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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:GOLIM4-MECOM (FusionGDB2 ID:33948)

Fusion Gene Summary for GOLIM4-MECOM

check button Fusion gene summary
Fusion gene informationFusion gene name: GOLIM4-MECOM
Fusion gene ID: 33948
HgeneTgene
Gene symbol

GOLIM4

MECOM

Gene ID

27333

2122

Gene namegolgi integral membrane protein 4MDS1 and EVI1 complex locus
SynonymsGIMPC|GOLPH4|GPP130|P138AML1-EVI-1|EVI1|KMT8E|MDS1|MDS1-EVI1|PRDM3|RUSAT2
Cytomap

3q26.2

3q26.2

Type of geneprotein-codingprotein-coding
DescriptionGolgi integral membrane protein 4130 kDa golgi-localized phosphoproteincis Golgi-localized calcium-binding proteingolgi integral membrane protein, cisgolgi phosphoprotein 4golgi phosphoprotein of 130 kDagolgi-localized phosphoprotein of 130 kDatypehistone-lysine N-methyltransferase MECOMAML1-EVI-1 fusion proteinMDS1 and EVI1 complex locus protein EVI1MDS1 and EVI1 complex locus protein MDS1PR domain 3ecotropic virus integration site 1 protein homologmyelodysplasia syndrome-associated protein
Modification date2020031320200313
UniProtAcc

O00461

Q03112

Ensembl transtripts involved in fusion geneENST00000309027, ENST00000470487, 
ENST00000392736, ENST00000433243, 
ENST00000464456, ENST00000468789, 
ENST00000472280, ENST00000494292, 
ENST00000460814, ENST00000485957, 
ENST00000264674, 
Fusion gene scores* DoF score14 X 11 X 10=154018 X 18 X 11=3564
# samples 1823
** MAII scorelog2(18/1540*10)=-3.09686153925259
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/3564*10)=-3.95379157057755
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GOLIM4 [Title/Abstract] AND MECOM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGOLIM4(167742314)-MECOM(168861620), # samples:3
MECOM(169098975)-GOLIM4(167728611), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMECOM

GO:0045892

negative regulation of transcription, DNA-templated

10856240|11568182

TgeneMECOM

GO:0045893

positive regulation of transcription, DNA-templated

11568182|19767769

TgeneMECOM

GO:0051726

regulation of cell cycle

11568182


check buttonFusion gene breakpoints across GOLIM4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MECOM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-W3-A828-06AGOLIM4chr3

167742314

-MECOMchr3

168861620

-


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Fusion Gene ORF analysis for GOLIM4-MECOM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000309027ENST00000392736GOLIM4chr3

167742314

-MECOMchr3

168861620

-
5CDS-5UTRENST00000309027ENST00000433243GOLIM4chr3

167742314

-MECOMchr3

168861620

-
5CDS-5UTRENST00000309027ENST00000464456GOLIM4chr3

167742314

-MECOMchr3

168861620

-
5CDS-5UTRENST00000309027ENST00000468789GOLIM4chr3

167742314

-MECOMchr3

168861620

-
5CDS-5UTRENST00000309027ENST00000472280GOLIM4chr3

167742314

-MECOMchr3

168861620

-
5CDS-5UTRENST00000309027ENST00000494292GOLIM4chr3

167742314

-MECOMchr3

168861620

-
5CDS-5UTRENST00000470487ENST00000392736GOLIM4chr3

167742314

-MECOMchr3

168861620

-
5CDS-5UTRENST00000470487ENST00000433243GOLIM4chr3

167742314

-MECOMchr3

168861620

-
5CDS-5UTRENST00000470487ENST00000464456GOLIM4chr3

167742314

-MECOMchr3

168861620

-
5CDS-5UTRENST00000470487ENST00000468789GOLIM4chr3

167742314

-MECOMchr3

168861620

-
5CDS-5UTRENST00000470487ENST00000472280GOLIM4chr3

167742314

-MECOMchr3

168861620

-
5CDS-5UTRENST00000470487ENST00000494292GOLIM4chr3

167742314

-MECOMchr3

168861620

-
5CDS-intronENST00000309027ENST00000460814GOLIM4chr3

167742314

-MECOMchr3

168861620

-
5CDS-intronENST00000309027ENST00000485957GOLIM4chr3

167742314

-MECOMchr3

168861620

-
5CDS-intronENST00000470487ENST00000460814GOLIM4chr3

167742314

-MECOMchr3

168861620

-
5CDS-intronENST00000470487ENST00000485957GOLIM4chr3

167742314

-MECOMchr3

168861620

-
In-frameENST00000309027ENST00000264674GOLIM4chr3

167742314

-MECOMchr3

168861620

-
In-frameENST00000470487ENST00000264674GOLIM4chr3

167742314

-MECOMchr3

168861620

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000470487GOLIM4chr3167742314-ENST00000264674MECOMchr3168861620-7308255067258971741
ENST00000309027GOLIM4chr3167742314-ENST00000264674MECOMchr3168861620-659318354151821713

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000470487ENST00000264674GOLIM4chr3167742314-MECOMchr3168861620-0.0014632350.9985368
ENST00000309027ENST00000264674GOLIM4chr3167742314-MECOMchr3168861620-0.0006864880.9993135

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Fusion Genomic Features for GOLIM4-MECOM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GOLIM4-MECOM


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:167742314/chr3:168861620)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GOLIM4

O00461

MECOM

Q03112

FUNCTION: Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi. {ECO:0000269|PubMed:15331763}.FUNCTION: [Isoform 1]: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. {ECO:0000269|PubMed:10856240, ECO:0000269|PubMed:11568182, ECO:0000269|PubMed:15897867, ECO:0000269|PubMed:16462766, ECO:0000269|PubMed:19767769, ECO:0000269|PubMed:9665135}.; FUNCTION: [Isoform 7]: Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation. {ECO:0000250|UniProtKB:P14404}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGOLIM4chr3:167742314chr3:168861620ENST00000470487-141635_244620697.0Coiled coilOntology_term=ECO:0000255
HgeneGOLIM4chr3:167742314chr3:168861620ENST00000470487-1416404_513620697.0Compositional biasNote=Gln-rich
HgeneGOLIM4chr3:167742314chr3:168861620ENST00000470487-1416176_248620697.0RegionNote=Golgi targeting
HgeneGOLIM4chr3:167742314chr3:168861620ENST00000470487-141638_107620697.0RegionNote=Golgi targeting
HgeneGOLIM4chr3:167742314chr3:168861620ENST00000470487-141680_175620697.0RegionNote=Endosome targeting
HgeneGOLIM4chr3:167742314chr3:168861620ENST00000470487-14162_12620697.0Topological domainCytoplasmic
HgeneGOLIM4chr3:167742314chr3:168861620ENST00000470487-141613_33620697.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneMECOMchr3:167742314chr3:168861620ENST000002646741171065_111611117.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMECOMchr3:167742314chr3:168861620ENST000003927360161065_111601052.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMECOMchr3:167742314chr3:168861620ENST000004332431171065_111601053.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMECOMchr3:167742314chr3:168861620ENST000004644560151065_111601043.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMECOMchr3:167742314chr3:168861620ENST000004687890161065_111601052.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMECOMchr3:167742314chr3:168861620ENST000004722800161065_111601053.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMECOMchr3:167742314chr3:168861620ENST0000026467411778_19011117.0DomainSET
TgeneMECOMchr3:167742314chr3:168861620ENST0000039273601678_19001052.0DomainSET
TgeneMECOMchr3:167742314chr3:168861620ENST0000043324311778_19001053.0DomainSET
TgeneMECOMchr3:167742314chr3:168861620ENST0000046445601578_19001043.0DomainSET
TgeneMECOMchr3:167742314chr3:168861620ENST0000046878901678_19001052.0DomainSET
TgeneMECOMchr3:167742314chr3:168861620ENST0000047228001678_19001053.0DomainSET
TgeneMECOMchr3:167742314chr3:168861620ENST00000264674117609_62211117.0MotifNuclear localization signal
TgeneMECOMchr3:167742314chr3:168861620ENST00000264674117741_74511117.0MotifCTBP-binding motif 1
TgeneMECOMchr3:167742314chr3:168861620ENST00000264674117772_77611117.0MotifCTBP-binding motif 2
TgeneMECOMchr3:167742314chr3:168861620ENST00000392736016609_62201052.0MotifNuclear localization signal
TgeneMECOMchr3:167742314chr3:168861620ENST00000392736016741_74501052.0MotifCTBP-binding motif 1
TgeneMECOMchr3:167742314chr3:168861620ENST00000392736016772_77601052.0MotifCTBP-binding motif 2
TgeneMECOMchr3:167742314chr3:168861620ENST00000433243117609_62201053.0MotifNuclear localization signal
TgeneMECOMchr3:167742314chr3:168861620ENST00000433243117741_74501053.0MotifCTBP-binding motif 1
TgeneMECOMchr3:167742314chr3:168861620ENST00000433243117772_77601053.0MotifCTBP-binding motif 2
TgeneMECOMchr3:167742314chr3:168861620ENST00000464456015609_62201043.0MotifNuclear localization signal
TgeneMECOMchr3:167742314chr3:168861620ENST00000464456015741_74501043.0MotifCTBP-binding motif 1
TgeneMECOMchr3:167742314chr3:168861620ENST00000464456015772_77601043.0MotifCTBP-binding motif 2
TgeneMECOMchr3:167742314chr3:168861620ENST00000468789016609_62201052.0MotifNuclear localization signal
TgeneMECOMchr3:167742314chr3:168861620ENST00000468789016741_74501052.0MotifCTBP-binding motif 1
TgeneMECOMchr3:167742314chr3:168861620ENST00000468789016772_77601052.0MotifCTBP-binding motif 2
TgeneMECOMchr3:167742314chr3:168861620ENST00000472280016609_62201053.0MotifNuclear localization signal
TgeneMECOMchr3:167742314chr3:168861620ENST00000472280016741_74501053.0MotifCTBP-binding motif 1
TgeneMECOMchr3:167742314chr3:168861620ENST00000472280016772_77601053.0MotifCTBP-binding motif 2
TgeneMECOMchr3:167742314chr3:168861620ENST00000264674117209_23611117.0Zinc fingerC2H2-type 1
TgeneMECOMchr3:167742314chr3:168861620ENST00000264674117263_28511117.0Zinc fingerC2H2-type 2
TgeneMECOMchr3:167742314chr3:168861620ENST00000264674117291_31311117.0Zinc fingerC2H2-type 3
TgeneMECOMchr3:167742314chr3:168861620ENST00000264674117319_34211117.0Zinc fingerC2H2-type 4
TgeneMECOMchr3:167742314chr3:168861620ENST00000264674117348_37011117.0Zinc fingerC2H2-type 5
TgeneMECOMchr3:167742314chr3:168861620ENST00000264674117376_39811117.0Zinc fingerC2H2-type 6
TgeneMECOMchr3:167742314chr3:168861620ENST00000264674117405_42711117.0Zinc fingerC2H2-type 7%3B atypical
TgeneMECOMchr3:167742314chr3:168861620ENST00000264674117912_93411117.0Zinc fingerC2H2-type 8
TgeneMECOMchr3:167742314chr3:168861620ENST00000264674117940_96311117.0Zinc fingerC2H2-type 9
TgeneMECOMchr3:167742314chr3:168861620ENST00000264674117969_99111117.0Zinc fingerC2H2-type 10
TgeneMECOMchr3:167742314chr3:168861620ENST00000392736016209_23601052.0Zinc fingerC2H2-type 1
TgeneMECOMchr3:167742314chr3:168861620ENST00000392736016263_28501052.0Zinc fingerC2H2-type 2
TgeneMECOMchr3:167742314chr3:168861620ENST00000392736016291_31301052.0Zinc fingerC2H2-type 3
TgeneMECOMchr3:167742314chr3:168861620ENST00000392736016319_34201052.0Zinc fingerC2H2-type 4
TgeneMECOMchr3:167742314chr3:168861620ENST00000392736016348_37001052.0Zinc fingerC2H2-type 5
TgeneMECOMchr3:167742314chr3:168861620ENST00000392736016376_39801052.0Zinc fingerC2H2-type 6
TgeneMECOMchr3:167742314chr3:168861620ENST00000392736016405_42701052.0Zinc fingerC2H2-type 7%3B atypical
TgeneMECOMchr3:167742314chr3:168861620ENST00000392736016912_93401052.0Zinc fingerC2H2-type 8
TgeneMECOMchr3:167742314chr3:168861620ENST00000392736016940_96301052.0Zinc fingerC2H2-type 9
TgeneMECOMchr3:167742314chr3:168861620ENST00000392736016969_99101052.0Zinc fingerC2H2-type 10
TgeneMECOMchr3:167742314chr3:168861620ENST00000433243117209_23601053.0Zinc fingerC2H2-type 1
TgeneMECOMchr3:167742314chr3:168861620ENST00000433243117263_28501053.0Zinc fingerC2H2-type 2
TgeneMECOMchr3:167742314chr3:168861620ENST00000433243117291_31301053.0Zinc fingerC2H2-type 3
TgeneMECOMchr3:167742314chr3:168861620ENST00000433243117319_34201053.0Zinc fingerC2H2-type 4
TgeneMECOMchr3:167742314chr3:168861620ENST00000433243117348_37001053.0Zinc fingerC2H2-type 5
TgeneMECOMchr3:167742314chr3:168861620ENST00000433243117376_39801053.0Zinc fingerC2H2-type 6
TgeneMECOMchr3:167742314chr3:168861620ENST00000433243117405_42701053.0Zinc fingerC2H2-type 7%3B atypical
TgeneMECOMchr3:167742314chr3:168861620ENST00000433243117912_93401053.0Zinc fingerC2H2-type 8
TgeneMECOMchr3:167742314chr3:168861620ENST00000433243117940_96301053.0Zinc fingerC2H2-type 9
TgeneMECOMchr3:167742314chr3:168861620ENST00000433243117969_99101053.0Zinc fingerC2H2-type 10
TgeneMECOMchr3:167742314chr3:168861620ENST00000464456015209_23601043.0Zinc fingerC2H2-type 1
TgeneMECOMchr3:167742314chr3:168861620ENST00000464456015263_28501043.0Zinc fingerC2H2-type 2
TgeneMECOMchr3:167742314chr3:168861620ENST00000464456015291_31301043.0Zinc fingerC2H2-type 3
TgeneMECOMchr3:167742314chr3:168861620ENST00000464456015319_34201043.0Zinc fingerC2H2-type 4
TgeneMECOMchr3:167742314chr3:168861620ENST00000464456015348_37001043.0Zinc fingerC2H2-type 5
TgeneMECOMchr3:167742314chr3:168861620ENST00000464456015376_39801043.0Zinc fingerC2H2-type 6
TgeneMECOMchr3:167742314chr3:168861620ENST00000464456015405_42701043.0Zinc fingerC2H2-type 7%3B atypical
TgeneMECOMchr3:167742314chr3:168861620ENST00000464456015912_93401043.0Zinc fingerC2H2-type 8
TgeneMECOMchr3:167742314chr3:168861620ENST00000464456015940_96301043.0Zinc fingerC2H2-type 9
TgeneMECOMchr3:167742314chr3:168861620ENST00000464456015969_99101043.0Zinc fingerC2H2-type 10
TgeneMECOMchr3:167742314chr3:168861620ENST00000468789016209_23601052.0Zinc fingerC2H2-type 1
TgeneMECOMchr3:167742314chr3:168861620ENST00000468789016263_28501052.0Zinc fingerC2H2-type 2
TgeneMECOMchr3:167742314chr3:168861620ENST00000468789016291_31301052.0Zinc fingerC2H2-type 3
TgeneMECOMchr3:167742314chr3:168861620ENST00000468789016319_34201052.0Zinc fingerC2H2-type 4
TgeneMECOMchr3:167742314chr3:168861620ENST00000468789016348_37001052.0Zinc fingerC2H2-type 5
TgeneMECOMchr3:167742314chr3:168861620ENST00000468789016376_39801052.0Zinc fingerC2H2-type 6
TgeneMECOMchr3:167742314chr3:168861620ENST00000468789016405_42701052.0Zinc fingerC2H2-type 7%3B atypical
TgeneMECOMchr3:167742314chr3:168861620ENST00000468789016912_93401052.0Zinc fingerC2H2-type 8
TgeneMECOMchr3:167742314chr3:168861620ENST00000468789016940_96301052.0Zinc fingerC2H2-type 9
TgeneMECOMchr3:167742314chr3:168861620ENST00000468789016969_99101052.0Zinc fingerC2H2-type 10
TgeneMECOMchr3:167742314chr3:168861620ENST00000472280016209_23601053.0Zinc fingerC2H2-type 1
TgeneMECOMchr3:167742314chr3:168861620ENST00000472280016263_28501053.0Zinc fingerC2H2-type 2
TgeneMECOMchr3:167742314chr3:168861620ENST00000472280016291_31301053.0Zinc fingerC2H2-type 3
TgeneMECOMchr3:167742314chr3:168861620ENST00000472280016319_34201053.0Zinc fingerC2H2-type 4
TgeneMECOMchr3:167742314chr3:168861620ENST00000472280016348_37001053.0Zinc fingerC2H2-type 5
TgeneMECOMchr3:167742314chr3:168861620ENST00000472280016376_39801053.0Zinc fingerC2H2-type 6
TgeneMECOMchr3:167742314chr3:168861620ENST00000472280016405_42701053.0Zinc fingerC2H2-type 7%3B atypical
TgeneMECOMchr3:167742314chr3:168861620ENST00000472280016912_93401053.0Zinc fingerC2H2-type 8
TgeneMECOMchr3:167742314chr3:168861620ENST00000472280016940_96301053.0Zinc fingerC2H2-type 9
TgeneMECOMchr3:167742314chr3:168861620ENST00000472280016969_99101053.0Zinc fingerC2H2-type 10

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGOLIM4chr3:167742314chr3:168861620ENST00000470487-1416311_681620697.0Compositional biasNote=Glu-rich
HgeneGOLIM4chr3:167742314chr3:168861620ENST00000470487-141634_696620697.0Topological domainLumenal


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Fusion Gene Sequence for GOLIM4-MECOM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>33948_33948_1_GOLIM4-MECOM_GOLIM4_chr3_167742314_ENST00000309027_MECOM_chr3_168861620_ENST00000264674_length(transcript)=6593nt_BP=1835nt
GCTCGGACCAAGGGGAGGAGACGGCGGGGGCGGCCGCGGCTTTGGGTCCAGGCGGGACTATGGGAAACGGGATGTGCTCCCGAAAGCAGA
AGCGGATTTTCCAGACGCTGCTGCTGCTGACCGTCGTGTTCGGCTTTCTCTACGGCGCGATGCTCTACTACGAGCTGCAGACGCAGCTGC
GGAAAGCCGAGGCGGTGGCGCTCAAGTACCAGCAGCACCAGGAGTCCCTCTCCGCCCAGTTACAAGTTGTATATGAACACAGATCAAGAT
TAGAGAAATCCTTGCAAAAAGAAAGACTTGAACATAAAAAAGCAAAGGAAGATTTTCTTGTTTATAAGTTAGAAGCACAAGAAACATTAA
ATAAAGGAAGGCAAGATTCCAATAGCAGATACAGTGCACTGAATGTCCAACATCAGATGTTGAAAAGCCAACACGAGGAGCTAAAGAAAC
AGCACAGTGACTTGGAAGAGGAACATCGCAAACAAGGGGAAGACTTCAGTAGAACATTTAATGACCATAAGCAAAAATACTTGCAGCTCC
AGCAAGAAAAAGAACAAGAACTTTCTAAGCTAAAAGAGACTGTATACAATTTGAGAGAAGAGAATAGACAACTAAGGAAAGCACACCAAG
ACATACATACACAGCTTCAAGATGTCAAGACTCAAGTTGCAGAATATAAACAACTGAAAGATACTCTGAATAGGATTCCAAGCCTTCGAA
AACCTGATCCAGCAGAACAGCAAAATGTGACCCAGGTGGCACATTCTCCACAAGGTTACAACACAGCAAGGGAGAAGCCAACCCGAGAGG
TGCAGGAGGTGTCTCGAAATAATGATGTGTGGCAGAACCATGAAGCAGTTCCTGGAAGAGCAGAAGACACAAAACTCTATGCTCCCACCC
ATAAGGAGGCAGAATTTCAGGCTCCCCCAGAGCCAATCCAACAAGAAGTGGAACGCAGAGAACCTGAGGAGCATCAGGTGGAAGAGGAGC
ACAGAAAGGCCCTGGAGGAGGAAGAAATGGAGCAGGTCGGGCAAGCAGAACATCTTGAGGAGGAACACGATCCATCACCAGAGGAGCAGG
ATCGGGAGTGGAAAGAGCAGCATGAGCAACGAGAAGCAGCCAACCTCCTGGAAGGGCACGCGCGTGCTGAGGTGTACCCTTCAGCCAAGC
CAATGATCAAATTCCAATCACCCTATGAGGAACAGTTGGAACAGCAGAGACTGGCAGTGCAGCAGGTGGAGGAGGCCCAGCAGCTGCGGG
AACACCAGGAAGCTTTGCACCAGCAGAGGCTGCAGGGGCACTTACTACGGCAGCAGGAACAGCAGCAGCAGCAGGTGGCAAGAGAGATGG
CCCTGCAGAGGCAGGCTGAGCTTGAGGAGGGCCGGCCGCAGCACCAGGAGCAGCTCCGGCAGCAAGCTCATTATGATGCTATGGATAATG
ATATCGTTCAGGGAGCAGAGGACCAGGGAATCCAAGGAGAGGAAGGAGCCTATGAAAGAGACAACCAGCACCAAGATGAAGCAGAAGGAG
ATCCAGGTAATAGACATGAGCCTCGTGAACAAGGACCCCGAGAAGCCGACCCAGAATCTGAGGCAGATAGGGCAGCTGTAGAAGATATAA
ACCCAGCAGATGACCCTAATAATCAAGGTGAGGATGAATTTGAAGAAGCCGAGCAAGTGAGAGAAGAAAATTTGCCAGATGAAAATGAAG
AGCAAAAACAAAGTAATCAAAAGCAAGAGAATACAGAAGTGGAGGAACATTTGGTGATGGCAGGAAATCCAGACCAGCAGGAGGACAATG
TTGATGAACAGTACCAGGAAGAGGCAGAAGAGGAGATCTTAGACGAATTTTACAATGTGAAGTTCTGCATAGATGCCAGTCAACCAGATG
TTGGAAGCTGGCTCAAGTACATTAGATTCGCTGGCTGTTATGATCAGCACAACCTTGTTGCATGCCAGATAAATGATCAGATATTCTATA
GAGTAGTTGCAGACATTGCGCCGGGAGAGGAGCTTCTGCTGTTCATGAAGAGCGAAGACTATCCCCATGAAACTATGGCGCCGGATATCC
ACGAAGAACGGCAATATCGCTGCGAAGACTGTGACCAGCTCTTTGAATCTAAGGCTGAACTAGCAGATCACCAAAAGTTTCCATGCAGTA
CTCCTCACTCAGCATTTTCAATGGTTGAAGAGGACTTTCAGCAAAAACTCGAAAGCGAGAATGATCTCCAAGAGATACACACGATCCAGG
AGTGTAAGGAATGTGACCAAGTTTTTCCTGATTTGCAAAGCCTGGAGAAACACATGCTGTCACATACTGAAGAGAGGGAATACAAGTGTG
ATCAGTGTCCCAAGGCATTTAACTGGAAGTCCAATTTAATTCGCCACCAGATGTCACATGACAGTGGAAAGCACTATGAATGTGAAAACT
GTGCCAAGCAGGTTTTCACGGACCCTAGCAACCTTCAGCGGCACATTCGCTCTCAGCATGTCGGTGCCCGGGCCCATGCATGCCCGGAGT
GTGGCAAAACGTTTGCCACTTCGTCGGGCCTCAAACAACACAAGCACATCCACAGCAGTGTGAAGCCCTTTATCTGTGAGGTCTGCCATA
AATCCTATACTCAGTTTTCAAACCTTTGCCGTCATAAGCGCATGCATGCTGATTGCAGAACCCAAATCAAGTGCAAAGACTGTGGACAAA
TGTTCAGCACTACGTCTTCCTTAAATAAACACAGGAGGTTTTGTGAGGGCAAGAACCATTTTGCGGCAGGTGGATTTTTTGGCCAAGGCA
TTTCACTTCCTGGAACCCCAGCTATGGATAAAACGTCCATGGTTAATATGAGTCATGCCAACCCGGGCCTTGCTGACTATTTTGGCGCCA
ATAGGCATCCTGCTGGTCTTACCTTTCCAACAGCTCCTGGATTTTCTTTTAGCTTCCCTGGTCTGTTTCCTTCCGGCTTGTACCACAGGC
CTCCTTTGATACCTGCTAGTTCTCCTGTTAAAGGACTATCAAGTACTGAACAGACAAACAAAAGTCAAAGTCCCCTCATGACACATCCTC
AGATACTGCCAGCTACACAGGATATTTTGAAGGCACTATCTAAACACCCATCTGTAGGGGACAATAAGCCAGTGGAGCTCCAGCCCGAGA
GGTCCTCTGAAGAGAGGCCCTTTGAGAAAATCAGTGACCAGTCAGAGAGTAGTGACCTTGATGATGTCAGTACACCAAGTGGCAGTGACC
TGGAAACAACCTCGGGCTCTGATCTGGAAAGTGACATTGAAAGTGATAAAGAGAAATTTAAAGAAAATGGTAAAATGTTCAAAGACAAAG
TAAGCCCTCTTCAGAATCTGGCTTCAATAAATAATAAGAAAGAATACAGCAATCATTCCATTTTCTCACCATCTTTAGAGGAGCAGACTG
CGGTGTCAGGAGCTGTGAATGATTCTATAAAGGCTATTGCTTCTATTGCTGAAAAATACTTTGGTTCAACAGGACTGGTGGGGCTGCAAG
ACAAAAAAGTTGGAGCTTTACCTTACCCTTCCATGTTTCCCCTCCCATTTTTTCCAGCATTCTCTCAATCAATGTACCCATTTCCTGATA
GAGACTTGAGATCGTTACCTTTGAAAATGGAACCCCAATCACCAGGTGAAGTAAAGAAACTGCAGAAGGGCAGCTCTGAGTCCCCCTTTG
ATCTCACCACTAAGCGAAAGGATGAGAAGCCCTTGACTCCAGTCCCCTCCAAGCCTCCAGTGACACCTGCCACAAGCCAAGACCAGCCCC
TGGATCTAAGTATGGGCAGTAGGAGTAGAGCCAGTGGGACAAAGCTGACTGAGCCTCGAAAAAACCACGTGTTTGGGGGAAAAAAAGGAA
GCAACGTCGAATCAAGACCTGCTTCAGATGGTTCCTTGCAGCATGCAAGACCCACTCCTTTCTTTATGGACCCTATTTACAGAGTAGAGA
AAAGAAAACTAACTGACCCACTTGAAGCTTTAAAAGAGAAATACTTGAGGCCTTCTCCAGGATTCTTGTTTCACCCACAATTCCAACTGC
CTGATCAGAGAACTTGGATGTCAGCTATTGAAAACATGGCAGAAAAGCTAGAGAGCTTCAGTGCCCTGAAACCTGAGGCCAGTGAGCTCT
TACAGTCAGTGCCCTCTATGTTCAACTTCAGGGCGCCTCCCAATGCCCTGCCAGAGAACCTTCTGCGGAAGGGAAAGGAGCGCTATACCT
GCAGATACTGTGGCAAGATTTTTCCAAGGTCTGCAAACCTAACACGGCACTTGAGAACCCACACAGGAGAGCAGCCTTACAGATGCAAAT
ACTGTGACAGATCATTTAGCATATCTTCTAACTTGCAAAGGCATGTTCGCAACATCCACAATAAAGAGAAGCCATTTAAGTGTCACTTAT
GTGATAGGTGTTTTGGTCAACAAACCAATTTAGACAGACACCTAAAGAAACATGAGAATGGGAACATGTCCGGTACAGCAACATCGTCGC
CTCATTCTGAACTGGAAAGTACAGGTGCGATTCTGGATGACAAAGAAGATGCTTACTTCACAGAAATTCGAAATTTCATTGGGAACAGCA
ACCATGGCAGCCAATCTCCCAGGAATGTGGAGGAGAGAATGAATGGCAGTCATTTTAAAGATGAAAAGGCTTTGGTGACCAGTCAAAATT
CAGACTTGCTGGATGATGAAGAAGTTGAAGATGAGGTGTTGTTAGATGAGGAGGATGAAGACAATGATATTACTGGAAAAACAGGAAAGG
AACCAGTGACAAGTAATTTACATGAAGGAAACCCTGAGGATGACTATGAAGAAACCAGTGCCCTGGAGATGAGTTGCAAGACATCCCCAG
TGAGGTATAAAGAGGAAGAATATAAAAGTGGACTTTCTGCTCTAGATCATATAAGGCACTTCACAGATAGCCTCAAAATGAGGAAAATGG
AAGATAATCAATATTCTGAAGCTGAGCTGTCTTCTTTTAGTACTTCCCATGTGCCAGAGGAACTTAAGCAGCCGTTACACAGAAAGTCCA
AATCGCAGGCATATGCTATGATGCTGTCACTGTCTGACAAGGAGTCCCTCCATTCTACATCCCACAGTTCTTCCAACGTGTGGCACAGTA
TGGCCAGGGCTGCGGCGGAATCCAGTGCTATCCAGTCCATAAGCCACGTATGACGTTATCAAGGTTGACCAGAGTGGGACCAAGTCCAAC
AGTAGCATGGCTCTTTCATATAGGACTATTTACAAGACTGCTGAGCAGAATGCCTTATAAACCTGCAGGGTCACTCATCTAAAGTCTAGT
GACCTTAAACTGAATGATTTAAAAAAGAAAAGAAAGAAAAAAGAAACTATTTATTCTCGATATTTTGTTTTGCACAGCAAAGGCAGCTGC
TGACTTCTGGAAGATCAATCAATGCGACTTAAAGTGATTCAGTGAAAACAAAAAACTTGGTGGGCTGAAGGCATCTTCCAGTTTACCCCA
CCTTAGGGTATGGGTGGGTGAGAAGGGCAGTTGAGATGGCAGCATTGATATGAATGAACACTCCATAGAAACTGAATTCTCTTTTGTACA
AGATCACCTGACATGATTGGGAACAGTTGCTTTTAATTACAGATTTAATTTTTTTCTTCGTTAAAGTTTTATGTAATTTAACCCTTTGAA
GACAGAAGTAGTTGGATGAAATGCACAGTCAATTATTATAGAAACTGATAACAGGGAGTACTTGTTCCCCCTTTTGCCTTCTTAAGTACA
TTGTTTAAAACTAGGGAAAAAGGGTATGTGTATATTGTAAACTATGGATGTTAACACTCAAAGAGGTTAAGTCAGTGAAGTAACCTATTC
ATCACCAGTACCGCTGTACCACTAATAAATTGTTTGCCAAATCCTTGTAATAACATCTTAATTTTAGACAATCATGTCACTGTTTTTAAT
GTTTATTTTTTTGTGTGTGTTGCGTGTATCATGTATTTATTTGTTGGCAAACTATTGTTTGTTGATTAAAATAGCACTGTTCCAGTCAGC
CACTACTTTATGACGTCTGAGGCACACCCCTTTCCGAATTTCAAGGACCAAGGTGACCCGACCTGTGTATGAGAGTGCCAAATGGTGTTT
GGCTTTTCTTAACATTCCTTTTTGTTTGTTTGTTTTGTTTTCCTTCTTAATGAACTAAATACGAATAGATGCAACTTAGTTTTTGTAATA
CTGAAATCGATTCAATTGTATAAACGATTATAATTTCTTTCATGGAAGCATGATTCTTCTGATTAAAAACTGTACTCCATATTTTATGCT
GGTTGTCTGCAAGCTTGTGCGATGTTATGTTCATGTTAATCCTATTTGTAAAATGAAGTGTTCCCAACCTTATGTTAAAAGAGAGAAGTA
AATAACAGACTGTATTCAGTTATTTTGCCCTTTATTGAGGAACCAGATTTGTTTTCTTTTTGTTTGTAATCTCATTTTGAAATAATCAGC
AAGTTGAGGTACTTTCTTCAAATGCTTTGTACAATATAAACTGTTATGCCTTTCAGTGCATTACTATGGGAGGAGCAACTAAAAAATAAA

>33948_33948_1_GOLIM4-MECOM_GOLIM4_chr3_167742314_ENST00000309027_MECOM_chr3_168861620_ENST00000264674_length(amino acids)=1713AA_BP=598
MGPGGTMGNGMCSRKQKRIFQTLLLLTVVFGFLYGAMLYYELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKK
AKEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYLQLQQEKEQELSKLKET
VYNLREENRQLRKAHQDIHTQLQDVKTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNH
EAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAA
NLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQ
HQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVEDINPADDPNNQGEDEF
EEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEILDEFYNVKFCIDASQPDVGSWLKYIRFAGCY
DQHNLVACQINDQIFYRVVADIAPGEELLLFMKSEDYPHETMAPDIHEERQYRCEDCDQLFESKAELADHQKFPCSTPHSAFSMVEEDFQ
QKLESENDLQEIHTIQECKECDQVFPDLQSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKHYECENCAKQVFTDPSNLQR
HIRSQHVGARAHACPECGKTFATSSGLKQHKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRF
CEGKNHFAAGGFFGQGISLPGTPAMDKTSMVNMSHANPGLADYFGANRHPAGLTFPTAPGFSFSFPGLFPSGLYHRPPLIPASSPVKGLS
STEQTNKSQSPLMTHPQILPATQDILKALSKHPSVGDNKPVELQPERSSEERPFEKISDQSESSDLDDVSTPSGSDLETTSGSDLESDIE
SDKEKFKENGKMFKDKVSPLQNLASINNKKEYSNHSIFSPSLEEQTAVSGAVNDSIKAIASIAEKYFGSTGLVGLQDKKVGALPYPSMFP
LPFFPAFSQSMYPFPDRDLRSLPLKMEPQSPGEVKKLQKGSSESPFDLTTKRKDEKPLTPVPSKPPVTPATSQDQPLDLSMGSRSRASGT
KLTEPRKNHVFGGKKGSNVESRPASDGSLQHARPTPFFMDPIYRVEKRKLTDPLEALKEKYLRPSPGFLFHPQFQLPDQRTWMSAIENMA
EKLESFSALKPEASELLQSVPSMFNFRAPPNALPENLLRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQR
HVRNIHNKEKPFKCHLCDRCFGQQTNLDRHLKKHENGNMSGTATSSPHSELESTGAILDDKEDAYFTEIRNFIGNSNHGSQSPRNVEERM
NGSHFKDEKALVTSQNSDLLDDEEVEDEVLLDEEDEDNDITGKTGKEPVTSNLHEGNPEDDYEETSALEMSCKTSPVRYKEEEYKSGLSA
LDHIRHFTDSLKMRKMEDNQYSEAELSSFSTSHVPEELKQPLHRKSKSQAYAMMLSLSDKESLHSTSHSSSNVWHSMARAAAESSAIQSI

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>33948_33948_2_GOLIM4-MECOM_GOLIM4_chr3_167742314_ENST00000470487_MECOM_chr3_168861620_ENST00000264674_length(transcript)=7308nt_BP=2550nt
AATGAGCAAGGAGGCCGAGTGGGACTTCCTCCCGGAATCCCGTTGGCCAGAATAGCCGGGCCGTGGGTGACACGTAAGTTGGGCAGGAGG
TGGCGGGGCGGCAGAGGCACCAGCCGACCCGTCAGTGACACCGCTGTGCCGTCCCCAAAACCAGCCGAGACAGCTGGCCCCCACCCTTCC
ACCCATTGGGCAGGCCGCACGGGGGCGCGGCCCGGAGTCCTGGTCCCTTTGTTGGGCGCGCACCCCCTCCCTTAGGTGGCAACAAAGTCG
TGCAGTGGGAGCCGCCGCGATAGGGCGGGGAGTGGCCAGGGCGGGACTCCAAGAACTGCCCGGGGGCAGCGGGGCCAAAAAGTGGGAAGA
AGGAAAAAAGGCAGGAGGCATCTGGGGACAGGCGCGAGGGCAGCCGGCTCTGAAGTATGCGGAGGGCCTCCTCCCGGCCCCGGGCATTCG
CGGAGAACGAGCCTCGCAGAAGTTTGGCTGCAGCTGCCCGGGCGGCGTCGATGGCTGCGCGCCCCGCGCCGCGCGGGGGCTGAGCGGGCG
CCACTTCCCCTCCGGGCCGGCTTTTGTGTCTGGCATCTCCTCCTCATGCTGCGTCTGGCCACCTACTGCGGCGGCCGCTGCTGAGACGCT
CGCTCGGACCAAGGGGAGGAGACGGCGGGGGCGGCCGCGGCTTTGGGTCCAGGCGGGACTATGGGAAACGGGATGTGCTCCCGAAAGCAG
AAGCGGATTTTCCAGACGCTGCTGCTGCTGACCGTCGTGTTCGGCTTTCTCTACGGCGCGATGCTCTACTACGAGCTGCAGACGCAGCTG
CGGAAAGCCGAGGCGGTGGCGCTCAAGTACCAGCAGCACCAGGAGTCCCTCTCCGCCCAGTTACAAGTTGTATATGAACACAGATCAAGA
TTAGAGAAATCCTTGCAAAAAGAAAGACTTGAACATAAAAAAGCAAAGGAAGATTTTCTTGTTTATAAGTTAGAAGCACAAGAAACATTA
AATAAAGGAAGGCAAGATTCCAATAGCAGATACAGTGCACTGAATGTCCAACATCAGATGTTGAAAAGCCAACACGAGGAGCTAAAGAAA
CAGCACAGTGACTTGGAAGAGGAACATCGCAAACAAGGGGAAGACTTCAGTAGAACATTTAATGACCATAAGCAAAAATACTTGCAGCTC
CAGCAAGAAAAAGAACAAGAACTTTCTAAGCTAAAAGAGACTGTATACAATTTGAGAGAAGAGAATAGACAACTAAGGAAAGCACACCAA
GACATACATACACAGCTTCAAGATGTCAAGCAACAGCATAAGAATTTACTCTCCGAGCATGAACAACTTGTAGTGACTTTGGAAGACCAC
AAGAGTGCACTAGCTGCTGCACAGACTCAAGTTGCAGAATATAAACAACTGAAAGATACTCTGAATAGGATTCCAAGCCTTCGAAAACCT
GATCCAGCAGAACAGCAAAATGTGACCCAGGTGGCACATTCTCCACAAGGTTACAACACAGCAAGGGAGAAGCCAACCCGAGAGGTGCAG
GAGGTGTCTCGAAATAATGATGTGTGGCAGAACCATGAAGCAGTTCCTGGAAGAGCAGAAGACACAAAACTCTATGCTCCCACCCATAAG
GAGGCAGAATTTCAGGCTCCCCCAGAGCCAATCCAACAAGAAGTGGAACGCAGAGAACCTGAGGAGCATCAGGTGGAAGAGGAGCACAGA
AAGGCCCTGGAGGAGGAAGAAATGGAGCAGGTCGGGCAAGCAGAACATCTTGAGGAGGAACACGATCCATCACCAGAGGAGCAGGATCGG
GAGTGGAAAGAGCAGCATGAGCAACGAGAAGCAGCCAACCTCCTGGAAGGGCACGCGCGTGCTGAGGTGTACCCTTCAGCCAAGCCAATG
ATCAAATTCCAATCACCCTATGAGGAACAGTTGGAACAGCAGAGACTGGCAGTGCAGCAGGTGGAGGAGGCCCAGCAGCTGCGGGAACAC
CAGGAAGCTTTGCACCAGCAGAGGCTGCAGGGGCACTTACTACGGCAGCAGGAACAGCAGCAGCAGCAGGTGGCAAGAGAGATGGCCCTG
CAGAGGCAGGCTGAGCTTGAGGAGGGCCGGCCGCAGCACCAGGAGCAGCTCCGGCAGCAAGCTCATTATGATGCTATGGATAATGATATC
GTTCAGGGAGCAGAGGACCAGGGAATCCAAGGAGAGGAAGGAGCCTATGAAAGAGACAACCAGCACCAAGATGAAGCAGAAGGAGATCCA
GGTAATAGACATGAGCCTCGTGAACAAGGACCCCGAGAAGCCGACCCAGAATCTGAGGCAGATAGGGCAGCTGTAGAAGATATAAACCCA
GCAGATGACCCTAATAATCAAGGTGAGGATGAATTTGAAGAAGCCGAGCAAGTGAGAGAAGAAAATTTGCCAGATGAAAATGAAGAGCAA
AAACAAAGTAATCAAAAGCAAGAGAATACAGAAGTGGAGGAACATTTGGTGATGGCAGGAAATCCAGACCAGCAGGAGGACAATGTTGAT
GAACAGTACCAGGAAGAGGCAGAAGAGGAGATCTTAGACGAATTTTACAATGTGAAGTTCTGCATAGATGCCAGTCAACCAGATGTTGGA
AGCTGGCTCAAGTACATTAGATTCGCTGGCTGTTATGATCAGCACAACCTTGTTGCATGCCAGATAAATGATCAGATATTCTATAGAGTA
GTTGCAGACATTGCGCCGGGAGAGGAGCTTCTGCTGTTCATGAAGAGCGAAGACTATCCCCATGAAACTATGGCGCCGGATATCCACGAA
GAACGGCAATATCGCTGCGAAGACTGTGACCAGCTCTTTGAATCTAAGGCTGAACTAGCAGATCACCAAAAGTTTCCATGCAGTACTCCT
CACTCAGCATTTTCAATGGTTGAAGAGGACTTTCAGCAAAAACTCGAAAGCGAGAATGATCTCCAAGAGATACACACGATCCAGGAGTGT
AAGGAATGTGACCAAGTTTTTCCTGATTTGCAAAGCCTGGAGAAACACATGCTGTCACATACTGAAGAGAGGGAATACAAGTGTGATCAG
TGTCCCAAGGCATTTAACTGGAAGTCCAATTTAATTCGCCACCAGATGTCACATGACAGTGGAAAGCACTATGAATGTGAAAACTGTGCC
AAGCAGGTTTTCACGGACCCTAGCAACCTTCAGCGGCACATTCGCTCTCAGCATGTCGGTGCCCGGGCCCATGCATGCCCGGAGTGTGGC
AAAACGTTTGCCACTTCGTCGGGCCTCAAACAACACAAGCACATCCACAGCAGTGTGAAGCCCTTTATCTGTGAGGTCTGCCATAAATCC
TATACTCAGTTTTCAAACCTTTGCCGTCATAAGCGCATGCATGCTGATTGCAGAACCCAAATCAAGTGCAAAGACTGTGGACAAATGTTC
AGCACTACGTCTTCCTTAAATAAACACAGGAGGTTTTGTGAGGGCAAGAACCATTTTGCGGCAGGTGGATTTTTTGGCCAAGGCATTTCA
CTTCCTGGAACCCCAGCTATGGATAAAACGTCCATGGTTAATATGAGTCATGCCAACCCGGGCCTTGCTGACTATTTTGGCGCCAATAGG
CATCCTGCTGGTCTTACCTTTCCAACAGCTCCTGGATTTTCTTTTAGCTTCCCTGGTCTGTTTCCTTCCGGCTTGTACCACAGGCCTCCT
TTGATACCTGCTAGTTCTCCTGTTAAAGGACTATCAAGTACTGAACAGACAAACAAAAGTCAAAGTCCCCTCATGACACATCCTCAGATA
CTGCCAGCTACACAGGATATTTTGAAGGCACTATCTAAACACCCATCTGTAGGGGACAATAAGCCAGTGGAGCTCCAGCCCGAGAGGTCC
TCTGAAGAGAGGCCCTTTGAGAAAATCAGTGACCAGTCAGAGAGTAGTGACCTTGATGATGTCAGTACACCAAGTGGCAGTGACCTGGAA
ACAACCTCGGGCTCTGATCTGGAAAGTGACATTGAAAGTGATAAAGAGAAATTTAAAGAAAATGGTAAAATGTTCAAAGACAAAGTAAGC
CCTCTTCAGAATCTGGCTTCAATAAATAATAAGAAAGAATACAGCAATCATTCCATTTTCTCACCATCTTTAGAGGAGCAGACTGCGGTG
TCAGGAGCTGTGAATGATTCTATAAAGGCTATTGCTTCTATTGCTGAAAAATACTTTGGTTCAACAGGACTGGTGGGGCTGCAAGACAAA
AAAGTTGGAGCTTTACCTTACCCTTCCATGTTTCCCCTCCCATTTTTTCCAGCATTCTCTCAATCAATGTACCCATTTCCTGATAGAGAC
TTGAGATCGTTACCTTTGAAAATGGAACCCCAATCACCAGGTGAAGTAAAGAAACTGCAGAAGGGCAGCTCTGAGTCCCCCTTTGATCTC
ACCACTAAGCGAAAGGATGAGAAGCCCTTGACTCCAGTCCCCTCCAAGCCTCCAGTGACACCTGCCACAAGCCAAGACCAGCCCCTGGAT
CTAAGTATGGGCAGTAGGAGTAGAGCCAGTGGGACAAAGCTGACTGAGCCTCGAAAAAACCACGTGTTTGGGGGAAAAAAAGGAAGCAAC
GTCGAATCAAGACCTGCTTCAGATGGTTCCTTGCAGCATGCAAGACCCACTCCTTTCTTTATGGACCCTATTTACAGAGTAGAGAAAAGA
AAACTAACTGACCCACTTGAAGCTTTAAAAGAGAAATACTTGAGGCCTTCTCCAGGATTCTTGTTTCACCCACAATTCCAACTGCCTGAT
CAGAGAACTTGGATGTCAGCTATTGAAAACATGGCAGAAAAGCTAGAGAGCTTCAGTGCCCTGAAACCTGAGGCCAGTGAGCTCTTACAG
TCAGTGCCCTCTATGTTCAACTTCAGGGCGCCTCCCAATGCCCTGCCAGAGAACCTTCTGCGGAAGGGAAAGGAGCGCTATACCTGCAGA
TACTGTGGCAAGATTTTTCCAAGGTCTGCAAACCTAACACGGCACTTGAGAACCCACACAGGAGAGCAGCCTTACAGATGCAAATACTGT
GACAGATCATTTAGCATATCTTCTAACTTGCAAAGGCATGTTCGCAACATCCACAATAAAGAGAAGCCATTTAAGTGTCACTTATGTGAT
AGGTGTTTTGGTCAACAAACCAATTTAGACAGACACCTAAAGAAACATGAGAATGGGAACATGTCCGGTACAGCAACATCGTCGCCTCAT
TCTGAACTGGAAAGTACAGGTGCGATTCTGGATGACAAAGAAGATGCTTACTTCACAGAAATTCGAAATTTCATTGGGAACAGCAACCAT
GGCAGCCAATCTCCCAGGAATGTGGAGGAGAGAATGAATGGCAGTCATTTTAAAGATGAAAAGGCTTTGGTGACCAGTCAAAATTCAGAC
TTGCTGGATGATGAAGAAGTTGAAGATGAGGTGTTGTTAGATGAGGAGGATGAAGACAATGATATTACTGGAAAAACAGGAAAGGAACCA
GTGACAAGTAATTTACATGAAGGAAACCCTGAGGATGACTATGAAGAAACCAGTGCCCTGGAGATGAGTTGCAAGACATCCCCAGTGAGG
TATAAAGAGGAAGAATATAAAAGTGGACTTTCTGCTCTAGATCATATAAGGCACTTCACAGATAGCCTCAAAATGAGGAAAATGGAAGAT
AATCAATATTCTGAAGCTGAGCTGTCTTCTTTTAGTACTTCCCATGTGCCAGAGGAACTTAAGCAGCCGTTACACAGAAAGTCCAAATCG
CAGGCATATGCTATGATGCTGTCACTGTCTGACAAGGAGTCCCTCCATTCTACATCCCACAGTTCTTCCAACGTGTGGCACAGTATGGCC
AGGGCTGCGGCGGAATCCAGTGCTATCCAGTCCATAAGCCACGTATGACGTTATCAAGGTTGACCAGAGTGGGACCAAGTCCAACAGTAG
CATGGCTCTTTCATATAGGACTATTTACAAGACTGCTGAGCAGAATGCCTTATAAACCTGCAGGGTCACTCATCTAAAGTCTAGTGACCT
TAAACTGAATGATTTAAAAAAGAAAAGAAAGAAAAAAGAAACTATTTATTCTCGATATTTTGTTTTGCACAGCAAAGGCAGCTGCTGACT
TCTGGAAGATCAATCAATGCGACTTAAAGTGATTCAGTGAAAACAAAAAACTTGGTGGGCTGAAGGCATCTTCCAGTTTACCCCACCTTA
GGGTATGGGTGGGTGAGAAGGGCAGTTGAGATGGCAGCATTGATATGAATGAACACTCCATAGAAACTGAATTCTCTTTTGTACAAGATC
ACCTGACATGATTGGGAACAGTTGCTTTTAATTACAGATTTAATTTTTTTCTTCGTTAAAGTTTTATGTAATTTAACCCTTTGAAGACAG
AAGTAGTTGGATGAAATGCACAGTCAATTATTATAGAAACTGATAACAGGGAGTACTTGTTCCCCCTTTTGCCTTCTTAAGTACATTGTT
TAAAACTAGGGAAAAAGGGTATGTGTATATTGTAAACTATGGATGTTAACACTCAAAGAGGTTAAGTCAGTGAAGTAACCTATTCATCAC
CAGTACCGCTGTACCACTAATAAATTGTTTGCCAAATCCTTGTAATAACATCTTAATTTTAGACAATCATGTCACTGTTTTTAATGTTTA
TTTTTTTGTGTGTGTTGCGTGTATCATGTATTTATTTGTTGGCAAACTATTGTTTGTTGATTAAAATAGCACTGTTCCAGTCAGCCACTA
CTTTATGACGTCTGAGGCACACCCCTTTCCGAATTTCAAGGACCAAGGTGACCCGACCTGTGTATGAGAGTGCCAAATGGTGTTTGGCTT
TTCTTAACATTCCTTTTTGTTTGTTTGTTTTGTTTTCCTTCTTAATGAACTAAATACGAATAGATGCAACTTAGTTTTTGTAATACTGAA
ATCGATTCAATTGTATAAACGATTATAATTTCTTTCATGGAAGCATGATTCTTCTGATTAAAAACTGTACTCCATATTTTATGCTGGTTG
TCTGCAAGCTTGTGCGATGTTATGTTCATGTTAATCCTATTTGTAAAATGAAGTGTTCCCAACCTTATGTTAAAAGAGAGAAGTAAATAA
CAGACTGTATTCAGTTATTTTGCCCTTTATTGAGGAACCAGATTTGTTTTCTTTTTGTTTGTAATCTCATTTTGAAATAATCAGCAAGTT
GAGGTACTTTCTTCAAATGCTTTGTACAATATAAACTGTTATGCCTTTCAGTGCATTACTATGGGAGGAGCAACTAAAAAATAAAGACTT

>33948_33948_2_GOLIM4-MECOM_GOLIM4_chr3_167742314_ENST00000470487_MECOM_chr3_168861620_ENST00000264674_length(amino acids)=1741AA_BP=626
MGPGGTMGNGMCSRKQKRIFQTLLLLTVVFGFLYGAMLYYELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKK
AKEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYLQLQQEKEQELSKLKET
VYNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHS
PQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQA
EHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLL
RQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREA
DPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEILDE
FYNVKFCIDASQPDVGSWLKYIRFAGCYDQHNLVACQINDQIFYRVVADIAPGEELLLFMKSEDYPHETMAPDIHEERQYRCEDCDQLFE
SKAELADHQKFPCSTPHSAFSMVEEDFQQKLESENDLQEIHTIQECKECDQVFPDLQSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIRH
QMSHDSGKHYECENCAKQVFTDPSNLQRHIRSQHVGARAHACPECGKTFATSSGLKQHKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMH
ADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHFAAGGFFGQGISLPGTPAMDKTSMVNMSHANPGLADYFGANRHPAGLTFPTAPGFS
FSFPGLFPSGLYHRPPLIPASSPVKGLSSTEQTNKSQSPLMTHPQILPATQDILKALSKHPSVGDNKPVELQPERSSEERPFEKISDQSE
SSDLDDVSTPSGSDLETTSGSDLESDIESDKEKFKENGKMFKDKVSPLQNLASINNKKEYSNHSIFSPSLEEQTAVSGAVNDSIKAIASI
AEKYFGSTGLVGLQDKKVGALPYPSMFPLPFFPAFSQSMYPFPDRDLRSLPLKMEPQSPGEVKKLQKGSSESPFDLTTKRKDEKPLTPVP
SKPPVTPATSQDQPLDLSMGSRSRASGTKLTEPRKNHVFGGKKGSNVESRPASDGSLQHARPTPFFMDPIYRVEKRKLTDPLEALKEKYL
RPSPGFLFHPQFQLPDQRTWMSAIENMAEKLESFSALKPEASELLQSVPSMFNFRAPPNALPENLLRKGKERYTCRYCGKIFPRSANLTR
HLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCDRCFGQQTNLDRHLKKHENGNMSGTATSSPHSELESTGAILDDKE
DAYFTEIRNFIGNSNHGSQSPRNVEERMNGSHFKDEKALVTSQNSDLLDDEEVEDEVLLDEEDEDNDITGKTGKEPVTSNLHEGNPEDDY
EETSALEMSCKTSPVRYKEEEYKSGLSALDHIRHFTDSLKMRKMEDNQYSEAELSSFSTSHVPEELKQPLHRKSKSQAYAMMLSLSDKES

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Fusion Gene PPI Analysis for GOLIM4-MECOM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneMECOMchr3:167742314chr3:168861620ENST00000264674117189_4401.01117.0MAPK9%2C SMAD3 and probably SUV39H1
TgeneMECOMchr3:167742314chr3:168861620ENST00000392736016189_44001052.0MAPK9%2C SMAD3 and probably SUV39H1
TgeneMECOMchr3:167742314chr3:168861620ENST00000433243117189_44001053.0MAPK9%2C SMAD3 and probably SUV39H1
TgeneMECOMchr3:167742314chr3:168861620ENST00000464456015189_44001043.0MAPK9%2C SMAD3 and probably SUV39H1
TgeneMECOMchr3:167742314chr3:168861620ENST00000468789016189_44001052.0MAPK9%2C SMAD3 and probably SUV39H1
TgeneMECOMchr3:167742314chr3:168861620ENST00000472280016189_44001053.0MAPK9%2C SMAD3 and probably SUV39H1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GOLIM4-MECOM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GOLIM4-MECOM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource