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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AKAP9-PPP2R3B (FusionGDB2 ID:3399)

Fusion Gene Summary for AKAP9-PPP2R3B

check button Fusion gene summary
Fusion gene informationFusion gene name: AKAP9-PPP2R3B
Fusion gene ID: 3399
HgeneTgene
Gene symbol

AKAP9

PPP2R3B

Gene ID

10142

28227

Gene nameA-kinase anchoring protein 9protein phosphatase 2 regulatory subunit B''beta
SynonymsAKAP-9|AKAP350|AKAP450|CG-NAP|HYPERION|LQT11|MU-RMS-40.16A|PPP1R45|PRKA9|YOTIAONYREN8|PPP2R3L|PPP2R3LY|PR48|PR70
Cytomap

7q21.2

Xp22.33 and Yp11.31

Type of geneprotein-codingprotein-coding
DescriptionA-kinase anchor protein 9A kinase (PRKA) anchor protein (yotiao) 9A kinase (PRKA) anchor protein 9A-kinase anchor protein 350 kDaA-kinase anchor protein 450 kDaAKAP 120-like proteinAKAP9-BRAF fusion proteincentrosome- and Golgi-localized PKN-associserine/threonine-protein phosphatase 2A regulatory subunit B'' subunit betaNY-REN-8 antigenPP2A, subunit B, PR48 isoformprotein phosphatase 2 (formerly 2A), regulatory subunit B'', betaprotein phosphatase 2, regulatory subunit B'', betaserine/threoni
Modification date2020032820200313
UniProtAcc

Q99996

.
Ensembl transtripts involved in fusion geneENST00000356239, ENST00000358100, 
ENST00000359028, ENST00000394564, 
ENST00000491695, 		ENST00000390665, 
Fusion gene scores* DoF score17 X 21 X 11=39274 X 5 X 4=80
# samples 287
** MAII scorelog2(28/3927*10)=-3.80992886572143
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/80*10)=-0.192645077942396
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AKAP9 [Title/Abstract] AND PPP2R3B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAKAP9(91570461)-PPP2R3B(272325), # samples:2
AKAP9(91570461)-PPP2R3B(322325), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAKAP9

GO:0098962

regulation of postsynaptic neurotransmitter receptor activity

10390370

HgeneAKAP9

GO:1903358

regulation of Golgi organization

27666745


check buttonFusion gene breakpoints across AKAP9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PPP2R3B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-39-5011-01AAKAP9chr7

91570461

+PPP2R3BchrY

272325

-
ChimerDB4LUSCTCGA-39-5011AKAP9chr7

91570461

+PPP2R3BchrX

322325

-
ChimerDB4LUSCTCGA-39-5011AKAP9chr7

91570461

+PPP2R3BchrY

272325

-


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Fusion Gene ORF analysis for AKAP9-PPP2R3B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000356239ENST00000390665AKAP9chr7

91570461

+PPP2R3BchrX

322325

-
5CDS-intronENST00000358100ENST00000390665AKAP9chr7

91570461

+PPP2R3BchrX

322325

-
5CDS-intronENST00000359028ENST00000390665AKAP9chr7

91570461

+PPP2R3BchrX

322325

-
5CDS-intronENST00000394564ENST00000390665AKAP9chr7

91570461

+PPP2R3BchrX

322325

-
In-frameENST00000356239ENST00000390665AKAP9chr7

91570461

+PPP2R3BchrY

272325

-
In-frameENST00000358100ENST00000390665AKAP9chr7

91570461

+PPP2R3BchrY

272325

-
In-frameENST00000359028ENST00000390665AKAP9chr7

91570461

+PPP2R3BchrY

272325

-
In-frameENST00000394564ENST00000390665AKAP9chr7

91570461

+PPP2R3BchrY

272325

-
intron-3CDSENST00000491695ENST00000390665AKAP9chr7

91570461

+PPP2R3BchrY

272325

-
intron-intronENST00000491695ENST00000390665AKAP9chr7

91570461

+PPP2R3BchrX

322325

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356239AKAP9chr791570461+ENST00000390665PPP2R3BchrY272325-20892812031684493
ENST00000358100AKAP9chr791570461+ENST00000390665PPP2R3BchrY272325-20812731951676493
ENST00000359028AKAP9chr791570461+ENST00000390665PPP2R3BchrY272325-20812731951676493
ENST00000394564AKAP9chr791570461+ENST00000390665PPP2R3BchrY272325-20302221441625493

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356239ENST00000390665AKAP9chr791570461+PPP2R3BchrY272325-0.0108076260.9891924
ENST00000358100ENST00000390665AKAP9chr791570461+PPP2R3BchrY272325-0.0107531040.9892469
ENST00000359028ENST00000390665AKAP9chr791570461+PPP2R3BchrY272325-0.0107531040.9892469
ENST00000394564ENST00000390665AKAP9chr791570461+PPP2R3BchrY272325-0.0115863410.98841363

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Fusion Genomic Features for AKAP9-PPP2R3B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AKAP9-PPP2R3B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:91570461/chrY:272325)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AKAP9

Q99996

.
FUNCTION: Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus (PubMed:10202149, PubMed:15047863). Required for microtubule nucleation at the cis-side of the Golgi apparatus (PubMed:15047863, PubMed:19242490). Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:25657325). In complex with PDE4DIP isoform 13/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with PDE4DIP isoform 13/MMG8/SMYLE, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery (PubMed:29162697). {ECO:0000269|PubMed:10202149, ECO:0000269|PubMed:15047863, ECO:0000269|PubMed:19242490, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:29162697}.; FUNCTION: [Isoform 4]: Associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations. {ECO:0000269|PubMed:9482789}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePPP2R3Bchr7:91570461chrY:272325ENST00000390665013401_412108576.0Calcium bindingOntology_term=ECO:0000255
TgenePPP2R3Bchr7:91570461chrY:272325ENST00000390665013388_423108576.0DomainEF-hand

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAKAP9chr7:91570461chrY:272325ENST00000356239+1501088_1173163908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000356239+1501241_1268163908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000356239+1501324_1380163908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000356239+1501422_1447163908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000356239+150152_902163908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000356239+1501573_1647163908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000356239+1501845_2443163908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000356239+1502532_2549163908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000356239+1502591_2764163908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000356239+1503061_3088163908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000356239+1503120_3466163908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000356239+1503583_3685163908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000356239+150932_1010163908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000358100+1491088_1173163858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000358100+1491241_1268163858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000358100+1491324_1380163858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000358100+1491422_1447163858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000358100+149152_902163858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000358100+1491573_1647163858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000358100+1491845_2443163858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000358100+1492532_2549163858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000358100+1492591_2764163858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000358100+1493061_3088163858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000358100+1493120_3466163858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000358100+1493583_3685163858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000358100+149932_1010163858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000359028+1501088_1173163912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000359028+1501241_1268163912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000359028+1501324_1380163912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000359028+1501422_1447163912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000359028+150152_902163912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000359028+1501573_1647163912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000359028+1501845_2443163912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000359028+1502532_2549163912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000359028+1502591_2764163912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000359028+1503061_3088163912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000359028+1503120_3466163912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000359028+1503583_3685163912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000359028+150932_1010163912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91570461chrY:272325ENST00000356239+1501834_2760163908.0Compositional biasNote=Glu-rich
HgeneAKAP9chr7:91570461chrY:272325ENST00000356239+150191_280163908.0Compositional biasNote=Gln-rich
HgeneAKAP9chr7:91570461chrY:272325ENST00000356239+150309_998163908.0Compositional biasNote=Glu-rich
HgeneAKAP9chr7:91570461chrY:272325ENST00000356239+1503722_3726163908.0Compositional biasNote=Poly-Leu
HgeneAKAP9chr7:91570461chrY:272325ENST00000358100+1491834_2760163858.0Compositional biasNote=Glu-rich
HgeneAKAP9chr7:91570461chrY:272325ENST00000358100+149191_280163858.0Compositional biasNote=Gln-rich
HgeneAKAP9chr7:91570461chrY:272325ENST00000358100+149309_998163858.0Compositional biasNote=Glu-rich
HgeneAKAP9chr7:91570461chrY:272325ENST00000358100+1493722_3726163858.0Compositional biasNote=Poly-Leu
HgeneAKAP9chr7:91570461chrY:272325ENST00000359028+1501834_2760163912.0Compositional biasNote=Glu-rich
HgeneAKAP9chr7:91570461chrY:272325ENST00000359028+150191_280163912.0Compositional biasNote=Gln-rich
HgeneAKAP9chr7:91570461chrY:272325ENST00000359028+150309_998163912.0Compositional biasNote=Glu-rich
HgeneAKAP9chr7:91570461chrY:272325ENST00000359028+1503722_3726163912.0Compositional biasNote=Poly-Leu
HgeneAKAP9chr7:91570461chrY:272325ENST00000356239+1502542_2555163908.0RegionNote=PKA-RII subunit binding domain
HgeneAKAP9chr7:91570461chrY:272325ENST00000358100+1492542_2555163858.0RegionNote=PKA-RII subunit binding domain
HgeneAKAP9chr7:91570461chrY:272325ENST00000359028+1502542_2555163912.0RegionNote=PKA-RII subunit binding domain


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Fusion Gene Sequence for AKAP9-PPP2R3B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3399_3399_1_AKAP9-PPP2R3B_AKAP9_chr7_91570461_ENST00000356239_PPP2R3B_chrY_272325_ENST00000390665_length(transcript)=2089nt_BP=281nt
TACGTGGAGACGAAGATGGCGGCGGCGGCGGCGGTGACGGCGCTTCCCGTGCGGCTGAGGACGATCCGCCAGTGAGCGCGGAGACTGCTT
CCACTTCGGGCGGGGGAGCGCCGGACCGAATCGGCTCTCTAGGCCGTGGAGCTTGCCGTCCCACCTCCGTCCAAATCGACCTTTCCTTTC
TATCCCCAACCACCCCTCAACCCCTGTTTTCCCCTGCCTTCCTTGCAGAGGCCATGGAGGACGAGGAGAGACAGAAGAAGCTGGAGGCCG
GCAAAGCCAAGGTTCAGACACGGAAAGAAGAGCCTCTGCCCCCGGCCACGAGCCAAAGCATTCCGACCTTCTACTTCCCCAGAGGACGCC
CGCAGGACTCCGTCAACGTGGATGCCGTCATCAGCAAGATCGAGAGCACCTTCGCCCGGTTCCCCCACGAGAGGGCCACCATGGATGACA
TGGGCCTGGTGGCCAAGGCCTGCGGCTGCCCCCTCTACTGGAAGGGGCCGCTCTTCTATGGCGCCGGCGGGGAGCGCACGGGCTCCGTGT
CCGTCCACAAGTTCGTCGCCATGTGGAGAAAAATCCTCCAGAACTGCCACGACGACGCGGCCAAGTTCGTCCATCTGCTCATGAGCCCCG
GCTGCAACTACCTGGTGCAGGAGGACTTTGTCCCCTTCTTGCAGGACGTGGTGAACACGCACCCGGGGCTGTCGTTCCTGAAGGAGGCGT
CCGAGTTCCACTCGCGCTACATCACCACGGTCATCCAGCGGATCTTCTACGCCGTGAACCGGTCCTGGTCCGGCAGGATCACCTGCGCCG
AGCTGCGGAGGAGCTCCTTCCTGCAGAATGTGGCGCTGCTGGAGGAGGAGGCGGACATCAACCAGCTGACCGAATTCTTCTCGTACGAGC
ATTTCTACGTCATCTACTGCAAGTTCTGGGAGCTGGACACGGACCACGACCTGCTCATCGACGCGGACGACCTGGCGCGGCACAATGACC
ACGCCCTTTCTACCAAGATGATAGACAGGATCTTCTCAGGAGCAGTCACACGAGGCAGAAAAGTGCAGAAGGAAGGGAAGATCAGCTATG
CCGACTTTGTCTGGTTTTTGATCTCTGAGGAAGACAAAAAAACACCGACCAGCATCGAGTACTGGTTCCGCTGCATGGACCTGGACGGGG
ACGGCGCCCTGTCCATGTTCGAGCTCGAGTACTTCTACGAGGAGCAGTGCCGAAGGCTGGACAGCATGGCCATCGAGGCCCTGCCCTTCC
AGGACTGCCTCTGCCAGATGCTGGACCTGGTCAAGCCGAGGACTGAAGGGAAGATCACGCTGCAGGACCTGAAGCGCTGCAAGCTGGCTA
ACGTCTTCTTCGACACCTTCTTCAACATCGAGAAGTACCTCGACCACGAGCAGAAAGAGCAGATCTCCCTGCTCAGGGACGGTGACAGCG
GCGGCCCCGAGCTCTCGGACTGGGAGAAGTACGCGGCCGAGGAGTACGACATCCTGGTGGCCGAGGAGACTGCGGGAGAGCCCTGGGAGG
ACGGGTTCGAGGCCGAGCTCAGCCCTGTGGAGCAGAAGCTGAGTGCGCTGCGCTCCCCGCTGGCCCAGAGGCCCTTCTTCGAGGCGCCCT
CACCGCTGGGCGCCGTGGACCTGTACGAGTACGCATGCGGGGACGAGGACCTGGAGCCGCTGTGACGCCGCCCGCGAGAACGCCGCCGCG
GGGCCGCTCCCCACGTGCCACCACCGGGCCACCGCGGCTCGTGTAAAAACTGTTGTGGAAAATGAGTGCGTTTGTACGGAATGATAAACT
TTTATTTATTCACAGAAGCGTGTTGATTGCCGCTGTGGGTTCGTGGCTGGACCTGCCCAGAGCTCTGTGCCAGGGGGACACGTAGGGCCG
CGCGTGAATGGGACGGGTTCCCACACGGACACCCTCTGGCGCTTGCCGTTCCCGACCCAGCCTGGGTTCCGGGGCCTGCGTCTGTGGAAA
GGGTCCGTGTGCGCACAACGGTGACCGGCGGCTCCCGGGCGCCTCAGTCCTGGACAGGAGCCTCCACCACAGGCTGTGTGAATGTTTTGT

>3399_3399_1_AKAP9-PPP2R3B_AKAP9_chr7_91570461_ENST00000356239_PPP2R3B_chrY_272325_ENST00000390665_length(amino acids)=493AA_BP=26
MFSPAFLAEAMEDEERQKKLEAGKAKVQTRKEEPLPPATSQSIPTFYFPRGRPQDSVNVDAVISKIESTFARFPHERATMDDMGLVAKAC
GCPLYWKGPLFYGAGGERTGSVSVHKFVAMWRKILQNCHDDAAKFVHLLMSPGCNYLVQEDFVPFLQDVVNTHPGLSFLKEASEFHSRYI
TTVIQRIFYAVNRSWSGRITCAELRRSSFLQNVALLEEEADINQLTEFFSYEHFYVIYCKFWELDTDHDLLIDADDLARHNDHALSTKMI
DRIFSGAVTRGRKVQKEGKISYADFVWFLISEEDKKTPTSIEYWFRCMDLDGDGALSMFELEYFYEEQCRRLDSMAIEALPFQDCLCQML
DLVKPRTEGKITLQDLKRCKLANVFFDTFFNIEKYLDHEQKEQISLLRDGDSGGPELSDWEKYAAEEYDILVAEETAGEPWEDGFEAELS

--------------------------------------------------------------
>3399_3399_2_AKAP9-PPP2R3B_AKAP9_chr7_91570461_ENST00000358100_PPP2R3B_chrY_272325_ENST00000390665_length(transcript)=2081nt_BP=273nt
GACGAAGATGGCGGCGGCGGCGGCGGTGACGGCGCTTCCCGTGCGGCTGAGGACGATCCGCCAGTGAGCGCGGAGACTGCTTCCACTTCG
GGCGGGGGAGCGCCGGACCGAATCGGCTCTCTAGGCCGTGGAGCTTGCCGTCCCACCTCCGTCCAAATCGACCTTTCCTTTCTATCCCCA
ACCACCCCTCAACCCCTGTTTTCCCCTGCCTTCCTTGCAGAGGCCATGGAGGACGAGGAGAGACAGAAGAAGCTGGAGGCCGGCAAAGCC
AAGGTTCAGACACGGAAAGAAGAGCCTCTGCCCCCGGCCACGAGCCAAAGCATTCCGACCTTCTACTTCCCCAGAGGACGCCCGCAGGAC
TCCGTCAACGTGGATGCCGTCATCAGCAAGATCGAGAGCACCTTCGCCCGGTTCCCCCACGAGAGGGCCACCATGGATGACATGGGCCTG
GTGGCCAAGGCCTGCGGCTGCCCCCTCTACTGGAAGGGGCCGCTCTTCTATGGCGCCGGCGGGGAGCGCACGGGCTCCGTGTCCGTCCAC
AAGTTCGTCGCCATGTGGAGAAAAATCCTCCAGAACTGCCACGACGACGCGGCCAAGTTCGTCCATCTGCTCATGAGCCCCGGCTGCAAC
TACCTGGTGCAGGAGGACTTTGTCCCCTTCTTGCAGGACGTGGTGAACACGCACCCGGGGCTGTCGTTCCTGAAGGAGGCGTCCGAGTTC
CACTCGCGCTACATCACCACGGTCATCCAGCGGATCTTCTACGCCGTGAACCGGTCCTGGTCCGGCAGGATCACCTGCGCCGAGCTGCGG
AGGAGCTCCTTCCTGCAGAATGTGGCGCTGCTGGAGGAGGAGGCGGACATCAACCAGCTGACCGAATTCTTCTCGTACGAGCATTTCTAC
GTCATCTACTGCAAGTTCTGGGAGCTGGACACGGACCACGACCTGCTCATCGACGCGGACGACCTGGCGCGGCACAATGACCACGCCCTT
TCTACCAAGATGATAGACAGGATCTTCTCAGGAGCAGTCACACGAGGCAGAAAAGTGCAGAAGGAAGGGAAGATCAGCTATGCCGACTTT
GTCTGGTTTTTGATCTCTGAGGAAGACAAAAAAACACCGACCAGCATCGAGTACTGGTTCCGCTGCATGGACCTGGACGGGGACGGCGCC
CTGTCCATGTTCGAGCTCGAGTACTTCTACGAGGAGCAGTGCCGAAGGCTGGACAGCATGGCCATCGAGGCCCTGCCCTTCCAGGACTGC
CTCTGCCAGATGCTGGACCTGGTCAAGCCGAGGACTGAAGGGAAGATCACGCTGCAGGACCTGAAGCGCTGCAAGCTGGCTAACGTCTTC
TTCGACACCTTCTTCAACATCGAGAAGTACCTCGACCACGAGCAGAAAGAGCAGATCTCCCTGCTCAGGGACGGTGACAGCGGCGGCCCC
GAGCTCTCGGACTGGGAGAAGTACGCGGCCGAGGAGTACGACATCCTGGTGGCCGAGGAGACTGCGGGAGAGCCCTGGGAGGACGGGTTC
GAGGCCGAGCTCAGCCCTGTGGAGCAGAAGCTGAGTGCGCTGCGCTCCCCGCTGGCCCAGAGGCCCTTCTTCGAGGCGCCCTCACCGCTG
GGCGCCGTGGACCTGTACGAGTACGCATGCGGGGACGAGGACCTGGAGCCGCTGTGACGCCGCCCGCGAGAACGCCGCCGCGGGGCCGCT
CCCCACGTGCCACCACCGGGCCACCGCGGCTCGTGTAAAAACTGTTGTGGAAAATGAGTGCGTTTGTACGGAATGATAAACTTTTATTTA
TTCACAGAAGCGTGTTGATTGCCGCTGTGGGTTCGTGGCTGGACCTGCCCAGAGCTCTGTGCCAGGGGGACACGTAGGGCCGCGCGTGAA
TGGGACGGGTTCCCACACGGACACCCTCTGGCGCTTGCCGTTCCCGACCCAGCCTGGGTTCCGGGGCCTGCGTCTGTGGAAAGGGTCCGT
GTGCGCACAACGGTGACCGGCGGCTCCCGGGCGCCTCAGTCCTGGACAGGAGCCTCCACCACAGGCTGTGTGAATGTTTTGTGTAAACGT

>3399_3399_2_AKAP9-PPP2R3B_AKAP9_chr7_91570461_ENST00000358100_PPP2R3B_chrY_272325_ENST00000390665_length(amino acids)=493AA_BP=26
MFSPAFLAEAMEDEERQKKLEAGKAKVQTRKEEPLPPATSQSIPTFYFPRGRPQDSVNVDAVISKIESTFARFPHERATMDDMGLVAKAC
GCPLYWKGPLFYGAGGERTGSVSVHKFVAMWRKILQNCHDDAAKFVHLLMSPGCNYLVQEDFVPFLQDVVNTHPGLSFLKEASEFHSRYI
TTVIQRIFYAVNRSWSGRITCAELRRSSFLQNVALLEEEADINQLTEFFSYEHFYVIYCKFWELDTDHDLLIDADDLARHNDHALSTKMI
DRIFSGAVTRGRKVQKEGKISYADFVWFLISEEDKKTPTSIEYWFRCMDLDGDGALSMFELEYFYEEQCRRLDSMAIEALPFQDCLCQML
DLVKPRTEGKITLQDLKRCKLANVFFDTFFNIEKYLDHEQKEQISLLRDGDSGGPELSDWEKYAAEEYDILVAEETAGEPWEDGFEAELS

--------------------------------------------------------------
>3399_3399_3_AKAP9-PPP2R3B_AKAP9_chr7_91570461_ENST00000359028_PPP2R3B_chrY_272325_ENST00000390665_length(transcript)=2081nt_BP=273nt
GACGAAGATGGCGGCGGCGGCGGCGGTGACGGCGCTTCCCGTGCGGCTGAGGACGATCCGCCAGTGAGCGCGGAGACTGCTTCCACTTCG
GGCGGGGGAGCGCCGGACCGAATCGGCTCTCTAGGCCGTGGAGCTTGCCGTCCCACCTCCGTCCAAATCGACCTTTCCTTTCTATCCCCA
ACCACCCCTCAACCCCTGTTTTCCCCTGCCTTCCTTGCAGAGGCCATGGAGGACGAGGAGAGACAGAAGAAGCTGGAGGCCGGCAAAGCC
AAGGTTCAGACACGGAAAGAAGAGCCTCTGCCCCCGGCCACGAGCCAAAGCATTCCGACCTTCTACTTCCCCAGAGGACGCCCGCAGGAC
TCCGTCAACGTGGATGCCGTCATCAGCAAGATCGAGAGCACCTTCGCCCGGTTCCCCCACGAGAGGGCCACCATGGATGACATGGGCCTG
GTGGCCAAGGCCTGCGGCTGCCCCCTCTACTGGAAGGGGCCGCTCTTCTATGGCGCCGGCGGGGAGCGCACGGGCTCCGTGTCCGTCCAC
AAGTTCGTCGCCATGTGGAGAAAAATCCTCCAGAACTGCCACGACGACGCGGCCAAGTTCGTCCATCTGCTCATGAGCCCCGGCTGCAAC
TACCTGGTGCAGGAGGACTTTGTCCCCTTCTTGCAGGACGTGGTGAACACGCACCCGGGGCTGTCGTTCCTGAAGGAGGCGTCCGAGTTC
CACTCGCGCTACATCACCACGGTCATCCAGCGGATCTTCTACGCCGTGAACCGGTCCTGGTCCGGCAGGATCACCTGCGCCGAGCTGCGG
AGGAGCTCCTTCCTGCAGAATGTGGCGCTGCTGGAGGAGGAGGCGGACATCAACCAGCTGACCGAATTCTTCTCGTACGAGCATTTCTAC
GTCATCTACTGCAAGTTCTGGGAGCTGGACACGGACCACGACCTGCTCATCGACGCGGACGACCTGGCGCGGCACAATGACCACGCCCTT
TCTACCAAGATGATAGACAGGATCTTCTCAGGAGCAGTCACACGAGGCAGAAAAGTGCAGAAGGAAGGGAAGATCAGCTATGCCGACTTT
GTCTGGTTTTTGATCTCTGAGGAAGACAAAAAAACACCGACCAGCATCGAGTACTGGTTCCGCTGCATGGACCTGGACGGGGACGGCGCC
CTGTCCATGTTCGAGCTCGAGTACTTCTACGAGGAGCAGTGCCGAAGGCTGGACAGCATGGCCATCGAGGCCCTGCCCTTCCAGGACTGC
CTCTGCCAGATGCTGGACCTGGTCAAGCCGAGGACTGAAGGGAAGATCACGCTGCAGGACCTGAAGCGCTGCAAGCTGGCTAACGTCTTC
TTCGACACCTTCTTCAACATCGAGAAGTACCTCGACCACGAGCAGAAAGAGCAGATCTCCCTGCTCAGGGACGGTGACAGCGGCGGCCCC
GAGCTCTCGGACTGGGAGAAGTACGCGGCCGAGGAGTACGACATCCTGGTGGCCGAGGAGACTGCGGGAGAGCCCTGGGAGGACGGGTTC
GAGGCCGAGCTCAGCCCTGTGGAGCAGAAGCTGAGTGCGCTGCGCTCCCCGCTGGCCCAGAGGCCCTTCTTCGAGGCGCCCTCACCGCTG
GGCGCCGTGGACCTGTACGAGTACGCATGCGGGGACGAGGACCTGGAGCCGCTGTGACGCCGCCCGCGAGAACGCCGCCGCGGGGCCGCT
CCCCACGTGCCACCACCGGGCCACCGCGGCTCGTGTAAAAACTGTTGTGGAAAATGAGTGCGTTTGTACGGAATGATAAACTTTTATTTA
TTCACAGAAGCGTGTTGATTGCCGCTGTGGGTTCGTGGCTGGACCTGCCCAGAGCTCTGTGCCAGGGGGACACGTAGGGCCGCGCGTGAA
TGGGACGGGTTCCCACACGGACACCCTCTGGCGCTTGCCGTTCCCGACCCAGCCTGGGTTCCGGGGCCTGCGTCTGTGGAAAGGGTCCGT
GTGCGCACAACGGTGACCGGCGGCTCCCGGGCGCCTCAGTCCTGGACAGGAGCCTCCACCACAGGCTGTGTGAATGTTTTGTGTAAACGT

>3399_3399_3_AKAP9-PPP2R3B_AKAP9_chr7_91570461_ENST00000359028_PPP2R3B_chrY_272325_ENST00000390665_length(amino acids)=493AA_BP=26
MFSPAFLAEAMEDEERQKKLEAGKAKVQTRKEEPLPPATSQSIPTFYFPRGRPQDSVNVDAVISKIESTFARFPHERATMDDMGLVAKAC
GCPLYWKGPLFYGAGGERTGSVSVHKFVAMWRKILQNCHDDAAKFVHLLMSPGCNYLVQEDFVPFLQDVVNTHPGLSFLKEASEFHSRYI
TTVIQRIFYAVNRSWSGRITCAELRRSSFLQNVALLEEEADINQLTEFFSYEHFYVIYCKFWELDTDHDLLIDADDLARHNDHALSTKMI
DRIFSGAVTRGRKVQKEGKISYADFVWFLISEEDKKTPTSIEYWFRCMDLDGDGALSMFELEYFYEEQCRRLDSMAIEALPFQDCLCQML
DLVKPRTEGKITLQDLKRCKLANVFFDTFFNIEKYLDHEQKEQISLLRDGDSGGPELSDWEKYAAEEYDILVAEETAGEPWEDGFEAELS

--------------------------------------------------------------
>3399_3399_4_AKAP9-PPP2R3B_AKAP9_chr7_91570461_ENST00000394564_PPP2R3B_chrY_272325_ENST00000390665_length(transcript)=2030nt_BP=222nt
GACGATCCGCCAGTGAGCGCGGAGACTGCTTCCACTTCGGGCGGGGGAGCGCCGGACCGAATCGGCTCTCTAGGCCGTGGAGCTTGCCGT
CCCACCTCCGTCCAAATCGACCTTTCCTTTCTATCCCCAACCACCCCTCAACCCCTGTTTTCCCCTGCCTTCCTTGCAGAGGCCATGGAG
GACGAGGAGAGACAGAAGAAGCTGGAGGCCGGCAAAGCCAAGGTTCAGACACGGAAAGAAGAGCCTCTGCCCCCGGCCACGAGCCAAAGC
ATTCCGACCTTCTACTTCCCCAGAGGACGCCCGCAGGACTCCGTCAACGTGGATGCCGTCATCAGCAAGATCGAGAGCACCTTCGCCCGG
TTCCCCCACGAGAGGGCCACCATGGATGACATGGGCCTGGTGGCCAAGGCCTGCGGCTGCCCCCTCTACTGGAAGGGGCCGCTCTTCTAT
GGCGCCGGCGGGGAGCGCACGGGCTCCGTGTCCGTCCACAAGTTCGTCGCCATGTGGAGAAAAATCCTCCAGAACTGCCACGACGACGCG
GCCAAGTTCGTCCATCTGCTCATGAGCCCCGGCTGCAACTACCTGGTGCAGGAGGACTTTGTCCCCTTCTTGCAGGACGTGGTGAACACG
CACCCGGGGCTGTCGTTCCTGAAGGAGGCGTCCGAGTTCCACTCGCGCTACATCACCACGGTCATCCAGCGGATCTTCTACGCCGTGAAC
CGGTCCTGGTCCGGCAGGATCACCTGCGCCGAGCTGCGGAGGAGCTCCTTCCTGCAGAATGTGGCGCTGCTGGAGGAGGAGGCGGACATC
AACCAGCTGACCGAATTCTTCTCGTACGAGCATTTCTACGTCATCTACTGCAAGTTCTGGGAGCTGGACACGGACCACGACCTGCTCATC
GACGCGGACGACCTGGCGCGGCACAATGACCACGCCCTTTCTACCAAGATGATAGACAGGATCTTCTCAGGAGCAGTCACACGAGGCAGA
AAAGTGCAGAAGGAAGGGAAGATCAGCTATGCCGACTTTGTCTGGTTTTTGATCTCTGAGGAAGACAAAAAAACACCGACCAGCATCGAG
TACTGGTTCCGCTGCATGGACCTGGACGGGGACGGCGCCCTGTCCATGTTCGAGCTCGAGTACTTCTACGAGGAGCAGTGCCGAAGGCTG
GACAGCATGGCCATCGAGGCCCTGCCCTTCCAGGACTGCCTCTGCCAGATGCTGGACCTGGTCAAGCCGAGGACTGAAGGGAAGATCACG
CTGCAGGACCTGAAGCGCTGCAAGCTGGCTAACGTCTTCTTCGACACCTTCTTCAACATCGAGAAGTACCTCGACCACGAGCAGAAAGAG
CAGATCTCCCTGCTCAGGGACGGTGACAGCGGCGGCCCCGAGCTCTCGGACTGGGAGAAGTACGCGGCCGAGGAGTACGACATCCTGGTG
GCCGAGGAGACTGCGGGAGAGCCCTGGGAGGACGGGTTCGAGGCCGAGCTCAGCCCTGTGGAGCAGAAGCTGAGTGCGCTGCGCTCCCCG
CTGGCCCAGAGGCCCTTCTTCGAGGCGCCCTCACCGCTGGGCGCCGTGGACCTGTACGAGTACGCATGCGGGGACGAGGACCTGGAGCCG
CTGTGACGCCGCCCGCGAGAACGCCGCCGCGGGGCCGCTCCCCACGTGCCACCACCGGGCCACCGCGGCTCGTGTAAAAACTGTTGTGGA
AAATGAGTGCGTTTGTACGGAATGATAAACTTTTATTTATTCACAGAAGCGTGTTGATTGCCGCTGTGGGTTCGTGGCTGGACCTGCCCA
GAGCTCTGTGCCAGGGGGACACGTAGGGCCGCGCGTGAATGGGACGGGTTCCCACACGGACACCCTCTGGCGCTTGCCGTTCCCGACCCA
GCCTGGGTTCCGGGGCCTGCGTCTGTGGAAAGGGTCCGTGTGCGCACAACGGTGACCGGCGGCTCCCGGGCGCCTCAGTCCTGGACAGGA

>3399_3399_4_AKAP9-PPP2R3B_AKAP9_chr7_91570461_ENST00000394564_PPP2R3B_chrY_272325_ENST00000390665_length(amino acids)=493AA_BP=26
MFSPAFLAEAMEDEERQKKLEAGKAKVQTRKEEPLPPATSQSIPTFYFPRGRPQDSVNVDAVISKIESTFARFPHERATMDDMGLVAKAC
GCPLYWKGPLFYGAGGERTGSVSVHKFVAMWRKILQNCHDDAAKFVHLLMSPGCNYLVQEDFVPFLQDVVNTHPGLSFLKEASEFHSRYI
TTVIQRIFYAVNRSWSGRITCAELRRSSFLQNVALLEEEADINQLTEFFSYEHFYVIYCKFWELDTDHDLLIDADDLARHNDHALSTKMI
DRIFSGAVTRGRKVQKEGKISYADFVWFLISEEDKKTPTSIEYWFRCMDLDGDGALSMFELEYFYEEQCRRLDSMAIEALPFQDCLCQML
DLVKPRTEGKITLQDLKRCKLANVFFDTFFNIEKYLDHEQKEQISLLRDGDSGGPELSDWEKYAAEEYDILVAEETAGEPWEDGFEAELS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AKAP9-PPP2R3B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AKAP9-PPP2R3B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AKAP9-PPP2R3B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource