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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GNPTAB-CCDC53 (FusionGDB2 ID:33819)

Fusion Gene Summary for GNPTAB-CCDC53

Fusion gene summary

Fusion gene information	Fusion gene name: GNPTAB-CCDC53
	Fusion gene ID: 33819
		Hgene	Tgene
	Gene symbol	GNPTAB	CCDC53
	Gene ID	79158	51019
	Gene name	N-acetylglucosamine-1-phosphate transferase subunits alpha and beta	WASH complex subunit 3
	Synonyms	GNPTA\|ICD	CCDC53\|CGI-116
	Cytomap	12q23.2	12q23.2
	Type of gene	protein-coding	protein-coding
	Description	N-acetylglucosamine-1-phosphotransferase subunits alpha/betaGlcNAc phosphotransferaseN-acetylglucosamine-1-phosphate transferase alpha and beta subunitsUDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/betaUDP-N-acetylglucosamine-lysosomal-e	WASH complex subunit 3WASH complex subunit CCDC53coiled-coil domain containing 53coiled-coil domain-containing protein 53
	Modification date	20200328	20200327
	UniProtAcc	Q3T906	.
	Ensembl transtripts involved in fusion gene	ENST00000299314, ENST00000392919, ENST00000549165, ENST00000549940,	ENST00000539515, ENST00000240079, ENST00000545679,
Fusion gene scores	* DoF score	12 X 9 X 7=756	6 X 3 X 6=108
	# samples	12	6
	** MAII score	log2(12/756*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GNPTAB [Title/Abstract] AND CCDC53 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GNPTAB(102224337)-CCDC53(102439897), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GNPTAB	GO:0046835	carbohydrate phosphorylation	19955174\|23733939

Fusion gene breakpoints across GNPTAB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CCDC53 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-14-0817-01A	GNPTAB	chr12	102224337	-	CCDC53	chr12	102439897	-

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Fusion Gene ORF analysis for GNPTAB-CCDC53

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000299314	ENST00000539515	GNPTAB	chr12	102224337	-	CCDC53	chr12	102439897	-
5CDS-5UTR	ENST00000392919	ENST00000539515	GNPTAB	chr12	102224337	-	CCDC53	chr12	102439897	-
5CDS-5UTR	ENST00000549165	ENST00000539515	GNPTAB	chr12	102224337	-	CCDC53	chr12	102439897	-
5CDS-5UTR	ENST00000549940	ENST00000539515	GNPTAB	chr12	102224337	-	CCDC53	chr12	102439897	-
In-frame	ENST00000299314	ENST00000240079	GNPTAB	chr12	102224337	-	CCDC53	chr12	102439897	-
In-frame	ENST00000299314	ENST00000545679	GNPTAB	chr12	102224337	-	CCDC53	chr12	102439897	-
In-frame	ENST00000392919	ENST00000240079	GNPTAB	chr12	102224337	-	CCDC53	chr12	102439897	-
In-frame	ENST00000392919	ENST00000545679	GNPTAB	chr12	102224337	-	CCDC53	chr12	102439897	-
In-frame	ENST00000549165	ENST00000240079	GNPTAB	chr12	102224337	-	CCDC53	chr12	102439897	-
In-frame	ENST00000549165	ENST00000545679	GNPTAB	chr12	102224337	-	CCDC53	chr12	102439897	-
In-frame	ENST00000549940	ENST00000240079	GNPTAB	chr12	102224337	-	CCDC53	chr12	102439897	-
In-frame	ENST00000549940	ENST00000545679	GNPTAB	chr12	102224337	-	CCDC53	chr12	102439897	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000299314	GNPTAB	chr12	102224337	-	ENST00000240079	CCDC53	chr12	102439897	-	984	380	155	814	219
ENST00000299314	GNPTAB	chr12	102224337	-	ENST00000545679	CCDC53	chr12	102439897	-	978	380	155	811	218
ENST00000549940	GNPTAB	chr12	102224337	-	ENST00000240079	CCDC53	chr12	102439897	-	864	260	35	694	219
ENST00000549940	GNPTAB	chr12	102224337	-	ENST00000545679	CCDC53	chr12	102439897	-	858	260	35	691	218
ENST00000392919	GNPTAB	chr12	102224337	-	ENST00000240079	CCDC53	chr12	102439897	-	889	285	60	719	219
ENST00000392919	GNPTAB	chr12	102224337	-	ENST00000545679	CCDC53	chr12	102439897	-	883	285	60	716	218
ENST00000549165	GNPTAB	chr12	102224337	-	ENST00000240079	CCDC53	chr12	102439897	-	725	121	4	555	183
ENST00000549165	GNPTAB	chr12	102224337	-	ENST00000545679	CCDC53	chr12	102439897	-	719	121	4	552	182

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000299314	ENST00000240079	GNPTAB	chr12	102224337	-	CCDC53	chr12	102439897	-	0.002503816	0.9974962
ENST00000299314	ENST00000545679	GNPTAB	chr12	102224337	-	CCDC53	chr12	102439897	-	0.00240309	0.9975969
ENST00000549940	ENST00000240079	GNPTAB	chr12	102224337	-	CCDC53	chr12	102439897	-	0.003034467	0.9969656
ENST00000549940	ENST00000545679	GNPTAB	chr12	102224337	-	CCDC53	chr12	102439897	-	0.002868378	0.9971316
ENST00000392919	ENST00000240079	GNPTAB	chr12	102224337	-	CCDC53	chr12	102439897	-	0.002698113	0.9973018
ENST00000392919	ENST00000545679	GNPTAB	chr12	102224337	-	CCDC53	chr12	102439897	-	0.002592752	0.99740726
ENST00000549165	ENST00000240079	GNPTAB	chr12	102224337	-	CCDC53	chr12	102439897	-	0.002335389	0.9976646
ENST00000549165	ENST00000545679	GNPTAB	chr12	102224337	-	CCDC53	chr12	102439897	-	0.002214238	0.9977857

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Fusion Genomic Features for GNPTAB-CCDC53

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GNPTAB-CCDC53

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:102224337/chr12:102439897)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GNPTAB Q3T906	.
FUNCTION: Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment. {ECO:0000269\|PubMed:19955174, ECO:0000269\|PubMed:23733939, ECO:0000269\|PubMed:28918368}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GNPTAB

chr12:102224337

chr12:102439897

ENST00000299314

22_42

1257.0

Transmembrane

Helical

Hgene

GNPTAB

chr12:102224337

chr12:102439897

ENST00000549940

22_42

491.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GNPTAB

chr12:102224337

chr12:102439897

ENST00000299314

1018_1029

1257.0

Calcium binding

Ontology_term=ECO:0000255

Hgene

GNPTAB

chr12:102224337

chr12:102439897

ENST00000549940

1018_1029

491.0

Calcium binding

Ontology_term=ECO:0000255

Hgene

GNPTAB

chr12:102224337

chr12:102439897

ENST00000299314

465_498

1257.0

Compositional bias

Note=Gly-rich

Hgene

GNPTAB

chr12:102224337

chr12:102439897

ENST00000549940

465_498

491.0

Compositional bias

Note=Gly-rich

Hgene

GNPTAB

chr12:102224337

chr12:102439897

ENST00000299314

1005_1040

1257.0

Domain

EF-hand

Hgene

GNPTAB

chr12:102224337

chr12:102439897

ENST00000299314

699_798

1257.0

Domain

DMAP1-binding

Hgene

GNPTAB

chr12:102224337

chr12:102439897

ENST00000549940

1005_1040

491.0

Domain

EF-hand

Hgene

GNPTAB

chr12:102224337

chr12:102439897

ENST00000549940

699_798

491.0

Domain

DMAP1-binding

Hgene

GNPTAB

chr12:102224337

chr12:102439897

ENST00000299314

438_473

1257.0

Repeat

Note=LNR 1

Hgene

GNPTAB

chr12:102224337

chr12:102439897

ENST00000299314

505_545

1257.0

Repeat

Note=LNR 2

Hgene

GNPTAB

chr12:102224337

chr12:102439897

ENST00000549940

438_473

491.0

Repeat

Note=LNR 1

Hgene

GNPTAB

chr12:102224337

chr12:102439897

ENST00000549940

505_545

491.0

Repeat

Note=LNR 2

Hgene

GNPTAB

chr12:102224337

chr12:102439897

ENST00000299314

1215_1235

1257.0

Transmembrane

Helical

Hgene

GNPTAB

chr12:102224337

chr12:102439897

ENST00000549940

1215_1235

491.0

Transmembrane

Helical

Tgene

CCDC53

chr12:102224337

chr12:102439897

ENST00000240079

46_74

195.0

Coiled coil

Ontology_term=ECO:0000255

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Fusion Gene Sequence for GNPTAB-CCDC53

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>33819_33819_1_GNPTAB-CCDC53_GNPTAB_chr12_102224337_ENST00000299314_CCDC53_chr12_102439897_ENST00000240079_length(transcript)=984nt_BP=380nt
AGACCCGGGCGGCGCCGGCCGCCTCGCCGGCCGCAGGTCCGCCTCCGCCGCGCCGAGGGCGTGGGCTCCCGGCTCCCGGAAGCGGCGGCC
GCGGCGCGGAGCCGAGCGGGCGTCCGTCGCCGGAGCTGCAATGAGCGGCGCCCGGAGGCTGTGACCTGCGCGCGGCGGCCCGACCGGGGC
CCCTGAATGGCGGCTCGCTGAGGCGGCGGCGGCGGCGGCGGCGGCTCAGGCTCCTCGGGGCGTGGCGTGGCGGTGAAGGGGTGATGCTGT
TCAAGCTCCTGCAGAGACAGACCTATACCTGCCTGTCCCACAGGTATGGGCTCTACGTGTGCTTCTTGGGCGTCGTTGTCACCATCGTCT
CCGCCTTCCAGTTCGGAGAGAAACTGGCAGACCTTTCACTTCGTATCCAACAAATTGAAACAACTCTCAATATTTTAGATGCAAAGTTGT
CATCTATCCCAGGCCTAGATGATGTCACAGTTGAAGTATCTCCTTTAAATGTCACCAGTGTCACAAATGGAGCACATCCTGAAGCCACTT
CAGAGCAACCACAGCAGAACAGTACACAAGACTCTGGACTACAGGAAAGTGAAGTATCAGCAGAAAATATCTTAACTGTAGCCAAGGATC
CAAGATATGCCAGATATCTCAAAATGGTTCAAGTGGGTGTACCAGTGATGGCAATAAGAAACAAAATGATATCAGAAGGACTAGACCCAG
ATCTTCTTGAGAGGCCAGATGCTCCAGTGCCTGATGGCGAAAGTGAGAAAACTGTAGAAGAAAGTTCAGATAGCGAATCTTCTTTTAGTG
ATTAAGCTTAATTTTGATAAGAATTACATATGCATGCATAGGGGTACATTTACATTCTGTAAGAGATTGAGCCTGAACTCTCTTAGTCAT

>33819_33819_1_GNPTAB-CCDC53_GNPTAB_chr12_102224337_ENST00000299314_CCDC53_chr12_102439897_ENST00000240079_length(amino acids)=219AA_BP=75
MRAAARPGPLNGGSLRRRRRRRRLRLLGAWRGGEGVMLFKLLQRQTYTCLSHRYGLYVCFLGVVVTIVSAFQFGEKLADLSLRIQQIETT
LNILDAKLSSIPGLDDVTVEVSPLNVTSVTNGAHPEATSEQPQQNSTQDSGLQESEVSAENILTVAKDPRYARYLKMVQVGVPVMAIRNK

--------------------------------------------------------------
>33819_33819_2_GNPTAB-CCDC53_GNPTAB_chr12_102224337_ENST00000299314_CCDC53_chr12_102439897_ENST00000545679_length(transcript)=978nt_BP=380nt
AGACCCGGGCGGCGCCGGCCGCCTCGCCGGCCGCAGGTCCGCCTCCGCCGCGCCGAGGGCGTGGGCTCCCGGCTCCCGGAAGCGGCGGCC
GCGGCGCGGAGCCGAGCGGGCGTCCGTCGCCGGAGCTGCAATGAGCGGCGCCCGGAGGCTGTGACCTGCGCGCGGCGGCCCGACCGGGGC
CCCTGAATGGCGGCTCGCTGAGGCGGCGGCGGCGGCGGCGGCGGCTCAGGCTCCTCGGGGCGTGGCGTGGCGGTGAAGGGGTGATGCTGT
TCAAGCTCCTGCAGAGACAGACCTATACCTGCCTGTCCCACAGGTATGGGCTCTACGTGTGCTTCTTGGGCGTCGTTGTCACCATCGTCT
CCGCCTTCCAGTTCGGAGAGAAACTGGCAGACCTTTCACTTCGTATCCAACAAATTGAAACAACTCTCAATATTTTAGATGCAAAGTTGT
CATCTATCCCAGGCCTAGATGATGTCACAGTTGAAGTATCTCCTTTAAATGTCACCAGTGTCACAAATGGAGCACATCCTGAAGCCACTT
CAGAGCAACCACAGAACAGTACACAAGACTCTGGACTACAGGAAAGTGAAGTATCAGCAGAAAATATCTTAACTGTAGCCAAGGATCCAA
GATATGCCAGATATCTCAAAATGGTTCAAGTGGGTGTACCAGTGATGGCAATAAGAAACAAAATGATATCAGAAGGACTAGACCCAGATC
TTCTTGAGAGGCCAGATGCTCCAGTGCCTGATGGCGAAAGTGAGAAAACTGTAGAAGAAAGTTCAGATAGCGAATCTTCTTTTAGTGATT
AAGCTTAATTTTGATAAGAATTACATATGCATGCATAGGGGTACATTTACATTCTGTAAGAGATTGAGCCTGAACTCTCTTAGTCATAAA

>33819_33819_2_GNPTAB-CCDC53_GNPTAB_chr12_102224337_ENST00000299314_CCDC53_chr12_102439897_ENST00000545679_length(amino acids)=218AA_BP=75
MRAAARPGPLNGGSLRRRRRRRRLRLLGAWRGGEGVMLFKLLQRQTYTCLSHRYGLYVCFLGVVVTIVSAFQFGEKLADLSLRIQQIETT
LNILDAKLSSIPGLDDVTVEVSPLNVTSVTNGAHPEATSEQPQNSTQDSGLQESEVSAENILTVAKDPRYARYLKMVQVGVPVMAIRNKM

--------------------------------------------------------------
>33819_33819_3_GNPTAB-CCDC53_GNPTAB_chr12_102224337_ENST00000392919_CCDC53_chr12_102439897_ENST00000240079_length(transcript)=889nt_BP=285nt
GCGGAGCCGAGCGGGCGTCCGTCGCCGGAGCTGCAATGAGCGGCGCCCGGAGGCTGTGACCTGCGCGCGGCGGCCCGACCGGGGCCCCTG
AATGGCGGCTCGCTGAGGCGGCGGCGGCGGCGGCGGCGGCTCAGGCTCCTCGGGGCGTGGCGTGGCGGTGAAGGGGTGATGCTGTTCAAG
CTCCTGCAGAGACAGACCTATACCTGCCTGTCCCACAGGTATGGGCTCTACGTGTGCTTCTTGGGCGTCGTTGTCACCATCGTCTCCGCC
TTCCAGTTCGGAGAGAAACTGGCAGACCTTTCACTTCGTATCCAACAAATTGAAACAACTCTCAATATTTTAGATGCAAAGTTGTCATCT
ATCCCAGGCCTAGATGATGTCACAGTTGAAGTATCTCCTTTAAATGTCACCAGTGTCACAAATGGAGCACATCCTGAAGCCACTTCAGAG
CAACCACAGCAGAACAGTACACAAGACTCTGGACTACAGGAAAGTGAAGTATCAGCAGAAAATATCTTAACTGTAGCCAAGGATCCAAGA
TATGCCAGATATCTCAAAATGGTTCAAGTGGGTGTACCAGTGATGGCAATAAGAAACAAAATGATATCAGAAGGACTAGACCCAGATCTT
CTTGAGAGGCCAGATGCTCCAGTGCCTGATGGCGAAAGTGAGAAAACTGTAGAAGAAAGTTCAGATAGCGAATCTTCTTTTAGTGATTAA
GCTTAATTTTGATAAGAATTACATATGCATGCATAGGGGTACATTTACATTCTGTAAGAGATTGAGCCTGAACTCTCTTAGTCATAAAAA

>33819_33819_3_GNPTAB-CCDC53_GNPTAB_chr12_102224337_ENST00000392919_CCDC53_chr12_102439897_ENST00000240079_length(amino acids)=219AA_BP=75
MRAAARPGPLNGGSLRRRRRRRRLRLLGAWRGGEGVMLFKLLQRQTYTCLSHRYGLYVCFLGVVVTIVSAFQFGEKLADLSLRIQQIETT
LNILDAKLSSIPGLDDVTVEVSPLNVTSVTNGAHPEATSEQPQQNSTQDSGLQESEVSAENILTVAKDPRYARYLKMVQVGVPVMAIRNK

--------------------------------------------------------------
>33819_33819_4_GNPTAB-CCDC53_GNPTAB_chr12_102224337_ENST00000392919_CCDC53_chr12_102439897_ENST00000545679_length(transcript)=883nt_BP=285nt
GCGGAGCCGAGCGGGCGTCCGTCGCCGGAGCTGCAATGAGCGGCGCCCGGAGGCTGTGACCTGCGCGCGGCGGCCCGACCGGGGCCCCTG
AATGGCGGCTCGCTGAGGCGGCGGCGGCGGCGGCGGCGGCTCAGGCTCCTCGGGGCGTGGCGTGGCGGTGAAGGGGTGATGCTGTTCAAG
CTCCTGCAGAGACAGACCTATACCTGCCTGTCCCACAGGTATGGGCTCTACGTGTGCTTCTTGGGCGTCGTTGTCACCATCGTCTCCGCC
TTCCAGTTCGGAGAGAAACTGGCAGACCTTTCACTTCGTATCCAACAAATTGAAACAACTCTCAATATTTTAGATGCAAAGTTGTCATCT
ATCCCAGGCCTAGATGATGTCACAGTTGAAGTATCTCCTTTAAATGTCACCAGTGTCACAAATGGAGCACATCCTGAAGCCACTTCAGAG
CAACCACAGAACAGTACACAAGACTCTGGACTACAGGAAAGTGAAGTATCAGCAGAAAATATCTTAACTGTAGCCAAGGATCCAAGATAT
GCCAGATATCTCAAAATGGTTCAAGTGGGTGTACCAGTGATGGCAATAAGAAACAAAATGATATCAGAAGGACTAGACCCAGATCTTCTT
GAGAGGCCAGATGCTCCAGTGCCTGATGGCGAAAGTGAGAAAACTGTAGAAGAAAGTTCAGATAGCGAATCTTCTTTTAGTGATTAAGCT
TAATTTTGATAAGAATTACATATGCATGCATAGGGGTACATTTACATTCTGTAAGAGATTGAGCCTGAACTCTCTTAGTCATAAAAACAT

>33819_33819_4_GNPTAB-CCDC53_GNPTAB_chr12_102224337_ENST00000392919_CCDC53_chr12_102439897_ENST00000545679_length(amino acids)=218AA_BP=75
MRAAARPGPLNGGSLRRRRRRRRLRLLGAWRGGEGVMLFKLLQRQTYTCLSHRYGLYVCFLGVVVTIVSAFQFGEKLADLSLRIQQIETT
LNILDAKLSSIPGLDDVTVEVSPLNVTSVTNGAHPEATSEQPQNSTQDSGLQESEVSAENILTVAKDPRYARYLKMVQVGVPVMAIRNKM

--------------------------------------------------------------
>33819_33819_5_GNPTAB-CCDC53_GNPTAB_chr12_102224337_ENST00000549165_CCDC53_chr12_102439897_ENST00000240079_length(transcript)=725nt_BP=121nt
GGTGATGCTGTTCAAGCTCCTGCAGAGACAGACCTATACCTGCCTGTCCCACAGGTATGGGCTCTACGTGTGCTTCTTGGGCGTCGTTGT
CACCATCGTCTCCGCCTTCCAGTTCGGAGAGAAACTGGCAGACCTTTCACTTCGTATCCAACAAATTGAAACAACTCTCAATATTTTAGA
TGCAAAGTTGTCATCTATCCCAGGCCTAGATGATGTCACAGTTGAAGTATCTCCTTTAAATGTCACCAGTGTCACAAATGGAGCACATCC
TGAAGCCACTTCAGAGCAACCACAGCAGAACAGTACACAAGACTCTGGACTACAGGAAAGTGAAGTATCAGCAGAAAATATCTTAACTGT
AGCCAAGGATCCAAGATATGCCAGATATCTCAAAATGGTTCAAGTGGGTGTACCAGTGATGGCAATAAGAAACAAAATGATATCAGAAGG
ACTAGACCCAGATCTTCTTGAGAGGCCAGATGCTCCAGTGCCTGATGGCGAAAGTGAGAAAACTGTAGAAGAAAGTTCAGATAGCGAATC
TTCTTTTAGTGATTAAGCTTAATTTTGATAAGAATTACATATGCATGCATAGGGGTACATTTACATTCTGTAAGAGATTGAGCCTGAACT
CTCTTAGTCATAAAAACATCAAATGGCCACATGTCCACTACCAAGCTTCTTCTATGTTAAAAAAATAATAATAAAGCAGTTTTAACCTGC

>33819_33819_5_GNPTAB-CCDC53_GNPTAB_chr12_102224337_ENST00000549165_CCDC53_chr12_102439897_ENST00000240079_length(amino acids)=183AA_BP=39
MLFKLLQRQTYTCLSHRYGLYVCFLGVVVTIVSAFQFGEKLADLSLRIQQIETTLNILDAKLSSIPGLDDVTVEVSPLNVTSVTNGAHPE
ATSEQPQQNSTQDSGLQESEVSAENILTVAKDPRYARYLKMVQVGVPVMAIRNKMISEGLDPDLLERPDAPVPDGESEKTVEESSDSESS

--------------------------------------------------------------
>33819_33819_6_GNPTAB-CCDC53_GNPTAB_chr12_102224337_ENST00000549165_CCDC53_chr12_102439897_ENST00000545679_length(transcript)=719nt_BP=121nt
GGTGATGCTGTTCAAGCTCCTGCAGAGACAGACCTATACCTGCCTGTCCCACAGGTATGGGCTCTACGTGTGCTTCTTGGGCGTCGTTGT
CACCATCGTCTCCGCCTTCCAGTTCGGAGAGAAACTGGCAGACCTTTCACTTCGTATCCAACAAATTGAAACAACTCTCAATATTTTAGA
TGCAAAGTTGTCATCTATCCCAGGCCTAGATGATGTCACAGTTGAAGTATCTCCTTTAAATGTCACCAGTGTCACAAATGGAGCACATCC
TGAAGCCACTTCAGAGCAACCACAGAACAGTACACAAGACTCTGGACTACAGGAAAGTGAAGTATCAGCAGAAAATATCTTAACTGTAGC
CAAGGATCCAAGATATGCCAGATATCTCAAAATGGTTCAAGTGGGTGTACCAGTGATGGCAATAAGAAACAAAATGATATCAGAAGGACT
AGACCCAGATCTTCTTGAGAGGCCAGATGCTCCAGTGCCTGATGGCGAAAGTGAGAAAACTGTAGAAGAAAGTTCAGATAGCGAATCTTC
TTTTAGTGATTAAGCTTAATTTTGATAAGAATTACATATGCATGCATAGGGGTACATTTACATTCTGTAAGAGATTGAGCCTGAACTCTC

>33819_33819_6_GNPTAB-CCDC53_GNPTAB_chr12_102224337_ENST00000549165_CCDC53_chr12_102439897_ENST00000545679_length(amino acids)=182AA_BP=39
MLFKLLQRQTYTCLSHRYGLYVCFLGVVVTIVSAFQFGEKLADLSLRIQQIETTLNILDAKLSSIPGLDDVTVEVSPLNVTSVTNGAHPE
ATSEQPQNSTQDSGLQESEVSAENILTVAKDPRYARYLKMVQVGVPVMAIRNKMISEGLDPDLLERPDAPVPDGESEKTVEESSDSESSF

--------------------------------------------------------------
>33819_33819_7_GNPTAB-CCDC53_GNPTAB_chr12_102224337_ENST00000549940_CCDC53_chr12_102439897_ENST00000240079_length(transcript)=864nt_BP=260nt
CGGAGCTGCAATGAGCGGCGCCCGGAGGCTGTGACCTGCGCGCGGCGGCCCGACCGGGGCCCCTGAATGGCGGCTCGCTGAGGCGGCGGC
GGCGGCGGCGGCGGCTCAGGCTCCTCGGGGCGTGGCGTGGCGGTGAAGGGGTGATGCTGTTCAAGCTCCTGCAGAGACAGACCTATACCT
GCCTGTCCCACAGGTATGGGCTCTACGTGTGCTTCTTGGGCGTCGTTGTCACCATCGTCTCCGCCTTCCAGTTCGGAGAGAAACTGGCAG
ACCTTTCACTTCGTATCCAACAAATTGAAACAACTCTCAATATTTTAGATGCAAAGTTGTCATCTATCCCAGGCCTAGATGATGTCACAG
TTGAAGTATCTCCTTTAAATGTCACCAGTGTCACAAATGGAGCACATCCTGAAGCCACTTCAGAGCAACCACAGCAGAACAGTACACAAG
ACTCTGGACTACAGGAAAGTGAAGTATCAGCAGAAAATATCTTAACTGTAGCCAAGGATCCAAGATATGCCAGATATCTCAAAATGGTTC
AAGTGGGTGTACCAGTGATGGCAATAAGAAACAAAATGATATCAGAAGGACTAGACCCAGATCTTCTTGAGAGGCCAGATGCTCCAGTGC
CTGATGGCGAAAGTGAGAAAACTGTAGAAGAAAGTTCAGATAGCGAATCTTCTTTTAGTGATTAAGCTTAATTTTGATAAGAATTACATA
TGCATGCATAGGGGTACATTTACATTCTGTAAGAGATTGAGCCTGAACTCTCTTAGTCATAAAAACATCAAATGGCCACATGTCCACTAC

>33819_33819_7_GNPTAB-CCDC53_GNPTAB_chr12_102224337_ENST00000549940_CCDC53_chr12_102439897_ENST00000240079_length(amino acids)=219AA_BP=75
MRAAARPGPLNGGSLRRRRRRRRLRLLGAWRGGEGVMLFKLLQRQTYTCLSHRYGLYVCFLGVVVTIVSAFQFGEKLADLSLRIQQIETT
LNILDAKLSSIPGLDDVTVEVSPLNVTSVTNGAHPEATSEQPQQNSTQDSGLQESEVSAENILTVAKDPRYARYLKMVQVGVPVMAIRNK

--------------------------------------------------------------
>33819_33819_8_GNPTAB-CCDC53_GNPTAB_chr12_102224337_ENST00000549940_CCDC53_chr12_102439897_ENST00000545679_length(transcript)=858nt_BP=260nt
CGGAGCTGCAATGAGCGGCGCCCGGAGGCTGTGACCTGCGCGCGGCGGCCCGACCGGGGCCCCTGAATGGCGGCTCGCTGAGGCGGCGGC
GGCGGCGGCGGCGGCTCAGGCTCCTCGGGGCGTGGCGTGGCGGTGAAGGGGTGATGCTGTTCAAGCTCCTGCAGAGACAGACCTATACCT
GCCTGTCCCACAGGTATGGGCTCTACGTGTGCTTCTTGGGCGTCGTTGTCACCATCGTCTCCGCCTTCCAGTTCGGAGAGAAACTGGCAG
ACCTTTCACTTCGTATCCAACAAATTGAAACAACTCTCAATATTTTAGATGCAAAGTTGTCATCTATCCCAGGCCTAGATGATGTCACAG
TTGAAGTATCTCCTTTAAATGTCACCAGTGTCACAAATGGAGCACATCCTGAAGCCACTTCAGAGCAACCACAGAACAGTACACAAGACT
CTGGACTACAGGAAAGTGAAGTATCAGCAGAAAATATCTTAACTGTAGCCAAGGATCCAAGATATGCCAGATATCTCAAAATGGTTCAAG
TGGGTGTACCAGTGATGGCAATAAGAAACAAAATGATATCAGAAGGACTAGACCCAGATCTTCTTGAGAGGCCAGATGCTCCAGTGCCTG
ATGGCGAAAGTGAGAAAACTGTAGAAGAAAGTTCAGATAGCGAATCTTCTTTTAGTGATTAAGCTTAATTTTGATAAGAATTACATATGC
ATGCATAGGGGTACATTTACATTCTGTAAGAGATTGAGCCTGAACTCTCTTAGTCATAAAAACATCAAATGGCCACATGTCCACTACCAA

>33819_33819_8_GNPTAB-CCDC53_GNPTAB_chr12_102224337_ENST00000549940_CCDC53_chr12_102439897_ENST00000545679_length(amino acids)=218AA_BP=75
MRAAARPGPLNGGSLRRRRRRRRLRLLGAWRGGEGVMLFKLLQRQTYTCLSHRYGLYVCFLGVVVTIVSAFQFGEKLADLSLRIQQIETT
LNILDAKLSSIPGLDDVTVEVSPLNVTSVTNGAHPEATSEQPQNSTQDSGLQESEVSAENILTVAKDPRYARYLKMVQVGVPVMAIRNKM

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for GNPTAB-CCDC53

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GNPTAB-CCDC53

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for GNPTAB-CCDC53

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source