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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:AKAP9-BRAF (FusionGDB2 ID:3390) |
Fusion Gene Summary for AKAP9-BRAF |
Fusion gene summary |
Fusion gene information | Fusion gene name: AKAP9-BRAF | Fusion gene ID: 3390 | Hgene | Tgene | Gene symbol | AKAP9 | BRAF | Gene ID | 10142 | 673 |
Gene name | A-kinase anchoring protein 9 | B-Raf proto-oncogene, serine/threonine kinase | |
Synonyms | AKAP-9|AKAP350|AKAP450|CG-NAP|HYPERION|LQT11|MU-RMS-40.16A|PPP1R45|PRKA9|YOTIAO | B-RAF1|B-raf|BRAF1|NS7|RAFB1 | |
Cytomap | 7q21.2 | 7q34 | |
Type of gene | protein-coding | protein-coding | |
Description | A-kinase anchor protein 9A kinase (PRKA) anchor protein (yotiao) 9A kinase (PRKA) anchor protein 9A-kinase anchor protein 350 kDaA-kinase anchor protein 450 kDaAKAP 120-like proteinAKAP9-BRAF fusion proteincentrosome- and Golgi-localized PKN-associ | serine/threonine-protein kinase B-raf94 kDa B-raf proteinB-Raf proto-oncogene serine/threonine-protein kinase (p94)B-Raf serine/threonine-proteinmurine sarcoma viral (v-raf) oncogene homolog B1proto-oncogene B-Rafv-raf murine sarcoma viral oncogene | |
Modification date | 20200328 | 20200329 | |
UniProtAcc | Q99996 | P15056 | |
Ensembl transtripts involved in fusion gene | ENST00000356239, ENST00000358100, ENST00000359028, ENST00000394564, ENST00000491695, | ENST00000288602, | |
Fusion gene scores | * DoF score | 17 X 21 X 11=3927 | 48 X 58 X 16=44544 |
# samples | 28 | 69 | |
** MAII score | log2(28/3927*10)=-3.80992886572143 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(69/44544*10)=-6.0124909441832 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: AKAP9 [Title/Abstract] AND BRAF [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | AKAP9(91632550)-BRAF(140434354), # samples:1 AKAP9(91632550)-BRAF(140487386), # samples:1 AKAP9(91739875)-BRAF(140513187), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | AKAP9 | GO:0098962 | regulation of postsynaptic neurotransmitter receptor activity | 10390370 |
Hgene | AKAP9 | GO:1903358 | regulation of Golgi organization | 27666745 |
Tgene | BRAF | GO:0000186 | activation of MAPKK activity | 29433126 |
Tgene | BRAF | GO:0006468 | protein phosphorylation | 17563371 |
Tgene | BRAF | GO:0010828 | positive regulation of glucose transmembrane transport | 23010278 |
Tgene | BRAF | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 19667065 |
Tgene | BRAF | GO:0043066 | negative regulation of apoptotic process | 19667065 |
Tgene | BRAF | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 22065586 |
Tgene | BRAF | GO:0071277 | cellular response to calcium ion | 18567582 |
Tgene | BRAF | GO:0090150 | establishment of protein localization to membrane | 23010278 |
Fusion gene breakpoints across AKAP9 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across BRAF (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | thyroid cancer | AY803272 | AKAP9 | chr7 | 91632550 | BRAF | chr7 | 140434354 | ||
ChimerKB3 | . | . | AKAP9 | chr7 | 91470486 | + | BRAF | chr7 | 140080822 | - |
ChimerKB3 | . | . | AKAP9 | chr7 | 91632549 | - | BRAF | chr7 | 140487384 | + |
ChimerKB3 | . | . | AKAP9 | chr7 | 91632549 | + | BRAF | chr7 | 140487384 | - |
ChiTaRS5.0 | N/A | AY803272 | AKAP9 | chr7 | 91632550 | + | BRAF | chr7 | 140487386 | - |
ChiTaRS5.0 | N/A | FN170090 | AKAP9 | chr7 | 91739875 | + | BRAF | chr7 | 140513187 | + |
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Fusion Gene ORF analysis for AKAP9-BRAF |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000356239 | ENST00000288602 | AKAP9 | chr7 | 91739875 | + | BRAF | chr7 | 140513187 | + |
3UTR-intron | ENST00000358100 | ENST00000288602 | AKAP9 | chr7 | 91739875 | + | BRAF | chr7 | 140513187 | + |
3UTR-intron | ENST00000359028 | ENST00000288602 | AKAP9 | chr7 | 91739875 | + | BRAF | chr7 | 140513187 | + |
5CDS-3UTR | ENST00000356239 | ENST00000288602 | AKAP9 | chr7 | 91632550 | BRAF | chr7 | 140434354 | ||
5CDS-3UTR | ENST00000358100 | ENST00000288602 | AKAP9 | chr7 | 91632550 | BRAF | chr7 | 140434354 | ||
5CDS-3UTR | ENST00000359028 | ENST00000288602 | AKAP9 | chr7 | 91632550 | BRAF | chr7 | 140434354 | ||
In-frame | ENST00000356239 | ENST00000288602 | AKAP9 | chr7 | 91632549 | - | BRAF | chr7 | 140487384 | + |
In-frame | ENST00000356239 | ENST00000288602 | AKAP9 | chr7 | 91632550 | + | BRAF | chr7 | 140487386 | - |
In-frame | ENST00000358100 | ENST00000288602 | AKAP9 | chr7 | 91632549 | - | BRAF | chr7 | 140487384 | + |
In-frame | ENST00000358100 | ENST00000288602 | AKAP9 | chr7 | 91632550 | + | BRAF | chr7 | 140487386 | - |
In-frame | ENST00000359028 | ENST00000288602 | AKAP9 | chr7 | 91632549 | - | BRAF | chr7 | 140487384 | + |
In-frame | ENST00000359028 | ENST00000288602 | AKAP9 | chr7 | 91632550 | + | BRAF | chr7 | 140487386 | - |
intron-3CDS | ENST00000394564 | ENST00000288602 | AKAP9 | chr7 | 91632549 | - | BRAF | chr7 | 140487384 | + |
intron-3CDS | ENST00000394564 | ENST00000288602 | AKAP9 | chr7 | 91632550 | + | BRAF | chr7 | 140487386 | - |
intron-3CDS | ENST00000491695 | ENST00000288602 | AKAP9 | chr7 | 91632549 | - | BRAF | chr7 | 140487384 | + |
intron-3CDS | ENST00000491695 | ENST00000288602 | AKAP9 | chr7 | 91632550 | + | BRAF | chr7 | 140487386 | - |
intron-3UTR | ENST00000394564 | ENST00000288602 | AKAP9 | chr7 | 91632550 | BRAF | chr7 | 140434354 | ||
intron-3UTR | ENST00000491695 | ENST00000288602 | AKAP9 | chr7 | 91632550 | BRAF | chr7 | 140434354 | ||
intron-intron | ENST00000356239 | ENST00000288602 | AKAP9 | chr7 | 91470486 | + | BRAF | chr7 | 140080822 | - |
intron-intron | ENST00000358100 | ENST00000288602 | AKAP9 | chr7 | 91470486 | + | BRAF | chr7 | 140080822 | - |
intron-intron | ENST00000359028 | ENST00000288602 | AKAP9 | chr7 | 91470486 | + | BRAF | chr7 | 140080822 | - |
intron-intron | ENST00000394564 | ENST00000288602 | AKAP9 | chr7 | 91470486 | + | BRAF | chr7 | 140080822 | - |
intron-intron | ENST00000394564 | ENST00000288602 | AKAP9 | chr7 | 91739875 | + | BRAF | chr7 | 140513187 | + |
intron-intron | ENST00000491695 | ENST00000288602 | AKAP9 | chr7 | 91470486 | + | BRAF | chr7 | 140080822 | - |
intron-intron | ENST00000491695 | ENST00000288602 | AKAP9 | chr7 | 91739875 | + | BRAF | chr7 | 140513187 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000356239 | AKAP9 | chr7 | 91632549 | - | ENST00000288602 | BRAF | chr7 | 140487384 | + | 4830 | 3551 | 203 | 4711 | 1502 |
ENST00000358100 | AKAP9 | chr7 | 91632549 | - | ENST00000288602 | BRAF | chr7 | 140487384 | + | 4858 | 3579 | 195 | 4739 | 1514 |
ENST00000359028 | AKAP9 | chr7 | 91632549 | - | ENST00000288602 | BRAF | chr7 | 140487384 | + | 4858 | 3579 | 195 | 4739 | 1514 |
ENST00000356239 | AKAP9 | chr7 | 91632550 | + | ENST00000288602 | BRAF | chr7 | 140487386 | - | 4830 | 3551 | 203 | 4711 | 1502 |
ENST00000358100 | AKAP9 | chr7 | 91632550 | + | ENST00000288602 | BRAF | chr7 | 140487386 | - | 4858 | 3579 | 195 | 4739 | 1514 |
ENST00000359028 | AKAP9 | chr7 | 91632550 | + | ENST00000288602 | BRAF | chr7 | 140487386 | - | 4858 | 3579 | 195 | 4739 | 1514 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000356239 | ENST00000288602 | AKAP9 | chr7 | 91632550 | + | BRAF | chr7 | 140487386 | - | 0.001858539 | 0.9981414 |
ENST00000358100 | ENST00000288602 | AKAP9 | chr7 | 91632550 | + | BRAF | chr7 | 140487386 | - | 0.00182913 | 0.99817085 |
ENST00000359028 | ENST00000288602 | AKAP9 | chr7 | 91632550 | + | BRAF | chr7 | 140487386 | - | 0.00182913 | 0.99817085 |
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Fusion Genomic Features for AKAP9-BRAF |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for AKAP9-BRAF |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:91632550/chr7:140434354) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
AKAP9 | BRAF |
FUNCTION: Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus (PubMed:10202149, PubMed:15047863). Required for microtubule nucleation at the cis-side of the Golgi apparatus (PubMed:15047863, PubMed:19242490). Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:25657325). In complex with PDE4DIP isoform 13/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with PDE4DIP isoform 13/MMG8/SMYLE, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery (PubMed:29162697). {ECO:0000269|PubMed:10202149, ECO:0000269|PubMed:15047863, ECO:0000269|PubMed:19242490, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:29162697}.; FUNCTION: [Isoform 4]: Associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations. {ECO:0000269|PubMed:9482789}. | FUNCTION: Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000305}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000356239 | + | 8 | 50 | 152_902 | 1106 | 3908.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000356239 | + | 8 | 50 | 932_1010 | 1106 | 3908.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000358100 | + | 9 | 49 | 152_902 | 1118 | 3858.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000358100 | + | 9 | 49 | 932_1010 | 1118 | 3858.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000359028 | + | 9 | 50 | 152_902 | 1118 | 3912.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000359028 | + | 9 | 50 | 932_1010 | 1118 | 3912.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000356239 | + | 8 | 50 | 191_280 | 1106 | 3908.0 | Compositional bias | Note=Gln-rich |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000356239 | + | 8 | 50 | 309_998 | 1106 | 3908.0 | Compositional bias | Note=Glu-rich |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000358100 | + | 9 | 49 | 191_280 | 1118 | 3858.0 | Compositional bias | Note=Gln-rich |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000358100 | + | 9 | 49 | 309_998 | 1118 | 3858.0 | Compositional bias | Note=Glu-rich |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000359028 | + | 9 | 50 | 191_280 | 1118 | 3912.0 | Compositional bias | Note=Gln-rich |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000359028 | + | 9 | 50 | 309_998 | 1118 | 3912.0 | Compositional bias | Note=Glu-rich |
Tgene | BRAF | chr7:91632550 | chr7:140487386 | ENST00000288602 | 7 | 18 | 428_432 | 380 | 767.0 | Compositional bias | Note=Poly-Ser | |
Tgene | BRAF | chr7:91632550 | chr7:140487386 | ENST00000288602 | 7 | 18 | 457_717 | 380 | 767.0 | Domain | Protein kinase | |
Tgene | BRAF | chr7:91632550 | chr7:140487386 | ENST00000288602 | 7 | 18 | 463_471 | 380 | 767.0 | Nucleotide binding | ATP |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000356239 | + | 8 | 50 | 1088_1173 | 1106 | 3908.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000356239 | + | 8 | 50 | 1241_1268 | 1106 | 3908.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000356239 | + | 8 | 50 | 1324_1380 | 1106 | 3908.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000356239 | + | 8 | 50 | 1422_1447 | 1106 | 3908.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000356239 | + | 8 | 50 | 1573_1647 | 1106 | 3908.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000356239 | + | 8 | 50 | 1845_2443 | 1106 | 3908.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000356239 | + | 8 | 50 | 2532_2549 | 1106 | 3908.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000356239 | + | 8 | 50 | 2591_2764 | 1106 | 3908.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000356239 | + | 8 | 50 | 3061_3088 | 1106 | 3908.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000356239 | + | 8 | 50 | 3120_3466 | 1106 | 3908.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000356239 | + | 8 | 50 | 3583_3685 | 1106 | 3908.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000358100 | + | 9 | 49 | 1088_1173 | 1118 | 3858.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000358100 | + | 9 | 49 | 1241_1268 | 1118 | 3858.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000358100 | + | 9 | 49 | 1324_1380 | 1118 | 3858.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000358100 | + | 9 | 49 | 1422_1447 | 1118 | 3858.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000358100 | + | 9 | 49 | 1573_1647 | 1118 | 3858.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000358100 | + | 9 | 49 | 1845_2443 | 1118 | 3858.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000358100 | + | 9 | 49 | 2532_2549 | 1118 | 3858.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000358100 | + | 9 | 49 | 2591_2764 | 1118 | 3858.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000358100 | + | 9 | 49 | 3061_3088 | 1118 | 3858.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000358100 | + | 9 | 49 | 3120_3466 | 1118 | 3858.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000358100 | + | 9 | 49 | 3583_3685 | 1118 | 3858.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000359028 | + | 9 | 50 | 1088_1173 | 1118 | 3912.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000359028 | + | 9 | 50 | 1241_1268 | 1118 | 3912.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000359028 | + | 9 | 50 | 1324_1380 | 1118 | 3912.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000359028 | + | 9 | 50 | 1422_1447 | 1118 | 3912.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000359028 | + | 9 | 50 | 1573_1647 | 1118 | 3912.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000359028 | + | 9 | 50 | 1845_2443 | 1118 | 3912.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000359028 | + | 9 | 50 | 2532_2549 | 1118 | 3912.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000359028 | + | 9 | 50 | 2591_2764 | 1118 | 3912.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000359028 | + | 9 | 50 | 3061_3088 | 1118 | 3912.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000359028 | + | 9 | 50 | 3120_3466 | 1118 | 3912.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000359028 | + | 9 | 50 | 3583_3685 | 1118 | 3912.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000356239 | + | 8 | 50 | 1834_2760 | 1106 | 3908.0 | Compositional bias | Note=Glu-rich |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000356239 | + | 8 | 50 | 3722_3726 | 1106 | 3908.0 | Compositional bias | Note=Poly-Leu |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000358100 | + | 9 | 49 | 1834_2760 | 1118 | 3858.0 | Compositional bias | Note=Glu-rich |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000358100 | + | 9 | 49 | 3722_3726 | 1118 | 3858.0 | Compositional bias | Note=Poly-Leu |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000359028 | + | 9 | 50 | 1834_2760 | 1118 | 3912.0 | Compositional bias | Note=Glu-rich |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000359028 | + | 9 | 50 | 3722_3726 | 1118 | 3912.0 | Compositional bias | Note=Poly-Leu |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000356239 | + | 8 | 50 | 2542_2555 | 1106 | 3908.0 | Region | Note=PKA-RII subunit binding domain |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000358100 | + | 9 | 49 | 2542_2555 | 1118 | 3858.0 | Region | Note=PKA-RII subunit binding domain |
Hgene | AKAP9 | chr7:91632550 | chr7:140487386 | ENST00000359028 | + | 9 | 50 | 2542_2555 | 1118 | 3912.0 | Region | Note=PKA-RII subunit binding domain |
Tgene | BRAF | chr7:91632550 | chr7:140487386 | ENST00000288602 | 7 | 18 | 122_129 | 380 | 767.0 | Compositional bias | Note=Poly-Ser | |
Tgene | BRAF | chr7:91632550 | chr7:140487386 | ENST00000288602 | 7 | 18 | 6_11 | 380 | 767.0 | Compositional bias | Note=Poly-Gly | |
Tgene | BRAF | chr7:91632550 | chr7:140487386 | ENST00000288602 | 7 | 18 | 155_227 | 380 | 767.0 | Domain | RBD | |
Tgene | BRAF | chr7:91632550 | chr7:140487386 | ENST00000288602 | 7 | 18 | 234_280 | 380 | 767.0 | Zinc finger | Phorbol-ester/DAG-type |
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Fusion Gene Sequence for AKAP9-BRAF |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>3390_3390_1_AKAP9-BRAF_AKAP9_chr7_91632549_ENST00000356239_BRAF_chr7_140487384_ENST00000288602_length(transcript)=4830nt_BP=3551nt TACGTGGAGACGAAGATGGCGGCGGCGGCGGCGGTGACGGCGCTTCCCGTGCGGCTGAGGACGATCCGCCAGTGAGCGCGGAGACTGCTT CCACTTCGGGCGGGGGAGCGCCGGACCGAATCGGCTCTCTAGGCCGTGGAGCTTGCCGTCCCACCTCCGTCCAAATCGACCTTTCCTTTC TATCCCCAACCACCCCTCAACCCCTGTTTTCCCCTGCCTTCCTTGCAGAGGCCATGGAGGACGAGGAGAGACAGAAGAAGCTGGAGGCCG GCAAAGCCAAGCTTGCCCAGTTTCGACAAAGAAAAGCTCAGTCGGATGGGCAGAGTCCTTCCAAGAAGCAGAAAAAAAAGAGAAAAACGT CAAGCAGTAAACATGATGTGTCAGCACACCATGATTTGAATATTGATCAATCACAGTGTAATGAAATGTACATAAATAGTTCTCAGAGAG TAGAATCAACTGTGATTCCTGAATCTACAATAATGAGAACTCTACATAGTGGAGAAATAACCAGTCATGAGCAGGGCTTCTCTGTGGAAC TGGAAAGTGAAATTTCAACCACAGCAGATGACTGCAGTTCAGAGGTAAATGGTTGCAGTTTTGTGATGAGAACAGGAAAGCCTACAAATT TATTAAGGGAAGAAGAATTTGGTGTTGATGATTCTTATTCTGAACAAGGAGCACAAGACAGTCCGACTCATCTAGAGATGATGGAAAGTG AGTTGGCTGGGAAGCAGCATGAGATTGAAGAGCTAAACAGAGAGCTGGAAGAAATGAGGGTTACCTATGGGACTGAAGGACTGCAGCAGT TACAAGAATTTGAAGCTGCCATTAAACAAAGAGATGGCATTATAACCCAGCTCACTGCTAATTTACAACAAGCAAGAAGAGAAAAGGATG AGACAATGAGAGAATTTTTAGAGTTGACAGAACAGAGTCAAAAATTACAGATTCAATTTCAGCAATTACAGGCTAGTGAAACTCTGAGAA ACAGCACTCATAGTAGCACAGCTGCAGACTTACTACAAGCCAAACAACAGATCCTCACTCATCAACAGCAGCTTGAAGAACAAGACCACT TATTAGAAGATTATCAGAAAAAGAAAGAAGACTTCACAATGCAAATTAGTTTCTTGCAAGAGAAAATTAAAGTATATGAAATGGAACAAG ATAAAAAAGTAGAAAACTCAAATAAAGAAGAAATACAGGAAAAGGAGACAATCATTGAAGAATTAAACACAAAAATAATAGAAGAAGAAA AGAAAACTCTTGAGCTAAAGGATAAATTAACAACTGCTGATAAATTACTAGGAGAATTACAAGAACAGATTGTGCAAAAGAACCAAGAAA TAAAAAACATGAAATTAGAGCTGACTAATTCTAAGCAAAAAGAAAGACAGTCTTCTGAAGAAATAAAACAGTTAATGGGGACAGTCGAAG AACTTCAGAAGAGAAATCATAAAGACAGCCAGTTCGAAACTGATATAGTACAACGAATGGAACAAGAAACACAAAGAAAGTTAGAACAAC TCCGGGCAGAGCTGGATGAGATGTATGGGCAGCAGATAGTGCAAATGAAACAAGAATTAATAAGACAACACATGGCACAGATGGAGGAAA TGAAAACACGGCATAAGGGAGAAATGGAGAATGCTTTAAGGTCATATTCAAATATTACAGTTAATGAAGATCAGATAAAGTTAATGAATG TGGCAATAAATGAACTGAATATAAAATTGCAAGATACTAACTCTCAAAAGGAAAAACTCAAGGAAGAACTAGGACTAATTTTAGAAGAAA AGTGTGCTCTACAGAGACAGCTTGAAGACCTTGTTGAAGAATTGAGCTTTTCAAGGGAACAGATTCAGAGAGCTAGACAGACAATAGCTG AACAAGAAAGTAAACTTAATGAAGCACATAAGTCCCTTAGTACAGTGGAAGATTTGAAAGCTGAGATTGTTTCTGCATCTGAATCCAGAA AGGAACTAGAATTAAAACATGAAGCAGAAGTTACAAATTACAAGATAAAACTTGAAATGTTAGAAAAAGAAAAGAATGCTGTGTTAGACA GAATGGCTGAATCACAAGAAGCTGAATTAGAGAGGCTGAGAACACAGCTTCTATTTAGTCACGAAGAAGAGCTTTCCAAACTGAAGGAAG ATTTAGAAATTGAACATCGAATAAATATTGAAAAACTTAAAGATAATTTAGGCATTCACTATAAACAGCAGATAGATGGTTTACAGAATG AAATGAGTCAAAAGATAGAAACCATGCAGTTTGAAAAGGACAATTTGATAACTAAGCAGAATCAATTAATTTTGGAAATTTCAAAGCTAA AAGATTTACAGCAGTCTCTTGTAAATTCAAAGTCAGAAGAAATGACTCTTCAAATCAATGAACTTCAAAAAGAAATTGAAATACTCAGAC AAGAAGAAAAAGAAAAGGGTACACTTGAACAAGAAGTTCAAGAATTACAACTTAAAACAGAATTGTTAGAAAAACAGATGAAGGAAAAAG AGAATGATCTTCAAGAAAAATTTGCACAACTTGAAGCAGAGAATAGCATTCTTAAAGATGAAAAGAAAACCCTTGAAGACATGTTGAAAA TACATACTCCTGTTAGCCAAGAAGAAAGATTGATTTTCTTAGACTCCATTAAGTCCAAATCCAAAGACTCTGTGTGGGAAAAAGAAATAG AAATACTTATAGAGGAAAATGAGGACCTCAAACAACAATGTATTCAGCTAAATGAAGAGATTGAAAAGCAAAGGAACACTTTTTCATTTG CTGAAAAAAACTTTGAAGTTAACTATCAAGAGTTACAAGAGGAGTATGCTTGCCTTCTCAAAGTAAAAGATGATTTAGAAGACAGTAAAA ATAAACAGGAATTAGAGTATAAAAGTAAACTTAAAGCACTTAATGAAGAGCTTCATTTGCAAAGAATAAATCCAACTACAGTGAAAATGA AAAGTTCTGTCTTTGATGAAGACAAAACTTTTGTAGCAGAAACATTGGAAATGGGTGAGGTTGTTGAAAAGGATACAACAGAACTCATGG AAAAACTTGAGGTAACCAAGCGAGAGAAATTAGAGCTGTCACAGAGACTGTCTGATCTTTCTGAACAATTGAAACAGAAACATGGTGAGA TTAGTTTTCTAAATGAAGAAGTTAAATCTTTAAAGCAAGAGAAAGAACAAGTTTCATTGAGATGTAGAGAGCTAGAAATCATTATTAACC ACAACAGGGCAGAAAATGTACAGTCATGTGATACTCAAGTAAGCTCTTTATTAGATGGAGTTGTGACCATGACAAGCAGGGGTGCTGAAG GATCAGTTTCTAAAGTAAATAAAAGTTTTGGTGAAGAATCAAAAATAATGGTGGAAGATAAAGTTTCTTTTGAAAATATGACTGTTGGAG AAGAAAGTAAGCAAGAACAGTTGATTTTGGATCACTTACCATCTGTAACAAAGGAATCATCACTTAGAGCAACTCAACCAAGTGAAAATG ATAAACTTCAGAAAGAACTCAATGTACTTAAATCAGAACAGGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAG GTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGA AGTCATCTTCATCCTCAGAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGA TTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATG TGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCA TGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCA AATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACC TCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGT CCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGT CAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTT TTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCC TCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCA GTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGG CAGGGGGATATGGTGCGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATAT >3390_3390_1_AKAP9-BRAF_AKAP9_chr7_91632549_ENST00000356239_BRAF_chr7_140487384_ENST00000288602_length(amino acids)=1502AA_BP=1116 MFSPAFLAEAMEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCNEMYINSSQRVESTVIPE STIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHE IEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTA ADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKD KLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEM YGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQL EDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEA ELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLV NSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQE ERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYK SKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEV KSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQL ILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSED RNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQ LAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLS GSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDER -------------------------------------------------------------- >3390_3390_2_AKAP9-BRAF_AKAP9_chr7_91632549_ENST00000358100_BRAF_chr7_140487384_ENST00000288602_length(transcript)=4858nt_BP=3579nt GACGAAGATGGCGGCGGCGGCGGCGGTGACGGCGCTTCCCGTGCGGCTGAGGACGATCCGCCAGTGAGCGCGGAGACTGCTTCCACTTCG GGCGGGGGAGCGCCGGACCGAATCGGCTCTCTAGGCCGTGGAGCTTGCCGTCCCACCTCCGTCCAAATCGACCTTTCCTTTCTATCCCCA ACCACCCCTCAACCCCTGTTTTCCCCTGCCTTCCTTGCAGAGGCCATGGAGGACGAGGAGAGACAGAAGAAGCTGGAGGCCGGCAAAGCC AAGATTGAAGAACTCTCTTTAGCTTTTCTTGTCAGACAGCTTGCCCAGTTTCGACAAAGAAAAGCTCAGTCGGATGGGCAGAGTCCTTCC AAGAAGCAGAAAAAAAAGAGAAAAACGTCAAGCAGTAAACATGATGTGTCAGCACACCATGATTTGAATATTGATCAATCACAGTGTAAT GAAATGTACATAAATAGTTCTCAGAGAGTAGAATCAACTGTGATTCCTGAATCTACAATAATGAGAACTCTACATAGTGGAGAAATAACC AGTCATGAGCAGGGCTTCTCTGTGGAACTGGAAAGTGAAATTTCAACCACAGCAGATGACTGCAGTTCAGAGGTAAATGGTTGCAGTTTT GTGATGAGAACAGGAAAGCCTACAAATTTATTAAGGGAAGAAGAATTTGGTGTTGATGATTCTTATTCTGAACAAGGAGCACAAGACAGT CCGACTCATCTAGAGATGATGGAAAGTGAGTTGGCTGGGAAGCAGCATGAGATTGAAGAGCTAAACAGAGAGCTGGAAGAAATGAGGGTT ACCTATGGGACTGAAGGACTGCAGCAGTTACAAGAATTTGAAGCTGCCATTAAACAAAGAGATGGCATTATAACCCAGCTCACTGCTAAT TTACAACAAGCAAGAAGAGAAAAGGATGAGACAATGAGAGAATTTTTAGAGTTGACAGAACAGAGTCAAAAATTACAGATTCAATTTCAG CAATTACAGGCTAGTGAAACTCTGAGAAACAGCACTCATAGTAGCACAGCTGCAGACTTACTACAAGCCAAACAACAGATCCTCACTCAT CAACAGCAGCTTGAAGAACAAGACCACTTATTAGAAGATTATCAGAAAAAGAAAGAAGACTTCACAATGCAAATTAGTTTCTTGCAAGAG AAAATTAAAGTATATGAAATGGAACAAGATAAAAAAGTAGAAAACTCAAATAAAGAAGAAATACAGGAAAAGGAGACAATCATTGAAGAA TTAAACACAAAAATAATAGAAGAAGAAAAGAAAACTCTTGAGCTAAAGGATAAATTAACAACTGCTGATAAATTACTAGGAGAATTACAA GAACAGATTGTGCAAAAGAACCAAGAAATAAAAAACATGAAATTAGAGCTGACTAATTCTAAGCAAAAAGAAAGACAGTCTTCTGAAGAA ATAAAACAGTTAATGGGGACAGTCGAAGAACTTCAGAAGAGAAATCATAAAGACAGCCAGTTCGAAACTGATATAGTACAACGAATGGAA CAAGAAACACAAAGAAAGTTAGAACAACTCCGGGCAGAGCTGGATGAGATGTATGGGCAGCAGATAGTGCAAATGAAACAAGAATTAATA AGACAACACATGGCACAGATGGAGGAAATGAAAACACGGCATAAGGGAGAAATGGAGAATGCTTTAAGGTCATATTCAAATATTACAGTT AATGAAGATCAGATAAAGTTAATGAATGTGGCAATAAATGAACTGAATATAAAATTGCAAGATACTAACTCTCAAAAGGAAAAACTCAAG GAAGAACTAGGACTAATTTTAGAAGAAAAGTGTGCTCTACAGAGACAGCTTGAAGACCTTGTTGAAGAATTGAGCTTTTCAAGGGAACAG ATTCAGAGAGCTAGACAGACAATAGCTGAACAAGAAAGTAAACTTAATGAAGCACATAAGTCCCTTAGTACAGTGGAAGATTTGAAAGCT GAGATTGTTTCTGCATCTGAATCCAGAAAGGAACTAGAATTAAAACATGAAGCAGAAGTTACAAATTACAAGATAAAACTTGAAATGTTA GAAAAAGAAAAGAATGCTGTGTTAGACAGAATGGCTGAATCACAAGAAGCTGAATTAGAGAGGCTGAGAACACAGCTTCTATTTAGTCAC GAAGAAGAGCTTTCCAAACTGAAGGAAGATTTAGAAATTGAACATCGAATAAATATTGAAAAACTTAAAGATAATTTAGGCATTCACTAT AAACAGCAGATAGATGGTTTACAGAATGAAATGAGTCAAAAGATAGAAACCATGCAGTTTGAAAAGGACAATTTGATAACTAAGCAGAAT CAATTAATTTTGGAAATTTCAAAGCTAAAAGATTTACAGCAGTCTCTTGTAAATTCAAAGTCAGAAGAAATGACTCTTCAAATCAATGAA CTTCAAAAAGAAATTGAAATACTCAGACAAGAAGAAAAAGAAAAGGGTACACTTGAACAAGAAGTTCAAGAATTACAACTTAAAACAGAA TTGTTAGAAAAACAGATGAAGGAAAAAGAGAATGATCTTCAAGAAAAATTTGCACAACTTGAAGCAGAGAATAGCATTCTTAAAGATGAA AAGAAAACCCTTGAAGACATGTTGAAAATACATACTCCTGTTAGCCAAGAAGAAAGATTGATTTTCTTAGACTCCATTAAGTCCAAATCC AAAGACTCTGTGTGGGAAAAAGAAATAGAAATACTTATAGAGGAAAATGAGGACCTCAAACAACAATGTATTCAGCTAAATGAAGAGATT GAAAAGCAAAGGAACACTTTTTCATTTGCTGAAAAAAACTTTGAAGTTAACTATCAAGAGTTACAAGAGGAGTATGCTTGCCTTCTCAAA GTAAAAGATGATTTAGAAGACAGTAAAAATAAACAGGAATTAGAGTATAAAAGTAAACTTAAAGCACTTAATGAAGAGCTTCATTTGCAA AGAATAAATCCAACTACAGTGAAAATGAAAAGTTCTGTCTTTGATGAAGACAAAACTTTTGTAGCAGAAACATTGGAAATGGGTGAGGTT GTTGAAAAGGATACAACAGAACTCATGGAAAAACTTGAGGTAACCAAGCGAGAGAAATTAGAGCTGTCACAGAGACTGTCTGATCTTTCT GAACAATTGAAACAGAAACATGGTGAGATTAGTTTTCTAAATGAAGAAGTTAAATCTTTAAAGCAAGAGAAAGAACAAGTTTCATTGAGA TGTAGAGAGCTAGAAATCATTATTAACCACAACAGGGCAGAAAATGTACAGTCATGTGATACTCAAGTAAGCTCTTTATTAGATGGAGTT GTGACCATGACAAGCAGGGGTGCTGAAGGATCAGTTTCTAAAGTAAATAAAAGTTTTGGTGAAGAATCAAAAATAATGGTGGAAGATAAA GTTTCTTTTGAAAATATGACTGTTGGAGAAGAAAGTAAGCAAGAACAGTTGATTTTGGATCACTTACCATCTGTAACAAAGGAATCATCA CTTAGAGCAACTCAACCAAGTGAAAATGATAAACTTCAGAAAGAACTCAATGTACTTAAATCAGAACAGGACTTGATTAGAGACCAAGGA TTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTACAG AAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGACTCGAGT GATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCAT GGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAA ACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTG TATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTA CACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTA GCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATG CAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCA AACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAA GCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTG GCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCT TGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTA >3390_3390_2_AKAP9-BRAF_AKAP9_chr7_91632549_ENST00000358100_BRAF_chr7_140487384_ENST00000288602_length(amino acids)=1514AA_BP=1128 MFSPAFLAEAMEDEERQKKLEAGKAKIEELSLAFLVRQLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCNEMYIN SSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLE MMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQAS ETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKI IEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQR KLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGL ILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKN AVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILE ISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLE DMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDL EDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQ KHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFEN MTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGP QRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVN ILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKS RWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRL -------------------------------------------------------------- >3390_3390_3_AKAP9-BRAF_AKAP9_chr7_91632549_ENST00000359028_BRAF_chr7_140487384_ENST00000288602_length(transcript)=4858nt_BP=3579nt GACGAAGATGGCGGCGGCGGCGGCGGTGACGGCGCTTCCCGTGCGGCTGAGGACGATCCGCCAGTGAGCGCGGAGACTGCTTCCACTTCG GGCGGGGGAGCGCCGGACCGAATCGGCTCTCTAGGCCGTGGAGCTTGCCGTCCCACCTCCGTCCAAATCGACCTTTCCTTTCTATCCCCA ACCACCCCTCAACCCCTGTTTTCCCCTGCCTTCCTTGCAGAGGCCATGGAGGACGAGGAGAGACAGAAGAAGCTGGAGGCCGGCAAAGCC AAGATTGAAGAACTCTCTTTAGCTTTTCTTGTCAGACAGCTTGCCCAGTTTCGACAAAGAAAAGCTCAGTCGGATGGGCAGAGTCCTTCC AAGAAGCAGAAAAAAAAGAGAAAAACGTCAAGCAGTAAACATGATGTGTCAGCACACCATGATTTGAATATTGATCAATCACAGTGTAAT GAAATGTACATAAATAGTTCTCAGAGAGTAGAATCAACTGTGATTCCTGAATCTACAATAATGAGAACTCTACATAGTGGAGAAATAACC AGTCATGAGCAGGGCTTCTCTGTGGAACTGGAAAGTGAAATTTCAACCACAGCAGATGACTGCAGTTCAGAGGTAAATGGTTGCAGTTTT GTGATGAGAACAGGAAAGCCTACAAATTTATTAAGGGAAGAAGAATTTGGTGTTGATGATTCTTATTCTGAACAAGGAGCACAAGACAGT CCGACTCATCTAGAGATGATGGAAAGTGAGTTGGCTGGGAAGCAGCATGAGATTGAAGAGCTAAACAGAGAGCTGGAAGAAATGAGGGTT ACCTATGGGACTGAAGGACTGCAGCAGTTACAAGAATTTGAAGCTGCCATTAAACAAAGAGATGGCATTATAACCCAGCTCACTGCTAAT TTACAACAAGCAAGAAGAGAAAAGGATGAGACAATGAGAGAATTTTTAGAGTTGACAGAACAGAGTCAAAAATTACAGATTCAATTTCAG CAATTACAGGCTAGTGAAACTCTGAGAAACAGCACTCATAGTAGCACAGCTGCAGACTTACTACAAGCCAAACAACAGATCCTCACTCAT CAACAGCAGCTTGAAGAACAAGACCACTTATTAGAAGATTATCAGAAAAAGAAAGAAGACTTCACAATGCAAATTAGTTTCTTGCAAGAG AAAATTAAAGTATATGAAATGGAACAAGATAAAAAAGTAGAAAACTCAAATAAAGAAGAAATACAGGAAAAGGAGACAATCATTGAAGAA TTAAACACAAAAATAATAGAAGAAGAAAAGAAAACTCTTGAGCTAAAGGATAAATTAACAACTGCTGATAAATTACTAGGAGAATTACAA GAACAGATTGTGCAAAAGAACCAAGAAATAAAAAACATGAAATTAGAGCTGACTAATTCTAAGCAAAAAGAAAGACAGTCTTCTGAAGAA ATAAAACAGTTAATGGGGACAGTCGAAGAACTTCAGAAGAGAAATCATAAAGACAGCCAGTTCGAAACTGATATAGTACAACGAATGGAA CAAGAAACACAAAGAAAGTTAGAACAACTCCGGGCAGAGCTGGATGAGATGTATGGGCAGCAGATAGTGCAAATGAAACAAGAATTAATA AGACAACACATGGCACAGATGGAGGAAATGAAAACACGGCATAAGGGAGAAATGGAGAATGCTTTAAGGTCATATTCAAATATTACAGTT AATGAAGATCAGATAAAGTTAATGAATGTGGCAATAAATGAACTGAATATAAAATTGCAAGATACTAACTCTCAAAAGGAAAAACTCAAG GAAGAACTAGGACTAATTTTAGAAGAAAAGTGTGCTCTACAGAGACAGCTTGAAGACCTTGTTGAAGAATTGAGCTTTTCAAGGGAACAG ATTCAGAGAGCTAGACAGACAATAGCTGAACAAGAAAGTAAACTTAATGAAGCACATAAGTCCCTTAGTACAGTGGAAGATTTGAAAGCT GAGATTGTTTCTGCATCTGAATCCAGAAAGGAACTAGAATTAAAACATGAAGCAGAAGTTACAAATTACAAGATAAAACTTGAAATGTTA GAAAAAGAAAAGAATGCTGTGTTAGACAGAATGGCTGAATCACAAGAAGCTGAATTAGAGAGGCTGAGAACACAGCTTCTATTTAGTCAC GAAGAAGAGCTTTCCAAACTGAAGGAAGATTTAGAAATTGAACATCGAATAAATATTGAAAAACTTAAAGATAATTTAGGCATTCACTAT AAACAGCAGATAGATGGTTTACAGAATGAAATGAGTCAAAAGATAGAAACCATGCAGTTTGAAAAGGACAATTTGATAACTAAGCAGAAT CAATTAATTTTGGAAATTTCAAAGCTAAAAGATTTACAGCAGTCTCTTGTAAATTCAAAGTCAGAAGAAATGACTCTTCAAATCAATGAA CTTCAAAAAGAAATTGAAATACTCAGACAAGAAGAAAAAGAAAAGGGTACACTTGAACAAGAAGTTCAAGAATTACAACTTAAAACAGAA TTGTTAGAAAAACAGATGAAGGAAAAAGAGAATGATCTTCAAGAAAAATTTGCACAACTTGAAGCAGAGAATAGCATTCTTAAAGATGAA AAGAAAACCCTTGAAGACATGTTGAAAATACATACTCCTGTTAGCCAAGAAGAAAGATTGATTTTCTTAGACTCCATTAAGTCCAAATCC AAAGACTCTGTGTGGGAAAAAGAAATAGAAATACTTATAGAGGAAAATGAGGACCTCAAACAACAATGTATTCAGCTAAATGAAGAGATT GAAAAGCAAAGGAACACTTTTTCATTTGCTGAAAAAAACTTTGAAGTTAACTATCAAGAGTTACAAGAGGAGTATGCTTGCCTTCTCAAA GTAAAAGATGATTTAGAAGACAGTAAAAATAAACAGGAATTAGAGTATAAAAGTAAACTTAAAGCACTTAATGAAGAGCTTCATTTGCAA AGAATAAATCCAACTACAGTGAAAATGAAAAGTTCTGTCTTTGATGAAGACAAAACTTTTGTAGCAGAAACATTGGAAATGGGTGAGGTT GTTGAAAAGGATACAACAGAACTCATGGAAAAACTTGAGGTAACCAAGCGAGAGAAATTAGAGCTGTCACAGAGACTGTCTGATCTTTCT GAACAATTGAAACAGAAACATGGTGAGATTAGTTTTCTAAATGAAGAAGTTAAATCTTTAAAGCAAGAGAAAGAACAAGTTTCATTGAGA TGTAGAGAGCTAGAAATCATTATTAACCACAACAGGGCAGAAAATGTACAGTCATGTGATACTCAAGTAAGCTCTTTATTAGATGGAGTT GTGACCATGACAAGCAGGGGTGCTGAAGGATCAGTTTCTAAAGTAAATAAAAGTTTTGGTGAAGAATCAAAAATAATGGTGGAAGATAAA GTTTCTTTTGAAAATATGACTGTTGGAGAAGAAAGTAAGCAAGAACAGTTGATTTTGGATCACTTACCATCTGTAACAAAGGAATCATCA CTTAGAGCAACTCAACCAAGTGAAAATGATAAACTTCAGAAAGAACTCAATGTACTTAAATCAGAACAGGACTTGATTAGAGACCAAGGA TTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTACAG AAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGACTCGAGT GATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCAT GGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAA ACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTG TATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTA CACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTA GCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATG CAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCA AACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAA GCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTG GCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCT TGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTA >3390_3390_3_AKAP9-BRAF_AKAP9_chr7_91632549_ENST00000359028_BRAF_chr7_140487384_ENST00000288602_length(amino acids)=1514AA_BP=1128 MFSPAFLAEAMEDEERQKKLEAGKAKIEELSLAFLVRQLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCNEMYIN SSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLE MMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQAS ETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKI IEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQR KLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGL ILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKN AVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILE ISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLE DMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDL EDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQ KHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFEN MTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGP QRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVN ILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKS RWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRL -------------------------------------------------------------- >3390_3390_4_AKAP9-BRAF_AKAP9_chr7_91632550_ENST00000356239_BRAF_chr7_140487386_ENST00000288602_length(transcript)=4830nt_BP=3551nt TACGTGGAGACGAAGATGGCGGCGGCGGCGGCGGTGACGGCGCTTCCCGTGCGGCTGAGGACGATCCGCCAGTGAGCGCGGAGACTGCTT CCACTTCGGGCGGGGGAGCGCCGGACCGAATCGGCTCTCTAGGCCGTGGAGCTTGCCGTCCCACCTCCGTCCAAATCGACCTTTCCTTTC TATCCCCAACCACCCCTCAACCCCTGTTTTCCCCTGCCTTCCTTGCAGAGGCCATGGAGGACGAGGAGAGACAGAAGAAGCTGGAGGCCG GCAAAGCCAAGCTTGCCCAGTTTCGACAAAGAAAAGCTCAGTCGGATGGGCAGAGTCCTTCCAAGAAGCAGAAAAAAAAGAGAAAAACGT CAAGCAGTAAACATGATGTGTCAGCACACCATGATTTGAATATTGATCAATCACAGTGTAATGAAATGTACATAAATAGTTCTCAGAGAG TAGAATCAACTGTGATTCCTGAATCTACAATAATGAGAACTCTACATAGTGGAGAAATAACCAGTCATGAGCAGGGCTTCTCTGTGGAAC TGGAAAGTGAAATTTCAACCACAGCAGATGACTGCAGTTCAGAGGTAAATGGTTGCAGTTTTGTGATGAGAACAGGAAAGCCTACAAATT TATTAAGGGAAGAAGAATTTGGTGTTGATGATTCTTATTCTGAACAAGGAGCACAAGACAGTCCGACTCATCTAGAGATGATGGAAAGTG AGTTGGCTGGGAAGCAGCATGAGATTGAAGAGCTAAACAGAGAGCTGGAAGAAATGAGGGTTACCTATGGGACTGAAGGACTGCAGCAGT TACAAGAATTTGAAGCTGCCATTAAACAAAGAGATGGCATTATAACCCAGCTCACTGCTAATTTACAACAAGCAAGAAGAGAAAAGGATG AGACAATGAGAGAATTTTTAGAGTTGACAGAACAGAGTCAAAAATTACAGATTCAATTTCAGCAATTACAGGCTAGTGAAACTCTGAGAA ACAGCACTCATAGTAGCACAGCTGCAGACTTACTACAAGCCAAACAACAGATCCTCACTCATCAACAGCAGCTTGAAGAACAAGACCACT TATTAGAAGATTATCAGAAAAAGAAAGAAGACTTCACAATGCAAATTAGTTTCTTGCAAGAGAAAATTAAAGTATATGAAATGGAACAAG ATAAAAAAGTAGAAAACTCAAATAAAGAAGAAATACAGGAAAAGGAGACAATCATTGAAGAATTAAACACAAAAATAATAGAAGAAGAAA AGAAAACTCTTGAGCTAAAGGATAAATTAACAACTGCTGATAAATTACTAGGAGAATTACAAGAACAGATTGTGCAAAAGAACCAAGAAA TAAAAAACATGAAATTAGAGCTGACTAATTCTAAGCAAAAAGAAAGACAGTCTTCTGAAGAAATAAAACAGTTAATGGGGACAGTCGAAG AACTTCAGAAGAGAAATCATAAAGACAGCCAGTTCGAAACTGATATAGTACAACGAATGGAACAAGAAACACAAAGAAAGTTAGAACAAC TCCGGGCAGAGCTGGATGAGATGTATGGGCAGCAGATAGTGCAAATGAAACAAGAATTAATAAGACAACACATGGCACAGATGGAGGAAA TGAAAACACGGCATAAGGGAGAAATGGAGAATGCTTTAAGGTCATATTCAAATATTACAGTTAATGAAGATCAGATAAAGTTAATGAATG TGGCAATAAATGAACTGAATATAAAATTGCAAGATACTAACTCTCAAAAGGAAAAACTCAAGGAAGAACTAGGACTAATTTTAGAAGAAA AGTGTGCTCTACAGAGACAGCTTGAAGACCTTGTTGAAGAATTGAGCTTTTCAAGGGAACAGATTCAGAGAGCTAGACAGACAATAGCTG AACAAGAAAGTAAACTTAATGAAGCACATAAGTCCCTTAGTACAGTGGAAGATTTGAAAGCTGAGATTGTTTCTGCATCTGAATCCAGAA AGGAACTAGAATTAAAACATGAAGCAGAAGTTACAAATTACAAGATAAAACTTGAAATGTTAGAAAAAGAAAAGAATGCTGTGTTAGACA GAATGGCTGAATCACAAGAAGCTGAATTAGAGAGGCTGAGAACACAGCTTCTATTTAGTCACGAAGAAGAGCTTTCCAAACTGAAGGAAG ATTTAGAAATTGAACATCGAATAAATATTGAAAAACTTAAAGATAATTTAGGCATTCACTATAAACAGCAGATAGATGGTTTACAGAATG AAATGAGTCAAAAGATAGAAACCATGCAGTTTGAAAAGGACAATTTGATAACTAAGCAGAATCAATTAATTTTGGAAATTTCAAAGCTAA AAGATTTACAGCAGTCTCTTGTAAATTCAAAGTCAGAAGAAATGACTCTTCAAATCAATGAACTTCAAAAAGAAATTGAAATACTCAGAC AAGAAGAAAAAGAAAAGGGTACACTTGAACAAGAAGTTCAAGAATTACAACTTAAAACAGAATTGTTAGAAAAACAGATGAAGGAAAAAG AGAATGATCTTCAAGAAAAATTTGCACAACTTGAAGCAGAGAATAGCATTCTTAAAGATGAAAAGAAAACCCTTGAAGACATGTTGAAAA TACATACTCCTGTTAGCCAAGAAGAAAGATTGATTTTCTTAGACTCCATTAAGTCCAAATCCAAAGACTCTGTGTGGGAAAAAGAAATAG AAATACTTATAGAGGAAAATGAGGACCTCAAACAACAATGTATTCAGCTAAATGAAGAGATTGAAAAGCAAAGGAACACTTTTTCATTTG CTGAAAAAAACTTTGAAGTTAACTATCAAGAGTTACAAGAGGAGTATGCTTGCCTTCTCAAAGTAAAAGATGATTTAGAAGACAGTAAAA ATAAACAGGAATTAGAGTATAAAAGTAAACTTAAAGCACTTAATGAAGAGCTTCATTTGCAAAGAATAAATCCAACTACAGTGAAAATGA AAAGTTCTGTCTTTGATGAAGACAAAACTTTTGTAGCAGAAACATTGGAAATGGGTGAGGTTGTTGAAAAGGATACAACAGAACTCATGG AAAAACTTGAGGTAACCAAGCGAGAGAAATTAGAGCTGTCACAGAGACTGTCTGATCTTTCTGAACAATTGAAACAGAAACATGGTGAGA TTAGTTTTCTAAATGAAGAAGTTAAATCTTTAAAGCAAGAGAAAGAACAAGTTTCATTGAGATGTAGAGAGCTAGAAATCATTATTAACC ACAACAGGGCAGAAAATGTACAGTCATGTGATACTCAAGTAAGCTCTTTATTAGATGGAGTTGTGACCATGACAAGCAGGGGTGCTGAAG GATCAGTTTCTAAAGTAAATAAAAGTTTTGGTGAAGAATCAAAAATAATGGTGGAAGATAAAGTTTCTTTTGAAAATATGACTGTTGGAG AAGAAAGTAAGCAAGAACAGTTGATTTTGGATCACTTACCATCTGTAACAAAGGAATCATCACTTAGAGCAACTCAACCAAGTGAAAATG ATAAACTTCAGAAAGAACTCAATGTACTTAAATCAGAACAGGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAG GTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGA AGTCATCTTCATCCTCAGAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGA TTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATG TGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCA TGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCA AATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACC TCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGT CCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGT CAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTT TTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCC TCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCA GTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGG CAGGGGGATATGGTGCGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATAT >3390_3390_4_AKAP9-BRAF_AKAP9_chr7_91632550_ENST00000356239_BRAF_chr7_140487386_ENST00000288602_length(amino acids)=1502AA_BP=1116 MFSPAFLAEAMEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCNEMYINSSQRVESTVIPE STIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHE IEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTA ADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKD KLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEM YGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQL EDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEA ELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLV NSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQE ERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYK SKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEV KSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQL ILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSED RNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQ LAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLS GSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDER -------------------------------------------------------------- >3390_3390_5_AKAP9-BRAF_AKAP9_chr7_91632550_ENST00000358100_BRAF_chr7_140487386_ENST00000288602_length(transcript)=4858nt_BP=3579nt GACGAAGATGGCGGCGGCGGCGGCGGTGACGGCGCTTCCCGTGCGGCTGAGGACGATCCGCCAGTGAGCGCGGAGACTGCTTCCACTTCG GGCGGGGGAGCGCCGGACCGAATCGGCTCTCTAGGCCGTGGAGCTTGCCGTCCCACCTCCGTCCAAATCGACCTTTCCTTTCTATCCCCA ACCACCCCTCAACCCCTGTTTTCCCCTGCCTTCCTTGCAGAGGCCATGGAGGACGAGGAGAGACAGAAGAAGCTGGAGGCCGGCAAAGCC AAGATTGAAGAACTCTCTTTAGCTTTTCTTGTCAGACAGCTTGCCCAGTTTCGACAAAGAAAAGCTCAGTCGGATGGGCAGAGTCCTTCC AAGAAGCAGAAAAAAAAGAGAAAAACGTCAAGCAGTAAACATGATGTGTCAGCACACCATGATTTGAATATTGATCAATCACAGTGTAAT GAAATGTACATAAATAGTTCTCAGAGAGTAGAATCAACTGTGATTCCTGAATCTACAATAATGAGAACTCTACATAGTGGAGAAATAACC AGTCATGAGCAGGGCTTCTCTGTGGAACTGGAAAGTGAAATTTCAACCACAGCAGATGACTGCAGTTCAGAGGTAAATGGTTGCAGTTTT GTGATGAGAACAGGAAAGCCTACAAATTTATTAAGGGAAGAAGAATTTGGTGTTGATGATTCTTATTCTGAACAAGGAGCACAAGACAGT CCGACTCATCTAGAGATGATGGAAAGTGAGTTGGCTGGGAAGCAGCATGAGATTGAAGAGCTAAACAGAGAGCTGGAAGAAATGAGGGTT ACCTATGGGACTGAAGGACTGCAGCAGTTACAAGAATTTGAAGCTGCCATTAAACAAAGAGATGGCATTATAACCCAGCTCACTGCTAAT TTACAACAAGCAAGAAGAGAAAAGGATGAGACAATGAGAGAATTTTTAGAGTTGACAGAACAGAGTCAAAAATTACAGATTCAATTTCAG CAATTACAGGCTAGTGAAACTCTGAGAAACAGCACTCATAGTAGCACAGCTGCAGACTTACTACAAGCCAAACAACAGATCCTCACTCAT CAACAGCAGCTTGAAGAACAAGACCACTTATTAGAAGATTATCAGAAAAAGAAAGAAGACTTCACAATGCAAATTAGTTTCTTGCAAGAG AAAATTAAAGTATATGAAATGGAACAAGATAAAAAAGTAGAAAACTCAAATAAAGAAGAAATACAGGAAAAGGAGACAATCATTGAAGAA TTAAACACAAAAATAATAGAAGAAGAAAAGAAAACTCTTGAGCTAAAGGATAAATTAACAACTGCTGATAAATTACTAGGAGAATTACAA GAACAGATTGTGCAAAAGAACCAAGAAATAAAAAACATGAAATTAGAGCTGACTAATTCTAAGCAAAAAGAAAGACAGTCTTCTGAAGAA ATAAAACAGTTAATGGGGACAGTCGAAGAACTTCAGAAGAGAAATCATAAAGACAGCCAGTTCGAAACTGATATAGTACAACGAATGGAA CAAGAAACACAAAGAAAGTTAGAACAACTCCGGGCAGAGCTGGATGAGATGTATGGGCAGCAGATAGTGCAAATGAAACAAGAATTAATA AGACAACACATGGCACAGATGGAGGAAATGAAAACACGGCATAAGGGAGAAATGGAGAATGCTTTAAGGTCATATTCAAATATTACAGTT AATGAAGATCAGATAAAGTTAATGAATGTGGCAATAAATGAACTGAATATAAAATTGCAAGATACTAACTCTCAAAAGGAAAAACTCAAG GAAGAACTAGGACTAATTTTAGAAGAAAAGTGTGCTCTACAGAGACAGCTTGAAGACCTTGTTGAAGAATTGAGCTTTTCAAGGGAACAG ATTCAGAGAGCTAGACAGACAATAGCTGAACAAGAAAGTAAACTTAATGAAGCACATAAGTCCCTTAGTACAGTGGAAGATTTGAAAGCT GAGATTGTTTCTGCATCTGAATCCAGAAAGGAACTAGAATTAAAACATGAAGCAGAAGTTACAAATTACAAGATAAAACTTGAAATGTTA GAAAAAGAAAAGAATGCTGTGTTAGACAGAATGGCTGAATCACAAGAAGCTGAATTAGAGAGGCTGAGAACACAGCTTCTATTTAGTCAC GAAGAAGAGCTTTCCAAACTGAAGGAAGATTTAGAAATTGAACATCGAATAAATATTGAAAAACTTAAAGATAATTTAGGCATTCACTAT AAACAGCAGATAGATGGTTTACAGAATGAAATGAGTCAAAAGATAGAAACCATGCAGTTTGAAAAGGACAATTTGATAACTAAGCAGAAT CAATTAATTTTGGAAATTTCAAAGCTAAAAGATTTACAGCAGTCTCTTGTAAATTCAAAGTCAGAAGAAATGACTCTTCAAATCAATGAA CTTCAAAAAGAAATTGAAATACTCAGACAAGAAGAAAAAGAAAAGGGTACACTTGAACAAGAAGTTCAAGAATTACAACTTAAAACAGAA TTGTTAGAAAAACAGATGAAGGAAAAAGAGAATGATCTTCAAGAAAAATTTGCACAACTTGAAGCAGAGAATAGCATTCTTAAAGATGAA AAGAAAACCCTTGAAGACATGTTGAAAATACATACTCCTGTTAGCCAAGAAGAAAGATTGATTTTCTTAGACTCCATTAAGTCCAAATCC AAAGACTCTGTGTGGGAAAAAGAAATAGAAATACTTATAGAGGAAAATGAGGACCTCAAACAACAATGTATTCAGCTAAATGAAGAGATT GAAAAGCAAAGGAACACTTTTTCATTTGCTGAAAAAAACTTTGAAGTTAACTATCAAGAGTTACAAGAGGAGTATGCTTGCCTTCTCAAA GTAAAAGATGATTTAGAAGACAGTAAAAATAAACAGGAATTAGAGTATAAAAGTAAACTTAAAGCACTTAATGAAGAGCTTCATTTGCAA AGAATAAATCCAACTACAGTGAAAATGAAAAGTTCTGTCTTTGATGAAGACAAAACTTTTGTAGCAGAAACATTGGAAATGGGTGAGGTT GTTGAAAAGGATACAACAGAACTCATGGAAAAACTTGAGGTAACCAAGCGAGAGAAATTAGAGCTGTCACAGAGACTGTCTGATCTTTCT GAACAATTGAAACAGAAACATGGTGAGATTAGTTTTCTAAATGAAGAAGTTAAATCTTTAAAGCAAGAGAAAGAACAAGTTTCATTGAGA TGTAGAGAGCTAGAAATCATTATTAACCACAACAGGGCAGAAAATGTACAGTCATGTGATACTCAAGTAAGCTCTTTATTAGATGGAGTT GTGACCATGACAAGCAGGGGTGCTGAAGGATCAGTTTCTAAAGTAAATAAAAGTTTTGGTGAAGAATCAAAAATAATGGTGGAAGATAAA GTTTCTTTTGAAAATATGACTGTTGGAGAAGAAAGTAAGCAAGAACAGTTGATTTTGGATCACTTACCATCTGTAACAAAGGAATCATCA CTTAGAGCAACTCAACCAAGTGAAAATGATAAACTTCAGAAAGAACTCAATGTACTTAAATCAGAACAGGACTTGATTAGAGACCAAGGA TTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTACAG AAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGACTCGAGT GATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCAT GGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAA ACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTG TATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTA CACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTA GCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATG CAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCA AACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAA GCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTG GCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCT TGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTA >3390_3390_5_AKAP9-BRAF_AKAP9_chr7_91632550_ENST00000358100_BRAF_chr7_140487386_ENST00000288602_length(amino acids)=1514AA_BP=1128 MFSPAFLAEAMEDEERQKKLEAGKAKIEELSLAFLVRQLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCNEMYIN SSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLE MMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQAS ETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKI IEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQR KLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGL ILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKN AVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILE ISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLE DMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDL EDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQ KHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFEN MTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGP QRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVN ILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKS RWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRL -------------------------------------------------------------- >3390_3390_6_AKAP9-BRAF_AKAP9_chr7_91632550_ENST00000359028_BRAF_chr7_140487386_ENST00000288602_length(transcript)=4858nt_BP=3579nt GACGAAGATGGCGGCGGCGGCGGCGGTGACGGCGCTTCCCGTGCGGCTGAGGACGATCCGCCAGTGAGCGCGGAGACTGCTTCCACTTCG GGCGGGGGAGCGCCGGACCGAATCGGCTCTCTAGGCCGTGGAGCTTGCCGTCCCACCTCCGTCCAAATCGACCTTTCCTTTCTATCCCCA ACCACCCCTCAACCCCTGTTTTCCCCTGCCTTCCTTGCAGAGGCCATGGAGGACGAGGAGAGACAGAAGAAGCTGGAGGCCGGCAAAGCC AAGATTGAAGAACTCTCTTTAGCTTTTCTTGTCAGACAGCTTGCCCAGTTTCGACAAAGAAAAGCTCAGTCGGATGGGCAGAGTCCTTCC AAGAAGCAGAAAAAAAAGAGAAAAACGTCAAGCAGTAAACATGATGTGTCAGCACACCATGATTTGAATATTGATCAATCACAGTGTAAT GAAATGTACATAAATAGTTCTCAGAGAGTAGAATCAACTGTGATTCCTGAATCTACAATAATGAGAACTCTACATAGTGGAGAAATAACC AGTCATGAGCAGGGCTTCTCTGTGGAACTGGAAAGTGAAATTTCAACCACAGCAGATGACTGCAGTTCAGAGGTAAATGGTTGCAGTTTT GTGATGAGAACAGGAAAGCCTACAAATTTATTAAGGGAAGAAGAATTTGGTGTTGATGATTCTTATTCTGAACAAGGAGCACAAGACAGT CCGACTCATCTAGAGATGATGGAAAGTGAGTTGGCTGGGAAGCAGCATGAGATTGAAGAGCTAAACAGAGAGCTGGAAGAAATGAGGGTT ACCTATGGGACTGAAGGACTGCAGCAGTTACAAGAATTTGAAGCTGCCATTAAACAAAGAGATGGCATTATAACCCAGCTCACTGCTAAT TTACAACAAGCAAGAAGAGAAAAGGATGAGACAATGAGAGAATTTTTAGAGTTGACAGAACAGAGTCAAAAATTACAGATTCAATTTCAG CAATTACAGGCTAGTGAAACTCTGAGAAACAGCACTCATAGTAGCACAGCTGCAGACTTACTACAAGCCAAACAACAGATCCTCACTCAT CAACAGCAGCTTGAAGAACAAGACCACTTATTAGAAGATTATCAGAAAAAGAAAGAAGACTTCACAATGCAAATTAGTTTCTTGCAAGAG AAAATTAAAGTATATGAAATGGAACAAGATAAAAAAGTAGAAAACTCAAATAAAGAAGAAATACAGGAAAAGGAGACAATCATTGAAGAA TTAAACACAAAAATAATAGAAGAAGAAAAGAAAACTCTTGAGCTAAAGGATAAATTAACAACTGCTGATAAATTACTAGGAGAATTACAA GAACAGATTGTGCAAAAGAACCAAGAAATAAAAAACATGAAATTAGAGCTGACTAATTCTAAGCAAAAAGAAAGACAGTCTTCTGAAGAA ATAAAACAGTTAATGGGGACAGTCGAAGAACTTCAGAAGAGAAATCATAAAGACAGCCAGTTCGAAACTGATATAGTACAACGAATGGAA CAAGAAACACAAAGAAAGTTAGAACAACTCCGGGCAGAGCTGGATGAGATGTATGGGCAGCAGATAGTGCAAATGAAACAAGAATTAATA AGACAACACATGGCACAGATGGAGGAAATGAAAACACGGCATAAGGGAGAAATGGAGAATGCTTTAAGGTCATATTCAAATATTACAGTT AATGAAGATCAGATAAAGTTAATGAATGTGGCAATAAATGAACTGAATATAAAATTGCAAGATACTAACTCTCAAAAGGAAAAACTCAAG GAAGAACTAGGACTAATTTTAGAAGAAAAGTGTGCTCTACAGAGACAGCTTGAAGACCTTGTTGAAGAATTGAGCTTTTCAAGGGAACAG ATTCAGAGAGCTAGACAGACAATAGCTGAACAAGAAAGTAAACTTAATGAAGCACATAAGTCCCTTAGTACAGTGGAAGATTTGAAAGCT GAGATTGTTTCTGCATCTGAATCCAGAAAGGAACTAGAATTAAAACATGAAGCAGAAGTTACAAATTACAAGATAAAACTTGAAATGTTA GAAAAAGAAAAGAATGCTGTGTTAGACAGAATGGCTGAATCACAAGAAGCTGAATTAGAGAGGCTGAGAACACAGCTTCTATTTAGTCAC GAAGAAGAGCTTTCCAAACTGAAGGAAGATTTAGAAATTGAACATCGAATAAATATTGAAAAACTTAAAGATAATTTAGGCATTCACTAT AAACAGCAGATAGATGGTTTACAGAATGAAATGAGTCAAAAGATAGAAACCATGCAGTTTGAAAAGGACAATTTGATAACTAAGCAGAAT CAATTAATTTTGGAAATTTCAAAGCTAAAAGATTTACAGCAGTCTCTTGTAAATTCAAAGTCAGAAGAAATGACTCTTCAAATCAATGAA CTTCAAAAAGAAATTGAAATACTCAGACAAGAAGAAAAAGAAAAGGGTACACTTGAACAAGAAGTTCAAGAATTACAACTTAAAACAGAA TTGTTAGAAAAACAGATGAAGGAAAAAGAGAATGATCTTCAAGAAAAATTTGCACAACTTGAAGCAGAGAATAGCATTCTTAAAGATGAA AAGAAAACCCTTGAAGACATGTTGAAAATACATACTCCTGTTAGCCAAGAAGAAAGATTGATTTTCTTAGACTCCATTAAGTCCAAATCC AAAGACTCTGTGTGGGAAAAAGAAATAGAAATACTTATAGAGGAAAATGAGGACCTCAAACAACAATGTATTCAGCTAAATGAAGAGATT GAAAAGCAAAGGAACACTTTTTCATTTGCTGAAAAAAACTTTGAAGTTAACTATCAAGAGTTACAAGAGGAGTATGCTTGCCTTCTCAAA GTAAAAGATGATTTAGAAGACAGTAAAAATAAACAGGAATTAGAGTATAAAAGTAAACTTAAAGCACTTAATGAAGAGCTTCATTTGCAA AGAATAAATCCAACTACAGTGAAAATGAAAAGTTCTGTCTTTGATGAAGACAAAACTTTTGTAGCAGAAACATTGGAAATGGGTGAGGTT GTTGAAAAGGATACAACAGAACTCATGGAAAAACTTGAGGTAACCAAGCGAGAGAAATTAGAGCTGTCACAGAGACTGTCTGATCTTTCT GAACAATTGAAACAGAAACATGGTGAGATTAGTTTTCTAAATGAAGAAGTTAAATCTTTAAAGCAAGAGAAAGAACAAGTTTCATTGAGA TGTAGAGAGCTAGAAATCATTATTAACCACAACAGGGCAGAAAATGTACAGTCATGTGATACTCAAGTAAGCTCTTTATTAGATGGAGTT GTGACCATGACAAGCAGGGGTGCTGAAGGATCAGTTTCTAAAGTAAATAAAAGTTTTGGTGAAGAATCAAAAATAATGGTGGAAGATAAA GTTTCTTTTGAAAATATGACTGTTGGAGAAGAAAGTAAGCAAGAACAGTTGATTTTGGATCACTTACCATCTGTAACAAAGGAATCATCA CTTAGAGCAACTCAACCAAGTGAAAATGATAAACTTCAGAAAGAACTCAATGTACTTAAATCAGAACAGGACTTGATTAGAGACCAAGGA TTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTACAG AAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGACTCGAGT GATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCAT GGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAA ACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTG TATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTA CACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTA GCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATG CAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCA AACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAA GCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTG GCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCT TGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTA >3390_3390_6_AKAP9-BRAF_AKAP9_chr7_91632550_ENST00000359028_BRAF_chr7_140487386_ENST00000288602_length(amino acids)=1514AA_BP=1128 MFSPAFLAEAMEDEERQKKLEAGKAKIEELSLAFLVRQLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCNEMYIN SSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLE MMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQAS ETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKI IEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQR KLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGL ILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKN AVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILE ISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLE DMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDL EDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQ KHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFEN MTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGP QRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVN ILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKS RWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRL -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for AKAP9-BRAF |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for AKAP9-BRAF |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for AKAP9-BRAF |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |