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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GPR107-FNBP1 (FusionGDB2 ID:34347)

Fusion Gene Summary for GPR107-FNBP1

check button Fusion gene summary
Fusion gene informationFusion gene name: GPR107-FNBP1
Fusion gene ID: 34347
HgeneTgene
Gene symbol

GPR107

FNBP1

Gene ID

57720

23048

Gene nameG protein-coupled receptor 107formin binding protein 1
SynonymsGCDRP|LUSTR1|bA138E2.2FBP17
Cytomap

9q34.11

9q34.11

Type of geneprotein-codingprotein-coding
Descriptionprotein GPR107lung seven transmembrane receptor 1formin-binding protein 1formin-binding protein 17
Modification date2020031320200313
UniProtAcc

Q5VW38

Q5T0N5

Ensembl transtripts involved in fusion geneENST00000347136, ENST00000372406, 
ENST00000372410, ENST00000415344, 
ENST00000443566, ENST00000478129, 
ENST00000355681, ENST00000420781, 
ENST00000446176, 
Fusion gene scores* DoF score9 X 9 X 5=40524 X 24 X 8=4608
# samples 926
** MAII scorelog2(9/405*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(26/4608*10)=-4.14755718841386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GPR107 [Title/Abstract] AND FNBP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGPR107(132816352)-FNBP1(132757237), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across GPR107 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FNBP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A1X8-01AGPR107chr9

132816352

+FNBP1chr9

132757237

-
ChimerDB4STADTCGA-BR-8059-01AGPR107chr9

132816352

+FNBP1chr9

132757237

-


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Fusion Gene ORF analysis for GPR107-FNBP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000347136ENST00000443566GPR107chr9

132816352

+FNBP1chr9

132757237

-
5CDS-intronENST00000347136ENST00000478129GPR107chr9

132816352

+FNBP1chr9

132757237

-
5CDS-intronENST00000372406ENST00000443566GPR107chr9

132816352

+FNBP1chr9

132757237

-
5CDS-intronENST00000372406ENST00000478129GPR107chr9

132816352

+FNBP1chr9

132757237

-
5CDS-intronENST00000372410ENST00000443566GPR107chr9

132816352

+FNBP1chr9

132757237

-
5CDS-intronENST00000372410ENST00000478129GPR107chr9

132816352

+FNBP1chr9

132757237

-
In-frameENST00000347136ENST00000355681GPR107chr9

132816352

+FNBP1chr9

132757237

-
In-frameENST00000347136ENST00000420781GPR107chr9

132816352

+FNBP1chr9

132757237

-
In-frameENST00000347136ENST00000446176GPR107chr9

132816352

+FNBP1chr9

132757237

-
In-frameENST00000372406ENST00000355681GPR107chr9

132816352

+FNBP1chr9

132757237

-
In-frameENST00000372406ENST00000420781GPR107chr9

132816352

+FNBP1chr9

132757237

-
In-frameENST00000372406ENST00000446176GPR107chr9

132816352

+FNBP1chr9

132757237

-
In-frameENST00000372410ENST00000355681GPR107chr9

132816352

+FNBP1chr9

132757237

-
In-frameENST00000372410ENST00000420781GPR107chr9

132816352

+FNBP1chr9

132757237

-
In-frameENST00000372410ENST00000446176GPR107chr9

132816352

+FNBP1chr9

132757237

-
intron-3CDSENST00000415344ENST00000355681GPR107chr9

132816352

+FNBP1chr9

132757237

-
intron-3CDSENST00000415344ENST00000420781GPR107chr9

132816352

+FNBP1chr9

132757237

-
intron-3CDSENST00000415344ENST00000446176GPR107chr9

132816352

+FNBP1chr9

132757237

-
intron-intronENST00000415344ENST00000443566GPR107chr9

132816352

+FNBP1chr9

132757237

-
intron-intronENST00000415344ENST00000478129GPR107chr9

132816352

+FNBP1chr9

132757237

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for GPR107-FNBP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GPR107-FNBP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:132816352/chr9:132757237)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPR107

Q5VW38

FNBP1

Q5T0N5

FUNCTION: Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (PubMed:22933024). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). {ECO:0000250|UniProtKB:D3ZWZ9, ECO:0000269|PubMed:22933024}.; FUNCTION: (Microbial infection) Required for intoxication by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT. May contribute to the retrograde transport of bacterial toxins, including cholera toxin, from the trans-Golgi network to the endoplasmic reticulum. {ECO:0000269|PubMed:25031321}.FUNCTION: Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens. {ECO:0000269|PubMed:15260990, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:19342671}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFNBP1chr9:132816352chr9:132757237ENST00000355681016398_4908593.0Coiled coilOntology_term=ECO:0000250
TgeneFNBP1chr9:132816352chr9:132757237ENST0000035568101667_2598593.0Coiled coilOntology_term=ECO:0000269
TgeneFNBP1chr9:132816352chr9:132757237ENST00000446176017398_4908618.0Coiled coilOntology_term=ECO:0000250
TgeneFNBP1chr9:132816352chr9:132757237ENST0000044617601767_2598618.0Coiled coilOntology_term=ECO:0000269
TgeneFNBP1chr9:132816352chr9:132757237ENST00000355681016340_3458593.0Compositional biasNote=Poly-Pro
TgeneFNBP1chr9:132816352chr9:132757237ENST00000446176017340_3458618.0Compositional biasNote=Poly-Pro
TgeneFNBP1chr9:132816352chr9:132757237ENST00000355681016404_4818593.0DomainREM-1
TgeneFNBP1chr9:132816352chr9:132757237ENST00000355681016550_6118593.0DomainSH3
TgeneFNBP1chr9:132816352chr9:132757237ENST00000446176017404_4818618.0DomainREM-1
TgeneFNBP1chr9:132816352chr9:132757237ENST00000446176017550_6118618.0DomainSH3
TgeneFNBP1chr9:132816352chr9:132757237ENST00000355681016251_6178593.0RegionNote=Required for self-association and induction of membrane tubulation
TgeneFNBP1chr9:132816352chr9:132757237ENST00000446176017251_6178618.0RegionNote=Required for self-association and induction of membrane tubulation

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGPR107chr9:132816352chr9:132757237ENST00000347136+118285_29347553.0Topological domainCytoplasmic
HgeneGPR107chr9:132816352chr9:132757237ENST00000347136+118315_33747553.0Topological domainExtracellular
HgeneGPR107chr9:132816352chr9:132757237ENST00000347136+118359_36847553.0Topological domainCytoplasmic
HgeneGPR107chr9:132816352chr9:132757237ENST00000347136+118390_40247553.0Topological domainExtracellular
HgeneGPR107chr9:132816352chr9:132757237ENST00000347136+11840_26347553.0Topological domainExtracellular
HgeneGPR107chr9:132816352chr9:132757237ENST00000347136+118424_49847553.0Topological domainCytoplasmic
HgeneGPR107chr9:132816352chr9:132757237ENST00000347136+118520_52447553.0Topological domainExtracellular
HgeneGPR107chr9:132816352chr9:132757237ENST00000347136+118545_60047553.0Topological domainCytoplasmic
HgeneGPR107chr9:132816352chr9:132757237ENST00000372406+120285_29347601.0Topological domainCytoplasmic
HgeneGPR107chr9:132816352chr9:132757237ENST00000372406+120315_33747601.0Topological domainExtracellular
HgeneGPR107chr9:132816352chr9:132757237ENST00000372406+120359_36847601.0Topological domainCytoplasmic
HgeneGPR107chr9:132816352chr9:132757237ENST00000372406+120390_40247601.0Topological domainExtracellular
HgeneGPR107chr9:132816352chr9:132757237ENST00000372406+12040_26347601.0Topological domainExtracellular
HgeneGPR107chr9:132816352chr9:132757237ENST00000372406+120424_49847601.0Topological domainCytoplasmic
HgeneGPR107chr9:132816352chr9:132757237ENST00000372406+120520_52447601.0Topological domainExtracellular
HgeneGPR107chr9:132816352chr9:132757237ENST00000372406+120545_60047601.0Topological domainCytoplasmic
HgeneGPR107chr9:132816352chr9:132757237ENST00000347136+118264_28447553.0TransmembraneHelical%3B Name%3D1
HgeneGPR107chr9:132816352chr9:132757237ENST00000347136+118294_31447553.0TransmembraneHelical%3B Name%3D2
HgeneGPR107chr9:132816352chr9:132757237ENST00000347136+118338_35847553.0TransmembraneHelical%3B Name%3D3
HgeneGPR107chr9:132816352chr9:132757237ENST00000347136+118369_38947553.0TransmembraneHelical%3B Name%3D4
HgeneGPR107chr9:132816352chr9:132757237ENST00000347136+118403_42347553.0TransmembraneHelical%3B Name%3D5
HgeneGPR107chr9:132816352chr9:132757237ENST00000347136+118499_51947553.0TransmembraneHelical%3B Name%3D6
HgeneGPR107chr9:132816352chr9:132757237ENST00000347136+118525_54447553.0TransmembraneHelical%3B Name%3D7
HgeneGPR107chr9:132816352chr9:132757237ENST00000372406+120264_28447601.0TransmembraneHelical%3B Name%3D1
HgeneGPR107chr9:132816352chr9:132757237ENST00000372406+120294_31447601.0TransmembraneHelical%3B Name%3D2
HgeneGPR107chr9:132816352chr9:132757237ENST00000372406+120338_35847601.0TransmembraneHelical%3B Name%3D3
HgeneGPR107chr9:132816352chr9:132757237ENST00000372406+120369_38947601.0TransmembraneHelical%3B Name%3D4
HgeneGPR107chr9:132816352chr9:132757237ENST00000372406+120403_42347601.0TransmembraneHelical%3B Name%3D5
HgeneGPR107chr9:132816352chr9:132757237ENST00000372406+120499_51947601.0TransmembraneHelical%3B Name%3D6
HgeneGPR107chr9:132816352chr9:132757237ENST00000372406+120525_54447601.0TransmembraneHelical%3B Name%3D7
TgeneFNBP1chr9:132816352chr9:132757237ENST000003556810161_2648593.0DomainF-BAR
TgeneFNBP1chr9:132816352chr9:132757237ENST000004461760171_2648618.0DomainF-BAR
TgeneFNBP1chr9:132816352chr9:132757237ENST000003556810161_798593.0RegionNote=Required for self-association and induction of membrane tubulation
TgeneFNBP1chr9:132816352chr9:132757237ENST000004461760171_798618.0RegionNote=Required for self-association and induction of membrane tubulation


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Fusion Gene Sequence for GPR107-FNBP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GPR107-FNBP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneFNBP1chr9:132816352chr9:132757237ENST00000355681016550_6178.0593.0ARHGAP17%2C DAAM1%2C DIAPH1 and DIAPH2
TgeneFNBP1chr9:132816352chr9:132757237ENST00000446176017550_6178.0618.0ARHGAP17%2C DAAM1%2C DIAPH1 and DIAPH2
TgeneFNBP1chr9:132816352chr9:132757237ENST00000355681016535_6178.0593.0DNM1 and DNM3
TgeneFNBP1chr9:132816352chr9:132757237ENST00000446176017535_6178.0618.0DNM1 and DNM3
TgeneFNBP1chr9:132816352chr9:132757237ENST00000355681016553_6098.0593.0DNM2 and WASL
TgeneFNBP1chr9:132816352chr9:132757237ENST00000446176017553_6098.0618.0DNM2 and WASL
TgeneFNBP1chr9:132816352chr9:132757237ENST00000355681016553_6108.0593.0FASLG
TgeneFNBP1chr9:132816352chr9:132757237ENST00000446176017553_6108.0618.0FASLG
TgeneFNBP1chr9:132816352chr9:132757237ENST00000355681016495_6178.0593.0PDE6G
TgeneFNBP1chr9:132816352chr9:132757237ENST00000446176017495_6178.0618.0PDE6G
TgeneFNBP1chr9:132816352chr9:132757237ENST00000355681016400_5528.0593.0RND2
TgeneFNBP1chr9:132816352chr9:132757237ENST00000446176017400_5528.0618.0RND2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneFNBP1chr9:132816352chr9:132757237ENST000003556810161_3358.0593.0microtubules
TgeneFNBP1chr9:132816352chr9:132757237ENST000004461760171_3358.0618.0microtubules


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GPR107-FNBP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GPR107-FNBP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource