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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GNS-RAB3IP (FusionGDB2 ID:33851)

Fusion Gene Summary for GNS-RAB3IP

check button Fusion gene summary
Fusion gene informationFusion gene name: GNS-RAB3IP
Fusion gene ID: 33851
HgeneTgene
Gene symbol

GNS

RAB3IP

Gene ID

2799

117177

Gene nameglucosamine (N-acetyl)-6-sulfataseRAB3A interacting protein
SynonymsG6SRABIN3|RABIN8
Cytomap

12q14.3

12q15

Type of geneprotein-codingprotein-coding
DescriptionN-acetylglucosamine-6-sulfataseglucosamine -6-sulfataserab-3A-interacting proteinSSX2 interacting proteinrab3A-interacting proteinrabin-3
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000258145, ENST00000418919, 
ENST00000542058, ENST00000543646, 
ENST00000325555, ENST00000362025, 
ENST00000378815, ENST00000483530, 
ENST00000550536, ENST00000550847, 
ENST00000551641, ENST00000553099, 
ENST00000247833, 
Fusion gene scores* DoF score12 X 11 X 7=92420 X 17 X 10=3400
# samples 1329
** MAII scorelog2(13/924*10)=-2.8293812283876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(29/3400*10)=-3.55140994101013
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GNS [Title/Abstract] AND RAB3IP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGNS(65138589)-RAB3IP(70206744), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRAB3IP

GO:0006612

protein targeting to membrane

23382462


check buttonFusion gene breakpoints across GNS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RAB3IP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-GN-A26D-06AGNSchr12

65138589

-RAB3IPchr12

70206744

+


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Fusion Gene ORF analysis for GNS-RAB3IP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000258145ENST00000325555GNSchr12

65138589

-RAB3IPchr12

70206744

+
5CDS-intronENST00000258145ENST00000362025GNSchr12

65138589

-RAB3IPchr12

70206744

+
5CDS-intronENST00000258145ENST00000378815GNSchr12

65138589

-RAB3IPchr12

70206744

+
5CDS-intronENST00000258145ENST00000483530GNSchr12

65138589

-RAB3IPchr12

70206744

+
5CDS-intronENST00000258145ENST00000550536GNSchr12

65138589

-RAB3IPchr12

70206744

+
5CDS-intronENST00000258145ENST00000550847GNSchr12

65138589

-RAB3IPchr12

70206744

+
5CDS-intronENST00000258145ENST00000551641GNSchr12

65138589

-RAB3IPchr12

70206744

+
5CDS-intronENST00000258145ENST00000553099GNSchr12

65138589

-RAB3IPchr12

70206744

+
5CDS-intronENST00000418919ENST00000325555GNSchr12

65138589

-RAB3IPchr12

70206744

+
5CDS-intronENST00000418919ENST00000362025GNSchr12

65138589

-RAB3IPchr12

70206744

+
5CDS-intronENST00000418919ENST00000378815GNSchr12

65138589

-RAB3IPchr12

70206744

+
5CDS-intronENST00000418919ENST00000483530GNSchr12

65138589

-RAB3IPchr12

70206744

+
5CDS-intronENST00000418919ENST00000550536GNSchr12

65138589

-RAB3IPchr12

70206744

+
5CDS-intronENST00000418919ENST00000550847GNSchr12

65138589

-RAB3IPchr12

70206744

+
5CDS-intronENST00000418919ENST00000551641GNSchr12

65138589

-RAB3IPchr12

70206744

+
5CDS-intronENST00000418919ENST00000553099GNSchr12

65138589

-RAB3IPchr12

70206744

+
5CDS-intronENST00000542058ENST00000325555GNSchr12

65138589

-RAB3IPchr12

70206744

+
5CDS-intronENST00000542058ENST00000362025GNSchr12

65138589

-RAB3IPchr12

70206744

+
5CDS-intronENST00000542058ENST00000378815GNSchr12

65138589

-RAB3IPchr12

70206744

+
5CDS-intronENST00000542058ENST00000483530GNSchr12

65138589

-RAB3IPchr12

70206744

+
5CDS-intronENST00000542058ENST00000550536GNSchr12

65138589

-RAB3IPchr12

70206744

+
5CDS-intronENST00000542058ENST00000550847GNSchr12

65138589

-RAB3IPchr12

70206744

+
5CDS-intronENST00000542058ENST00000551641GNSchr12

65138589

-RAB3IPchr12

70206744

+
5CDS-intronENST00000542058ENST00000553099GNSchr12

65138589

-RAB3IPchr12

70206744

+
5CDS-intronENST00000543646ENST00000325555GNSchr12

65138589

-RAB3IPchr12

70206744

+
5CDS-intronENST00000543646ENST00000362025GNSchr12

65138589

-RAB3IPchr12

70206744

+
5CDS-intronENST00000543646ENST00000378815GNSchr12

65138589

-RAB3IPchr12

70206744

+
5CDS-intronENST00000543646ENST00000483530GNSchr12

65138589

-RAB3IPchr12

70206744

+
5CDS-intronENST00000543646ENST00000550536GNSchr12

65138589

-RAB3IPchr12

70206744

+
5CDS-intronENST00000543646ENST00000550847GNSchr12

65138589

-RAB3IPchr12

70206744

+
5CDS-intronENST00000543646ENST00000551641GNSchr12

65138589

-RAB3IPchr12

70206744

+
5CDS-intronENST00000543646ENST00000553099GNSchr12

65138589

-RAB3IPchr12

70206744

+
In-frameENST00000258145ENST00000247833GNSchr12

65138589

-RAB3IPchr12

70206744

+
In-frameENST00000418919ENST00000247833GNSchr12

65138589

-RAB3IPchr12

70206744

+
In-frameENST00000542058ENST00000247833GNSchr12

65138589

-RAB3IPchr12

70206744

+
In-frameENST00000543646ENST00000247833GNSchr12

65138589

-RAB3IPchr12

70206744

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000418919GNSchr1265138589-ENST00000247833RAB3IPchr1270206744+263054651698215
ENST00000258145GNSchr1265138589-ENST00000247833RAB3IPchr1270206744+28797953947314
ENST00000543646GNSchr1265138589-ENST00000247833RAB3IPchr1270206744+2934850491002317
ENST00000542058GNSchr1265138589-ENST00000247833RAB3IPchr1270206744+280371974871265

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000418919ENST00000247833GNSchr1265138589-RAB3IPchr1270206744+0.0007859020.99921405
ENST00000258145ENST00000247833GNSchr1265138589-RAB3IPchr1270206744+0.0018793750.9981206
ENST00000543646ENST00000247833GNSchr1265138589-RAB3IPchr1270206744+0.0008693140.99913067
ENST00000542058ENST00000247833GNSchr1265138589-RAB3IPchr1270206744+0.0021174860.99788254

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Fusion Genomic Features for GNS-RAB3IP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GNSchr1265138588-RAB3IPchr1270206743+0.000614750.99938524
GNSchr1265138588-RAB3IPchr1270206743+0.000614750.99938524

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GNS-RAB3IP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:65138589/chr12:70206744)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for GNS-RAB3IP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>33851_33851_1_GNS-RAB3IP_GNS_chr12_65138589_ENST00000258145_RAB3IP_chr12_70206744_ENST00000247833_length(transcript)=2879nt_BP=795nt
CCCCTGTCCCTGGCTCACGTGATCGCGCCTAGGGAGAAAACGTCTGACTCCAGCCACCGGCCTTCAAGGCACGGCTTTTTATTCCTTCGG
CTGGTCGGCCTCTCGCCCTTCAGCTACCTGTGCGTCCCTCCGTCCCGTCCCGTCCCGGGGTCACCCCGGAGCCTGTCCGCTATGCGGCTC
CTGCCTCTAGCCCCAGGTCGGCTCCGGCGGGGCAGCCCCCGCCACCTGCCCTCCTGCAGCCCAGCGCTGCTACTGCTGGTGCTGGGCGGC
TGCCTGGGGGTCTTCGGGGTGGCTGCGGGAACCCGGAGGCCCAACGTGGTGCTGCTCCTCACGGACGACCAGGACGAAGTGCTCGGCGGC
ATGACACCGCTAAAGAAAACCAAAGCTCTCATCGGAGAGATGGGGATGACTTTTTCCAGTGCTTATGTGCCAAGTGCTCTCTGCTGCCCC
AGCAGAGCCAGTATCCTGACAGGAAAGTACCCACATAATCATCACGTTGTGAACAACACTCTGGAGGGGAACTGCAGTAGTAAGTCCTGG
CAGAAGATCCAAGAACCAAATACTTTCCCAGCAATTCTCAGATCAATGTGTGGTTATCAGACCTTTTTTGCAGGGAAATATTTAAATGAG
TACGGAGCCCCAGATGCAGGTGGACTAGAACACGTTCCTCTGGGTTGGAGTTACTGGTATGCCTTGGAAAAGAATTCTAAGTATTATAAT
TACACCCTGTCTATCAATGGGAAGGCACGGAAGCATGGTGAAAACTATAGTGTGGACTACCTGACAGATGTTTTGATCACTTCTGTATGT
AACTTTTTTACATACATTCGATACATTCAGCAGGGACTCGTGAAACAGCAGGATGTTGATCAGATGTTTTGGGAGGTTATGCAGTTGAGA
AAAGAGATGTCATTGGCAAAGCTGGGTTATTTCAAAGAGGAACTCTGATGCTCTGCGTGGGACCATGCCTGAACTCCCCGAATAACTGAA
AAATGGCTGAATATTTTTATGGTTACTTGATATTTATTTCCAAGGAGTGAGCCTAAGACTTTTTTCCCCTTTTGCAAATTGCTCTAAGAA
GTACCATGATTTCTTTTAAACTGATCTATGCTGTGTTTGCTTATTCTTTAGTTGAACACACTATGAAGAATTCCAGGTGTACTAGTGAAT
GTAATTTATAGTTGCCAAAAAAAAAAAAAACCTGAAATAAATAAATGTTAGATTGAATGTGTGTACATTTTCTCTTCTAGCTCTGACATG
GCATTTAGGGTTAGCAGAATGTATTAAATAGTAATTTTCAAACTACACAGTAGCTTCCTTCCTTGTGAGAGGCAAGAAAGAAGTCTGAGT
GGATAGTACTCACTTTCCAAGGCCCCCACCTCTAGAATGGCTTTATTTTTATCTGTTTTCTATATTGGGTTTCAAAAAAGATTTTATTTG
AAGAAATACTTCTGCTGCTACAAAGTTTGAAAGTTACTATTTTAATTATTCTGCTCTCTGTAACTGAAAGAATCCCTTTATTTTGGTTAT
TCATTAAAATATAATAGAAGGCAGTCAGATTTTATCCCAGAGATGTATTCCTGAGTGTCTTGATATAGTGTATTCATGTTTTATATGTGT
TGACCACTATATTGTCATTGGAGGGACATAGATGTAAATGAGTTTGACGTGTGTCAAAGGGGTTTAAAGGGGTGTGGATTGAATGAATGG
TACGTGCGAAGTATATGCTGATTATAGAACCACTTGATCTCTGCATTCCAAATTGTAAAACTGACTCAACTGGAGAAATTATAACAAAGA
GGTTTGTGGTAGACATGTAATAAGTATAGAAAAGCAAAAAGAAAAGAGAAACTGCTTTAGTTTCTGTTTAGAGAAAGCTGCTGTTAATAT
TTTTGGATAGTAGCCTTTCAGCTTTCAGATATTTTCTACTTACATATGCATATTTTTGAAACAAAAAGTAGGCTTTTTTTTTGCTTTTTA
AACCTAAACATTAAATATATTTTCCCTTGGGTAAACCTACACATCCTAATCCCTGTTTATAGAATTTTAACATAATTTAATTGTGTTTGG
AGATGAGGTGGTTTTCAGTTTATTTTTCATATTATAATGCTGTGACGAGTATCCTTATCTGTACACTTCTGAACATTGTGGAGTTCTTTC
ATGTGGATGCCTGGAGATAAAATTGTGTCGAGATATATATGTATTTTTAAATGTTTGATCTGCATTGCTAGATTGCCATCCAGAAAAGTT
AATCAATTTGTATTCACAGCAGCAGTGTACAAGAGGGCTGGTTTTCTGAAGATAACATTTTTTTCAGTCCTGTTCAGAGGTTTGGTCAAT
CTTACCTGTAGATGACTTCAGCCACCAGGCTGGATGGGAGCCCACAGACAAAAGGACATTGGTGTATGTTATGGTGAAAACCATCAGTAC
CATGCCTAGCTCAAGAATGTGAAATTGAACCTGAAAAAAACTTTGAACCTACAATTTTATGTTCTGAAAATAGTTATTCTAATGTGAGGG
CATTAATAAGAATATGTACCATCAAAGCTTCAGAAGATTTTCCGTACAAACTAAAATCACTTTTGGAGAAAGTACCTAAATAAAAAGAGA
AACAAATCCAGGAGATACTGTACGGTTTGAAAGAAAGGTAATCAAATACTCAGAAAAAGTTTGTTGATGACTTAAAAAGGATAAATAAAA
AGTAAGACTAAAGAAAATCAGTATACCCATTAATAATAAATCTTTAGTAATCTATAAGGGGAAGAATGCTTTTCAACCTTATACACTAGA

>33851_33851_1_GNS-RAB3IP_GNS_chr12_65138589_ENST00000258145_RAB3IP_chr12_70206744_ENST00000247833_length(amino acids)=314AA_BP=264
MSLAHVIAPREKTSDSSHRPSRHGFLFLRLVGLSPFSYLCVPPSRPVPGSPRSLSAMRLLPLAPGRLRRGSPRHLPSCSPALLLLVLGGC
LGVFGVAAGTRRPNVVLLLTDDQDEVLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKSWQ
KIQEPNTFPAILRSMCGYQTFFAGKYLNEYGAPDAGGLEHVPLGWSYWYALEKNSKYYNYTLSINGKARKHGENYSVDYLTDVLITSVCN

--------------------------------------------------------------
>33851_33851_2_GNS-RAB3IP_GNS_chr12_65138589_ENST00000418919_RAB3IP_chr12_70206744_ENST00000247833_length(transcript)=2630nt_BP=546nt
GCTGACCATTTGGGAATAAAAGATTGAGTAAGATGTAACAAAACAGGAATTCTGGGCTGTGTGTCTCAATTTATTGGAAGAAATTGTTTA
ATGGATAATTACTTACTTTTACAGACACCGCTAAAGAAAACCAAAGCTCTCATCGGAGAGATGGGGATGACTTTTTCCAGTGCTTATGTG
CCAAGTGCTCTCTGCTGCCCCAGCAGAGCCAGTATCCTGACAGGAAAGTACCCACATAATCATCACGTTGTGAACAACACTCTGGAGGGG
AACTGCAGTAGTAAGTCCTGGCAGAAGATCCAAGAACCAAATACTTTCCCAGCAATTCTCAGATCAATGTGTGGTTATCAGACCTTTTTT
GCAGGGAAATATTTAAATGAGTACGGAGCCCCAGATGCAGGTGGACTAGAACACGTTCCTCTGGGTTGGAGTTACTGGTATGCCTTGGAA
AAGAATTCTAAGTATTATAATTACACCCTGTCTATCAATGGGAAGGCACGGAAGCATGGTGAAAACTATAGTGTGGACTACCTGACAGAT
GTTTTGATCACTTCTGTATGTAACTTTTTTACATACATTCGATACATTCAGCAGGGACTCGTGAAACAGCAGGATGTTGATCAGATGTTT
TGGGAGGTTATGCAGTTGAGAAAAGAGATGTCATTGGCAAAGCTGGGTTATTTCAAAGAGGAACTCTGATGCTCTGCGTGGGACCATGCC
TGAACTCCCCGAATAACTGAAAAATGGCTGAATATTTTTATGGTTACTTGATATTTATTTCCAAGGAGTGAGCCTAAGACTTTTTTCCCC
TTTTGCAAATTGCTCTAAGAAGTACCATGATTTCTTTTAAACTGATCTATGCTGTGTTTGCTTATTCTTTAGTTGAACACACTATGAAGA
ATTCCAGGTGTACTAGTGAATGTAATTTATAGTTGCCAAAAAAAAAAAAAACCTGAAATAAATAAATGTTAGATTGAATGTGTGTACATT
TTCTCTTCTAGCTCTGACATGGCATTTAGGGTTAGCAGAATGTATTAAATAGTAATTTTCAAACTACACAGTAGCTTCCTTCCTTGTGAG
AGGCAAGAAAGAAGTCTGAGTGGATAGTACTCACTTTCCAAGGCCCCCACCTCTAGAATGGCTTTATTTTTATCTGTTTTCTATATTGGG
TTTCAAAAAAGATTTTATTTGAAGAAATACTTCTGCTGCTACAAAGTTTGAAAGTTACTATTTTAATTATTCTGCTCTCTGTAACTGAAA
GAATCCCTTTATTTTGGTTATTCATTAAAATATAATAGAAGGCAGTCAGATTTTATCCCAGAGATGTATTCCTGAGTGTCTTGATATAGT
GTATTCATGTTTTATATGTGTTGACCACTATATTGTCATTGGAGGGACATAGATGTAAATGAGTTTGACGTGTGTCAAAGGGGTTTAAAG
GGGTGTGGATTGAATGAATGGTACGTGCGAAGTATATGCTGATTATAGAACCACTTGATCTCTGCATTCCAAATTGTAAAACTGACTCAA
CTGGAGAAATTATAACAAAGAGGTTTGTGGTAGACATGTAATAAGTATAGAAAAGCAAAAAGAAAAGAGAAACTGCTTTAGTTTCTGTTT
AGAGAAAGCTGCTGTTAATATTTTTGGATAGTAGCCTTTCAGCTTTCAGATATTTTCTACTTACATATGCATATTTTTGAAACAAAAAGT
AGGCTTTTTTTTTGCTTTTTAAACCTAAACATTAAATATATTTTCCCTTGGGTAAACCTACACATCCTAATCCCTGTTTATAGAATTTTA
ACATAATTTAATTGTGTTTGGAGATGAGGTGGTTTTCAGTTTATTTTTCATATTATAATGCTGTGACGAGTATCCTTATCTGTACACTTC
TGAACATTGTGGAGTTCTTTCATGTGGATGCCTGGAGATAAAATTGTGTCGAGATATATATGTATTTTTAAATGTTTGATCTGCATTGCT
AGATTGCCATCCAGAAAAGTTAATCAATTTGTATTCACAGCAGCAGTGTACAAGAGGGCTGGTTTTCTGAAGATAACATTTTTTTCAGTC
CTGTTCAGAGGTTTGGTCAATCTTACCTGTAGATGACTTCAGCCACCAGGCTGGATGGGAGCCCACAGACAAAAGGACATTGGTGTATGT
TATGGTGAAAACCATCAGTACCATGCCTAGCTCAAGAATGTGAAATTGAACCTGAAAAAAACTTTGAACCTACAATTTTATGTTCTGAAA
ATAGTTATTCTAATGTGAGGGCATTAATAAGAATATGTACCATCAAAGCTTCAGAAGATTTTCCGTACAAACTAAAATCACTTTTGGAGA
AAGTACCTAAATAAAAAGAGAAACAAATCCAGGAGATACTGTACGGTTTGAAAGAAAGGTAATCAAATACTCAGAAAAAGTTTGTTGATG
ACTTAAAAAGGATAAATAAAAAGTAAGACTAAAGAAAATCAGTATACCCATTAATAATAAATCTTTAGTAATCTATAAGGGGAAGAATGC
TTTTCAACCTTATACACTAGAAGCATGCTCTTTAAAATTAATGCAACAGGATGACGACTTGATGTAGAAACTATATGTGGAATTATAGAT

>33851_33851_2_GNS-RAB3IP_GNS_chr12_65138589_ENST00000418919_RAB3IP_chr12_70206744_ENST00000247833_length(amino acids)=215AA_BP=165
MGCVSQFIGRNCLMDNYLLLQTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKSWQKIQEPNTFP
AILRSMCGYQTFFAGKYLNEYGAPDAGGLEHVPLGWSYWYALEKNSKYYNYTLSINGKARKHGENYSVDYLTDVLITSVCNFFTYIRYIQ

--------------------------------------------------------------
>33851_33851_3_GNS-RAB3IP_GNS_chr12_65138589_ENST00000542058_RAB3IP_chr12_70206744_ENST00000247833_length(transcript)=2803nt_BP=719nt
ACGTGATCGCGCCTAGGGAGAAAACGTCTGACTCCAGCCACCGGCCTTCAAGGCACGGCTTTTTATTCCTTCGGCTGGTCGGCCTCTCGC
CCTTCAGCTACCTGTGCGTCCCTCCGTCCCGTCCCGTCCCGGGGTCACCCCGGAGCCTGTCCGCTATGCGGCTCCTGCCTCTAGCCCCAG
GTCGGCTCCGGCGGGGCAGCCCCCGCCACCTGCCCTCCTGCAGCCCAGCGCTGCTACTGCTGGTGCTGGGCGGCTGCCTGGGGGTCTTCG
GGGTGGCTGCGGGAACCCGGAGGCCCAACGTGGTGCTGCTCCTCACGGACGACCAGGACGAAGTGCTCGGCGGCATGTATGTGCCAAGTG
CTCTCTGCTGCCCCAGCAGAGCCAGTATCCTGACAGGAAAGTACCCACATAATCATCACGTTGTGAACAACACTCTGGAGGGGAACTGCA
GTAGTAAGTCCTGGCAGAAGATCCAAGAACCAAATACTTTCCCAGCAATTCTCAGATCAATGTGTGGTTATCAGACCTTTTTTGCAGGGA
AATATTTAAATGAGTACGGAGCCCCAGATGCAGGTGGACTAGAACACGTTCCTCTGGGTTGGAGTTACTGGTATGCCTTGGAAAAGAATT
CTAAGTATTATAATTACACCCTGTCTATCAATGGGAAGGCACGGAAGCATGGTGAAAACTATAGTGTGGACTACCTGACAGATGTTTTGA
TCACTTCTGTATGTAACTTTTTTACATACATTCGATACATTCAGCAGGGACTCGTGAAACAGCAGGATGTTGATCAGATGTTTTGGGAGG
TTATGCAGTTGAGAAAAGAGATGTCATTGGCAAAGCTGGGTTATTTCAAAGAGGAACTCTGATGCTCTGCGTGGGACCATGCCTGAACTC
CCCGAATAACTGAAAAATGGCTGAATATTTTTATGGTTACTTGATATTTATTTCCAAGGAGTGAGCCTAAGACTTTTTTCCCCTTTTGCA
AATTGCTCTAAGAAGTACCATGATTTCTTTTAAACTGATCTATGCTGTGTTTGCTTATTCTTTAGTTGAACACACTATGAAGAATTCCAG
GTGTACTAGTGAATGTAATTTATAGTTGCCAAAAAAAAAAAAAACCTGAAATAAATAAATGTTAGATTGAATGTGTGTACATTTTCTCTT
CTAGCTCTGACATGGCATTTAGGGTTAGCAGAATGTATTAAATAGTAATTTTCAAACTACACAGTAGCTTCCTTCCTTGTGAGAGGCAAG
AAAGAAGTCTGAGTGGATAGTACTCACTTTCCAAGGCCCCCACCTCTAGAATGGCTTTATTTTTATCTGTTTTCTATATTGGGTTTCAAA
AAAGATTTTATTTGAAGAAATACTTCTGCTGCTACAAAGTTTGAAAGTTACTATTTTAATTATTCTGCTCTCTGTAACTGAAAGAATCCC
TTTATTTTGGTTATTCATTAAAATATAATAGAAGGCAGTCAGATTTTATCCCAGAGATGTATTCCTGAGTGTCTTGATATAGTGTATTCA
TGTTTTATATGTGTTGACCACTATATTGTCATTGGAGGGACATAGATGTAAATGAGTTTGACGTGTGTCAAAGGGGTTTAAAGGGGTGTG
GATTGAATGAATGGTACGTGCGAAGTATATGCTGATTATAGAACCACTTGATCTCTGCATTCCAAATTGTAAAACTGACTCAACTGGAGA
AATTATAACAAAGAGGTTTGTGGTAGACATGTAATAAGTATAGAAAAGCAAAAAGAAAAGAGAAACTGCTTTAGTTTCTGTTTAGAGAAA
GCTGCTGTTAATATTTTTGGATAGTAGCCTTTCAGCTTTCAGATATTTTCTACTTACATATGCATATTTTTGAAACAAAAAGTAGGCTTT
TTTTTTGCTTTTTAAACCTAAACATTAAATATATTTTCCCTTGGGTAAACCTACACATCCTAATCCCTGTTTATAGAATTTTAACATAAT
TTAATTGTGTTTGGAGATGAGGTGGTTTTCAGTTTATTTTTCATATTATAATGCTGTGACGAGTATCCTTATCTGTACACTTCTGAACAT
TGTGGAGTTCTTTCATGTGGATGCCTGGAGATAAAATTGTGTCGAGATATATATGTATTTTTAAATGTTTGATCTGCATTGCTAGATTGC
CATCCAGAAAAGTTAATCAATTTGTATTCACAGCAGCAGTGTACAAGAGGGCTGGTTTTCTGAAGATAACATTTTTTTCAGTCCTGTTCA
GAGGTTTGGTCAATCTTACCTGTAGATGACTTCAGCCACCAGGCTGGATGGGAGCCCACAGACAAAAGGACATTGGTGTATGTTATGGTG
AAAACCATCAGTACCATGCCTAGCTCAAGAATGTGAAATTGAACCTGAAAAAAACTTTGAACCTACAATTTTATGTTCTGAAAATAGTTA
TTCTAATGTGAGGGCATTAATAAGAATATGTACCATCAAAGCTTCAGAAGATTTTCCGTACAAACTAAAATCACTTTTGGAGAAAGTACC
TAAATAAAAAGAGAAACAAATCCAGGAGATACTGTACGGTTTGAAAGAAAGGTAATCAAATACTCAGAAAAAGTTTGTTGATGACTTAAA
AAGGATAAATAAAAAGTAAGACTAAAGAAAATCAGTATACCCATTAATAATAAATCTTTAGTAATCTATAAGGGGAAGAATGCTTTTCAA
CCTTATACACTAGAAGCATGCTCTTTAAAATTAATGCAACAGGATGACGACTTGATGTAGAAACTATATGTGGAATTATAGATTAAAATG

>33851_33851_3_GNS-RAB3IP_GNS_chr12_65138589_ENST00000542058_RAB3IP_chr12_70206744_ENST00000247833_length(amino acids)=265AA_BP=215
MVGLSPFSYLCVPPSRPVPGSPRSLSAMRLLPLAPGRLRRGSPRHLPSCSPALLLLVLGGCLGVFGVAAGTRRPNVVLLLTDDQDEVLGG
MYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAGKYLNEYGAPDAGGLEHVPLGWSYWY

--------------------------------------------------------------
>33851_33851_4_GNS-RAB3IP_GNS_chr12_65138589_ENST00000543646_RAB3IP_chr12_70206744_ENST00000247833_length(transcript)=2934nt_BP=850nt
GTCTGACTCCAGCCACCGGCCTTCAAGGCACGGCTTTTTATTCCTTCGGCTGGTCGGCCTCTCGCCCTTCAGCTACCTGTGCGTCCCTCC
GTCCCGTCCCGTCCCGGGGTCACCCCGGAGCCTGTCCGCTATGCGGCTCCTGCCTCTAGCCCCAGGTCGGCTCCGGCGGGGCAGCCCCCG
CCACCTGCCCTCCTGCAGCCCAGCGCTGCTACTGCTGGTGCTGGGCGGCTGCCTGGGGGTCTTCGGGGTGGCTGCGGGAACCCGGAGGCC
CAACGTGGTGCTGCTCCTCACGGACGACCAGGACGAAGTGCTCGGCGGCATGGCTTTTTCAGAATATTCTACCACTAATTGTCAAACAGG
ACTCCAAGGGGAAGAGCTAGGACAAGAGCATTTGAGAACTTACTTGGAGCCGAGCAGAACACCGCTAAAGAAAACCAAAGCTCTCATCGG
AGAGATGGGGATGACTTTTTCCAGTGCTTATGTGCCAAGTGCTCTCTGCTGCCCCAGCAGAGCCAGTATCCTGACAGGAAAGTACCCACA
TAATCATCACGTTGTGAACAACACTCTGGAGGGGAACTGCAGTAGTAAGTCCTGGCAGAAGATCCAAGAACCAAATACTTTCCCAGCAAT
TCTCAGATCAATGTGTGGTTATCAGACCTTTTTTGCAGGGAAATATTTAAATGAGTACGGAGCCCCAGATGCAGGTGGACTAGAACACGT
TCCTCTGGGTTGGAGTTACTGGTATGCCTTGGAAAAGAATTCTAAGTATTATAATTACACCCTGTCTATCAATGGGAAGGCACGGAAGCA
TGGTGAAAACTATAGTGTGGACTACCTGACAGATGTTTTGATCACTTCTGTATGTAACTTTTTTACATACATTCGATACATTCAGCAGGG
ACTCGTGAAACAGCAGGATGTTGATCAGATGTTTTGGGAGGTTATGCAGTTGAGAAAAGAGATGTCATTGGCAAAGCTGGGTTATTTCAA
AGAGGAACTCTGATGCTCTGCGTGGGACCATGCCTGAACTCCCCGAATAACTGAAAAATGGCTGAATATTTTTATGGTTACTTGATATTT
ATTTCCAAGGAGTGAGCCTAAGACTTTTTTCCCCTTTTGCAAATTGCTCTAAGAAGTACCATGATTTCTTTTAAACTGATCTATGCTGTG
TTTGCTTATTCTTTAGTTGAACACACTATGAAGAATTCCAGGTGTACTAGTGAATGTAATTTATAGTTGCCAAAAAAAAAAAAAACCTGA
AATAAATAAATGTTAGATTGAATGTGTGTACATTTTCTCTTCTAGCTCTGACATGGCATTTAGGGTTAGCAGAATGTATTAAATAGTAAT
TTTCAAACTACACAGTAGCTTCCTTCCTTGTGAGAGGCAAGAAAGAAGTCTGAGTGGATAGTACTCACTTTCCAAGGCCCCCACCTCTAG
AATGGCTTTATTTTTATCTGTTTTCTATATTGGGTTTCAAAAAAGATTTTATTTGAAGAAATACTTCTGCTGCTACAAAGTTTGAAAGTT
ACTATTTTAATTATTCTGCTCTCTGTAACTGAAAGAATCCCTTTATTTTGGTTATTCATTAAAATATAATAGAAGGCAGTCAGATTTTAT
CCCAGAGATGTATTCCTGAGTGTCTTGATATAGTGTATTCATGTTTTATATGTGTTGACCACTATATTGTCATTGGAGGGACATAGATGT
AAATGAGTTTGACGTGTGTCAAAGGGGTTTAAAGGGGTGTGGATTGAATGAATGGTACGTGCGAAGTATATGCTGATTATAGAACCACTT
GATCTCTGCATTCCAAATTGTAAAACTGACTCAACTGGAGAAATTATAACAAAGAGGTTTGTGGTAGACATGTAATAAGTATAGAAAAGC
AAAAAGAAAAGAGAAACTGCTTTAGTTTCTGTTTAGAGAAAGCTGCTGTTAATATTTTTGGATAGTAGCCTTTCAGCTTTCAGATATTTT
CTACTTACATATGCATATTTTTGAAACAAAAAGTAGGCTTTTTTTTTGCTTTTTAAACCTAAACATTAAATATATTTTCCCTTGGGTAAA
CCTACACATCCTAATCCCTGTTTATAGAATTTTAACATAATTTAATTGTGTTTGGAGATGAGGTGGTTTTCAGTTTATTTTTCATATTAT
AATGCTGTGACGAGTATCCTTATCTGTACACTTCTGAACATTGTGGAGTTCTTTCATGTGGATGCCTGGAGATAAAATTGTGTCGAGATA
TATATGTATTTTTAAATGTTTGATCTGCATTGCTAGATTGCCATCCAGAAAAGTTAATCAATTTGTATTCACAGCAGCAGTGTACAAGAG
GGCTGGTTTTCTGAAGATAACATTTTTTTCAGTCCTGTTCAGAGGTTTGGTCAATCTTACCTGTAGATGACTTCAGCCACCAGGCTGGAT
GGGAGCCCACAGACAAAAGGACATTGGTGTATGTTATGGTGAAAACCATCAGTACCATGCCTAGCTCAAGAATGTGAAATTGAACCTGAA
AAAAACTTTGAACCTACAATTTTATGTTCTGAAAATAGTTATTCTAATGTGAGGGCATTAATAAGAATATGTACCATCAAAGCTTCAGAA
GATTTTCCGTACAAACTAAAATCACTTTTGGAGAAAGTACCTAAATAAAAAGAGAAACAAATCCAGGAGATACTGTACGGTTTGAAAGAA
AGGTAATCAAATACTCAGAAAAAGTTTGTTGATGACTTAAAAAGGATAAATAAAAAGTAAGACTAAAGAAAATCAGTATACCCATTAATA
ATAAATCTTTAGTAATCTATAAGGGGAAGAATGCTTTTCAACCTTATACACTAGAAGCATGCTCTTTAAAATTAATGCAACAGGATGACG

>33851_33851_4_GNS-RAB3IP_GNS_chr12_65138589_ENST00000543646_RAB3IP_chr12_70206744_ENST00000247833_length(amino acids)=317AA_BP=267
MVGLSPFSYLCVPPSRPVPGSPRSLSAMRLLPLAPGRLRRGSPRHLPSCSPALLLLVLGGCLGVFGVAAGTRRPNVVLLLTDDQDEVLGG
MAFSEYSTTNCQTGLQGEELGQEHLRTYLEPSRTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSK
SWQKIQEPNTFPAILRSMCGYQTFFAGKYLNEYGAPDAGGLEHVPLGWSYWYALEKNSKYYNYTLSINGKARKHGENYSVDYLTDVLITS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GNS-RAB3IP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GNS-RAB3IP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GNS-RAB3IP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource