Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ABCF1-MDGA2 (FusionGDB2 ID:340)

Fusion Gene Summary for ABCF1-MDGA2

Fusion gene summary

Fusion gene information	Fusion gene name: ABCF1-MDGA2
	Fusion gene ID: 340
		Hgene	Tgene
	Gene symbol	ABCF1	MDGA2
	Gene ID	23	161357
	Gene name	ATP binding cassette subfamily F member 1	MAM domain containing glycosylphosphatidylinositol anchor 2
	Synonyms	ABC27\|ABC50	MAMDC1\|c14_5286
	Cytomap	6p21.33	14q21.3
	Type of gene	protein-coding	protein-coding
	Description	ATP-binding cassette sub-family F member 1ATP-binding cassette 50 (TNF-alpha stimulated)ATP-binding cassette, sub-family F (GCN20), member 1TNF-alpha-stimulated ABC proteinTNFalpha-inducible ATP-binding protein	MAM domain-containing glycosylphosphatidylinositol anchor protein 2MAM domain containing 1
	Modification date	20200313	20200313
	UniProtAcc	Q8NE71	Q7Z553
	Ensembl transtripts involved in fusion gene	ENST00000326195, ENST00000376545, ENST00000396515, ENST00000383587, ENST00000383588, ENST00000400609, ENST00000412443, ENST00000416932, ENST00000419893, ENST00000420257, ENST00000421042, ENST00000421608, ENST00000423247, ENST00000426219, ENST00000448939, ENST00000452530, ENST00000454094, ENST00000456791, ENST00000457078, ENST00000457111, ENST00000457970, ENST00000470464, ENST00000475528, ENST00000485585, ENST00000486105, ENST00000494413, ENST00000495194, ENST00000546690, ENST00000552867,	ENST00000357362, ENST00000399222, ENST00000399232, ENST00000426342, ENST00000439988, ENST00000472499,
Fusion gene scores	* DoF score	6 X 5 X 4=120	10 X 10 X 2=200
	# samples	6	10
	** MAII score	log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/200*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ABCF1 [Title/Abstract] AND MDGA2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ABCF1(30558730)-MDGA2(47588363), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ABCF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MDGA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BM145643	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+

Top

Fusion Gene ORF analysis for ABCF1-MDGA2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-intron	ENST00000326195	ENST00000357362	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
3UTR-intron	ENST00000326195	ENST00000399222	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
3UTR-intron	ENST00000326195	ENST00000399232	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
3UTR-intron	ENST00000326195	ENST00000426342	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
3UTR-intron	ENST00000326195	ENST00000439988	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
3UTR-intron	ENST00000326195	ENST00000472499	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
3UTR-intron	ENST00000376545	ENST00000357362	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
3UTR-intron	ENST00000376545	ENST00000399222	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
3UTR-intron	ENST00000376545	ENST00000399232	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
3UTR-intron	ENST00000376545	ENST00000426342	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
3UTR-intron	ENST00000376545	ENST00000439988	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
3UTR-intron	ENST00000376545	ENST00000472499	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
3UTR-intron	ENST00000396515	ENST00000357362	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
3UTR-intron	ENST00000396515	ENST00000399222	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
3UTR-intron	ENST00000396515	ENST00000399232	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
3UTR-intron	ENST00000396515	ENST00000426342	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
3UTR-intron	ENST00000396515	ENST00000439988	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
3UTR-intron	ENST00000396515	ENST00000472499	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000383587	ENST00000357362	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000383587	ENST00000399222	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000383587	ENST00000399232	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000383587	ENST00000426342	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000383587	ENST00000439988	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000383587	ENST00000472499	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000383588	ENST00000357362	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000383588	ENST00000399222	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000383588	ENST00000399232	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000383588	ENST00000426342	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000383588	ENST00000439988	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000383588	ENST00000472499	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000400609	ENST00000357362	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000400609	ENST00000399222	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000400609	ENST00000399232	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000400609	ENST00000426342	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000400609	ENST00000439988	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000400609	ENST00000472499	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000412443	ENST00000357362	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000412443	ENST00000399222	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000412443	ENST00000399232	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000412443	ENST00000426342	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000412443	ENST00000439988	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000412443	ENST00000472499	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000416932	ENST00000357362	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000416932	ENST00000399222	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000416932	ENST00000399232	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000416932	ENST00000426342	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000416932	ENST00000439988	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000416932	ENST00000472499	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000419893	ENST00000357362	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000419893	ENST00000399222	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000419893	ENST00000399232	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000419893	ENST00000426342	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000419893	ENST00000439988	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000419893	ENST00000472499	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000420257	ENST00000357362	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000420257	ENST00000399222	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000420257	ENST00000399232	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000420257	ENST00000426342	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000420257	ENST00000439988	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000420257	ENST00000472499	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000421042	ENST00000357362	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000421042	ENST00000399222	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000421042	ENST00000399232	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000421042	ENST00000426342	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000421042	ENST00000439988	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000421042	ENST00000472499	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000421608	ENST00000357362	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000421608	ENST00000399222	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000421608	ENST00000399232	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000421608	ENST00000426342	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000421608	ENST00000439988	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000421608	ENST00000472499	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000423247	ENST00000357362	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000423247	ENST00000399222	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000423247	ENST00000399232	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000423247	ENST00000426342	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000423247	ENST00000439988	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000423247	ENST00000472499	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000426219	ENST00000357362	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000426219	ENST00000399222	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000426219	ENST00000399232	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000426219	ENST00000426342	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000426219	ENST00000439988	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000426219	ENST00000472499	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000448939	ENST00000357362	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000448939	ENST00000399222	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000448939	ENST00000399232	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000448939	ENST00000426342	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000448939	ENST00000439988	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000448939	ENST00000472499	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000452530	ENST00000357362	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000452530	ENST00000399222	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000452530	ENST00000399232	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000452530	ENST00000426342	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000452530	ENST00000439988	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000452530	ENST00000472499	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000454094	ENST00000357362	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000454094	ENST00000399222	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000454094	ENST00000399232	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000454094	ENST00000426342	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000454094	ENST00000439988	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000454094	ENST00000472499	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000456791	ENST00000357362	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000456791	ENST00000399222	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000456791	ENST00000399232	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000456791	ENST00000426342	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000456791	ENST00000439988	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000456791	ENST00000472499	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000457078	ENST00000357362	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000457078	ENST00000399222	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000457078	ENST00000399232	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000457078	ENST00000426342	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000457078	ENST00000439988	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000457078	ENST00000472499	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000457111	ENST00000357362	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000457111	ENST00000399222	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000457111	ENST00000399232	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000457111	ENST00000426342	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000457111	ENST00000439988	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000457111	ENST00000472499	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000457970	ENST00000357362	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000457970	ENST00000399222	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000457970	ENST00000399232	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000457970	ENST00000426342	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000457970	ENST00000439988	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000457970	ENST00000472499	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000470464	ENST00000357362	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000470464	ENST00000399222	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000470464	ENST00000399232	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000470464	ENST00000426342	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000470464	ENST00000439988	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000470464	ENST00000472499	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000475528	ENST00000357362	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000475528	ENST00000399222	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000475528	ENST00000399232	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000475528	ENST00000426342	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000475528	ENST00000439988	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000475528	ENST00000472499	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000485585	ENST00000357362	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000485585	ENST00000399222	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000485585	ENST00000399232	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000485585	ENST00000426342	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000485585	ENST00000439988	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000485585	ENST00000472499	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000486105	ENST00000357362	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000486105	ENST00000399222	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000486105	ENST00000399232	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000486105	ENST00000426342	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000486105	ENST00000439988	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000486105	ENST00000472499	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000494413	ENST00000357362	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000494413	ENST00000399222	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000494413	ENST00000399232	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000494413	ENST00000426342	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000494413	ENST00000439988	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000494413	ENST00000472499	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000495194	ENST00000357362	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000495194	ENST00000399222	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000495194	ENST00000399232	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000495194	ENST00000426342	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000495194	ENST00000439988	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000495194	ENST00000472499	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000546690	ENST00000357362	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000546690	ENST00000399222	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000546690	ENST00000399232	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000546690	ENST00000426342	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000546690	ENST00000439988	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000546690	ENST00000472499	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000552867	ENST00000357362	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000552867	ENST00000399222	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000552867	ENST00000399232	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000552867	ENST00000426342	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000552867	ENST00000439988	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+
intron-intron	ENST00000552867	ENST00000472499	ABCF1	chr6	30558730	-	MDGA2	chr14	47588363	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for ABCF1-MDGA2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ABCF1-MDGA2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:30558730/:47588363)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ABCF1 Q8NE71	MDGA2 Q7Z553
FUNCTION: Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis. {ECO:0000269\|PubMed:19570978}.	FUNCTION: May be involved in cell-cell interactions. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Gene Sequence for ABCF1-MDGA2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for ABCF1-MDGA2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ABCF1-MDGA2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ABCF1-MDGA2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source