FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:GPI-POLG (FusionGDB2 ID:34298)

Fusion Gene Summary for GPI-POLG

check button Fusion gene summary
Fusion gene informationFusion gene name: GPI-POLG
Fusion gene ID: 34298
HgeneTgene
Gene symbol

GPI

POLG

Gene ID

10007

5428

Gene nameglucosamine-6-phosphate deaminase 1DNA polymerase gamma, catalytic subunit
SynonymsGNP1|GNPDA|GNPI|GPI|HLNMDP1|MIRAS|MTDPS4A|MTDPS4B|PEO|POLG1|POLGA|SANDO|SCAE
Cytomap

5q31.3

15q26.1

Type of geneprotein-codingprotein-coding
Descriptionglucosamine-6-phosphate isomerase 1GNPDA 1glcN6P deaminase 1oscillinDNA polymerase subunit gamma-1PolG-alphamitochondrial DNA polymerase catalytic subunitmitochondrial polymerase gamma catalytic subunitpolymerase (DNA directed), gammapolymerase (DNA) gamma, catalytic subunittruncated mitochondrial DNA polymerase gam
Modification date2020031320200325
UniProtAcc

PIGT

.
Ensembl transtripts involved in fusion geneENST00000356487, ENST00000415930, 
ENST00000586425, 		ENST00000525806, 
ENST00000268124, ENST00000442287, 
Fusion gene scores* DoF score27 X 23 X 11=68312 X 3 X 2=12
# samples 283
** MAII scorelog2(28/6831*10)=-4.60859805991281
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GPI [Title/Abstract] AND POLG [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGPI(34884673)-POLG(89876583), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePOLG

GO:0006261

DNA-dependent DNA replication

10608893|15167897|19837034|19858216|26123486|26446790|28430993

TgenePOLG

GO:0006287

base-excision repair, gap-filling

15177179


check buttonFusion gene breakpoints across GPI (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across POLG (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRPTCGA-B9-4115GPIchr19

34884673

+POLGchr15

89876583

-


Top

Fusion Gene ORF analysis for GPI-POLG

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000356487ENST00000525806GPIchr19

34884673

+POLGchr15

89876583

-
5CDS-intronENST00000415930ENST00000525806GPIchr19

34884673

+POLGchr15

89876583

-
5CDS-intronENST00000586425ENST00000525806GPIchr19

34884673

+POLGchr15

89876583

-
In-frameENST00000356487ENST00000268124GPIchr19

34884673

+POLGchr15

89876583

-
In-frameENST00000356487ENST00000442287GPIchr19

34884673

+POLGchr15

89876583

-
In-frameENST00000415930ENST00000268124GPIchr19

34884673

+POLGchr15

89876583

-
In-frameENST00000415930ENST00000442287GPIchr19

34884673

+POLGchr15

89876583

-
In-frameENST00000586425ENST00000268124GPIchr19

34884673

+POLGchr15

89876583

-
In-frameENST00000586425ENST00000442287GPIchr19

34884673

+POLGchr15

89876583

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000415930GPIchr1934884673+ENST00000268124POLGchr1589876583-487811121701138322
ENST00000415930GPIchr1934884673+ENST00000442287POLGchr1589876583-486111121701138322
ENST00000356487GPIchr1934884673+ENST00000268124POLGchr1589876583-491611501721176334
ENST00000356487GPIchr1934884673+ENST00000442287POLGchr1589876583-489911501721176334
ENST00000586425GPIchr1934884673+ENST00000268124POLGchr1589876583-470093425960311
ENST00000586425GPIchr1934884673+ENST00000442287POLGchr1589876583-468393425960311

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000415930ENST00000268124GPIchr1934884673+POLGchr1589876583-0.0105390180.989461
ENST00000415930ENST00000442287GPIchr1934884673+POLGchr1589876583-0.0105384890.9894615
ENST00000356487ENST00000268124GPIchr1934884673+POLGchr1589876583-0.0056795940.9943204
ENST00000356487ENST00000442287GPIchr1934884673+POLGchr1589876583-0.0057056880.99429435
ENST00000586425ENST00000268124GPIchr1934884673+POLGchr1589876583-0.0058979560.99410206
ENST00000586425ENST00000442287GPIchr1934884673+POLGchr1589876583-0.0059117970.9940882

Top

Fusion Genomic Features for GPI-POLG


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for GPI-POLG


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:34884673/chr15:89876583)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPI

PIGT

.
578FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGPIchr19:34884673chr15:89876583ENST00000356487+1118159_160303559.0RegionGlucose-6-phosphate binding
HgeneGPIchr19:34884673chr15:89876583ENST00000356487+1118210_215303559.0RegionGlucose-6-phosphate binding
HgeneGPIchr19:34884673chr15:89876583ENST00000415930+1118159_160314570.0RegionGlucose-6-phosphate binding
HgeneGPIchr19:34884673chr15:89876583ENST00000415930+1118210_215314570.0RegionGlucose-6-phosphate binding
TgenePOLGchr19:34884673chr15:89876583ENST0000026812402343_6001240.0Compositional biasNote=Poly-Gln
TgenePOLGchr19:34884673chr15:89876583ENST00000268124023535_53801240.0Compositional biasNote=Poly-Glu
TgenePOLGchr19:34884673chr15:89876583ENST0000044228702343_6001240.0Compositional biasNote=Poly-Gln
TgenePOLGchr19:34884673chr15:89876583ENST00000442287023535_53801240.0Compositional biasNote=Poly-Glu

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for GPI-POLG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>34298_34298_1_GPI-POLG_GPI_chr19_34884673_ENST00000356487_POLG_chr15_89876583_ENST00000268124_length(transcript)=4916nt_BP=1150nt
AGAGAGGAGCTGAGGCCCCAGATCAGCGGCCGCGGGCAAGGTCGCTCAGCGGGCACCCGGCCTGGGTATCGGGGCGCGGGTCGGGGGCGG
GGCCGGGGCTCAGGGGTGGGGCCGGGCCGGGCCGGGCCGGGCGCCTGCGCCATAAAGGCCGCCGCGCGCCCACGCGCCTCGCTTGCTGCG
CGCTGCCGGCGCTCCTTCCTCCTCGGCTCGCGTCTCACTCAGTGTACCTTCTAGTCCCGCCATGGCCGCTCTCACCCGGGACCCCCAGTT
CCAGAAGCTGCAGCAATGGTACCGCGAGCACCGCTCCGAGCTGAACCTGCGCCGCCTCTTCGATGCCAACAAGGACCGCTTCAACCACTT
CAGCTTGACCCTCAACACCAACCATGGGCATATCCTGGTGGATTACTCCAAGAACCTGGTGACGGAGGACGTGATGCGGATGCTGGTGGA
CTTGGCCAAGTCCAGGGGCGTGGAGGCCGCCCGGGAGCGGATGTTCAATGGTGAGAAGATCAACTACACCGAGGGTCGAGCCGTGCTGCA
CGTGGCTCTGCGGAACCGGTCAAACACACCCATCCTGGTAGACGGCAAGGATGTGATGCCAGAGGTCAACAAGGTTCTGGACAAGATGAA
GTCTTTCTGCCAGCGTGTCCGGAGCGGTGACTGGAAGGGGTACACAGGCAAGACCATCACGGACGTCATCAACATTGGCATTGGCGGCTC
CGACCTGGGACCCCTCATGGTGACTGAAGCCCTTAAGCCATACTCTTCAGGAGGTCCCCGCGTCTGGTATGTCTCCAACATTGATGGAAC
TCACATTGCCAAAACCCTGGCCCAGCTGAACCCCGAGTCCTCCCTGTTCATCATTGCCTCCAAGACCTTTACTACCCAGGAGACCATCAC
GAATGCAGAGACGGCGAAGGAGTGGTTTCTCCAGGCGGCCAAGGATCCTTCTGCAGTGGCGAAGCACTTTGTTGCCCTGTCTACTAACAC
AACCAAAGTGAAGGAGTTTGGAATTGACCCTCAAAACATGTTCGAGTTCTGGGATTGGGTGGGAGGACGCTACTCGCTGTGGTCGGCCAT
CGGACTCTCCATTGCCCTGCACGTGGGTTTTGACAACTTCGAGCAGCTGCTCTCGGGGGCTCACTGGATGGTGAAGCGCTGGATATTTAC
CAGATAATTGAACTCACCAAAGGCTCCTTGGAAAAACGAAGCCAGCCTGGACCATAGCACTGCCTGGAGGCTCTGTATTTGCTCCCGTGG
AGCTTCATCGGGGTGGTGCAGGCTCCCAAACTCAGGCTTTCAGCTGTGCTTTTTGCAAAAGGGCTTGCCTAAGGCCAGCCATTTTTCAGT
AGCAGGACCTGCCAAGAAGATTCCTTCTAACTGAAGGTGCAGTTGAATTCAGTGGGTTCAGAACCAAGATGCCAACATCGGTGTGGACTA
CAGGACAAGGGGCATTGTTGCTTGTTGGGTAAAAATGAAGCAGAAGCCCCAAAGTTCACATTAACTCAGGCATTTCATTTATTTTTTCCT
TTTCTTCTTGGCTGGTTCTTTGTTCTGTCCCCCATGCTCTGATGCAGTGCCCTAGAAGGGGAAAGAATTAATGCTCTAACGTGATAAACC
TGCTCCAAGGCAGTGGAAATAAAAAGAAGGAAAAAAAAGACTCTATCTTCTCATCGTGCATGTTTGCCTACAAGCTGGGTCTGAATGACT
TGCCCCAGTCAGTCGCCTTTTTCAGTGCAGTCGATATTGACCGGTGCCTCAGGAAGGAAGTGACCATGGATTGTAAAACCCCTTCCAACC
CAACTGGGATGGAAAGGAGATACGGGATTCCCCAGGTTTATGACCAGCCGTGTGAATTGGGTGGTACAGAGCTCTGCTGTTGACTACTTA
CACCTCATGCTTGTGGCCATGAAGTGGCTGTTTGAAGAGTTTGCCATAGATGGGCGCTTCTGCATCAGCATCCATGACGAGGTTCGCTAC
CTGGTGCGGGAGGAGGACCGCTACCGCGCTGCCCTGGCCTTGCAGATCACCAACCTCTTGACCAGGTCACAGTGGAAGAAGTGGGAGGTG
GTTGCTGAACGGGCATGGAAGGGGGGCACAGAGTCAGAAATGTTCAATAAGCTTGAGAGCATTGCTACGTCTGACATACCACGTACCCCG
GTGCTGGGCTGCTGCATCAGCCGAGCCCTGGAGCCCTCGGCTGTCCAGGAAGAGGTATCGGCTGTCGGATGAGGGCGAGTGGCTGGTGAG
GGAGTTGAACCTCCCAGTGGACAGGACTGAGGGTGGCTGGATTTCCCTGCAGGATCTGCGCAAGGTCCAGAGAGAAACTGCAAGGAAGCT
GCACAGCCTTTGGGTGGATGACACTGCAGGGCAGGAAGAGCAGGGGCACTGATCTACACAGTAAGACAGCCACTACTGTGGGCATCAGCC
GTGAGCATGCCAAAATCTTCAACTACGGCCGCATCTATGGTGCTGGGCAGCCCTTTGCTGAGCGCTTACTAATGCAGTTTAACCACCGGC
TCACACAGCAGGAGGCAGCTGAGAAGGCCCAGCAGATGTACGCTGCCACCAAGGGCCTCCGCTGCCTGACCGAGTAGGCAGTGAGTTGAA
AGCCATGGTGCAGGCCCCACCTGGCTACACCCTTGTGGGTGCTGATGTGGACTCCCAAGAGCTGTGGATTGCAGCTGTGCTTGGAGACGC
CCACTTTGCCGGCATGCATGGCACCCCGACTATGATGAGGAAGGCCTCTATGGGGCCATCCTGCCCCAAGTGGTGACTGCCGGCACCATC
ACTCGCCGGGCTGTGGAGCCCACATGGCTCACCGCCAGCAATGCCCGGCTCCCAGATGGTGGTGTGGCTGCCCAGGTCAGCTCTGCCCCG
TGCTGTGATCAGGATGGTAATAGCTGTAATGTGGGAAGCCCCTTTGCCAAGGACTTCCTGCCCAAGATGGAGGATGGCACCCTGCAGGCT
GGCCCAGGAGGTGCCAGTGGGCCCCGTGCTCTGGAAATCAACAAAATGATTTCTTTCTGGAGGAACGCCCATAAACGTATCAGACTGCCC
GTGGTGGCCCCAAGGACACCCAGCCCAGCTATCACCATGGCAATGGACCTTACAACGACGTGGACATCCCTGGCTGCTGGTTTTTCAAGC
TGCCTCACAAGGTAGAAGAACTGGATTACTTAGAAGTGGAGGCTGAGGCCAAGATGGAGAACTTGCGAGCTGCAGTGCCAGGTCAACCCC
TAGCTCTGAGCCATCGAGTCCCTGTACAGGAAGCACTGTCTCGAACAGGGGAAGCAGCAGCTGATGCCCCAGGAGGCCGGCCTGGCGGAG
GAGTTCCTGCTCACTGACAATAGTGCCATATGGCAAACGATGGTACCGGAAGCTCTGCCCCCGGCTAGACGACCCTGCATGGACCCCGGG
CCCCAGCCTCCTCAGCCTGCAGATGCGGGTCACACCTAAACTCATGGCACTTACCTGGGATGGCTTCCCTCTGCACTACTCAGAGCGTCA
TGGCTGGGGCTACTTGGTGCCTGGGCGGCGGGACAACCTGGCCAAGCTGCCGACAGGTACCACCCTGGAGTCAGCTGGGGTGGTCTGCCC
CTACAGACCTCGGCCCCTGCAGTGAGGAGGAGGAGTTTCAACAAGATGTCATGGCCCGCGCCTGCTTGCAGAAGCTGAAGGGGACCACAG
AGCTCCTGCCCAAGCGGCCCCAGCACCTTCCTGGACACCCTGGGTACAAAGAAGACCCCTGGCTCTGGGACCTGGAGTGGGACCTGCAAG
AATTTAAGCAGAAGAAAGCTAAGAAGGTGAAGAAGGAACCAGCCACAGCCAGCAAGTTGCCCATCGAGGGGGCTGGGGCCCCTGGTGATC
CCATGGATCAGGAAGGTGTCCCCACCCAGTGACTCTGGCCGGCATGCTGGAGATGGGTGTCTCCTACCTGCCTGTCAACCAGAACTGGGA
GCGTTACCTGGCAGAGGCACAGGGCACTTATGAGGAGCTCCAGCGGGAGATGAAGAAGTCGTTGATGGATCTGGCCAATGATGCCTGCCA
GCTGCTCTCAGGAGAGAGGACCTGATGCAGTACTGTGCCCAGGACGTGTGGGCCACCCATGAGGTTTTCCAGCAGCAGCTACCGCTCTTC
TTGGAGAGATCTCATCCTGGGACTGGCTGGACATCAGCAGTGTCAACAGTCTGGCAGAGGTGCACAGACTTTATGTAGGGGGGCCTCCCT
TAGAGAAGGAGCCTCGAGAACTGTTTGTGAAGGGCACCATGAAGGACATTCGTGAGAACTTCCAGGGTTCCCGCATGCGTTTCCTGGACA
CCATGAGCATGCACATGGCCATCTCAGGGCTAAGCAGCTTCCAGCGCAGTCTGTGGATAGCAGCCAAGCAGGGCAAACACAAGGTCCAGC
CCCCCACAAAGCAAGGCCAGAAGTCCCAGAGGAAAGCCAGAAGAGGCCCAGCGGTATTCCTGGTGCAGCCAGCGGCTGGTGGAAGAGCGT
TACTCTTGGACCAGCCAGCTGTCGCCGGCTGACCTCATCCCCCTGGAGGTCCCTACTGGTGCCAGCAGCCCCACCCAGAGAGACTGGCAG
GAGCAGTTAGTGGTGGGGCACAATGTTTCCTTTGACCGAGCTCATATCAGGGAGCAGTACCTGATCCAGCTGGACCAGCACTTCCGCCTC
CTGGCCCAGAAGCAGAGCCTGCCCTACCTGGAGGCGGCCAACTTGCTGTTGCAGGCCCAGCTGCCCCCGAAGCCCCCGGCTTGGGCCTGG
GCGGAGGGCTGGACCCGGTACGGCCCCGAGGGGGAGGCCGTACCCGTGGCCATCCCCGAGGAGCGGGCCCTGGTGTTCGACGTGGAGGTC

>34298_34298_1_GPI-POLG_GPI_chr19_34884673_ENST00000356487_POLG_chr15_89876583_ENST00000268124_length(amino acids)=334AA_BP=
MLRAAGAPSSSARVSLSVPSSPAMAALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHILVDYSKNLVTEDVMRM
LVDLAKSRGVEAARERMFNGEKINYTEGRAVLHVALRNRSNTPILVDGKDVMPEVNKVLDKMKSFCQRVRSGDWKGYTGKTITDVINIGI
GGSDLGPLMVTEALKPYSSGGPRVWYVSNIDGTHIAKTLAQLNPESSLFIIASKTFTTQETITNAETAKEWFLQAAKDPSAVAKHFVALS

--------------------------------------------------------------
>34298_34298_2_GPI-POLG_GPI_chr19_34884673_ENST00000356487_POLG_chr15_89876583_ENST00000442287_length(transcript)=4899nt_BP=1150nt
AGAGAGGAGCTGAGGCCCCAGATCAGCGGCCGCGGGCAAGGTCGCTCAGCGGGCACCCGGCCTGGGTATCGGGGCGCGGGTCGGGGGCGG
GGCCGGGGCTCAGGGGTGGGGCCGGGCCGGGCCGGGCCGGGCGCCTGCGCCATAAAGGCCGCCGCGCGCCCACGCGCCTCGCTTGCTGCG
CGCTGCCGGCGCTCCTTCCTCCTCGGCTCGCGTCTCACTCAGTGTACCTTCTAGTCCCGCCATGGCCGCTCTCACCCGGGACCCCCAGTT
CCAGAAGCTGCAGCAATGGTACCGCGAGCACCGCTCCGAGCTGAACCTGCGCCGCCTCTTCGATGCCAACAAGGACCGCTTCAACCACTT
CAGCTTGACCCTCAACACCAACCATGGGCATATCCTGGTGGATTACTCCAAGAACCTGGTGACGGAGGACGTGATGCGGATGCTGGTGGA
CTTGGCCAAGTCCAGGGGCGTGGAGGCCGCCCGGGAGCGGATGTTCAATGGTGAGAAGATCAACTACACCGAGGGTCGAGCCGTGCTGCA
CGTGGCTCTGCGGAACCGGTCAAACACACCCATCCTGGTAGACGGCAAGGATGTGATGCCAGAGGTCAACAAGGTTCTGGACAAGATGAA
GTCTTTCTGCCAGCGTGTCCGGAGCGGTGACTGGAAGGGGTACACAGGCAAGACCATCACGGACGTCATCAACATTGGCATTGGCGGCTC
CGACCTGGGACCCCTCATGGTGACTGAAGCCCTTAAGCCATACTCTTCAGGAGGTCCCCGCGTCTGGTATGTCTCCAACATTGATGGAAC
TCACATTGCCAAAACCCTGGCCCAGCTGAACCCCGAGTCCTCCCTGTTCATCATTGCCTCCAAGACCTTTACTACCCAGGAGACCATCAC
GAATGCAGAGACGGCGAAGGAGTGGTTTCTCCAGGCGGCCAAGGATCCTTCTGCAGTGGCGAAGCACTTTGTTGCCCTGTCTACTAACAC
AACCAAAGTGAAGGAGTTTGGAATTGACCCTCAAAACATGTTCGAGTTCTGGGATTGGGTGGGAGGACGCTACTCGCTGTGGTCGGCCAT
CGGACTCTCCATTGCCCTGCACGTGGGTTTTGACAACTTCGAGCAGCTGCTCTCGGGGGCTCACTGGATGGTGAAGCGCTGGATATTTAC
CAGATAATTGAACTCACCAAAGGCTCCTTGGAAAAACGAAGCCAGCCTGGACCATAGCACTGCCTGGAGGCTCTGTATTTGCTCCCGTGG
AGCTTCATCGGGGTGGTGCAGGCTCCCAAACTCAGGCTTTCAGCTGTGCTTTTTGCAAAAGGGCTTGCCTAAGGCCAGCCATTTTTCAGT
AGCAGGACCTGCCAAGAAGATTCCTTCTAACTGAAGGTGCAGTTGAATTCAGTGGGTTCAGAACCAAGATGCCAACATCGGTGTGGACTA
CAGGACAAGGGGCATTGTTGCTTGTTGGGTAAAAATGAAGCAGAAGCCCCAAAGTTCACATTAACTCAGGCATTTCATTTATTTTTTCCT
TTTCTTCTTGGCTGGTTCTTTGTTCTGTCCCCCATGCTCTGATGCAGTGCCCTAGAAGGGGAAAGAATTAATGCTCTAACGTGATAAACC
TGCTCCAAGGCAGTGGAAATAAAAAGAAGGAAAAAAAAGTGCATGTTTGCCTACAAGCTGGGTCTGAATGACTTGCCCCAGTCAGTCGCC
TTTTTCAGTGCAGTCGATATTGACCGGTGCCTCAGGAAGGAAGTGACCATGGATTGTAAAACCCCTTCCAACCCAACTGGGATGGAAAGG
AGATACGGGATTCCCCAGGTTTATGACCAGCCGTGTGAATTGGGTGGTACAGAGCTCTGCTGTTGACTACTTACACCTCATGCTTGTGGC
CATGAAGTGGCTGTTTGAAGAGTTTGCCATAGATGGGCGCTTCTGCATCAGCATCCATGACGAGGTTCGCTACCTGGTGCGGGAGGAGGA
CCGCTACCGCGCTGCCCTGGCCTTGCAGATCACCAACCTCTTGACCAGGTCACAGTGGAAGAAGTGGGAGGTGGTTGCTGAACGGGCATG
GAAGGGGGGCACAGAGTCAGAAATGTTCAATAAGCTTGAGAGCATTGCTACGTCTGACATACCACGTACCCCGGTGCTGGGCTGCTGCAT
CAGCCGAGCCCTGGAGCCCTCGGCTGTCCAGGAAGAGGTATCGGCTGTCGGATGAGGGCGAGTGGCTGGTGAGGGAGTTGAACCTCCCAG
TGGACAGGACTGAGGGTGGCTGGATTTCCCTGCAGGATCTGCGCAAGGTCCAGAGAGAAACTGCAAGGAAGCTGCACAGCCTTTGGGTGG
ATGACACTGCAGGGCAGGAAGAGCAGGGGCACTGATCTACACAGTAAGACAGCCACTACTGTGGGCATCAGCCGTGAGCATGCCAAAATC
TTCAACTACGGCCGCATCTATGGTGCTGGGCAGCCCTTTGCTGAGCGCTTACTAATGCAGTTTAACCACCGGCTCACACAGCAGGAGGCA
GCTGAGAAGGCCCAGCAGATGTACGCTGCCACCAAGGGCCTCCGCTGCCTGACCGAGTAGGCAGTGAGTTGAAAGCCATGGTGCAGGCCC
CACCTGGCTACACCCTTGTGGGTGCTGATGTGGACTCCCAAGAGCTGTGGATTGCAGCTGTGCTTGGAGACGCCCACTTTGCCGGCATGC
ATGGCACCCCGACTATGATGAGGAAGGCCTCTATGGGGCCATCCTGCCCCAAGTGGTGACTGCCGGCACCATCACTCGCCGGGCTGTGGA
GCCCACATGGCTCACCGCCAGCAATGCCCGGCTCCCAGATGGTGGTGTGGCTGCCCAGGTCAGCTCTGCCCCGTGCTGTGATCAGGATGG
TAATAGCTGTAATGTGGGAAGCCCCTTTGCCAAGGACTTCCTGCCCAAGATGGAGGATGGCACCCTGCAGGCTGGCCCAGGAGGTGCCAG
TGGGCCCCGTGCTCTGGAAATCAACAAAATGATTTCTTTCTGGAGGAACGCCCATAAACGTATCAGACTGCCCGTGGTGGCCCCAAGGAC
ACCCAGCCCAGCTATCACCATGGCAATGGACCTTACAACGACGTGGACATCCCTGGCTGCTGGTTTTTCAAGCTGCCTCACAAGGTAGAA
GAACTGGATTACTTAGAAGTGGAGGCTGAGGCCAAGATGGAGAACTTGCGAGCTGCAGTGCCAGGTCAACCCCTAGCTCTGAGCCATCGA
GTCCCTGTACAGGAAGCACTGTCTCGAACAGGGGAAGCAGCAGCTGATGCCCCAGGAGGCCGGCCTGGCGGAGGAGTTCCTGCTCACTGA
CAATAGTGCCATATGGCAAACGATGGTACCGGAAGCTCTGCCCCCGGCTAGACGACCCTGCATGGACCCCGGGCCCCAGCCTCCTCAGCC
TGCAGATGCGGGTCACACCTAAACTCATGGCACTTACCTGGGATGGCTTCCCTCTGCACTACTCAGAGCGTCATGGCTGGGGCTACTTGG
TGCCTGGGCGGCGGGACAACCTGGCCAAGCTGCCGACAGGTACCACCCTGGAGTCAGCTGGGGTGGTCTGCCCCTACAGACCTCGGCCCC
TGCAGTGAGGAGGAGGAGTTTCAACAAGATGTCATGGCCCGCGCCTGCTTGCAGAAGCTGAAGGGGACCACAGAGCTCCTGCCCAAGCGG
CCCCAGCACCTTCCTGGACACCCTGGGTACAAAGAAGACCCCTGGCTCTGGGACCTGGAGTGGGACCTGCAAGAATTTAAGCAGAAGAAA
GCTAAGAAGGTGAAGAAGGAACCAGCCACAGCCAGCAAGTTGCCCATCGAGGGGGCTGGGGCCCCTGGTGATCCCATGGATCAGGAAGGT
GTCCCCACCCAGTGACTCTGGCCGGCATGCTGGAGATGGGTGTCTCCTACCTGCCTGTCAACCAGAACTGGGAGCGTTACCTGGCAGAGG
CACAGGGCACTTATGAGGAGCTCCAGCGGGAGATGAAGAAGTCGTTGATGGATCTGGCCAATGATGCCTGCCAGCTGCTCTCAGGAGAGA
GGACCTGATGCAGTACTGTGCCCAGGACGTGTGGGCCACCCATGAGGTTTTCCAGCAGCAGCTACCGCTCTTCTTGGAGAGATCTCATCC
TGGGACTGGCTGGACATCAGCAGTGTCAACAGTCTGGCAGAGGTGCACAGACTTTATGTAGGGGGGCCTCCCTTAGAGAAGGAGCCTCGA
GAACTGTTTGTGAAGGGCACCATGAAGGACATTCGTGAGAACTTCCAGGGTTCCCGCATGCGTTTCCTGGACACCATGAGCATGCACATG
GCCATCTCAGGGCTAAGCAGCTTCCAGCGCAGTCTGTGGATAGCAGCCAAGCAGGGCAAACACAAGGTCCAGCCCCCCACAAAGCAAGGC
CAGAAGTCCCAGAGGAAAGCCAGAAGAGGCCCAGCGGTATTCCTGGTGCAGCCAGCGGCTGGTGGAAGAGCGTTACTCTTGGACCAGCCA
GCTGTCGCCGGCTGACCTCATCCCCCTGGAGGTCCCTACTGGTGCCAGCAGCCCCACCCAGAGAGACTGGCAGGAGCAGTTAGTGGTGGG
GCACAATGTTTCCTTTGACCGAGCTCATATCAGGGAGCAGTACCTGATCCAGCTGGACCAGCACTTCCGCCTCCTGGCCCAGAAGCAGAG
CCTGCCCTACCTGGAGGCGGCCAACTTGCTGTTGCAGGCCCAGCTGCCCCCGAAGCCCCCGGCTTGGGCCTGGGCGGAGGGCTGGACCCG
GTACGGCCCCGAGGGGGAGGCCGTACCCGTGGCCATCCCCGAGGAGCGGGCCCTGGTGTTCGACGTGGAGGTCTGCTTGGCAGAGGGAAC

>34298_34298_2_GPI-POLG_GPI_chr19_34884673_ENST00000356487_POLG_chr15_89876583_ENST00000442287_length(amino acids)=334AA_BP=
MLRAAGAPSSSARVSLSVPSSPAMAALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHILVDYSKNLVTEDVMRM
LVDLAKSRGVEAARERMFNGEKINYTEGRAVLHVALRNRSNTPILVDGKDVMPEVNKVLDKMKSFCQRVRSGDWKGYTGKTITDVINIGI
GGSDLGPLMVTEALKPYSSGGPRVWYVSNIDGTHIAKTLAQLNPESSLFIIASKTFTTQETITNAETAKEWFLQAAKDPSAVAKHFVALS

--------------------------------------------------------------
>34298_34298_3_GPI-POLG_GPI_chr19_34884673_ENST00000415930_POLG_chr15_89876583_ENST00000268124_length(transcript)=4878nt_BP=1112nt
AATAGCCCTTACCACCAGCAGACACACATCATCTGTTGTACTTGCTTATTTGGCACATATGTATCCACAGCGCCTAGAACACTGCCTGTA
ACGTGGAAGGTGTTCGATCTATAGAGTTTTGTCGAATGAATGAATGAAGCCGACTAGTGCACAGGGAGTGCAGCGGCGCGATGGTAGCTC
TCTGCAGCCTCCAACACCTGGGCTCCAGTGATCCCCGGGCTCTGCCCACCCTCCCCACTGCCACTTCCGGGCAGAGGCCAGCAAAGCGGC
GGCGCAAGAGTCCCGCCATGGCCGCTCTCACCCGGGACCCCCAGTTCCAGAAGCTGCAGCAATGGTACCGCGAGCACCGCTCCGAGCTGA
ACCTGCGCCGCCTCTTCGATGCCAACAAGGACCGCTTCAACCACTTCAGCTTGACCCTCAACACCAACCATGGGCATATCCTGGTGGATT
ACTCCAAGAACCTGGTGACGGAGGACGTGATGCGGATGCTGGTGGACTTGGCCAAGTCCAGGGGCGTGGAGGCCGCCCGGGAGCGGATGT
TCAATGGTGAGAAGATCAACTACACCGAGGGTCGAGCCGTGCTGCACGTGGCTCTGCGGAACCGGTCAAACACACCCATCCTGGTAGACG
GCAAGGATGTGATGCCAGAGGTCAACAAGGTTCTGGACAAGATGAAGTCTTTCTGCCAGGGACCCCTCATGGTGACTGAAGCCCTTAAGC
CATACTCTTCAGGAGGTCCCCGCGTCTGGTATGTCTCCAACATTGATGGAACTCACATTGCCAAAACCCTGGCCCAGCTGAACCCCGAGT
CCTCCCTGTTCATCATTGCCTCCAAGACCTTTACTACCCAGGAGACCATCACGAATGCAGAGACGGCGAAGGAGTGGTTTCTCCAGGCGG
CCAAGGATCCTTCTGCAGTGGCGAAGCACTTTGTTGCCCTGTCTACTAACACAACCAAAGTGAAGGAGTTTGGAATTGACCCTCAAAACA
TGTTCGAGTTCTGGGATTGGGTGGGAGGACGCTACTCGCTGTGGTCGGCCATCGGACTCTCCATTGCCCTGCACGTGGGTTTTGACAACT
TCGAGCAGCTGCTCTCGGGGGCTCACTGGATGGTGAAGCGCTGGATATTTACCAGATAATTGAACTCACCAAAGGCTCCTTGGAAAAACG
AAGCCAGCCTGGACCATAGCACTGCCTGGAGGCTCTGTATTTGCTCCCGTGGAGCTTCATCGGGGTGGTGCAGGCTCCCAAACTCAGGCT
TTCAGCTGTGCTTTTTGCAAAAGGGCTTGCCTAAGGCCAGCCATTTTTCAGTAGCAGGACCTGCCAAGAAGATTCCTTCTAACTGAAGGT
GCAGTTGAATTCAGTGGGTTCAGAACCAAGATGCCAACATCGGTGTGGACTACAGGACAAGGGGCATTGTTGCTTGTTGGGTAAAAATGA
AGCAGAAGCCCCAAAGTTCACATTAACTCAGGCATTTCATTTATTTTTTCCTTTTCTTCTTGGCTGGTTCTTTGTTCTGTCCCCCATGCT
CTGATGCAGTGCCCTAGAAGGGGAAAGAATTAATGCTCTAACGTGATAAACCTGCTCCAAGGCAGTGGAAATAAAAAGAAGGAAAAAAAA
GACTCTATCTTCTCATCGTGCATGTTTGCCTACAAGCTGGGTCTGAATGACTTGCCCCAGTCAGTCGCCTTTTTCAGTGCAGTCGATATT
GACCGGTGCCTCAGGAAGGAAGTGACCATGGATTGTAAAACCCCTTCCAACCCAACTGGGATGGAAAGGAGATACGGGATTCCCCAGGTT
TATGACCAGCCGTGTGAATTGGGTGGTACAGAGCTCTGCTGTTGACTACTTACACCTCATGCTTGTGGCCATGAAGTGGCTGTTTGAAGA
GTTTGCCATAGATGGGCGCTTCTGCATCAGCATCCATGACGAGGTTCGCTACCTGGTGCGGGAGGAGGACCGCTACCGCGCTGCCCTGGC
CTTGCAGATCACCAACCTCTTGACCAGGTCACAGTGGAAGAAGTGGGAGGTGGTTGCTGAACGGGCATGGAAGGGGGGCACAGAGTCAGA
AATGTTCAATAAGCTTGAGAGCATTGCTACGTCTGACATACCACGTACCCCGGTGCTGGGCTGCTGCATCAGCCGAGCCCTGGAGCCCTC
GGCTGTCCAGGAAGAGGTATCGGCTGTCGGATGAGGGCGAGTGGCTGGTGAGGGAGTTGAACCTCCCAGTGGACAGGACTGAGGGTGGCT
GGATTTCCCTGCAGGATCTGCGCAAGGTCCAGAGAGAAACTGCAAGGAAGCTGCACAGCCTTTGGGTGGATGACACTGCAGGGCAGGAAG
AGCAGGGGCACTGATCTACACAGTAAGACAGCCACTACTGTGGGCATCAGCCGTGAGCATGCCAAAATCTTCAACTACGGCCGCATCTAT
GGTGCTGGGCAGCCCTTTGCTGAGCGCTTACTAATGCAGTTTAACCACCGGCTCACACAGCAGGAGGCAGCTGAGAAGGCCCAGCAGATG
TACGCTGCCACCAAGGGCCTCCGCTGCCTGACCGAGTAGGCAGTGAGTTGAAAGCCATGGTGCAGGCCCCACCTGGCTACACCCTTGTGG
GTGCTGATGTGGACTCCCAAGAGCTGTGGATTGCAGCTGTGCTTGGAGACGCCCACTTTGCCGGCATGCATGGCACCCCGACTATGATGA
GGAAGGCCTCTATGGGGCCATCCTGCCCCAAGTGGTGACTGCCGGCACCATCACTCGCCGGGCTGTGGAGCCCACATGGCTCACCGCCAG
CAATGCCCGGCTCCCAGATGGTGGTGTGGCTGCCCAGGTCAGCTCTGCCCCGTGCTGTGATCAGGATGGTAATAGCTGTAATGTGGGAAG
CCCCTTTGCCAAGGACTTCCTGCCCAAGATGGAGGATGGCACCCTGCAGGCTGGCCCAGGAGGTGCCAGTGGGCCCCGTGCTCTGGAAAT
CAACAAAATGATTTCTTTCTGGAGGAACGCCCATAAACGTATCAGACTGCCCGTGGTGGCCCCAAGGACACCCAGCCCAGCTATCACCAT
GGCAATGGACCTTACAACGACGTGGACATCCCTGGCTGCTGGTTTTTCAAGCTGCCTCACAAGGTAGAAGAACTGGATTACTTAGAAGTG
GAGGCTGAGGCCAAGATGGAGAACTTGCGAGCTGCAGTGCCAGGTCAACCCCTAGCTCTGAGCCATCGAGTCCCTGTACAGGAAGCACTG
TCTCGAACAGGGGAAGCAGCAGCTGATGCCCCAGGAGGCCGGCCTGGCGGAGGAGTTCCTGCTCACTGACAATAGTGCCATATGGCAAAC
GATGGTACCGGAAGCTCTGCCCCCGGCTAGACGACCCTGCATGGACCCCGGGCCCCAGCCTCCTCAGCCTGCAGATGCGGGTCACACCTA
AACTCATGGCACTTACCTGGGATGGCTTCCCTCTGCACTACTCAGAGCGTCATGGCTGGGGCTACTTGGTGCCTGGGCGGCGGGACAACC
TGGCCAAGCTGCCGACAGGTACCACCCTGGAGTCAGCTGGGGTGGTCTGCCCCTACAGACCTCGGCCCCTGCAGTGAGGAGGAGGAGTTT
CAACAAGATGTCATGGCCCGCGCCTGCTTGCAGAAGCTGAAGGGGACCACAGAGCTCCTGCCCAAGCGGCCCCAGCACCTTCCTGGACAC
CCTGGGTACAAAGAAGACCCCTGGCTCTGGGACCTGGAGTGGGACCTGCAAGAATTTAAGCAGAAGAAAGCTAAGAAGGTGAAGAAGGAA
CCAGCCACAGCCAGCAAGTTGCCCATCGAGGGGGCTGGGGCCCCTGGTGATCCCATGGATCAGGAAGGTGTCCCCACCCAGTGACTCTGG
CCGGCATGCTGGAGATGGGTGTCTCCTACCTGCCTGTCAACCAGAACTGGGAGCGTTACCTGGCAGAGGCACAGGGCACTTATGAGGAGC
TCCAGCGGGAGATGAAGAAGTCGTTGATGGATCTGGCCAATGATGCCTGCCAGCTGCTCTCAGGAGAGAGGACCTGATGCAGTACTGTGC
CCAGGACGTGTGGGCCACCCATGAGGTTTTCCAGCAGCAGCTACCGCTCTTCTTGGAGAGATCTCATCCTGGGACTGGCTGGACATCAGC
AGTGTCAACAGTCTGGCAGAGGTGCACAGACTTTATGTAGGGGGGCCTCCCTTAGAGAAGGAGCCTCGAGAACTGTTTGTGAAGGGCACC
ATGAAGGACATTCGTGAGAACTTCCAGGGTTCCCGCATGCGTTTCCTGGACACCATGAGCATGCACATGGCCATCTCAGGGCTAAGCAGC
TTCCAGCGCAGTCTGTGGATAGCAGCCAAGCAGGGCAAACACAAGGTCCAGCCCCCCACAAAGCAAGGCCAGAAGTCCCAGAGGAAAGCC
AGAAGAGGCCCAGCGGTATTCCTGGTGCAGCCAGCGGCTGGTGGAAGAGCGTTACTCTTGGACCAGCCAGCTGTCGCCGGCTGACCTCAT
CCCCCTGGAGGTCCCTACTGGTGCCAGCAGCCCCACCCAGAGAGACTGGCAGGAGCAGTTAGTGGTGGGGCACAATGTTTCCTTTGACCG
AGCTCATATCAGGGAGCAGTACCTGATCCAGCTGGACCAGCACTTCCGCCTCCTGGCCCAGAAGCAGAGCCTGCCCTACCTGGAGGCGGC
CAACTTGCTGTTGCAGGCCCAGCTGCCCCCGAAGCCCCCGGCTTGGGCCTGGGCGGAGGGCTGGACCCGGTACGGCCCCGAGGGGGAGGC
CGTACCCGTGGCCATCCCCGAGGAGCGGGCCCTGGTGTTCGACGTGGAGGTCTGCTTGGCAGAGGGAACTTGCCCCACATTGGCGGTGGC

>34298_34298_3_GPI-POLG_GPI_chr19_34884673_ENST00000415930_POLG_chr15_89876583_ENST00000268124_length(amino acids)=322AA_BP=
MVALCSLQHLGSSDPRALPTLPTATSGQRPAKRRRKSPAMAALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHI
LVDYSKNLVTEDVMRMLVDLAKSRGVEAARERMFNGEKINYTEGRAVLHVALRNRSNTPILVDGKDVMPEVNKVLDKMKSFCQGPLMVTE
ALKPYSSGGPRVWYVSNIDGTHIAKTLAQLNPESSLFIIASKTFTTQETITNAETAKEWFLQAAKDPSAVAKHFVALSTNTTKVKEFGID

--------------------------------------------------------------
>34298_34298_4_GPI-POLG_GPI_chr19_34884673_ENST00000415930_POLG_chr15_89876583_ENST00000442287_length(transcript)=4861nt_BP=1112nt
AATAGCCCTTACCACCAGCAGACACACATCATCTGTTGTACTTGCTTATTTGGCACATATGTATCCACAGCGCCTAGAACACTGCCTGTA
ACGTGGAAGGTGTTCGATCTATAGAGTTTTGTCGAATGAATGAATGAAGCCGACTAGTGCACAGGGAGTGCAGCGGCGCGATGGTAGCTC
TCTGCAGCCTCCAACACCTGGGCTCCAGTGATCCCCGGGCTCTGCCCACCCTCCCCACTGCCACTTCCGGGCAGAGGCCAGCAAAGCGGC
GGCGCAAGAGTCCCGCCATGGCCGCTCTCACCCGGGACCCCCAGTTCCAGAAGCTGCAGCAATGGTACCGCGAGCACCGCTCCGAGCTGA
ACCTGCGCCGCCTCTTCGATGCCAACAAGGACCGCTTCAACCACTTCAGCTTGACCCTCAACACCAACCATGGGCATATCCTGGTGGATT
ACTCCAAGAACCTGGTGACGGAGGACGTGATGCGGATGCTGGTGGACTTGGCCAAGTCCAGGGGCGTGGAGGCCGCCCGGGAGCGGATGT
TCAATGGTGAGAAGATCAACTACACCGAGGGTCGAGCCGTGCTGCACGTGGCTCTGCGGAACCGGTCAAACACACCCATCCTGGTAGACG
GCAAGGATGTGATGCCAGAGGTCAACAAGGTTCTGGACAAGATGAAGTCTTTCTGCCAGGGACCCCTCATGGTGACTGAAGCCCTTAAGC
CATACTCTTCAGGAGGTCCCCGCGTCTGGTATGTCTCCAACATTGATGGAACTCACATTGCCAAAACCCTGGCCCAGCTGAACCCCGAGT
CCTCCCTGTTCATCATTGCCTCCAAGACCTTTACTACCCAGGAGACCATCACGAATGCAGAGACGGCGAAGGAGTGGTTTCTCCAGGCGG
CCAAGGATCCTTCTGCAGTGGCGAAGCACTTTGTTGCCCTGTCTACTAACACAACCAAAGTGAAGGAGTTTGGAATTGACCCTCAAAACA
TGTTCGAGTTCTGGGATTGGGTGGGAGGACGCTACTCGCTGTGGTCGGCCATCGGACTCTCCATTGCCCTGCACGTGGGTTTTGACAACT
TCGAGCAGCTGCTCTCGGGGGCTCACTGGATGGTGAAGCGCTGGATATTTACCAGATAATTGAACTCACCAAAGGCTCCTTGGAAAAACG
AAGCCAGCCTGGACCATAGCACTGCCTGGAGGCTCTGTATTTGCTCCCGTGGAGCTTCATCGGGGTGGTGCAGGCTCCCAAACTCAGGCT
TTCAGCTGTGCTTTTTGCAAAAGGGCTTGCCTAAGGCCAGCCATTTTTCAGTAGCAGGACCTGCCAAGAAGATTCCTTCTAACTGAAGGT
GCAGTTGAATTCAGTGGGTTCAGAACCAAGATGCCAACATCGGTGTGGACTACAGGACAAGGGGCATTGTTGCTTGTTGGGTAAAAATGA
AGCAGAAGCCCCAAAGTTCACATTAACTCAGGCATTTCATTTATTTTTTCCTTTTCTTCTTGGCTGGTTCTTTGTTCTGTCCCCCATGCT
CTGATGCAGTGCCCTAGAAGGGGAAAGAATTAATGCTCTAACGTGATAAACCTGCTCCAAGGCAGTGGAAATAAAAAGAAGGAAAAAAAA
GTGCATGTTTGCCTACAAGCTGGGTCTGAATGACTTGCCCCAGTCAGTCGCCTTTTTCAGTGCAGTCGATATTGACCGGTGCCTCAGGAA
GGAAGTGACCATGGATTGTAAAACCCCTTCCAACCCAACTGGGATGGAAAGGAGATACGGGATTCCCCAGGTTTATGACCAGCCGTGTGA
ATTGGGTGGTACAGAGCTCTGCTGTTGACTACTTACACCTCATGCTTGTGGCCATGAAGTGGCTGTTTGAAGAGTTTGCCATAGATGGGC
GCTTCTGCATCAGCATCCATGACGAGGTTCGCTACCTGGTGCGGGAGGAGGACCGCTACCGCGCTGCCCTGGCCTTGCAGATCACCAACC
TCTTGACCAGGTCACAGTGGAAGAAGTGGGAGGTGGTTGCTGAACGGGCATGGAAGGGGGGCACAGAGTCAGAAATGTTCAATAAGCTTG
AGAGCATTGCTACGTCTGACATACCACGTACCCCGGTGCTGGGCTGCTGCATCAGCCGAGCCCTGGAGCCCTCGGCTGTCCAGGAAGAGG
TATCGGCTGTCGGATGAGGGCGAGTGGCTGGTGAGGGAGTTGAACCTCCCAGTGGACAGGACTGAGGGTGGCTGGATTTCCCTGCAGGAT
CTGCGCAAGGTCCAGAGAGAAACTGCAAGGAAGCTGCACAGCCTTTGGGTGGATGACACTGCAGGGCAGGAAGAGCAGGGGCACTGATCT
ACACAGTAAGACAGCCACTACTGTGGGCATCAGCCGTGAGCATGCCAAAATCTTCAACTACGGCCGCATCTATGGTGCTGGGCAGCCCTT
TGCTGAGCGCTTACTAATGCAGTTTAACCACCGGCTCACACAGCAGGAGGCAGCTGAGAAGGCCCAGCAGATGTACGCTGCCACCAAGGG
CCTCCGCTGCCTGACCGAGTAGGCAGTGAGTTGAAAGCCATGGTGCAGGCCCCACCTGGCTACACCCTTGTGGGTGCTGATGTGGACTCC
CAAGAGCTGTGGATTGCAGCTGTGCTTGGAGACGCCCACTTTGCCGGCATGCATGGCACCCCGACTATGATGAGGAAGGCCTCTATGGGG
CCATCCTGCCCCAAGTGGTGACTGCCGGCACCATCACTCGCCGGGCTGTGGAGCCCACATGGCTCACCGCCAGCAATGCCCGGCTCCCAG
ATGGTGGTGTGGCTGCCCAGGTCAGCTCTGCCCCGTGCTGTGATCAGGATGGTAATAGCTGTAATGTGGGAAGCCCCTTTGCCAAGGACT
TCCTGCCCAAGATGGAGGATGGCACCCTGCAGGCTGGCCCAGGAGGTGCCAGTGGGCCCCGTGCTCTGGAAATCAACAAAATGATTTCTT
TCTGGAGGAACGCCCATAAACGTATCAGACTGCCCGTGGTGGCCCCAAGGACACCCAGCCCAGCTATCACCATGGCAATGGACCTTACAA
CGACGTGGACATCCCTGGCTGCTGGTTTTTCAAGCTGCCTCACAAGGTAGAAGAACTGGATTACTTAGAAGTGGAGGCTGAGGCCAAGAT
GGAGAACTTGCGAGCTGCAGTGCCAGGTCAACCCCTAGCTCTGAGCCATCGAGTCCCTGTACAGGAAGCACTGTCTCGAACAGGGGAAGC
AGCAGCTGATGCCCCAGGAGGCCGGCCTGGCGGAGGAGTTCCTGCTCACTGACAATAGTGCCATATGGCAAACGATGGTACCGGAAGCTC
TGCCCCCGGCTAGACGACCCTGCATGGACCCCGGGCCCCAGCCTCCTCAGCCTGCAGATGCGGGTCACACCTAAACTCATGGCACTTACC
TGGGATGGCTTCCCTCTGCACTACTCAGAGCGTCATGGCTGGGGCTACTTGGTGCCTGGGCGGCGGGACAACCTGGCCAAGCTGCCGACA
GGTACCACCCTGGAGTCAGCTGGGGTGGTCTGCCCCTACAGACCTCGGCCCCTGCAGTGAGGAGGAGGAGTTTCAACAAGATGTCATGGC
CCGCGCCTGCTTGCAGAAGCTGAAGGGGACCACAGAGCTCCTGCCCAAGCGGCCCCAGCACCTTCCTGGACACCCTGGGTACAAAGAAGA
CCCCTGGCTCTGGGACCTGGAGTGGGACCTGCAAGAATTTAAGCAGAAGAAAGCTAAGAAGGTGAAGAAGGAACCAGCCACAGCCAGCAA
GTTGCCCATCGAGGGGGCTGGGGCCCCTGGTGATCCCATGGATCAGGAAGGTGTCCCCACCCAGTGACTCTGGCCGGCATGCTGGAGATG
GGTGTCTCCTACCTGCCTGTCAACCAGAACTGGGAGCGTTACCTGGCAGAGGCACAGGGCACTTATGAGGAGCTCCAGCGGGAGATGAAG
AAGTCGTTGATGGATCTGGCCAATGATGCCTGCCAGCTGCTCTCAGGAGAGAGGACCTGATGCAGTACTGTGCCCAGGACGTGTGGGCCA
CCCATGAGGTTTTCCAGCAGCAGCTACCGCTCTTCTTGGAGAGATCTCATCCTGGGACTGGCTGGACATCAGCAGTGTCAACAGTCTGGC
AGAGGTGCACAGACTTTATGTAGGGGGGCCTCCCTTAGAGAAGGAGCCTCGAGAACTGTTTGTGAAGGGCACCATGAAGGACATTCGTGA
GAACTTCCAGGGTTCCCGCATGCGTTTCCTGGACACCATGAGCATGCACATGGCCATCTCAGGGCTAAGCAGCTTCCAGCGCAGTCTGTG
GATAGCAGCCAAGCAGGGCAAACACAAGGTCCAGCCCCCCACAAAGCAAGGCCAGAAGTCCCAGAGGAAAGCCAGAAGAGGCCCAGCGGT
ATTCCTGGTGCAGCCAGCGGCTGGTGGAAGAGCGTTACTCTTGGACCAGCCAGCTGTCGCCGGCTGACCTCATCCCCCTGGAGGTCCCTA
CTGGTGCCAGCAGCCCCACCCAGAGAGACTGGCAGGAGCAGTTAGTGGTGGGGCACAATGTTTCCTTTGACCGAGCTCATATCAGGGAGC
AGTACCTGATCCAGCTGGACCAGCACTTCCGCCTCCTGGCCCAGAAGCAGAGCCTGCCCTACCTGGAGGCGGCCAACTTGCTGTTGCAGG
CCCAGCTGCCCCCGAAGCCCCCGGCTTGGGCCTGGGCGGAGGGCTGGACCCGGTACGGCCCCGAGGGGGAGGCCGTACCCGTGGCCATCC
CCGAGGAGCGGGCCCTGGTGTTCGACGTGGAGGTCTGCTTGGCAGAGGGAACTTGCCCCACATTGGCGGTGGCCATATCCCCCTCGGCCT

>34298_34298_4_GPI-POLG_GPI_chr19_34884673_ENST00000415930_POLG_chr15_89876583_ENST00000442287_length(amino acids)=322AA_BP=
MVALCSLQHLGSSDPRALPTLPTATSGQRPAKRRRKSPAMAALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHI
LVDYSKNLVTEDVMRMLVDLAKSRGVEAARERMFNGEKINYTEGRAVLHVALRNRSNTPILVDGKDVMPEVNKVLDKMKSFCQGPLMVTE
ALKPYSSGGPRVWYVSNIDGTHIAKTLAQLNPESSLFIIASKTFTTQETITNAETAKEWFLQAAKDPSAVAKHFVALSTNTTKVKEFGID

--------------------------------------------------------------
>34298_34298_5_GPI-POLG_GPI_chr19_34884673_ENST00000586425_POLG_chr15_89876583_ENST00000268124_length(transcript)=4700nt_BP=934nt
ACTCAGTGTACCTTCTAGTCCCGCCATGGCCGCTCTCACCCGGGACCCCCAGTTCCAGAAGCTGCAGCAATGGTACCGCGAGCACCGCTC
CGAGCTGAACCTGCGCCGCCTCTTCGATGCCAACAAGGACCGCTTCAACCACTTCAGCTTGACCCTCAACACCAACCATGGGCATATCCT
GGTGGATTACTCCAAGAACCTGGTGACGGAGGACGTGATGCGGATGCTGGTGGACTTGGCCAAGTCCAGGGGCGTGGAGGCCGCCCGGGA
GCGGATGTTCAATGGTGAGAAGATCAACTACACCGAGGGTCGAGCCGTGCTGCACGTGGCTCTGCGGAACCGGTCAAACACACCCATCCT
GGTAGACGGCAAGGATGTGATGCCAGAGGTCAACAAGGTTCTGGACAAGATGAAGTCTTTCTGCCAGCGTGTCCGGAGCGGTGACTGGAA
GGGGTACACAGGCAAGACCATCACGGACGTCATCAACATTGGCATTGGCGGCTCCGACCTGGGACCCCTCATGGTGACTGAAGCCCTTAA
GCCATACTCTTCAGGAGGTCCCCGCGTCTGGTATGTCTCCAACATTGATGGAACTCACATTGCCAAAACCCTGGCCCAGCTGAACCCCGA
GTCCTCCCTGTTCATCATTGCCTCCAAGACCTTTACTACCCAGGAGACCATCACGAATGCAGAGACGGCGAAGGAGTGGTTTCTCCAGGC
GGCCAAGGATCCTTCTGCAGTGGCGAAGCACTTTGTTGCCCTGTCTACTAACACAACCAAAGTGAAGGAGTTTGGAATTGACCCTCAAAA
CATGTTCGAGTTCTGGGATTGGGTGGGAGGACGCTACTCGCTGTGGTCGGCCATCGGACTCTCCATTGCCCTGCACGTGGGTTTTGACAA
CTTCGAGCAGCTGCTCTCGGGGGCTCACTGGATGGTGAAGCGCTGGATATTTACCAGATAATTGAACTCACCAAAGGCTCCTTGGAAAAA
CGAAGCCAGCCTGGACCATAGCACTGCCTGGAGGCTCTGTATTTGCTCCCGTGGAGCTTCATCGGGGTGGTGCAGGCTCCCAAACTCAGG
CTTTCAGCTGTGCTTTTTGCAAAAGGGCTTGCCTAAGGCCAGCCATTTTTCAGTAGCAGGACCTGCCAAGAAGATTCCTTCTAACTGAAG
GTGCAGTTGAATTCAGTGGGTTCAGAACCAAGATGCCAACATCGGTGTGGACTACAGGACAAGGGGCATTGTTGCTTGTTGGGTAAAAAT
GAAGCAGAAGCCCCAAAGTTCACATTAACTCAGGCATTTCATTTATTTTTTCCTTTTCTTCTTGGCTGGTTCTTTGTTCTGTCCCCCATG
CTCTGATGCAGTGCCCTAGAAGGGGAAAGAATTAATGCTCTAACGTGATAAACCTGCTCCAAGGCAGTGGAAATAAAAAGAAGGAAAAAA
AAGACTCTATCTTCTCATCGTGCATGTTTGCCTACAAGCTGGGTCTGAATGACTTGCCCCAGTCAGTCGCCTTTTTCAGTGCAGTCGATA
TTGACCGGTGCCTCAGGAAGGAAGTGACCATGGATTGTAAAACCCCTTCCAACCCAACTGGGATGGAAAGGAGATACGGGATTCCCCAGG
TTTATGACCAGCCGTGTGAATTGGGTGGTACAGAGCTCTGCTGTTGACTACTTACACCTCATGCTTGTGGCCATGAAGTGGCTGTTTGAA
GAGTTTGCCATAGATGGGCGCTTCTGCATCAGCATCCATGACGAGGTTCGCTACCTGGTGCGGGAGGAGGACCGCTACCGCGCTGCCCTG
GCCTTGCAGATCACCAACCTCTTGACCAGGTCACAGTGGAAGAAGTGGGAGGTGGTTGCTGAACGGGCATGGAAGGGGGGCACAGAGTCA
GAAATGTTCAATAAGCTTGAGAGCATTGCTACGTCTGACATACCACGTACCCCGGTGCTGGGCTGCTGCATCAGCCGAGCCCTGGAGCCC
TCGGCTGTCCAGGAAGAGGTATCGGCTGTCGGATGAGGGCGAGTGGCTGGTGAGGGAGTTGAACCTCCCAGTGGACAGGACTGAGGGTGG
CTGGATTTCCCTGCAGGATCTGCGCAAGGTCCAGAGAGAAACTGCAAGGAAGCTGCACAGCCTTTGGGTGGATGACACTGCAGGGCAGGA
AGAGCAGGGGCACTGATCTACACAGTAAGACAGCCACTACTGTGGGCATCAGCCGTGAGCATGCCAAAATCTTCAACTACGGCCGCATCT
ATGGTGCTGGGCAGCCCTTTGCTGAGCGCTTACTAATGCAGTTTAACCACCGGCTCACACAGCAGGAGGCAGCTGAGAAGGCCCAGCAGA
TGTACGCTGCCACCAAGGGCCTCCGCTGCCTGACCGAGTAGGCAGTGAGTTGAAAGCCATGGTGCAGGCCCCACCTGGCTACACCCTTGT
GGGTGCTGATGTGGACTCCCAAGAGCTGTGGATTGCAGCTGTGCTTGGAGACGCCCACTTTGCCGGCATGCATGGCACCCCGACTATGAT
GAGGAAGGCCTCTATGGGGCCATCCTGCCCCAAGTGGTGACTGCCGGCACCATCACTCGCCGGGCTGTGGAGCCCACATGGCTCACCGCC
AGCAATGCCCGGCTCCCAGATGGTGGTGTGGCTGCCCAGGTCAGCTCTGCCCCGTGCTGTGATCAGGATGGTAATAGCTGTAATGTGGGA
AGCCCCTTTGCCAAGGACTTCCTGCCCAAGATGGAGGATGGCACCCTGCAGGCTGGCCCAGGAGGTGCCAGTGGGCCCCGTGCTCTGGAA
ATCAACAAAATGATTTCTTTCTGGAGGAACGCCCATAAACGTATCAGACTGCCCGTGGTGGCCCCAAGGACACCCAGCCCAGCTATCACC
ATGGCAATGGACCTTACAACGACGTGGACATCCCTGGCTGCTGGTTTTTCAAGCTGCCTCACAAGGTAGAAGAACTGGATTACTTAGAAG
TGGAGGCTGAGGCCAAGATGGAGAACTTGCGAGCTGCAGTGCCAGGTCAACCCCTAGCTCTGAGCCATCGAGTCCCTGTACAGGAAGCAC
TGTCTCGAACAGGGGAAGCAGCAGCTGATGCCCCAGGAGGCCGGCCTGGCGGAGGAGTTCCTGCTCACTGACAATAGTGCCATATGGCAA
ACGATGGTACCGGAAGCTCTGCCCCCGGCTAGACGACCCTGCATGGACCCCGGGCCCCAGCCTCCTCAGCCTGCAGATGCGGGTCACACC
TAAACTCATGGCACTTACCTGGGATGGCTTCCCTCTGCACTACTCAGAGCGTCATGGCTGGGGCTACTTGGTGCCTGGGCGGCGGGACAA
CCTGGCCAAGCTGCCGACAGGTACCACCCTGGAGTCAGCTGGGGTGGTCTGCCCCTACAGACCTCGGCCCCTGCAGTGAGGAGGAGGAGT
TTCAACAAGATGTCATGGCCCGCGCCTGCTTGCAGAAGCTGAAGGGGACCACAGAGCTCCTGCCCAAGCGGCCCCAGCACCTTCCTGGAC
ACCCTGGGTACAAAGAAGACCCCTGGCTCTGGGACCTGGAGTGGGACCTGCAAGAATTTAAGCAGAAGAAAGCTAAGAAGGTGAAGAAGG
AACCAGCCACAGCCAGCAAGTTGCCCATCGAGGGGGCTGGGGCCCCTGGTGATCCCATGGATCAGGAAGGTGTCCCCACCCAGTGACTCT
GGCCGGCATGCTGGAGATGGGTGTCTCCTACCTGCCTGTCAACCAGAACTGGGAGCGTTACCTGGCAGAGGCACAGGGCACTTATGAGGA
GCTCCAGCGGGAGATGAAGAAGTCGTTGATGGATCTGGCCAATGATGCCTGCCAGCTGCTCTCAGGAGAGAGGACCTGATGCAGTACTGT
GCCCAGGACGTGTGGGCCACCCATGAGGTTTTCCAGCAGCAGCTACCGCTCTTCTTGGAGAGATCTCATCCTGGGACTGGCTGGACATCA
GCAGTGTCAACAGTCTGGCAGAGGTGCACAGACTTTATGTAGGGGGGCCTCCCTTAGAGAAGGAGCCTCGAGAACTGTTTGTGAAGGGCA
CCATGAAGGACATTCGTGAGAACTTCCAGGGTTCCCGCATGCGTTTCCTGGACACCATGAGCATGCACATGGCCATCTCAGGGCTAAGCA
GCTTCCAGCGCAGTCTGTGGATAGCAGCCAAGCAGGGCAAACACAAGGTCCAGCCCCCCACAAAGCAAGGCCAGAAGTCCCAGAGGAAAG
CCAGAAGAGGCCCAGCGGTATTCCTGGTGCAGCCAGCGGCTGGTGGAAGAGCGTTACTCTTGGACCAGCCAGCTGTCGCCGGCTGACCTC
ATCCCCCTGGAGGTCCCTACTGGTGCCAGCAGCCCCACCCAGAGAGACTGGCAGGAGCAGTTAGTGGTGGGGCACAATGTTTCCTTTGAC
CGAGCTCATATCAGGGAGCAGTACCTGATCCAGCTGGACCAGCACTTCCGCCTCCTGGCCCAGAAGCAGAGCCTGCCCTACCTGGAGGCG
GCCAACTTGCTGTTGCAGGCCCAGCTGCCCCCGAAGCCCCCGGCTTGGGCCTGGGCGGAGGGCTGGACCCGGTACGGCCCCGAGGGGGAG
GCCGTACCCGTGGCCATCCCCGAGGAGCGGGCCCTGGTGTTCGACGTGGAGGTCTGCTTGGCAGAGGGAACTTGCCCCACATTGGCGGTG

>34298_34298_5_GPI-POLG_GPI_chr19_34884673_ENST00000586425_POLG_chr15_89876583_ENST00000268124_length(amino acids)=311AA_BP=
MAALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHILVDYSKNLVTEDVMRMLVDLAKSRGVEAARERMFNGEKI
NYTEGRAVLHVALRNRSNTPILVDGKDVMPEVNKVLDKMKSFCQRVRSGDWKGYTGKTITDVINIGIGGSDLGPLMVTEALKPYSSGGPR
VWYVSNIDGTHIAKTLAQLNPESSLFIIASKTFTTQETITNAETAKEWFLQAAKDPSAVAKHFVALSTNTTKVKEFGIDPQNMFEFWDWV

--------------------------------------------------------------
>34298_34298_6_GPI-POLG_GPI_chr19_34884673_ENST00000586425_POLG_chr15_89876583_ENST00000442287_length(transcript)=4683nt_BP=934nt
ACTCAGTGTACCTTCTAGTCCCGCCATGGCCGCTCTCACCCGGGACCCCCAGTTCCAGAAGCTGCAGCAATGGTACCGCGAGCACCGCTC
CGAGCTGAACCTGCGCCGCCTCTTCGATGCCAACAAGGACCGCTTCAACCACTTCAGCTTGACCCTCAACACCAACCATGGGCATATCCT
GGTGGATTACTCCAAGAACCTGGTGACGGAGGACGTGATGCGGATGCTGGTGGACTTGGCCAAGTCCAGGGGCGTGGAGGCCGCCCGGGA
GCGGATGTTCAATGGTGAGAAGATCAACTACACCGAGGGTCGAGCCGTGCTGCACGTGGCTCTGCGGAACCGGTCAAACACACCCATCCT
GGTAGACGGCAAGGATGTGATGCCAGAGGTCAACAAGGTTCTGGACAAGATGAAGTCTTTCTGCCAGCGTGTCCGGAGCGGTGACTGGAA
GGGGTACACAGGCAAGACCATCACGGACGTCATCAACATTGGCATTGGCGGCTCCGACCTGGGACCCCTCATGGTGACTGAAGCCCTTAA
GCCATACTCTTCAGGAGGTCCCCGCGTCTGGTATGTCTCCAACATTGATGGAACTCACATTGCCAAAACCCTGGCCCAGCTGAACCCCGA
GTCCTCCCTGTTCATCATTGCCTCCAAGACCTTTACTACCCAGGAGACCATCACGAATGCAGAGACGGCGAAGGAGTGGTTTCTCCAGGC
GGCCAAGGATCCTTCTGCAGTGGCGAAGCACTTTGTTGCCCTGTCTACTAACACAACCAAAGTGAAGGAGTTTGGAATTGACCCTCAAAA
CATGTTCGAGTTCTGGGATTGGGTGGGAGGACGCTACTCGCTGTGGTCGGCCATCGGACTCTCCATTGCCCTGCACGTGGGTTTTGACAA
CTTCGAGCAGCTGCTCTCGGGGGCTCACTGGATGGTGAAGCGCTGGATATTTACCAGATAATTGAACTCACCAAAGGCTCCTTGGAAAAA
CGAAGCCAGCCTGGACCATAGCACTGCCTGGAGGCTCTGTATTTGCTCCCGTGGAGCTTCATCGGGGTGGTGCAGGCTCCCAAACTCAGG
CTTTCAGCTGTGCTTTTTGCAAAAGGGCTTGCCTAAGGCCAGCCATTTTTCAGTAGCAGGACCTGCCAAGAAGATTCCTTCTAACTGAAG
GTGCAGTTGAATTCAGTGGGTTCAGAACCAAGATGCCAACATCGGTGTGGACTACAGGACAAGGGGCATTGTTGCTTGTTGGGTAAAAAT
GAAGCAGAAGCCCCAAAGTTCACATTAACTCAGGCATTTCATTTATTTTTTCCTTTTCTTCTTGGCTGGTTCTTTGTTCTGTCCCCCATG
CTCTGATGCAGTGCCCTAGAAGGGGAAAGAATTAATGCTCTAACGTGATAAACCTGCTCCAAGGCAGTGGAAATAAAAAGAAGGAAAAAA
AAGTGCATGTTTGCCTACAAGCTGGGTCTGAATGACTTGCCCCAGTCAGTCGCCTTTTTCAGTGCAGTCGATATTGACCGGTGCCTCAGG
AAGGAAGTGACCATGGATTGTAAAACCCCTTCCAACCCAACTGGGATGGAAAGGAGATACGGGATTCCCCAGGTTTATGACCAGCCGTGT
GAATTGGGTGGTACAGAGCTCTGCTGTTGACTACTTACACCTCATGCTTGTGGCCATGAAGTGGCTGTTTGAAGAGTTTGCCATAGATGG
GCGCTTCTGCATCAGCATCCATGACGAGGTTCGCTACCTGGTGCGGGAGGAGGACCGCTACCGCGCTGCCCTGGCCTTGCAGATCACCAA
CCTCTTGACCAGGTCACAGTGGAAGAAGTGGGAGGTGGTTGCTGAACGGGCATGGAAGGGGGGCACAGAGTCAGAAATGTTCAATAAGCT
TGAGAGCATTGCTACGTCTGACATACCACGTACCCCGGTGCTGGGCTGCTGCATCAGCCGAGCCCTGGAGCCCTCGGCTGTCCAGGAAGA
GGTATCGGCTGTCGGATGAGGGCGAGTGGCTGGTGAGGGAGTTGAACCTCCCAGTGGACAGGACTGAGGGTGGCTGGATTTCCCTGCAGG
ATCTGCGCAAGGTCCAGAGAGAAACTGCAAGGAAGCTGCACAGCCTTTGGGTGGATGACACTGCAGGGCAGGAAGAGCAGGGGCACTGAT
CTACACAGTAAGACAGCCACTACTGTGGGCATCAGCCGTGAGCATGCCAAAATCTTCAACTACGGCCGCATCTATGGTGCTGGGCAGCCC
TTTGCTGAGCGCTTACTAATGCAGTTTAACCACCGGCTCACACAGCAGGAGGCAGCTGAGAAGGCCCAGCAGATGTACGCTGCCACCAAG
GGCCTCCGCTGCCTGACCGAGTAGGCAGTGAGTTGAAAGCCATGGTGCAGGCCCCACCTGGCTACACCCTTGTGGGTGCTGATGTGGACT
CCCAAGAGCTGTGGATTGCAGCTGTGCTTGGAGACGCCCACTTTGCCGGCATGCATGGCACCCCGACTATGATGAGGAAGGCCTCTATGG
GGCCATCCTGCCCCAAGTGGTGACTGCCGGCACCATCACTCGCCGGGCTGTGGAGCCCACATGGCTCACCGCCAGCAATGCCCGGCTCCC
AGATGGTGGTGTGGCTGCCCAGGTCAGCTCTGCCCCGTGCTGTGATCAGGATGGTAATAGCTGTAATGTGGGAAGCCCCTTTGCCAAGGA
CTTCCTGCCCAAGATGGAGGATGGCACCCTGCAGGCTGGCCCAGGAGGTGCCAGTGGGCCCCGTGCTCTGGAAATCAACAAAATGATTTC
TTTCTGGAGGAACGCCCATAAACGTATCAGACTGCCCGTGGTGGCCCCAAGGACACCCAGCCCAGCTATCACCATGGCAATGGACCTTAC
AACGACGTGGACATCCCTGGCTGCTGGTTTTTCAAGCTGCCTCACAAGGTAGAAGAACTGGATTACTTAGAAGTGGAGGCTGAGGCCAAG
ATGGAGAACTTGCGAGCTGCAGTGCCAGGTCAACCCCTAGCTCTGAGCCATCGAGTCCCTGTACAGGAAGCACTGTCTCGAACAGGGGAA
GCAGCAGCTGATGCCCCAGGAGGCCGGCCTGGCGGAGGAGTTCCTGCTCACTGACAATAGTGCCATATGGCAAACGATGGTACCGGAAGC
TCTGCCCCCGGCTAGACGACCCTGCATGGACCCCGGGCCCCAGCCTCCTCAGCCTGCAGATGCGGGTCACACCTAAACTCATGGCACTTA
CCTGGGATGGCTTCCCTCTGCACTACTCAGAGCGTCATGGCTGGGGCTACTTGGTGCCTGGGCGGCGGGACAACCTGGCCAAGCTGCCGA
CAGGTACCACCCTGGAGTCAGCTGGGGTGGTCTGCCCCTACAGACCTCGGCCCCTGCAGTGAGGAGGAGGAGTTTCAACAAGATGTCATG
GCCCGCGCCTGCTTGCAGAAGCTGAAGGGGACCACAGAGCTCCTGCCCAAGCGGCCCCAGCACCTTCCTGGACACCCTGGGTACAAAGAA
GACCCCTGGCTCTGGGACCTGGAGTGGGACCTGCAAGAATTTAAGCAGAAGAAAGCTAAGAAGGTGAAGAAGGAACCAGCCACAGCCAGC
AAGTTGCCCATCGAGGGGGCTGGGGCCCCTGGTGATCCCATGGATCAGGAAGGTGTCCCCACCCAGTGACTCTGGCCGGCATGCTGGAGA
TGGGTGTCTCCTACCTGCCTGTCAACCAGAACTGGGAGCGTTACCTGGCAGAGGCACAGGGCACTTATGAGGAGCTCCAGCGGGAGATGA
AGAAGTCGTTGATGGATCTGGCCAATGATGCCTGCCAGCTGCTCTCAGGAGAGAGGACCTGATGCAGTACTGTGCCCAGGACGTGTGGGC
CACCCATGAGGTTTTCCAGCAGCAGCTACCGCTCTTCTTGGAGAGATCTCATCCTGGGACTGGCTGGACATCAGCAGTGTCAACAGTCTG
GCAGAGGTGCACAGACTTTATGTAGGGGGGCCTCCCTTAGAGAAGGAGCCTCGAGAACTGTTTGTGAAGGGCACCATGAAGGACATTCGT
GAGAACTTCCAGGGTTCCCGCATGCGTTTCCTGGACACCATGAGCATGCACATGGCCATCTCAGGGCTAAGCAGCTTCCAGCGCAGTCTG
TGGATAGCAGCCAAGCAGGGCAAACACAAGGTCCAGCCCCCCACAAAGCAAGGCCAGAAGTCCCAGAGGAAAGCCAGAAGAGGCCCAGCG
GTATTCCTGGTGCAGCCAGCGGCTGGTGGAAGAGCGTTACTCTTGGACCAGCCAGCTGTCGCCGGCTGACCTCATCCCCCTGGAGGTCCC
TACTGGTGCCAGCAGCCCCACCCAGAGAGACTGGCAGGAGCAGTTAGTGGTGGGGCACAATGTTTCCTTTGACCGAGCTCATATCAGGGA
GCAGTACCTGATCCAGCTGGACCAGCACTTCCGCCTCCTGGCCCAGAAGCAGAGCCTGCCCTACCTGGAGGCGGCCAACTTGCTGTTGCA
GGCCCAGCTGCCCCCGAAGCCCCCGGCTTGGGCCTGGGCGGAGGGCTGGACCCGGTACGGCCCCGAGGGGGAGGCCGTACCCGTGGCCAT
CCCCGAGGAGCGGGCCCTGGTGTTCGACGTGGAGGTCTGCTTGGCAGAGGGAACTTGCCCCACATTGGCGGTGGCCATATCCCCCTCGGC

>34298_34298_6_GPI-POLG_GPI_chr19_34884673_ENST00000586425_POLG_chr15_89876583_ENST00000442287_length(amino acids)=311AA_BP=
MAALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHILVDYSKNLVTEDVMRMLVDLAKSRGVEAARERMFNGEKI
NYTEGRAVLHVALRNRSNTPILVDGKDVMPEVNKVLDKMKSFCQRVRSGDWKGYTGKTITDVINIGIGGSDLGPLMVTEALKPYSSGGPR
VWYVSNIDGTHIAKTLAQLNPESSLFIIASKTFTTQETITNAETAKEWFLQAAKDPSAVAKHFVALSTNTTKVKEFGIDPQNMFEFWDWV

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for GPI-POLG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for GPI-POLG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for GPI-POLG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource