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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GPATCH8-NPLOC4 (FusionGDB2 ID:34124)

Fusion Gene Summary for GPATCH8-NPLOC4

Fusion gene summary

Fusion gene information	Fusion gene name: GPATCH8-NPLOC4
	Fusion gene ID: 34124
		Hgene	Tgene
	Gene symbol	GPATCH8	NPLOC4
	Gene ID	23131	55666
	Gene name	G-patch domain containing 8	NPL4 homolog, ubiquitin recognition factor
	Synonyms	GPATC8\|KIAA0553	NPL4
	Cytomap	17q21.31	17q25.3
	Type of gene	protein-coding	protein-coding
	Description	G patch domain-containing protein 8	nuclear protein localization protein 4 homologNPLOC4 ubiquitin recognition factornuclear protein localization 4 homolog
	Modification date	20200320	20200313
	UniProtAcc	Q9UKJ3	Q8TAT6
	Ensembl transtripts involved in fusion gene	ENST00000434000, ENST00000591680, ENST00000586265, ENST00000588554, ENST00000592154,	ENST00000539314, ENST00000572760, ENST00000573876, ENST00000574344, ENST00000331134, ENST00000374747,
Fusion gene scores	* DoF score	22 X 14 X 12=3696	15 X 9 X 10=1350
	# samples	27	18
	** MAII score	log2(27/3696*10)=-3.77493344436523 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(18/1350*10)=-2.90689059560852 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GPATCH8 [Title/Abstract] AND NPLOC4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GPATCH8(42512433)-NPLOC4(79596831), # samples:3
Anticipated loss of major functional domain due to fusion event.	GPATCH8-NPLOC4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. GPATCH8-NPLOC4 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across GPATCH8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NPLOC4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A8-A07B-01A	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-

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Fusion Gene ORF analysis for GPATCH8-NPLOC4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000434000	ENST00000539314	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-
5CDS-5UTR	ENST00000591680	ENST00000539314	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-
5CDS-intron	ENST00000434000	ENST00000572760	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-
5CDS-intron	ENST00000434000	ENST00000573876	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-
5CDS-intron	ENST00000434000	ENST00000574344	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-
5CDS-intron	ENST00000591680	ENST00000572760	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-
5CDS-intron	ENST00000591680	ENST00000573876	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-
5CDS-intron	ENST00000591680	ENST00000574344	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-
5UTR-3CDS	ENST00000586265	ENST00000331134	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-
5UTR-3CDS	ENST00000586265	ENST00000374747	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-
5UTR-5UTR	ENST00000586265	ENST00000539314	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-
5UTR-intron	ENST00000586265	ENST00000572760	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-
5UTR-intron	ENST00000586265	ENST00000573876	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-
5UTR-intron	ENST00000586265	ENST00000574344	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-
Frame-shift	ENST00000434000	ENST00000331134	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-
Frame-shift	ENST00000434000	ENST00000374747	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-
In-frame	ENST00000591680	ENST00000331134	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-
In-frame	ENST00000591680	ENST00000374747	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-
intron-3CDS	ENST00000588554	ENST00000331134	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-
intron-3CDS	ENST00000588554	ENST00000374747	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-
intron-3CDS	ENST00000592154	ENST00000331134	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-
intron-3CDS	ENST00000592154	ENST00000374747	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-
intron-5UTR	ENST00000588554	ENST00000539314	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-
intron-5UTR	ENST00000592154	ENST00000539314	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-
intron-intron	ENST00000588554	ENST00000572760	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-
intron-intron	ENST00000588554	ENST00000573876	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-
intron-intron	ENST00000588554	ENST00000574344	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-
intron-intron	ENST00000592154	ENST00000572760	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-
intron-intron	ENST00000592154	ENST00000573876	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-
intron-intron	ENST00000592154	ENST00000574344	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000591680	GPATCH8	chr17	42512433	-	ENST00000331134	NPLOC4	chr17	79596831	-	4563	379	31	2190	719
ENST00000591680	GPATCH8	chr17	42512433	-	ENST00000374747	NPLOC4	chr17	79596831	-	5772	379	31	2217	728

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000591680	ENST00000331134	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-	0.001668645	0.99833137
ENST00000591680	ENST00000374747	GPATCH8	chr17	42512433	-	NPLOC4	chr17	79596831	-	0.000896337	0.9991036

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Fusion Genomic Features for GPATCH8-NPLOC4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GPATCH8-NPLOC4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:42512433/chr17:79596831)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GPATCH8 Q9UKJ3	NPLOC4 Q8TAT6
	FUNCTION: The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729). {ECO:0000250\|UniProtKB:Q9ES54, ECO:0000269\|PubMed:26471729}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GPATCH8

chr17:42512433

chr17:79596831

ENST00000591680

40_86

116

1503.0

Domain

G-patch

Tgene

NPLOC4

chr17:42512433

chr17:79596831

ENST00000331134

226_363

609.0

Domain

MPN

Tgene

NPLOC4

chr17:42512433

chr17:79596831

ENST00000374747

226_363

618.0

Domain

MPN

Tgene

NPLOC4

chr17:42512433

chr17:79596831

ENST00000331134

580_608

609.0

Zinc finger

RanBP2-type

Tgene

NPLOC4

chr17:42512433

chr17:79596831

ENST00000374747

580_608

618.0

Zinc finger

RanBP2-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GPATCH8

chr17:42512433

chr17:79596831

ENST00000434000

89_124

1425.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

GPATCH8

chr17:42512433

chr17:79596831

ENST00000591680

89_124

116

1503.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

GPATCH8

chr17:42512433

chr17:79596831

ENST00000434000

1384_1390

1425.0

Compositional bias

Note=Poly-Ala

Hgene

GPATCH8

chr17:42512433

chr17:79596831

ENST00000434000

1472_1478

1425.0

Compositional bias

Note=Poly-Ala

Hgene

GPATCH8

chr17:42512433

chr17:79596831

ENST00000434000

665_720

1425.0

Compositional bias

Note=Lys-rich

Hgene

GPATCH8

chr17:42512433

chr17:79596831

ENST00000434000

745_749

1425.0

Compositional bias

Note=Poly-Arg

Hgene

GPATCH8

chr17:42512433

chr17:79596831

ENST00000434000

772_775

1425.0

Compositional bias

Note=Poly-Gly

Hgene

GPATCH8

chr17:42512433

chr17:79596831

ENST00000434000

804_1009

1425.0

Compositional bias

Note=Ser-rich

Hgene

GPATCH8

chr17:42512433

chr17:79596831

ENST00000591680

1384_1390

116

1503.0

Compositional bias

Note=Poly-Ala

Hgene

GPATCH8

chr17:42512433

chr17:79596831

ENST00000591680

1472_1478

116

1503.0

Compositional bias

Note=Poly-Ala

Hgene

GPATCH8

chr17:42512433

chr17:79596831

ENST00000591680

665_720

116

1503.0

Compositional bias

Note=Lys-rich

Hgene

GPATCH8

chr17:42512433

chr17:79596831

ENST00000591680

745_749

116

1503.0

Compositional bias

Note=Poly-Arg

Hgene

GPATCH8

chr17:42512433

chr17:79596831

ENST00000591680

772_775

116

1503.0

Compositional bias

Note=Poly-Gly

Hgene

GPATCH8

chr17:42512433

chr17:79596831

ENST00000591680

804_1009

116

1503.0

Compositional bias

Note=Ser-rich

Hgene

GPATCH8

chr17:42512433

chr17:79596831

ENST00000434000

40_86

1425.0

Domain

G-patch

Hgene

GPATCH8

chr17:42512433

chr17:79596831

ENST00000434000

136_160

1425.0

Zinc finger

C2H2-type

Hgene

GPATCH8

chr17:42512433

chr17:79596831

ENST00000591680

136_160

116

1503.0

Zinc finger

C2H2-type

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Fusion Gene Sequence for GPATCH8-NPLOC4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>34124_34124_1_GPATCH8-NPLOC4_GPATCH8_chr17_42512433_ENST00000591680_NPLOC4_chr17_79596831_ENST00000331134_length(transcript)=4563nt_BP=379nt
GCGTCGTCCTGAGAGGAGTGAAGGCGGCAAAATGGCGGACCGCTTCTCCCGCTTCAACGAAGACCGAGACTTTCAGGGTAATCACTTTGA
TCAGTATGAGGAAGGACACTTGGAAATTGAACAAGCGTCACTTGACAAGCCTATAGAATCGGATAATATTGGACACCGCTTACTCCAGAA
ACATGGGTGGAAGCTGGGCCAGGGATTGGGAAAATCTCTTCAGGGGAGAACAGATCCCATTCCAATCGTTGTCAAGTATGATGTCATGGG
CATGGGTCGCATGGAAATGGAGCTTGATTATGCTGAAGATGCTACCGAACGGCGCCGTGTCCTAGAAGTAGAAAAAGAAGACACAGAAGA
GCTGAGACAAAAGTACAAGATAATTCGTGTCCAGTCCCCGGATGGAGTGAAGCGGATCACAGCAACAAAGAGAGAAACAGCAGCAACATT
TTTGAAAAAGGTTGCAAAGGAGTTTGGCTTCCAAAATAATGGCTTCTCGGTTTACATCAATAGAAACAAGACCGGAGAGATAACAGCCTC
CTCCAACAAATCCCTCAACTTGCTAAAAATCAAGCATGGCGATTTGTTGTTCCTGTTTCCCTCGAGCCTTGCTGGGCCCTCATCTGAAAT
GGAGACGTCAGTTCCACCGGGCTTCAAAGTCTTTGGCGCTCCCAACGTGGTGGAGGATGAGATTGATCAGTACCTCAGCAAACAGGACGG
GAAGATTTACAGAAGCCGAGACCCACAGCTATGCCGCCACGGCCCTTTGGGGAAATGCGTGCACTGCGTCCCTCTAGAGCCATTCGATGA
GGACTATCTAAACCATCTCGAGCCTCCCGTGAAGCACATGTCCTTCCACGCCTACATCCGGAAGCTGACTGGAGGGGCTGACAAGGGGAA
GTTTGTTGCCCTGGAGAACATCAGCTGCAAGATTAAGTCAGGGTGCGAGGGGCACCTCCCGTGGCCGAATGGCATCTGTACTAAGTGCCA
GCCGAGCGCCATCACGCTGAACAGACAGAAGTACAGGCATGTGGACAATATCATGTTTGAGAATCACACCGTCGCTGACCGCTTTCTTGA
CTTCTGGAGAAAGACAGGGAACCAGCATTTTGGGTACTTATACGGACGGTACACGGAGCACAAAGACATTCCCCTTGGCATCAGGGCTGA
AGTGGCTGCGATTTATGAGCCACCTCAGATTGGTACACAGAACAGCTTGGAGCTTCTTGAGGATCCAAAAGCTGAAGTGGTCGATGAAAT
TGCTGCCAAACTTGGCCTGCGGAAGGTTGGCTGGATATTTACAGACCTCGTCTCAGAAGATACCCGAAAGGGTACCGTCCGCTACAGTCG
AAATAAGGACACCTATTTCCTAAGTTCAGAAGAGTGCATCACTGCAGGAGACTTCCAGAACAAGCATCCCAACATGTGCCGGCTCTCTCC
AGACGGACATTTTGGATCCAAGTTTGTTACTGCAGTGGCTACAGGTGGTCCTGACAACCAAGTCCACTTTGAAGGGTACCAGGTGTCCAA
TCAGTGTATGGCACTGGTCCGTGATGAGTGTTTGCTGCCATGCAAGGACGCCCCGGAGCTTGGCTACGCCAAGGAGTCTAGCAGTGAGCA
GTACGTGCCTGATGTGTTTTATAAGGACGTAGACAAGTTTGGCAACGAGATCACCCAGCTGGCCCGGCCCCTGCCTGTGGAGTATCTCAT
CATAGACATCACAACAACTTTCCCCAAGGATCCAGTTTACACTTTTTCTATTTCGCAAAATCCATTTCCTATTGAAAACCGGGATGTATT
GGGTGAGACACAGGACTTCCATAGCTTGGCCACCTATTTGTCTCAGAATACCTCATCTGTGTTCTTGGATACCATCTCAGATTTCCACCT
CTTGCTGTTCCTGGTCACCAATGAAGTTATGCCTCTGCAGGACAGCATCAGCTTGCTGCTGGAGGCCGTGCGGACCAGAAATGAGGAGCT
CGCCCAGACATGGAAGAGGTCTGAGCAGTGGGCCACCATCGAGCAGCTGTGCAGCACAGTTGGCGGGCAGCTCCCAGGTCTCCATGAGTA
CGGCGCCGTCGGGGGCTCCACACACACGGCCACTGCAGCCATGTGGGCCTGTCAGCACTGCACGTTCATGAACCAGCCAGGCACAGGCCA
CTGCGAGATGTGCAGCCTCCCCAGGACCTAGGGCGCCTGCCCTCTGCTGGCTAGGACCGGGCCCAGCCCAGCCCTTCCTGAAGCCAGAAG
CGTTGCTGAGTGTGTTCCCTGTAACTGCCCCATAGTGGGCAGCCCTGGAGGAACAAGGGGCTGGCTGTCCTGGGCTCCCTGACCCACTGA
AGCTTCTCAGCACGTTCCTCCCTGGAGAGCGGGCGCCACGGCTGGTATTCTGCAGGCTGAATGCAGTCTCCAGACTGGAAACGCAGAGCG
GCTCCTCACGCCTAATCCTGTTGACAAGTCCCCCGCCGTGTTGGAAAGACCTCTCGCCTCTACGTGGCACCTGGAATTGGGGCGCACAGG
GAGGGGCCGATGCTGCCACCACCCAGCCTTCTCTTTATTTTCAGTGCTTTTTGTTTGGCCTCCCTGCCCCCATGTTTTTCTGGCTGGGAG
CTCTTGGTTACCCCCTTGTCTGACTGCTTGGTGGCAGGCACCCTGCCTGTGAGGGCCACTTTCCTCTTCTAGTAGCTGTTGTCTGGTGGG
GACGCAGTGGCCCTGGACACGGCTCCCCTCTGCAGGTCTGCAGGTCGGTTTGCTGCCTGCCCTCCTCCTCTCACCCGATGTCCAGGTGGG
ATTTTAAAGTCTGCATTGGTTATAATAACAGTTATCAGTAATTCCTGCCCAGAAGACTTTTATTTATTTTTTTTTAAGATAAAAACTGCA
CAAAAGGGGAGTGAGAGAGACTAGTTTCCACATCCTTCCCTCCTTTAGTGAAGCCCCCGAGGTTGTGTCCAGGGTGATGAGTGTGGACGG
GGGCACCAGTCAGTTCTCCCTTGAAGTAAACCTCAGTGCCTGAGACTTTTCTACCAAGCCACACAGCTGCAGCAACTGCAGATACTGCGG
GCTGAGCAGGAGCAGTGGTGGCGCCTGCCCTGAGGCTGCCCTGCGATGGCCTGGGTGGGAGAGCTGGGTCACCGGTGCCGATGCTCTGGC
CCTCCCCAATACGCTGCTTCGTCCCACTGCACCGCCTGGCTGAGGGCGTTAGGGGCTGTGCCTCTTGTGAGGGCCATTTGGGACCTCCCT
GGGGCACTGCACAATTGATAGTGTACCAATAGAGGGAGACTGGGCGATCTGGAACAGCACGTGGTGGGGTCCTGCTTGTGTGCTCTGCGT
TCCTCTGTGGCGTGGCCAGGCCGGGGCATGGCTCTTACCCGGGGAGTGGTGGGCATCTCGATGCTTCTTTGCCTTAATGATGGCCACATC
TGGGCTGCTCTGCACCCACGGGAGAGGCTGGCCCAGCTGCAGACTGCTTAGGGACTTCTGTGTCCATCCTGGGGGGTAAGCCCACGTGAC
CCACATTCTTGGCACTATGAACAGAGAACATTTGCCTGTTGGCTTCTGAAGTGGTCAGGGCCATGGCTGACACCTCCAGGTCCGCCTGGC
ATGGGACACCAAGTGGAAGGCCCAAGCAGCTCATCTGCTCTTGGGACCAGGGGCCAGTTGGGTTGGGTCTGGTCACGGCAGAGCTATTGT
GGAGGGTCAGGAAGGGTGGAGAGGAGCTGGGTTGAAGCGGACTGCTGCGGATGCAACTCCCAGCTTGCCCACCGCGGGCTGTCTGCTCTC
CCTCCTAGCAGCTGTCACACTGAAGTTTTGTCCTCTGCTGTCTCCTCTGGTCCTGAGATGAGCTGTGAGCCTAGGTGGCCAAGGCTTCCT
GCATTGCTTCCCTGTGAGTCCAAGGCCTTCCCCCACCACTGGGCAGAGGCTGGACAGCACGGACTTCTAGAGAGAGCCGCGTTGCCAGTT
CCTCTCCCACTCGCTCGTCCTTATCCACCACGCTATTATAGTTTCCGTTGTCCTCCACCAGCATTTCCCTTACTCTGAAGTTCCGGCATT
CACATCATTCATGTTTTCTTTTGTCTTTTAGCTAAAGGAAAAGCATTGGCGATTTGTCTGATTCTGGTTTTGAGTTACTCTTTGTTCAGT
AATGCACTTTATTTTATTGTCCAAAGAGAGTCAGAGCTAAGCATACAGGCTTGGGGGTGAGCCCTGCTGTGAGAGTTCAGGCCCTGGGAG
GCTCAGCCACCTCCTCTTGTGGGAAGGAGGTCTCAGCCCCACCTCGCATCTTCACCTGCCCTTGGTGTGGACACACCCTCTCATGCTACC
AGCACCATAATCCAGTGGGGGTGACTGGGTGCACACCTGCCCAGGTGAACACAGCGGCTGCCAGTCTCCTGGTCCCGAGAGGAGGTGGGG
CCTGGCCCTGGCTCCCTCCAACCAGCTGCTCCTGGGACACAGGTGCTCCTGCTTCGGCTCTGTTTCGGCTCACAGGTGTGCATCACTGGG

>34124_34124_1_GPATCH8-NPLOC4_GPATCH8_chr17_42512433_ENST00000591680_NPLOC4_chr17_79596831_ENST00000331134_length(amino acids)=719AA_BP=116
MADRFSRFNEDRDFQGNHFDQYEEGHLEIEQASLDKPIESDNIGHRLLQKHGWKLGQGLGKSLQGRTDPIPIVVKYDVMGMGRMEMELDY
AEDATERRRVLEVEKEDTEELRQKYKIIRVQSPDGVKRITATKRETAATFLKKVAKEFGFQNNGFSVYINRNKTGEITASSNKSLNLLKI
KHGDLLFLFPSSLAGPSSEMETSVPPGFKVFGAPNVVEDEIDQYLSKQDGKIYRSRDPQLCRHGPLGKCVHCVPLEPFDEDYLNHLEPPV
KHMSFHAYIRKLTGGADKGKFVALENISCKIKSGCEGHLPWPNGICTKCQPSAITLNRQKYRHVDNIMFENHTVADRFLDFWRKTGNQHF
GYLYGRYTEHKDIPLGIRAEVAAIYEPPQIGTQNSLELLEDPKAEVVDEIAAKLGLRKVGWIFTDLVSEDTRKGTVRYSRNKDTYFLSSE
ECITAGDFQNKHPNMCRLSPDGHFGSKFVTAVATGGPDNQVHFEGYQVSNQCMALVRDECLLPCKDAPELGYAKESSSEQYVPDVFYKDV
DKFGNEITQLARPLPVEYLIIDITTTFPKDPVYTFSISQNPFPIENRDVLGETQDFHSLATYLSQNTSSVFLDTISDFHLLLFLVTNEVM

--------------------------------------------------------------
>34124_34124_2_GPATCH8-NPLOC4_GPATCH8_chr17_42512433_ENST00000591680_NPLOC4_chr17_79596831_ENST00000374747_length(transcript)=5772nt_BP=379nt
GCGTCGTCCTGAGAGGAGTGAAGGCGGCAAAATGGCGGACCGCTTCTCCCGCTTCAACGAAGACCGAGACTTTCAGGGTAATCACTTTGA
TCAGTATGAGGAAGGACACTTGGAAATTGAACAAGCGTCACTTGACAAGCCTATAGAATCGGATAATATTGGACACCGCTTACTCCAGAA
ACATGGGTGGAAGCTGGGCCAGGGATTGGGAAAATCTCTTCAGGGGAGAACAGATCCCATTCCAATCGTTGTCAAGTATGATGTCATGGG
CATGGGTCGCATGGAAATGGAGCTTGATTATGCTGAAGATGCTACCGAACGGCGCCGTGTCCTAGAAGTAGAAAAAGAAGACACAGAAGA
GCTGAGACAAAAGTACAAGATAATTCGTGTCCAGTCCCCGGATGGAGTGAAGCGGATCACAGCAACAAAGAGAGAAACAGCAGCAACATT
TTTGAAAAAGGTTGCAAAGGAGTTTGGCTTCCAAAATAATGGCTTCTCGGTTTACATCAATAGAAACAAGACCGGAGAGATAACAGCCTC
CTCCAACAAATCCCTCAACTTGCTAAAAATCAAGCATGGCGATTTGTTGTTCCTGTTTCCCTCGAGCCTTGCTGGGCCCTCATCTGAAAT
GGAGACGTCAGTTCCACCGGGCTTCAAAGTCTTTGGCGCTCCCAACGTGGTGGAGGATGAGATTGATCAGTACCTCAGCAAACAGGACGG
GAAGATTTACAGAAGCCGAGACCCACAGCTATGCCGCCACGGCCCTTTGGGGAAATGCGTGCACTGCGTCCCTCTAGAGCCATTCGATGA
GGACTATCTAAACCATCTCGAGCCTCCCGTGAAGCACATGTCCTTCCACGCCTACATCCGGAAGCTGACTGGAGGGGCTGACAAGGGGAA
GTTTGTTGCCCTGGAGAACATCAGCTGCAAGATTAAGTCAGGGTGCGAGGGGCACCTCCCGTGGCCGAATGGCATCTGTACTAAGTGCCA
GCCGAGCGCCATCACGCTGAACAGACAGAAGTACAGGCATGTGGACAATATCATGTTTGAGAATCACACCGTCGCTGACCGCTTTCTTGA
CTTCTGGAGAAAGACAGGGAACCAGCATTTTGGGTACTTATACGGACGGTACACGGAGCACAAAGACATTCCCCTTGGCATCAGGGCTGA
AGTGGCTGCGATTTATGAGCCACCTCAGATTGGTACACAGAACAGCTTGGAGCTTCTTGAGGATCCAAAAGCTGAAGTGGTCGATGAAAT
TGCTGCCAAACTTGGCCTGCGGAAGGTTGGCTGGATATTTACAGACCTCGTCTCAGAAGATACCCGAAAGGGTACCGTCCGCTACAGTCG
AAATAAGGACACCTATTTCCTAAGTTCAGAAGAGTGCATCACTGCAGGAGACTTCCAGAACAAGCATCCCAACATGTGCCGGCTCTCTCC
AGACGGACATTTTGGATCCAAGTTTGTTACTGCAGTGGCTACAGGTGGTCCTGACAACCAAGTCCACTTTGAAGGGTACCAGGTGTCCAA
TCAGTGTATGGCACTGGTCCGTGATGAGTGTTTGCTGCCATGCAAGGACGCCCCGGAGCTTGGCTACGCCAAGGAGTCTAGCAGTGAGCA
GTACGTGCCTGATGTGTTTTATAAGGACGTAGACAAGTTTGGCAACGAGATCACCCAGCTGGCCCGGCCCCTGCCTGTGGAGTATCTCAT
CATAGACATCACAACAACTTTCCCCAAGGATCCAGTTTACACTTTTTCTATTTCGCAAAATCCATTTCCTATTGAAAACCGGGATGTATT
GGGTGAGACACAGGACTTCCATAGCTTGGCCACCTATTTGTCTCAGAATACCTCATCTGTGTTCTTGGATACCATCTCAGATTTCCACCT
CTTGCTGTTCCTGGTCACCAATGAAGTTATGCCTCTGCAGGACAGCATCAGCTTGCTGCTGGAGGCCGTGCGGACCAGAAATGAGGAGCT
CGCCCAGACATGGAAGAGGTCTGAGCAGTGGGCCACCATCGAGCAGCTGTGCAGTGAGTACCCCCACCCCCTGCCCCGGCACCCCGTGGC
TGGGGCCGGAGAGCAGCCCACTCTGCACAGCTCCCCACTGCCGGTGGTGCCCTGGATTCCGCACCCAGCTGCATCCTGGCAGGTGCCATC
GGCAATGCAACGAGTAGAGACTCGGCCTCCCTGCCAGGCACGTGGCAGGCTCCGGTGATGGAGCAGACATGTTGTCCAGGCCGTACGTCT
TAGGTACACAGCCCTGTAAATTTTATAAACCTGTACATCAGAGATACTAATCTCCAGGCATCCTAGGAGCACTTTGAACATCATTGTCTT
AAGAGAATCAGAAACTTTATGGAAGCGCCGGAAGCGTGGGACCTTTTGGTCTCCTTGAGAATTTCCCTTTAGTGCTTAAAGCTGTAAGGA
GGAGAAGCCTGCAGCATCCATGTTGTTGCTGGTGGACACTACGGAACGGACCGCAGGCATTGCGTGTCTTCCGGACCCTCAGTCACCAGG
TCCTGAACGATTCCCCACTCGTGAGAACCTTCTGTCAGCATTGCTGCAGGGACTCCTCACGCACCGTGGTGCCTCGTGCAGCCCGAGTGC
CCTGAGTCCCTGCAGCTGAGAGCACCAGAGTGCCCGGGAGCTACGGCCCTGGACAAATGCTAGAATCCTTCTGTTAACACAGCCTTCAAA
AGACACATCAAACACCTTTATACCATTTCCTGTTTTTTTTTTTTTTTTTGAGACGGAGTTTGGCTCTTGTCACCCAGGCTGGAGTGTGGT
GGCGTGATCTTGCCTCACTGCAACCTCCACCTCCTGGGTTCAAACGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCATG
TGCCACCATGCCTGGATAATTTTTGTATTCTTAGTAGAGCCAGGGTTTCACCATGTTAGCCAGGCTGGTCTCGAACTCCTGACCTTGTGA
TCTGCTTGCCTCTGCCTCCCAGAGTGTTGGGATTACAGGTGTGAGCCACCACGCCCAGCCGAGGTTTTCTTTTCACACAATTCTTTGTTT
ATTATTTTTATTTTTGTAGAGACAGGGTCTCACTCTATTGCCGAGGCTGGAGTGCAGTTGCACAATCGTAACTCACTGCAGCCTCAAACT
CCAGGCTCAAGTGATCTTTCTGCTTCAGCCTGCTGAGTAACTGGGACCACAGGCTTGCAACACCACACCCAGCTAATTCTTGGGGCTTTG
TTGTTGCTTTTTATTTGTTTGTTTTTTAAAAATAATTTTAACTTATTTTAGATTCACAGGGTACATGTGCAGGTTTGTCACCTGGGTATA
TTGCCTGATGCTGAGGTTGGGGTATGATTGATCACATCACCCAGGTACTACACATAGTACCTAATAGTTTTTCAGCCCGCCCTGCTCTTT
GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTTTGAGCTGGAGCCTCACCCTGTCTCCCAGGCTGGAGTGCAGTGGCGCAATCTTAG
CTCACTGCAAACTCTGCCTCCTGGGTTGAAGCAATTCCCCTCCCTCAGCCTCCCGAGTAGCTGGGATTACAGATGTGTACCACCACACCT
GGCGTTGCCATCTTTATGTACGTGAGTACCCATGTTTAGCTCCCACTTATAAATGAAAACATGTAGTATTTGGTTTGCTGTTCCTGCATT
AGTTTGCTTAGAATAATGGCCTTCAACTGCATCCATGTTGCTGCAAAGGACATGATTTCATTCCTTTTTATGGCTGCAAAATTTTTTAAT
ATTTTTGTATCAATGAGGTCTCACTGTGTTGCCCAGACTGGTCTCAAACTTTGGCCTCAAGCATTCCTTGCACCTCAGCCTCACAAAGTC
CTGAGATTATACCTGGGAGCCACTGCACCCAGCCCTTTGATGCAGTTCTAACAATGACACCAGTCTTTTTTTTTTTTTTCTTTTTTGTTT
CCCTTTTAGAGACAGGGTTTCACTCTGTTGCCTAGGCTGGAGTGCAGTGGAGTGATCATAGCTCACTACAGCCTTCAATTCCTGAGCTCA
AGCGATCCTCCTGCATCAGCTTTCGGAGTACCTAGGAGTATAAACATGAGCCACTACACCCAACTAATGTTTTTGGTTGGTGTTTTTTTT
TTTTCTTTAAGAGATAGGGTTGGCCGGGCCCGGTGGCTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGTGGATCACA
ACGTCAAGGGATTGAGACCATCCTGGCCAACATGGTGAAACCCCATTTCTGTTAAAACTACAAAAATTAGCTGGGCATGGTGGCGAGCGC
CTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGACCCAGGAAGCGTAGGTTGTAGTGAGCTGAGATCGTGCCACTGTA
CTCCAGCCTGGGCGACAGAGCAAGACTCTGTCTCAAAAAAAAAAAAAAGATGTGGTCTTGCCATGTTGCCCAGGCTGGTCTCAAACTCCT
AGGCTCAAGTGATCTTCCTGCCTTGGTTCCCAAAGTGCTGAGATTACAGCTGTGAGCCACTGCACCTGACCTTTTTTTTTTCCCCCCTCC
TTTTTTTTTTGAGACAGGTTCTCACTCTGTCACCCAGGCTGAAGTGCAGTGGCATTTGAGGTCAGTCTCACCTTGACCTCCCCAGGCTCA
AACAATCCTCCCGCCTCAGCCTCCTGAGCAGCTGGGACTACAAGCATGTGCCACCATCCCTGGCTGATTTTTTAAATTTGTTGTAGAGAT
GAGGTCTCACTATGTTGCCCAGGCTGGTCTTGAACTCTTGGGCCCAAGCGATCCTCCCGCCTCAGTGCTGAGATTGCAGTGGTAAGCCAC
CATGTCCAGCCAACTCTTTAATAATAGGCAGTTCTGACTGGTGTAAGTTCTGACTGGTATCTCACTGTGGTTTTAATTTGCATCTCTGAT
GATTAGTGATGTTGGGCATTTTTTCATGGGTTTTTTGTTTGTTTGTTTTGAGACAAAGTCTTGTTCTGTTGCCCAGGCTGGAGTGCAGTA
GTGTGATCTCAGCTCACTGCAGCCTCCACCTCCCGGGTTCAAGCCATTGTCCAGCCTCTGCCTCCTAAGTAGCTGGAATTACAGGTGGCT
GCCACCACACCCAGCTAATTTTTTTAGTTTTAGTAGAGACAGGGTTTCTCCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGTG
ATCCACCCACCTCGGCTTCCCAAAGTGCTGGGATTATAGGTGTGAGCCACCGCGCCCGGCCCTCATGGGTTGTTTTGTTTTGTTTTGAGA
CGGAATCTCACCCTGTCACCCAGGCTGCAGTGCAATCTCATGATCTCCACTTACTGCAACCTCCACGTCCTGGGTTCAAGTGATACTCCT
GCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGTGCACCCACGCCTGGCTAATTTTTATATTTTTAGTAGAGATGGGGTTTCACCATGT
TGGTCAGGCTGGTCTGGAACTCCTGACCTCAGGTGATCCACCTGCCTCGGTCTCCCAAAGTGCTGGGATTACAGACGTGTATACACAAGA
CACAAAGATCAGCTCAGGATGGGTCATAGGCCTAATGGTAAAAGGTAAAACTATGAAGCAGGCTGGGCATGATGTCTCATAGCTATAATC
CTAACACTCTAGGAGGCCAAAGCTGGAGGACACTGTAGCCCAGAAGTGTGAGACCAGCCCACACAGCATAGTGAAGCCCCGTCTGTACAA

>34124_34124_2_GPATCH8-NPLOC4_GPATCH8_chr17_42512433_ENST00000591680_NPLOC4_chr17_79596831_ENST00000374747_length(amino acids)=728AA_BP=116
MADRFSRFNEDRDFQGNHFDQYEEGHLEIEQASLDKPIESDNIGHRLLQKHGWKLGQGLGKSLQGRTDPIPIVVKYDVMGMGRMEMELDY
AEDATERRRVLEVEKEDTEELRQKYKIIRVQSPDGVKRITATKRETAATFLKKVAKEFGFQNNGFSVYINRNKTGEITASSNKSLNLLKI
KHGDLLFLFPSSLAGPSSEMETSVPPGFKVFGAPNVVEDEIDQYLSKQDGKIYRSRDPQLCRHGPLGKCVHCVPLEPFDEDYLNHLEPPV
KHMSFHAYIRKLTGGADKGKFVALENISCKIKSGCEGHLPWPNGICTKCQPSAITLNRQKYRHVDNIMFENHTVADRFLDFWRKTGNQHF
GYLYGRYTEHKDIPLGIRAEVAAIYEPPQIGTQNSLELLEDPKAEVVDEIAAKLGLRKVGWIFTDLVSEDTRKGTVRYSRNKDTYFLSSE
ECITAGDFQNKHPNMCRLSPDGHFGSKFVTAVATGGPDNQVHFEGYQVSNQCMALVRDECLLPCKDAPELGYAKESSSEQYVPDVFYKDV
DKFGNEITQLARPLPVEYLIIDITTTFPKDPVYTFSISQNPFPIENRDVLGETQDFHSLATYLSQNTSSVFLDTISDFHLLLFLVTNEVM
PLQDSISLLLEAVRTRNEELAQTWKRSEQWATIEQLCSEYPHPLPRHPVAGAGEQPTLHSSPLPVVPWIPHPAASWQVPSAMQRVETRPP

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Fusion Gene PPI Analysis for GPATCH8-NPLOC4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GPATCH8-NPLOC4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for GPATCH8-NPLOC4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source