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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GORASP2-MYO3B (FusionGDB2 ID:34023)

Fusion Gene Summary for GORASP2-MYO3B

check button Fusion gene summary
Fusion gene informationFusion gene name: GORASP2-MYO3B
Fusion gene ID: 34023
HgeneTgene
Gene symbol

GORASP2

MYO3B

Gene ID

26003

140469

Gene namegolgi reassembly stacking protein 2myosin IIIB
SynonymsGOLPH6|GRASP55|GRS2|p59-
Cytomap

2q31.1

2q31.1

Type of geneprotein-codingprotein-coding
DescriptionGolgi reassembly-stacking protein 2golgi phosphoprotein 6golgi reassembly stacking protein 2, 55kDamyosin-IIIb
Modification date2020032720200320
UniProtAcc

Q9H8Y8

Q8WXR4

Ensembl transtripts involved in fusion geneENST00000493692, ENST00000234160, 
ENST00000452526, 		ENST00000334231, 
ENST00000408978, ENST00000409044, 
ENST00000602629, 
Fusion gene scores* DoF score8 X 5 X 5=2004 X 5 X 3=60
# samples 95
** MAII scorelog2(9/200*10)=-1.15200309344505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GORASP2 [Title/Abstract] AND MYO3B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGORASP2(171785913)-MYO3B(171508138), # samples:2
Anticipated loss of major functional domain due to fusion event.GORASP2-MYO3B seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
GORASP2-MYO3B seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGORASP2

GO:0034976

response to endoplasmic reticulum stress

21884936|27062250|28067262

HgeneGORASP2

GO:0061951

establishment of protein localization to plasma membrane

28067262


check buttonFusion gene breakpoints across GORASP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MYO3B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-2297-01AGORASP2chr2

171785913

+MYO3Bchr2

171508138

+
ChimerDB4OVTCGA-24-2297GORASP2chr2

171785913

+MYO3Bchr2

171508137

+


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Fusion Gene ORF analysis for GORASP2-MYO3B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000493692ENST00000334231GORASP2chr2

171785913

+MYO3Bchr2

171508138

+
3UTR-3CDSENST00000493692ENST00000334231GORASP2chr2

171785913

+MYO3Bchr2

171508137

+
3UTR-3CDSENST00000493692ENST00000408978GORASP2chr2

171785913

+MYO3Bchr2

171508138

+
3UTR-3CDSENST00000493692ENST00000408978GORASP2chr2

171785913

+MYO3Bchr2

171508137

+
3UTR-3CDSENST00000493692ENST00000409044GORASP2chr2

171785913

+MYO3Bchr2

171508138

+
3UTR-3CDSENST00000493692ENST00000409044GORASP2chr2

171785913

+MYO3Bchr2

171508137

+
3UTR-3UTRENST00000493692ENST00000602629GORASP2chr2

171785913

+MYO3Bchr2

171508138

+
3UTR-3UTRENST00000493692ENST00000602629GORASP2chr2

171785913

+MYO3Bchr2

171508137

+
5CDS-3UTRENST00000234160ENST00000602629GORASP2chr2

171785913

+MYO3Bchr2

171508138

+
5CDS-3UTRENST00000234160ENST00000602629GORASP2chr2

171785913

+MYO3Bchr2

171508137

+
5UTR-3CDSENST00000452526ENST00000334231GORASP2chr2

171785913

+MYO3Bchr2

171508138

+
5UTR-3CDSENST00000452526ENST00000334231GORASP2chr2

171785913

+MYO3Bchr2

171508137

+
5UTR-3CDSENST00000452526ENST00000408978GORASP2chr2

171785913

+MYO3Bchr2

171508138

+
5UTR-3CDSENST00000452526ENST00000408978GORASP2chr2

171785913

+MYO3Bchr2

171508137

+
5UTR-3CDSENST00000452526ENST00000409044GORASP2chr2

171785913

+MYO3Bchr2

171508138

+
5UTR-3CDSENST00000452526ENST00000409044GORASP2chr2

171785913

+MYO3Bchr2

171508137

+
5UTR-3UTRENST00000452526ENST00000602629GORASP2chr2

171785913

+MYO3Bchr2

171508138

+
5UTR-3UTRENST00000452526ENST00000602629GORASP2chr2

171785913

+MYO3Bchr2

171508137

+
Frame-shiftENST00000234160ENST00000334231GORASP2chr2

171785913

+MYO3Bchr2

171508138

+
Frame-shiftENST00000234160ENST00000334231GORASP2chr2

171785913

+MYO3Bchr2

171508137

+
Frame-shiftENST00000234160ENST00000408978GORASP2chr2

171785913

+MYO3Bchr2

171508138

+
Frame-shiftENST00000234160ENST00000408978GORASP2chr2

171785913

+MYO3Bchr2

171508137

+
Frame-shiftENST00000234160ENST00000409044GORASP2chr2

171785913

+MYO3Bchr2

171508138

+
Frame-shiftENST00000234160ENST00000409044GORASP2chr2

171785913

+MYO3Bchr2

171508137

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for GORASP2-MYO3B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GORASP2chr2171785913+MYO3Bchr2171508137+4.15E-050.9999585
GORASP2chr2171785913+MYO3Bchr2171508137+4.15E-050.9999585
GORASP2chr2171785913+MYO3Bchr2171508137+4.15E-050.9999585
GORASP2chr2171785913+MYO3Bchr2171508137+4.15E-050.9999585

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GORASP2-MYO3B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:171785913/:171508138)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GORASP2

Q9H8Y8

MYO3B

Q8WXR4

FUNCTION: Plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (PubMed:10487747, PubMed:21515684, PubMed:22523075). May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (PubMed:11101516). Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (By similarity). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936, PubMed:27062250, PubMed:28067262). {ECO:0000250|UniProtKB:Q99JX3, ECO:0000269|PubMed:10487747, ECO:0000269|PubMed:11101516, ECO:0000269|PubMed:21515684, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:22523075, ECO:0000269|PubMed:27062250, ECO:0000269|PubMed:28067262}.FUNCTION: Probable actin-based motor with a protein kinase activity. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments. {ECO:0000250|UniProtKB:Q1EG27}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for GORASP2-MYO3B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GORASP2-MYO3B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GORASP2-MYO3B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GORASP2-MYO3B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource