Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GPR124-WRN (FusionGDB2 ID:34366)

Fusion Gene Summary for GPR124-WRN

Fusion gene summary

Fusion gene information	Fusion gene name: GPR124-WRN
	Fusion gene ID: 34366
		Hgene	Tgene
	Gene symbol	GPR124	WRN
	Gene ID	25960	7486
	Gene name	adhesion G protein-coupled receptor A2	WRN RecQ like helicase
	Synonyms	GPR124\|TEM5	RECQ3\|RECQL2\|RECQL3
	Cytomap	8p11.23	8p12
	Type of gene	protein-coding	protein-coding
	Description	adhesion G protein-coupled receptor A2G-protein coupled receptor 124tumor endothelial marker 5	Werner syndrome ATP-dependent helicaseDNA helicase, RecQ-like type 3Werner syndrome RecQ like helicaseWerner syndrome, RecQ helicase-likeexonuclease WRNrecQ protein-like 2
	Modification date	20200313	20200320
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000315215, ENST00000412232,	ENST00000298139,
Fusion gene scores	* DoF score	3 X 3 X 2=18	9 X 10 X 7=630
	# samples	3	11
	** MAII score	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(11/630*10)=-2.51784830486262 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GPR124 [Title/Abstract] AND WRN [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GPR124(37655052)-WRN(30938383), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GPR124	GO:0090263	positive regulation of canonical Wnt signaling pathway	30026314
Tgene	WRN	GO:0000731	DNA synthesis involved in DNA repair	17563354
Tgene	WRN	GO:0006259	DNA metabolic process	16622405
Tgene	WRN	GO:0006284	base-excision repair	17611195
Tgene	WRN	GO:0006974	cellular response to DNA damage stimulus	18203716
Tgene	WRN	GO:0006979	response to oxidative stress	17611195
Tgene	WRN	GO:0009267	cellular response to starvation	11420665
Tgene	WRN	GO:0010225	response to UV-C	17563354
Tgene	WRN	GO:0031297	replication fork processing	17115688
Tgene	WRN	GO:0032508	DNA duplex unwinding	11735402\|26420422
Tgene	WRN	GO:0044806	G-quadruplex DNA unwinding	11735402
Tgene	WRN	GO:0051345	positive regulation of hydrolase activity	17611195
Tgene	WRN	GO:0061820	telomeric D-loop disassembly	15200954\|19734539\|26420422
Tgene	WRN	GO:0071480	cellular response to gamma radiation	21639834
Tgene	WRN	GO:0098530	positive regulation of strand invasion	26420422
Tgene	WRN	GO:1902570	protein localization to nucleolus	11420665

Fusion gene breakpoints across GPR124 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across WRN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-HU-A4GJ-01A	GPR124	chr8	37655052	+	WRN	chr8	30938383	+

Top

Fusion Gene ORF analysis for GPR124-WRN

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000315215	ENST00000298139	GPR124	chr8	37655052	+	WRN	chr8	30938383	+
In-frame	ENST00000412232	ENST00000298139	GPR124	chr8	37655052	+	WRN	chr8	30938383	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000315215

GPR124

chr8

37655052

ENST00000298139

WRN

chr8

30938383

4756

629

276

4088

1270

ENST00000412232

GPR124

chr8

37655052

ENST00000298139

WRN

chr8

30938383

4406

279

3738

1242

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000315215	ENST00000298139	GPR124	chr8	37655052	+	WRN	chr8	30938383	+	0.000169383	0.9998306
ENST00000412232	ENST00000298139	GPR124	chr8	37655052	+	WRN	chr8	30938383	+	0.000107617	0.99989235

Top

Fusion Genomic Features for GPR124-WRN

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
GPR124	chr8	37655052	+	WRN	chr8	30938382	+	0.3488811	0.6511189
GPR124	chr8	37655052	+	WRN	chr8	30938382	+	0.3488811	0.6511189

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for GPR124-WRN

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:37655052/chr8:30938383)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

WRN

chr8:37655052

chr8:30938383

ENST00000298139

507_510

279

1433.0

Compositional bias

Note=Poly-Glu

Tgene

WRN

chr8:37655052

chr8:30938383

ENST00000298139

1150_1229

279

1433.0

Domain

HRDC

Tgene

WRN

chr8:37655052

chr8:30938383

ENST00000298139

558_724

279

1433.0

Domain

Helicase ATP-binding

Tgene

WRN

chr8:37655052

chr8:30938383

ENST00000298139

749_899

279

1433.0

Domain

Helicase C-terminal

Tgene

WRN

chr8:37655052

chr8:30938383

ENST00000298139

668_671

279

1433.0

Motif

Note=DEAH box

Tgene

WRN

chr8:37655052

chr8:30938383

ENST00000298139

571_578

279

1433.0

Nucleotide binding

ATP

Tgene

WRN

chr8:37655052

chr8:30938383

ENST00000298139

424_477

279

1433.0

Region

Note=2 X 27 AA tandem repeats of H-L-S-P-N-D-N-E-N-D-T-S-Y-V-I-E-S-D-E-D-L-E-M-E-M-L-K

Tgene

WRN

chr8:37655052

chr8:30938383

ENST00000298139

424_450

279

1433.0

Repeat

Tgene

WRN

chr8:37655052

chr8:30938383

ENST00000298139

451_477

279

1433.0

Repeat

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000315215

190_240

1122.0

Domain

LRRCT

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000315215

247_344

1122.0

Domain

Ig-like

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000315215

707_758

1122.0

Domain

GPS

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000412232

190_240

1339.0

Domain

LRRCT

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000412232

247_344

1339.0

Domain

Ig-like

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000412232

707_758

1339.0

Domain

GPS

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000315215

362_364

1122.0

Motif

RGD

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000412232

362_364

1339.0

Motif

RGD

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000315215

107_130

1122.0

Repeat

LRR 2

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000315215

131_154

1122.0

Repeat

LRR 3

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000315215

156_178

1122.0

Repeat

LRR 4

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000315215

82_106

1122.0

Repeat

LRR 1

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000412232

107_130

1339.0

Repeat

LRR 2

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000412232

131_154

1339.0

Repeat

LRR 3

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000412232

156_178

1339.0

Repeat

LRR 4

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000412232

82_106

1339.0

Repeat

LRR 1

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000315215

1041_1047

1122.0

Topological domain

Extracellular

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000315215

1069_1338

1122.0

Topological domain

Cytoplasmic

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000315215

34_771

1122.0

Topological domain

Extracellular

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000315215

793_807

1122.0

Topological domain

Cytoplasmic

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000315215

829_832

1122.0

Topological domain

Extracellular

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000315215

854_886

1122.0

Topological domain

Cytoplasmic

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000315215

908_924

1122.0

Topological domain

Extracellular

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000315215

946_1019

1122.0

Topological domain

Cytoplasmic

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000412232

1041_1047

1339.0

Topological domain

Extracellular

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000412232

1069_1338

1339.0

Topological domain

Cytoplasmic

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000412232

34_771

1339.0

Topological domain

Extracellular

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000412232

793_807

1339.0

Topological domain

Cytoplasmic

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000412232

829_832

1339.0

Topological domain

Extracellular

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000412232

854_886

1339.0

Topological domain

Cytoplasmic

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000412232

908_924

1339.0

Topological domain

Extracellular

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000412232

946_1019

1339.0

Topological domain

Cytoplasmic

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000315215

1020_1040

1122.0

Transmembrane

Helical%3B Name%3D6

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000315215

1048_1068

1122.0

Transmembrane

Helical%3B Name%3D7

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000315215

772_792

1122.0

Transmembrane

Helical%3B Name%3D1

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000315215

808_828

1122.0

Transmembrane

Helical%3B Name%3D2

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000315215

833_853

1122.0

Transmembrane

Helical%3B Name%3D3

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000315215

887_907

1122.0

Transmembrane

Helical%3B Name%3D4

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000315215

925_945

1122.0

Transmembrane

Helical%3B Name%3D5

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000412232

1020_1040

1339.0

Transmembrane

Helical%3B Name%3D6

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000412232

1048_1068

1339.0

Transmembrane

Helical%3B Name%3D7

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000412232

772_792

1339.0

Transmembrane

Helical%3B Name%3D1

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000412232

808_828

1339.0

Transmembrane

Helical%3B Name%3D2

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000412232

833_853

1339.0

Transmembrane

Helical%3B Name%3D3

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000412232

887_907

1339.0

Transmembrane

Helical%3B Name%3D4

Hgene

GPR124

chr8:37655052

chr8:30938383

ENST00000412232

925_945

1339.0

Transmembrane

Helical%3B Name%3D5

Tgene

WRN

chr8:37655052

chr8:30938383

ENST00000298139

60_228

279

1433.0

Domain

Note=3'-5' exonuclease

Top

Fusion Gene Sequence for GPR124-WRN

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>34366_34366_1_GPR124-WRN_GPR124_chr8_37655052_ENST00000315215_WRN_chr8_30938383_ENST00000298139_length(transcript)=4756nt_BP=629nt
GCGGCGGCAGCAGGAGCCCGGCGCGATCCGCTAGGTCCCAGCCCAGCGCCCAGCGAGCAGGCGACGCGGAGGGGCCGGGCCTCCAGTGTC
CCGAGGGCCGGGCGCTGAGACTCCGGCCGCGCAGCTGGGAGCTGCCCGCGCTGCGCTGACAGCCGCGCCGACGTCCTCCCCGCCGGGGCG
CTCGCAGGACATGCCCCCGGGGCGCGGCGGCGGGGACCCCGGGGCTCGCCTCCGCCCAGGGCCCCCCTCCACGCCCTCGGGAGCCCCGGG
CCCCCGCTGAGCACTCCTCCCGCACGCCTGGGTCCCTCCGGCCGGCGCGCAGCCCGGCCCCAGCGCTGTGGGTCCCCGCGGGGCGATGGG
TTGATGGGCGCCGGGGGACGCAGGATGCGGGGGGCGCCCGCGCGCCTGCTGCTGCCGCTGCTGCCGTGGCTCCTGCTGCTCCTGGCGCCC
GAGGCTCGGGGCGCGCCCGGCTGCCCGCTATCCATCCGCAGCTGCAAGTGCTCGGGGGAGCGGCCCAAGGGGCTGAGCGGCGGCGTCCCT
GGCCCGGCTCGGCGGAGGGTGGTGTGCAGCGGCGGGGACCTCCCGGAGCCTCCCGAGCCCGGCCTTCTGCCTAACGGCACCGTTACCCTG
GTTTCTATCTTACTAAAGGATATTTCAGAAAATCTATATTCACTGAGGAGGATGATAATTGGGTCTACTAACATTGAGACTGAACTGAGG
CCCAGCAATAATTTAAACTTATTATCCTTTGAAGATTCAACTACTGGGGGAGTACAACAGAAACAAATTAGAGAACATGAAGTTTTAATT
CACGTTGAAGATGAAACATGGGACCCAACACTTGATCATTTAGCTAAACATGATGGAGAAGATGTACTTGGAAATAAAGTGGAACGAAAA
GAAGATGGATTTGAAGATGGAGTAGAAGACAACAAATTGAAAGAGAATATGGAAAGAGCTTGTTTGATGTCGTTAGATATTACAGAACAT
GAACTCCAAATTTTGGAACAGCAGTCTCAGGAAGAATATCTTAGTGATATTGCTTATAAATCTACTGAGCATTTATCTCCCAATGATAAT
GAAAACGATACGTCCTATGTAATTGAGAGTGATGAAGATTTAGAAATGGAGATGCTTAAGCATTTATCTCCCAATGATAATGAAAACGAT
ACGTCCTATGTAATTGAGAGTGATGAAGATTTAGAAATGGAGATGCTTAAGTCTTTAGAAAACCTCAATAGTGGCACGGTAGAACCAACT
CATTCTAAATGCTTAAAAATGGAAAGAAATCTGGGTCTTCCTACTAAAGAAGAAGAAGAAGATGATGAAAATGAAGCTAATGAAGGGGAA
GAAGATGATGATAAGGACTTTTTGTGGCCAGCACCCAATGAAGAGCAAGTTACTTGCCTCAAGATGTACTTTGGCCATTCCAGTTTTAAA
CCAGTTCAGTGGAAAGTGATTCATTCAGTATTAGAAGAAAGAAGAGATAATGTTGCTGTCATGGCAACTGGATATGGAAAGAGTTTGTGC
TTCCAGTATCCACCTGTTTATGTAGGCAAGATTGGCCTTGTTATCTCTCCCCTTATTTCTCTGATGGAAGACCAAGTGCTACAGCTTAAA
ATGTCCAACATCCCAGCTTGCTTCCTTGGATCAGCACAGTCAGAAAATGTTCTAACAGATATTAAATTAGGTAAATACCGGATTGTATAC
GTAACTCCAGAATACTGTTCAGGTAACATGGGCCTGCTCCAGCAACTTGAGGCTGATATTGGTATCACGCTCATTGCTGTGGATGAGGCT
CACTGTATTTCTGAGTGGGGGCATGATTTTAGGGATTCATTCAGGAAGTTGGGCTCCCTAAAGACAGCACTGCCAATGGTTCCAATCGTT
GCACTTACTGCTACTGCAAGTTCTTCAATCCGGGAAGACATTGTACGTTGCTTAAATCTGAGAAATCCTCAGATCACCTGTACTGGTTTT
GATCGACCAAACCTGTATTTAGAAGTTAGGCGAAAAACAGGGAATATCCTTCAGGATCTGCAGCCATTTCTTGTCAAAACAAGTTCCCAC
TGGGAATTTGAAGGTCCAACAATCATCTACTGTCCTTCTAGAAAAATGACACAACAAGTTACAGGTGAACTTAGGAAACTGAATCTATCC
TGTGGAACATACCATGCGGGCATGAGTTTTAGCACAAGGAAAGACATTCATCATAGGTTTGTAAGAGATGAAATTCAGTGTGTCATAGCT
ACCATAGCTTTTGGAATGGGCATTAATAAAGCTGACATTCGCCAAGTCATTCATTACGGTGCTCCTAAGGACATGGAATCATATTATCAG
GAGATTGGTAGAGCTGGTCGTGATGGACTTCAAAGTTCTTGTCACGTCCTCTGGGCTCCTGCAGACATTAACTTAAATAGGCACCTTCTT
ACTGAGATACGTAATGAGAAGTTTCGATTATACAAATTAAAGATGATGGCAAAGATGGAAAAATATCTTCATTCTAGCAGATGTAGGAGA
CAAATCATCTTGTCTCATTTTGAGGACAAACAAGTACAAAAAGCCTCCTTGGGAATTATGGGAACTGAAAAATGCTGTGATAATTGCAGG
TCCAGATTGGATCATTGCTATTCCATGGATGACTCAGAGGATACATCCTGGGACTTTGGTCCACAAGCATTTAAGCTTTTGTCTGCTGTG
GACATCTTAGGCGAAAAATTTGGAATTGGGCTTCCAATTTTATTTCTCCGAGGATCTAATTCTCAGCGTCTTGCCGATCAATATCGCAGG
CACAGTTTATTTGGCACTGGCAAGGATCAAACAGAGAGTTGGTGGAAGGCTTTTTCCCGTCAGCTGATCACTGAGGGATTCTTGGTAGAA
GTTTCTCGGTATAACAAATTTATGAAGATTTGCGCCCTTACGAAAAAGGGTAGAAATTGGCTTCATAAAGCTAATACAGAATCTCAGAGC
CTCATCCTTCAAGCTAATGAAGAATTGTGTCCAAAGAAGTTGCTTCTGCCTAGTTCGAAAACTGTATCTTCGGGCACCAAAGAGCATTGT
TATAATCAAGTACCAGTTGAATTAAGTACAGAGAAGAAGTCTAACTTGGAGAAGTTATATTCTTATAAACCATGTGATAAGATTTCTTCT
GGGAGTAACATTTCTAAAAAAAGTATCATGGTACAGTCACCAGAAAAAGCTTACAGTTCCTCACAGCCTGTTATTTCGGCACAAGAGCAG
GAGACTCAGATTGTGTTATATGGCAAATTGGTAGAAGCTAGGCAGAAACATGCCAATAAAATGGATGTTCCCCCAGCTATTCTGGCAACA
AACAAGATACTGGTGGATATGGCCAAAATGAGACCAACTACGGTTGAAAACGTAAAAAGGATTGATGGTGTTTCTGAAGGCAAAGCTGCC
ATGTTGGCCCCTCTGTTGGAAGTCATCAAACATTTCTGCCAAACAAATAGTGTTCAGACAGACCTCTTTTCAAGTACAAAACCTCAAGAA
GAACAGAAGACGAGTCTGGTAGCAAAAAATAAAATATGCACACTTTCACAGTCTATGGCCATCACATACTCTTTATTCCAAGAAAAGAAG
ATGCCTTTGAAGAGCATAGCTGAGAGCAGGATTCTGCCTCTCATGACAATTGGCATGCACTTATCCCAAGCGGTGAAAGCTGGCTGCCCC
CTTGATTTGGAGCGAGCAGGCCTGACTCCAGAGGTTCAGAAGATTATTGCTGATGTTATCCGAAACCCTCCCGTCAACTCAGATATGAGT
AAAATTAGCCTAATCAGAATGTTAGTTCCTGAAAACATTGACACGTACCTTATCCACATGGCAATTGAGATCCTTAAACATGGTCCTGAC
AGCGGACTTCAACCTTCATGTGATGTCAACAAAAGGAGATGTTTTCCCGGTTCTGAAGAGATCTGTTCAAGTTCTAAGAGAAGCAAGGAA
GAAGTAGGCATCAATACTGAGACTTCATCTGCAGAGAGAAAGAGACGATTACCTGTGTGGTTTGCCAAAGGAAGTGATACCAGCAAGAAA
TTAATGGACAAAACGAAAAGGGGAGGTCTTTTTAGTTAAGCTGGCAATTACCAGAACAATTATGTTTCTTGCTGTATTATAAGAGGATAG
CTATATTTTATTTCTGAAGAGTAAGGAGTAGTATTTTGGCTTAAAAATCATTCTAATTACAAAGTTCACTGTTTATTGAAGAACTGGCAT
CTTAAATCAGCCTTCCGCAATTCATGTAGTTTCTGGGTCTTCTGGGAGCCTACGTGAGTACATCACCTAACAGAATATTAAATTAGACTT
CCTGTAAGATTGCTTTAAGAAACTGTTACTGTCCTGTTTTCTAATCTCTTTATTAAAACAGTGTATTTGGAAAATGTTATGTGCTCTGAT
TTGATATAGATAACAGATTAGTAGTTACATGGTAATTATGTGATATAAAATATTCATATATTATCAAAATTCTGTTTTGTAAATGTAAGA
AAGCATAGTTATTTTACAAATTGTTTTTACTGTCTTTTGAAGAAGTTCTTAAATACGTTGTTAAATGGTATTAGTTGACCAGGGCAGTGA
AAATGAAACCGCATTTTGGGTGCCATTAAATAGGGAAAAAACATGTAAAAAATGTAAAATGGAGACCAATTGCACTAGGCAAGTGTATAT

>34366_34366_1_GPR124-WRN_GPR124_chr8_37655052_ENST00000315215_WRN_chr8_30938383_ENST00000298139_length(amino acids)=1270AA_BP=118
MSTPPARLGPSGRRAARPQRCGSPRGDGLMGAGGRRMRGAPARLLLPLLPWLLLLLAPEARGAPGCPLSIRSCKCSGERPKGLSGGVPGP
ARRRVVCSGGDLPEPPEPGLLPNGTVTLVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHV
EDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNEN
DTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEED
DDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMS
NIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVAL
TATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCG
TYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTE
IRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDI
LGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLI
LQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQET
QIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQ
KTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKI
SLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLM

--------------------------------------------------------------
>34366_34366_2_GPR124-WRN_GPR124_chr8_37655052_ENST00000412232_WRN_chr8_30938383_ENST00000298139_length(transcript)=4406nt_BP=279nt
GGGCGATGGGTTGATGGGCGCCGGGGGACGCAGGATGCGGGGGGCGCCCGCGCGCCTGCTGCTGCCGCTGCTGCCGTGGCTCCTGCTGCT
CCTGGCGCCCGAGGCTCGGGGCGCGCCCGGCTGCCCGCTATCCATCCGCAGCTGCAAGTGCTCGGGGGAGCGGCCCAAGGGGCTGAGCGG
CGGCGTCCCTGGCCCGGCTCGGCGGAGGGTGGTGTGCAGCGGCGGGGACCTCCCGGAGCCTCCCGAGCCCGGCCTTCTGCCTAACGGCAC
CGTTACCCTGGTTTCTATCTTACTAAAGGATATTTCAGAAAATCTATATTCACTGAGGAGGATGATAATTGGGTCTACTAACATTGAGAC
TGAACTGAGGCCCAGCAATAATTTAAACTTATTATCCTTTGAAGATTCAACTACTGGGGGAGTACAACAGAAACAAATTAGAGAACATGA
AGTTTTAATTCACGTTGAAGATGAAACATGGGACCCAACACTTGATCATTTAGCTAAACATGATGGAGAAGATGTACTTGGAAATAAAGT
GGAACGAAAAGAAGATGGATTTGAAGATGGAGTAGAAGACAACAAATTGAAAGAGAATATGGAAAGAGCTTGTTTGATGTCGTTAGATAT
TACAGAACATGAACTCCAAATTTTGGAACAGCAGTCTCAGGAAGAATATCTTAGTGATATTGCTTATAAATCTACTGAGCATTTATCTCC
CAATGATAATGAAAACGATACGTCCTATGTAATTGAGAGTGATGAAGATTTAGAAATGGAGATGCTTAAGCATTTATCTCCCAATGATAA
TGAAAACGATACGTCCTATGTAATTGAGAGTGATGAAGATTTAGAAATGGAGATGCTTAAGTCTTTAGAAAACCTCAATAGTGGCACGGT
AGAACCAACTCATTCTAAATGCTTAAAAATGGAAAGAAATCTGGGTCTTCCTACTAAAGAAGAAGAAGAAGATGATGAAAATGAAGCTAA
TGAAGGGGAAGAAGATGATGATAAGGACTTTTTGTGGCCAGCACCCAATGAAGAGCAAGTTACTTGCCTCAAGATGTACTTTGGCCATTC
CAGTTTTAAACCAGTTCAGTGGAAAGTGATTCATTCAGTATTAGAAGAAAGAAGAGATAATGTTGCTGTCATGGCAACTGGATATGGAAA
GAGTTTGTGCTTCCAGTATCCACCTGTTTATGTAGGCAAGATTGGCCTTGTTATCTCTCCCCTTATTTCTCTGATGGAAGACCAAGTGCT
ACAGCTTAAAATGTCCAACATCCCAGCTTGCTTCCTTGGATCAGCACAGTCAGAAAATGTTCTAACAGATATTAAATTAGGTAAATACCG
GATTGTATACGTAACTCCAGAATACTGTTCAGGTAACATGGGCCTGCTCCAGCAACTTGAGGCTGATATTGGTATCACGCTCATTGCTGT
GGATGAGGCTCACTGTATTTCTGAGTGGGGGCATGATTTTAGGGATTCATTCAGGAAGTTGGGCTCCCTAAAGACAGCACTGCCAATGGT
TCCAATCGTTGCACTTACTGCTACTGCAAGTTCTTCAATCCGGGAAGACATTGTACGTTGCTTAAATCTGAGAAATCCTCAGATCACCTG
TACTGGTTTTGATCGACCAAACCTGTATTTAGAAGTTAGGCGAAAAACAGGGAATATCCTTCAGGATCTGCAGCCATTTCTTGTCAAAAC
AAGTTCCCACTGGGAATTTGAAGGTCCAACAATCATCTACTGTCCTTCTAGAAAAATGACACAACAAGTTACAGGTGAACTTAGGAAACT
GAATCTATCCTGTGGAACATACCATGCGGGCATGAGTTTTAGCACAAGGAAAGACATTCATCATAGGTTTGTAAGAGATGAAATTCAGTG
TGTCATAGCTACCATAGCTTTTGGAATGGGCATTAATAAAGCTGACATTCGCCAAGTCATTCATTACGGTGCTCCTAAGGACATGGAATC
ATATTATCAGGAGATTGGTAGAGCTGGTCGTGATGGACTTCAAAGTTCTTGTCACGTCCTCTGGGCTCCTGCAGACATTAACTTAAATAG
GCACCTTCTTACTGAGATACGTAATGAGAAGTTTCGATTATACAAATTAAAGATGATGGCAAAGATGGAAAAATATCTTCATTCTAGCAG
ATGTAGGAGACAAATCATCTTGTCTCATTTTGAGGACAAACAAGTACAAAAAGCCTCCTTGGGAATTATGGGAACTGAAAAATGCTGTGA
TAATTGCAGGTCCAGATTGGATCATTGCTATTCCATGGATGACTCAGAGGATACATCCTGGGACTTTGGTCCACAAGCATTTAAGCTTTT
GTCTGCTGTGGACATCTTAGGCGAAAAATTTGGAATTGGGCTTCCAATTTTATTTCTCCGAGGATCTAATTCTCAGCGTCTTGCCGATCA
ATATCGCAGGCACAGTTTATTTGGCACTGGCAAGGATCAAACAGAGAGTTGGTGGAAGGCTTTTTCCCGTCAGCTGATCACTGAGGGATT
CTTGGTAGAAGTTTCTCGGTATAACAAATTTATGAAGATTTGCGCCCTTACGAAAAAGGGTAGAAATTGGCTTCATAAAGCTAATACAGA
ATCTCAGAGCCTCATCCTTCAAGCTAATGAAGAATTGTGTCCAAAGAAGTTGCTTCTGCCTAGTTCGAAAACTGTATCTTCGGGCACCAA
AGAGCATTGTTATAATCAAGTACCAGTTGAATTAAGTACAGAGAAGAAGTCTAACTTGGAGAAGTTATATTCTTATAAACCATGTGATAA
GATTTCTTCTGGGAGTAACATTTCTAAAAAAAGTATCATGGTACAGTCACCAGAAAAAGCTTACAGTTCCTCACAGCCTGTTATTTCGGC
ACAAGAGCAGGAGACTCAGATTGTGTTATATGGCAAATTGGTAGAAGCTAGGCAGAAACATGCCAATAAAATGGATGTTCCCCCAGCTAT
TCTGGCAACAAACAAGATACTGGTGGATATGGCCAAAATGAGACCAACTACGGTTGAAAACGTAAAAAGGATTGATGGTGTTTCTGAAGG
CAAAGCTGCCATGTTGGCCCCTCTGTTGGAAGTCATCAAACATTTCTGCCAAACAAATAGTGTTCAGACAGACCTCTTTTCAAGTACAAA
ACCTCAAGAAGAACAGAAGACGAGTCTGGTAGCAAAAAATAAAATATGCACACTTTCACAGTCTATGGCCATCACATACTCTTTATTCCA
AGAAAAGAAGATGCCTTTGAAGAGCATAGCTGAGAGCAGGATTCTGCCTCTCATGACAATTGGCATGCACTTATCCCAAGCGGTGAAAGC
TGGCTGCCCCCTTGATTTGGAGCGAGCAGGCCTGACTCCAGAGGTTCAGAAGATTATTGCTGATGTTATCCGAAACCCTCCCGTCAACTC
AGATATGAGTAAAATTAGCCTAATCAGAATGTTAGTTCCTGAAAACATTGACACGTACCTTATCCACATGGCAATTGAGATCCTTAAACA
TGGTCCTGACAGCGGACTTCAACCTTCATGTGATGTCAACAAAAGGAGATGTTTTCCCGGTTCTGAAGAGATCTGTTCAAGTTCTAAGAG
AAGCAAGGAAGAAGTAGGCATCAATACTGAGACTTCATCTGCAGAGAGAAAGAGACGATTACCTGTGTGGTTTGCCAAAGGAAGTGATAC
CAGCAAGAAATTAATGGACAAAACGAAAAGGGGAGGTCTTTTTAGTTAAGCTGGCAATTACCAGAACAATTATGTTTCTTGCTGTATTAT
AAGAGGATAGCTATATTTTATTTCTGAAGAGTAAGGAGTAGTATTTTGGCTTAAAAATCATTCTAATTACAAAGTTCACTGTTTATTGAA
GAACTGGCATCTTAAATCAGCCTTCCGCAATTCATGTAGTTTCTGGGTCTTCTGGGAGCCTACGTGAGTACATCACCTAACAGAATATTA
AATTAGACTTCCTGTAAGATTGCTTTAAGAAACTGTTACTGTCCTGTTTTCTAATCTCTTTATTAAAACAGTGTATTTGGAAAATGTTAT
GTGCTCTGATTTGATATAGATAACAGATTAGTAGTTACATGGTAATTATGTGATATAAAATATTCATATATTATCAAAATTCTGTTTTGT
AAATGTAAGAAAGCATAGTTATTTTACAAATTGTTTTTACTGTCTTTTGAAGAAGTTCTTAAATACGTTGTTAAATGGTATTAGTTGACC
AGGGCAGTGAAAATGAAACCGCATTTTGGGTGCCATTAAATAGGGAAAAAACATGTAAAAAATGTAAAATGGAGACCAATTGCACTAGGC

>34366_34366_2_GPR124-WRN_GPR124_chr8_37655052_ENST00000412232_WRN_chr8_30938383_ENST00000298139_length(amino acids)=1242AA_BP=90
MMGAGGRRMRGAPARLLLPLLPWLLLLLAPEARGAPGCPLSIRSCKCSGERPKGLSGGVPGPARRRVVCSGGDLPEPPEPGLLPNGTVTL
VSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERK
EDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNEND
TSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFK
PVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVY
VTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGF
DRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIA
TIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRR
QIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRR
HSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHC
YNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILAT
NKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKK
MPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPD

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for GPR124-WRN

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	WRN	chr8:37655052	chr8:30938383	ENST00000298139		7	35	987_993	279.6666666666667	1433.0	DNA

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	WRN	chr8:37655052	chr8:30938383	ENST00000298139		7	35	2_277	279.6666666666667	1433.0	WRNIP1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GPR124-WRN

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for GPR124-WRN

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source