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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GOLIM4-OSBPL1A (FusionGDB2 ID:33950)

Fusion Gene Summary for GOLIM4-OSBPL1A

Fusion gene summary

Fusion gene information	Fusion gene name: GOLIM4-OSBPL1A
	Fusion gene ID: 33950
		Hgene	Tgene
	Gene symbol	GOLIM4	OSBPL1A
	Gene ID	27333	114876
	Gene name	golgi integral membrane protein 4	oxysterol binding protein like 1A
	Synonyms	GIMPC\|GOLPH4\|GPP130\|P138	ORP-1\|ORP1\|OSBPL1B
	Cytomap	3q26.2	18q11.2
	Type of gene	protein-coding	protein-coding
	Description	Golgi integral membrane protein 4130 kDa golgi-localized phosphoproteincis Golgi-localized calcium-binding proteingolgi integral membrane protein, cisgolgi phosphoprotein 4golgi phosphoprotein of 130 kDagolgi-localized phosphoprotein of 130 kDatype	oxysterol-binding protein-related protein 1OSBP-related protein 1oxysterol binding protein-like 1Boxysterol-binding protein-related protein 1 variant 1oxysterol-binding protein-related protein 1 variant 2
	Modification date	20200313	20200313
	UniProtAcc	O00461	.
	Ensembl transtripts involved in fusion gene	ENST00000309027, ENST00000470487,	ENST00000357041, ENST00000399443, ENST00000399441, ENST00000582618, ENST00000319481,
Fusion gene scores	* DoF score	14 X 11 X 10=1540	18 X 15 X 10=2700
	# samples	18	19
	** MAII score	log2(18/1540*10)=-3.09686153925259 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(19/2700*10)=-3.82888808360725 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GOLIM4 [Title/Abstract] AND OSBPL1A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GOLIM4(167742314)-OSBPL1A(21819346), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across GOLIM4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across OSBPL1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-D7-8574-01A	GOLIM4	chr3	167742314	-	OSBPL1A	chr18	21819346	-

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Fusion Gene ORF analysis for GOLIM4-OSBPL1A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000309027	ENST00000357041	GOLIM4	chr3	167742314	-	OSBPL1A	chr18	21819346	-
5CDS-5UTR	ENST00000309027	ENST00000399443	GOLIM4	chr3	167742314	-	OSBPL1A	chr18	21819346	-
5CDS-5UTR	ENST00000470487	ENST00000357041	GOLIM4	chr3	167742314	-	OSBPL1A	chr18	21819346	-
5CDS-5UTR	ENST00000470487	ENST00000399443	GOLIM4	chr3	167742314	-	OSBPL1A	chr18	21819346	-
5CDS-intron	ENST00000309027	ENST00000399441	GOLIM4	chr3	167742314	-	OSBPL1A	chr18	21819346	-
5CDS-intron	ENST00000309027	ENST00000582618	GOLIM4	chr3	167742314	-	OSBPL1A	chr18	21819346	-
5CDS-intron	ENST00000470487	ENST00000399441	GOLIM4	chr3	167742314	-	OSBPL1A	chr18	21819346	-
5CDS-intron	ENST00000470487	ENST00000582618	GOLIM4	chr3	167742314	-	OSBPL1A	chr18	21819346	-
In-frame	ENST00000309027	ENST00000319481	GOLIM4	chr3	167742314	-	OSBPL1A	chr18	21819346	-
In-frame	ENST00000470487	ENST00000319481	GOLIM4	chr3	167742314	-	OSBPL1A	chr18	21819346	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000470487	GOLIM4	chr3	167742314	-	ENST00000319481	OSBPL1A	chr18	21819346	-	5257	2550	672	4121	1149
ENST00000309027	GOLIM4	chr3	167742314	-	ENST00000319481	OSBPL1A	chr18	21819346	-	4542	1835	41	3406	1121

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000470487	ENST00000319481	GOLIM4	chr3	167742314	-	OSBPL1A	chr18	21819346	-	0.00229771	0.9977023
ENST00000309027	ENST00000319481	GOLIM4	chr3	167742314	-	OSBPL1A	chr18	21819346	-	0.001355802	0.9986442

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Fusion Genomic Features for GOLIM4-OSBPL1A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GOLIM4-OSBPL1A

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:167742314/chr18:21819346)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GOLIM4 O00461	.
FUNCTION: Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi. {ECO:0000269\|PubMed:15331763}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GOLIM4

chr3:167742314

chr18:21819346

ENST00000470487

35_244

620

697.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

GOLIM4

chr3:167742314

chr18:21819346

ENST00000470487

404_513

620

697.0

Compositional bias

Note=Gln-rich

Hgene

GOLIM4

chr3:167742314

chr18:21819346

ENST00000470487

176_248

620

697.0

Region

Note=Golgi targeting

Hgene

GOLIM4

chr3:167742314

chr18:21819346

ENST00000470487

38_107

620

697.0

Region

Note=Golgi targeting

Hgene

GOLIM4

chr3:167742314

chr18:21819346

ENST00000470487

80_175

620

697.0

Region

Note=Endosome targeting

Hgene

GOLIM4

chr3:167742314

chr18:21819346

ENST00000470487

2_12

620

697.0

Topological domain

Cytoplasmic

Hgene

GOLIM4

chr3:167742314

chr18:21819346

ENST00000470487

13_33

620

697.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

OSBPL1A

chr3:167742314

chr18:21819346

ENST00000319481

430_463

427

951.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

OSBPL1A

chr3:167742314

chr18:21819346

ENST00000319481

877_913

427

951.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

OSBPL1A

chr3:167742314

chr18:21819346

ENST00000357041

430_463

569.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

OSBPL1A

chr3:167742314

chr18:21819346

ENST00000357041

877_913

569.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

OSBPL1A

chr3:167742314

chr18:21819346

ENST00000399443

430_463

438.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

OSBPL1A

chr3:167742314

chr18:21819346

ENST00000399443

877_913

438.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

OSBPL1A

chr3:167742314

chr18:21819346

ENST00000357041

235_334

569.0

Domain

Tgene

OSBPL1A

chr3:167742314

chr18:21819346

ENST00000399443

235_334

438.0

Domain

Tgene

OSBPL1A

chr3:167742314

chr18:21819346

ENST00000319481

469_483

427

951.0

Motif

FFAT

Tgene

OSBPL1A

chr3:167742314

chr18:21819346

ENST00000357041

469_483

569.0

Motif

FFAT

Tgene

OSBPL1A

chr3:167742314

chr18:21819346

ENST00000399443

469_483

438.0

Motif

FFAT

Tgene

OSBPL1A

chr3:167742314

chr18:21819346

ENST00000357041

175_204

569.0

Repeat

Note=ANK 3

Tgene

OSBPL1A

chr3:167742314

chr18:21819346

ENST00000357041

47_76

569.0

Repeat

Note=ANK 1

Tgene

OSBPL1A

chr3:167742314

chr18:21819346

ENST00000357041

80_109

569.0

Repeat

Note=ANK 2

Tgene

OSBPL1A

chr3:167742314

chr18:21819346

ENST00000399443

175_204

438.0

Repeat

Note=ANK 3

Tgene

OSBPL1A

chr3:167742314

chr18:21819346

ENST00000399443

47_76

438.0

Repeat

Note=ANK 1

Tgene

OSBPL1A

chr3:167742314

chr18:21819346

ENST00000399443

80_109

438.0

Repeat

Note=ANK 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GOLIM4

chr3:167742314

chr18:21819346

ENST00000470487

311_681

620

697.0

Compositional bias

Note=Glu-rich

Hgene

GOLIM4

chr3:167742314

chr18:21819346

ENST00000470487

34_696

620

697.0

Topological domain

Lumenal

Tgene

OSBPL1A

chr3:167742314

chr18:21819346

ENST00000319481

235_334

427

951.0

Domain

Tgene

OSBPL1A

chr3:167742314

chr18:21819346

ENST00000319481

175_204

427

951.0

Repeat

Note=ANK 3

Tgene

OSBPL1A

chr3:167742314

chr18:21819346

ENST00000319481

47_76

427

951.0

Repeat

Note=ANK 1

Tgene

OSBPL1A

chr3:167742314

chr18:21819346

ENST00000319481

80_109

427

951.0

Repeat

Note=ANK 2

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Fusion Gene Sequence for GOLIM4-OSBPL1A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>33950_33950_1_GOLIM4-OSBPL1A_GOLIM4_chr3_167742314_ENST00000309027_OSBPL1A_chr18_21819346_ENST00000319481_length(transcript)=4542nt_BP=1835nt
GCTCGGACCAAGGGGAGGAGACGGCGGGGGCGGCCGCGGCTTTGGGTCCAGGCGGGACTATGGGAAACGGGATGTGCTCCCGAAAGCAGA
AGCGGATTTTCCAGACGCTGCTGCTGCTGACCGTCGTGTTCGGCTTTCTCTACGGCGCGATGCTCTACTACGAGCTGCAGACGCAGCTGC
GGAAAGCCGAGGCGGTGGCGCTCAAGTACCAGCAGCACCAGGAGTCCCTCTCCGCCCAGTTACAAGTTGTATATGAACACAGATCAAGAT
TAGAGAAATCCTTGCAAAAAGAAAGACTTGAACATAAAAAAGCAAAGGAAGATTTTCTTGTTTATAAGTTAGAAGCACAAGAAACATTAA
ATAAAGGAAGGCAAGATTCCAATAGCAGATACAGTGCACTGAATGTCCAACATCAGATGTTGAAAAGCCAACACGAGGAGCTAAAGAAAC
AGCACAGTGACTTGGAAGAGGAACATCGCAAACAAGGGGAAGACTTCAGTAGAACATTTAATGACCATAAGCAAAAATACTTGCAGCTCC
AGCAAGAAAAAGAACAAGAACTTTCTAAGCTAAAAGAGACTGTATACAATTTGAGAGAAGAGAATAGACAACTAAGGAAAGCACACCAAG
ACATACATACACAGCTTCAAGATGTCAAGACTCAAGTTGCAGAATATAAACAACTGAAAGATACTCTGAATAGGATTCCAAGCCTTCGAA
AACCTGATCCAGCAGAACAGCAAAATGTGACCCAGGTGGCACATTCTCCACAAGGTTACAACACAGCAAGGGAGAAGCCAACCCGAGAGG
TGCAGGAGGTGTCTCGAAATAATGATGTGTGGCAGAACCATGAAGCAGTTCCTGGAAGAGCAGAAGACACAAAACTCTATGCTCCCACCC
ATAAGGAGGCAGAATTTCAGGCTCCCCCAGAGCCAATCCAACAAGAAGTGGAACGCAGAGAACCTGAGGAGCATCAGGTGGAAGAGGAGC
ACAGAAAGGCCCTGGAGGAGGAAGAAATGGAGCAGGTCGGGCAAGCAGAACATCTTGAGGAGGAACACGATCCATCACCAGAGGAGCAGG
ATCGGGAGTGGAAAGAGCAGCATGAGCAACGAGAAGCAGCCAACCTCCTGGAAGGGCACGCGCGTGCTGAGGTGTACCCTTCAGCCAAGC
CAATGATCAAATTCCAATCACCCTATGAGGAACAGTTGGAACAGCAGAGACTGGCAGTGCAGCAGGTGGAGGAGGCCCAGCAGCTGCGGG
AACACCAGGAAGCTTTGCACCAGCAGAGGCTGCAGGGGCACTTACTACGGCAGCAGGAACAGCAGCAGCAGCAGGTGGCAAGAGAGATGG
CCCTGCAGAGGCAGGCTGAGCTTGAGGAGGGCCGGCCGCAGCACCAGGAGCAGCTCCGGCAGCAAGCTCATTATGATGCTATGGATAATG
ATATCGTTCAGGGAGCAGAGGACCAGGGAATCCAAGGAGAGGAAGGAGCCTATGAAAGAGACAACCAGCACCAAGATGAAGCAGAAGGAG
ATCCAGGTAATAGACATGAGCCTCGTGAACAAGGACCCCGAGAAGCCGACCCAGAATCTGAGGCAGATAGGGCAGCTGTAGAAGATATAA
ACCCAGCAGATGACCCTAATAATCAAGGTGAGGATGAATTTGAAGAAGCCGAGCAAGTGAGAGAAGAAAATTTGCCAGATGAAAATGAAG
AGCAAAAACAAAGTAATCAAAAGCAAGAGAATACAGAAGTGGAGGAACATTTGGTGATGGCAGGAAATCCAGACCAGCAGGAGGACAATG
TTGATGAACAGTACCAGGAAGAGGCAGAAGAGGAGGTGAGGAATTTTAAATTGGAACAAGAGCAAGAAAAAAACAAAATCTTGTCAGAAG
CACTGGAGACGCTGGCCACTGAACATCATGAATTAGAGCAGTCTCTGGTGAAAGGCTCTCCACCCGCCAGCATCCTTAGCGAGGACGAGT
TCTATGATGCGCTGTCAGATTCCGAGTCCGAAAGGTCCCTGAGTAGATTGGAAGCAGTGACAGCACGCTCCTTTGAAGAGGAAGGAGAGC
ATTTGGGCAGTAGAAAACACAGAATGTCCGAAGAAAAAGACTGTGGTGGCGGAGATGCTCTCTCCAATGGCATCAAGAAACACAGAACAA
GTTTGCCTTCTCCTATGTTTTCCAGAAATGACTTCAGTATCTGGAGCATCCTCAGAAAATGTATTGGAATGGAACTATCCAAGATCACGA
TGCCAGTTATATTTAATGAGCCTCTGAGCTTCCTACAGCGCCTAACTGAATACATGGAGCATACTTACCTCATCCACAAGGCCAGTTCAC
TCTCTGATCCTGTGGAAAGGATGCAGTGTGTAGCTGCGTTTGCTGTATCTGCTGTTGCTTCTCAGTGGGAACGGACTGGAAAACCTTTCA
ACCCACTGCTGGGAGAGACTTATGAATTAGTGCGAGATGACCTTGGATTTAGACTCATCTCCGAACAGGTCAGCCATCACCCACCAATCA
GTGCATTTCATGCTGAAGGATTAAACAATGACTTCATCTTTCATGGCTCTATCTATCCCAAACTGAAATTCTGGGGGAAGAGTGTAGAAG
CAGAACCCAAAGGAACCATCACCTTGGAGCTCCTTGAACACAATGAGGCATATACATGGACAAATCCCACCTGCTGTGTGCATAATATCA
TTGTGGGTAAACTGTGGATCGAACAGTATGGCAATGTGGAAATTATAAACCACAAGACTGGGGACAAATGTGTGTTGAATTTTAAGCCAT
GTGGCCTTTTTGGTAAGGAATTACACAAAGTTGAAGGCTACATTCAAGATAAAAGCAAAAAGAAGCTCTGTGCCCTCTATGGGAAGTGGA
CTGAATGTTTATACAGTGTTGACCCTGCCACGTTTGACGCTTACAAAAAAAATGATAAGAAAAATACAGAAGAGAAGAAGAACAGCAAAC
AGATGAGCACCTCTGAGGAGTTGGATGAAATGCCAGTGCCGGATTCTGAAAGTGTATTCATTATCCCTGGAAGCGTTCTTCTATGGCGAA
TAGCCCCACGGCCTCCAAATTCTGCCCAGATGTATAATTTTACTAGTTTTGCAATGGTTTTGAATGAAGTAGACAAAGACATGGAGAGTG
TGATTCCCAAGACAGACTGCAGGTTACGGCCTGACATCAGAGCCATGGAAAATGGAGAGATAGATCAAGCTAGTGAAGAAAAAAAACGAC
TTGAGGAAAAACAAAGAGCAGCCCGCAAAAACAGGTCCAAGTCAGAAGAGGACTGGAAGACGAGGTGGTTCCATCAAGGTCCTAATCCCT
ACAATGGAGCACAGGACTGGATTTACTCTGGCAGCTACTGGGACAGAAATTACTTCAATTTGCCTGACATTTATTAAAATGCATACAAGT
CAGGGTGTTTGGCTAATCTACAAATAAGTCTTAAACCTATGTTTTTAAATTTTTTTCCCTTGGTTTCTACTTATCTTTTAAAAAAAAAAA
TGAAAAAACACTCATGAGATAACTGCATTTCACCCAACAAAAGCAGGGTATAAGGCGATATTGGTGATGAAAGTCTTAGGAAAAATGCAT
AATTTTGCTATAAAATGTACTTATTTGGAATACTATTTTATATAGAGGTAAGAGAACACTGCTGGGGAATATGCTTTTTATGGTTGCTGT
TGCCATATTTACTGAAGGTTTATACCTAAATGTAACTTTAGCTTTATGGAACTATATAGTAATCCCAAATCAAGTTATTTTGAATATTTT
TATGCTGTCATGCTTGAATGTTTTAGATGTAACCTTTGACATATTTAGAACTCTCCTCCTATACAATGTTTATTCTCAGATATAGAGGTT
ATGTCATTTTATAAAGACTTCATTGATAAGATGGCTTTTATTCATACTAATCCTCCCAATGTTACCCCTTCCATCTTCCAAGAAGAAAAA
AAATGCCTGAATATTCAGAATAGATATTTCTGATTTGAAAATTCTAAAGAATTAAACTGGAAAAGTATTTCATTTACTTAGTGCTCTGAA
TTTACTTTTACAGTTTTCTGCAGTCAGTATCATTAAAATGGTTAAGTTTACATTTGAACTGAAAATATGTATAAAATCTAGCAATTCACA
AAAATGCCCTAGAAATATAGATTTTAATCACCATTACATAATGACAAACCTTGTTAAATGCTTCCACTTCCAGTGGCAAATGCCACTAGG
GAAAGTAAGTTGCACTCATGTAAGTATCAAACTATATAAAAGGAGGCCTTGTGCATTTCAAGTTTGCAAAGTACCTGTGTACTTAAAATA
TGTGTGGAGACCTACTGTACAGTAGTTTTGCCCCTTTAATTGGGGCACATTCATCTTAAATCTTATAGTATTTATCCACCCAAACCCCAG
ACTGAGATACTGCTCCCAGGGGCCTAGGTAGCTGCCAGTCCGTGATTTTAATTGCTGTCTTGAAGTTAACAAGTGTTATAATGAAATAAT

>33950_33950_1_GOLIM4-OSBPL1A_GOLIM4_chr3_167742314_ENST00000309027_OSBPL1A_chr18_21819346_ENST00000319481_length(amino acids)=1121AA_BP=598
MGPGGTMGNGMCSRKQKRIFQTLLLLTVVFGFLYGAMLYYELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKK
AKEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYLQLQQEKEQELSKLKET
VYNLREENRQLRKAHQDIHTQLQDVKTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNH
EAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAA
NLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQ
HQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVEDINPADDPNNQGEDEF
EEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEVRNFKLEQEQEKNKILSEALETLATEHHELEQ
SLVKGSPPASILSEDEFYDALSDSESERSLSRLEAVTARSFEEEGEHLGSRKHRMSEEKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSI
WSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSAVASQWERTGKPFNPLLGETYELVRDD
LGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVE
IINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKKNTEEKKNSKQMSTSEELDEMPVP
DSESVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRSK

--------------------------------------------------------------
>33950_33950_2_GOLIM4-OSBPL1A_GOLIM4_chr3_167742314_ENST00000470487_OSBPL1A_chr18_21819346_ENST00000319481_length(transcript)=5257nt_BP=2550nt
AATGAGCAAGGAGGCCGAGTGGGACTTCCTCCCGGAATCCCGTTGGCCAGAATAGCCGGGCCGTGGGTGACACGTAAGTTGGGCAGGAGG
TGGCGGGGCGGCAGAGGCACCAGCCGACCCGTCAGTGACACCGCTGTGCCGTCCCCAAAACCAGCCGAGACAGCTGGCCCCCACCCTTCC
ACCCATTGGGCAGGCCGCACGGGGGCGCGGCCCGGAGTCCTGGTCCCTTTGTTGGGCGCGCACCCCCTCCCTTAGGTGGCAACAAAGTCG
TGCAGTGGGAGCCGCCGCGATAGGGCGGGGAGTGGCCAGGGCGGGACTCCAAGAACTGCCCGGGGGCAGCGGGGCCAAAAAGTGGGAAGA
AGGAAAAAAGGCAGGAGGCATCTGGGGACAGGCGCGAGGGCAGCCGGCTCTGAAGTATGCGGAGGGCCTCCTCCCGGCCCCGGGCATTCG
CGGAGAACGAGCCTCGCAGAAGTTTGGCTGCAGCTGCCCGGGCGGCGTCGATGGCTGCGCGCCCCGCGCCGCGCGGGGGCTGAGCGGGCG
CCACTTCCCCTCCGGGCCGGCTTTTGTGTCTGGCATCTCCTCCTCATGCTGCGTCTGGCCACCTACTGCGGCGGCCGCTGCTGAGACGCT
CGCTCGGACCAAGGGGAGGAGACGGCGGGGGCGGCCGCGGCTTTGGGTCCAGGCGGGACTATGGGAAACGGGATGTGCTCCCGAAAGCAG
AAGCGGATTTTCCAGACGCTGCTGCTGCTGACCGTCGTGTTCGGCTTTCTCTACGGCGCGATGCTCTACTACGAGCTGCAGACGCAGCTG
CGGAAAGCCGAGGCGGTGGCGCTCAAGTACCAGCAGCACCAGGAGTCCCTCTCCGCCCAGTTACAAGTTGTATATGAACACAGATCAAGA
TTAGAGAAATCCTTGCAAAAAGAAAGACTTGAACATAAAAAAGCAAAGGAAGATTTTCTTGTTTATAAGTTAGAAGCACAAGAAACATTA
AATAAAGGAAGGCAAGATTCCAATAGCAGATACAGTGCACTGAATGTCCAACATCAGATGTTGAAAAGCCAACACGAGGAGCTAAAGAAA
CAGCACAGTGACTTGGAAGAGGAACATCGCAAACAAGGGGAAGACTTCAGTAGAACATTTAATGACCATAAGCAAAAATACTTGCAGCTC
CAGCAAGAAAAAGAACAAGAACTTTCTAAGCTAAAAGAGACTGTATACAATTTGAGAGAAGAGAATAGACAACTAAGGAAAGCACACCAA
GACATACATACACAGCTTCAAGATGTCAAGCAACAGCATAAGAATTTACTCTCCGAGCATGAACAACTTGTAGTGACTTTGGAAGACCAC
AAGAGTGCACTAGCTGCTGCACAGACTCAAGTTGCAGAATATAAACAACTGAAAGATACTCTGAATAGGATTCCAAGCCTTCGAAAACCT
GATCCAGCAGAACAGCAAAATGTGACCCAGGTGGCACATTCTCCACAAGGTTACAACACAGCAAGGGAGAAGCCAACCCGAGAGGTGCAG
GAGGTGTCTCGAAATAATGATGTGTGGCAGAACCATGAAGCAGTTCCTGGAAGAGCAGAAGACACAAAACTCTATGCTCCCACCCATAAG
GAGGCAGAATTTCAGGCTCCCCCAGAGCCAATCCAACAAGAAGTGGAACGCAGAGAACCTGAGGAGCATCAGGTGGAAGAGGAGCACAGA
AAGGCCCTGGAGGAGGAAGAAATGGAGCAGGTCGGGCAAGCAGAACATCTTGAGGAGGAACACGATCCATCACCAGAGGAGCAGGATCGG
GAGTGGAAAGAGCAGCATGAGCAACGAGAAGCAGCCAACCTCCTGGAAGGGCACGCGCGTGCTGAGGTGTACCCTTCAGCCAAGCCAATG
ATCAAATTCCAATCACCCTATGAGGAACAGTTGGAACAGCAGAGACTGGCAGTGCAGCAGGTGGAGGAGGCCCAGCAGCTGCGGGAACAC
CAGGAAGCTTTGCACCAGCAGAGGCTGCAGGGGCACTTACTACGGCAGCAGGAACAGCAGCAGCAGCAGGTGGCAAGAGAGATGGCCCTG
CAGAGGCAGGCTGAGCTTGAGGAGGGCCGGCCGCAGCACCAGGAGCAGCTCCGGCAGCAAGCTCATTATGATGCTATGGATAATGATATC
GTTCAGGGAGCAGAGGACCAGGGAATCCAAGGAGAGGAAGGAGCCTATGAAAGAGACAACCAGCACCAAGATGAAGCAGAAGGAGATCCA
GGTAATAGACATGAGCCTCGTGAACAAGGACCCCGAGAAGCCGACCCAGAATCTGAGGCAGATAGGGCAGCTGTAGAAGATATAAACCCA
GCAGATGACCCTAATAATCAAGGTGAGGATGAATTTGAAGAAGCCGAGCAAGTGAGAGAAGAAAATTTGCCAGATGAAAATGAAGAGCAA
AAACAAAGTAATCAAAAGCAAGAGAATACAGAAGTGGAGGAACATTTGGTGATGGCAGGAAATCCAGACCAGCAGGAGGACAATGTTGAT
GAACAGTACCAGGAAGAGGCAGAAGAGGAGGTGAGGAATTTTAAATTGGAACAAGAGCAAGAAAAAAACAAAATCTTGTCAGAAGCACTG
GAGACGCTGGCCACTGAACATCATGAATTAGAGCAGTCTCTGGTGAAAGGCTCTCCACCCGCCAGCATCCTTAGCGAGGACGAGTTCTAT
GATGCGCTGTCAGATTCCGAGTCCGAAAGGTCCCTGAGTAGATTGGAAGCAGTGACAGCACGCTCCTTTGAAGAGGAAGGAGAGCATTTG
GGCAGTAGAAAACACAGAATGTCCGAAGAAAAAGACTGTGGTGGCGGAGATGCTCTCTCCAATGGCATCAAGAAACACAGAACAAGTTTG
CCTTCTCCTATGTTTTCCAGAAATGACTTCAGTATCTGGAGCATCCTCAGAAAATGTATTGGAATGGAACTATCCAAGATCACGATGCCA
GTTATATTTAATGAGCCTCTGAGCTTCCTACAGCGCCTAACTGAATACATGGAGCATACTTACCTCATCCACAAGGCCAGTTCACTCTCT
GATCCTGTGGAAAGGATGCAGTGTGTAGCTGCGTTTGCTGTATCTGCTGTTGCTTCTCAGTGGGAACGGACTGGAAAACCTTTCAACCCA
CTGCTGGGAGAGACTTATGAATTAGTGCGAGATGACCTTGGATTTAGACTCATCTCCGAACAGGTCAGCCATCACCCACCAATCAGTGCA
TTTCATGCTGAAGGATTAAACAATGACTTCATCTTTCATGGCTCTATCTATCCCAAACTGAAATTCTGGGGGAAGAGTGTAGAAGCAGAA
CCCAAAGGAACCATCACCTTGGAGCTCCTTGAACACAATGAGGCATATACATGGACAAATCCCACCTGCTGTGTGCATAATATCATTGTG
GGTAAACTGTGGATCGAACAGTATGGCAATGTGGAAATTATAAACCACAAGACTGGGGACAAATGTGTGTTGAATTTTAAGCCATGTGGC
CTTTTTGGTAAGGAATTACACAAAGTTGAAGGCTACATTCAAGATAAAAGCAAAAAGAAGCTCTGTGCCCTCTATGGGAAGTGGACTGAA
TGTTTATACAGTGTTGACCCTGCCACGTTTGACGCTTACAAAAAAAATGATAAGAAAAATACAGAAGAGAAGAAGAACAGCAAACAGATG
AGCACCTCTGAGGAGTTGGATGAAATGCCAGTGCCGGATTCTGAAAGTGTATTCATTATCCCTGGAAGCGTTCTTCTATGGCGAATAGCC
CCACGGCCTCCAAATTCTGCCCAGATGTATAATTTTACTAGTTTTGCAATGGTTTTGAATGAAGTAGACAAAGACATGGAGAGTGTGATT
CCCAAGACAGACTGCAGGTTACGGCCTGACATCAGAGCCATGGAAAATGGAGAGATAGATCAAGCTAGTGAAGAAAAAAAACGACTTGAG
GAAAAACAAAGAGCAGCCCGCAAAAACAGGTCCAAGTCAGAAGAGGACTGGAAGACGAGGTGGTTCCATCAAGGTCCTAATCCCTACAAT
GGAGCACAGGACTGGATTTACTCTGGCAGCTACTGGGACAGAAATTACTTCAATTTGCCTGACATTTATTAAAATGCATACAAGTCAGGG
TGTTTGGCTAATCTACAAATAAGTCTTAAACCTATGTTTTTAAATTTTTTTCCCTTGGTTTCTACTTATCTTTTAAAAAAAAAAATGAAA
AAACACTCATGAGATAACTGCATTTCACCCAACAAAAGCAGGGTATAAGGCGATATTGGTGATGAAAGTCTTAGGAAAAATGCATAATTT
TGCTATAAAATGTACTTATTTGGAATACTATTTTATATAGAGGTAAGAGAACACTGCTGGGGAATATGCTTTTTATGGTTGCTGTTGCCA
TATTTACTGAAGGTTTATACCTAAATGTAACTTTAGCTTTATGGAACTATATAGTAATCCCAAATCAAGTTATTTTGAATATTTTTATGC
TGTCATGCTTGAATGTTTTAGATGTAACCTTTGACATATTTAGAACTCTCCTCCTATACAATGTTTATTCTCAGATATAGAGGTTATGTC
ATTTTATAAAGACTTCATTGATAAGATGGCTTTTATTCATACTAATCCTCCCAATGTTACCCCTTCCATCTTCCAAGAAGAAAAAAAATG
CCTGAATATTCAGAATAGATATTTCTGATTTGAAAATTCTAAAGAATTAAACTGGAAAAGTATTTCATTTACTTAGTGCTCTGAATTTAC
TTTTACAGTTTTCTGCAGTCAGTATCATTAAAATGGTTAAGTTTACATTTGAACTGAAAATATGTATAAAATCTAGCAATTCACAAAAAT
GCCCTAGAAATATAGATTTTAATCACCATTACATAATGACAAACCTTGTTAAATGCTTCCACTTCCAGTGGCAAATGCCACTAGGGAAAG
TAAGTTGCACTCATGTAAGTATCAAACTATATAAAAGGAGGCCTTGTGCATTTCAAGTTTGCAAAGTACCTGTGTACTTAAAATATGTGT
GGAGACCTACTGTACAGTAGTTTTGCCCCTTTAATTGGGGCACATTCATCTTAAATCTTATAGTATTTATCCACCCAAACCCCAGACTGA
GATACTGCTCCCAGGGGCCTAGGTAGCTGCCAGTCCGTGATTTTAATTGCTGTCTTGAAGTTAACAAGTGTTATAATGAAATAATCTACC

>33950_33950_2_GOLIM4-OSBPL1A_GOLIM4_chr3_167742314_ENST00000470487_OSBPL1A_chr18_21819346_ENST00000319481_length(amino acids)=1149AA_BP=626
MGPGGTMGNGMCSRKQKRIFQTLLLLTVVFGFLYGAMLYYELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKK
AKEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYLQLQQEKEQELSKLKET
VYNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHS
PQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQA
EHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLL
RQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREA
DPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEVRNF
KLEQEQEKNKILSEALETLATEHHELEQSLVKGSPPASILSEDEFYDALSDSESERSLSRLEAVTARSFEEEGEHLGSRKHRMSEEKDCG
GGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAV
SAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNE
AYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAYK
KNDKKNTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCRLRPDIRAM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GOLIM4-OSBPL1A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	OSBPL1A	chr3:167742314	chr18:21819346	ENST00000399443		0	14	1_237	0	438.0	RAB7A

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	OSBPL1A	chr3:167742314	chr18:21819346	ENST00000319481		14	28	1_237	427.0	951.0	RAB7A
Tgene	OSBPL1A	chr3:167742314	chr18:21819346	ENST00000357041		2	16	1_237	45.0	569.0	RAB7A

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for GOLIM4-OSBPL1A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for GOLIM4-OSBPL1A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source