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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GOLPH3-SLC6A19 (FusionGDB2 ID:33980)

Fusion Gene Summary for GOLPH3-SLC6A19

check button Fusion gene summary
Fusion gene informationFusion gene name: GOLPH3-SLC6A19
Fusion gene ID: 33980
HgeneTgene
Gene symbol

GOLPH3

SLC6A19

Gene ID

64083

340024

Gene namegolgi phosphoprotein 3solute carrier family 6 member 19
SynonymsGOPP1|GPP34|MIDAS|Vps74B0AT1|HND
Cytomap

5p13.3

5p15.33

Type of geneprotein-codingprotein-coding
DescriptionGolgi phosphoprotein 3coat protein GPP34coat-proteingolgi peripheral membrane protein 1, 34 kDagolgi proteingolgi-associated proteinmitochondrial DNA absence factorsodium-dependent neutral amino acid transporter B(0)AT1sodium-dependent amino acid transporter system B0solute carrier family 6 (neurotransmitter transporter), member 19solute carrier family 6 (neutral amino acid transporter), member 19system B(0) neu
Modification date2020032920200313
UniProtAcc

Q9H4A6

.
Ensembl transtripts involved in fusion geneENST00000512668, ENST00000265070, 
ENST00000304460, 
Fusion gene scores* DoF score11 X 10 X 7=7706 X 5 X 6=180
# samples 167
** MAII scorelog2(16/770*10)=-2.2667865406949
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GOLPH3 [Title/Abstract] AND SLC6A19 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGOLPH3(32173916)-SLC6A19(1219018), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGOLPH3

GO:0010821

regulation of mitochondrion organization

16263763


check buttonFusion gene breakpoints across GOLPH3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC6A19 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-5496-01AGOLPH3chr5

32173916

-SLC6A19chr5

1219018

+
ChimerDB4PRADTCGA-EJ-5496GOLPH3chr5

32173915

-SLC6A19chr5

1219017

+
ChimerDB4PRADTCGA-EJ-5496GOLPH3chr5

32173916

-SLC6A19chr5

1219018

+


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Fusion Gene ORF analysis for GOLPH3-SLC6A19

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000512668ENST00000304460GOLPH3chr5

32173916

-SLC6A19chr5

1219018

+
5UTR-3CDSENST00000512668ENST00000304460GOLPH3chr5

32173915

-SLC6A19chr5

1219017

+
In-frameENST00000265070ENST00000304460GOLPH3chr5

32173916

-SLC6A19chr5

1219018

+
In-frameENST00000265070ENST00000304460GOLPH3chr5

32173915

-SLC6A19chr5

1219017

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265070GOLPH3chr532173916-ENST00000304460SLC6A19chr51219018+44865412169655504
ENST00000265070GOLPH3chr532173915-ENST00000304460SLC6A19chr51219017+44865412169655504

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265070ENST00000304460GOLPH3chr532173916-SLC6A19chr51219018+0.000339550.9996605
ENST00000265070ENST00000304460GOLPH3chr532173915-SLC6A19chr51219017+0.000339550.9996605

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Fusion Genomic Features for GOLPH3-SLC6A19


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GOLPH3chr532173915-SLC6A19chr51219017+2.14E-101
GOLPH3chr532173915-SLC6A19chr51219017+2.14E-101
GOLPH3chr532173915-SLC6A19chr51219017+2.14E-101
GOLPH3chr532173915-SLC6A19chr51219017+2.14E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GOLPH3-SLC6A19


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:32173916/chr5:1219018)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GOLPH3

Q9H4A6

.
FUNCTION: Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis. {ECO:0000269|PubMed:16263763, ECO:0000269|PubMed:19553991, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:22745132, ECO:0000269|PubMed:23027862, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:23500462}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGOLPH3chr5:32173915chr5:1219017ENST00000265070-1448_5175299.0Compositional biasNote=Poly-Asp
HgeneGOLPH3chr5:32173916chr5:1219018ENST00000265070-1448_5175299.0Compositional biasNote=Poly-Asp
TgeneSLC6A19chr5:32173915chr5:1219017ENST00000304460712435_456391635.0Topological domainCytoplasmic
TgeneSLC6A19chr5:32173915chr5:1219017ENST00000304460712478_490391635.0Topological domainExtracellular
TgeneSLC6A19chr5:32173915chr5:1219017ENST00000304460712512_531391635.0Topological domainCytoplasmic
TgeneSLC6A19chr5:32173915chr5:1219017ENST00000304460712553_581391635.0Topological domainExtracellular
TgeneSLC6A19chr5:32173915chr5:1219017ENST00000304460712603_634391635.0Topological domainCytoplasmic
TgeneSLC6A19chr5:32173916chr5:1219018ENST00000304460712435_456391635.0Topological domainCytoplasmic
TgeneSLC6A19chr5:32173916chr5:1219018ENST00000304460712478_490391635.0Topological domainExtracellular
TgeneSLC6A19chr5:32173916chr5:1219018ENST00000304460712512_531391635.0Topological domainCytoplasmic
TgeneSLC6A19chr5:32173916chr5:1219018ENST00000304460712553_581391635.0Topological domainExtracellular
TgeneSLC6A19chr5:32173916chr5:1219018ENST00000304460712603_634391635.0Topological domainCytoplasmic
TgeneSLC6A19chr5:32173915chr5:1219017ENST00000304460712414_434391635.0TransmembraneHelical%3B Name%3D8
TgeneSLC6A19chr5:32173915chr5:1219017ENST00000304460712457_477391635.0TransmembraneHelical%3B Name%3D9
TgeneSLC6A19chr5:32173915chr5:1219017ENST00000304460712491_511391635.0TransmembraneHelical%3B Name%3D10
TgeneSLC6A19chr5:32173915chr5:1219017ENST00000304460712532_552391635.0TransmembraneHelical%3B Name%3D11
TgeneSLC6A19chr5:32173915chr5:1219017ENST00000304460712582_602391635.0TransmembraneHelical%3B Name%3D12
TgeneSLC6A19chr5:32173916chr5:1219018ENST00000304460712414_434391635.0TransmembraneHelical%3B Name%3D8
TgeneSLC6A19chr5:32173916chr5:1219018ENST00000304460712457_477391635.0TransmembraneHelical%3B Name%3D9
TgeneSLC6A19chr5:32173916chr5:1219018ENST00000304460712491_511391635.0TransmembraneHelical%3B Name%3D10
TgeneSLC6A19chr5:32173916chr5:1219018ENST00000304460712532_552391635.0TransmembraneHelical%3B Name%3D11
TgeneSLC6A19chr5:32173916chr5:1219018ENST00000304460712582_602391635.0TransmembraneHelical%3B Name%3D12

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGOLPH3chr5:32173915chr5:1219017ENST00000265070-14190_20175299.0RegionBeta-hairpin required for oligomerization
HgeneGOLPH3chr5:32173916chr5:1219018ENST00000265070-14190_20175299.0RegionBeta-hairpin required for oligomerization
TgeneSLC6A19chr5:32173915chr5:1219017ENST00000304460712142_192391635.0Topological domainExtracellular
TgeneSLC6A19chr5:32173915chr5:1219017ENST000003044607121_41391635.0Topological domainCytoplasmic
TgeneSLC6A19chr5:32173915chr5:1219017ENST00000304460712214_221391635.0Topological domainCytoplasmic
TgeneSLC6A19chr5:32173915chr5:1219017ENST00000304460712243_268391635.0Topological domainExtracellular
TgeneSLC6A19chr5:32173915chr5:1219017ENST00000304460712290_304391635.0Topological domainCytoplasmic
TgeneSLC6A19chr5:32173915chr5:1219017ENST00000304460712326_413391635.0Topological domainExtracellular
TgeneSLC6A19chr5:32173915chr5:1219017ENST0000030446071263_67391635.0Topological domainExtracellular
TgeneSLC6A19chr5:32173915chr5:1219017ENST0000030446071289_120391635.0Topological domainCytoplasmic
TgeneSLC6A19chr5:32173916chr5:1219018ENST00000304460712142_192391635.0Topological domainExtracellular
TgeneSLC6A19chr5:32173916chr5:1219018ENST000003044607121_41391635.0Topological domainCytoplasmic
TgeneSLC6A19chr5:32173916chr5:1219018ENST00000304460712214_221391635.0Topological domainCytoplasmic
TgeneSLC6A19chr5:32173916chr5:1219018ENST00000304460712243_268391635.0Topological domainExtracellular
TgeneSLC6A19chr5:32173916chr5:1219018ENST00000304460712290_304391635.0Topological domainCytoplasmic
TgeneSLC6A19chr5:32173916chr5:1219018ENST00000304460712326_413391635.0Topological domainExtracellular
TgeneSLC6A19chr5:32173916chr5:1219018ENST0000030446071263_67391635.0Topological domainExtracellular
TgeneSLC6A19chr5:32173916chr5:1219018ENST0000030446071289_120391635.0Topological domainCytoplasmic
TgeneSLC6A19chr5:32173915chr5:1219017ENST00000304460712121_141391635.0TransmembraneHelical%3B Name%3D3
TgeneSLC6A19chr5:32173915chr5:1219017ENST00000304460712193_213391635.0TransmembraneHelical%3B Name%3D4
TgeneSLC6A19chr5:32173915chr5:1219017ENST00000304460712222_242391635.0TransmembraneHelical%3B Name%3D5
TgeneSLC6A19chr5:32173915chr5:1219017ENST00000304460712269_289391635.0TransmembraneHelical%3B Name%3D6
TgeneSLC6A19chr5:32173915chr5:1219017ENST00000304460712305_325391635.0TransmembraneHelical%3B Name%3D7
TgeneSLC6A19chr5:32173915chr5:1219017ENST0000030446071242_62391635.0TransmembraneHelical%3B Name%3D1
TgeneSLC6A19chr5:32173915chr5:1219017ENST0000030446071268_88391635.0TransmembraneHelical%3B Name%3D2
TgeneSLC6A19chr5:32173916chr5:1219018ENST00000304460712121_141391635.0TransmembraneHelical%3B Name%3D3
TgeneSLC6A19chr5:32173916chr5:1219018ENST00000304460712193_213391635.0TransmembraneHelical%3B Name%3D4
TgeneSLC6A19chr5:32173916chr5:1219018ENST00000304460712222_242391635.0TransmembraneHelical%3B Name%3D5
TgeneSLC6A19chr5:32173916chr5:1219018ENST00000304460712269_289391635.0TransmembraneHelical%3B Name%3D6
TgeneSLC6A19chr5:32173916chr5:1219018ENST00000304460712305_325391635.0TransmembraneHelical%3B Name%3D7
TgeneSLC6A19chr5:32173916chr5:1219018ENST0000030446071242_62391635.0TransmembraneHelical%3B Name%3D1
TgeneSLC6A19chr5:32173916chr5:1219018ENST0000030446071268_88391635.0TransmembraneHelical%3B Name%3D2


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Fusion Gene Sequence for GOLPH3-SLC6A19


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>33980_33980_1_GOLPH3-SLC6A19_GOLPH3_chr5_32173915_ENST00000265070_SLC6A19_chr5_1219017_ENST00000304460_length(transcript)=4486nt_BP=541nt
ACATCCTCCGGTGACGTCAGCCGGGGCCGCCATATTGGAAAGGCGCCGCCGCCGCCTCCGCCTTGGAGCTCGGGGTGTTTCGGGGACTGC
GGCCACAGGCAGGAAGGCGCTCCTCTCCTGCCCCGCCGACGCCCGGCCAGCCCGCTTCGCCCTGACCTGTTTCCTCATGACTGCCCCCGG
CCCTGCTGCCGACGGACGTCGCCCCGGCGTCCGGATTTAACACGGAAACCCGGATCGGAGGCCGCGCGGGGAGGAGGAGGGCGACCCGGT
CGGTCCTGCGACCCTCTCGGCCCGGCTCGGCGCCTCGGCGGGAGCCATGACCTCGCTGACCCAGCGCAGCTCCGGCCTGGTGCAGCGGCG
CACCGAGGCCTCCCGCAACGCCGCCGACAAGGAGCGGGCGGCGGGCGGCGGCGCCGGCAGCAGCGAGGACGACGCGCAGAGCCGCCGCGA
CGAGCAGGACGACGACGACAAGGGCGACTCCAAGGAAACGCGGCTGACCCTGATGGAGGAAGTGCTCCTGCTGGGCCTCAAGGACCGCGA
GGCCGTGGAGGGCACAGGCCTGGCCTTCATCGTCTTCACCGAGGCCATCACCAAGATGCCGTTGTCCCCACTGTGGTCTGTGCTCTTCTT
CATTATGCTCTTCTGCCTGGGGCTGTCATCTATGTTTGGGAACATGGAGGGCGTCGTTGTGCCCCTGCAGGACCTCAGAGTCATCCCCCC
GAAGTGGCCCAAGGAGGTGCTCACAGGCCTCATCTGCCTGGGGACATTCCTCATTGGCTTCATCTTCACGCTGAACTCCGGCCAGTACTG
GCTCTCCCTGCTGGACAGCTATGCCGGCTCCATTCCCCTGCTCATCATCGCCTTCTGCGAGATGTTCTCTGTGGTCTACGTGTACGGTGT
GGACAGGTTCAATAAGGACATCGAGTTCATGATCGGCCACAAGCCCAACATCTTCTGGCAAGTCACGTGGCGCGTGGTCAGCCCCCTGCT
CATGCTGATCATCTTCCTCTTCTTCTTCGTGGTAGAGGTCAGTCAGGAGCTGACCTACAGCATCTGGGACCCTGGCTACGAGGAATTTCC
CAAATCCCAGAAGATCTCCTACCCGAACTGGGTGTATGTGGTGGTGGTGATTGTGGCTGGAGTGCCCTCCCTCACCATCCCTGGCTATGC
CATCTACAAGCTCATCAGGAACCACTGCCAGAAGCCAGGGGACCATCAGGGGCTGGTGAGCACACTGTCCACAGCCTCCATGAACGGGGA
CCTGAAGTACTGAGAAGGCCCATCCCACGGCGTGCCATACACTGGTGTCAGGGAAGGAGGAACCAGCAAGACCTGTGGGGTGGGGGCCGG
GCTGCACCTGCATGTGTGTAAGCGTGAGTGTATGCTCGTGTGTGAGTGTGTGTATTGTACACGCATGTGCCATGTGTGCAGATATGTATC
GTGTGTGCATGTACATGCATGGGCACTGTGTGAGTGTGCACGTGTATGCACACATATACATGTGTGTGGGTGTGTGTATTGTATGTGCAT
GTGCCATGTGTGCAGATGTGTCATGTTGTGTGTGTGCATGTACATGTATGGACATTGTGTGAGTGTGCAAGTGTGCATGCATATACATGT
GTGCGATATTTGCTGCCCGTGTGTGTGCATGTATATATAGACATACATGCCTATGTTGTGTGTGGTGTGCATATGTGTGAACACACACGT
GTATACATGCATGCACATGTGCTCGTACAATGGGTGTCCACATGCACGTGTATATGTATATCTGTGAGTGTATATACATGCATGCAATTG
TGTGTATGTGTGTTCTGTGTGTGCGTTTGCAAGTATATATGCACATGTGTATATGTACATGTATGCCTGTGTGACGTGTGTATATGTGAG
CATGTGTACGTGTGTGTATACGTGTGTTGTGTATATGTGTGTGTCTGTACCTGTTTGTGTATATGTGTGTGATGTGTGCTCGTGTGTGTG
CATATTCAGGCAGGTGTGCATTTGTGCATGCCAGTGTGTATGTATGTGCGCATATGGACACGCATGGACACGCATATGGACACATATGGA
CACACATATGGACACGTGTGGATATGTGTGCGTACACGTCGCTGGGACACATGCCTGCCACTCGGGGCCCAGCTGCCCTCTGTGTTTGTC
CTTGCCACAGTCACGGGGTGCATGTGCAGAGGGGAGCAGACCACTGGGGACGTGCTGTGCCCTGCACGTGCCCGGGGGAAGCGGAAGCTG
CAGCTGGGGTGGGGGCAGCACCTCTATGCTTCATCTCTGTGGGTGGCAGGAGACAAAAGCACAGGGTACTATCTTGGCTCCTGGGAGCGA
CTCTTGCTACCCACCCCCACCCATCCCCTTCCCCTTGGTGTTGACCTTTGACCTGGGGGTTCCCAGAGCCCTGTAGCCCTCGACCCGGAG
CAGCCTCTCGGAAGCCGGAGTGGGCAGTTGCTGGCGATTCTGAGAAAACTTGGCCGCATCCACCGGGGCCCTGCCTCCAGTCGGCCGCTG
CCGAGTCTCTGCGTTCTGGCCGCTTCCCGGCTTAATGAATGCCAGCCATTTAATCATTGCTCCTGCCACCACAAATAGATGAGCAGTTAA
ATAAAACTCAACTTGGCATAATTCAAGGCAAATACCACTCTGTGCATTTTCTTAAGAGGACATGAGCTGTGTGAATTTTTAGCCAGCCTT
TGGAAAAGATGGGTTACAGGGTAACTCAACCCTGGCTGCCATCCTTGGGCACTGTGTGTGTCCAGGGCACCTTGGAGGACCGTGCAGCCC
CCAGAAGCTTCCAGCTCCCGCACCACTCAGTGAAGCCCAGCCTGGCGCCTGCCCTGCCCCCGTCACGGGATGGGCCCCCATTGGGGTTCA
ACATTCCATCGCAGCCAAAGGCAGTCGGCACTTGGGACATCTGCTTCCACGGACAGGTCACCTCCGCTTTGCACGGAAGAATCTGGATGC
TTACATTAAACTGGTGTTCTGAGAGTTCCTACGGACAGGTCACCTCCGCTTTGCATGGAAGAATCTGGATGCTTACATTAAACTGGTGTT
CTGAGAGTTCCTACGGACAGGTCACCTCTGCTTTCCATAGAAGAATCTGGACGCTTACATTAAACTGATGTTCTGAGAATTCCTACAGGC
AGGACTGAAAGCCTGGTGTGTGCCAGTATGATGTTCCACCCACAGAAACCTGGTCACAATCGTCCCTTCCAGCACCCCATCCAGCAGTGA
CTGCACACACTGAGTCCCCTACCAGCCCCTTTCACCCTGCTGACTGTCACTGGGCCCTGGGATGCGCAAGACTCCACAGCAGCAGAGGTG
GGGGGACATATCACAGCCTCTGCCCCCGGCTGTGATGCCACCGAGGGGCTCGCCTGCTGATGGCTTCAACAGGGTCTCACCTCATCTTTT
CCTGCTCTTTGGCCCTGGATCGAGAAAATTTCCATCAGTGCCCCATTAATATGCTGCCCTGTGGCATCTGCCCAGGAGGCCCTGCCAGGC
GTGCACAGGTGTGCATTGGTGTACCCTGGCATGCACAGGTGTGCACTGATGTGCCCTGGCATCCATTGGTGTACCCTGGTGTGCCTGCCA
TAGGACCCTGGGCGGGAGCTCCCATCTCATCTACATCTCCTGATTCATGCGTTGTTTCATAGGTTTCAATGTCTCTGTAAATGTGGTAGA
AATGCAGGCTTTATGGGCATAAAGTGTACATTTCTAAATAAATCCCTTCTATTGAGTATGCTCACCCTAGAAGTTACTGTTGTCCAGACG
TAGAGGGATGAGTGAGCCAGTGACCTCAGACGGGATGGTGGGGACGGCAGGTCCAGCTCCTGCCTCCTCCTGGGGGGTCTGGCTTTGGGG
GCTTGCTCCGAAGAGGCCATGGCCCAGGCCTGTGGCCTCACAATGGGGACCAACCAGCTCTTCTCATCTTCTTCCCTCACACTTCCTCTC
ACTCAAATAAGAACCTTCCAAAAATGTGTCCACCTGGGCCCCTGCCCTGGGACTCATGGATTTGGAGTTGTGGCCACACGGTTGAGGGGT
GCAGTGTCCAGTGGAATGGGGCAATTGCGGGCCTGGGGGCCCTTGGCCTGTCCGTGGCGGGAGCATCTGCAAGGAGGAGCCCCAGAGTCC
AGGGAGCACTGTGGGGAGCTCCTTAGAGCTGAACTCACCCGGCGTCAACTCATCAACCCTCCACCCATGGACAGGGGTGCCCCCAGCACA
GGAGAGGACTCAGCCCTCTGCCCCCACGCACGGTGGGTGCCTGTCACCCTGTCCTGCCCAGCGGCCCGAGGGCAGCAGTGGGTGTGAGGG
CAGCCCCCGGCCTCCCAAGAGCAGCTGAGAGGATCCCTGCGGGAATCCGGGCTTCGGGTGCATGCGATCTGATCTGAGTTGTTTCTGACA

>33980_33980_1_GOLPH3-SLC6A19_GOLPH3_chr5_32173915_ENST00000265070_SLC6A19_chr5_1219017_ENST00000304460_length(amino acids)=504AA_BP=189
MWQGQTQRAAGPRVAGMCPSDVYAHISTRVHMCVHMCPYACPCVSICAHTYTLACTNAHLPEYAHTRAHITHIYTNRYRHTHIHNTRIHT
RTHAHIYTRHTGIHVHIHMCIYTCKRTHRTHIHTIACMYIHSQIYIYTCMWTPIVRAHVHACIHVCVHTYAHHTQHRHVCLYIHAHTRAA
NIAHMYMHAHLHTHTMSIHVHAHTQHDTSAHMAHAHTIHTPTHMYMCAYTCTLTQCPCMYMHTRYISAHMAHACTIHTLTHEHTLTLTHM
QVQPGPHPTGLAGSSFPDTSVWHAVGWAFSVLQVPVHGGCGQCAHQPLMVPWLLAVVPDELVDGIARDGEGGHSSHNHHHHIHPVRVGDL
LGFGKFLVARVPDAVGQLLTDLYHEEEEEDDQHEQGADHAPRDLPEDVGLVADHELDVLIEPVHTVHVDHREHLAEGDDEQGNGAGIAVQ

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>33980_33980_2_GOLPH3-SLC6A19_GOLPH3_chr5_32173916_ENST00000265070_SLC6A19_chr5_1219018_ENST00000304460_length(transcript)=4486nt_BP=541nt
ACATCCTCCGGTGACGTCAGCCGGGGCCGCCATATTGGAAAGGCGCCGCCGCCGCCTCCGCCTTGGAGCTCGGGGTGTTTCGGGGACTGC
GGCCACAGGCAGGAAGGCGCTCCTCTCCTGCCCCGCCGACGCCCGGCCAGCCCGCTTCGCCCTGACCTGTTTCCTCATGACTGCCCCCGG
CCCTGCTGCCGACGGACGTCGCCCCGGCGTCCGGATTTAACACGGAAACCCGGATCGGAGGCCGCGCGGGGAGGAGGAGGGCGACCCGGT
CGGTCCTGCGACCCTCTCGGCCCGGCTCGGCGCCTCGGCGGGAGCCATGACCTCGCTGACCCAGCGCAGCTCCGGCCTGGTGCAGCGGCG
CACCGAGGCCTCCCGCAACGCCGCCGACAAGGAGCGGGCGGCGGGCGGCGGCGCCGGCAGCAGCGAGGACGACGCGCAGAGCCGCCGCGA
CGAGCAGGACGACGACGACAAGGGCGACTCCAAGGAAACGCGGCTGACCCTGATGGAGGAAGTGCTCCTGCTGGGCCTCAAGGACCGCGA
GGCCGTGGAGGGCACAGGCCTGGCCTTCATCGTCTTCACCGAGGCCATCACCAAGATGCCGTTGTCCCCACTGTGGTCTGTGCTCTTCTT
CATTATGCTCTTCTGCCTGGGGCTGTCATCTATGTTTGGGAACATGGAGGGCGTCGTTGTGCCCCTGCAGGACCTCAGAGTCATCCCCCC
GAAGTGGCCCAAGGAGGTGCTCACAGGCCTCATCTGCCTGGGGACATTCCTCATTGGCTTCATCTTCACGCTGAACTCCGGCCAGTACTG
GCTCTCCCTGCTGGACAGCTATGCCGGCTCCATTCCCCTGCTCATCATCGCCTTCTGCGAGATGTTCTCTGTGGTCTACGTGTACGGTGT
GGACAGGTTCAATAAGGACATCGAGTTCATGATCGGCCACAAGCCCAACATCTTCTGGCAAGTCACGTGGCGCGTGGTCAGCCCCCTGCT
CATGCTGATCATCTTCCTCTTCTTCTTCGTGGTAGAGGTCAGTCAGGAGCTGACCTACAGCATCTGGGACCCTGGCTACGAGGAATTTCC
CAAATCCCAGAAGATCTCCTACCCGAACTGGGTGTATGTGGTGGTGGTGATTGTGGCTGGAGTGCCCTCCCTCACCATCCCTGGCTATGC
CATCTACAAGCTCATCAGGAACCACTGCCAGAAGCCAGGGGACCATCAGGGGCTGGTGAGCACACTGTCCACAGCCTCCATGAACGGGGA
CCTGAAGTACTGAGAAGGCCCATCCCACGGCGTGCCATACACTGGTGTCAGGGAAGGAGGAACCAGCAAGACCTGTGGGGTGGGGGCCGG
GCTGCACCTGCATGTGTGTAAGCGTGAGTGTATGCTCGTGTGTGAGTGTGTGTATTGTACACGCATGTGCCATGTGTGCAGATATGTATC
GTGTGTGCATGTACATGCATGGGCACTGTGTGAGTGTGCACGTGTATGCACACATATACATGTGTGTGGGTGTGTGTATTGTATGTGCAT
GTGCCATGTGTGCAGATGTGTCATGTTGTGTGTGTGCATGTACATGTATGGACATTGTGTGAGTGTGCAAGTGTGCATGCATATACATGT
GTGCGATATTTGCTGCCCGTGTGTGTGCATGTATATATAGACATACATGCCTATGTTGTGTGTGGTGTGCATATGTGTGAACACACACGT
GTATACATGCATGCACATGTGCTCGTACAATGGGTGTCCACATGCACGTGTATATGTATATCTGTGAGTGTATATACATGCATGCAATTG
TGTGTATGTGTGTTCTGTGTGTGCGTTTGCAAGTATATATGCACATGTGTATATGTACATGTATGCCTGTGTGACGTGTGTATATGTGAG
CATGTGTACGTGTGTGTATACGTGTGTTGTGTATATGTGTGTGTCTGTACCTGTTTGTGTATATGTGTGTGATGTGTGCTCGTGTGTGTG
CATATTCAGGCAGGTGTGCATTTGTGCATGCCAGTGTGTATGTATGTGCGCATATGGACACGCATGGACACGCATATGGACACATATGGA
CACACATATGGACACGTGTGGATATGTGTGCGTACACGTCGCTGGGACACATGCCTGCCACTCGGGGCCCAGCTGCCCTCTGTGTTTGTC
CTTGCCACAGTCACGGGGTGCATGTGCAGAGGGGAGCAGACCACTGGGGACGTGCTGTGCCCTGCACGTGCCCGGGGGAAGCGGAAGCTG
CAGCTGGGGTGGGGGCAGCACCTCTATGCTTCATCTCTGTGGGTGGCAGGAGACAAAAGCACAGGGTACTATCTTGGCTCCTGGGAGCGA
CTCTTGCTACCCACCCCCACCCATCCCCTTCCCCTTGGTGTTGACCTTTGACCTGGGGGTTCCCAGAGCCCTGTAGCCCTCGACCCGGAG
CAGCCTCTCGGAAGCCGGAGTGGGCAGTTGCTGGCGATTCTGAGAAAACTTGGCCGCATCCACCGGGGCCCTGCCTCCAGTCGGCCGCTG
CCGAGTCTCTGCGTTCTGGCCGCTTCCCGGCTTAATGAATGCCAGCCATTTAATCATTGCTCCTGCCACCACAAATAGATGAGCAGTTAA
ATAAAACTCAACTTGGCATAATTCAAGGCAAATACCACTCTGTGCATTTTCTTAAGAGGACATGAGCTGTGTGAATTTTTAGCCAGCCTT
TGGAAAAGATGGGTTACAGGGTAACTCAACCCTGGCTGCCATCCTTGGGCACTGTGTGTGTCCAGGGCACCTTGGAGGACCGTGCAGCCC
CCAGAAGCTTCCAGCTCCCGCACCACTCAGTGAAGCCCAGCCTGGCGCCTGCCCTGCCCCCGTCACGGGATGGGCCCCCATTGGGGTTCA
ACATTCCATCGCAGCCAAAGGCAGTCGGCACTTGGGACATCTGCTTCCACGGACAGGTCACCTCCGCTTTGCACGGAAGAATCTGGATGC
TTACATTAAACTGGTGTTCTGAGAGTTCCTACGGACAGGTCACCTCCGCTTTGCATGGAAGAATCTGGATGCTTACATTAAACTGGTGTT
CTGAGAGTTCCTACGGACAGGTCACCTCTGCTTTCCATAGAAGAATCTGGACGCTTACATTAAACTGATGTTCTGAGAATTCCTACAGGC
AGGACTGAAAGCCTGGTGTGTGCCAGTATGATGTTCCACCCACAGAAACCTGGTCACAATCGTCCCTTCCAGCACCCCATCCAGCAGTGA
CTGCACACACTGAGTCCCCTACCAGCCCCTTTCACCCTGCTGACTGTCACTGGGCCCTGGGATGCGCAAGACTCCACAGCAGCAGAGGTG
GGGGGACATATCACAGCCTCTGCCCCCGGCTGTGATGCCACCGAGGGGCTCGCCTGCTGATGGCTTCAACAGGGTCTCACCTCATCTTTT
CCTGCTCTTTGGCCCTGGATCGAGAAAATTTCCATCAGTGCCCCATTAATATGCTGCCCTGTGGCATCTGCCCAGGAGGCCCTGCCAGGC
GTGCACAGGTGTGCATTGGTGTACCCTGGCATGCACAGGTGTGCACTGATGTGCCCTGGCATCCATTGGTGTACCCTGGTGTGCCTGCCA
TAGGACCCTGGGCGGGAGCTCCCATCTCATCTACATCTCCTGATTCATGCGTTGTTTCATAGGTTTCAATGTCTCTGTAAATGTGGTAGA
AATGCAGGCTTTATGGGCATAAAGTGTACATTTCTAAATAAATCCCTTCTATTGAGTATGCTCACCCTAGAAGTTACTGTTGTCCAGACG
TAGAGGGATGAGTGAGCCAGTGACCTCAGACGGGATGGTGGGGACGGCAGGTCCAGCTCCTGCCTCCTCCTGGGGGGTCTGGCTTTGGGG
GCTTGCTCCGAAGAGGCCATGGCCCAGGCCTGTGGCCTCACAATGGGGACCAACCAGCTCTTCTCATCTTCTTCCCTCACACTTCCTCTC
ACTCAAATAAGAACCTTCCAAAAATGTGTCCACCTGGGCCCCTGCCCTGGGACTCATGGATTTGGAGTTGTGGCCACACGGTTGAGGGGT
GCAGTGTCCAGTGGAATGGGGCAATTGCGGGCCTGGGGGCCCTTGGCCTGTCCGTGGCGGGAGCATCTGCAAGGAGGAGCCCCAGAGTCC
AGGGAGCACTGTGGGGAGCTCCTTAGAGCTGAACTCACCCGGCGTCAACTCATCAACCCTCCACCCATGGACAGGGGTGCCCCCAGCACA
GGAGAGGACTCAGCCCTCTGCCCCCACGCACGGTGGGTGCCTGTCACCCTGTCCTGCCCAGCGGCCCGAGGGCAGCAGTGGGTGTGAGGG
CAGCCCCCGGCCTCCCAAGAGCAGCTGAGAGGATCCCTGCGGGAATCCGGGCTTCGGGTGCATGCGATCTGATCTGAGTTGTTTCTGACA

>33980_33980_2_GOLPH3-SLC6A19_GOLPH3_chr5_32173916_ENST00000265070_SLC6A19_chr5_1219018_ENST00000304460_length(amino acids)=504AA_BP=189
MWQGQTQRAAGPRVAGMCPSDVYAHISTRVHMCVHMCPYACPCVSICAHTYTLACTNAHLPEYAHTRAHITHIYTNRYRHTHIHNTRIHT
RTHAHIYTRHTGIHVHIHMCIYTCKRTHRTHIHTIACMYIHSQIYIYTCMWTPIVRAHVHACIHVCVHTYAHHTQHRHVCLYIHAHTRAA
NIAHMYMHAHLHTHTMSIHVHAHTQHDTSAHMAHAHTIHTPTHMYMCAYTCTLTQCPCMYMHTRYISAHMAHACTIHTLTHEHTLTLTHM
QVQPGPHPTGLAGSSFPDTSVWHAVGWAFSVLQVPVHGGCGQCAHQPLMVPWLLAVVPDELVDGIARDGEGGHSSHNHHHHIHPVRVGDL
LGFGKFLVARVPDAVGQLLTDLYHEEEEEDDQHEQGADHAPRDLPEDVGLVADHELDVLIEPVHTVHVDHREHLAEGDDEQGNGAGIAVQ

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Fusion Gene PPI Analysis for GOLPH3-SLC6A19


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GOLPH3-SLC6A19


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GOLPH3-SLC6A19


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource