218179-ENST00000298571LOH12CR1chr1212588561+25952138642526820
ENST00000539815GNEchr936218179-ENST00000542728LOH12CR1chr1212588561+23701974412362773
ENST00000539815GNEchr936218179-ENST00000314565LOH12CR1chr1212588561+34931974412362773
ENST00000539815GNEchr936218179-ENST00000298571LOH12CR1chr1212588561+24311974412362773
ENST00000543356GNEchr936218179-ENST00000542728LOH12CR1chr1212588561+2314191802306768
ENST00000543356GNEchr936218179-ENST00000314565LOH12CR1chr1212588561+3437191802306768
ENST00000543356GNEchr936218179-ENST00000298571LOH12CR1chr1212588561+2375191802306768
ENST00000539208GNEchr936218179-ENST00000542728LOH12CR1chr1212588561+213717411382129663
ENST00000539208GNEchr936218179-ENST00000314565LOH12CR1chr1212588561+326017411382129663
ENST00000539208GNEchr936218179-ENST00000298571LOH12CR1chr1212588561+219817411382129663

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000396594ENST00000542728GNEchr936218179-LOH12CR1chr1212588561+0.0020575770.9979424
ENST00000396594ENST00000314565GNEchr936218179-LOH12CR1chr1212588561+0.0009904260.9990095
ENST00000396594ENST00000298571GNEchr936218179-LOH12CR1chr1212588561+0.0021163970.9978836
ENST00000539815ENST00000542728GNEchr936218179-LOH12CR1chr1212588561+0.0038443840.9961557
ENST00000539815ENST00000314565GNEchr936218179-LOH12CR1chr1212588561+0.0021905780.99780947
ENST00000539815ENST00000298571GNEchr936218179-LOH12CR1chr1212588561+0.0039972870.99600273
ENST00000543356ENST00000542728GNEchr936218179-LOH12CR1chr1212588561+0.0046706640.9953294
ENST00000543356ENST00000314565GNEchr936218179-LOH12CR1chr1212588561+0.0029266250.9970734
ENST00000543356ENST00000298571GNEchr936218179-LOH12CR1chr1212588561+0.0049795780.9950204
ENST00000539208ENST00000542728GNEchr936218179-LOH12CR1chr1212588561+0.0041491960.9958508
ENST00000539208ENST00000314565GNEchr936218179-LOH12CR1chr1212588561+0.0021226290.99787736
ENST00000539208ENST00000298571GNEchr936218179-LOH12CR1chr1212588561+0.0047191350.9952808

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Fusion Genomic Features for GNE-LOH12CR1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GNEchr936218179-LOH12CR1chr1212588561+1.39E-081
GNEchr936218179-LOH12CR1chr1212588561+1.39E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GNE-LOH12CR1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:36218179/chr12:12588561)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GNE

Q9Y223

.
FUNCTION: Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. {ECO:0000250, ECO:0000269|PubMed:10334995}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGNEchr9:36218179chr12:12588561ENST00000377902-1112411_420644723.0Nucleotide bindingNote=ATP
HgeneGNEchr9:36218179chr12:12588561ENST00000377902-1112543_552644723.0Nucleotide bindingNote=ATP
HgeneGNEchr9:36218179chr12:12588561ENST00000396594-1112411_420675754.0Nucleotide bindingNote=ATP
HgeneGNEchr9:36218179chr12:12588561ENST00000396594-1112543_552675754.0Nucleotide bindingNote=ATP
HgeneGNEchr9:36218179chr12:12588561ENST00000447283-1011411_420570649.0Nucleotide bindingNote=ATP
HgeneGNEchr9:36218179chr12:12588561ENST00000447283-1011543_552570649.0Nucleotide bindingNote=ATP
HgeneGNEchr9:36218179chr12:12588561ENST00000539208-910411_420534613.0Nucleotide bindingNote=ATP
HgeneGNEchr9:36218179chr12:12588561ENST00000539815-1012411_4206441065.0Nucleotide bindingNote=ATP
HgeneGNEchr9:36218179chr12:12588561ENST00000539815-1012543_5526441065.0Nucleotide bindingNote=ATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGNEchr9:36218179chr12:12588561ENST00000539208-910543_552534613.0Nucleotide bindingNote=ATP
HgeneGNEchr9:36218179chr12:12588561ENST00000377902-1112406_722644723.0RegionNote=N-acetylmannosamine kinase
HgeneGNEchr9:36218179chr12:12588561ENST00000396594-1112406_722675754.0RegionNote=N-acetylmannosamine kinase
HgeneGNEchr9:36218179chr12:12588561ENST00000447283-1011406_722570649.0RegionNote=N-acetylmannosamine kinase
HgeneGNEchr9:36218179chr12:12588561ENST00000539208-910406_722534613.0RegionNote=N-acetylmannosamine kinase
HgeneGNEchr9:36218179chr12:12588561ENST00000539815-1012406_7226441065.0RegionNote=N-acetylmannosamine kinase


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Fusion Gene Sequence for GNE-LOH12CR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>33727_33727_1_GNE-LOH12CR1_GNE_chr9_36218179_ENST00000396594_LOH12CR1_chr12_12588561_ENST00000298571_length(transcript)=2595nt_BP=2138nt
AGTCTGGAATTCAGATGCCTATTGGTGACTGCTCCGTGGCAGCTAAACCAAGAAAACAGCTGCTCTGCTCATTATTTCAAACCACACTAG
GGTACAGAGCTCGTGCTTCGGGATGGAAACCTATGGTTATCTGCAGAGGGAGTCATGCTTTCAAGGACCTCATGAACTCTATTTTAAGAA
CCTCTCAAAACGAAACAAGCAAATCATGGAGAAGAATGGAAATAACCGAAAGCTGCGGGTTTGTGTTGCTACTTGTAACCGTGCAGATTA
TTCTAAACTTGCCCCGATCATGTTTGGCATTAAAACCGAACCTGAGTTCTTTGAACTTGATGTTGTGGTACTTGGCTCTCACCTGATAGA
TGACTATGGAAATACATATCGAATGATTGAACAAGATGACTTTGACATTAACACCAGGCTACACACAATTGTGAGGGGAGAAGATGAGGC
AGCCATGGTGGAGTCAGTAGGCCTGGCCCTAGTGAAGCTGCCAGATGTCCTTAATCGCCTGAAGCCTGATATCATGATTGTTCATGGAGA
CAGGTTTGATGCCCTGGCTCTGGCCACATCTGCTGCCTTGATGAACATCCGAATCCTTCACATTGAAGGTGGGGAAGTCAGTGGGACCAT
TGATGACTCTATCAGACATGCCATAACAAAACTGGCTCATTATCATGTGTGCTGCACCCGCAGTGCAGAGCAGCACCTGATATCCATGTG
TGAGGACCATGATCGCATCCTTTTGGCAGGCTGCCCTTCCTATGACAAACTTCTCTCAGCCAAGAACAAAGACTACATGAGCATCATTCG
CATGTGGCTAGGTGATGATGTAAAATCTAAAGATTACATTGTTGCACTACAGCACCCTGTGACCACTGACATTAAGCATTCCATAAAAAT
GTTTGAATTAACATTGGATGCACTTATCTCATTTAACAAGCGGACCCTAGTCCTGTTTCCAAATATTGACGCAGGGAGCAAAGAGATGGT
TCGAGTGATGCGGAAGAAGGGCATTGAGCATCATCCCAACTTTCGTGCAGTTAAACACGTCCCATTTGACCAGTTTATACAGTTGGTTGC
CCATGCTGGCTGTATGATTGGGAACAGCAGCTGTGGGGTTCGAGAAGTTGGAGCTTTTGGAACACCTGTGATCAACCTGGGAACACGTCA
GATTGGAAGAGAAACAGGGGAGAATGTTCTTCATGTCCGGGATGCTGACACCCAAGACAAAATATTGCAAGCACTGCACCTTCAGTTTGG
TAAACAGTACCCTTGTTCAAAGATATATGGGGATGGAAATGCTGTTCCAAGGATTTTGAAGTTTCTCAAATCTATCGATCTTCAAGAGCC
ACTGCAAAAGAAATTCTGCTTTCCTCCTGTGAAGGAGAATATCTCTCAAGATATTGACCATATTCTTGAAACTCTAAGTGCCTTGGCCGT
TGATCTTGGCGGGACGAACCTCCGAGTTGCAATAGTCAGCATGAAGGGTGAAATAGTTAAGAAGTATACTCAGTTCAATCCTAAAACCTA
TGAAGAGAGGATTAATTTAATCCTACAGATGTGTGTGGAAGCTGCAGCAGAAGCTGTAAAACTGAACTGCAGAATTTTGGGAGTAGGCAT
TTCCACAGGTGGCCGTGTAAATCCTCGGGAAGGAATTGTGCTGCATTCAACCAAACTGATCCAAGAGTGGAACTCTGTGGACCTTAGGAC
CCCCCTTTCTGACACTTTGCATCTCCCTGTGTGGGTAGACAATGATGGCAACTGTGCTGCCCTGGCGGAAAGGAAATTTGGCCAAGGAAA
GGGACTGGAAAACTTTGTTACACTTATCACAGGCACAGGAATCGGTGGTGGAATTATCCATCAGCATGAATTGATCCACGGAAGCTCCTT
CTGTGCTGCAGAACTGGGCCACCTTGTTGTGTCTCTGGATGGGCCTGATTGTTCCTGTGGAAGCCATGGGTGCATTGAAGCATACGCCTC
TGGAATGGCCTTGCAGAGGGAGGCAAAAAAGCTCCATGATGAGGACCTGCTCTTGGTGGAAGGGATGTCAGTGCCAAAAGATGAGGCTGT
GGGTGCGCTCCATCTCATCCAAGCTGCGAAACTTGGCAATGCGAAGGCCCAGAGCATCCTAAGAACAGGGCTATTGAGTGGCCAGACTTC
CCCAACAAATGCCAAATTGGAGAAACTGGACTCTCAGCAGGTGTTGCAGCTCTGCCTCCGATATCAAGATCACCTGCATCAGTGTGCAGA
GGCCGTTGCTTTTGACCAGAATGCTTTGGTTAAACGAATCAAAGAGATGGATCTGTCTGTAGAAACTCTGTTCAGCTTCATGCAGGAGCG
CCAGAAAAGATACGCCAAGTATGCCGAGCAGATCCAGAAAGTGAACGAGATGTCCGCCATCCTCCGCCGCATACAGATGGGCATCGACCA
GACTGTGCCCCTGCTGGACAGGCTCAACAGCATGCTGCCCGAGGGCGAGCGGCTGGAGCCCTTCAGCATGAAGCCCGACCGCGAGCTCAG

>33727_33727_1_GNE-LOH12CR1_GNE_chr9_36218179_ENST00000396594_LOH12CR1_chr12_12588561_ENST00000298571_length(amino acids)=820AA_BP=691
MLIISNHTRVQSSCFGMETYGYLQRESCFQGPHELYFKNLSKRNKQIMEKNGNNRKLRVCVATCNRADYSKLAPIMFGIKTEPEFFELDV
VVLGSHLIDDYGNTYRMIEQDDFDINTRLHTIVRGEDEAAMVESVGLALVKLPDVLNRLKPDIMIVHGDRFDALALATSAALMNIRILHI
EGGEVSGTIDDSIRHAITKLAHYHVCCTRSAEQHLISMCEDHDRILLAGCPSYDKLLSAKNKDYMSIIRMWLGDDVKSKDYIVALQHPVT
TDIKHSIKMFELTLDALISFNKRTLVLFPNIDAGSKEMVRVMRKKGIEHHPNFRAVKHVPFDQFIQLVAHAGCMIGNSSCGVREVGAFGT
PVINLGTRQIGRETGENVLHVRDADTQDKILQALHLQFGKQYPCSKIYGDGNAVPRILKFLKSIDLQEPLQKKFCFPPVKENISQDIDHI
LETLSALAVDLGGTNLRVAIVSMKGEIVKKYTQFNPKTYEERINLILQMCVEAAAEAVKLNCRILGVGISTGGRVNPREGIVLHSTKLIQ
EWNSVDLRTPLSDTLHLPVWVDNDGNCAALAERKFGQGKGLENFVTLITGTGIGGGIIHQHELIHGSSFCAAELGHLVVSLDGPDCSCGS
HGCIEAYASGMALQREAKKLHDEDLLLVEGMSVPKDEAVGALHLIQAAKLGNAKAQSILRTGLLSGQTSPTNAKLEKLDSQQVLQLCLRY
QDHLHQCAEAVAFDQNALVKRIKEMDLSVETLFSFMQERQKRYAKYAEQIQKVNEMSAILRRIQMGIDQTVPLLDRLNSMLPEGERLEPF

--------------------------------------------------------------
>33727_33727_2_GNE-LOH12CR1_GNE_chr9_36218179_ENST00000396594_LOH12CR1_chr12_12588561_ENST00000314565_length(transcript)=3657nt_BP=2138nt
AGTCTGGAATTCAGATGCCTATTGGTGACTGCTCCGTGGCAGCTAAACCAAGAAAACAGCTGCTCTGCTCATTATTTCAAACCACACTAG
GGTACAGAGCTCGTGCTTCGGGATGGAAACCTATGGTTATCTGCAGAGGGAGTCATGCTTTCAAGGACCTCATGAACTCTATTTTAAGAA
CCTCTCAAAACGAAACAAGCAAATCATGGAGAAGAATGGAAATAACCGAAAGCTGCGGGTTTGTGTTGCTACTTGTAACCGTGCAGATTA
TTCTAAACTTGCCCCGATCATGTTTGGCATTAAAACCGAACCTGAGTTCTTTGAACTTGATGTTGTGGTACTTGGCTCTCACCTGATAGA
TGACTATGGAAATACATATCGAATGATTGAACAAGATGACTTTGACATTAACACCAGGCTACACACAATTGTGAGGGGAGAAGATGAGGC
AGCCATGGTGGAGTCAGTAGGCCTGGCCCTAGTGAAGCTGCCAGATGTCCTTAATCGCCTGAAGCCTGATATCATGATTGTTCATGGAGA
CAGGTTTGATGCCCTGGCTCTGGCCACATCTGCTGCCTTGATGAACATCCGAATCCTTCACATTGAAGGTGGGGAAGTCAGTGGGACCAT
TGATGACTCTATCAGACATGCCATAACAAAACTGGCTCATTATCATGTGTGCTGCACCCGCAGTGCAGAGCAGCACCTGATATCCATGTG
TGAGGACCATGATCGCATCCTTTTGGCAGGCTGCCCTTCCTATGACAAACTTCTCTCAGCCAAGAACAAAGACTACATGAGCATCATTCG
CATGTGGCTAGGTGATGATGTAAAATCTAAAGATTACATTGTTGCACTACAGCACCCTGTGACCACTGACATTAAGCATTCCATAAAAAT
GTTTGAATTAACATTGGATGCACTTATCTCATTTAACAAGCGGACCCTAGTCCTGTTTCCAAATATTGACGCAGGGAGCAAAGAGATGGT
TCGAGTGATGCGGAAGAAGGGCATTGAGCATCATCCCAACTTTCGTGCAGTTAAACACGTCCCATTTGACCAGTTTATACAGTTGGTTGC
CCATGCTGGCTGTATGATTGGGAACAGCAGCTGTGGGGTTCGAGAAGTTGGAGCTTTTGGAACACCTGTGATCAACCTGGGAACACGTCA
GATTGGAAGAGAAACAGGGGAGAATGTTCTTCATGTCCGGGATGCTGACACCCAAGACAAAATATTGCAAGCACTGCACCTTCAGTTTGG
TAAACAGTACCCTTGTTCAAAGATATATGGGGATGGAAATGCTGTTCCAAGGATTTTGAAGTTTCTCAAATCTATCGATCTTCAAGAGCC
ACTGCAAAAGAAATTCTGCTTTCCTCCTGTGAAGGAGAATATCTCTCAAGATATTGACCATATTCTTGAAACTCTAAGTGCCTTGGCCGT
TGATCTTGGCGGGACGAACCTCCGAGTTGCAATAGTCAGCATGAAGGGTGAAATAGTTAAGAAGTATACTCAGTTCAATCCTAAAACCTA
TGAAGAGAGGATTAATTTAATCCTACAGATGTGTGTGGAAGCTGCAGCAGAAGCTGTAAAACTGAACTGCAGAATTTTGGGAGTAGGCAT
TTCCACAGGTGGCCGTGTAAATCCTCGGGAAGGAATTGTGCTGCATTCAACCAAACTGATCCAAGAGTGGAACTCTGTGGACCTTAGGAC
CCCCCTTTCTGACACTTTGCATCTCCCTGTGTGGGTAGACAATGATGGCAACTGTGCTGCCCTGGCGGAAAGGAAATTTGGCCAAGGAAA
GGGACTGGAAAACTTTGTTACACTTATCACAGGCACAGGAATCGGTGGTGGAATTATCCATCAGCATGAATTGATCCACGGAAGCTCCTT
CTGTGCTGCAGAACTGGGCCACCTTGTTGTGTCTCTGGATGGGCCTGATTGTTCCTGTGGAAGCCATGGGTGCATTGAAGCATACGCCTC
TGGAATGGCCTTGCAGAGGGAGGCAAAAAAGCTCCATGATGAGGACCTGCTCTTGGTGGAAGGGATGTCAGTGCCAAAAGATGAGGCTGT
GGGTGCGCTCCATCTCATCCAAGCTGCGAAACTTGGCAATGCGAAGGCCCAGAGCATCCTAAGAACAGGGCTATTGAGTGGCCAGACTTC
CCCAACAAATGCCAAATTGGAGAAACTGGACTCTCAGCAGGTGTTGCAGCTCTGCCTCCGATATCAAGATCACCTGCATCAGTGTGCAGA
GGCCGTTGCTTTTGACCAGAATGCTTTGGTTAAACGAATCAAAGAGATGGATCTGTCTGTAGAAACTCTGTTCAGCTTCATGCAGGAGCG
CCAGAAAAGATACGCCAAGTATGCCGAGCAGATCCAGAAAGTGAACGAGATGTCCGCCATCCTCCGCCGCATACAGATGGGCATCGACCA
GACTGTGCCCCTGCTGGACAGGCTCAACAGCATGCTGCCCGAGGGCGAGCGGCTGGAGCCCTTCAGCATGAAGCCCGACCGCGAGCTCAG
GCTGTAGCTGCTGCCCGGCCTGCCTGGGGCTGGGAGCCCCAGACACCGACACCCTGAGGACGTGTGGAGCTAAGGTCATATCATCTGACC
AGGTCTGGAGGCTGGCGGGAGGCTCCCTGAAAGTGGGTGCGAAGGAGTCCGGCTGGCATGAAAATCTGACTTTGCCCAGCTCTTTTCCTT
GATGCAGTTTCCCGGTGTGGAAGGAACCTAACCAGTTCTCGGTGATAACTGAAGCTGGAACGTGTGAATTATTAGGAATTCTTTGAAGAA
CTCTGCATTGAGAATTATTTTTATTTAGTTTTTTTTTTTTTTTAATTGAGAGTATATAGTCCAGTCCAGGTACCGGAATAAAAATATGGA
GACAAGGGGAAAATATTTTACGAAGCTCTGTGTTCTCAACGCCCTCATGAACTTTTCAGTAGGCTGTCTGGTTTATGTGTGGTCAACTTG
AAAAACTAATTGAATCTAGGTCTCTGTATTGTTCCTGTTTCTACCCTGACTGTTTCCGTCACACCAAGCCCTTATCTGGGGCGCGTCTTC
CTGCCCAGGTGGAACACTGGCATTTTGTTGACTGTCAGGTTAGGTGTCCCTTAGTCGTCATCAGAAGCTGAAGCCTTCCTTTCCACACCC
TCATCAGATTCATCTCCACTGATAACCGGTTTCCTTGATGCAGACATAGTTTAGCTTTCTTTGACTGCAGAGATGTCTCATTCCACAGAC
ATTTCTTGAACCCATTTGATGTGTCCAATATTGTGCCAGGGATACAAATATGGCCGTATAGCCTCAGGCCTTCATTTCTGAAAAGAAAAA
AGCTCAAAAAGCTGCTGAATTTCTCTGGGAGTTTAGGAAAGGAAGTTATTTGAGTAACAACAAAAGTGCTTAGTGTCGTACTTTACACAT
CATAGGTGTTCTAATGGAAGCAAGGACTGGAGAAGCAAAGAGTGGAATGTGAGGAGCAGACCTAGGCAGACACCTTGAGACTAAAAGTCA
GAGCTGAAGGGAGTCGCTGGGGCCAGGACGGCATGCAGGCCTGTACCCTGTTCCCTAAGTTCCTGCAAGCGTCGGGAGGTGTGTTTTCAG

>33727_33727_2_GNE-LOH12CR1_GNE_chr9_36218179_ENST00000396594_LOH12CR1_chr12_12588561_ENST00000314565_length(amino acids)=820AA_BP=691
MLIISNHTRVQSSCFGMETYGYLQRESCFQGPHELYFKNLSKRNKQIMEKNGNNRKLRVCVATCNRADYSKLAPIMFGIKTEPEFFELDV
VVLGSHLIDDYGNTYRMIEQDDFDINTRLHTIVRGEDEAAMVESVGLALVKLPDVLNRLKPDIMIVHGDRFDALALATSAALMNIRILHI
EGGEVSGTIDDSIRHAITKLAHYHVCCTRSAEQHLISMCEDHDRILLAGCPSYDKLLSAKNKDYMSIIRMWLGDDVKSKDYIVALQHPVT
TDIKHSIKMFELTLDALISFNKRTLVLFPNIDAGSKEMVRVMRKKGIEHHPNFRAVKHVPFDQFIQLVAHAGCMIGNSSCGVREVGAFGT
PVINLGTRQIGRETGENVLHVRDADTQDKILQALHLQFGKQYPCSKIYGDGNAVPRILKFLKSIDLQEPLQKKFCFPPVKENISQDIDHI
LETLSALAVDLGGTNLRVAIVSMKGEIVKKYTQFNPKTYEERINLILQMCVEAAAEAVKLNCRILGVGISTGGRVNPREGIVLHSTKLIQ
EWNSVDLRTPLSDTLHLPVWVDNDGNCAALAERKFGQGKGLENFVTLITGTGIGGGIIHQHELIHGSSFCAAELGHLVVSLDGPDCSCGS
HGCIEAYASGMALQREAKKLHDEDLLLVEGMSVPKDEAVGALHLIQAAKLGNAKAQSILRTGLLSGQTSPTNAKLEKLDSQQVLQLCLRY
QDHLHQCAEAVAFDQNALVKRIKEMDLSVETLFSFMQERQKRYAKYAEQIQKVNEMSAILRRIQMGIDQTVPLLDRLNSMLPEGERLEPF

--------------------------------------------------------------
>33727_33727_3_GNE-LOH12CR1_GNE_chr9_36218179_ENST00000396594_LOH12CR1_chr12_12588561_ENST00000542728_length(transcript)=2534nt_BP=2138nt
AGTCTGGAATTCAGATGCCTATTGGTGACTGCTCCGTGGCAGCTAAACCAAGAAAACAGCTGCTCTGCTCATTATTTCAAACCACACTAG
GGTACAGAGCTCGTGCTTCGGGATGGAAACCTATGGTTATCTGCAGAGGGAGTCATGCTTTCAAGGACCTCATGAACTCTATTTTAAGAA
CCTCTCAAAACGAAACAAGCAAATCATGGAGAAGAATGGAAATAACCGAAAGCTGCGGGTTTGTGTTGCTACTTGTAACCGTGCAGATTA
TTCTAAACTTGCCCCGATCATGTTTGGCATTAAAACCGAACCTGAGTTCTTTGAACTTGATGTTGTGGTACTTGGCTCTCACCTGATAGA
TGACTATGGAAATACATATCGAATGATTGAACAAGATGACTTTGACATTAACACCAGGCTACACACAATTGTGAGGGGAGAAGATGAGGC
AGCCATGGTGGAGTCAGTAGGCCTGGCCCTAGTGAAGCTGCCAGATGTCCTTAATCGCCTGAAGCCTGATATCATGATTGTTCATGGAGA
CAGGTTTGATGCCCTGGCTCTGGCCACATCTGCTGCCTTGATGAACATCCGAATCCTTCACATTGAAGGTGGGGAAGTCAGTGGGACCAT
TGATGACTCTATCAGACATGCCATAACAAAACTGGCTCATTATCATGTGTGCTGCACCCGCAGTGCAGAGCAGCACCTGATATCCATGTG
TGAGGACCATGATCGCATCCTTTTGGCAGGCTGCCCTTCCTATGACAAACTTCTCTCAGCCAAGAACAAAGACTACATGAGCATCATTCG
CATGTGGCTAGGTGATGATGTAAAATCTAAAGATTACATTGTTGCACTACAGCACCCTGTGACCACTGACATTAAGCATTCCATAAAAAT
GTTTGAATTAACATTGGATGCACTTATCTCATTTAACAAGCGGACCCTAGTCCTGTTTCCAAATATTGACGCAGGGAGCAAAGAGATGGT
TCGAGTGATGCGGAAGAAGGGCATTGAGCATCATCCCAACTTTCGTGCAGTTAAACACGTCCCATTTGACCAGTTTATACAGTTGGTTGC
CCATGCTGGCTGTATGATTGGGAACAGCAGCTGTGGGGTTCGAGAAGTTGGAGCTTTTGGAACACCTGTGATCAACCTGGGAACACGTCA
GATTGGAAGAGAAACAGGGGAGAATGTTCTTCATGTCCGGGATGCTGACACCCAAGACAAAATATTGCAAGCACTGCACCTTCAGTTTGG
TAAACAGTACCCTTGTTCAAAGATATATGGGGATGGAAATGCTGTTCCAAGGATTTTGAAGTTTCTCAAATCTATCGATCTTCAAGAGCC
ACTGCAAAAGAAATTCTGCTTTCCTCCTGTGAAGGAGAATATCTCTCAAGATATTGACCATATTCTTGAAACTCTAAGTGCCTTGGCCGT
TGATCTTGGCGGGACGAACCTCCGAGTTGCAATAGTCAGCATGAAGGGTGAAATAGTTAAGAAGTATACTCAGTTCAATCCTAAAACCTA
TGAAGAGAGGATTAATTTAATCCTACAGATGTGTGTGGAAGCTGCAGCAGAAGCTGTAAAACTGAACTGCAGAATTTTGGGAGTAGGCAT
TTCCACAGGTGGCCGTGTAAATCCTCGGGAAGGAATTGTGCTGCATTCAACCAAACTGATCCAAGAGTGGAACTCTGTGGACCTTAGGAC
CCCCCTTTCTGACACTTTGCATCTCCCTGTGTGGGTAGACAATGATGGCAACTGTGCTGCCCTGGCGGAAAGGAAATTTGGCCAAGGAAA
GGGACTGGAAAACTTTGTTACACTTATCACAGGCACAGGAATCGGTGGTGGAATTATCCATCAGCATGAATTGATCCACGGAAGCTCCTT
CTGTGCTGCAGAACTGGGCCACCTTGTTGTGTCTCTGGATGGGCCTGATTGTTCCTGTGGAAGCCATGGGTGCATTGAAGCATACGCCTC
TGGAATGGCCTTGCAGAGGGAGGCAAAAAAGCTCCATGATGAGGACCTGCTCTTGGTGGAAGGGATGTCAGTGCCAAAAGATGAGGCTGT
GGGTGCGCTCCATCTCATCCAAGCTGCGAAACTTGGCAATGCGAAGGCCCAGAGCATCCTAAGAACAGGGCTATTGAGTGGCCAGACTTC
CCCAACAAATGCCAAATTGGAGAAACTGGACTCTCAGCAGGTGTTGCAGCTCTGCCTCCGATATCAAGATCACCTGCATCAGTGTGCAGA
GGCCGTTGCTTTTGACCAGAATGCTTTGGTTAAACGAATCAAAGAGATGGATCTGTCTGTAGAAACTCTGTTCAGCTTCATGCAGGAGCG
CCAGAAAAGATACGCCAAGTATGCCGAGCAGATCCAGAAAGTGAACGAGATGTCCGCCATCCTCCGCCGCATACAGATGGGCATCGACCA
GACTGTGCCCCTGCTGGACAGGCTCAACAGCATGCTGCCCGAGGGCGAGCGGCTGGAGCCCTTCAGCATGAAGCCCGACCGCGAGCTCAG

>33727_33727_3_GNE-LOH12CR1_GNE_chr9_36218179_ENST00000396594_LOH12CR1_chr12_12588561_ENST00000542728_length(amino acids)=820AA_BP=691
MLIISNHTRVQSSCFGMETYGYLQRESCFQGPHELYFKNLSKRNKQIMEKNGNNRKLRVCVATCNRADYSKLAPIMFGIKTEPEFFELDV
VVLGSHLIDDYGNTYRMIEQDDFDINTRLHTIVRGEDEAAMVESVGLALVKLPDVLNRLKPDIMIVHGDRFDALALATSAALMNIRILHI
EGGEVSGTIDDSIRHAITKLAHYHVCCTRSAEQHLISMCEDHDRILLAGCPSYDKLLSAKNKDYMSIIRMWLGDDVKSKDYIVALQHPVT
TDIKHSIKMFELTLDALISFNKRTLVLFPNIDAGSKEMVRVMRKKGIEHHPNFRAVKHVPFDQFIQLVAHAGCMIGNSSCGVREVGAFGT
PVINLGTRQIGRETGENVLHVRDADTQDKILQALHLQFGKQYPCSKIYGDGNAVPRILKFLKSIDLQEPLQKKFCFPPVKENISQDIDHI
LETLSALAVDLGGTNLRVAIVSMKGEIVKKYTQFNPKTYEERINLILQMCVEAAAEAVKLNCRILGVGISTGGRVNPREGIVLHSTKLIQ
EWNSVDLRTPLSDTLHLPVWVDNDGNCAALAERKFGQGKGLENFVTLITGTGIGGGIIHQHELIHGSSFCAAELGHLVVSLDGPDCSCGS
HGCIEAYASGMALQREAKKLHDEDLLLVEGMSVPKDEAVGALHLIQAAKLGNAKAQSILRTGLLSGQTSPTNAKLEKLDSQQVLQLCLRY
QDHLHQCAEAVAFDQNALVKRIKEMDLSVETLFSFMQERQKRYAKYAEQIQKVNEMSAILRRIQMGIDQTVPLLDRLNSMLPEGERLEPF

--------------------------------------------------------------
>33727_33727_4_GNE-LOH12CR1_GNE_chr9_36218179_ENST00000539208_LOH12CR1_chr12_12588561_ENST00000298571_length(transcript)=2198nt_BP=1741nt
TACCCGCGCGCCCGAGCGCGGAAACCGAGGGGCAGGCTCGCGCTCTGCCTGCTTCGTGGCGCTTGGTTCGTCCCTCGCCCGAGGAGCGCG
GTGGCGGCGTGGGAGGGAGCCTCTGACGGCGTCTGAAATACATATCGAATGATTGAACAAGATGACTTTGACATTAACACCAGGCTACAC
ACAATTGTGAGGGGAGAAGATGAGGCAGCCATGGTGGAGTCAGTAGGCCTGGCCCTAGTGAAGCTGCCAGATGTCCTTAATCGCCTGAAG
CCTGATATCATGATTGTTCATGGAGACAGGTTTGATGCCCTGGCTCTGGCCACATCTGCTGCCTTGATGAACATCCGAATCCTTCACATT
GAAGGTGGGGAAGTCAGTGGGACCATTGATGACTCTATCAGACATGCCATAACAAAACTGGCTCATTATCATGTGTGCTGCACCCGCAGT
GCAGAGCAGCACCTGATATCCATGTGTGAGGACCATGATCGCATCCTTTTGGCAGGCTGCCCTTCCTATGACAAACTTCTCTCAGCCAAG
AACAAAGACTACATGAGCATCATTCGCATGTGGCTAGGGAGCAAAGAGATGGTTCGAGTGATGCGGAAGAAGGGCATTGAGCATCATCCC
AACTTTCGTGCAGTTAAACACGTCCCATTTGACCAGTTTATACAGTTGGTTGCCCATGCTGGCTGTATGATTGGGAACAGCAGCTGTGGG
GTTCGAGAAGTTGGAGCTTTTGGAACACCTGTGATCAACCTGGGAACACGTCAGATTGGAAGAGAAACAGGGGAGAATGTTCTTCATGTC
CGGGATGCTGACACCCAAGACAAAATATTGCAAGCACTGCACCTTCAGTTTGGTAAACAGTACCCTTGTTCAAAGATATATGGGGATGGA
AATGCTGTTCCAAGGATTTTGAAGTTTCTCAAATCTATCGATCTTCAAGAGCCACTGCAAAAGAAATTCTGCTTTCCTCCTGTGAAGGAG
AATATCTCTCAAGATATTGACCATATTCTTGAAACTCTAAGTGCCTTGGCCGTTGATCTTGGCGGGACGAACCTCCGAGTTGCAATAGTC
AGCATGAAGGGTGAAATAGTTAAGAAGTATACTCAGTTCAATCCTAAAACCTATGAAGAGAGGATTAATTTAATCCTACAGATGTGTGTG
GAAGCTGCAGCAGAAGCTGTAAAACTGAACTGCAGAATTTTGGGAGTAGGCATTTCCACAGGTGGCCGTGTAAATCCTCGGGAAGGAATT
GTGCTGCATTCAACCAAACTGATCCAAGAGTGGAACTCTGTGGACCTTAGGACCCCCCTTTCTGACACTTTGCATCTCCCTGTGTGGGTA
GACAATGATGGCAACTGTGCTGCCCTGGCGGAAAGGAAATTTGGCCAAGGAAAGGGACTGGAAAACTTTGTTACACTTATCACAGGCACA
GGAATCGGTGGTGGAATTATCCATCAGCATGAATTGATCCACGGAAGCTCCTTCTGTGCTGCAGAACTGGGCCACCTTGTTGTGTCTCTG
GATGGGCCTGATTGTTCCTGTGGAAGCCATGGGTGCATTGAAGCATACGCCTCTGGAATGGCCTTGCAGAGGGAGGCAAAAAAGCTCCAT
GATGAGGACCTGCTCTTGGTGGAAGGGATGTCAGTGCCAAAAGATGAGGCTGTGGGTGCGCTCCATCTCATCCAAGCTGCGAAACTTGGC
AATGCGAAGGCCCAGAGCATCCTAAGAACAGGGCTATTGAGTGGCCAGACTTCCCCAACAAATGCCAAATTGGAGAAACTGGACTCTCAG
CAGGTGTTGCAGCTCTGCCTCCGATATCAAGATCACCTGCATCAGTGTGCAGAGGCCGTTGCTTTTGACCAGAATGCTTTGGTTAAACGA
ATCAAAGAGATGGATCTGTCTGTAGAAACTCTGTTCAGCTTCATGCAGGAGCGCCAGAAAAGATACGCCAAGTATGCCGAGCAGATCCAG
AAAGTGAACGAGATGTCCGCCATCCTCCGCCGCATACAGATGGGCATCGACCAGACTGTGCCCCTGCTGGACAGGCTCAACAGCATGCTG
CCCGAGGGCGAGCGGCTGGAGCCCTTCAGCATGAAGCCCGACCGCGAGCTCAGGCTGTAGCTGCTGCCCGGCCTGCCTGGGGCTGGGAGC

>33727_33727_4_GNE-LOH12CR1_GNE_chr9_36218179_ENST00000539208_LOH12CR1_chr12_12588561_ENST00000298571_length(amino acids)=663AA_BP=534
MIEQDDFDINTRLHTIVRGEDEAAMVESVGLALVKLPDVLNRLKPDIMIVHGDRFDALALATSAALMNIRILHIEGGEVSGTIDDSIRHA
ITKLAHYHVCCTRSAEQHLISMCEDHDRILLAGCPSYDKLLSAKNKDYMSIIRMWLGSKEMVRVMRKKGIEHHPNFRAVKHVPFDQFIQL
VAHAGCMIGNSSCGVREVGAFGTPVINLGTRQIGRETGENVLHVRDADTQDKILQALHLQFGKQYPCSKIYGDGNAVPRILKFLKSIDLQ
EPLQKKFCFPPVKENISQDIDHILETLSALAVDLGGTNLRVAIVSMKGEIVKKYTQFNPKTYEERINLILQMCVEAAAEAVKLNCRILGV
GISTGGRVNPREGIVLHSTKLIQEWNSVDLRTPLSDTLHLPVWVDNDGNCAALAERKFGQGKGLENFVTLITGTGIGGGIIHQHELIHGS
SFCAAELGHLVVSLDGPDCSCGSHGCIEAYASGMALQREAKKLHDEDLLLVEGMSVPKDEAVGALHLIQAAKLGNAKAQSILRTGLLSGQ
TSPTNAKLEKLDSQQVLQLCLRYQDHLHQCAEAVAFDQNALVKRIKEMDLSVETLFSFMQERQKRYAKYAEQIQKVNEMSAILRRIQMGI

--------------------------------------------------------------
>33727_33727_5_GNE-LOH12CR1_GNE_chr9_36218179_ENST00000539208_LOH12CR1_chr12_12588561_ENST00000314565_length(transcript)=3260nt_BP=1741nt
TACCCGCGCGCCCGAGCGCGGAAACCGAGGGGCAGGCTCGCGCTCTGCCTGCTTCGTGGCGCTTGGTTCGTCCCTCGCCCGAGGAGCGCG
GTGGCGGCGTGGGAGGGAGCCTCTGACGGCGTCTGAAATACATATCGAATGATTGAACAAGATGACTTTGACATTAACACCAGGCTACAC
ACAATTGTGAGGGGAGAAGATGAGGCAGCCATGGTGGAGTCAGTAGGCCTGGCCCTAGTGAAGCTGCCAGATGTCCTTAATCGCCTGAAG
CCTGATATCATGATTGTTCATGGAGACAGGTTTGATGCCCTGGCTCTGGCCACATCTGCTGCCTTGATGAACATCCGAATCCTTCACATT
GAAGGTGGGGAAGTCAGTGGGACCATTGATGACTCTATCAGACATGCCATAACAAAACTGGCTCATTATCATGTGTGCTGCACCCGCAGT
GCAGAGCAGCACCTGATATCCATGTGTGAGGACCATGATCGCATCCTTTTGGCAGGCTGCCCTTCCTATGACAAACTTCTCTCAGCCAAG
AACAAAGACTACATGAGCATCATTCGCATGTGGCTAGGGAGCAAAGAGATGGTTCGAGTGATGCGGAAGAAGGGCATTGAGCATCATCCC
AACTTTCGTGCAGTTAAACACGTCCCATTTGACCAGTTTATACAGTTGGTTGCCCATGCTGGCTGTATGATTGGGAACAGCAGCTGTGGG
GTTCGAGAAGTTGGAGCTTTTGGAACACCTGTGATCAACCTGGGAACACGTCAGATTGGAAGAGAAACAGGGGAGAATGTTCTTCATGTC
CGGGATGCTGACACCCAAGACAAAATATTGCAAGCACTGCACCTTCAGTTTGGTAAACAGTACCCTTGTTCAAAGATATATGGGGATGGA
AATGCTGTTCCAAGGATTTTGAAGTTTCTCAAATCTATCGATCTTCAAGAGCCACTGCAAAAGAAATTCTGCTTTCCTCCTGTGAAGGAG
AATATCTCTCAAGATATTGACCATATTCTTGAAACTCTAAGTGCCTTGGCCGTTGATCTTGGCGGGACGAACCTCCGAGTTGCAATAGTC
AGCATGAAGGGTGAAATAGTTAAGAAGTATACTCAGTTCAATCCTAAAACCTATGAAGAGAGGATTAATTTAATCCTACAGATGTGTGTG
GAAGCTGCAGCAGAAGCTGTAAAACTGAACTGCAGAATTTTGGGAGTAGGCATTTCCACAGGTGGCCGTGTAAATCCTCGGGAAGGAATT
GTGCTGCATTCAACCAAACTGATCCAAGAGTGGAACTCTGTGGACCTTAGGACCCCCCTTTCTGACACTTTGCATCTCCCTGTGTGGGTA
GACAATGATGGCAACTGTGCTGCCCTGGCGGAAAGGAAATTTGGCCAAGGAAAGGGACTGGAAAACTTTGTTACACTTATCACAGGCACA
GGAATCGGTGGTGGAATTATCCATCAGCATGAATTGATCCACGGAAGCTCCTTCTGTGCTGCAGAACTGGGCCACCTTGTTGTGTCTCTG
GATGGGCCTGATTGTTCCTGTGGAAGCCATGGGTGCATTGAAGCATACGCCTCTGGAATGGCCTTGCAGAGGGAGGCAAAAAAGCTCCAT
GATGAGGACCTGCTCTTGGTGGAAGGGATGTCAGTGCCAAAAGATGAGGCTGTGGGTGCGCTCCATCTCATCCAAGCTGCGAAACTTGGC
AATGCGAAGGCCCAGAGCATCCTAAGAACAGGGCTATTGAGTGGCCAGACTTCCCCAACAAATGCCAAATTGGAGAAACTGGACTCTCAG
CAGGTGTTGCAGCTCTGCCTCCGATATCAAGATCACCTGCATCAGTGTGCAGAGGCCGTTGCTTTTGACCAGAATGCTTTGGTTAAACGA
ATCAAAGAGATGGATCTGTCTGTAGAAACTCTGTTCAGCTTCATGCAGGAGCGCCAGAAAAGATACGCCAAGTATGCCGAGCAGATCCAG
AAAGTGAACGAGATGTCCGCCATCCTCCGCCGCATACAGATGGGCATCGACCAGACTGTGCCCCTGCTGGACAGGCTCAACAGCATGCTG
CCCGAGGGCGAGCGGCTGGAGCCCTTCAGCATGAAGCCCGACCGCGAGCTCAGGCTGTAGCTGCTGCCCGGCCTGCCTGGGGCTGGGAGC
CCCAGACACCGACACCCTGAGGACGTGTGGAGCTAAGGTCATATCATCTGACCAGGTCTGGAGGCTGGCGGGAGGCTCCCTGAAAGTGGG
TGCGAAGGAGTCCGGCTGGCATGAAAATCTGACTTTGCCCAGCTCTTTTCCTTGATGCAGTTTCCCGGTGTGGAAGGAACCTAACCAGTT
CTCGGTGATAACTGAAGCTGGAACGTGTGAATTATTAGGAATTCTTTGAAGAACTCTGCATTGAGAATTATTTTTATTTAGTTTTTTTTT
TTTTTTAATTGAGAGTATATAGTCCAGTCCAGGTACCGGAATAAAAATATGGAGACAAGGGGAAAATATTTTACGAAGCTCTGTGTTCTC
AACGCCCTCATGAACTTTTCAGTAGGCTGTCTGGTTTATGTGTGGTCAACTTGAAAAACTAATTGAATCTAGGTCTCTGTATTGTTCCTG
TTTCTACCCTGACTGTTTCCGTCACACCAAGCCCTTATCTGGGGCGCGTCTTCCTGCCCAGGTGGAACACTGGCATTTTGTTGACTGTCA
GGTTAGGTGTCCCTTAGTCGTCATCAGAAGCTGAAGCCTTCCTTTCCACACCCTCATCAGATTCATCTCCACTGATAACCGGTTTCCTTG
ATGCAGACATAGTTTAGCTTTCTTTGACTGCAGAGATGTCTCATTCCACAGACATTTCTTGAACCCATTTGATGTGTCCAATATTGTGCC
AGGGATACAAATATGGCCGTATAGCCTCAGGCCTTCATTTCTGAAAAGAAAAAAGCTCAAAAAGCTGCTGAATTTCTCTGGGAGTTTAGG
AAAGGAAGTTATTTGAGTAACAACAAAAGTGCTTAGTGTCGTACTTTACACATCATAGGTGTTCTAATGGAAGCAAGGACTGGAGAAGCA
AAGAGTGGAATGTGAGGAGCAGACCTAGGCAGACACCTTGAGACTAAAAGTCAGAGCTGAAGGGAGTCGCTGGGGCCAGGACGGCATGCA
GGCCTGTACCCTGTTCCCTAAGTTCCTGCAAGCGTCGGGAGGTGTGTTTTCAGATACCAGAAAGAGCCTTCAGTAGATTCACAAGATTAA

>33727_33727_5_GNE-LOH12CR1_GNE_chr9_36218179_ENST00000539208_LOH12CR1_chr12_12588561_ENST00000314565_length(amino acids)=663AA_BP=534
MIEQDDFDINTRLHTIVRGEDEAAMVESVGLALVKLPDVLNRLKPDIMIVHGDRFDALALATSAALMNIRILHIEGGEVSGTIDDSIRHA
ITKLAHYHVCCTRSAEQHLISMCEDHDRILLAGCPSYDKLLSAKNKDYMSIIRMWLGSKEMVRVMRKKGIEHHPNFRAVKHVPFDQFIQL
VAHAGCMIGNSSCGVREVGAFGTPVINLGTRQIGRETGENVLHVRDADTQDKILQALHLQFGKQYPCSKIYGDGNAVPRILKFLKSIDLQ
EPLQKKFCFPPVKENISQDIDHILETLSALAVDLGGTNLRVAIVSMKGEIVKKYTQFNPKTYEERINLILQMCVEAAAEAVKLNCRILGV
GISTGGRVNPREGIVLHSTKLIQEWNSVDLRTPLSDTLHLPVWVDNDGNCAALAERKFGQGKGLENFVTLITGTGIGGGIIHQHELIHGS
SFCAAELGHLVVSLDGPDCSCGSHGCIEAYASGMALQREAKKLHDEDLLLVEGMSVPKDEAVGALHLIQAAKLGNAKAQSILRTGLLSGQ
TSPTNAKLEKLDSQQVLQLCLRYQDHLHQCAEAVAFDQNALVKRIKEMDLSVETLFSFMQERQKRYAKYAEQIQKVNEMSAILRRIQMGI

--------------------------------------------------------------
>33727_33727_6_GNE-LOH12CR1_GNE_chr9_36218179_ENST00000539208_LOH12CR1_chr12_12588561_ENST00000542728_length(transcript)=2137nt_BP=1741nt
TACCCGCGCGCCCGAGCGCGGAAACCGAGGGGCAGGCTCGCGCTCTGCCTGCTTCGTGGCGCTTGGTTCGTCCCTCGCCCGAGGAGCGCG
GTGGCGGCGTGGGAGGGAGCCTCTGACGGCGTCTGAAATACATATCGAATGATTGAACAAGATGACTTTGACATTAACACCAGGCTACAC
ACAATTGTGAGGGGAGAAGATGAGGCAGCCATGGTGGAGTCAGTAGGCCTGGCCCTAGTGAAGCTGCCAGATGTCCTTAATCGCCTGAAG
CCTGATATCATGATTGTTCATGGAGACAGGTTTGATGCCCTGGCTCTGGCCACATCTGCTGCCTTGATGAACATCCGAATCCTTCACATT
GAAGGTGGGGAAGTCAGTGGGACCATTGATGACTCTATCAGACATGCCATAACAAAACTGGCTCATTATCATGTGTGCTGCACCCGCAGT
GCAGAGCAGCACCTGATATCCATGTGTGAGGACCATGATCGCATCCTTTTGGCAGGCTGCCCTTCCTATGACAAACTTCTCTCAGCCAAG
AACAAAGACTACATGAGCATCATTCGCATGTGGCTAGGGAGCAAAGAGATGGTTCGAGTGATGCGGAAGAAGGGCATTGAGCATCATCCC
AACTTTCGTGCAGTTAAACACGTCCCATTTGACCAGTTTATACAGTTGGTTGCCCATGCTGGCTGTATGATTGGGAACAGCAGCTGTGGG
GTTCGAGAAGTTGGAGCTTTTGGAACACCTGTGATCAACCTGGGAACACGTCAGATTGGAAGAGAAACAGGGGAGAATGTTCTTCATGTC
CGGGATGCTGACACCCAAGACAAAATATTGCAAGCACTGCACCTTCAGTTTGGTAAACAGTACCCTTGTTCAAAGATATATGGGGATGGA
AATGCTGTTCCAAGGATTTTGAAGTTTCTCAAATCTATCGATCTTCAAGAGCCACTGCAAAAGAAATTCTGCTTTCCTCCTGTGAAGGAG
AATATCTCTCAAGATATTGACCATATTCTTGAAACTCTAAGTGCCTTGGCCGTTGATCTTGGCGGGACGAACCTCCGAGTTGCAATAGTC
AGCATGAAGGGTGAAATAGTTAAGAAGTATACTCAGTTCAATCCTAAAACCTATGAAGAGAGGATTAATTTAATCCTACAGATGTGTGTG
GAAGCTGCAGCAGAAGCTGTAAAACTGAACTGCAGAATTTTGGGAGTAGGCATTTCCACAGGTGGCCGTGTAAATCCTCGGGAAGGAATT
GTGCTGCATTCAACCAAACTGATCCAAGAGTGGAACTCTGTGGACCTTAGGACCCCCCTTTCTGACACTTTGCATCTCCCTGTGTGGGTA
GACAATGATGGCAACTGTGCTGCCCTGGCGGAAAGGAAATTTGGCCAAGGAAAGGGACTGGAAAACTTTGTTACACTTATCACAGGCACA
GGAATCGGTGGTGGAATTATCCATCAGCATGAATTGATCCACGGAAGCTCCTTCTGTGCTGCAGAACTGGGCCACCTTGTTGTGTCTCTG
GATGGGCCTGATTGTTCCTGTGGAAGCCATGGGTGCATTGAAGCATACGCCTCTGGAATGGCCTTGCAGAGGGAGGCAAAAAAGCTCCAT
GATGAGGACCTGCTCTTGGTGGAAGGGATGTCAGTGCCAAAAGATGAGGCTGTGGGTGCGCTCCATCTCATCCAAGCTGCGAAACTTGGC
AATGCGAAGGCCCAGAGCATCCTAAGAACAGGGCTATTGAGTGGCCAGACTTCCCCAACAAATGCCAAATTGGAGAAACTGGACTCTCAG
CAGGTGTTGCAGCTCTGCCTCCGATATCAAGATCACCTGCATCAGTGTGCAGAGGCCGTTGCTTTTGACCAGAATGCTTTGGTTAAACGA
ATCAAAGAGATGGATCTGTCTGTAGAAACTCTGTTCAGCTTCATGCAGGAGCGCCAGAAAAGATACGCCAAGTATGCCGAGCAGATCCAG
AAAGTGAACGAGATGTCCGCCATCCTCCGCCGCATACAGATGGGCATCGACCAGACTGTGCCCCTGCTGGACAGGCTCAACAGCATGCTG

>33727_33727_6_GNE-LOH12CR1_GNE_chr9_36218179_ENST00000539208_LOH12CR1_chr12_12588561_ENST00000542728_length(amino acids)=663AA_BP=534
MIEQDDFDINTRLHTIVRGEDEAAMVESVGLALVKLPDVLNRLKPDIMIVHGDRFDALALATSAALMNIRILHIEGGEVSGTIDDSIRHA
ITKLAHYHVCCTRSAEQHLISMCEDHDRILLAGCPSYDKLLSAKNKDYMSIIRMWLGSKEMVRVMRKKGIEHHPNFRAVKHVPFDQFIQL
VAHAGCMIGNSSCGVREVGAFGTPVINLGTRQIGRETGENVLHVRDADTQDKILQALHLQFGKQYPCSKIYGDGNAVPRILKFLKSIDLQ
EPLQKKFCFPPVKENISQDIDHILETLSALAVDLGGTNLRVAIVSMKGEIVKKYTQFNPKTYEERINLILQMCVEAAAEAVKLNCRILGV
GISTGGRVNPREGIVLHSTKLIQEWNSVDLRTPLSDTLHLPVWVDNDGNCAALAERKFGQGKGLENFVTLITGTGIGGGIIHQHELIHGS
SFCAAELGHLVVSLDGPDCSCGSHGCIEAYASGMALQREAKKLHDEDLLLVEGMSVPKDEAVGALHLIQAAKLGNAKAQSILRTGLLSGQ
TSPTNAKLEKLDSQQVLQLCLRYQDHLHQCAEAVAFDQNALVKRIKEMDLSVETLFSFMQERQKRYAKYAEQIQKVNEMSAILRRIQMGI

--------------------------------------------------------------
>33727_33727_7_GNE-LOH12CR1_GNE_chr9_36218179_ENST00000539815_LOH12CR1_chr12_12588561_ENST00000298571_length(transcript)=2431nt_BP=1974nt
AACTCTATTTTAAGAACCTCTCAAAACGAAACAAGCAAATCATGGAGAAGAATGGAAATAACCGAAAGCTGCGGGTTTGTGTTGCTACTT
GTAACCGTGCAGATTATTCTAAACTTGCCCCGATCATGTTTGGCATTAAAACCGAACCTGAGTTCTTTGAACTTGATGTTGTGGTACTTG
GCTCTCACCTGATAGATGACTATGGAAATACATATCGAATGATTGAACAAGATGACTTTGACATTAACACCAGGCTACACACAATTGTGA
GGGGAGAAGATGAGGCAGCCATGGTGGAGTCAGTAGGCCTGGCCCTAGTGAAGCTGCCAGATGTCCTTAATCGCCTGAAGCCTGATATCA
TGATTGTTCATGGAGACAGGTTTGATGCCCTGGCTCTGGCCACATCTGCTGCCTTGATGAACATCCGAATCCTTCACATTGAAGGTGGGG
AAGTCAGTGGGACCATTGATGACTCTATCAGACATGCCATAACAAAACTGGCTCATTATCATGTGTGCTGCACCCGCAGTGCAGAGCAGC
ACCTGATATCCATGTGTGAGGACCATGATCGCATCCTTTTGGCAGGCTGCCCTTCCTATGACAAACTTCTCTCAGCCAAGAACAAAGACT
ACATGAGCATCATTCGCATGTGGCTAGGTGATGATGTAAAATCTAAAGATTACATTGTTGCACTACAGCACCCTGTGACCACTGACATTA
AGCATTCCATAAAAATGTTTGAATTAACATTGGATGCACTTATCTCATTTAACAAGCGGACCCTAGTCCTGTTTCCAAATATTGACGCAG
GGAGCAAAGAGATGGTTCGAGTGATGCGGAAGAAGGGCATTGAGCATCATCCCAACTTTCGTGCAGTTAAACACGTCCCATTTGACCAGT
TTATACAGTTGGTTGCCCATGCTGGCTGTATGATTGGGAACAGCAGCTGTGGGGTTCGAGAAGTTGGAGCTTTTGGAACACCTGTGATCA
ACCTGGGAACACGTCAGATTGGAAGAGAAACAGGGGAGAATGTTCTTCATGTCCGGGATGCTGACACCCAAGACAAAATATTGCAAGCAC
TGCACCTTCAGTTTGGTAAACAGTACCCTTGTTCAAAGATATATGGGGATGGAAATGCTGTTCCAAGGATTTTGAAGTTTCTCAAATCTA
TCGATCTTCAAGAGCCACTGCAAAAGAAATTCTGCTTTCCTCCTGTGAAGGAGAATATCTCTCAAGATATTGACCATATTCTTGAAACTC
TAAGTGCCTTGGCCGTTGATCTTGGCGGGACGAACCTCCGAGTTGCAATAGTCAGCATGAAGGGTGAAATAGTTAAGAAGTATACTCAGT
TCAATCCTAAAACCTATGAAGAGAGGATTAATTTAATCCTACAGATGTGTGTGGAAGCTGCAGCAGAAGCTGTAAAACTGAACTGCAGAA
TTTTGGGAGTAGGCATTTCCACAGGTGGCCGTGTAAATCCTCGGGAAGGAATTGTGCTGCATTCAACCAAACTGATCCAAGAGTGGAACT
CTGTGGACCTTAGGACCCCCCTTTCTGACACTTTGCATCTCCCTGTGTGGGTAGACAATGATGGCAACTGTGCTGCCCTGGCGGAAAGGA
AATTTGGCCAAGGAAAGGGACTGGAAAACTTTGTTACACTTATCACAGGCACAGGAATCGGTGGTGGAATTATCCATCAGCATGAATTGA
TCCACGGAAGCTCCTTCTGTGCTGCAGAACTGGGCCACCTTGTTGTGTCTCTGGATGGGCCTGATTGTTCCTGTGGAAGCCATGGGTGCA
TTGAAGCATACGCCTCTGGAATGGCCTTGCAGAGGGAGGCAAAAAAGCTCCATGATGAGGACCTGCTCTTGGTGGAAGGGATGTCAGTGC
CAAAAGATGAGGCTGTGGGTGCGCTCCATCTCATCCAAGCTGCGAAACTTGGCAATGCGAAGGCCCAGAGCATCCTAAGAACAGGGCTAT
TGAGTGGCCAGACTTCCCCAACAAATGCCAAATTGGAGAAACTGGACTCTCAGCAGGTGTTGCAGCTCTGCCTCCGATATCAAGATCACC
TGCATCAGTGTGCAGAGGCCGTTGCTTTTGACCAGAATGCTTTGGTTAAACGAATCAAAGAGATGGATCTGTCTGTAGAAACTCTGTTCA
GCTTCATGCAGGAGCGCCAGAAAAGATACGCCAAGTATGCCGAGCAGATCCAGAAAGTGAACGAGATGTCCGCCATCCTCCGCCGCATAC
AGATGGGCATCGACCAGACTGTGCCCCTGCTGGACAGGCTCAACAGCATGCTGCCCGAGGGCGAGCGGCTGGAGCCCTTCAGCATGAAGC
CCGACCGCGAGCTCAGGCTGTAGCTGCTGCCCGGCCTGCCTGGGGCTGGGAGCCCCAGACACCGACACCCTGAGGACGTGTGGAGCTAAG

>33727_33727_7_GNE-LOH12CR1_GNE_chr9_36218179_ENST00000539815_LOH12CR1_chr12_12588561_ENST00000298571_length(amino acids)=773AA_BP=644
MEKNGNNRKLRVCVATCNRADYSKLAPIMFGIKTEPEFFELDVVVLGSHLIDDYGNTYRMIEQDDFDINTRLHTIVRGEDEAAMVESVGL
ALVKLPDVLNRLKPDIMIVHGDRFDALALATSAALMNIRILHIEGGEVSGTIDDSIRHAITKLAHYHVCCTRSAEQHLISMCEDHDRILL
AGCPSYDKLLSAKNKDYMSIIRMWLGDDVKSKDYIVALQHPVTTDIKHSIKMFELTLDALISFNKRTLVLFPNIDAGSKEMVRVMRKKGI
EHHPNFRAVKHVPFDQFIQLVAHAGCMIGNSSCGVREVGAFGTPVINLGTRQIGRETGENVLHVRDADTQDKILQALHLQFGKQYPCSKI
YGDGNAVPRILKFLKSIDLQEPLQKKFCFPPVKENISQDIDHILETLSALAVDLGGTNLRVAIVSMKGEIVKKYTQFNPKTYEERINLIL
QMCVEAAAEAVKLNCRILGVGISTGGRVNPREGIVLHSTKLIQEWNSVDLRTPLSDTLHLPVWVDNDGNCAALAERKFGQGKGLENFVTL
ITGTGIGGGIIHQHELIHGSSFCAAELGHLVVSLDGPDCSCGSHGCIEAYASGMALQREAKKLHDEDLLLVEGMSVPKDEAVGALHLIQA
AKLGNAKAQSILRTGLLSGQTSPTNAKLEKLDSQQVLQLCLRYQDHLHQCAEAVAFDQNALVKRIKEMDLSVETLFSFMQERQKRYAKYA

--------------------------------------------------------------
>33727_33727_8_GNE-LOH12CR1_GNE_chr9_36218179_ENST00000539815_LOH12CR1_chr12_12588561_ENST00000314565_length(transcript)=3493nt_BP=1974nt
AACTCTATTTTAAGAACCTCTCAAAACGAAACAAGCAAATCATGGAGAAGAATGGAAATAACCGAAAGCTGCGGGTTTGTGTTGCTACTT
GTAACCGTGCAGATTATTCTAAACTTGCCCCGATCATGTTTGGCATTAAAACCGAACCTGAGTTCTTTGAACTTGATGTTGTGGTACTTG
GCTCTCACCTGATAGATGACTATGGAAATACATATCGAATGATTGAACAAGATGACTTTGACATTAACACCAGGCTACACACAATTGTGA
GGGGAGAAGATGAGGCAGCCATGGTGGAGTCAGTAGGCCTGGCCCTAGTGAAGCTGCCAGATGTCCTTAATCGCCTGAAGCCTGATATCA
TGATTGTTCATGGAGACAGGTTTGATGCCCTGGCTCTGGCCACATCTGCTGCCTTGATGAACATCCGAATCCTTCACATTGAAGGTGGGG
AAGTCAGTGGGACCATTGATGACTCTATCAGACATGCCATAACAAAACTGGCTCATTATCATGTGTGCTGCACCCGCAGTGCAGAGCAGC
ACCTGATATCCATGTGTGAGGACCATGATCGCATCCTTTTGGCAGGCTGCCCTTCCTATGACAAACTTCTCTCAGCCAAGAACAAAGACT
ACATGAGCATCATTCGCATGTGGCTAGGTGATGATGTAAAATCTAAAGATTACATTGTTGCACTACAGCACCCTGTGACCACTGACATTA
AGCATTCCATAAAAATGTTTGAATTAACATTGGATGCACTTATCTCATTTAACAAGCGGACCCTAGTCCTGTTTCCAAATATTGACGCAG
GGAGCAAAGAGATGGTTCGAGTGATGCGGAAGAAGGGCATTGAGCATCATCCCAACTTTCGTGCAGTTAAACACGTCCCATTTGACCAGT
TTATACAGTTGGTTGCCCATGCTGGCTGTATGATTGGGAACAGCAGCTGTGGGGTTCGAGAAGTTGGAGCTTTTGGAACACCTGTGATCA
ACCTGGGAACACGTCAGATTGGAAGAGAAACAGGGGAGAATGTTCTTCATGTCCGGGATGCTGACACCCAAGACAAAATATTGCAAGCAC
TGCACCTTCAGTTTGGTAAACAGTACCCTTGTTCAAAGATATATGGGGATGGAAATGCTGTTCCAAGGATTTTGAAGTTTCTCAAATCTA
TCGATCTTCAAGAGCCACTGCAAAAGAAATTCTGCTTTCCTCCTGTGAAGGAGAATATCTCTCAAGATATTGACCATATTCTTGAAACTC
TAAGTGCCTTGGCCGTTGATCTTGGCGGGACGAACCTCCGAGTTGCAATAGTCAGCATGAAGGGTGAAATAGTTAAGAAGTATACTCAGT
TCAATCCTAAAACCTATGAAGAGAGGATTAATTTAATCCTACAGATGTGTGTGGAAGCTGCAGCAGAAGCTGTAAAACTGAACTGCAGAA
TTTTGGGAGTAGGCATTTCCACAGGTGGCCGTGTAAATCCTCGGGAAGGAATTGTGCTGCATTCAACCAAACTGATCCAAGAGTGGAACT
CTGTGGACCTTAGGACCCCCCTTTCTGACACTTTGCATCTCCCTGTGTGGGTAGACAATGATGGCAACTGTGCTGCCCTGGCGGAAAGGA
AATTTGGCCAAGGAAAGGGACTGGAAAACTTTGTTACACTTATCACAGGCACAGGAATCGGTGGTGGAATTATCCATCAGCATGAATTGA
TCCACGGAAGCTCCTTCTGTGCTGCAGAACTGGGCCACCTTGTTGTGTCTCTGGATGGGCCTGATTGTTCCTGTGGAAGCCATGGGTGCA
TTGAAGCATACGCCTCTGGAATGGCCTTGCAGAGGGAGGCAAAAAAGCTCCATGATGAGGACCTGCTCTTGGTGGAAGGGATGTCAGTGC
CAAAAGATGAGGCTGTGGGTGCGCTCCATCTCATCCAAGCTGCGAAACTTGGCAATGCGAAGGCCCAGAGCATCCTAAGAACAGGGCTAT
TGAGTGGCCAGACTTCCCCAACAAATGCCAAATTGGAGAAACTGGACTCTCAGCAGGTGTTGCAGCTCTGCCTCCGATATCAAGATCACC
TGCATCAGTGTGCAGAGGCCGTTGCTTTTGACCAGAATGCTTTGGTTAAACGAATCAAAGAGATGGATCTGTCTGTAGAAACTCTGTTCA
GCTTCATGCAGGAGCGCCAGAAAAGATACGCCAAGTATGCCGAGCAGATCCAGAAAGTGAACGAGATGTCCGCCATCCTCCGCCGCATAC
AGATGGGCATCGACCAGACTGTGCCCCTGCTGGACAGGCTCAACAGCATGCTGCCCGAGGGCGAGCGGCTGGAGCCCTTCAGCATGAAGC
CCGACCGCGAGCTCAGGCTGTAGCTGCTGCCCGGCCTGCCTGGGGCTGGGAGCCCCAGACACCGACACCCTGAGGACGTGTGGAGCTAAG
GTCATATCATCTGACCAGGTCTGGAGGCTGGCGGGAGGCTCCCTGAAAGTGGGTGCGAAGGAGTCCGGCTGGCATGAAAATCTGACTTTG
CCCAGCTCTTTTCCTTGATGCAGTTTCCCGGTGTGGAAGGAACCTAACCAGTTCTCGGTGATAACTGAAGCTGGAACGTGTGAATTATTA
GGAATTCTTTGAAGAACTCTGCATTGAGAATTATTTTTATTTAGTTTTTTTTTTTTTTTAATTGAGAGTATATAGTCCAGTCCAGGTACC
GGAATAAAAATATGGAGACAAGGGGAAAATATTTTACGAAGCTCTGTGTTCTCAACGCCCTCATGAACTTTTCAGTAGGCTGTCTGGTTT
ATGTGTGGTCAACTTGAAAAACTAATTGAATCTAGGTCTCTGTATTGTTCCTGTTTCTACCCTGACTGTTTCCGTCACACCAAGCCCTTA
TCTGGGGCGCGTCTTCCTGCCCAGGTGGAACACTGGCATTTTGTTGACTGTCAGGTTAGGTGTCCCTTAGTCGTCATCAGAAGCTGAAGC
CTTCCTTTCCACACCCTCATCAGATTCATCTCCACTGATAACCGGTTTCCTTGATGCAGACATAGTTTAGCTTTCTTTGACTGCAGAGAT
GTCTCATTCCACAGACATTTCTTGAACCCATTTGATGTGTCCAATATTGTGCCAGGGATACAAATATGGCCGTATAGCCTCAGGCCTTCA
TTTCTGAAAAGAAAAAAGCTCAAAAAGCTGCTGAATTTCTCTGGGAGTTTAGGAAAGGAAGTTATTTGAGTAACAACAAAAGTGCTTAGT
GTCGTACTTTACACATCATAGGTGTTCTAATGGAAGCAAGGACTGGAGAAGCAAAGAGTGGAATGTGAGGAGCAGACCTAGGCAGACACC
TTGAGACTAAAAGTCAGAGCTGAAGGGAGTCGCTGGGGCCAGGACGGCATGCAGGCCTGTACCCTGTTCCCTAAGTTCCTGCAAGCGTCG

>33727_33727_8_GNE-LOH12CR1_GNE_chr9_36218179_ENST00000539815_LOH12CR1_chr12_12588561_ENST00000314565_length(amino acids)=773AA_BP=644
MEKNGNNRKLRVCVATCNRADYSKLAPIMFGIKTEPEFFELDVVVLGSHLIDDYGNTYRMIEQDDFDINTRLHTIVRGEDEAAMVESVGL
ALVKLPDVLNRLKPDIMIVHGDRFDALALATSAALMNIRILHIEGGEVSGTIDDSIRHAITKLAHYHVCCTRSAEQHLISMCEDHDRILL
AGCPSYDKLLSAKNKDYMSIIRMWLGDDVKSKDYIVALQHPVTTDIKHSIKMFELTLDALISFNKRTLVLFPNIDAGSKEMVRVMRKKGI
EHHPNFRAVKHVPFDQFIQLVAHAGCMIGNSSCGVREVGAFGTPVINLGTRQIGRETGENVLHVRDADTQDKILQALHLQFGKQYPCSKI
YGDGNAVPRILKFLKSIDLQEPLQKKFCFPPVKENISQDIDHILETLSALAVDLGGTNLRVAIVSMKGEIVKKYTQFNPKTYEERINLIL
QMCVEAAAEAVKLNCRILGVGISTGGRVNPREGIVLHSTKLIQEWNSVDLRTPLSDTLHLPVWVDNDGNCAALAERKFGQGKGLENFVTL
ITGTGIGGGIIHQHELIHGSSFCAAELGHLVVSLDGPDCSCGSHGCIEAYASGMALQREAKKLHDEDLLLVEGMSVPKDEAVGALHLIQA
AKLGNAKAQSILRTGLLSGQTSPTNAKLEKLDSQQVLQLCLRYQDHLHQCAEAVAFDQNALVKRIKEMDLSVETLFSFMQERQKRYAKYA

--------------------------------------------------------------
>33727_33727_9_GNE-LOH12CR1_GNE_chr9_36218179_ENST00000539815_LOH12CR1_chr12_12588561_ENST00000542728_length(transcript)=2370nt_BP=1974nt
AACTCTATTTTAAGAACCTCTCAAAACGAAACAAGCAAATCATGGAGAAGAATGGAAATAACCGAAAGCTGCGGGTTTGTGTTGCTACTT
GTAACCGTGCAGATTATTCTAAACTTGCCCCGATCATGTTTGGCATTAAAACCGAACCTGAGTTCTTTGAACTTGATGTTGTGGTACTTG
GCTCTCACCTGATAGATGACTATGGAAATACATATCGAATGATTGAACAAGATGACTTTGACATTAACACCAGGCTACACACAATTGTGA
GGGGAGAAGATGAGGCAGCCATGGTGGAGTCAGTAGGCCTGGCCCTAGTGAAGCTGCCAGATGTCCTTAATCGCCTGAAGCCTGATATCA
TGATTGTTCATGGAGACAGGTTTGATGCCCTGGCTCTGGCCACATCTGCTGCCTTGATGAACATCCGAATCCTTCACATTGAAGGTGGGG
AAGTCAGTGGGACCATTGATGACTCTATCAGACATGCCATAACAAAACTGGCTCATTATCATGTGTGCTGCACCCGCAGTGCAGAGCAGC
ACCTGATATCCATGTGTGAGGACCATGATCGCATCCTTTTGGCAGGCTGCCCTTCCTATGACAAACTTCTCTCAGCCAAGAACAAAGACT
ACATGAGCATCATTCGCATGTGGCTAGGTGATGATGTAAAATCTAAAGATTACATTGTTGCACTACAGCACCCTGTGACCACTGACATTA
AGCATTCCATAAAAATGTTTGAATTAACATTGGATGCACTTATCTCATTTAACAAGCGGACCCTAGTCCTGTTTCCAAATATTGACGCAG
GGAGCAAAGAGATGGTTCGAGTGATGCGGAAGAAGGGCATTGAGCATCATCCCAACTTTCGTGCAGTTAAACACGTCCCATTTGACCAGT
TTATACAGTTGGTTGCCCATGCTGGCTGTATGATTGGGAACAGCAGCTGTGGGGTTCGAGAAGTTGGAGCTTTTGGAACACCTGTGATCA
ACCTGGGAACACGTCAGATTGGAAGAGAAACAGGGGAGAATGTTCTTCATGTCCGGGATGCTGACACCCAAGACAAAATATTGCAAGCAC
TGCACCTTCAGTTTGGTAAACAGTACCCTTGTTCAAAGATATATGGGGATGGAAATGCTGTTCCAAGGATTTTGAAGTTTCTCAAATCTA
TCGATCTTCAAGAGCCACTGCAAAAGAAATTCTGCTTTCCTCCTGTGAAGGAGAATATCTCTCAAGATATTGACCATATTCTTGAAACTC
TAAGTGCCTTGGCCGTTGATCTTGGCGGGACGAACCTCCGAGTTGCAATAGTCAGCATGAAGGGTGAAATAGTTAAGAAGTATACTCAGT
TCAATCCTAAAACCTATGAAGAGAGGATTAATTTAATCCTACAGATGTGTGTGGAAGCTGCAGCAGAAGCTGTAAAACTGAACTGCAGAA
TTTTGGGAGTAGGCATTTCCACAGGTGGCCGTGTAAATCCTCGGGAAGGAATTGTGCTGCATTCAACCAAACTGATCCAAGAGTGGAACT
CTGTGGACCTTAGGACCCCCCTTTCTGACACTTTGCATCTCCCTGTGTGGGTAGACAATGATGGCAACTGTGCTGCCCTGGCGGAAAGGA
AATTTGGCCAAGGAAAGGGACTGGAAAACTTTGTTACACTTATCACAGGCACAGGAATCGGTGGTGGAATTATCCATCAGCATGAATTGA
TCCACGGAAGCTCCTTCTGTGCTGCAGAACTGGGCCACCTTGTTGTGTCTCTGGATGGGCCTGATTGTTCCTGTGGAAGCCATGGGTGCA
TTGAAGCATACGCCTCTGGAATGGCCTTGCAGAGGGAGGCAAAAAAGCTCCATGATGAGGACCTGCTCTTGGTGGAAGGGATGTCAGTGC
CAAAAGATGAGGCTGTGGGTGCGCTCCATCTCATCCAAGCTGCGAAACTTGGCAATGCGAAGGCCCAGAGCATCCTAAGAACAGGGCTAT
TGAGTGGCCAGACTTCCCCAACAAATGCCAAATTGGAGAAACTGGACTCTCAGCAGGTGTTGCAGCTCTGCCTCCGATATCAAGATCACC
TGCATCAGTGTGCAGAGGCCGTTGCTTTTGACCAGAATGCTTTGGTTAAACGAATCAAAGAGATGGATCTGTCTGTAGAAACTCTGTTCA
GCTTCATGCAGGAGCGCCAGAAAAGATACGCCAAGTATGCCGAGCAGATCCAGAAAGTGAACGAGATGTCCGCCATCCTCCGCCGCATAC
AGATGGGCATCGACCAGACTGTGCCCCTGCTGGACAGGCTCAACAGCATGCTGCCCGAGGGCGAGCGGCTGGAGCCCTTCAGCATGAAGC

>33727_33727_9_GNE-LOH12CR1_GNE_chr9_36218179_ENST00000539815_LOH12CR1_chr12_12588561_ENST00000542728_length(amino acids)=773AA_BP=644
MEKNGNNRKLRVCVATCNRADYSKLAPIMFGIKTEPEFFELDVVVLGSHLIDDYGNTYRMIEQDDFDINTRLHTIVRGEDEAAMVESVGL
ALVKLPDVLNRLKPDIMIVHGDRFDALALATSAALMNIRILHIEGGEVSGTIDDSIRHAITKLAHYHVCCTRSAEQHLISMCEDHDRILL
AGCPSYDKLLSAKNKDYMSIIRMWLGDDVKSKDYIVALQHPVTTDIKHSIKMFELTLDALISFNKRTLVLFPNIDAGSKEMVRVMRKKGI
EHHPNFRAVKHVPFDQFIQLVAHAGCMIGNSSCGVREVGAFGTPVINLGTRQIGRETGENVLHVRDADTQDKILQALHLQFGKQYPCSKI
YGDGNAVPRILKFLKSIDLQEPLQKKFCFPPVKENISQDIDHILETLSALAVDLGGTNLRVAIVSMKGEIVKKYTQFNPKTYEERINLIL
QMCVEAAAEAVKLNCRILGVGISTGGRVNPREGIVLHSTKLIQEWNSVDLRTPLSDTLHLPVWVDNDGNCAALAERKFGQGKGLENFVTL
ITGTGIGGGIIHQHELIHGSSFCAAELGHLVVSLDGPDCSCGSHGCIEAYASGMALQREAKKLHDEDLLLVEGMSVPKDEAVGALHLIQA
AKLGNAKAQSILRTGLLSGQTSPTNAKLEKLDSQQVLQLCLRYQDHLHQCAEAVAFDQNALVKRIKEMDLSVETLFSFMQERQKRYAKYA

--------------------------------------------------------------
>33727_33727_10_GNE-LOH12CR1_GNE_chr9_36218179_ENST00000543356_LOH12CR1_chr12_12588561_ENST00000298571_length(transcript)=2375nt_BP=1918nt
ATGCCTATTGGTGACTGCTCCGTGGCAGCTAAACCAAGAAAACAGCTGCTCTGCTCATTATTTCAAACCACACTAGGGTACAGAGCTCGT
GCTTCGGGATGGAAACCTATGGTTATCTGCAGAGGGAGTCATGCTTTCAAGGACCTCATAAATACATATCGAATGATTGAACAAGATGAC
TTTGACATTAACACCAGGCTACACACAATTGTGAGGGGAGAAGATGAGGCAGCCATGGTGGAGTCAGTAGGCCTGGCCCTAGTGAAGCTG
CCAGATGTCCTTAATCGCCTGAAGCCTGATATCATGATTGTTCATGGAGACAGGTTTGATGCCCTGGCTCTGGCCACATCTGCTGCCTTG
ATGAACATCCGAATCCTTCACATTGAAGGTGGGGAAGTCAGTGGGACCATTGATGACTCTATCAGACATGCCATAACAAAACTGGCTCAT
TATCATGTGTGCTGCACCCGCAGTGCAGAGCAGCACCTGATATCCATGTGTGAGGACCATGATCGCATCCTTTTGGCAGGCTGCCCTTCC
TATGACAAACTTCTCTCAGCCAAGAACAAAGACTACATGAGCATCATTCGCATGTGGCTAGGTGATGATGTAAAATCTAAAGATTACATT
GTTGCACTACAGCACCCTGTGACCACTGACATTAAGCATTCCATAAAAATGTTTGAATTAACATTGGATGCACTTATCTCATTTAACAAG
CGGACCCTAGTCCTGTTTCCAAATATTGACGCAGGGAGCAAAGAGATGGTTCGAGTGATGCGGAAGAAGGGCATTGAGCATCATCCCAAC
TTTCGTGCAGTTAAACACGTCCCATTTGACCAGTTTATACAGTTGGTTGCCCATGCTGGCTGTATGATTGGGAACAGCAGCTGTGGGGTT
CGAGAAGTTGGAGCTTTTGGAACACCTGTGATCAACCTGGGAACACGTCAGATTGGAAGAGAAACAGGGGAGAATGTTCTTCATGTCCGG
GATGCTGACACCCAAGACAAAATATTGCAAGCACTGCACCTTCAGTTTGGTAAACAGTACCCTTGTTCAAAGATATATGGGGATGGAAAT
GCTGTTCCAAGGATTTTGAAGTTTCTCAAATCTATCGATCTTCAAGAGCCACTGCAAAAGAAATTCTGCTTTCCTCCTGTGAAGGAGAAT
ATCTCTCAAGATATTGACCATATTCTTGAAACTCTAAGTGCCTTGGCCGTTGATCTTGGCGGGACGAACCTCCGAGTTGCAATAGTCAGC
ATGAAGGGTGAAATAGTTAAGAAGTATACTCAGTTCAATCCTAAAACCTATGAAGAGAGGATTAATTTAATCCTACAGATGTGTGTGGAA
GCTGCAGCAGAAGCTGTAAAACTGAACTGCAGAATTTTGGGAGTAGGCATTTCCACAGGTGGCCGTGTAAATCCTCGGGAAGGAATTGTG
CTGCATTCAACCAAACTGATCCAAGAGTGGAACTCTGTGGACCTTAGGACCCCCCTTTCTGACACTTTGCATCTCCCTGTGTGGGTAGAC
AATGATGGCAACTGTGCTGCCCTGGCGGAAAGGAAATTTGGCCAAGGAAAGGGACTGGAAAACTTTGTTACACTTATCACAGGCACAGGA
ATCGGTGGTGGAATTATCCATCAGCATGAATTGATCCACGGAAGCTCCTTCTGTGCTGCAGAACTGGGCCACCTTGTTGTGTCTCTGGAT
GGGCCTGATTGTTCCTGTGGAAGCCATGGGTGCATTGAAGCATACGCCTCTGGAATGGCCTTGCAGAGGGAGGCAAAAAAGCTCCATGAT
GAGGACCTGCTCTTGGTGGAAGGGATGTCAGTGCCAAAAGATGAGGCTGTGGGTGCGCTCCATCTCATCCAAGCTGCGAAACTTGGCAAT
GCGAAGGCCCAGAGCATCCTAAGAACAGGGCTATTGAGTGGCCAGACTTCCCCAACAAATGCCAAATTGGAGAAACTGGACTCTCAGCAG
GTGTTGCAGCTCTGCCTCCGATATCAAGATCACCTGCATCAGTGTGCAGAGGCCGTTGCTTTTGACCAGAATGCTTTGGTTAAACGAATC
AAAGAGATGGATCTGTCTGTAGAAACTCTGTTCAGCTTCATGCAGGAGCGCCAGAAAAGATACGCCAAGTATGCCGAGCAGATCCAGAAA
GTGAACGAGATGTCCGCCATCCTCCGCCGCATACAGATGGGCATCGACCAGACTGTGCCCCTGCTGGACAGGCTCAACAGCATGCTGCCC
GAGGGCGAGCGGCTGGAGCCCTTCAGCATGAAGCCCGACCGCGAGCTCAGGCTGTAGCTGCTGCCCGGCCTGCCTGGGGCTGGGAGCCCC

>33727_33727_10_GNE-LOH12CR1_GNE_chr9_36218179_ENST00000543356_LOH12CR1_chr12_12588561_ENST00000298571_length(amino acids)=768AA_BP=639
MPIGDCSVAAKPRKQLLCSLFQTTLGYRARASGWKPMVICRGSHAFKDLINTYRMIEQDDFDINTRLHTIVRGEDEAAMVESVGLALVKL
PDVLNRLKPDIMIVHGDRFDALALATSAALMNIRILHIEGGEVSGTIDDSIRHAITKLAHYHVCCTRSAEQHLISMCEDHDRILLAGCPS
YDKLLSAKNKDYMSIIRMWLGDDVKSKDYIVALQHPVTTDIKHSIKMFELTLDALISFNKRTLVLFPNIDAGSKEMVRVMRKKGIEHHPN
FRAVKHVPFDQFIQLVAHAGCMIGNSSCGVREVGAFGTPVINLGTRQIGRETGENVLHVRDADTQDKILQALHLQFGKQYPCSKIYGDGN
AVPRILKFLKSIDLQEPLQKKFCFPPVKENISQDIDHILETLSALAVDLGGTNLRVAIVSMKGEIVKKYTQFNPKTYEERINLILQMCVE
AAAEAVKLNCRILGVGISTGGRVNPREGIVLHSTKLIQEWNSVDLRTPLSDTLHLPVWVDNDGNCAALAERKFGQGKGLENFVTLITGTG
IGGGIIHQHELIHGSSFCAAELGHLVVSLDGPDCSCGSHGCIEAYASGMALQREAKKLHDEDLLLVEGMSVPKDEAVGALHLIQAAKLGN
AKAQSILRTGLLSGQTSPTNAKLEKLDSQQVLQLCLRYQDHLHQCAEAVAFDQNALVKRIKEMDLSVETLFSFMQERQKRYAKYAEQIQK

--------------------------------------------------------------
>33727_33727_11_GNE-LOH12CR1_GNE_chr9_36218179_ENST00000543356_LOH12CR1_chr12_12588561_ENST00000314565_length(transcript)=3437nt_BP=1918nt
ATGCCTATTGGTGACTGCTCCGTGGCAGCTAAACCAAGAAAACAGCTGCTCTGCTCATTATTTCAAACCACACTAGGGTACAGAGCTCGT
GCTTCGGGATGGAAACCTATGGTTATCTGCAGAGGGAGTCATGCTTTCAAGGACCTCATAAATACATATCGAATGATTGAACAAGATGAC
TTTGACATTAACACCAGGCTACACACAATTGTGAGGGGAGAAGATGAGGCAGCCATGGTGGAGTCAGTAGGCCTGGCCCTAGTGAAGCTG
CCAGATGTCCTTAATCGCCTGAAGCCTGATATCATGATTGTTCATGGAGACAGGTTTGATGCCCTGGCTCTGGCCACATCTGCTGCCTTG
ATGAACATCCGAATCCTTCACATTGAAGGTGGGGAAGTCAGTGGGACCATTGATGACTCTATCAGACATGCCATAACAAAACTGGCTCAT
TATCATGTGTGCTGCACCCGCAGTGCAGAGCAGCACCTGATATCCATGTGTGAGGACCATGATCGCATCCTTTTGGCAGGCTGCCCTTCC
TATGACAAACTTCTCTCAGCCAAGAACAAAGACTACATGAGCATCATTCGCATGTGGCTAGGTGATGATGTAAAATCTAAAGATTACATT
GTTGCACTACAGCACCCTGTGACCACTGACATTAAGCATTCCATAAAAATGTTTGAATTAACATTGGATGCACTTATCTCATTTAACAAG
CGGACCCTAGTCCTGTTTCCAAATATTGACGCAGGGAGCAAAGAGATGGTTCGAGTGATGCGGAAGAAGGGCATTGAGCATCATCCCAAC
TTTCGTGCAGTTAAACACGTCCCATTTGACCAGTTTATACAGTTGGTTGCCCATGCTGGCTGTATGATTGGGAACAGCAGCTGTGGGGTT
CGAGAAGTTGGAGCTTTTGGAACACCTGTGATCAACCTGGGAACACGTCAGATTGGAAGAGAAACAGGGGAGAATGTTCTTCATGTCCGG
GATGCTGACACCCAAGACAAAATATTGCAAGCACTGCACCTTCAGTTTGGTAAACAGTACCCTTGTTCAAAGATATATGGGGATGGAAAT
GCTGTTCCAAGGATTTTGAAGTTTCTCAAATCTATCGATCTTCAAGAGCCACTGCAAAAGAAATTCTGCTTTCCTCCTGTGAAGGAGAAT
ATCTCTCAAGATATTGACCATATTCTTGAAACTCTAAGTGCCTTGGCCGTTGATCTTGGCGGGACGAACCTCCGAGTTGCAATAGTCAGC
ATGAAGGGTGAAATAGTTAAGAAGTATACTCAGTTCAATCCTAAAACCTATGAAGAGAGGATTAATTTAATCCTACAGATGTGTGTGGAA
GCTGCAGCAGAAGCTGTAAAACTGAACTGCAGAATTTTGGGAGTAGGCATTTCCACAGGTGGCCGTGTAAATCCTCGGGAAGGAATTGTG
CTGCATTCAACCAAACTGATCCAAGAGTGGAACTCTGTGGACCTTAGGACCCCCCTTTCTGACACTTTGCATCTCCCTGTGTGGGTAGAC
AATGATGGCAACTGTGCTGCCCTGGCGGAAAGGAAATTTGGCCAAGGAAAGGGACTGGAAAACTTTGTTACACTTATCACAGGCACAGGA
ATCGGTGGTGGAATTATCCATCAGCATGAATTGATCCACGGAAGCTCCTTCTGTGCTGCAGAACTGGGCCACCTTGTTGTGTCTCTGGAT
GGGCCTGATTGTTCCTGTGGAAGCCATGGGTGCATTGAAGCATACGCCTCTGGAATGGCCTTGCAGAGGGAGGCAAAAAAGCTCCATGAT
GAGGACCTGCTCTTGGTGGAAGGGATGTCAGTGCCAAAAGATGAGGCTGTGGGTGCGCTCCATCTCATCCAAGCTGCGAAACTTGGCAAT
GCGAAGGCCCAGAGCATCCTAAGAACAGGGCTATTGAGTGGCCAGACTTCCCCAACAAATGCCAAATTGGAGAAACTGGACTCTCAGCAG
GTGTTGCAGCTCTGCCTCCGATATCAAGATCACCTGCATCAGTGTGCAGAGGCCGTTGCTTTTGACCAGAATGCTTTGGTTAAACGAATC
AAAGAGATGGATCTGTCTGTAGAAACTCTGTTCAGCTTCATGCAGGAGCGCCAGAAAAGATACGCCAAGTATGCCGAGCAGATCCAGAAA
GTGAACGAGATGTCCGCCATCCTCCGCCGCATACAGATGGGCATCGACCAGACTGTGCCCCTGCTGGACAGGCTCAACAGCATGCTGCCC
GAGGGCGAGCGGCTGGAGCCCTTCAGCATGAAGCCCGACCGCGAGCTCAGGCTGTAGCTGCTGCCCGGCCTGCCTGGGGCTGGGAGCCCC
AGACACCGACACCCTGAGGACGTGTGGAGCTAAGGTCATATCATCTGACCAGGTCTGGAGGCTGGCGGGAGGCTCCCTGAAAGTGGGTGC
GAAGGAGTCCGGCTGGCATGAAAATCTGACTTTGCCCAGCTCTTTTCCTTGATGCAGTTTCCCGGTGTGGAAGGAACCTAACCAGTTCTC
GGTGATAACTGAAGCTGGAACGTGTGAATTATTAGGAATTCTTTGAAGAACTCTGCATTGAGAATTATTTTTATTTAGTTTTTTTTTTTT
TTTAATTGAGAGTATATAGTCCAGTCCAGGTACCGGAATAAAAATATGGAGACAAGGGGAAAATATTTTACGAAGCTCTGTGTTCTCAAC
GCCCTCATGAACTTTTCAGTAGGCTGTCTGGTTTATGTGTGGTCAACTTGAAAAACTAATTGAATCTAGGTCTCTGTATTGTTCCTGTTT
CTACCCTGACTGTTTCCGTCACACCAAGCCCTTATCTGGGGCGCGTCTTCCTGCCCAGGTGGAACACTGGCATTTTGTTGACTGTCAGGT
TAGGTGTCCCTTAGTCGTCATCAGAAGCTGAAGCCTTCCTTTCCACACCCTCATCAGATTCATCTCCACTGATAACCGGTTTCCTTGATG
CAGACATAGTTTAGCTTTCTTTGACTGCAGAGATGTCTCATTCCACAGACATTTCTTGAACCCATTTGATGTGTCCAATATTGTGCCAGG
GATACAAATATGGCCGTATAGCCTCAGGCCTTCATTTCTGAAAAGAAAAAAGCTCAAAAAGCTGCTGAATTTCTCTGGGAGTTTAGGAAA
GGAAGTTATTTGAGTAACAACAAAAGTGCTTAGTGTCGTACTTTACACATCATAGGTGTTCTAATGGAAGCAAGGACTGGAGAAGCAAAG
AGTGGAATGTGAGGAGCAGACCTAGGCAGACACCTTGAGACTAAAAGTCAGAGCTGAAGGGAGTCGCTGGGGCCAGGACGGCATGCAGGC
CTGTACCCTGTTCCCTAAGTTCCTGCAAGCGTCGGGAGGTGTGTTTTCAGATACCAGAAAGAGCCTTCAGTAGATTCACAAGATTAAAAT

>33727_33727_11_GNE-LOH12CR1_GNE_chr9_36218179_ENST00000543356_LOH12CR1_chr12_12588561_ENST00000314565_length(amino acids)=768AA_BP=639
MPIGDCSVAAKPRKQLLCSLFQTTLGYRARASGWKPMVICRGSHAFKDLINTYRMIEQDDFDINTRLHTIVRGEDEAAMVESVGLALVKL
PDVLNRLKPDIMIVHGDRFDALALATSAALMNIRILHIEGGEVSGTIDDSIRHAITKLAHYHVCCTRSAEQHLISMCEDHDRILLAGCPS
YDKLLSAKNKDYMSIIRMWLGDDVKSKDYIVALQHPVTTDIKHSIKMFELTLDALISFNKRTLVLFPNIDAGSKEMVRVMRKKGIEHHPN
FRAVKHVPFDQFIQLVAHAGCMIGNSSCGVREVGAFGTPVINLGTRQIGRETGENVLHVRDADTQDKILQALHLQFGKQYPCSKIYGDGN
AVPRILKFLKSIDLQEPLQKKFCFPPVKENISQDIDHILETLSALAVDLGGTNLRVAIVSMKGEIVKKYTQFNPKTYEERINLILQMCVE
AAAEAVKLNCRILGVGISTGGRVNPREGIVLHSTKLIQEWNSVDLRTPLSDTLHLPVWVDNDGNCAALAERKFGQGKGLENFVTLITGTG
IGGGIIHQHELIHGSSFCAAELGHLVVSLDGPDCSCGSHGCIEAYASGMALQREAKKLHDEDLLLVEGMSVPKDEAVGALHLIQAAKLGN
AKAQSILRTGLLSGQTSPTNAKLEKLDSQQVLQLCLRYQDHLHQCAEAVAFDQNALVKRIKEMDLSVETLFSFMQERQKRYAKYAEQIQK

--------------------------------------------------------------
>33727_33727_12_GNE-LOH12CR1_GNE_chr9_36218179_ENST00000543356_LOH12CR1_chr12_12588561_ENST00000542728_length(transcript)=2314nt_BP=1918nt
ATGCCTATTGGTGACTGCTCCGTGGCAGCTAAACCAAGAAAACAGCTGCTCTGCTCATTATTTCAAACCACACTAGGGTACAGAGCTCGT
GCTTCGGGATGGAAACCTATGGTTATCTGCAGAGGGAGTCATGCTTTCAAGGACCTCATAAATACATATCGAATGATTGAACAAGATGAC
TTTGACATTAACACCAGGCTACACACAATTGTGAGGGGAGAAGATGAGGCAGCCATGGTGGAGTCAGTAGGCCTGGCCCTAGTGAAGCTG
CCAGATGTCCTTAATCGCCTGAAGCCTGATATCATGATTGTTCATGGAGACAGGTTTGATGCCCTGGCTCTGGCCACATCTGCTGCCTTG
ATGAACATCCGAATCCTTCACATTGAAGGTGGGGAAGTCAGTGGGACCATTGATGACTCTATCAGACATGCCATAACAAAACTGGCTCAT
TATCATGTGTGCTGCACCCGCAGTGCAGAGCAGCACCTGATATCCATGTGTGAGGACCATGATCGCATCCTTTTGGCAGGCTGCCCTTCC
TATGACAAACTTCTCTCAGCCAAGAACAAAGACTACATGAGCATCATTCGCATGTGGCTAGGTGATGATGTAAAATCTAAAGATTACATT
GTTGCACTACAGCACCCTGTGACCACTGACATTAAGCATTCCATAAAAATGTTTGAATTAACATTGGATGCACTTATCTCATTTAACAAG
CGGACCCTAGTCCTGTTTCCAAATATTGACGCAGGGAGCAAAGAGATGGTTCGAGTGATGCGGAAGAAGGGCATTGAGCATCATCCCAAC
TTTCGTGCAGTTAAACACGTCCCATTTGACCAGTTTATACAGTTGGTTGCCCATGCTGGCTGTATGATTGGGAACAGCAGCTGTGGGGTT
CGAGAAGTTGGAGCTTTTGGAACACCTGTGATCAACCTGGGAACACGTCAGATTGGAAGAGAAACAGGGGAGAATGTTCTTCATGTCCGG
GATGCTGACACCCAAGACAAAATATTGCAAGCACTGCACCTTCAGTTTGGTAAACAGTACCCTTGTTCAAAGATATATGGGGATGGAAAT
GCTGTTCCAAGGATTTTGAAGTTTCTCAAATCTATCGATCTTCAAGAGCCACTGCAAAAGAAATTCTGCTTTCCTCCTGTGAAGGAGAAT
ATCTCTCAAGATATTGACCATATTCTTGAAACTCTAAGTGCCTTGGCCGTTGATCTTGGCGGGACGAACCTCCGAGTTGCAATAGTCAGC
ATGAAGGGTGAAATAGTTAAGAAGTATACTCAGTTCAATCCTAAAACCTATGAAGAGAGGATTAATTTAATCCTACAGATGTGTGTGGAA
GCTGCAGCAGAAGCTGTAAAACTGAACTGCAGAATTTTGGGAGTAGGCATTTCCACAGGTGGCCGTGTAAATCCTCGGGAAGGAATTGTG
CTGCATTCAACCAAACTGATCCAAGAGTGGAACTCTGTGGACCTTAGGACCCCCCTTTCTGACACTTTGCATCTCCCTGTGTGGGTAGAC
AATGATGGCAACTGTGCTGCCCTGGCGGAAAGGAAATTTGGCCAAGGAAAGGGACTGGAAAACTTTGTTACACTTATCACAGGCACAGGA
ATCGGTGGTGGAATTATCCATCAGCATGAATTGATCCACGGAAGCTCCTTCTGTGCTGCAGAACTGGGCCACCTTGTTGTGTCTCTGGAT
GGGCCTGATTGTTCCTGTGGAAGCCATGGGTGCATTGAAGCATACGCCTCTGGAATGGCCTTGCAGAGGGAGGCAAAAAAGCTCCATGAT
GAGGACCTGCTCTTGGTGGAAGGGATGTCAGTGCCAAAAGATGAGGCTGTGGGTGCGCTCCATCTCATCCAAGCTGCGAAACTTGGCAAT
GCGAAGGCCCAGAGCATCCTAAGAACAGGGCTATTGAGTGGCCAGACTTCCCCAACAAATGCCAAATTGGAGAAACTGGACTCTCAGCAG
GTGTTGCAGCTCTGCCTCCGATATCAAGATCACCTGCATCAGTGTGCAGAGGCCGTTGCTTTTGACCAGAATGCTTTGGTTAAACGAATC
AAAGAGATGGATCTGTCTGTAGAAACTCTGTTCAGCTTCATGCAGGAGCGCCAGAAAAGATACGCCAAGTATGCCGAGCAGATCCAGAAA
GTGAACGAGATGTCCGCCATCCTCCGCCGCATACAGATGGGCATCGACCAGACTGTGCCCCTGCTGGACAGGCTCAACAGCATGCTGCCC

>33727_33727_12_GNE-LOH12CR1_GNE_chr9_36218179_ENST00000543356_LOH12CR1_chr12_12588561_ENST00000542728_length(amino acids)=768AA_BP=639
MPIGDCSVAAKPRKQLLCSLFQTTLGYRARASGWKPMVICRGSHAFKDLINTYRMIEQDDFDINTRLHTIVRGEDEAAMVESVGLALVKL
PDVLNRLKPDIMIVHGDRFDALALATSAALMNIRILHIEGGEVSGTIDDSIRHAITKLAHYHVCCTRSAEQHLISMCEDHDRILLAGCPS
YDKLLSAKNKDYMSIIRMWLGDDVKSKDYIVALQHPVTTDIKHSIKMFELTLDALISFNKRTLVLFPNIDAGSKEMVRVMRKKGIEHHPN
FRAVKHVPFDQFIQLVAHAGCMIGNSSCGVREVGAFGTPVINLGTRQIGRETGENVLHVRDADTQDKILQALHLQFGKQYPCSKIYGDGN
AVPRILKFLKSIDLQEPLQKKFCFPPVKENISQDIDHILETLSALAVDLGGTNLRVAIVSMKGEIVKKYTQFNPKTYEERINLILQMCVE
AAAEAVKLNCRILGVGISTGGRVNPREGIVLHSTKLIQEWNSVDLRTPLSDTLHLPVWVDNDGNCAALAERKFGQGKGLENFVTLITGTG
IGGGIIHQHELIHGSSFCAAELGHLVVSLDGPDCSCGSHGCIEAYASGMALQREAKKLHDEDLLLVEGMSVPKDEAVGALHLIQAAKLGN
AKAQSILRTGLLSGQTSPTNAKLEKLDSQQVLQLCLRYQDHLHQCAEAVAFDQNALVKRIKEMDLSVETLFSFMQERQKRYAKYAEQIQK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GNE-LOH12CR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GNE-LOH12CR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GNE-LOH12CR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource