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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:GOLGA3-POLE (FusionGDB2 ID:33879) |
Fusion Gene Summary for GOLGA3-POLE |
Fusion gene summary |
Fusion gene information | Fusion gene name: GOLGA3-POLE | Fusion gene ID: 33879 | Hgene | Tgene | Gene symbol | GOLGA3 | POLE | Gene ID | 2802 | 5426 |
Gene name | golgin A3 | DNA polymerase epsilon, catalytic subunit | |
Synonyms | GCP170|MEA-2 | CRCS12|FILS|IMAGEI|POLE1 | |
Cytomap | 12q24.33 | 12q24.33 | |
Type of gene | protein-coding | protein-coding | |
Description | golgin subfamily A member 3Golgi membrane associated proteinGolgi peripheral membrane proteinSY2/SY10 proteingolgi autoantigen, golgin subfamily a, 3golgi complex-associated protein of 170 kDagolgin-160golgin-165male enhanced antigen-2 | DNA polymerase epsilon catalytic subunit ADNA polymerase II subunit ADNA polymerase epsilon catalytic subunit proteinpolymerase (DNA directed), epsilon, catalytic subunitpolymerase (DNA) epsilon, catalytic subunit | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000204726, ENST00000450791, ENST00000456883, ENST00000537452, ENST00000545875, ENST00000534967, | ENST00000434528, ENST00000320574, ENST00000535270, | |
Fusion gene scores | * DoF score | 15 X 51 X 17=13005 | 5 X 5 X 5=125 |
# samples | 89 | 6 | |
** MAII score | log2(89/13005*10)=-3.86911725297659 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/125*10)=-1.05889368905357 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: GOLGA3 [Title/Abstract] AND POLE [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | POLE(133248801)-GOLGA3(133360893), # samples:2 GOLGA3(133398582)-POLE(133257865), # samples:1 GOLGA3(133374926)-POLE(133257865), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | GOLGA3-POLE seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. GOLGA3-POLE seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. GOLGA3-POLE seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. GOLGA3-POLE seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. POLE-GOLGA3 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. POLE-GOLGA3 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. POLE-GOLGA3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. POLE-GOLGA3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | POLE | GO:0006287 | base-excision repair, gap-filling | 10559260 |
Fusion gene breakpoints across GOLGA3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across POLE (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BRCA | TCGA-B6-A0RT-01A | GOLGA3 | chr12 | 133398582 | - | POLE | chr12 | 133257865 | - |
ChimerDB4 | COAD | TCGA-AA-3660-01A | GOLGA3 | chr12 | 133374926 | - | POLE | chr12 | 133257865 | - |
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Fusion Gene ORF analysis for GOLGA3-POLE |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000204726 | ENST00000434528 | GOLGA3 | chr12 | 133398582 | - | POLE | chr12 | 133257865 | - |
5CDS-intron | ENST00000204726 | ENST00000434528 | GOLGA3 | chr12 | 133374926 | - | POLE | chr12 | 133257865 | - |
5CDS-intron | ENST00000450791 | ENST00000434528 | GOLGA3 | chr12 | 133398582 | - | POLE | chr12 | 133257865 | - |
5CDS-intron | ENST00000450791 | ENST00000434528 | GOLGA3 | chr12 | 133374926 | - | POLE | chr12 | 133257865 | - |
5CDS-intron | ENST00000456883 | ENST00000434528 | GOLGA3 | chr12 | 133398582 | - | POLE | chr12 | 133257865 | - |
5CDS-intron | ENST00000456883 | ENST00000434528 | GOLGA3 | chr12 | 133374926 | - | POLE | chr12 | 133257865 | - |
5CDS-intron | ENST00000537452 | ENST00000434528 | GOLGA3 | chr12 | 133398582 | - | POLE | chr12 | 133257865 | - |
5CDS-intron | ENST00000537452 | ENST00000434528 | GOLGA3 | chr12 | 133374926 | - | POLE | chr12 | 133257865 | - |
5CDS-intron | ENST00000545875 | ENST00000434528 | GOLGA3 | chr12 | 133398582 | - | POLE | chr12 | 133257865 | - |
5CDS-intron | ENST00000545875 | ENST00000434528 | GOLGA3 | chr12 | 133374926 | - | POLE | chr12 | 133257865 | - |
Frame-shift | ENST00000204726 | ENST00000320574 | GOLGA3 | chr12 | 133398582 | - | POLE | chr12 | 133257865 | - |
Frame-shift | ENST00000204726 | ENST00000320574 | GOLGA3 | chr12 | 133374926 | - | POLE | chr12 | 133257865 | - |
Frame-shift | ENST00000204726 | ENST00000535270 | GOLGA3 | chr12 | 133398582 | - | POLE | chr12 | 133257865 | - |
Frame-shift | ENST00000204726 | ENST00000535270 | GOLGA3 | chr12 | 133374926 | - | POLE | chr12 | 133257865 | - |
Frame-shift | ENST00000450791 | ENST00000320574 | GOLGA3 | chr12 | 133398582 | - | POLE | chr12 | 133257865 | - |
Frame-shift | ENST00000450791 | ENST00000320574 | GOLGA3 | chr12 | 133374926 | - | POLE | chr12 | 133257865 | - |
Frame-shift | ENST00000450791 | ENST00000535270 | GOLGA3 | chr12 | 133398582 | - | POLE | chr12 | 133257865 | - |
Frame-shift | ENST00000450791 | ENST00000535270 | GOLGA3 | chr12 | 133374926 | - | POLE | chr12 | 133257865 | - |
Frame-shift | ENST00000456883 | ENST00000320574 | GOLGA3 | chr12 | 133398582 | - | POLE | chr12 | 133257865 | - |
Frame-shift | ENST00000456883 | ENST00000320574 | GOLGA3 | chr12 | 133374926 | - | POLE | chr12 | 133257865 | - |
Frame-shift | ENST00000456883 | ENST00000535270 | GOLGA3 | chr12 | 133398582 | - | POLE | chr12 | 133257865 | - |
Frame-shift | ENST00000456883 | ENST00000535270 | GOLGA3 | chr12 | 133374926 | - | POLE | chr12 | 133257865 | - |
Frame-shift | ENST00000537452 | ENST00000320574 | GOLGA3 | chr12 | 133398582 | - | POLE | chr12 | 133257865 | - |
Frame-shift | ENST00000537452 | ENST00000320574 | GOLGA3 | chr12 | 133374926 | - | POLE | chr12 | 133257865 | - |
Frame-shift | ENST00000537452 | ENST00000535270 | GOLGA3 | chr12 | 133398582 | - | POLE | chr12 | 133257865 | - |
Frame-shift | ENST00000537452 | ENST00000535270 | GOLGA3 | chr12 | 133374926 | - | POLE | chr12 | 133257865 | - |
Frame-shift | ENST00000545875 | ENST00000320574 | GOLGA3 | chr12 | 133374926 | - | POLE | chr12 | 133257865 | - |
Frame-shift | ENST00000545875 | ENST00000535270 | GOLGA3 | chr12 | 133374926 | - | POLE | chr12 | 133257865 | - |
In-frame | ENST00000545875 | ENST00000320574 | GOLGA3 | chr12 | 133398582 | - | POLE | chr12 | 133257865 | - |
In-frame | ENST00000545875 | ENST00000535270 | GOLGA3 | chr12 | 133398582 | - | POLE | chr12 | 133257865 | - |
intron-3CDS | ENST00000534967 | ENST00000320574 | GOLGA3 | chr12 | 133398582 | - | POLE | chr12 | 133257865 | - |
intron-3CDS | ENST00000534967 | ENST00000320574 | GOLGA3 | chr12 | 133374926 | - | POLE | chr12 | 133257865 | - |
intron-3CDS | ENST00000534967 | ENST00000535270 | GOLGA3 | chr12 | 133398582 | - | POLE | chr12 | 133257865 | - |
intron-3CDS | ENST00000534967 | ENST00000535270 | GOLGA3 | chr12 | 133374926 | - | POLE | chr12 | 133257865 | - |
intron-intron | ENST00000534967 | ENST00000434528 | GOLGA3 | chr12 | 133398582 | - | POLE | chr12 | 133257865 | - |
intron-intron | ENST00000534967 | ENST00000434528 | GOLGA3 | chr12 | 133374926 | - | POLE | chr12 | 133257865 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000545875 | GOLGA3 | chr12 | 133398582 | - | ENST00000320574 | POLE | chr12 | 133257865 | - | 8088 | 354 | 394 | 7152 | 2252 |
ENST00000545875 | GOLGA3 | chr12 | 133398582 | - | ENST00000535270 | POLE | chr12 | 133257865 | - | 7079 | 354 | 394 | 7071 | 2225 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000545875 | ENST00000320574 | GOLGA3 | chr12 | 133398582 | - | POLE | chr12 | 133257865 | - | 0.004130032 | 0.99586993 |
ENST00000545875 | ENST00000535270 | GOLGA3 | chr12 | 133398582 | - | POLE | chr12 | 133257865 | - | 0.004941145 | 0.9950589 |
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Fusion Genomic Features for GOLGA3-POLE |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for GOLGA3-POLE |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:133248801/chr12:133360893) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | POLE | chr12:133398582 | chr12:133257865 | ENST00000320574 | 0 | 49 | 2221_2238 | 20 | 2287.0 | Motif | CysB motif | |
Tgene | POLE | chr12:133398582 | chr12:133257865 | ENST00000320574 | 0 | 49 | 2158_2190 | 20 | 2287.0 | Zinc finger | CysA-type |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | GOLGA3 | chr12:133398582 | chr12:133257865 | ENST00000204726 | - | 2 | 24 | 394_1459 | 44 | 1499.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | GOLGA3 | chr12:133398582 | chr12:133257865 | ENST00000450791 | - | 1 | 23 | 394_1459 | 44 | 1499.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | GOLGA3 | chr12:133398582 | chr12:133257865 | ENST00000456883 | - | 2 | 22 | 394_1459 | 44 | 1391.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | GOLGA3 | chr12:133398582 | chr12:133257865 | ENST00000537452 | - | 1 | 15 | 394_1459 | 44 | 1135.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | GOLGA3 | chr12:133398582 | chr12:133257865 | ENST00000545875 | - | 2 | 16 | 394_1459 | 44 | 1135.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | GOLGA3 | chr12:133398582 | chr12:133257865 | ENST00000204726 | - | 2 | 24 | 1231_1369 | 44 | 1499.0 | Compositional bias | Note=Gln-rich |
Hgene | GOLGA3 | chr12:133398582 | chr12:133257865 | ENST00000204726 | - | 2 | 24 | 20_95 | 44 | 1499.0 | Compositional bias | Note=Pro-rich |
Hgene | GOLGA3 | chr12:133398582 | chr12:133257865 | ENST00000204726 | - | 2 | 24 | 538_744 | 44 | 1499.0 | Compositional bias | Note=Gln-rich |
Hgene | GOLGA3 | chr12:133398582 | chr12:133257865 | ENST00000450791 | - | 1 | 23 | 1231_1369 | 44 | 1499.0 | Compositional bias | Note=Gln-rich |
Hgene | GOLGA3 | chr12:133398582 | chr12:133257865 | ENST00000450791 | - | 1 | 23 | 20_95 | 44 | 1499.0 | Compositional bias | Note=Pro-rich |
Hgene | GOLGA3 | chr12:133398582 | chr12:133257865 | ENST00000450791 | - | 1 | 23 | 538_744 | 44 | 1499.0 | Compositional bias | Note=Gln-rich |
Hgene | GOLGA3 | chr12:133398582 | chr12:133257865 | ENST00000456883 | - | 2 | 22 | 1231_1369 | 44 | 1391.0 | Compositional bias | Note=Gln-rich |
Hgene | GOLGA3 | chr12:133398582 | chr12:133257865 | ENST00000456883 | - | 2 | 22 | 20_95 | 44 | 1391.0 | Compositional bias | Note=Pro-rich |
Hgene | GOLGA3 | chr12:133398582 | chr12:133257865 | ENST00000456883 | - | 2 | 22 | 538_744 | 44 | 1391.0 | Compositional bias | Note=Gln-rich |
Hgene | GOLGA3 | chr12:133398582 | chr12:133257865 | ENST00000537452 | - | 1 | 15 | 1231_1369 | 44 | 1135.0 | Compositional bias | Note=Gln-rich |
Hgene | GOLGA3 | chr12:133398582 | chr12:133257865 | ENST00000537452 | - | 1 | 15 | 20_95 | 44 | 1135.0 | Compositional bias | Note=Pro-rich |
Hgene | GOLGA3 | chr12:133398582 | chr12:133257865 | ENST00000537452 | - | 1 | 15 | 538_744 | 44 | 1135.0 | Compositional bias | Note=Gln-rich |
Hgene | GOLGA3 | chr12:133398582 | chr12:133257865 | ENST00000545875 | - | 2 | 16 | 1231_1369 | 44 | 1135.0 | Compositional bias | Note=Gln-rich |
Hgene | GOLGA3 | chr12:133398582 | chr12:133257865 | ENST00000545875 | - | 2 | 16 | 20_95 | 44 | 1135.0 | Compositional bias | Note=Pro-rich |
Hgene | GOLGA3 | chr12:133398582 | chr12:133257865 | ENST00000545875 | - | 2 | 16 | 538_744 | 44 | 1135.0 | Compositional bias | Note=Gln-rich |
Hgene | GOLGA3 | chr12:133398582 | chr12:133257865 | ENST00000204726 | - | 2 | 24 | 172_257 | 44 | 1499.0 | Region | Note=Golgi-targeting domain |
Hgene | GOLGA3 | chr12:133398582 | chr12:133257865 | ENST00000450791 | - | 1 | 23 | 172_257 | 44 | 1499.0 | Region | Note=Golgi-targeting domain |
Hgene | GOLGA3 | chr12:133398582 | chr12:133257865 | ENST00000456883 | - | 2 | 22 | 172_257 | 44 | 1391.0 | Region | Note=Golgi-targeting domain |
Hgene | GOLGA3 | chr12:133398582 | chr12:133257865 | ENST00000537452 | - | 1 | 15 | 172_257 | 44 | 1135.0 | Region | Note=Golgi-targeting domain |
Hgene | GOLGA3 | chr12:133398582 | chr12:133257865 | ENST00000545875 | - | 2 | 16 | 172_257 | 44 | 1135.0 | Region | Note=Golgi-targeting domain |
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Fusion Gene Sequence for GOLGA3-POLE |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>33879_33879_1_GOLGA3-POLE_GOLGA3_chr12_133398582_ENST00000545875_POLE_chr12_133257865_ENST00000320574_length(transcript)=8088nt_BP=354nt CCGGGCCGGGCGGCCTCCGGGGCTGCCAGAGCAGCAGGGTATCATGATATTAGCTGGTTTGACATCAAGTCATTTGTGAGTCATCAGATC TTCTCCTGAAAATGGGAGACACAGTAGGGCCCCTCCCAGGAGCTCTTGGCTGTTGCTGATGGCAGAAGCCAAGCTTGTCCAAGGTTCACT TGTAGCCCCTCAGCGTCAGCTCAGCTGGTGTCGTCCTGACCATGGACGGCGCGTCGGCCGAGCAAGATGGCCTCCAGGAGGACAGATCCC ACAGTGGCCCCTCGTCTCTCCCCGAGGCCCCACTGAAGCCCCCGGGCCCACTGGTGCCACCTGACCAGCAGGACAAAGTCCAGTGGATGA TGGCGCCACTTCCTCAGTTTCGGCACTCAAGCGCCTGGAACGGAGTCAGTGGACGGATAAGATGGATTTGCGGTTTGGTTTTGAGCGGCT GAAGGAGCCTGGTGAGAAGACAGGCTGGCTCATTAACATGCATCCTACCGAGATTTTAGATGAAGATAAGCGCTTAGGCAGTGCAGTGGA TTACTACTTTATTCAAGATGACGGAAGCAGATTTAAGGTGGCTTTGCCCTATAAACCGTATTTCTACATTGCGACCAGAAAGGGTTGTGA GCGAGAAGTTTCATCTTTTCTCTCCAAGAAGTTTCAGGGCAAAATTGCAAAAGTGGAGACTGTCCCCAAAGAGGATCTGGACTTGCCAAA TCACTTGGTGGGTTTGAAGCGAAATTACATCAGGCTGTCCTTCCACACTGTGGAGGATCTTGTCAAAGTGAGGAAGGAGATCTCCCCTGC CGTGAAGAAGAACAGGGAGCAGGATCACGCCAGCGACGCGTACACAGCTCTGCTTTCCAGTGTTCTGCAGAGGGGCGGTGTCATTACTGA TGAAGAGGAAACCTCTAAGAAGATAGCTGACCAGTTGGACAACATTGTGGACATGCGCGAGTACGATGTTCCCTACCACATCCGCCTCTC CATTGACCTGAAGATCCACGTGGCTCATTGGTACAATGTCAGATACCGAGGAAATGCTTTTCCGGTAGAAATCACCCGCCGAGATGACCT TGTTGAACGACCTGACCCTGTGGTTTTGGCATTTGACATTGAGACGACCAAACTGCCCCTCAAGTTTCCTGATGCTGAGACAGACCAGAT TATGATGATTTCCTACATGATCGATGGCCAGGGCTACCTCATCACCAACAGGGAGATTGTTTCAGAAGATATTGAAGATTTTGAGTTCAC CCCCAAGCCAGAATATGAAGGCCCCTTTTGTGTCTTCAATGAACCCGATGAGGCTCATCTGATCCAAAGGTGGTTTGAACACGTCCAGGA GACCAAACCCACCATCATGGTCACCTACAACGGGGACTTTTTTGACTGGCCATTTGTGGAGGCCCGGGCAGCAGTCCACGGTCTGAGCAT GCAGCAGGAGATAGGCTTCCAGAAGGACAGCCAGGGGGAGTACAAGGCGCCCCAGTGCATCCACATGGACTGCCTCAGGTGGGTGAAGAG GGACAGTTACCTTCCTGTGGGCAGTCATAATCTCAAGGCGGCCGCCAAGGCCAAGCTAGGCTATGATCCCGTGGAGCTAGACCCGGAGGA CATGTGCCGGATGGCCACGGAGCAGCCCCAGACTCTGGCCACGTATTCTGTGTCAGATGCTGTCGCCACTTACTACCTGTACATGAAGTA CGTCCACCCATTCATCTTTGCTCTGTGCACCATTATTCCCATGGAGCCCGACGAGGTGCTGCGGAAGGGCTCTGGCACTCTGTGTGAGGC CTTGCTGATGGTGCAGGCCTTCCACGCCAACATCATCTTCCCCAACAAGCAAGAGCAGGAGTTCAATAAGCTGACGGACGACGGACACGT GCTGGACTCTGAGACCTACGTCGGGGGCCACGTGGAGGCCCTCGAGTCTGGGGTTTTCCGCAGCGATATCCCTTGCCGGTTTAGGATGAA TCCTGCCGCCTTTGACTTCCTGCTGCAGCGGGTTGAGAAGACCTTGCGCCACGCCCTTGAGGAAGAGGAGAAAGTGCCTGTGGAGCAAGT CACCAACTTTGAAGAGGTGTGTGATGAGATTAAGAGCAAGCTTGCCTCCCTGAAGGACGTTCCCAGCCGCATCGAGTGTCCACTCATCTA CCACCTGGACGTGGGGGCCATGTACCCCAACATCATCCTGACCAACCGCCTGCAGCCCTCTGCCATGGTGGACGAAGCCACCTGTGCTGC CTGTGACTTCAATAAGCCTGGAGCAAACTGCCAGCGGAAGATGGCCTGGCAGTGGAGGGGCGAGTTCATGCCAGCCAGTCGCAGCGAATA CCATCGGATCCAGCACCAGCTGGAGTCAGAGAAGTTCCCCCCCTTGTTCCCAGAGGGGCCAGCTCGGGCCTTTCATGAACTGTCCCGCGA GGAACAGGCGAAATACGAGAAGAGAAGGCTGGCGGATTACTGCCGGAAAGCCTACAAGAAGATCCACATCACCAAGGTGGAAGAGCGTCT CACCACCATCTGCCAGCGGGAAAACTCCTTCTACGTGGACACCGTGCGTGCCTTCCGGGACAGGCGTTACGAGTTCAAAGGGCTCCACAA GGTGTGGAAAAAGAAGCTCTCGGCGGCCGTGGAGGTGGGCGACGCGGCTGAGGTGAAGCGCTGCAAGAACATGGAGGTGCTGTATGACTC GCTGCAGCTGGCCCACAAGTGCATCCTGAACTCCTTCTATGGCTATGTCATGCGCAAGGGGGCTCGCTGGTACTCCATGGAGATGGCTGG CATCGTCTGCTTCACAGGGGCCAACATCATCACCCAGGCACGGGAGCTGATCGAGCAGATTGGGAGGCCCTTAGAGCTGGACACAGATGG TATATGGTGCGTCCTGCCCAACAGCTTCCCAGAAAATTTTGTCTTCAAGACGACCAATGTGAAGAAGCCCAAAGTGACCATCTCCTACCC AGGCGCCATGTTGAACATCATGGTCAAGGAAGGCTTCACCAATGACCAGTACCAGGAGCTGGCTGAGCCGTCCTCACTCACCTACGTCAC CCGCTCAGAGAACAGCATCTTTTTTGAGGTTGATGGGCCCTACCTTGCCATGATTCTTCCAGCCTCCAAGGAAGAAGGCAAGAAATTGAA GAAGAGGTATGCTGTGTTCAATGAAGACGGTTCTCTGGCTGAGCTCAAGGGCTTTGAGGTCAAACGCCGCGGGGAACTGCAGCTGATTAA GATCTTCCAATCCTCGGTGTTTGAGGCCTTCCTCAAGGGCAGCACGCTGGAAGAGGTGTATGGCTCTGTAGCCAAGGTGGCTGACTACTG GCTGGACGTGCTGTACAGCAAGGCAGCCAACATGCCTGACTCTGAGCTATTCGAGCTCATCTCTGAGAACCGTTCCATGTCTCGGAAGCT GGAAGATTACGGGGAGCAGAAGTCTACGTCCATCAGCACAGCAAAGCGCCTGGCCGAGTTCCTGGGAGACCAGATGGTCAAGGATGCAGG GCTGAGTTGCCGCTACATCATCTCCCGCAAGCCCGAGGGCTCCCCTGTCACGGAGAGGGCCATCCCACTTGCCATTTTCCAAGCAGAGCC CACGGTGAGGAAGCACTTTCTCCGGAAATGGCTCAAGAGCTCTTCCCTTCAAGACTTTGATATTCGAGCAATTCTGGATTGGGACTACTA CATTGAGCGGCTGGGAAGCGCCATCCAGAAGATCATCACCATCCCTGCGGCCCTGCAGCAGGTAAAGAACCCAGTGCCACGTGTCAAACA CCCCGACTGGCTGCACAAAAAACTGCTGGAGAAGAATGATGTCTACAAGCAGAAGAAGATCAGTGAGCTCTTCACCCTGGAGGGCAGGAG ACAGGTCACGATGGCCGAGGCCTCAGAAGACAGTCCGAGGCCAAGTGCTCCTGACATGGAGGACTTCGGCCTCGTAAAGCTGCCTCACCC AGCAGCCCCTGTCACTGTGAAGAGGAAGCGAGTTCTTTGGGAGAGCCAGGAGGAGTCCCAGGACCTCACGCCGACTGTGCCCTGGCAGGA AATCTTGGGGCAGCCTCCCGCCCTGGGAACCAGCCAGGAGGAATGGCTTGTCTGGCTCCGGTTCCACAAGAAGAAGTGGCAGCTGCAGGC CCGGCAGCGCCTCGCCCGCAGGAAGAGGCAGCGTCTGGAGTCGGCAGAGGGTGTGCTCAGGCCCGGGGCCATCCGGGATGGTCCTGCCAC GGGGCTGGGGAGCTTCTTGCGAAGAACTGCCCGCAGCATCCTGGACCTTCCGTGGCAGATTGTGCAGATCAGCGAGACCAGCCAGGCCGG CCTGTTCAGGCTGTGGGCGCTCGTTGGCAGTGACTTGCACTGCATCAGGCTGAGCATCCCCCGTGTGTTCTACGTGAACCAGCGAGTCGC TAAAGCGGAGGAGGGTGCTTCGTATCGCAAGGTAAATCGGGTCCTTCCTCGCTCCAACATGGTCTACAATCTCTATGAGTATTCAGTGCC AGAGGACATGTACCAGGAACACATCAACGAGATCAACGCTGAGCTGTCAGCGCCAGACATCGAGGGCGTATATGAGACTCAGGTTCCGTT ACTGTTCCGGGCCCTGGTGCACCTGGGCTGTGTGTGTGTGGTCAATAAACAGCTGGTGAGGCACCTTTCAGGCTGGGAAGCAGAGACCTT TGCTCTTGAGCACCTGGAGATGCGCTCTCTGGCCCAGTTCAGCTACCTGGAACCAGGGAGTATCCGCCATATCTACCTGTACCACCACGC ACAGGCCCACAAAGCGCTCTTCGGGATCTTCATCCCCTCACAGCGCAGGGCATCCGTCTTTGTGCTGGACACTGTGCGCAGCAACCAGAT GCCCAGCCTTGGCGCCCTGTACTCAGCAGAGCACGGCCTCCTCCTGGAGAAGGTGGGCCCTGAGCTCCTGCCACCCCCCAAACACACCTT CGAAGTTCGGGCAGAAACTGACCTGAAGACCATCTGCAGAGCCATCCAGCGATTCCTGCTCGCCTACAAGGAGGAGCGCCGGGGGCCCAC ACTCATCGCTGTTCAGTCCAGCTGGGAGCTGAAGAGGCTGGCCAGTGAAATTCCTGTCTTGGAGGAATTCCCACTGGTGCCTATCTGTGT GGCTGACAAGATCAACTATGGGGTCCTGGACTGGCAGCGCCATGGAGCCCGGCGCATGATCCGTCACTACCTCAACCTGGACACCTGCCT GTCGCAGGCCTTCGAGATGAGCAGGTACTTTCACATTCCCATTGGGAACCTACCAGAGGACATCTCCACATTCGGCTCCGACCTCTTCTT TGCCCGCCACCTCCAGCGCCACAACCACCTGCTCTGGCTGTCCCCTACAGCCCGCCCTGACCTGGGTGGAAAGGAGGCTGATGACAACTG TCTTGTCATGGAGTTCGATGACCAAGCCACTGTTGAGATCAACAGTTCAGGCTGTTACTCCACAGTGTGTGTGGAGCTGGACCTTCAGAA CCTGGCCGTCAACACCATTCTCCAGTCTCACCATGTCAACGACATGGAGGGGGCCGACAGCATGGGGATCAGCTTCGACGTGATCCAGCA GGCCTCCCTGGAGGACATGATCACGGGTGGTCAGGCTGCCAGTGCCCCGGCCAGCTACGATGAGACAGCCCTGTGCTCTAACACCTTCAG GATCCTGAAGAGCATGGTCGTGGGCTGGGTGAAGGAGATCACCCAGTACCACAACATCTATGCAGACAACCAGGTGATGCACTTCTACCG CTGGCTTCGGTCGCCATCCTCTCTGCTTCATGACCCTGCCCTGCACCGCACACTCCACAACATGATGAAGAAGCTCTTCCTGCAGCTCAT CGCTGAGTTCAAGCGCCTGGGGTCATCAGTCATCTACGCCAACTTCAACCGCATCATCCTCTGTACAAAGAAGCGCCGTGTGGAAGATGC CATCGCTTACGTGGAGTACATCACCAGCAGCATCCATTCAAAGGAGACCTTCCATTCTCTGACAATTTCTTTCTCTCGATGCTGGGAATT TCTTCTCTGGATGGATCCATCTAACTATGGCGGAATCAAAGGAAAAGTTTCATCTCGTATTCACTGTGGACTGCAAGACTCCCAGAAAGC AGGGGGAGCAGAGGATGAGCAGGAAAATGAGGACGATGAGGAGGAAAGAGATGGGGAGGAGGAGGAAGAGGCGGAGGAATCCAACGTGGA GGATTTACTGGAAAACAACTGGAACATTTTGCAGTTTTTGCCACAGGCAGCCTCCTGCCAGAACTACTTCCTCATGATTGTTTCAGCGTA CATCGTGGCCGTGTACCACTGCATGAAGGACGGGCTGAGGCGCAGTGCTCCAGGGAGCACCCCCGTGAGGAGGAGGGGGGCCAGCCAGCT CTCCCAGGAGGCCGAGGGGGCGGTCGGAGCCCTTCCCGGAATGATCACCTTCTCTCAGGATTATGTCGCAAATGAGCTCACTCAGAGCTT CTTCACCATCACTCAGAAGATTCAGAAGAAAGTCACAGGCTCTCGGAACTCCACTGAGCTCTCAGAGATGTTTCCTGTCCTCCCCGGTTC CCACTTGCTGCTCAATAACCCTGCCCTGGAGTTCATCAAATACGTGTGCAAGGTGCTGTCCCTGGACACCAACATCACAAACCAGGTGAA TAAGCTGAACCGAGACCTGCTTCGCCTGGTGGATGTCGGCGAGTTCTCCGAGGAGGCCCAGTTCCGAGACCCCTGCCGCTCCTACGTGCT TCCTGAGGTCATCTGCCGCAGCTGTAACTTCTGCCGCGACCTGGACCTGTGTAAAGACTCTTCCTTCTCAGAGGATGGGGCGGTCCTGCC TCAGTGGCTCTGCTCCAACTGTCAGGCGCCCTACGACTCCTCTGCCATCGAGATGACGCTGGTGGAAGTTCTACAGAAGAAGCTGATGGC CTTCACCCTGCAGGACCTGGTCTGCCTGAAGTGCCGCGGGGTGAAGGAGACCAGCATGCCTGTGTACTGCAGCTGCGCGGGAGACTTCGC CCTCACCATCCACACCCAGGTCTTCATGGAACAGATCGGAATATTCCGGAACATTGCCCAGCACTACGGCATGTCGTACCTCCTGGAGAC CCTGGAGTGGCTGCTGCAGAAGAACCCACAGCTGGGCCATTAGCCAGCCCCGGGCCCCGGGTGCCTCTGCGTCCGTGCCAGGCCTCCTGA TGCCAAGGCCACATCCCCGTGCTTCCAGTGACCAGACCACTGACCACCCTGACTGTCCAAACCTGTGACCCCAGGCCAGGGAACGGGGAG GAAACCAAAGAAAACCATTTTCAGGGAGCTCAGACGTCACAGGAGGGAGCGGGAGCAGGATGTGGCCCTGGCCTCGCCAGAGCACCTGAA GAAGCAGGCCGTGAGCGAGGCTGCGAGTGCCCTGGGCGCCGTTTCTCACGCAGTGAATGCTTTTCCAGGCCTCTGTTGCTTCCTGCACCA CACCTGGTGGGGTGGGAGCGTCCTCTAGGTGCCCCTAGTTCTTTGTCCTGCCTCCCAGAGGGAGGAAAAGCCCCTGGGGGCTTCTGGCTC CCTGAGATTGGGCTCTGAGACGAGACGGGTTCCCAAGGCCCTGGTGGGGCTGGAGTCTCACCTGTTTGCATGGAGAAATGGGCTGGCCCC ACAGCCTCACAGGAGCAGTTTGTGGGCTGGTTTCCCCAGGAATCCAGACCCTAACCCGTGAGAATCTGGATTTTGGCTTGTGAGCCCTGC TTATTTGGAGCCGGGTCTAGAGGGAACCCTCTATCAGCCTCAGGAAAACAAGACCTCTGTGCACCTCACTTTTGGCTCACTGCAGCCCTT GTCCTTCACCTCCACACAGGACCAGCTGGAAGCAGAAAGAAGAAAGGCCAATTTCACAGGGCACCAAACAAGTATGAAATGTAAATCAGA AATGCAGACACCCCAGACGAGAGCCTCACAGGAGGGAGGGGGCCCCACAGGCTCCCCAGGAGGCTCGTGTCTTTGGCCCAGAGCCAGCCT >33879_33879_1_GOLGA3-POLE_GOLGA3_chr12_133398582_ENST00000545875_POLE_chr12_133257865_ENST00000320574_length(amino acids)=2252AA_BP= MERSQWTDKMDLRFGFERLKEPGEKTGWLINMHPTEILDEDKRLGSAVDYYFIQDDGSRFKVALPYKPYFYIATRKGCEREVSSFLSKKF QGKIAKVETVPKEDLDLPNHLVGLKRNYIRLSFHTVEDLVKVRKEISPAVKKNREQDHASDAYTALLSSVLQRGGVITDEEETSKKIADQ LDNIVDMREYDVPYHIRLSIDLKIHVAHWYNVRYRGNAFPVEITRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMIDGQG YLITNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDEAHLIQRWFEHVQETKPTIMVTYNGDFFDWPFVEARAAVHGLSMQQEIGFQKDSQ GEYKAPQCIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRMATEQPQTLATYSVSDAVATYYLYMKYVHPFIFALCTI IPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEQEFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIPCRFRMNPAAFDFLLQRV EKTLRHALEEEEKVPVEQVTNFEEVCDEIKSKLASLKDVPSRIECPLIYHLDVGAMYPNIILTNRLQPSAMVDEATCAACDFNKPGANCQ RKMAWQWRGEFMPASRSEYHRIQHQLESEKFPPLFPEGPARAFHELSREEQAKYEKRRLADYCRKAYKKIHITKVEERLTTICQRENSFY VDTVRAFRDRRYEFKGLHKVWKKKLSAAVEVGDAAEVKRCKNMEVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCFTGANIIT QARELIEQIGRPLELDTDGIWCVLPNSFPENFVFKTTNVKKPKVTISYPGAMLNIMVKEGFTNDQYQELAEPSSLTYVTRSENSIFFEVD GPYLAMILPASKEEGKKLKKRYAVFNEDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGSTLEEVYGSVAKVADYWLDVLYSKAANM PDSELFELISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYIISRKPEGSPVTERAIPLAIFQAEPTVRKHFLRKWL KSSSLQDFDIRAILDWDYYIERLGSAIQKIITIPAALQQVKNPVPRVKHPDWLHKKLLEKNDVYKQKKISELFTLEGRRQVTMAEASEDS PRPSAPDMEDFGLVKLPHPAAPVTVKRKRVLWESQEESQDLTPTVPWQEILGQPPALGTSQEEWLVWLRFHKKKWQLQARQRLARRKRQR LESAEGVLRPGAIRDGPATGLGSFLRRTARSILDLPWQIVQISETSQAGLFRLWALVGSDLHCIRLSIPRVFYVNQRVAKAEEGASYRKV NRVLPRSNMVYNLYEYSVPEDMYQEHINEINAELSAPDIEGVYETQVPLLFRALVHLGCVCVVNKQLVRHLSGWEAETFALEHLEMRSLA QFSYLEPGSIRHIYLYHHAQAHKALFGIFIPSQRRASVFVLDTVRSNQMPSLGALYSAEHGLLLEKVGPELLPPPKHTFEVRAETDLKTI CRAIQRFLLAYKEERRGPTLIAVQSSWELKRLASEIPVLEEFPLVPICVADKINYGVLDWQRHGARRMIRHYLNLDTCLSQAFEMSRYFH IPIGNLPEDISTFGSDLFFARHLQRHNHLLWLSPTARPDLGGKEADDNCLVMEFDDQATVEINSSGCYSTVCVELDLQNLAVNTILQSHH VNDMEGADSMGISFDVIQQASLEDMITGGQAASAPASYDETALCSNTFRILKSMVVGWVKEITQYHNIYADNQVMHFYRWLRSPSSLLHD PALHRTLHNMMKKLFLQLIAEFKRLGSSVIYANFNRIILCTKKRRVEDAIAYVEYITSSIHSKETFHSLTISFSRCWEFLLWMDPSNYGG IKGKVSSRIHCGLQDSQKAGGAEDEQENEDDEEERDGEEEEEAEESNVEDLLENNWNILQFLPQAASCQNYFLMIVSAYIVAVYHCMKDG LRRSAPGSTPVRRRGASQLSQEAEGAVGALPGMITFSQDYVANELTQSFFTITQKIQKKVTGSRNSTELSEMFPVLPGSHLLLNNPALEF IKYVCKVLSLDTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICRSCNFCRDLDLCKDSSFSEDGAVLPQWLCSNCQAPY DSSAIEMTLVEVLQKKLMAFTLQDLVCLKCRGVKETSMPVYCSCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLLQKNPQL -------------------------------------------------------------- >33879_33879_2_GOLGA3-POLE_GOLGA3_chr12_133398582_ENST00000545875_POLE_chr12_133257865_ENST00000535270_length(transcript)=7079nt_BP=354nt CCGGGCCGGGCGGCCTCCGGGGCTGCCAGAGCAGCAGGGTATCATGATATTAGCTGGTTTGACATCAAGTCATTTGTGAGTCATCAGATC TTCTCCTGAAAATGGGAGACACAGTAGGGCCCCTCCCAGGAGCTCTTGGCTGTTGCTGATGGCAGAAGCCAAGCTTGTCCAAGGTTCACT TGTAGCCCCTCAGCGTCAGCTCAGCTGGTGTCGTCCTGACCATGGACGGCGCGTCGGCCGAGCAAGATGGCCTCCAGGAGGACAGATCCC ACAGTGGCCCCTCGTCTCTCCCCGAGGCCCCACTGAAGCCCCCGGGCCCACTGGTGCCACCTGACCAGCAGGACAAAGTCCAGTGGATGA TGGCGCCACTTCCTCAGTTTCGGCACTCAAGCGCCTGGAACGGAGTCAGTGGACGGATAAGATGGATTTGCGGTTTGGTTTTGAGCGGCT GAAGGAGCCTGGTGAGAAGACAGGCTGGCTCATTAACATGCATCCTGTGGCTTTGCCCTATAAACCGTATTTCTACATTGCGACCAGAAA GGGTTGTGAGCGAGAAGTTTCATCTTTTCTCTCCAAGAAGTTTCAGGGCAAAATTGCAAAAGTGGAGACTGTCCCCAAAGAGGATCTGGA CTTGCCAAATCACTTGGTGGGTTTGAAGCGAAATTACATCAGGCTGTCCTTCCACACTGTGGAGGATCTTGTCAAAGTGAGGAAGGAGAT CTCCCCTGCCGTGAAGAAGAACAGGGAGCAGGATCACGCCAGCGACGCGTACACAGCTCTGCTTTCCAGTGTTCTGCAGAGGGGCGGTGT CATTACTGATGAAGAGGAAACCTCTAAGAAGATAGCTGACCAGTTGGACAACATTGTGGACATGCGCGAGTACGATGTTCCCTACCACAT CCGCCTCTCCATTGACCTGAAGATCCACGTGGCTCATTGGTACAATGTCAGATACCGAGGAAATGCTTTTCCGGTAGAAATCACCCGCCG AGATGACCTTGTTGAACGACCTGACCCTGTGGTTTTGGCATTTGACATTGAGACGACCAAACTGCCCCTCAAGTTTCCTGATGCTGAGAC AGACCAGATTATGATGATTTCCTACATGATCGATGGCCAGGGCTACCTCATCACCAACAGGGAGATTGTTTCAGAAGATATTGAAGATTT TGAGTTCACCCCCAAGCCAGAATATGAAGGCCCCTTTTGTGTCTTCAATGAACCCGATGAGGCTCATCTGATCCAAAGGTGGTTTGAACA CGTCCAGGAGACCAAACCCACCATCATGGTCACCTACAACGGGGACTTTTTTGACTGGCCATTTGTGGAGGCCCGGGCAGCAGTCCACGG TCTGAGCATGCAGCAGGAGATAGGCTTCCAGAAGGACAGCCAGGGGGAGTACAAGGCGCCCCAGTGCATCCACATGGACTGCCTCAGGTG GGTGAAGAGGGACAGTTACCTTCCTGTGGGCAGTCATAATCTCAAGGCGGCCGCCAAGGCCAAGCTAGGCTATGATCCCGTGGAGCTAGA CCCGGAGGACATGTGCCGGATGGCCACGGAGCAGCCCCAGACTCTGGCCACGTATTCTGTGTCAGATGCTGTCGCCACTTACTACCTGTA CATGAAGTACGTCCACCCATTCATCTTTGCTCTGTGCACCATTATTCCCATGGAGCCCGACGAGGTGCTGCGGAAGGGCTCTGGCACTCT GTGTGAGGCCTTGCTGATGGTGCAGGCCTTCCACGCCAACATCATCTTCCCCAACAAGCAAGAGCAGGAGTTCAATAAGCTGACGGACGA CGGACACGTGCTGGACTCTGAGACCTACGTCGGGGGCCACGTGGAGGCCCTCGAGTCTGGGGTTTTCCGCAGCGATATCCCTTGCCGGTT TAGGATGAATCCTGCCGCCTTTGACTTCCTGCTGCAGCGGGTTGAGAAGACCTTGCGCCACGCCCTTGAGGAAGAGGAGAAAGTGCCTGT GGAGCAAGTCACCAACTTTGAAGAGGTGTGTGATGAGATTAAGAGCAAGCTTGCCTCCCTGAAGGACGTTCCCAGCCGCATCGAGTGTCC ACTCATCTACCACCTGGACGTGGGGGCCATGTACCCCAACATCATCCTGACCAACCGCCTGCAGCCCTCTGCCATGGTGGACGAAGCCAC CTGTGCTGCCTGTGACTTCAATAAGCCTGGAGCAAACTGCCAGCGGAAGATGGCCTGGCAGTGGAGGGGCGAGTTCATGCCAGCCAGTCG CAGCGAATACCATCGGATCCAGCACCAGCTGGAGTCAGAGAAGTTCCCCCCCTTGTTCCCAGAGGGGCCAGCTCGGGCCTTTCATGAACT GTCCCGCGAGGAACAGGCGAAATACGAGAAGAGAAGGCTGGCGGATTACTGCCGGAAAGCCTACAAGAAGATCCACATCACCAAGGTGGA AGAGCGTCTCACCACCATCTGCCAGCGGGAAAACTCCTTCTACGTGGACACCGTGCGTGCCTTCCGGGACAGGCGTTACGAGTTCAAAGG GCTCCACAAGGTGTGGAAAAAGAAGCTCTCGGCGGCCGTGGAGGTGGGCGACGCGGCTGAGGTGAAGCGCTGCAAGAACATGGAGGTGCT GTATGACTCGCTGCAGCTGGCCCACAAGTGCATCCTGAACTCCTTCTATGGCTATGTCATGCGCAAGGGGGCTCGCTGGTACTCCATGGA GATGGCTGGCATCGTCTGCTTCACAGGGGCCAACATCATCACCCAGGCACGGGAGCTGATCGAGCAGATTGGGAGGCCCTTAGAGCTGGA CACAGATGGTATATGGTGCGTCCTGCCCAACAGCTTCCCAGAAAATTTTGTCTTCAAGACGACCAATGTGAAGAAGCCCAAAGTGACCAT CTCCTACCCAGGCGCCATGTTGAACATCATGGTCAAGGAAGGCTTCACCAATGACCAGTACCAGGAGCTGGCTGAGCCGTCCTCACTCAC CTACGTCACCCGCTCAGAGAACAGCATCTTTTTTGAGGTTGATGGGCCCTACCTTGCCATGATTCTTCCAGCCTCCAAGGAAGAAGGCAA GAAATTGAAGAAGAGGTATGCTGTGTTCAATGAAGACGGTTCTCTGGCTGAGCTCAAGGGCTTTGAGGTCAAACGCCGCGGGGAACTGCA GCTGATTAAGATCTTCCAATCCTCGGTGTTTGAGGCCTTCCTCAAGGGCAGCACGCTGGAAGAGGTGTATGGCTCTGTAGCCAAGGTGGC TGACTACTGGCTGGACGTGCTGTACAGCAAGGCAGCCAACATGCCTGACTCTGAGCTATTCGAGCTCATCTCTGAGAACCGTTCCATGTC TCGGAAGCTGGAAGATTACGGGGAGCAGAAGTCTACGTCCATCAGCACAGCAAAGCGCCTGGCCGAGTTCCTGGGAGACCAGATGGTCAA GGATGCAGGGCTGAGTTGCCGCTACATCATCTCCCGCAAGCCCGAGGGCTCCCCTGTCACGGAGAGGGCCATCCCACTTGCCATTTTCCA AGCAGAGCCCACGGTGAGGAAGCACTTTCTCCGGAAATGGCTCAAGAGCTCTTCCCTTCAAGACTTTGATATTCGAGCAATTCTGGATTG GGACTACTACATTGAGCGGCTGGGAAGCGCCATCCAGAAGATCATCACCATCCCTGCGGCCCTGCAGCAGGTAAAGAACCCAGTGCCACG TGTCAAACACCCCGACTGGCTGCACAAAAAACTGCTGGAGAAGAATGATGTCTACAAGCAGAAGAAGATCAGTGAGCTCTTCACCCTGGA GGGCAGGAGACAGGTCACGATGGCCGAGGCCTCAGAAGACAGTCCGAGGCCAAGTGCTCCTGACATGGAGGACTTCGGCCTCGTAAAGCT GCCTCACCCAGCAGCCCCTGTCACTGTGAAGAGGAAGCGAGTTCTTTGGGAGAGCCAGGAGGAGTCCCAGGACCTCACGCCGACTGTGCC CTGGCAGGAAATCTTGGGGCAGCCTCCCGCCCTGGGAACCAGCCAGGAGGAATGGCTTGTCTGGCTCCGGTTCCACAAGAAGAAGTGGCA GCTGCAGGCCCGGCAGCGCCTCGCCCGCAGGAAGAGGCAGCGTCTGGAGTCGGCAGAGGGTGTGCTCAGGCCCGGGGCCATCCGGGATGG TCCTGCCACGGGGCTGGGGAGCTTCTTGCGAAGAACTGCCCGCAGCATCCTGGACCTTCCGTGGCAGATTGTGCAGATCAGCGAGACCAG CCAGGCCGGCCTGTTCAGGCTGTGGGCGCTCGTTGGCAGTGACTTGCACTGCATCAGGCTGAGCATCCCCCGTGTGTTCTACGTGAACCA GCGAGTCGCTAAAGCGGAGGAGGGTGCTTCGTATCGCAAGGTAAATCGGGTCCTTCCTCGCTCCAACATGGTCTACAATCTCTATGAGTA TTCAGTGCCAGAGGACATGTACCAGGAACACATCAACGAGATCAACGCTGAGCTGTCAGCGCCAGACATCGAGGGCGTATATGAGACTCA GGTTCCGTTACTGTTCCGGGCCCTGGTGCACCTGGGCTGTGTGTGTGTGGTCAATAAACAGCTGGTGAGGCACCTTTCAGGCTGGGAAGC AGAGACCTTTGCTCTTGAGCACCTGGAGATGCGCTCTCTGGCCCAGTTCAGCTACCTGGAACCAGGGAGTATCCGCCATATCTACCTGTA CCACCACGCACAGGCCCACAAAGCGCTCTTCGGGATCTTCATCCCCTCACAGCGCAGGGCATCCGTCTTTGTGCTGGACACTGTGCGCAG CAACCAGATGCCCAGCCTTGGCGCCCTGTACTCAGCAGAGCACGGCCTCCTCCTGGAGAAGGTGGGCCCTGAGCTCCTGCCACCCCCCAA ACACACCTTCGAAGTTCGGGCAGAAACTGACCTGAAGACCATCTGCAGAGCCATCCAGCGATTCCTGCTCGCCTACAAGGAGGAGCGCCG GGGGCCCACACTCATCGCTGTTCAGTCCAGCTGGGAGCTGAAGAGGCTGGCCAGTGAAATTCCTGTCTTGGAGGAATTCCCACTGGTGCC TATCTGTGTGGCTGACAAGATCAACTATGGGGTCCTGGACTGGCAGCGCCATGGAGCCCGGCGCATGATCCGTCACTACCTCAACCTGGA CACCTGCCTGTCGCAGGCCTTCGAGATGAGCAGGTACTTTCACATTCCCATTGGGAACCTACCAGAGGACATCTCCACATTCGGCTCCGA CCTCTTCTTTGCCCGCCACCTCCAGCGCCACAACCACCTGCTCTGGCTGTCCCCTACAGCCCGCCCTGACCTGGGTGGAAAGGAGGCTGA TGACAACTGTCTTGTCATGGAGTTCGATGACCAAGCCACTGTTGAGATCAACAGTTCAGGCTGTTACTCCACAGTGTGTGTGGAGCTGGA CCTTCAGAACCTGGCCGTCAACACCATTCTCCAGTCTCACCATGTCAACGACATGGAGGGGGCCGACAGCATGGGGATCAGCTTCGACGT GATCCAGCAGGCCTCCCTGGAGGACATGATCACGGGTGGTCAGGCTGCCAGTGCCCCGGCCAGCTACGATGAGACAGCCCTGTGCTCTAA CACCTTCAGGATCCTGAAGAGCATGGTCGTGGGCTGGGTGAAGGAGATCACCCAGTACCACAACATCTATGCAGACAACCAGGTGATGCA CTTCTACCGCTGGCTTCGGTCGCCATCCTCTCTGCTTCATGACCCTGCCCTGCACCGCACACTCCACAACATGATGAAGAAGCTCTTCCT GCAGCTCATCGCTGAGTTCAAGCGCCTGGGGTCATCAGTCATCTACGCCAACTTCAACCGCATCATCCTCTGTACAAAGAAGCGCCGTGT GGAAGATGCCATCGCTTACGTGGAGTACATCACCAGCAGCATCCATTCAAAGGAGACCTTCCATTCTCTGACAATTTCTTTCTCTCGATG CTGGGAATTTCTTCTCTGGATGGATCCATCTAACTATGGCGGAATCAAAGGAAAAGTTTCATCTCGTATTCACTGTGGACTGCAAGACTC CCAGAAAGCAGGGGGAGCAGAGGATGAGCAGGAAAATGAGGACGATGAGGAGGAAAGAGATGGGGAGGAGGAGGAAGAGGCGGAGGAATC CAACGTGGAGGATTTACTGGAAAACAACTGGAACATTTTGCAGTTTTTGCCACAGGCAGCCTCCTGCCAGAACTACTTCCTCATGATTGT TTCAGCGTACATCGTGGCCGTGTACCACTGCATGAAGGACGGGCTGAGGCGCAGTGCTCCAGGGAGCACCCCCGTGAGGAGGAGGGGGGC CAGCCAGCTCTCCCAGGAGGCCGAGGGGGCGGTCGGAGCCCTTCCCGGAATGATCACCTTCTCTCAGGATTATGTCGCAAATGAGCTCAC TCAGAGCTTCTTCACCATCACTCAGAAGATTCAGAAGAAAGTCACAGGCTCTCGGAACTCCACTGAGCTCTCAGAGATGTTTCCTGTCCT CCCCGGTTCCCACTTGCTGCTCAATAACCCTGCCCTGGAGTTCATCAAATACGTGTGCAAGGTGCTGTCCCTGGACACCAACATCACAAA CCAGGTGAATAAGCTGAACCGAGACCTGCTTCGCCTGGTGGATGTCGGCGAGTTCTCCGAGGAGGCCCAGTTCCGAGACCCCTGCCGCTC CTACGTGCTTCCTGAGGTCATCTGCCGCAGCTGTAACTTCTGCCGCGACCTGGACCTGTGTAAAGACTCTTCCTTCTCAGAGGATGGGGC GGTCCTGCCTCAGTGGCTCTGCTCCAACTGTCAGGCGCCCTACGACTCCTCTGCCATCGAGATGACGCTGGTGGAAGTTCTACAGAAGAA GCTGATGGCCTTCACCCTGCAGGACCTGGTCTGCCTGAAGTGCCGCGGGGTGAAGGAGACCAGCATGCCTGTGTACTGCAGCTGCGCGGG AGACTTCGCCCTCACCATCCACACCCAGGTCTTCATGGAACAGATCGGAATATTCCGGAACATTGCCCAGCACTACGGCATGTCGTACCT >33879_33879_2_GOLGA3-POLE_GOLGA3_chr12_133398582_ENST00000545875_POLE_chr12_133257865_ENST00000535270_length(amino acids)=2225AA_BP= MERSQWTDKMDLRFGFERLKEPGEKTGWLINMHPVALPYKPYFYIATRKGCEREVSSFLSKKFQGKIAKVETVPKEDLDLPNHLVGLKRN YIRLSFHTVEDLVKVRKEISPAVKKNREQDHASDAYTALLSSVLQRGGVITDEEETSKKIADQLDNIVDMREYDVPYHIRLSIDLKIHVA HWYNVRYRGNAFPVEITRRDDLVERPDPVVLAFDIETTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGP FCVFNEPDEAHLIQRWFEHVQETKPTIMVTYNGDFFDWPFVEARAAVHGLSMQQEIGFQKDSQGEYKAPQCIHMDCLRWVKRDSYLPVGS HNLKAAAKAKLGYDPVELDPEDMCRMATEQPQTLATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFH ANIIFPNKQEQEFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIPCRFRMNPAAFDFLLQRVEKTLRHALEEEEKVPVEQVTNFEEVCD EIKSKLASLKDVPSRIECPLIYHLDVGAMYPNIILTNRLQPSAMVDEATCAACDFNKPGANCQRKMAWQWRGEFMPASRSEYHRIQHQLE SEKFPPLFPEGPARAFHELSREEQAKYEKRRLADYCRKAYKKIHITKVEERLTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLSA AVEVGDAAEVKRCKNMEVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCFTGANIITQARELIEQIGRPLELDTDGIWCVLPNS FPENFVFKTTNVKKPKVTISYPGAMLNIMVKEGFTNDQYQELAEPSSLTYVTRSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNE DGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKGSTLEEVYGSVAKVADYWLDVLYSKAANMPDSELFELISENRSMSRKLEDYGEQKS TSISTAKRLAEFLGDQMVKDAGLSCRYIISRKPEGSPVTERAIPLAIFQAEPTVRKHFLRKWLKSSSLQDFDIRAILDWDYYIERLGSAI QKIITIPAALQQVKNPVPRVKHPDWLHKKLLEKNDVYKQKKISELFTLEGRRQVTMAEASEDSPRPSAPDMEDFGLVKLPHPAAPVTVKR KRVLWESQEESQDLTPTVPWQEILGQPPALGTSQEEWLVWLRFHKKKWQLQARQRLARRKRQRLESAEGVLRPGAIRDGPATGLGSFLRR TARSILDLPWQIVQISETSQAGLFRLWALVGSDLHCIRLSIPRVFYVNQRVAKAEEGASYRKVNRVLPRSNMVYNLYEYSVPEDMYQEHI NEINAELSAPDIEGVYETQVPLLFRALVHLGCVCVVNKQLVRHLSGWEAETFALEHLEMRSLAQFSYLEPGSIRHIYLYHHAQAHKALFG IFIPSQRRASVFVLDTVRSNQMPSLGALYSAEHGLLLEKVGPELLPPPKHTFEVRAETDLKTICRAIQRFLLAYKEERRGPTLIAVQSSW ELKRLASEIPVLEEFPLVPICVADKINYGVLDWQRHGARRMIRHYLNLDTCLSQAFEMSRYFHIPIGNLPEDISTFGSDLFFARHLQRHN HLLWLSPTARPDLGGKEADDNCLVMEFDDQATVEINSSGCYSTVCVELDLQNLAVNTILQSHHVNDMEGADSMGISFDVIQQASLEDMIT GGQAASAPASYDETALCSNTFRILKSMVVGWVKEITQYHNIYADNQVMHFYRWLRSPSSLLHDPALHRTLHNMMKKLFLQLIAEFKRLGS SVIYANFNRIILCTKKRRVEDAIAYVEYITSSIHSKETFHSLTISFSRCWEFLLWMDPSNYGGIKGKVSSRIHCGLQDSQKAGGAEDEQE NEDDEEERDGEEEEEAEESNVEDLLENNWNILQFLPQAASCQNYFLMIVSAYIVAVYHCMKDGLRRSAPGSTPVRRRGASQLSQEAEGAV GALPGMITFSQDYVANELTQSFFTITQKIQKKVTGSRNSTELSEMFPVLPGSHLLLNNPALEFIKYVCKVLSLDTNITNQVNKLNRDLLR LVDVGEFSEEAQFRDPCRSYVLPEVICRSCNFCRDLDLCKDSSFSEDGAVLPQWLCSNCQAPYDSSAIEMTLVEVLQKKLMAFTLQDLVC -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for GOLGA3-POLE |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | GOLGA3 | chr12:133398582 | chr12:133257865 | ENST00000204726 | - | 2 | 24 | 121_141 | 44.333333333333336 | 1499.0 | GOPC |
Hgene | GOLGA3 | chr12:133398582 | chr12:133257865 | ENST00000450791 | - | 1 | 23 | 121_141 | 44.333333333333336 | 1499.0 | GOPC |
Hgene | GOLGA3 | chr12:133398582 | chr12:133257865 | ENST00000456883 | - | 2 | 22 | 121_141 | 44.333333333333336 | 1391.0 | GOPC |
Hgene | GOLGA3 | chr12:133398582 | chr12:133257865 | ENST00000537452 | - | 1 | 15 | 121_141 | 44.333333333333336 | 1135.0 | GOPC |
Hgene | GOLGA3 | chr12:133398582 | chr12:133257865 | ENST00000545875 | - | 2 | 16 | 121_141 | 44.333333333333336 | 1135.0 | GOPC |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for GOLGA3-POLE |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for GOLGA3-POLE |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |