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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GPI-COG4 (FusionGDB2 ID:34281)

Fusion Gene Summary for GPI-COG4

check button Fusion gene summary
Fusion gene informationFusion gene name: GPI-COG4
Fusion gene ID: 34281
HgeneTgene
Gene symbol

GPI

COG4

Gene ID

10007

25839

Gene nameglucosamine-6-phosphate deaminase 1component of oligomeric golgi complex 4
SynonymsGNP1|GNPDA|GNPI|GPI|HLNCDG2J|COD1|SWILS
Cytomap

5q31.3

16q22.1

Type of geneprotein-codingprotein-coding
Descriptionglucosamine-6-phosphate isomerase 1GNPDA 1glcN6P deaminase 1oscillinconserved oligomeric Golgi complex subunit 4COG complex subunit 4complexed with Dor1pconserved oligomeric Golgi complex protein 4
Modification date2020031320200320
UniProtAcc

PIGT

Q9H9E3

Ensembl transtripts involved in fusion geneENST00000356487, ENST00000415930, 
ENST00000586425, 		ENST00000323786, 
ENST00000393612, ENST00000564653, 
Fusion gene scores* DoF score27 X 23 X 11=683112 X 11 X 12=1584
# samples 2823
** MAII scorelog2(28/6831*10)=-4.60859805991281
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/1584*10)=-2.78386656913523
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GPI [Title/Abstract] AND COG4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGPI(34859607)-COG4(70553634), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across GPI (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across COG4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-34-2596GPIchr19

34859607

+COG4chr16

70553634

-


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Fusion Gene ORF analysis for GPI-COG4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000356487ENST00000323786GPIchr19

34859607

+COG4chr16

70553634

-
In-frameENST00000356487ENST00000393612GPIchr19

34859607

+COG4chr16

70553634

-
In-frameENST00000356487ENST00000564653GPIchr19

34859607

+COG4chr16

70553634

-
In-frameENST00000415930ENST00000323786GPIchr19

34859607

+COG4chr16

70553634

-
In-frameENST00000415930ENST00000393612GPIchr19

34859607

+COG4chr16

70553634

-
In-frameENST00000415930ENST00000564653GPIchr19

34859607

+COG4chr16

70553634

-
In-frameENST00000586425ENST00000323786GPIchr19

34859607

+COG4chr16

70553634

-
In-frameENST00000586425ENST00000393612GPIchr19

34859607

+COG4chr16

70553634

-
In-frameENST00000586425ENST00000564653GPIchr19

34859607

+COG4chr16

70553634

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000415930GPIchr1934859607+ENST00000323786COG4chr1670553634-33296891702887905
ENST00000415930GPIchr1934859607+ENST00000393612COG4chr1670553634-15446891701543458
ENST00000415930GPIchr1934859607+ENST00000564653COG4chr1670553634-11016891701099309
ENST00000356487GPIchr1934859607+ENST00000323786COG4chr1670553634-32836431722841889
ENST00000356487GPIchr1934859607+ENST00000393612COG4chr1670553634-14986431721497442
ENST00000356487GPIchr1934859607+ENST00000564653COG4chr1670553634-10556431721053294
ENST00000586425GPIchr1934859607+ENST00000323786COG4chr1670553634-3067427252625866
ENST00000586425GPIchr1934859607+ENST00000393612COG4chr1670553634-1282427251281419
ENST00000586425GPIchr1934859607+ENST00000564653COG4chr1670553634-83942725837271

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000415930ENST00000323786GPIchr1934859607+COG4chr1670553634-0.0051848530.9948152
ENST00000415930ENST00000393612GPIchr1934859607+COG4chr1670553634-0.0031672470.9968328
ENST00000415930ENST00000564653GPIchr1934859607+COG4chr1670553634-0.0048751540.9951249
ENST00000356487ENST00000323786GPIchr1934859607+COG4chr1670553634-0.0050895850.9949104
ENST00000356487ENST00000393612GPIchr1934859607+COG4chr1670553634-0.0029493910.99705064
ENST00000356487ENST00000564653GPIchr1934859607+COG4chr1670553634-0.0045243180.9954757
ENST00000586425ENST00000323786GPIchr1934859607+COG4chr1670553634-0.0051950040.99480504
ENST00000586425ENST00000393612GPIchr1934859607+COG4chr1670553634-0.0025057530.9974942
ENST00000586425ENST00000564653GPIchr1934859607+COG4chr1670553634-0.0046109880.995389

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Fusion Genomic Features for GPI-COG4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GPI-COG4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:34859607/chr16:70553634)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPI

PIGT

COG4

Q9H9E3

578FUNCTION: Required for normal Golgi function (PubMed:19536132, PubMed:30290151). Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1 (PubMed:19536132). {ECO:0000269|PubMed:19536132, ECO:0000269|PubMed:30290151}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGPIchr19:34859607chr16:70553634ENST00000415930+518159_160173570.0RegionGlucose-6-phosphate binding
TgeneCOG4chr19:34859607chr16:70553634ENST0000039361208618_74053338.0RegionD domain
TgeneCOG4chr19:34859607chr16:70553634ENST0000039361208741_78553338.0RegionE domain%3B essential for proper cell surface glycosylation

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGPIchr19:34859607chr16:70553634ENST00000356487+418159_160134559.0RegionGlucose-6-phosphate binding
HgeneGPIchr19:34859607chr16:70553634ENST00000356487+418210_215134559.0RegionGlucose-6-phosphate binding
HgeneGPIchr19:34859607chr16:70553634ENST00000415930+518210_215173570.0RegionGlucose-6-phosphate binding


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Fusion Gene Sequence for GPI-COG4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>34281_34281_1_GPI-COG4_GPI_chr19_34859607_ENST00000356487_COG4_chr16_70553634_ENST00000323786_length(transcript)=3283nt_BP=643nt
AGAGAGGAGCTGAGGCCCCAGATCAGCGGCCGCGGGCAAGGTCGCTCAGCGGGCACCCGGCCTGGGTATCGGGGCGCGGGTCGGGGGCGG
GGCCGGGGCTCAGGGGTGGGGCCGGGCCGGGCCGGGCCGGGCGCCTGCGCCATAAAGGCCGCCGCGCGCCCACGCGCCTCGCTTGCTGCG
CGCTGCCGGCGCTCCTTCCTCCTCGGCTCGCGTCTCACTCAGTGTACCTTCTAGTCCCGCCATGGCCGCTCTCACCCGGGACCCCCAGTT
CCAGAAGCTGCAGCAATGGTACCGCGAGCACCGCTCCGAGCTGAACCTGCGCCGCCTCTTCGATGCCAACAAGGACCGCTTCAACCACTT
CAGCTTGACCCTCAACACCAACCATGGGCATATCCTGGTGGATTACTCCAAGAACCTGGTGACGGAGGACGTGATGCGGATGCTGGTGGA
CTTGGCCAAGTCCAGGGGCGTGGAGGCCGCCCGGGAGCGGATGTTCAATGGTGAGAAGATCAACTACACCGAGGGTCGAGCCGTGCTGCA
CGTGGCTCTGCGGAACCGGTCAAACACACCCATCCTGGTAGACGGCAAGGATGTGATGCCAGAGGTCAACAAGGTTCTGGACAAGATGAA
GTCTTTCTGCCAGAAAGTGGTGGAGAGAGAGCTGGATGCTCTTTTGGAACAGCAAAACACCATTGAAAGTAAGATGGTCACTCTCCACCG
AATGGGTCCTAATCTGCAGCTGATTGAGGGAGATGCAAAGCAGCTGGCTGGAATGATCACCTTTACCTGCAACCTGGCTGAGAATGTGTC
CAGCAAAGTTCGTCAGCTTGACCTGGCCAAGAACCGCCTCTATCAGGCCATTCAGAGAGCTGATGACATCTTGGACCTGAAGTTCTGCAT
GGATGGAGTTCAGACTGCTTTGAGGAGTGAAGATTATGAGCAGGCTGCAGCACATACTCATCGCTACTTGTGCCTGGACAAGTCGGTCAT
TGAGCTCAGCCGACAGGGCAAAGAGGGGAGCATGATTGATGCCAACCTGAAATTGCTGCAGGAAGCTGAGCAACGTCTCAAAGCCATTGT
GGCAGAGAAGTTTGCCATTGCCACCAAGGAAGGTGATCTGCCCCAGGTGGAGCGCTTCTTCAAGATCTTCCCACTGCTGGGTTTGCATGA
GGAGGGATTAAGAAAGTTCTCGGAGTACCTTTGCAAGCAGGTGGCCAGTAAAGCTGAGGAGAATCTGCTCATGGTGCTGGGGACAGACAT
GAGTGATCGGAGAGCTGCAGTCATCTTTGCAGATACACTTACTCTTCTGTTTGAAGGGATTGCCCGCATTGTGGAGACCCACCAGCCAAT
AGTGGAGACCTATTATGGGCCAGGGAGACTCTATACCCTGATCAAATATCTGCAGGTGGAATGTGACAGACAGGTGGAGAAGGTGGTAGA
CAAGTTCATCAAGCAAAGGGACTACCACCAGCAGTTCCGGCATGTTCAGAACAACCTGATGAGAAATTCTACAACAGAAAAAATCGAACC
AAGAGAACTGGACCCCATCCTGACTGAGGTCACCCTGATGAATGCCCGCAGTGAGCTATACTTACGCTTCCTCAAGAAGAGGATTAGCTC
TGATTTTGAGGTGGGAGACTCCATGGCCTCAGAGGAAGTAAAGCAAGAGCACCAGAAGTGTCTGGACAAACTCCTCAATAACTGCCTTTT
GAGCTGTACCATGCAGGAGCTAATTGGCTTATATGTTACCATGGAGGAGTACTTCATGAGGGAGACTGTCAATAAGGCTGTGGCTCTGGA
CACCTATGAGAAGGGCCAGCTGACATCCAGCATGGTGGATGATGTCTTCTACATTGTTAAGAAGTGCATTGGGCGGGCTCTGTCCAGCTC
CAGCATTGACTGTCTCTGTGCCATGATCAACCTCGCCACCACAGAGCTGGAGTCTGACTTCAGGGATGTTCTGTGTAATAAGCTGCGGAT
GGGCTTTCCTGCCACCACCTTCCAGGACATCCAGCGCGGGGTGACAAGTGCCGTGAACATCATGCACAGCAGCCTCCAGCAAGGCAAATT
TGACACAAAAGGCATCGAGAGTACTGACGAGGCGAAGATGTCCTTCCTGGTGACTCTGAACAACGTGGAAGTCTGCAGTGAAAACATCTC
CACTCTGAAGAAGACACTGGAGAGTGACTGCACCAAGCTCTTCAGCCAGGGCATTGGAGGGGAGCAGGCCCAGGCCAAGTTTGACAGCTG
CCTTTCTGACTTGGCCGCCGTGTCCAACAAATTCCGAGACCTCTTGCAGGAAGGGCTGACGGAGCTCAACAGCACAGCCATCAAGCCACA
GGTGCAGCCTTGGATCAACAGCTTTTTCTCCGTCTCCCACAACATCGAGGAGGAAGAATTCAATGACTATGAGGCCAACGACCCTTGGGT
ACAACAGTTCATCCTTAACCTGGAGCAGCAAATGGCAGAGTTCAAGGCCAGCCTGTCCCCGGTCATCTACGACAGCCTAACCGGCCTCAT
GACTAGCCTTGTTGCCGTCGAGTTGGAGAAAGTGGTGCTGAAATCCACCTTTAACCGGCTGGGTGGTCTGCAGTTTGACAAGGAGCTGAG
GTCGCTCATTGCCTACCTTACCACGGTGACCACCTGGACCATCCGAGACAAGTTTGCCCGGCTCTCCCAGATGGCCACCATCCTCAATCT
GGAGCGGGTGACCGAGATCCTCGATTACTGGGGACCCAATTCCGGCCCATTGACGTGGCGCCTCACCCCTGCTGAAGTGCGCCAGGTGCT
GGCCCTGCGGATAGACTTCCGCAGTGAAGATATCAAGAGGCTGCGCCTGTAGCTGCCTGGATGAGCACACCTGGCTCATCACACTTGCAG
GCCTGTTCCCTAAGGGGCCCCAGCCAAGGAGCTGAGCGAGGCTGTCTGGCTTGGGGGAGATCTGACAGCCCAGACCTTTCTACGGCTGGC
AGCAGAGAAACAAAGTCTGGACCCACTCCATGCTCTGCCCTCAGACCTGGCCAGGTGATGCTCTGGGGGCAGCATCTCCCCACCGAGAGA
AGCGGGCTCCTAATGAGGTGGGAAAGCCACGGCAGGCAGCGAGCAGCCCAGGCCAGCTTTCTGCATGGATGGTCAGTCTCTTGCCCTCAA
ACACTACAGCAAACAAGCTACCCCTGCCAGTCCTAGACAACTTGGGTACATCTGGGGACCTAGCAGTTAGGCTTGACTTTGAGGAGAGGC

>34281_34281_1_GPI-COG4_GPI_chr19_34859607_ENST00000356487_COG4_chr16_70553634_ENST00000323786_length(amino acids)=889AA_BP=156
MLRAAGAPSSSARVSLSVPSSPAMAALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHILVDYSKNLVTEDVMRM
LVDLAKSRGVEAARERMFNGEKINYTEGRAVLHVALRNRSNTPILVDGKDVMPEVNKVLDKMKSFCQKVVERELDALLEQQNTIESKMVT
LHRMGPNLQLIEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRSEDYEQAAAHTHRYLCLDK
SVIELSRQGKEGSMIDANLKLLQEAEQRLKAIVAEKFAIATKEGDLPQVERFFKIFPLLGLHEEGLRKFSEYLCKQVASKAEENLLMVLG
TDMSDRRAAVIFADTLTLLFEGIARIVETHQPIVETYYGPGRLYTLIKYLQVECDRQVEKVVDKFIKQRDYHQQFRHVQNNLMRNSTTEK
IEPRELDPILTEVTLMNARSELYLRFLKKRISSDFEVGDSMASEEVKQEHQKCLDKLLNNCLLSCTMQELIGLYVTMEEYFMRETVNKAV
ALDTYEKGQLTSSMVDDVFYIVKKCIGRALSSSSIDCLCAMINLATTELESDFRDVLCNKLRMGFPATTFQDIQRGVTSAVNIMHSSLQQ
GKFDTKGIESTDEAKMSFLVTLNNVEVCSENISTLKKTLESDCTKLFSQGIGGEQAQAKFDSCLSDLAAVSNKFRDLLQEGLTELNSTAI
KPQVQPWINSFFSVSHNIEEEEFNDYEANDPWVQQFILNLEQQMAEFKASLSPVIYDSLTGLMTSLVAVELEKVVLKSTFNRLGGLQFDK

--------------------------------------------------------------
>34281_34281_2_GPI-COG4_GPI_chr19_34859607_ENST00000356487_COG4_chr16_70553634_ENST00000393612_length(transcript)=1498nt_BP=643nt
AGAGAGGAGCTGAGGCCCCAGATCAGCGGCCGCGGGCAAGGTCGCTCAGCGGGCACCCGGCCTGGGTATCGGGGCGCGGGTCGGGGGCGG
GGCCGGGGCTCAGGGGTGGGGCCGGGCCGGGCCGGGCCGGGCGCCTGCGCCATAAAGGCCGCCGCGCGCCCACGCGCCTCGCTTGCTGCG
CGCTGCCGGCGCTCCTTCCTCCTCGGCTCGCGTCTCACTCAGTGTACCTTCTAGTCCCGCCATGGCCGCTCTCACCCGGGACCCCCAGTT
CCAGAAGCTGCAGCAATGGTACCGCGAGCACCGCTCCGAGCTGAACCTGCGCCGCCTCTTCGATGCCAACAAGGACCGCTTCAACCACTT
CAGCTTGACCCTCAACACCAACCATGGGCATATCCTGGTGGATTACTCCAAGAACCTGGTGACGGAGGACGTGATGCGGATGCTGGTGGA
CTTGGCCAAGTCCAGGGGCGTGGAGGCCGCCCGGGAGCGGATGTTCAATGGTGAGAAGATCAACTACACCGAGGGTCGAGCCGTGCTGCA
CGTGGCTCTGCGGAACCGGTCAAACACACCCATCCTGGTAGACGGCAAGGATGTGATGCCAGAGGTCAACAAGGTTCTGGACAAGATGAA
GTCTTTCTGCCAGAAAGTGGTGGAGAGAGAGCTGGATGCTCTTTTGGAACAGCAAAACACCATTGAAAGTAAGATGGTCACTCTCCACCG
AATGGGTCCTAATCTGCAGCTGATTGAGGGAGATGCAAAGCAGCTGGCTGGAATGATCACCTTTACCTGCAACCTGGCTGAGAATGTGTC
CAGCAAAGTTCGTCAGCTTGACCTGGCCAAGAACCGCCTCTATCAGGCCATTCAGAGAGCTGATGACATCTTGGACCTGAAGTTCTGCAT
GGATGGAGTTCAGACTGCTTTGAGGAGTGAAGATTATGAGCAGGCTGCAGCACATACTCATCGCTACTTGTGCCTGGACAAGTCGGTCAT
TGAGCTCAGCCGACAGGGCAAAGAGGGGAGCATGATTGATGCCAACCTGAAATTGCTGCAGGAAGCTGAGCAACGTCTCAAAGCCATTGT
GGCAGAGAAGTTTGCCATTGCCACCAAGGAAGGTGATCTGCCCCAGGTGGAGCGCTTCTTCAAGATCTTCCCACTGCTGGGTTTGCATGA
GGAGGGATTAAGAAAGTTCTCGGAGTACCTTTGCAAGCAGGTGGCCAGTAAAGCTGAGGAGAATCTGCTCATGGTGCTGGGGACAGACAT
GAGTGATCGGAGAGCTGCAGTCATCTTTGCAGATACACTTACTCTTCTGTTTGAAGGGATTGCCCGCATTGTGGAGACCCACCAGCCAAT
AGTGGAGACCTATTATGGGCCAGGGAGACTCTATACCCTGATCAAATATCTGCAGGTGGAATGTGACAGACAGGTGGAGAAGGTGGTAGA

>34281_34281_2_GPI-COG4_GPI_chr19_34859607_ENST00000356487_COG4_chr16_70553634_ENST00000393612_length(amino acids)=442AA_BP=156
MLRAAGAPSSSARVSLSVPSSPAMAALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHILVDYSKNLVTEDVMRM
LVDLAKSRGVEAARERMFNGEKINYTEGRAVLHVALRNRSNTPILVDGKDVMPEVNKVLDKMKSFCQKVVERELDALLEQQNTIESKMVT
LHRMGPNLQLIEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRSEDYEQAAAHTHRYLCLDK
SVIELSRQGKEGSMIDANLKLLQEAEQRLKAIVAEKFAIATKEGDLPQVERFFKIFPLLGLHEEGLRKFSEYLCKQVASKAEENLLMVLG

--------------------------------------------------------------
>34281_34281_3_GPI-COG4_GPI_chr19_34859607_ENST00000356487_COG4_chr16_70553634_ENST00000564653_length(transcript)=1055nt_BP=643nt
AGAGAGGAGCTGAGGCCCCAGATCAGCGGCCGCGGGCAAGGTCGCTCAGCGGGCACCCGGCCTGGGTATCGGGGCGCGGGTCGGGGGCGG
GGCCGGGGCTCAGGGGTGGGGCCGGGCCGGGCCGGGCCGGGCGCCTGCGCCATAAAGGCCGCCGCGCGCCCACGCGCCTCGCTTGCTGCG
CGCTGCCGGCGCTCCTTCCTCCTCGGCTCGCGTCTCACTCAGTGTACCTTCTAGTCCCGCCATGGCCGCTCTCACCCGGGACCCCCAGTT
CCAGAAGCTGCAGCAATGGTACCGCGAGCACCGCTCCGAGCTGAACCTGCGCCGCCTCTTCGATGCCAACAAGGACCGCTTCAACCACTT
CAGCTTGACCCTCAACACCAACCATGGGCATATCCTGGTGGATTACTCCAAGAACCTGGTGACGGAGGACGTGATGCGGATGCTGGTGGA
CTTGGCCAAGTCCAGGGGCGTGGAGGCCGCCCGGGAGCGGATGTTCAATGGTGAGAAGATCAACTACACCGAGGGTCGAGCCGTGCTGCA
CGTGGCTCTGCGGAACCGGTCAAACACACCCATCCTGGTAGACGGCAAGGATGTGATGCCAGAGGTCAACAAGGTTCTGGACAAGATGAA
GTCTTTCTGCCAGAAAGTGGTGGAGAGAGAGCTGGATGCTCTTTTGGAACAGCAAAACACCATTGAAAGTAAGATGGTCACTCTCCACCG
AATGGGTCCTAATCTGCAGCTGATTGAGGGAGATGCAAAGCAGCTGGCTGGAATGATCACCTTTACCTGCAACCTGGCTGAGAATGTGTC
CAGCAAAGTTCGTCAGCTTGACCTGGCCAAGAACCGCCTCTATCAGGCCATTCAGAGAGCTGATGACATCTTGGACCTGAAGTTCTGCAT
GGATGGAGTTCAGACTGCTTTGAGGAGTGAAGATTATGAGCAGGCTGCAGCACATACTCATCGCTACTTGTGCCTGGACAAGTCGGTGAT

>34281_34281_3_GPI-COG4_GPI_chr19_34859607_ENST00000356487_COG4_chr16_70553634_ENST00000564653_length(amino acids)=294AA_BP=156
MLRAAGAPSSSARVSLSVPSSPAMAALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHILVDYSKNLVTEDVMRM
LVDLAKSRGVEAARERMFNGEKINYTEGRAVLHVALRNRSNTPILVDGKDVMPEVNKVLDKMKSFCQKVVERELDALLEQQNTIESKMVT
LHRMGPNLQLIEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRSEDYEQAAAHTHRYLCLDK

--------------------------------------------------------------
>34281_34281_4_GPI-COG4_GPI_chr19_34859607_ENST00000415930_COG4_chr16_70553634_ENST00000323786_length(transcript)=3329nt_BP=689nt
AATAGCCCTTACCACCAGCAGACACACATCATCTGTTGTACTTGCTTATTTGGCACATATGTATCCACAGCGCCTAGAACACTGCCTGTA
ACGTGGAAGGTGTTCGATCTATAGAGTTTTGTCGAATGAATGAATGAAGCCGACTAGTGCACAGGGAGTGCAGCGGCGCGATGGTAGCTC
TCTGCAGCCTCCAACACCTGGGCTCCAGTGATCCCCGGGCTCTGCCCACCCTCCCCACTGCCACTTCCGGGCAGAGGCCAGCAAAGCGGC
GGCGCAAGAGTCCCGCCATGGCCGCTCTCACCCGGGACCCCCAGTTCCAGAAGCTGCAGCAATGGTACCGCGAGCACCGCTCCGAGCTGA
ACCTGCGCCGCCTCTTCGATGCCAACAAGGACCGCTTCAACCACTTCAGCTTGACCCTCAACACCAACCATGGGCATATCCTGGTGGATT
ACTCCAAGAACCTGGTGACGGAGGACGTGATGCGGATGCTGGTGGACTTGGCCAAGTCCAGGGGCGTGGAGGCCGCCCGGGAGCGGATGT
TCAATGGTGAGAAGATCAACTACACCGAGGGTCGAGCCGTGCTGCACGTGGCTCTGCGGAACCGGTCAAACACACCCATCCTGGTAGACG
GCAAGGATGTGATGCCAGAGGTCAACAAGGTTCTGGACAAGATGAAGTCTTTCTGCCAGAAAGTGGTGGAGAGAGAGCTGGATGCTCTTT
TGGAACAGCAAAACACCATTGAAAGTAAGATGGTCACTCTCCACCGAATGGGTCCTAATCTGCAGCTGATTGAGGGAGATGCAAAGCAGC
TGGCTGGAATGATCACCTTTACCTGCAACCTGGCTGAGAATGTGTCCAGCAAAGTTCGTCAGCTTGACCTGGCCAAGAACCGCCTCTATC
AGGCCATTCAGAGAGCTGATGACATCTTGGACCTGAAGTTCTGCATGGATGGAGTTCAGACTGCTTTGAGGAGTGAAGATTATGAGCAGG
CTGCAGCACATACTCATCGCTACTTGTGCCTGGACAAGTCGGTCATTGAGCTCAGCCGACAGGGCAAAGAGGGGAGCATGATTGATGCCA
ACCTGAAATTGCTGCAGGAAGCTGAGCAACGTCTCAAAGCCATTGTGGCAGAGAAGTTTGCCATTGCCACCAAGGAAGGTGATCTGCCCC
AGGTGGAGCGCTTCTTCAAGATCTTCCCACTGCTGGGTTTGCATGAGGAGGGATTAAGAAAGTTCTCGGAGTACCTTTGCAAGCAGGTGG
CCAGTAAAGCTGAGGAGAATCTGCTCATGGTGCTGGGGACAGACATGAGTGATCGGAGAGCTGCAGTCATCTTTGCAGATACACTTACTC
TTCTGTTTGAAGGGATTGCCCGCATTGTGGAGACCCACCAGCCAATAGTGGAGACCTATTATGGGCCAGGGAGACTCTATACCCTGATCA
AATATCTGCAGGTGGAATGTGACAGACAGGTGGAGAAGGTGGTAGACAAGTTCATCAAGCAAAGGGACTACCACCAGCAGTTCCGGCATG
TTCAGAACAACCTGATGAGAAATTCTACAACAGAAAAAATCGAACCAAGAGAACTGGACCCCATCCTGACTGAGGTCACCCTGATGAATG
CCCGCAGTGAGCTATACTTACGCTTCCTCAAGAAGAGGATTAGCTCTGATTTTGAGGTGGGAGACTCCATGGCCTCAGAGGAAGTAAAGC
AAGAGCACCAGAAGTGTCTGGACAAACTCCTCAATAACTGCCTTTTGAGCTGTACCATGCAGGAGCTAATTGGCTTATATGTTACCATGG
AGGAGTACTTCATGAGGGAGACTGTCAATAAGGCTGTGGCTCTGGACACCTATGAGAAGGGCCAGCTGACATCCAGCATGGTGGATGATG
TCTTCTACATTGTTAAGAAGTGCATTGGGCGGGCTCTGTCCAGCTCCAGCATTGACTGTCTCTGTGCCATGATCAACCTCGCCACCACAG
AGCTGGAGTCTGACTTCAGGGATGTTCTGTGTAATAAGCTGCGGATGGGCTTTCCTGCCACCACCTTCCAGGACATCCAGCGCGGGGTGA
CAAGTGCCGTGAACATCATGCACAGCAGCCTCCAGCAAGGCAAATTTGACACAAAAGGCATCGAGAGTACTGACGAGGCGAAGATGTCCT
TCCTGGTGACTCTGAACAACGTGGAAGTCTGCAGTGAAAACATCTCCACTCTGAAGAAGACACTGGAGAGTGACTGCACCAAGCTCTTCA
GCCAGGGCATTGGAGGGGAGCAGGCCCAGGCCAAGTTTGACAGCTGCCTTTCTGACTTGGCCGCCGTGTCCAACAAATTCCGAGACCTCT
TGCAGGAAGGGCTGACGGAGCTCAACAGCACAGCCATCAAGCCACAGGTGCAGCCTTGGATCAACAGCTTTTTCTCCGTCTCCCACAACA
TCGAGGAGGAAGAATTCAATGACTATGAGGCCAACGACCCTTGGGTACAACAGTTCATCCTTAACCTGGAGCAGCAAATGGCAGAGTTCA
AGGCCAGCCTGTCCCCGGTCATCTACGACAGCCTAACCGGCCTCATGACTAGCCTTGTTGCCGTCGAGTTGGAGAAAGTGGTGCTGAAAT
CCACCTTTAACCGGCTGGGTGGTCTGCAGTTTGACAAGGAGCTGAGGTCGCTCATTGCCTACCTTACCACGGTGACCACCTGGACCATCC
GAGACAAGTTTGCCCGGCTCTCCCAGATGGCCACCATCCTCAATCTGGAGCGGGTGACCGAGATCCTCGATTACTGGGGACCCAATTCCG
GCCCATTGACGTGGCGCCTCACCCCTGCTGAAGTGCGCCAGGTGCTGGCCCTGCGGATAGACTTCCGCAGTGAAGATATCAAGAGGCTGC
GCCTGTAGCTGCCTGGATGAGCACACCTGGCTCATCACACTTGCAGGCCTGTTCCCTAAGGGGCCCCAGCCAAGGAGCTGAGCGAGGCTG
TCTGGCTTGGGGGAGATCTGACAGCCCAGACCTTTCTACGGCTGGCAGCAGAGAAACAAAGTCTGGACCCACTCCATGCTCTGCCCTCAG
ACCTGGCCAGGTGATGCTCTGGGGGCAGCATCTCCCCACCGAGAGAAGCGGGCTCCTAATGAGGTGGGAAAGCCACGGCAGGCAGCGAGC
AGCCCAGGCCAGCTTTCTGCATGGATGGTCAGTCTCTTGCCCTCAAACACTACAGCAAACAAGCTACCCCTGCCAGTCCTAGACAACTTG

>34281_34281_4_GPI-COG4_GPI_chr19_34859607_ENST00000415930_COG4_chr16_70553634_ENST00000323786_length(amino acids)=905AA_BP=172
MVALCSLQHLGSSDPRALPTLPTATSGQRPAKRRRKSPAMAALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHI
LVDYSKNLVTEDVMRMLVDLAKSRGVEAARERMFNGEKINYTEGRAVLHVALRNRSNTPILVDGKDVMPEVNKVLDKMKSFCQKVVEREL
DALLEQQNTIESKMVTLHRMGPNLQLIEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRSED
YEQAAAHTHRYLCLDKSVIELSRQGKEGSMIDANLKLLQEAEQRLKAIVAEKFAIATKEGDLPQVERFFKIFPLLGLHEEGLRKFSEYLC
KQVASKAEENLLMVLGTDMSDRRAAVIFADTLTLLFEGIARIVETHQPIVETYYGPGRLYTLIKYLQVECDRQVEKVVDKFIKQRDYHQQ
FRHVQNNLMRNSTTEKIEPRELDPILTEVTLMNARSELYLRFLKKRISSDFEVGDSMASEEVKQEHQKCLDKLLNNCLLSCTMQELIGLY
VTMEEYFMRETVNKAVALDTYEKGQLTSSMVDDVFYIVKKCIGRALSSSSIDCLCAMINLATTELESDFRDVLCNKLRMGFPATTFQDIQ
RGVTSAVNIMHSSLQQGKFDTKGIESTDEAKMSFLVTLNNVEVCSENISTLKKTLESDCTKLFSQGIGGEQAQAKFDSCLSDLAAVSNKF
RDLLQEGLTELNSTAIKPQVQPWINSFFSVSHNIEEEEFNDYEANDPWVQQFILNLEQQMAEFKASLSPVIYDSLTGLMTSLVAVELEKV
VLKSTFNRLGGLQFDKELRSLIAYLTTVTTWTIRDKFARLSQMATILNLERVTEILDYWGPNSGPLTWRLTPAEVRQVLALRIDFRSEDI

--------------------------------------------------------------
>34281_34281_5_GPI-COG4_GPI_chr19_34859607_ENST00000415930_COG4_chr16_70553634_ENST00000393612_length(transcript)=1544nt_BP=689nt
AATAGCCCTTACCACCAGCAGACACACATCATCTGTTGTACTTGCTTATTTGGCACATATGTATCCACAGCGCCTAGAACACTGCCTGTA
ACGTGGAAGGTGTTCGATCTATAGAGTTTTGTCGAATGAATGAATGAAGCCGACTAGTGCACAGGGAGTGCAGCGGCGCGATGGTAGCTC
TCTGCAGCCTCCAACACCTGGGCTCCAGTGATCCCCGGGCTCTGCCCACCCTCCCCACTGCCACTTCCGGGCAGAGGCCAGCAAAGCGGC
GGCGCAAGAGTCCCGCCATGGCCGCTCTCACCCGGGACCCCCAGTTCCAGAAGCTGCAGCAATGGTACCGCGAGCACCGCTCCGAGCTGA
ACCTGCGCCGCCTCTTCGATGCCAACAAGGACCGCTTCAACCACTTCAGCTTGACCCTCAACACCAACCATGGGCATATCCTGGTGGATT
ACTCCAAGAACCTGGTGACGGAGGACGTGATGCGGATGCTGGTGGACTTGGCCAAGTCCAGGGGCGTGGAGGCCGCCCGGGAGCGGATGT
TCAATGGTGAGAAGATCAACTACACCGAGGGTCGAGCCGTGCTGCACGTGGCTCTGCGGAACCGGTCAAACACACCCATCCTGGTAGACG
GCAAGGATGTGATGCCAGAGGTCAACAAGGTTCTGGACAAGATGAAGTCTTTCTGCCAGAAAGTGGTGGAGAGAGAGCTGGATGCTCTTT
TGGAACAGCAAAACACCATTGAAAGTAAGATGGTCACTCTCCACCGAATGGGTCCTAATCTGCAGCTGATTGAGGGAGATGCAAAGCAGC
TGGCTGGAATGATCACCTTTACCTGCAACCTGGCTGAGAATGTGTCCAGCAAAGTTCGTCAGCTTGACCTGGCCAAGAACCGCCTCTATC
AGGCCATTCAGAGAGCTGATGACATCTTGGACCTGAAGTTCTGCATGGATGGAGTTCAGACTGCTTTGAGGAGTGAAGATTATGAGCAGG
CTGCAGCACATACTCATCGCTACTTGTGCCTGGACAAGTCGGTCATTGAGCTCAGCCGACAGGGCAAAGAGGGGAGCATGATTGATGCCA
ACCTGAAATTGCTGCAGGAAGCTGAGCAACGTCTCAAAGCCATTGTGGCAGAGAAGTTTGCCATTGCCACCAAGGAAGGTGATCTGCCCC
AGGTGGAGCGCTTCTTCAAGATCTTCCCACTGCTGGGTTTGCATGAGGAGGGATTAAGAAAGTTCTCGGAGTACCTTTGCAAGCAGGTGG
CCAGTAAAGCTGAGGAGAATCTGCTCATGGTGCTGGGGACAGACATGAGTGATCGGAGAGCTGCAGTCATCTTTGCAGATACACTTACTC
TTCTGTTTGAAGGGATTGCCCGCATTGTGGAGACCCACCAGCCAATAGTGGAGACCTATTATGGGCCAGGGAGACTCTATACCCTGATCA
AATATCTGCAGGTGGAATGTGACAGACAGGTGGAGAAGGTGGTAGACAAGTTCATCAAGCAAAGGGACTACCACCAGCAGAACTTTGTTT

>34281_34281_5_GPI-COG4_GPI_chr19_34859607_ENST00000415930_COG4_chr16_70553634_ENST00000393612_length(amino acids)=458AA_BP=172
MVALCSLQHLGSSDPRALPTLPTATSGQRPAKRRRKSPAMAALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHI
LVDYSKNLVTEDVMRMLVDLAKSRGVEAARERMFNGEKINYTEGRAVLHVALRNRSNTPILVDGKDVMPEVNKVLDKMKSFCQKVVEREL
DALLEQQNTIESKMVTLHRMGPNLQLIEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRSED
YEQAAAHTHRYLCLDKSVIELSRQGKEGSMIDANLKLLQEAEQRLKAIVAEKFAIATKEGDLPQVERFFKIFPLLGLHEEGLRKFSEYLC
KQVASKAEENLLMVLGTDMSDRRAAVIFADTLTLLFEGIARIVETHQPIVETYYGPGRLYTLIKYLQVECDRQVEKVVDKFIKQRDYHQQ

--------------------------------------------------------------
>34281_34281_6_GPI-COG4_GPI_chr19_34859607_ENST00000415930_COG4_chr16_70553634_ENST00000564653_length(transcript)=1101nt_BP=689nt
AATAGCCCTTACCACCAGCAGACACACATCATCTGTTGTACTTGCTTATTTGGCACATATGTATCCACAGCGCCTAGAACACTGCCTGTA
ACGTGGAAGGTGTTCGATCTATAGAGTTTTGTCGAATGAATGAATGAAGCCGACTAGTGCACAGGGAGTGCAGCGGCGCGATGGTAGCTC
TCTGCAGCCTCCAACACCTGGGCTCCAGTGATCCCCGGGCTCTGCCCACCCTCCCCACTGCCACTTCCGGGCAGAGGCCAGCAAAGCGGC
GGCGCAAGAGTCCCGCCATGGCCGCTCTCACCCGGGACCCCCAGTTCCAGAAGCTGCAGCAATGGTACCGCGAGCACCGCTCCGAGCTGA
ACCTGCGCCGCCTCTTCGATGCCAACAAGGACCGCTTCAACCACTTCAGCTTGACCCTCAACACCAACCATGGGCATATCCTGGTGGATT
ACTCCAAGAACCTGGTGACGGAGGACGTGATGCGGATGCTGGTGGACTTGGCCAAGTCCAGGGGCGTGGAGGCCGCCCGGGAGCGGATGT
TCAATGGTGAGAAGATCAACTACACCGAGGGTCGAGCCGTGCTGCACGTGGCTCTGCGGAACCGGTCAAACACACCCATCCTGGTAGACG
GCAAGGATGTGATGCCAGAGGTCAACAAGGTTCTGGACAAGATGAAGTCTTTCTGCCAGAAAGTGGTGGAGAGAGAGCTGGATGCTCTTT
TGGAACAGCAAAACACCATTGAAAGTAAGATGGTCACTCTCCACCGAATGGGTCCTAATCTGCAGCTGATTGAGGGAGATGCAAAGCAGC
TGGCTGGAATGATCACCTTTACCTGCAACCTGGCTGAGAATGTGTCCAGCAAAGTTCGTCAGCTTGACCTGGCCAAGAACCGCCTCTATC
AGGCCATTCAGAGAGCTGATGACATCTTGGACCTGAAGTTCTGCATGGATGGAGTTCAGACTGCTTTGAGGAGTGAAGATTATGAGCAGG
CTGCAGCACATACTCATCGCTACTTGTGCCTGGACAAGTCGGTGATCTGCCCCAGGTGGAGCGCTTCTTCAAGATCTTCCCACTGCTGGG

>34281_34281_6_GPI-COG4_GPI_chr19_34859607_ENST00000415930_COG4_chr16_70553634_ENST00000564653_length(amino acids)=309AA_BP=172
MVALCSLQHLGSSDPRALPTLPTATSGQRPAKRRRKSPAMAALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHI
LVDYSKNLVTEDVMRMLVDLAKSRGVEAARERMFNGEKINYTEGRAVLHVALRNRSNTPILVDGKDVMPEVNKVLDKMKSFCQKVVEREL
DALLEQQNTIESKMVTLHRMGPNLQLIEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRSED

--------------------------------------------------------------
>34281_34281_7_GPI-COG4_GPI_chr19_34859607_ENST00000586425_COG4_chr16_70553634_ENST00000323786_length(transcript)=3067nt_BP=427nt
ACTCAGTGTACCTTCTAGTCCCGCCATGGCCGCTCTCACCCGGGACCCCCAGTTCCAGAAGCTGCAGCAATGGTACCGCGAGCACCGCTC
CGAGCTGAACCTGCGCCGCCTCTTCGATGCCAACAAGGACCGCTTCAACCACTTCAGCTTGACCCTCAACACCAACCATGGGCATATCCT
GGTGGATTACTCCAAGAACCTGGTGACGGAGGACGTGATGCGGATGCTGGTGGACTTGGCCAAGTCCAGGGGCGTGGAGGCCGCCCGGGA
GCGGATGTTCAATGGTGAGAAGATCAACTACACCGAGGGTCGAGCCGTGCTGCACGTGGCTCTGCGGAACCGGTCAAACACACCCATCCT
GGTAGACGGCAAGGATGTGATGCCAGAGGTCAACAAGGTTCTGGACAAGATGAAGTCTTTCTGCCAGAAAGTGGTGGAGAGAGAGCTGGA
TGCTCTTTTGGAACAGCAAAACACCATTGAAAGTAAGATGGTCACTCTCCACCGAATGGGTCCTAATCTGCAGCTGATTGAGGGAGATGC
AAAGCAGCTGGCTGGAATGATCACCTTTACCTGCAACCTGGCTGAGAATGTGTCCAGCAAAGTTCGTCAGCTTGACCTGGCCAAGAACCG
CCTCTATCAGGCCATTCAGAGAGCTGATGACATCTTGGACCTGAAGTTCTGCATGGATGGAGTTCAGACTGCTTTGAGGAGTGAAGATTA
TGAGCAGGCTGCAGCACATACTCATCGCTACTTGTGCCTGGACAAGTCGGTCATTGAGCTCAGCCGACAGGGCAAAGAGGGGAGCATGAT
TGATGCCAACCTGAAATTGCTGCAGGAAGCTGAGCAACGTCTCAAAGCCATTGTGGCAGAGAAGTTTGCCATTGCCACCAAGGAAGGTGA
TCTGCCCCAGGTGGAGCGCTTCTTCAAGATCTTCCCACTGCTGGGTTTGCATGAGGAGGGATTAAGAAAGTTCTCGGAGTACCTTTGCAA
GCAGGTGGCCAGTAAAGCTGAGGAGAATCTGCTCATGGTGCTGGGGACAGACATGAGTGATCGGAGAGCTGCAGTCATCTTTGCAGATAC
ACTTACTCTTCTGTTTGAAGGGATTGCCCGCATTGTGGAGACCCACCAGCCAATAGTGGAGACCTATTATGGGCCAGGGAGACTCTATAC
CCTGATCAAATATCTGCAGGTGGAATGTGACAGACAGGTGGAGAAGGTGGTAGACAAGTTCATCAAGCAAAGGGACTACCACCAGCAGTT
CCGGCATGTTCAGAACAACCTGATGAGAAATTCTACAACAGAAAAAATCGAACCAAGAGAACTGGACCCCATCCTGACTGAGGTCACCCT
GATGAATGCCCGCAGTGAGCTATACTTACGCTTCCTCAAGAAGAGGATTAGCTCTGATTTTGAGGTGGGAGACTCCATGGCCTCAGAGGA
AGTAAAGCAAGAGCACCAGAAGTGTCTGGACAAACTCCTCAATAACTGCCTTTTGAGCTGTACCATGCAGGAGCTAATTGGCTTATATGT
TACCATGGAGGAGTACTTCATGAGGGAGACTGTCAATAAGGCTGTGGCTCTGGACACCTATGAGAAGGGCCAGCTGACATCCAGCATGGT
GGATGATGTCTTCTACATTGTTAAGAAGTGCATTGGGCGGGCTCTGTCCAGCTCCAGCATTGACTGTCTCTGTGCCATGATCAACCTCGC
CACCACAGAGCTGGAGTCTGACTTCAGGGATGTTCTGTGTAATAAGCTGCGGATGGGCTTTCCTGCCACCACCTTCCAGGACATCCAGCG
CGGGGTGACAAGTGCCGTGAACATCATGCACAGCAGCCTCCAGCAAGGCAAATTTGACACAAAAGGCATCGAGAGTACTGACGAGGCGAA
GATGTCCTTCCTGGTGACTCTGAACAACGTGGAAGTCTGCAGTGAAAACATCTCCACTCTGAAGAAGACACTGGAGAGTGACTGCACCAA
GCTCTTCAGCCAGGGCATTGGAGGGGAGCAGGCCCAGGCCAAGTTTGACAGCTGCCTTTCTGACTTGGCCGCCGTGTCCAACAAATTCCG
AGACCTCTTGCAGGAAGGGCTGACGGAGCTCAACAGCACAGCCATCAAGCCACAGGTGCAGCCTTGGATCAACAGCTTTTTCTCCGTCTC
CCACAACATCGAGGAGGAAGAATTCAATGACTATGAGGCCAACGACCCTTGGGTACAACAGTTCATCCTTAACCTGGAGCAGCAAATGGC
AGAGTTCAAGGCCAGCCTGTCCCCGGTCATCTACGACAGCCTAACCGGCCTCATGACTAGCCTTGTTGCCGTCGAGTTGGAGAAAGTGGT
GCTGAAATCCACCTTTAACCGGCTGGGTGGTCTGCAGTTTGACAAGGAGCTGAGGTCGCTCATTGCCTACCTTACCACGGTGACCACCTG
GACCATCCGAGACAAGTTTGCCCGGCTCTCCCAGATGGCCACCATCCTCAATCTGGAGCGGGTGACCGAGATCCTCGATTACTGGGGACC
CAATTCCGGCCCATTGACGTGGCGCCTCACCCCTGCTGAAGTGCGCCAGGTGCTGGCCCTGCGGATAGACTTCCGCAGTGAAGATATCAA
GAGGCTGCGCCTGTAGCTGCCTGGATGAGCACACCTGGCTCATCACACTTGCAGGCCTGTTCCCTAAGGGGCCCCAGCCAAGGAGCTGAG
CGAGGCTGTCTGGCTTGGGGGAGATCTGACAGCCCAGACCTTTCTACGGCTGGCAGCAGAGAAACAAAGTCTGGACCCACTCCATGCTCT
GCCCTCAGACCTGGCCAGGTGATGCTCTGGGGGCAGCATCTCCCCACCGAGAGAAGCGGGCTCCTAATGAGGTGGGAAAGCCACGGCAGG
CAGCGAGCAGCCCAGGCCAGCTTTCTGCATGGATGGTCAGTCTCTTGCCCTCAAACACTACAGCAAACAAGCTACCCCTGCCAGTCCTAG
ACAACTTGGGTACATCTGGGGACCTAGCAGTTAGGCTTGACTTTGAGGAGAGGCTGTGATGTTTATGATCCCTGAATAAAGCTACTCCTT

>34281_34281_7_GPI-COG4_GPI_chr19_34859607_ENST00000586425_COG4_chr16_70553634_ENST00000323786_length(amino acids)=866AA_BP=133
MAALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHILVDYSKNLVTEDVMRMLVDLAKSRGVEAARERMFNGEKI
NYTEGRAVLHVALRNRSNTPILVDGKDVMPEVNKVLDKMKSFCQKVVERELDALLEQQNTIESKMVTLHRMGPNLQLIEGDAKQLAGMIT
FTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRSEDYEQAAAHTHRYLCLDKSVIELSRQGKEGSMIDANLKLLQ
EAEQRLKAIVAEKFAIATKEGDLPQVERFFKIFPLLGLHEEGLRKFSEYLCKQVASKAEENLLMVLGTDMSDRRAAVIFADTLTLLFEGI
ARIVETHQPIVETYYGPGRLYTLIKYLQVECDRQVEKVVDKFIKQRDYHQQFRHVQNNLMRNSTTEKIEPRELDPILTEVTLMNARSELY
LRFLKKRISSDFEVGDSMASEEVKQEHQKCLDKLLNNCLLSCTMQELIGLYVTMEEYFMRETVNKAVALDTYEKGQLTSSMVDDVFYIVK
KCIGRALSSSSIDCLCAMINLATTELESDFRDVLCNKLRMGFPATTFQDIQRGVTSAVNIMHSSLQQGKFDTKGIESTDEAKMSFLVTLN
NVEVCSENISTLKKTLESDCTKLFSQGIGGEQAQAKFDSCLSDLAAVSNKFRDLLQEGLTELNSTAIKPQVQPWINSFFSVSHNIEEEEF
NDYEANDPWVQQFILNLEQQMAEFKASLSPVIYDSLTGLMTSLVAVELEKVVLKSTFNRLGGLQFDKELRSLIAYLTTVTTWTIRDKFAR

--------------------------------------------------------------
>34281_34281_8_GPI-COG4_GPI_chr19_34859607_ENST00000586425_COG4_chr16_70553634_ENST00000393612_length(transcript)=1282nt_BP=427nt
ACTCAGTGTACCTTCTAGTCCCGCCATGGCCGCTCTCACCCGGGACCCCCAGTTCCAGAAGCTGCAGCAATGGTACCGCGAGCACCGCTC
CGAGCTGAACCTGCGCCGCCTCTTCGATGCCAACAAGGACCGCTTCAACCACTTCAGCTTGACCCTCAACACCAACCATGGGCATATCCT
GGTGGATTACTCCAAGAACCTGGTGACGGAGGACGTGATGCGGATGCTGGTGGACTTGGCCAAGTCCAGGGGCGTGGAGGCCGCCCGGGA
GCGGATGTTCAATGGTGAGAAGATCAACTACACCGAGGGTCGAGCCGTGCTGCACGTGGCTCTGCGGAACCGGTCAAACACACCCATCCT
GGTAGACGGCAAGGATGTGATGCCAGAGGTCAACAAGGTTCTGGACAAGATGAAGTCTTTCTGCCAGAAAGTGGTGGAGAGAGAGCTGGA
TGCTCTTTTGGAACAGCAAAACACCATTGAAAGTAAGATGGTCACTCTCCACCGAATGGGTCCTAATCTGCAGCTGATTGAGGGAGATGC
AAAGCAGCTGGCTGGAATGATCACCTTTACCTGCAACCTGGCTGAGAATGTGTCCAGCAAAGTTCGTCAGCTTGACCTGGCCAAGAACCG
CCTCTATCAGGCCATTCAGAGAGCTGATGACATCTTGGACCTGAAGTTCTGCATGGATGGAGTTCAGACTGCTTTGAGGAGTGAAGATTA
TGAGCAGGCTGCAGCACATACTCATCGCTACTTGTGCCTGGACAAGTCGGTCATTGAGCTCAGCCGACAGGGCAAAGAGGGGAGCATGAT
TGATGCCAACCTGAAATTGCTGCAGGAAGCTGAGCAACGTCTCAAAGCCATTGTGGCAGAGAAGTTTGCCATTGCCACCAAGGAAGGTGA
TCTGCCCCAGGTGGAGCGCTTCTTCAAGATCTTCCCACTGCTGGGTTTGCATGAGGAGGGATTAAGAAAGTTCTCGGAGTACCTTTGCAA
GCAGGTGGCCAGTAAAGCTGAGGAGAATCTGCTCATGGTGCTGGGGACAGACATGAGTGATCGGAGAGCTGCAGTCATCTTTGCAGATAC
ACTTACTCTTCTGTTTGAAGGGATTGCCCGCATTGTGGAGACCCACCAGCCAATAGTGGAGACCTATTATGGGCCAGGGAGACTCTATAC
CCTGATCAAATATCTGCAGGTGGAATGTGACAGACAGGTGGAGAAGGTGGTAGACAAGTTCATCAAGCAAAGGGACTACCACCAGCAGAA

>34281_34281_8_GPI-COG4_GPI_chr19_34859607_ENST00000586425_COG4_chr16_70553634_ENST00000393612_length(amino acids)=419AA_BP=133
MAALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHILVDYSKNLVTEDVMRMLVDLAKSRGVEAARERMFNGEKI
NYTEGRAVLHVALRNRSNTPILVDGKDVMPEVNKVLDKMKSFCQKVVERELDALLEQQNTIESKMVTLHRMGPNLQLIEGDAKQLAGMIT
FTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRSEDYEQAAAHTHRYLCLDKSVIELSRQGKEGSMIDANLKLLQ
EAEQRLKAIVAEKFAIATKEGDLPQVERFFKIFPLLGLHEEGLRKFSEYLCKQVASKAEENLLMVLGTDMSDRRAAVIFADTLTLLFEGI

--------------------------------------------------------------
>34281_34281_9_GPI-COG4_GPI_chr19_34859607_ENST00000586425_COG4_chr16_70553634_ENST00000564653_length(transcript)=839nt_BP=427nt
ACTCAGTGTACCTTCTAGTCCCGCCATGGCCGCTCTCACCCGGGACCCCCAGTTCCAGAAGCTGCAGCAATGGTACCGCGAGCACCGCTC
CGAGCTGAACCTGCGCCGCCTCTTCGATGCCAACAAGGACCGCTTCAACCACTTCAGCTTGACCCTCAACACCAACCATGGGCATATCCT
GGTGGATTACTCCAAGAACCTGGTGACGGAGGACGTGATGCGGATGCTGGTGGACTTGGCCAAGTCCAGGGGCGTGGAGGCCGCCCGGGA
GCGGATGTTCAATGGTGAGAAGATCAACTACACCGAGGGTCGAGCCGTGCTGCACGTGGCTCTGCGGAACCGGTCAAACACACCCATCCT
GGTAGACGGCAAGGATGTGATGCCAGAGGTCAACAAGGTTCTGGACAAGATGAAGTCTTTCTGCCAGAAAGTGGTGGAGAGAGAGCTGGA
TGCTCTTTTGGAACAGCAAAACACCATTGAAAGTAAGATGGTCACTCTCCACCGAATGGGTCCTAATCTGCAGCTGATTGAGGGAGATGC
AAAGCAGCTGGCTGGAATGATCACCTTTACCTGCAACCTGGCTGAGAATGTGTCCAGCAAAGTTCGTCAGCTTGACCTGGCCAAGAACCG
CCTCTATCAGGCCATTCAGAGAGCTGATGACATCTTGGACCTGAAGTTCTGCATGGATGGAGTTCAGACTGCTTTGAGGAGTGAAGATTA
TGAGCAGGCTGCAGCACATACTCATCGCTACTTGTGCCTGGACAAGTCGGTGATCTGCCCCAGGTGGAGCGCTTCTTCAAGATCTTCCCA

>34281_34281_9_GPI-COG4_GPI_chr19_34859607_ENST00000586425_COG4_chr16_70553634_ENST00000564653_length(amino acids)=271AA_BP=133
MAALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHILVDYSKNLVTEDVMRMLVDLAKSRGVEAARERMFNGEKI
NYTEGRAVLHVALRNRSNTPILVDGKDVMPEVNKVLDKMKSFCQKVVERELDALLEQQNTIESKMVTLHRMGPNLQLIEGDAKQLAGMIT
FTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRSEDYEQAAAHTHRYLCLDKSVICPRWSASSRSSHCWVCMRRD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GPI-COG4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCOG4chr19:34859607chr16:70553634ENST000003936120885_15353.0338.0STX5


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneCOG4chr19:34859607chr16:70553634ENST00000393612082_8453.0338.0SCFD1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GPI-COG4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GPI-COG4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource