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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GOLPH3-CMIP (FusionGDB2 ID:33964)

Fusion Gene Summary for GOLPH3-CMIP

Fusion gene summary

Fusion gene information	Fusion gene name: GOLPH3-CMIP
	Fusion gene ID: 33964
		Hgene	Tgene
	Gene symbol	GOLPH3	CMIP
	Gene ID	64083	80790
	Gene name	golgi phosphoprotein 3	c-Maf inducing protein
	Synonyms	GOPP1\|GPP34\|MIDAS\|Vps74	TCMIP
	Cytomap	5p13.3	16q23.2-q23.3
	Type of gene	protein-coding	protein-coding
	Description	Golgi phosphoprotein 3coat protein GPP34coat-proteingolgi peripheral membrane protein 1, 34 kDagolgi proteingolgi-associated proteinmitochondrial DNA absence factor	C-Maf-inducing proteintc-Mip
	Modification date	20200329	20200313
	UniProtAcc	Q9H4A6	Q8IY22
	Ensembl transtripts involved in fusion gene	ENST00000265070, ENST00000512668,	ENST00000398040, ENST00000566513, ENST00000537098, ENST00000539778,
Fusion gene scores	* DoF score	11 X 10 X 7=770	6 X 7 X 3=126
	# samples	16	7
	** MAII score	log2(16/770*10)=-2.2667865406949 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GOLPH3 [Title/Abstract] AND CMIP [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GOLPH3(32173916)-CMIP(81641172), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GOLPH3	GO:0010821	regulation of mitochondrion organization	16263763

Fusion gene breakpoints across GOLPH3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CMIP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-8366-01A	GOLPH3	chr5	32173916	-	CMIP	chr16	81641172	+

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Fusion Gene ORF analysis for GOLPH3-CMIP

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000265070	ENST00000398040	GOLPH3	chr5	32173916	-	CMIP	chr16	81641172	+
5CDS-intron	ENST00000265070	ENST00000566513	GOLPH3	chr5	32173916	-	CMIP	chr16	81641172	+
5UTR-3CDS	ENST00000512668	ENST00000537098	GOLPH3	chr5	32173916	-	CMIP	chr16	81641172	+
5UTR-3CDS	ENST00000512668	ENST00000539778	GOLPH3	chr5	32173916	-	CMIP	chr16	81641172	+
5UTR-intron	ENST00000512668	ENST00000398040	GOLPH3	chr5	32173916	-	CMIP	chr16	81641172	+
5UTR-intron	ENST00000512668	ENST00000566513	GOLPH3	chr5	32173916	-	CMIP	chr16	81641172	+
In-frame	ENST00000265070	ENST00000537098	GOLPH3	chr5	32173916	-	CMIP	chr16	81641172	+
In-frame	ENST00000265070	ENST00000539778	GOLPH3	chr5	32173916	-	CMIP	chr16	81641172	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000265070

GOLPH3

chr5

32173916

ENST00000537098

CMIP

chr16

81641172

4526

541

316

2562

748

ENST00000265070

GOLPH3

chr5

32173916

ENST00000539778

CMIP

chr16

81641172

4332

541

316

2562

748

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000265070	ENST00000537098	GOLPH3	chr5	32173916	-	CMIP	chr16	81641172	+	0.001239887	0.9987601
ENST00000265070	ENST00000539778	GOLPH3	chr5	32173916	-	CMIP	chr16	81641172	+	0.002061646	0.99793833

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Fusion Genomic Features for GOLPH3-CMIP

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
GOLPH3	chr5	32173915	-	CMIP	chr16	81641171	+	6.43E-18	1
GOLPH3	chr5	32173915	-	CMIP	chr16	81641171	+	6.43E-18	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GOLPH3-CMIP

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:32173916/chr16:81641172)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GOLPH3 Q9H4A6	CMIP Q8IY22
FUNCTION: Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis. {ECO:0000269\|PubMed:16263763, ECO:0000269\|PubMed:19553991, ECO:0000269\|PubMed:19837035, ECO:0000269\|PubMed:22745132, ECO:0000269\|PubMed:23027862, ECO:0000269\|PubMed:23345592, ECO:0000269\|PubMed:23500462}.	FUNCTION: Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor. {ECO:0000269\|PubMed:12939343, ECO:0000269\|PubMed:15128042}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GOLPH3

chr5:32173916

chr16:81641172

ENST00000265070

48_51

299.0

Compositional bias

Note=Poly-Asp

Tgene

CMIP

chr5:32173916

chr16:81641172

ENST00000398040

54_163

621.0

Domain

Note=PH

Tgene

CMIP

chr5:32173916

chr16:81641172

ENST00000539778

54_163

680.0

Domain

Note=PH

Tgene

CMIP

chr5:32173916

chr16:81641172

ENST00000398040

663_686

621.0

Repeat

Note=LRR 1

Tgene

CMIP

chr5:32173916

chr16:81641172

ENST00000398040

687_707

621.0

Repeat

Note=LRR 2

Tgene

CMIP

chr5:32173916

chr16:81641172

ENST00000398040

712_732

621.0

Repeat

Note=LRR 3

Tgene

CMIP

chr5:32173916

chr16:81641172

ENST00000398040

736_756

621.0

Repeat

Note=LRR 4

Tgene

CMIP

chr5:32173916

chr16:81641172

ENST00000537098

663_686

100

774.0

Repeat

Note=LRR 1

Tgene

CMIP

chr5:32173916

chr16:81641172

ENST00000537098

687_707

100

774.0

Repeat

Note=LRR 2

Tgene

CMIP

chr5:32173916

chr16:81641172

ENST00000537098

712_732

100

774.0

Repeat

Note=LRR 3

Tgene

CMIP

chr5:32173916

chr16:81641172

ENST00000537098

736_756

100

774.0

Repeat

Note=LRR 4

Tgene

CMIP

chr5:32173916

chr16:81641172

ENST00000539778

663_686

680.0

Repeat

Note=LRR 1

Tgene

CMIP

chr5:32173916

chr16:81641172

ENST00000539778

687_707

680.0

Repeat

Note=LRR 2

Tgene

CMIP

chr5:32173916

chr16:81641172

ENST00000539778

712_732

680.0

Repeat

Note=LRR 3

Tgene

CMIP

chr5:32173916

chr16:81641172

ENST00000539778

736_756

680.0

Repeat

Note=LRR 4

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GOLPH3

chr5:32173916

chr16:81641172

ENST00000265070

190_201

299.0

Region

Beta-hairpin required for oligomerization

Tgene

CMIP

chr5:32173916

chr16:81641172

ENST00000537098

54_163

100

774.0

Domain

Note=PH

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Fusion Gene Sequence for GOLPH3-CMIP

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>33964_33964_1_GOLPH3-CMIP_GOLPH3_chr5_32173916_ENST00000265070_CMIP_chr16_81641172_ENST00000537098_length(transcript)=4526nt_BP=541nt
ACATCCTCCGGTGACGTCAGCCGGGGCCGCCATATTGGAAAGGCGCCGCCGCCGCCTCCGCCTTGGAGCTCGGGGTGTTTCGGGGACTGC
GGCCACAGGCAGGAAGGCGCTCCTCTCCTGCCCCGCCGACGCCCGGCCAGCCCGCTTCGCCCTGACCTGTTTCCTCATGACTGCCCCCGG
CCCTGCTGCCGACGGACGTCGCCCCGGCGTCCGGATTTAACACGGAAACCCGGATCGGAGGCCGCGCGGGGAGGAGGAGGGCGACCCGGT
CGGTCCTGCGACCCTCTCGGCCCGGCTCGGCGCCTCGGCGGGAGCCATGACCTCGCTGACCCAGCGCAGCTCCGGCCTGGTGCAGCGGCG
CACCGAGGCCTCCCGCAACGCCGCCGACAAGGAGCGGGCGGCGGGCGGCGGCGCCGGCAGCAGCGAGGACGACGCGCAGAGCCGCCGCGA
CGAGCAGGACGACGACGACAAGGGCGACTCCAAGGAAACGCGGCTGACCCTGATGGAGGAAGTGCTCCTGCTGGGCCTCAAGGACCGCGA
GCCAACTGGGTACATGGAAAACTCAGTCTCCTACAGCGCAATTGAAGACGTTCAGCTGCTGTCCTGGGAGAATGCCCCGAAGTACTGTTT
ACAGCTCACGATTCCTGGGGGAACTGTCTTACTGCAGGCTGCCAATAGCTACCTGCGAGACCAGTGGTTCCATTCTCTGCAATGGAAGAA
AAAGATTTACAAATATAAGAAAGTGCTGAGTAACCCAAGCCGCTGGGAAGTTGTCTTGAAAGAGATCCGGACCCTGGTGGACATGGCCCT
GACATCCCCCCTGCAGGATGACTCCATCAACCAGGCCCCACTGGAAATCGTCTCGAAACTGCTCTCAGAGAACACAAACTTGACCACCCA
GGAGCATGAAAACATCATTGTGGCAATCGCTCCTTTGCTGGAAAACAACCACCCACCACCAGATCTCTGTGAATTCTTTTGCAAGCACTG
CAGAGAGCGGCCCCGGTCCATGGTGGTCATCGAGGTGTTCACCCCCGTGGTGCAGCGAATCCTCAAGCATAACATGGACTTTGGGAAGTG
CCCGCGACTGAGGCTGTTTACTCAGGAGTACATCCTTGCCTTGAACGAGCTCAACGCGGGGATGGAAGTGGTGAAGAAGTTCATTCAGAG
CATGCACGGCCCCACAGGGCACTGCCCCCACCCCCGGGTCCTGCCCAACCTGGTGGCCGTGTGCCTGGCTGCCATCTACTCCTGCTATGA
AGAGTTCATCAACAGCCGCGACAATTCCCCAAGCCTGAAGGAAATCCGGAACGGCTGCCAGCAGCCGTGCGACCGGAAGCCCACTTTACC
TCTGCGCCTTCTGCACCCCAGCCCGGACCTGGTGTCTCAGGAAGCCACGCTGTCTGAGGCCCGGCTCAAGTCGGTGGTCGTGGCCTCCAG
TGAGATCCACGTGGAGGTGGAACGCACCAGCACTGCCAAGCCGGCGCTGACGGCCAGCGCAGGCAACGACAGCGAGCCCAACCTCATCGA
CTGCCTCATGGTCAGCCCCGCCTGCAGCACCATGAGCATCGAGCTGGGCCCCCAGGCCGACCGCACGCTCGGCTGCTACGTGGAAATCCT
CAAGCTGCTGTCAGACTATGATGACTGGAGACCGTCTCTGGCCAGTTTGCTTCAACCCATTCCATTCCCCAAAGAAGCTCTCGCACATGA
GAAGTTCACCAAGGAACTGAAGTACGTGATTCAGAGGTTCGCCGAAGACCCCAGGCAAGAGGTCCACTCATGCCTGCTGAGCGTGCGGGC
CGGCAAAGATGGCTGGTTCCAGCTCTACAGCCCCGGAGGGGTGGCCTGCGACGATGACGGGGAGCTGTTCGCCAGCATGGTGCACATCCT
CATGGGCTCCTGTTACAAGACCAAAAAATTCCTGCTCTCCCTGGCAGAAAACAAGCTGGGTCCCTGCATGCTCCTGGCACTGAGGGGGAA
CCAGACCATGGTGGAGATCCTGTGCTTGATGCTGGAATACAACATCATCGACAACAACGACACCCAACTGCAGATCATCTCAACCCTGGA
GAGCACAGACGTGGGGAAGCGCATGTACGAGCAGCTGTGTGACCGGCAGCGGGAGCTGAAGGAGCTGCAAAGGAAAGGCGGGCCCACCAG
GCTAACACTGCCCTCCAAGTCCACAGACGCTGACTTGGCTCGTTTGCTGAGCTCCGGCTCCTTCGGAAACCTGGAGAACCTCAGTTTGGC
CTTCACCAATGTAACCAGTGCCTGCGCCGAGCACCTCATCAAACTGCCTTCGCTCAAGCAGCTGAACCTGTGGTCCACTCAGTTTGGAGA
CGCTGGCCTTCGGCTCCTGTCGGAACACCTCACCATGCTCCAGGTGCTGAACCTGTGCGAGACCCCGGTCACAGACGCTGGCCTGCTGGC
CCTGAGCTCCATGAAGAGTCTCTGCAGTTTAAACATGAACAGCACCAAGCTCTCAGCTGACACCTACGAAGATCTGAAGGCCAAGCTTCC
CAATTTGAAGGAAGTGGACGTCCGCTACACCGAAGCCTGGTGAAGCTCCCAGCTCAAGGCAGGAAGACGTTTGCAACCGCGACAAAATAA
CTCTTGACTAACAGCCGCAGAGCAGCCGGTCCTGGGGTCCCACCCTGGTGCCCTGGCTGTGAGATAGATGGGGAGTCTTTCTGGGGGCGG
AGGGGGGAGGGGGTGGGGAGGGGGCCCACAAGCACGCCCAGCCCCCGCCGAATTCTTTTAGCTTCGTAATTGGAACCTTTGACCTGATCT
AAAGTGGACTTTGTAGCAACAAGAGGAGCATCAGCGGGTCGGGGAGGGGTTTGGGGGTGGGCTGGGGGGTGGGGGACCCTTTGTGGATTT
TCTTTGCCTTTGTGTTTGATGCCGTCGTGTGGGAAAAGTCAACTCCGATGCCACCATTGCGGGCCGGACGAAGGATGCTTTCTTCCTAGA
GGCTCCGAGCTGAGCTGCGAACTCGCCCCCCGCCCTTGGGACAAGAAGACCCAGTCACATCACTGCACCCGTCCTGTGTCCTCACCATTG
CTATGCAAAGTGATTCTTGTTGTACATAAGATTTAAATAATGCACCTATTTAAGACATGTTGACAAATTGCGGGTCTGGGACCCGCCTCT
TATTTATGAAGTCTTTGACCGTCCCCCCCGCCCGACCCCACCGCCCTCCCGCCCCCACCTGGCGTGTAGTACTGTATAAACCAGTCAGCT
GTCGGGTTAGTGGTAGTATTATTGTTATTTTTTTAAAGGAAACAAACAGACAACAAAAAGAAGAAAAAAAAAAAGAACCTCCTTGGAAAA
ATTAATTGCTTTTTCGTAATGGATTCTCTATGCTAATGCTCTCTCGTCTGTCTGTCTGTCTGCCCACTCCCCCACCCACCACTGTGCGTT
TCTGATTTCCAAATGTCTCCAACTCCCTCACGAGGTGGGGCTCAGGCTGGAGGAGGAGGGATTAAGATCCCCTTGCTCCACTAAGGCCCA
AGCTCTTTCTCTCGGCACCTTTTAGACTTGAATGGGAGGCTGCTAACCCGCCCTCTCCAGTCCACCCCGGTAAAAGAGCTGTTCCCCACC
CCCAGGGAGCTCCTGTCCCTGTCAGCCTTTGCTGTCCCCTGTCCCCAACGGAGACTCTGTCACCCCTGGGCTCCCCCTGCCATCGTGTGC
TTCACGTGGCCCCATGCATGCCCGCCTCTCTGCATGGTCTCTTGGGAAAAGAGAGATGTGTCGCCTCCGCCAGTCCGACTGCCCTCCCCA
CCCCACCCCCGCCACCCCCCACATGTGACCACTGCAACGAAGACACTCCTTCTGTCCCCACCTGCTCCGAAGACAAACCAACCTCCGTTT
CTTTTATAAACAGTCGGCTTTTTCTTAATAAGCCCTCACTGTACAGAACAGCCCGTTGATGGTTTATTTGGGGTCCCCCTCTCCCCCCAG
CCCTTTTTTCTGTTGGTTTAGCACAAATACTTCCCTCCTCCGGCACCTCCAAACCTACCCCACAGTCAGTGTACTTGTTTTATATATATT
TAATCTTATTCAATGGAAACCATGCTTTTGTCGTTTTATACTTTGCTAGGTAGACTTTATTACCCCCCCACTATGCCCTCATTTTTTTAA
AAAAGGAAAAAAAAAAGAAACTGGGTTCCAGTCTTAATTCATTTTCCGTGCCAGGTTTTATTTCGTGTGTGTGTGAGTGTGTTCTGTTTT
GTGTTTTGTTTTTTGTTGTTGTTTTTAGTTGTTTGGTTTTCTTTTCTTTCCCCCCTCCGGTCCCATACTTCACAGCACTCTGGTGCGGGA
AGAAGCAGAAGCAAAAAAAATAAAAATAAAAAAATAAATAAAAATAAAAAAAATAAAAAAGGAAAAAAAAAAAAGAAGAAACAAGACATG
CCACCTTTCCCCTCGCACTGTTGCTTTTCCTGATGGTTAATACTACTGTCACGTAGCTGTGTACAAAGAGATGTGAAATACTTTCAGGCA

>33964_33964_1_GOLPH3-CMIP_GOLPH3_chr5_32173916_ENST00000265070_CMIP_chr16_81641172_ENST00000537098_length(amino acids)=748AA_BP=67
MTSLTQRSSGLVQRRTEASRNAADKERAAGGGAGSSEDDAQSRRDEQDDDDKGDSKETRLTLMEEVLLLGLKDREPTGYMENSVSYSAIE
DVQLLSWENAPKYCLQLTIPGGTVLLQAANSYLRDQWFHSLQWKKKIYKYKKVLSNPSRWEVVLKEIRTLVDMALTSPLQDDSINQAPLE
IVSKLLSENTNLTTQEHENIIVAIAPLLENNHPPPDLCEFFCKHCRERPRSMVVIEVFTPVVQRILKHNMDFGKCPRLRLFTQEYILALN
ELNAGMEVVKKFIQSMHGPTGHCPHPRVLPNLVAVCLAAIYSCYEEFINSRDNSPSLKEIRNGCQQPCDRKPTLPLRLLHPSPDLVSQEA
TLSEARLKSVVVASSEIHVEVERTSTAKPALTASAGNDSEPNLIDCLMVSPACSTMSIELGPQADRTLGCYVEILKLLSDYDDWRPSLAS
LLQPIPFPKEALAHEKFTKELKYVIQRFAEDPRQEVHSCLLSVRAGKDGWFQLYSPGGVACDDDGELFASMVHILMGSCYKTKKFLLSLA
ENKLGPCMLLALRGNQTMVEILCLMLEYNIIDNNDTQLQIISTLESTDVGKRMYEQLCDRQRELKELQRKGGPTRLTLPSKSTDADLARL
LSSGSFGNLENLSLAFTNVTSACAEHLIKLPSLKQLNLWSTQFGDAGLRLLSEHLTMLQVLNLCETPVTDAGLLALSSMKSLCSLNMNST

--------------------------------------------------------------
>33964_33964_2_GOLPH3-CMIP_GOLPH3_chr5_32173916_ENST00000265070_CMIP_chr16_81641172_ENST00000539778_length(transcript)=4332nt_BP=541nt
ACATCCTCCGGTGACGTCAGCCGGGGCCGCCATATTGGAAAGGCGCCGCCGCCGCCTCCGCCTTGGAGCTCGGGGTGTTTCGGGGACTGC
GGCCACAGGCAGGAAGGCGCTCCTCTCCTGCCCCGCCGACGCCCGGCCAGCCCGCTTCGCCCTGACCTGTTTCCTCATGACTGCCCCCGG
CCCTGCTGCCGACGGACGTCGCCCCGGCGTCCGGATTTAACACGGAAACCCGGATCGGAGGCCGCGCGGGGAGGAGGAGGGCGACCCGGT
CGGTCCTGCGACCCTCTCGGCCCGGCTCGGCGCCTCGGCGGGAGCCATGACCTCGCTGACCCAGCGCAGCTCCGGCCTGGTGCAGCGGCG
CACCGAGGCCTCCCGCAACGCCGCCGACAAGGAGCGGGCGGCGGGCGGCGGCGCCGGCAGCAGCGAGGACGACGCGCAGAGCCGCCGCGA
CGAGCAGGACGACGACGACAAGGGCGACTCCAAGGAAACGCGGCTGACCCTGATGGAGGAAGTGCTCCTGCTGGGCCTCAAGGACCGCGA
GCCAACTGGGTACATGGAAAACTCAGTCTCCTACAGCGCAATTGAAGACGTTCAGCTGCTGTCCTGGGAGAATGCCCCGAAGTACTGTTT
ACAGCTCACGATTCCTGGGGGAACTGTCTTACTGCAGGCTGCCAATAGCTACCTGCGAGACCAGTGGTTCCATTCTCTGCAATGGAAGAA
AAAGATTTACAAATATAAGAAAGTGCTGAGTAACCCAAGCCGCTGGGAAGTTGTCTTGAAAGAGATCCGGACCCTGGTGGACATGGCCCT
GACATCCCCCCTGCAGGATGACTCCATCAACCAGGCCCCACTGGAAATCGTCTCGAAACTGCTCTCAGAGAACACAAACTTGACCACCCA
GGAGCATGAAAACATCATTGTGGCAATCGCTCCTTTGCTGGAAAACAACCACCCACCACCAGATCTCTGTGAATTCTTTTGCAAGCACTG
CAGAGAGCGGCCCCGGTCCATGGTGGTCATCGAGGTGTTCACCCCCGTGGTGCAGCGAATCCTCAAGCATAACATGGACTTTGGGAAGTG
CCCGCGACTGAGGCTGTTTACTCAGGAGTACATCCTTGCCTTGAACGAGCTCAACGCGGGGATGGAAGTGGTGAAGAAGTTCATTCAGAG
CATGCACGGCCCCACAGGGCACTGCCCCCACCCCCGGGTCCTGCCCAACCTGGTGGCCGTGTGCCTGGCTGCCATCTACTCCTGCTATGA
AGAGTTCATCAACAGCCGCGACAATTCCCCAAGCCTGAAGGAAATCCGGAACGGCTGCCAGCAGCCGTGCGACCGGAAGCCCACTTTACC
TCTGCGCCTTCTGCACCCCAGCCCGGACCTGGTGTCTCAGGAAGCCACGCTGTCTGAGGCCCGGCTCAAGTCGGTGGTCGTGGCCTCCAG
TGAGATCCACGTGGAGGTGGAACGCACCAGCACTGCCAAGCCGGCGCTGACGGCCAGCGCAGGCAACGACAGCGAGCCCAACCTCATCGA
CTGCCTCATGGTCAGCCCCGCCTGCAGCACCATGAGCATCGAGCTGGGCCCCCAGGCCGACCGCACGCTCGGCTGCTACGTGGAAATCCT
CAAGCTGCTGTCAGACTATGATGACTGGAGACCGTCTCTGGCCAGTTTGCTTCAACCCATTCCATTCCCCAAAGAAGCTCTCGCACATGA
GAAGTTCACCAAGGAACTGAAGTACGTGATTCAGAGGTTCGCCGAAGACCCCAGGCAAGAGGTCCACTCATGCCTGCTGAGCGTGCGGGC
CGGCAAAGATGGCTGGTTCCAGCTCTACAGCCCCGGAGGGGTGGCCTGCGACGATGACGGGGAGCTGTTCGCCAGCATGGTGCACATCCT
CATGGGCTCCTGTTACAAGACCAAAAAATTCCTGCTCTCCCTGGCAGAAAACAAGCTGGGTCCCTGCATGCTCCTGGCACTGAGGGGGAA
CCAGACCATGGTGGAGATCCTGTGCTTGATGCTGGAATACAACATCATCGACAACAACGACACCCAACTGCAGATCATCTCAACCCTGGA
GAGCACAGACGTGGGGAAGCGCATGTACGAGCAGCTGTGTGACCGGCAGCGGGAGCTGAAGGAGCTGCAAAGGAAAGGCGGGCCCACCAG
GCTAACACTGCCCTCCAAGTCCACAGACGCTGACTTGGCTCGTTTGCTGAGCTCCGGCTCCTTCGGAAACCTGGAGAACCTCAGTTTGGC
CTTCACCAATGTAACCAGTGCCTGCGCCGAGCACCTCATCAAACTGCCTTCGCTCAAGCAGCTGAACCTGTGGTCCACTCAGTTTGGAGA
CGCTGGCCTTCGGCTCCTGTCGGAACACCTCACCATGCTCCAGGTGCTGAACCTGTGCGAGACCCCGGTCACAGACGCTGGCCTGCTGGC
CCTGAGCTCCATGAAGAGTCTCTGCAGTTTAAACATGAACAGCACCAAGCTCTCAGCTGACACCTACGAAGATCTGAAGGCCAAGCTTCC
CAATTTGAAGGAAGTGGACGTCCGCTACACCGAAGCCTGGTGAAGCTCCCAGCTCAAGGCAGGAAGACGTTTGCAACCGCGACAAAATAA
CTCTTGACTAACAGCCGCAGAGCAGCCGGTCCTGGGGTCCCACCCTGGTGCCCTGGCTGTGAGATAGATGGGGAGTCTTTCTGGGGGCGG
AGGGGGGAGGGGGTGGGGAGGGGGCCCACAAGCACGCCCAGCCCCCGCCGAATTCTTTTAGCTTCGTAATTGGAACCTTTGACCTGATCT
AAAGTGGACTTTGTAGCAACAAGAGGAGCATCAGCGGGTCGGGGAGGGGTTTGGGGGTGGGCTGGGGGGTGGGGGACCCTTTGTGGATTT
TCTTTGCCTTTGTGTTTGATGCCGTCGTGTGGGAAAAGTCAACTCCGATGCCACCATTGCGGGCCGGACGAAGGATGCTTTCTTCCTAGA
GGCTCCGAGCTGAGCTGCGAACTCGCCCCCCGCCCTTGGGACAAGAAGACCCAGTCACATCACTGCACCCGTCCTGTGTCCTCACCATTG
CTATGCAAAGTGATTCTTGTTGTACATAAGATTTAAATAATGCACCTATTTAAGACATGTTGACAAATTGCGGGTCTGGGACCCGCCTCT
TATTTATGAAGTCTTTGACCGTCCCCCCCGCCCGACCCCACCGCCCTCCCGCCCCCACCTGGCGTGTAGTACTGTATAAACCAGTCAGCT
GTCGGGTTAGTGGTAGTATTATTGTTATTTTTTTAAAGGAAACAAACAGACAACAAAAAGAAGAAAAAAAAAAAGAACCTCCTTGGAAAA
ATTAATTGCTTTTTCGTAATGGATTCTCTATGCTAATGCTCTCTCGTCTGTCTGTCTGTCTGCCCACTCCCCCACCCACCACTGTGCGTT
TCTGATTTCCAAATGTCTCCAACTCCCTCACGAGGTGGGGCTCAGGCTGGAGGAGGAGGGATTAAGATCCCCTTGCTCCACTAAGGCCCA
AGCTCTTTCTCTCGGCACCTTTTAGACTTGAATGGGAGGCTGCTAACCCGCCCTCTCCAGTCCACCCCGGTAAAAGAGCTGTTCCCCACC
CCCAGGGAGCTCCTGTCCCTGTCAGCCTTTGCTGTCCCCTGTCCCCAACGGAGACTCTGTCACCCCTGGGCTCCCCCTGCCATCGTGTGC
TTCACGTGGCCCCATGCATGCCCGCCTCTCTGCATGGTCTCTTGGGAAAAGAGAGATGTGTCGCCTCCGCCAGTCCGACTGCCCTCCCCA
CCCCACCCCCGCCACCCCCCACATGTGACCACTGCAACGAAGACACTCCTTCTGTCCCCACCTGCTCCGAAGACAAACCAACCTCCGTTT
CTTTTATAAACAGTCGGCTTTTTCTTAATAAGCCCTCACTGTACAGAACAGCCCGTTGATGGTTTATTTGGGGTCCCCCTCTCCCCCCAG
CCCTTTTTTCTGTTGGTTTAGCACAAATACTTCCCTCCTCCGGCACCTCCAAACCTACCCCACAGTCAGTGTACTTGTTTTATATATATT
TAATCTTATTCAATGGAAACCATGCTTTTGTCGTTTTATACTTTGCTAGGTAGACTTTATTACCCCCCCACTATGCCCTCATTTTTTTAA
AAAAGGAAAAAAAAAAGAAACTGGGTTCCAGTCTTAATTCATTTTCCGTGCCAGGTTTTATTTCGTGTGTGTGTGAGTGTGTTCTGTTTT
GTGTTTTGTTTTTTGTTGTTGTTTTTAGTTGTTTGGTTTTCTTTTCTTTCCCCCCTCCGGTCCCATACTTCACAGCACTCTGGTGCGGGA

>33964_33964_2_GOLPH3-CMIP_GOLPH3_chr5_32173916_ENST00000265070_CMIP_chr16_81641172_ENST00000539778_length(amino acids)=748AA_BP=67
MTSLTQRSSGLVQRRTEASRNAADKERAAGGGAGSSEDDAQSRRDEQDDDDKGDSKETRLTLMEEVLLLGLKDREPTGYMENSVSYSAIE
DVQLLSWENAPKYCLQLTIPGGTVLLQAANSYLRDQWFHSLQWKKKIYKYKKVLSNPSRWEVVLKEIRTLVDMALTSPLQDDSINQAPLE
IVSKLLSENTNLTTQEHENIIVAIAPLLENNHPPPDLCEFFCKHCRERPRSMVVIEVFTPVVQRILKHNMDFGKCPRLRLFTQEYILALN
ELNAGMEVVKKFIQSMHGPTGHCPHPRVLPNLVAVCLAAIYSCYEEFINSRDNSPSLKEIRNGCQQPCDRKPTLPLRLLHPSPDLVSQEA
TLSEARLKSVVVASSEIHVEVERTSTAKPALTASAGNDSEPNLIDCLMVSPACSTMSIELGPQADRTLGCYVEILKLLSDYDDWRPSLAS
LLQPIPFPKEALAHEKFTKELKYVIQRFAEDPRQEVHSCLLSVRAGKDGWFQLYSPGGVACDDDGELFASMVHILMGSCYKTKKFLLSLA
ENKLGPCMLLALRGNQTMVEILCLMLEYNIIDNNDTQLQIISTLESTDVGKRMYEQLCDRQRELKELQRKGGPTRLTLPSKSTDADLARL
LSSGSFGNLENLSLAFTNVTSACAEHLIKLPSLKQLNLWSTQFGDAGLRLLSEHLTMLQVLNLCETPVTDAGLLALSSMKSLCSLNMNST

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Top

Fusion Gene PPI Analysis for GOLPH3-CMIP

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GOLPH3-CMIP

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for GOLPH3-CMIP

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source