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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GORASP2-GAD1 (FusionGDB2 ID:34020)

Fusion Gene Summary for GORASP2-GAD1

check button Fusion gene summary
Fusion gene informationFusion gene name: GORASP2-GAD1
Fusion gene ID: 34020
HgeneTgene
Gene symbol

GORASP2

GAD1

Gene ID

26003

2571

Gene namegolgi reassembly stacking protein 2glutamate decarboxylase 1
SynonymsGOLPH6|GRASP55|GRS2|p59CPSQ1|GAD|SCP
Cytomap

2q31.1

2q31.1

Type of geneprotein-codingprotein-coding
DescriptionGolgi reassembly-stacking protein 2golgi phosphoprotein 6golgi reassembly stacking protein 2, 55kDaglutamate decarboxylase 167 kDa glutamic acid decarboxylaseGAD-67glutamate decarboxylase 1 (brain, 67kDa)glutamate decarboxylase 67 kDa isoform
Modification date2020032720200315
UniProtAcc

Q9H8Y8

Q99259

Ensembl transtripts involved in fusion geneENST00000493692, ENST00000234160, 
ENST00000452526, 		ENST00000358196, 
ENST00000344257, ENST00000375272, 
ENST00000429023, 
Fusion gene scores* DoF score8 X 5 X 5=2003 X 4 X 3=36
# samples 93
** MAII scorelog2(9/200*10)=-1.15200309344505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/36*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GORASP2 [Title/Abstract] AND GAD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGORASP2(171804940)-GAD1(171704186), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGORASP2

GO:0034976

response to endoplasmic reticulum stress

21884936|27062250|28067262

HgeneGORASP2

GO:0061951

establishment of protein localization to plasma membrane

28067262


check buttonFusion gene breakpoints across GORASP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GAD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-61-2009-01AGORASP2chr2

171804940

+GAD1chr2

171704186

+
ChimerDB4OVTCGA-61-2009-01AGORASP2chr2

171804940

+GAD1chr2

171705796

+


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Fusion Gene ORF analysis for GORASP2-GAD1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000493692ENST00000358196GORASP2chr2

171804940

+GAD1chr2

171704186

+
3UTR-3CDSENST00000493692ENST00000358196GORASP2chr2

171804940

+GAD1chr2

171705796

+
3UTR-intronENST00000493692ENST00000344257GORASP2chr2

171804940

+GAD1chr2

171704186

+
3UTR-intronENST00000493692ENST00000344257GORASP2chr2

171804940

+GAD1chr2

171705796

+
3UTR-intronENST00000493692ENST00000375272GORASP2chr2

171804940

+GAD1chr2

171704186

+
3UTR-intronENST00000493692ENST00000375272GORASP2chr2

171804940

+GAD1chr2

171705796

+
3UTR-intronENST00000493692ENST00000429023GORASP2chr2

171804940

+GAD1chr2

171704186

+
3UTR-intronENST00000493692ENST00000429023GORASP2chr2

171804940

+GAD1chr2

171705796

+
5CDS-intronENST00000234160ENST00000344257GORASP2chr2

171804940

+GAD1chr2

171704186

+
5CDS-intronENST00000234160ENST00000344257GORASP2chr2

171804940

+GAD1chr2

171705796

+
5CDS-intronENST00000234160ENST00000375272GORASP2chr2

171804940

+GAD1chr2

171704186

+
5CDS-intronENST00000234160ENST00000375272GORASP2chr2

171804940

+GAD1chr2

171705796

+
5CDS-intronENST00000234160ENST00000429023GORASP2chr2

171804940

+GAD1chr2

171704186

+
5CDS-intronENST00000234160ENST00000429023GORASP2chr2

171804940

+GAD1chr2

171705796

+
5CDS-intronENST00000452526ENST00000344257GORASP2chr2

171804940

+GAD1chr2

171704186

+
5CDS-intronENST00000452526ENST00000344257GORASP2chr2

171804940

+GAD1chr2

171705796

+
5CDS-intronENST00000452526ENST00000375272GORASP2chr2

171804940

+GAD1chr2

171704186

+
5CDS-intronENST00000452526ENST00000375272GORASP2chr2

171804940

+GAD1chr2

171705796

+
5CDS-intronENST00000452526ENST00000429023GORASP2chr2

171804940

+GAD1chr2

171704186

+
5CDS-intronENST00000452526ENST00000429023GORASP2chr2

171804940

+GAD1chr2

171705796

+
In-frameENST00000234160ENST00000358196GORASP2chr2

171804940

+GAD1chr2

171704186

+
In-frameENST00000234160ENST00000358196GORASP2chr2

171804940

+GAD1chr2

171705796

+
In-frameENST00000452526ENST00000358196GORASP2chr2

171804940

+GAD1chr2

171704186

+
In-frameENST00000452526ENST00000358196GORASP2chr2

171804940

+GAD1chr2

171705796

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000234160GORASP2chr2171804940+ENST00000358196GAD1chr2171704186+30119595181741407
ENST00000452526GORASP2chr2171804940+ENST00000358196GAD1chr2171704186+2320268881050320

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000234160ENST00000358196GORASP2chr2171804940+GAD1chr2171704186+0.0019518230.9980482
ENST00000452526ENST00000358196GORASP2chr2171804940+GAD1chr2171704186+0.0003294280.9996706

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Fusion Genomic Features for GORASP2-GAD1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GORASP2chr2171804940+GAD1chr2171704185+0.00214720.9978528
GORASP2chr2171804940+GAD1chr2171705795+1.84E-060.9999982
GORASP2chr2171804940+GAD1chr2171704185+0.00214720.9978528
GORASP2chr2171804940+GAD1chr2171705795+1.84E-060.9999982

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GORASP2-GAD1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:171804940/chr2:171704186)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GORASP2

Q9H8Y8

GAD1

Q99259

FUNCTION: Plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (PubMed:10487747, PubMed:21515684, PubMed:22523075). May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (PubMed:11101516). Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (By similarity). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936, PubMed:27062250, PubMed:28067262). {ECO:0000250|UniProtKB:Q99JX3, ECO:0000269|PubMed:10487747, ECO:0000269|PubMed:11101516, ECO:0000269|PubMed:21515684, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:22523075, ECO:0000269|PubMed:27062250, ECO:0000269|PubMed:28067262}.FUNCTION: Catalyzes the production of GABA.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGAD1chr2:171804940chr2:171704186ENST0000034425707190_1920225.0RegionNote=Substrate binding
TgeneGAD1chr2:171804940chr2:171704186ENST0000037527207190_1920225.0RegionNote=Substrate binding
TgeneGAD1chr2:171804940chr2:171705796ENST0000034425707190_1920225.0RegionNote=Substrate binding
TgeneGAD1chr2:171804940chr2:171705796ENST0000037527207190_1920225.0RegionNote=Substrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGORASP2chr2:171804940chr2:171704186ENST00000234160+210277_37248453.0Compositional biasNote=Pro-rich
HgeneGORASP2chr2:171804940chr2:171705796ENST00000234160+210277_37248453.0Compositional biasNote=Pro-rich
HgeneGORASP2chr2:171804940chr2:171704186ENST00000234160+210111_19948453.0DomainPDZ GRASP-type 2
HgeneGORASP2chr2:171804940chr2:171704186ENST00000234160+21015_10548453.0DomainPDZ GRASP-type 1
HgeneGORASP2chr2:171804940chr2:171705796ENST00000234160+210111_19948453.0DomainPDZ GRASP-type 2
HgeneGORASP2chr2:171804940chr2:171705796ENST00000234160+21015_10548453.0DomainPDZ GRASP-type 1
HgeneGORASP2chr2:171804940chr2:171704186ENST00000234160+21015_21548453.0RegionGRASP
HgeneGORASP2chr2:171804940chr2:171704186ENST00000234160+210194_19948453.0RegionNote=Important for membrane binding
HgeneGORASP2chr2:171804940chr2:171705796ENST00000234160+21015_21548453.0RegionGRASP
HgeneGORASP2chr2:171804940chr2:171705796ENST00000234160+210194_19948453.0RegionNote=Important for membrane binding
TgeneGAD1chr2:171804940chr2:171704186ENST00000358196917190_192334595.0RegionNote=Substrate binding
TgeneGAD1chr2:171804940chr2:171705796ENST000003581961017190_192373595.0RegionNote=Substrate binding


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Fusion Gene Sequence for GORASP2-GAD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>34020_34020_1_GORASP2-GAD1_GORASP2_chr2_171804940_ENST00000234160_GAD1_chr2_171704186_ENST00000358196_length(transcript)=3011nt_BP=959nt
AATAAGCATGAATACGACCTGGCTACCTGAAGGAGGTAGGACGGGGAACCGAGCAGCAGCAGGTGGTGGAATGCCAGGGAAATCCAACCG
TGCTTCCCACGCTGGCATCGCTCTGATTATGACCAATCCTCTAATCTTATTCTCACAATTAGGGAGGAAGAAAAAAAAACAAACCCAAAC
CAAAAAAGAAGTTGGTAGGTGACTCTGTGAGACTACTGTTTTATAAAGGGAGCGTTTCCTTTTATAAAATTTAGCTGAGCAGATGCTAGG
CAGCCCACAGGAGGCCACTATTCCCCTCAGCTGTACAGTTTGGGAAAATACCTACACACCCGGAGAACAGAGAGCTTGGTGTGTGTTGAG
TTCGCTCCTGTTCATCAGCAGCCCTTTCCCCGCCTCTGGCCACCAGGGGGACCTGCAACCAAGTATGTGTTCTTTCAGGCGAGCGGGAAC
GCGTCTGCATAAATCTAGTCCAATCCAGGGCCCCGTAGCAAGGCGCCAAAGCTGGGGGAAGCGCATTTCTGTTCTCTCGCGAGCACGACG
CGGTGCCTCCCAGTCCTCCTCCGGCCCTCCCTCTCCGCCCTCCCGGCCCGCGAGCGCTCGGGCCCCTTCCAGTGGCTCGCGGCAGGTGGC
GCTGTCTGCGGCGTCGCAGCGGCCCGGGCTGCAGCAGAGACGATCTCCCGGCGGGCTGTGCGGCCCGGCTCTCCGGCGGCAGCGAGTGCC
ACGTCCCAAGTGCTACGCGGAGGATTAGAGCAGGCGGTGCGCTGGGGGCGGGAGCAGCGCGGAGCCCGGCTCGGCCACACCGATCGCCCG
CCGCCATGGGCTCCTCGCAAAGCGTCGAGATCCCGGGCGGGGGCACCGAGGGCTACCACGTTCTGCGGGTACAAGAAAATTCCCCAGGAC
ACAGAGCTGGTTTGGAGCCTTTCTTTGATTTTATTGTTTCTATTAATGGTTCAAGATTAGGATATGTTCCCTTTTATGTCAATGCAACTG
CTGGCACGACTGTTTATGGAGCTTTTGATCCGATACAAGAGATTGCAGATATATGTGAGAAATATAACCTTTGGTTGCATGTCGATGCTG
CCTGGGGAGGTGGGCTGCTCATGTCCAGGAAGCACCGCCATAAACTCAACGGCATAGAAAGGGCCAACTCAGTCACCTGGAACCCTCACA
AGATGATGGGCGTGCTGTTGCAGTGCTCTGCCATTCTCGTCAAGGAAAAGGGTATACTCCAAGGATGCAACCAGATGTGTGCAGGATACC
TCTTCCAGCCAGACAAGCAGTATGATGTCTCCTACGACACCGGGGACAAGGCAATTCAGTGTGGCCGCCACGTGGATATCTTCAAGTTCT
GGCTGATGTGGAAAGCAAAGGGCACAGTGGGATTTGAAAACCAGATCAACAAATGCCTGGAACTGGCTGAATACCTCTATGCCAAGATTA
AAAACAGAGAAGAATTTGAGATGGTTTTCAATGGCGAGCCTGAGCACACAAACGTCTGTTTTTGGTATATTCCACAAAGCCTCAGGGGTG
TGCCAGACAGCCCTCAACGACGGGAAAAGCTACACAAGGTGGCTCCAAAAATCAAAGCCCTGATGATGGAGTCAGGTACGACCATGGTTG
GCTACCAGCCCCAAGGGGACAAGGCCAACTTCTTCCGGATGGTCATCTCCAACCCAGCCGCTACCCAGTCTGACATTGACTTCCTCATTG
AGGAGATAGAAAGACTGGGCCAGGATCTGTAATCATCCTTCGCAGAACATGAGTTTATGGGAATGCCTTTTCCCTCTGGCACTCCAGAAC
AAACCTCTATATGTTGCTGAAACACACAGGCCATTTCATTGAGGGAAAACATAATATCTTGAAGAATATTGTTAAAACCTTACTTAAAGC
TTGTTTGTTCTAGTTAGCAGGAAATAGTGTTCTTTTTAAAAAGTTGCACATTAGGAACAGAGTATATATGTACAGTTATACATACCTCTC
TCTATATATACATGTATAGTGAGTGTGGCTTAGTAATAGATCACGGCATGTTTCCCGCTCCAAGAGAATTCACTTTACCTTCAGCAGTTA
CCGAGGAGCTAAACATGCTGCCAACCAGCTTGTCCAACAACTCCAGGAAAACTGTTTTTCAAAACGCCATGTCCTAGGGGCCGAGGGAAA
TGCTGTTGGTGAGAATCGACCTCACTGTCAGCGTTTCTCCACCTGAAGTGATGATGGATGAGAAAAAACACCACCAAATGACAAGTCACA
CCCTCCCCATTAGTATCCTGTTAGGGGAAAATAGTAGCAGAGTCATTGTTACAGGTGTACTATGGCTGTATTTTTAGAGATTAATTTGTG
TAGATTGTGTAAATTCCTGTTGTCTGACCTTGGTGGTGGGAGGGGGAGACTATGTGTCATGATTTCAATGATTGTTTAATTGTAGGTCAA
TGAAATATTTGCTTATTTATATTCAGAGATGTACCATGTTAAAGAGGCGTCTTGTATTTTCTTCCCATTTGTAATGTATCTTATTTATAT
ATGAAGTAAGTTCTGAAAACTGTTTATGGTATTTTCGTGCATTTGTGAGCCAAAGAGAAAAGATTAAAATTAGTGAGATTTGTATTTATA
TTAGAGTGCCCTTAAAATAATGATTTAAGCATTTTACTGTCTGTAAGAGAATTCTAAGATTGTACATAAAGTCATATATATGGAAATCCT
GTTACTTAAATAGCATCTGCTCTTCTCTTACGCTCTCTGTCTGGCTGTACGTCTGGTGTTCTCAATGCTTTTCTAGCAACTGTTGGATAA
TAACTAGATCTCCTGTAATTTTGTAGTAGTTGATGACCAATCTCTGTGACTCGCTTAGCTGAAACCTAAGGCAACATTTCCGAAGACCTT
CTGAAGATCTCAGATAAAGTGACCAGGCTCACAACTGTTTTTGAAGAAGGGAAATTCACACTGTGCGTTTTAGAGTATGCAAGAAGAATA

>34020_34020_1_GORASP2-GAD1_GORASP2_chr2_171804940_ENST00000234160_GAD1_chr2_171704186_ENST00000358196_length(amino acids)=407AA_BP=147
MFSREHDAVPPSPPPALPLRPPGPRALGPLPVARGRWRCLRRRSGPGCSRDDLPAGCAARLSGGSECHVPSATRRIRAGGALGAGAARSP
ARPHRSPAAMGSSQSVEIPGGGTEGYHVLRVQENSPGHRAGLEPFFDFIVSINGSRLGYVPFYVNATAGTTVYGAFDPIQEIADICEKYN
LWLHVDAAWGGGLLMSRKHRHKLNGIERANSVTWNPHKMMGVLLQCSAILVKEKGILQGCNQMCAGYLFQPDKQYDVSYDTGDKAIQCGR
HVDIFKFWLMWKAKGTVGFENQINKCLELAEYLYAKIKNREEFEMVFNGEPEHTNVCFWYIPQSLRGVPDSPQRREKLHKVAPKIKALMM

--------------------------------------------------------------
>34020_34020_2_GORASP2-GAD1_GORASP2_chr2_171804940_ENST00000452526_GAD1_chr2_171704186_ENST00000358196_length(transcript)=2320nt_BP=268nt
CACACCGATCGCCCGCCGCCATGGGCTCCTCGCAAAGCGTCGAGATCCCGGGCGGGGGCACCGAGGGCTACCACGTTCTGCGGCATCAAT
GAGAGAAGGCTCAAGCACATTGTCAGAAATAAGGAAGCTTAAGCCGGGCATAATGGTGTGCACCTGTAATCCCAGCTACTCCAATCAGGA
GACTGAGGTACAAGAAAATTCCCCAGGACACAGAGCTGGTTTGGAGCCTTTCTTTGATTTTATTGTTTCTATTAATGGTTCAAGATTAGG
ATATGTTCCCTTTTATGTCAATGCAACTGCTGGCACGACTGTTTATGGAGCTTTTGATCCGATACAAGAGATTGCAGATATATGTGAGAA
ATATAACCTTTGGTTGCATGTCGATGCTGCCTGGGGAGGTGGGCTGCTCATGTCCAGGAAGCACCGCCATAAACTCAACGGCATAGAAAG
GGCCAACTCAGTCACCTGGAACCCTCACAAGATGATGGGCGTGCTGTTGCAGTGCTCTGCCATTCTCGTCAAGGAAAAGGGTATACTCCA
AGGATGCAACCAGATGTGTGCAGGATACCTCTTCCAGCCAGACAAGCAGTATGATGTCTCCTACGACACCGGGGACAAGGCAATTCAGTG
TGGCCGCCACGTGGATATCTTCAAGTTCTGGCTGATGTGGAAAGCAAAGGGCACAGTGGGATTTGAAAACCAGATCAACAAATGCCTGGA
ACTGGCTGAATACCTCTATGCCAAGATTAAAAACAGAGAAGAATTTGAGATGGTTTTCAATGGCGAGCCTGAGCACACAAACGTCTGTTT
TTGGTATATTCCACAAAGCCTCAGGGGTGTGCCAGACAGCCCTCAACGACGGGAAAAGCTACACAAGGTGGCTCCAAAAATCAAAGCCCT
GATGATGGAGTCAGGTACGACCATGGTTGGCTACCAGCCCCAAGGGGACAAGGCCAACTTCTTCCGGATGGTCATCTCCAACCCAGCCGC
TACCCAGTCTGACATTGACTTCCTCATTGAGGAGATAGAAAGACTGGGCCAGGATCTGTAATCATCCTTCGCAGAACATGAGTTTATGGG
AATGCCTTTTCCCTCTGGCACTCCAGAACAAACCTCTATATGTTGCTGAAACACACAGGCCATTTCATTGAGGGAAAACATAATATCTTG
AAGAATATTGTTAAAACCTTACTTAAAGCTTGTTTGTTCTAGTTAGCAGGAAATAGTGTTCTTTTTAAAAAGTTGCACATTAGGAACAGA
GTATATATGTACAGTTATACATACCTCTCTCTATATATACATGTATAGTGAGTGTGGCTTAGTAATAGATCACGGCATGTTTCCCGCTCC
AAGAGAATTCACTTTACCTTCAGCAGTTACCGAGGAGCTAAACATGCTGCCAACCAGCTTGTCCAACAACTCCAGGAAAACTGTTTTTCA
AAACGCCATGTCCTAGGGGCCGAGGGAAATGCTGTTGGTGAGAATCGACCTCACTGTCAGCGTTTCTCCACCTGAAGTGATGATGGATGA
GAAAAAACACCACCAAATGACAAGTCACACCCTCCCCATTAGTATCCTGTTAGGGGAAAATAGTAGCAGAGTCATTGTTACAGGTGTACT
ATGGCTGTATTTTTAGAGATTAATTTGTGTAGATTGTGTAAATTCCTGTTGTCTGACCTTGGTGGTGGGAGGGGGAGACTATGTGTCATG
ATTTCAATGATTGTTTAATTGTAGGTCAATGAAATATTTGCTTATTTATATTCAGAGATGTACCATGTTAAAGAGGCGTCTTGTATTTTC
TTCCCATTTGTAATGTATCTTATTTATATATGAAGTAAGTTCTGAAAACTGTTTATGGTATTTTCGTGCATTTGTGAGCCAAAGAGAAAA
GATTAAAATTAGTGAGATTTGTATTTATATTAGAGTGCCCTTAAAATAATGATTTAAGCATTTTACTGTCTGTAAGAGAATTCTAAGATT
GTACATAAAGTCATATATATGGAAATCCTGTTACTTAAATAGCATCTGCTCTTCTCTTACGCTCTCTGTCTGGCTGTACGTCTGGTGTTC
TCAATGCTTTTCTAGCAACTGTTGGATAATAACTAGATCTCCTGTAATTTTGTAGTAGTTGATGACCAATCTCTGTGACTCGCTTAGCTG
AAACCTAAGGCAACATTTCCGAAGACCTTCTGAAGATCTCAGATAAAGTGACCAGGCTCACAACTGTTTTTGAAGAAGGGAAATTCACAC

>34020_34020_2_GORASP2-GAD1_GORASP2_chr2_171804940_ENST00000452526_GAD1_chr2_171704186_ENST00000358196_length(amino acids)=320AA_BP=60
MREGSSTLSEIRKLKPGIMVCTCNPSYSNQETEVQENSPGHRAGLEPFFDFIVSINGSRLGYVPFYVNATAGTTVYGAFDPIQEIADICE
KYNLWLHVDAAWGGGLLMSRKHRHKLNGIERANSVTWNPHKMMGVLLQCSAILVKEKGILQGCNQMCAGYLFQPDKQYDVSYDTGDKAIQ
CGRHVDIFKFWLMWKAKGTVGFENQINKCLELAEYLYAKIKNREEFEMVFNGEPEHTNVCFWYIPQSLRGVPDSPQRREKLHKVAPKIKA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GORASP2-GAD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GORASP2-GAD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GORASP2-GAD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource