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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GPR125-DNER (FusionGDB2 ID:34367)

Fusion Gene Summary for GPR125-DNER

check button Fusion gene summary
Fusion gene informationFusion gene name: GPR125-DNER
Fusion gene ID: 34367
HgeneTgene
Gene symbol

GPR125

DNER

Gene ID

166647

92737

Gene nameadhesion G protein-coupled receptor A3delta/notch like EGF repeat containing
SynonymsGPR125|PGR21|TEM5LUNQ26|bet
Cytomap

4p15.2

2q36.3

Type of geneprotein-codingprotein-coding
Descriptionadhesion G protein-coupled receptor A3G-protein coupled receptor 125probable G-protein coupled receptor 125delta and Notch-like epidermal growth factor-related receptorH_NH0150O02.1WUGSC:H_NH0150O02.1delta-notch-like EGF repeat-containing transmembrane
Modification date2020031320200313
UniProtAcc.

Q8NFT8

Ensembl transtripts involved in fusion geneENST00000334304, ENST00000502482, 
ENST00000508133, ENST00000282943, 
ENST00000482831, ENST00000341772, 
Fusion gene scores* DoF score2 X 2 X 2=85 X 3 X 4=60
# samples 27
** MAII scorelog2(2/8*10)=1.32192809488736log2(7/60*10)=0.222392421336448
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GPR125 [Title/Abstract] AND DNER [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGPR125(22425814)-DNER(230456604), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across GPR125 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DNER (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-12-0618-01AGPR125chr4

22425814

-DNERchr2

230456604

-


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Fusion Gene ORF analysis for GPR125-DNER

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000334304ENST00000482831GPR125chr4

22425814

-DNERchr2

230456604

-
5CDS-intronENST00000502482ENST00000482831GPR125chr4

22425814

-DNERchr2

230456604

-
5CDS-intronENST00000508133ENST00000482831GPR125chr4

22425814

-DNERchr2

230456604

-
5UTR-3CDSENST00000282943ENST00000341772GPR125chr4

22425814

-DNERchr2

230456604

-
5UTR-intronENST00000282943ENST00000482831GPR125chr4

22425814

-DNERchr2

230456604

-
In-frameENST00000334304ENST00000341772GPR125chr4

22425814

-DNERchr2

230456604

-
In-frameENST00000502482ENST00000341772GPR125chr4

22425814

-DNERchr2

230456604

-
In-frameENST00000508133ENST00000341772GPR125chr4

22425814

-DNERchr2

230456604

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000334304GPR125chr422425814-ENST00000341772DNERchr2230456604-4724187527038121180
ENST00000508133GPR125chr422425814-ENST00000341772DNERchr2230456604-3804955282892954
ENST00000502482GPR125chr422425814-ENST00000341772DNERchr2230456604-4667181821337551180

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000334304ENST00000341772GPR125chr422425814-DNERchr2230456604-0.0004515210.9995485
ENST00000508133ENST00000341772GPR125chr422425814-DNERchr2230456604-0.0002680220.99973196
ENST00000502482ENST00000341772GPR125chr422425814-DNERchr2230456604-0.0004222330.9995778

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Fusion Genomic Features for GPR125-DNER


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GPR125-DNER


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:22425814/chr2:230456604)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DNER

Q8NFT8

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGPR125chr4:22425814chr2:230456604ENST00000334304-1119187_2375351322.0DomainNote=LRRCT
HgeneGPR125chr4:22425814chr2:230456604ENST00000334304-1119242_3405351322.0DomainNote=Ig-like
HgeneGPR125chr4:22425814chr2:230456604ENST00000502482-1112187_237535617.0DomainNote=LRRCT
HgeneGPR125chr4:22425814chr2:230456604ENST00000502482-1112242_340535617.0DomainNote=Ig-like
HgeneGPR125chr4:22425814chr2:230456604ENST00000508133-68187_237309382.0DomainNote=LRRCT
HgeneGPR125chr4:22425814chr2:230456604ENST00000334304-1119106_1275351322.0RepeatNote=LRR 2
HgeneGPR125chr4:22425814chr2:230456604ENST00000334304-1119130_1515351322.0RepeatNote=LRR 3
HgeneGPR125chr4:22425814chr2:230456604ENST00000334304-1119154_1755351322.0RepeatNote=LRR 4
HgeneGPR125chr4:22425814chr2:230456604ENST00000334304-111982_1035351322.0RepeatNote=LRR 1
HgeneGPR125chr4:22425814chr2:230456604ENST00000502482-1112106_127535617.0RepeatNote=LRR 2
HgeneGPR125chr4:22425814chr2:230456604ENST00000502482-1112130_151535617.0RepeatNote=LRR 3
HgeneGPR125chr4:22425814chr2:230456604ENST00000502482-1112154_175535617.0RepeatNote=LRR 4
HgeneGPR125chr4:22425814chr2:230456604ENST00000502482-111282_103535617.0RepeatNote=LRR 1
HgeneGPR125chr4:22425814chr2:230456604ENST00000508133-68106_127309382.0RepeatNote=LRR 2
HgeneGPR125chr4:22425814chr2:230456604ENST00000508133-68130_151309382.0RepeatNote=LRR 3
HgeneGPR125chr4:22425814chr2:230456604ENST00000508133-68154_175309382.0RepeatNote=LRR 4
HgeneGPR125chr4:22425814chr2:230456604ENST00000508133-6882_103309382.0RepeatNote=LRR 1
TgeneDNERchr4:22425814chr2:230456604ENST00000341772013309_34892738.0DomainEGF-like 3
TgeneDNERchr4:22425814chr2:230456604ENST00000341772013349_39092738.0DomainEGF-like 4
TgeneDNERchr4:22425814chr2:230456604ENST00000341772013392_42892738.0DomainEGF-like 5
TgeneDNERchr4:22425814chr2:230456604ENST00000341772013430_46692738.0DomainEGF-like 6
TgeneDNERchr4:22425814chr2:230456604ENST00000341772013468_50392738.0DomainEGF-like 7
TgeneDNERchr4:22425814chr2:230456604ENST00000341772013505_54192738.0DomainEGF-like 8%3B calcium-binding
TgeneDNERchr4:22425814chr2:230456604ENST00000341772013543_57992738.0DomainEGF-like 9
TgeneDNERchr4:22425814chr2:230456604ENST00000341772013546_56892738.0DomainNote=Follistatin-like
TgeneDNERchr4:22425814chr2:230456604ENST00000341772013581_61792738.0DomainEGF-like 10%3B calcium-binding
TgeneDNERchr4:22425814chr2:230456604ENST0000034177201394_13392738.0DomainEGF-like 2
TgeneDNERchr4:22425814chr2:230456604ENST00000341772013662_73792738.0Topological domainCytoplasmic
TgeneDNERchr4:22425814chr2:230456604ENST00000341772013641_66192738.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGPR125chr4:22425814chr2:230456604ENST00000334304-1119698_7495351322.0DomainGPS
HgeneGPR125chr4:22425814chr2:230456604ENST00000502482-1112698_749535617.0DomainGPS
HgeneGPR125chr4:22425814chr2:230456604ENST00000508133-68242_340309382.0DomainNote=Ig-like
HgeneGPR125chr4:22425814chr2:230456604ENST00000508133-68698_749309382.0DomainGPS
HgeneGPR125chr4:22425814chr2:230456604ENST00000334304-11191319_13215351322.0MotifPDZ-binding
HgeneGPR125chr4:22425814chr2:230456604ENST00000502482-11121319_1321535617.0MotifPDZ-binding
HgeneGPR125chr4:22425814chr2:230456604ENST00000508133-681319_1321309382.0MotifPDZ-binding
HgeneGPR125chr4:22425814chr2:230456604ENST00000334304-1119594_6205351322.0RepeatNote=LRR 5
HgeneGPR125chr4:22425814chr2:230456604ENST00000502482-1112594_620535617.0RepeatNote=LRR 5
HgeneGPR125chr4:22425814chr2:230456604ENST00000508133-68594_620309382.0RepeatNote=LRR 5
HgeneGPR125chr4:22425814chr2:230456604ENST00000334304-11191018_10245351322.0Topological domainExtracellular
HgeneGPR125chr4:22425814chr2:230456604ENST00000334304-11191046_13215351322.0Topological domainCytoplasmic
HgeneGPR125chr4:22425814chr2:230456604ENST00000334304-111934_7615351322.0Topological domainExtracellular
HgeneGPR125chr4:22425814chr2:230456604ENST00000334304-1119783_7965351322.0Topological domainCytoplasmic
HgeneGPR125chr4:22425814chr2:230456604ENST00000334304-1119818_8265351322.0Topological domainExtracellular
HgeneGPR125chr4:22425814chr2:230456604ENST00000334304-1119848_8765351322.0Topological domainCytoplasmic
HgeneGPR125chr4:22425814chr2:230456604ENST00000334304-1119898_9195351322.0Topological domainExtracellular
HgeneGPR125chr4:22425814chr2:230456604ENST00000334304-1119941_9965351322.0Topological domainCytoplasmic
HgeneGPR125chr4:22425814chr2:230456604ENST00000502482-11121018_1024535617.0Topological domainExtracellular
HgeneGPR125chr4:22425814chr2:230456604ENST00000502482-11121046_1321535617.0Topological domainCytoplasmic
HgeneGPR125chr4:22425814chr2:230456604ENST00000502482-111234_761535617.0Topological domainExtracellular
HgeneGPR125chr4:22425814chr2:230456604ENST00000502482-1112783_796535617.0Topological domainCytoplasmic
HgeneGPR125chr4:22425814chr2:230456604ENST00000502482-1112818_826535617.0Topological domainExtracellular
HgeneGPR125chr4:22425814chr2:230456604ENST00000502482-1112848_876535617.0Topological domainCytoplasmic
HgeneGPR125chr4:22425814chr2:230456604ENST00000502482-1112898_919535617.0Topological domainExtracellular
HgeneGPR125chr4:22425814chr2:230456604ENST00000502482-1112941_996535617.0Topological domainCytoplasmic
HgeneGPR125chr4:22425814chr2:230456604ENST00000508133-681018_1024309382.0Topological domainExtracellular
HgeneGPR125chr4:22425814chr2:230456604ENST00000508133-681046_1321309382.0Topological domainCytoplasmic
HgeneGPR125chr4:22425814chr2:230456604ENST00000508133-6834_761309382.0Topological domainExtracellular
HgeneGPR125chr4:22425814chr2:230456604ENST00000508133-68783_796309382.0Topological domainCytoplasmic
HgeneGPR125chr4:22425814chr2:230456604ENST00000508133-68818_826309382.0Topological domainExtracellular
HgeneGPR125chr4:22425814chr2:230456604ENST00000508133-68848_876309382.0Topological domainCytoplasmic
HgeneGPR125chr4:22425814chr2:230456604ENST00000508133-68898_919309382.0Topological domainExtracellular
HgeneGPR125chr4:22425814chr2:230456604ENST00000508133-68941_996309382.0Topological domainCytoplasmic
HgeneGPR125chr4:22425814chr2:230456604ENST00000334304-11191025_10455351322.0TransmembraneHelical%3B Name%3D7
HgeneGPR125chr4:22425814chr2:230456604ENST00000334304-1119762_7825351322.0TransmembraneHelical%3B Name%3D1
HgeneGPR125chr4:22425814chr2:230456604ENST00000334304-1119797_8175351322.0TransmembraneHelical%3B Name%3D2
HgeneGPR125chr4:22425814chr2:230456604ENST00000334304-1119827_8475351322.0TransmembraneHelical%3B Name%3D3
HgeneGPR125chr4:22425814chr2:230456604ENST00000334304-1119877_8975351322.0TransmembraneHelical%3B Name%3D4
HgeneGPR125chr4:22425814chr2:230456604ENST00000334304-1119920_9405351322.0TransmembraneHelical%3B Name%3D5
HgeneGPR125chr4:22425814chr2:230456604ENST00000334304-1119997_10175351322.0TransmembraneHelical%3B Name%3D6
HgeneGPR125chr4:22425814chr2:230456604ENST00000502482-11121025_1045535617.0TransmembraneHelical%3B Name%3D7
HgeneGPR125chr4:22425814chr2:230456604ENST00000502482-1112762_782535617.0TransmembraneHelical%3B Name%3D1
HgeneGPR125chr4:22425814chr2:230456604ENST00000502482-1112797_817535617.0TransmembraneHelical%3B Name%3D2
HgeneGPR125chr4:22425814chr2:230456604ENST00000502482-1112827_847535617.0TransmembraneHelical%3B Name%3D3
HgeneGPR125chr4:22425814chr2:230456604ENST00000502482-1112877_897535617.0TransmembraneHelical%3B Name%3D4
HgeneGPR125chr4:22425814chr2:230456604ENST00000502482-1112920_940535617.0TransmembraneHelical%3B Name%3D5
HgeneGPR125chr4:22425814chr2:230456604ENST00000502482-1112997_1017535617.0TransmembraneHelical%3B Name%3D6
HgeneGPR125chr4:22425814chr2:230456604ENST00000508133-681025_1045309382.0TransmembraneHelical%3B Name%3D7
HgeneGPR125chr4:22425814chr2:230456604ENST00000508133-68762_782309382.0TransmembraneHelical%3B Name%3D1
HgeneGPR125chr4:22425814chr2:230456604ENST00000508133-68797_817309382.0TransmembraneHelical%3B Name%3D2
HgeneGPR125chr4:22425814chr2:230456604ENST00000508133-68827_847309382.0TransmembraneHelical%3B Name%3D3
HgeneGPR125chr4:22425814chr2:230456604ENST00000508133-68877_897309382.0TransmembraneHelical%3B Name%3D4
HgeneGPR125chr4:22425814chr2:230456604ENST00000508133-68920_940309382.0TransmembraneHelical%3B Name%3D5
HgeneGPR125chr4:22425814chr2:230456604ENST00000508133-68997_1017309382.0TransmembraneHelical%3B Name%3D6
TgeneDNERchr4:22425814chr2:230456604ENST0000034177201344_9292738.0DomainEGF-like 1
TgeneDNERchr4:22425814chr2:230456604ENST0000034177201335_64092738.0Topological domainExtracellular


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Fusion Gene Sequence for GPR125-DNER


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>34367_34367_1_GPR125-DNER_GPR125_chr4_22425814_ENST00000334304_DNER_chr2_230456604_ENST00000341772_length(transcript)=4724nt_BP=1875nt
GGCGGCGGCAGAGGAGGAGGAGGAGGCGGTGCTCGCGCCGGGCGGTAGAGCGGCGCTGGGACCCATGCGGCCGTGACCCCCGGCTCCCTA
GAGGCCCAGCGCAGCCGCAGCGGACAAAGGAGCATGTCCGCGCCGGGGAAGGCCCGTCCTCCGGCCGCCATAAGGCTCCGGTCGCCGCTG
GGCCCGCGCCGCGCTCCTGCCCGCCCGGGCTCCGGGGCGGCCCGCTAGGCCAGTGCGCCGCCGCTCGCCCCGCAGGCCCCGGCCCGCAGC
ATGGAGCCACCCGGACGCCGGCGGGGCCGCGCGCAGCCGCCGCTGTTGCTGCCGCTCTCGCTGTTAGCGCTGCTCGCGCTGCTGGGAGGC
GGCGGCGGCGGCGGCGCCGCGGCGCTGCCCGCCGGCTGCAAGCACGATGGGCGGCCCCGAGGGGCTGGCAGGGCGGCGGGCGCCGCCGAG
GGCAAGGTGGTGTGCAGCAGCCTGGAACTCGCGCAGGTCCTGCCCCCAGATACTCTGCCCAACCGCACGGTCACCCTGATTCTGAGTAAC
AATAAGATATCCGAGCTGAAGAATGGCTCATTTTCTGGGTTAAGTCTCCTTGAAAGATTGGACCTCCGAAACAATCTTATTAGTAGTATA
GATCCAGGTGCCTTCTGGGGACTGTCATCTCTAAAAAGATTGGATCTGACAAACAATCGAATAGGATGTCTGAATGCAGACATATTTCGA
GGACTCACCAATCTGGTTCGGCTAAACCTTTCGGGGAATTTGTTTTCTTCATTATCTCAAGGAACTTTTGATTATCTTGCGTCATTACGG
TCTTTGGAATTCCAGACTGAGTATCTTTTGTGTGACTGTAACATACTGTGGATGCATCGCTGGGTAAAGGAGAAGAACATCACGGTACGG
GATACCAGGTGTGTTTATCCTAAGTCACTGCAGGCCCAACCAGTCACAGGCGTGAAGCAGGAGCTGTTGACATGCGACCCTCCGCTTGAA
TTGCCGTCTTTCTACATGACTCCATCTCATCGCCAAGTTGTGTTTGAAGGAGACAGCCTTCCTTTCCAGTGCATGGCTTCATATATTGAT
CAGGACATGCAAGTGTTGTGGTATCAGGATGGGAGAATAGTTGAAACCGATGAATCGCAAGGTATTTTTGTTGAAAAGAACATGATTCAC
AACTGCTCCTTGATTGCAAGTGCCCTAACCATTTCTAATATTCAGGCTGGATCTACTGGAAATTGGGGCTGTCATGTCCAGACCAAACGT
GGGAATAATACGAGGACTGTGGATATTGTGGTATTAGAGAGTTCTGCACAGTACTGTCCTCCAGAGAGGGTGGTAAACAACAAAGGTGAC
TTCAGATGGCCCAGAACATTGGCAGGCATTACTGCATATCTGCAGTGTACGCGGAACACCCATGGCAGTGGGATATATCCCGGAAACCCA
CAGGATGAGAGAAAAGCTTGGCGCAGATGTGATAGAGGTGGCTTTTGGGCAGATGATGATTATTCTCGCTGTCAGTATGCAAATGATGTC
ACTAGAGTTCTTTATATGTTTAATCAGATGCCCCTCAATCTTACCAATGCCGTGGCAACAGCTCGACAGTTACTGGCTTACACTGTGGAA
GCAGCCAACTTTTCTGACAAAATGGATGTTATATTTGTGGCAGAAATGATTGAAAAATTTGGAAGATTTACCAAGGAGGAAAAATCAAAA
GAGCTAGGTGACGTGATGGTTGACATTGCAAGTAACATCATGTTGGCTGATGAACGTGTCCTGTGGCTGGCGCAGAGGGAAGCTAAAGCC
TGCAGTAGGATTGTGCAGTGTCTTCAGCGCATTGCTACCTACCGGCTAGCCGGTGGAGCTCACGTTTATTCAACACTTGTTGCAGATCCT
TGTGCCAGCAACCCTTGTCACCATGGCAACTGCAGCAGCAGCAGCAGCAGCAGCAGCGATGGCTACCTCTGCATTTGCAATGAAGGCTAT
GAAGGTCCCAACTGTGAACAGGCACTTCCCAGTCTCCCAGCCACTGGCTGGACCGAATCCATGGCACCCCGACAGCTTCAGCCTGTTCCT
GCTACTCAGGAGCCTGACAAAATCCTGCCTCGCTCTCAGGCAACGGTGACACTGCCTACCTGGCAGCCGAAAACAGGGCAGAAAGTTGTA
GAAATGAAATGGGATCAAGTGGAGGTGATCCCAGATATTGCCTGTGGGAATGCCAGTTCTAACAGCTCTGCGGGTGGCCGCCTGGTATCC
TTTGAAGTGCCACAGAACACCTCAGTCAAGATTCGGCAAGATGCCACTGCCTCACTGATTTTGCTCTGGAAGGTCACGGCCACAGGATTC
CAACAGTGCTCCCTCATAGATGGACGAAGTGTGACCCCCCTTCAGGCTTCAGGGGGACTGGTCCTCCTGGAGGAGATGCTCGCCTTGGGG
AATAATCACTTTATTGGTTTTGTGAATGATTCTGTGACTAAGTCTATTGTGGCTTTGCGCTTAACTCTGGTGGTGAAGGTCAGCACCTGT
GTGCCGGGGGAGAGTCACGCAAATGACTTGGAGTGTTCAGGAAAAGGAAAATGCACCACGAAGCCGTCAGAGGCAACTTTTTCCTGTACC
TGTGAGGAGCAGTACGTGGGTACTTTCTGTGAAGAATACGATGCTTGCCAGAGGAAACCTTGCCAAAACAACGCGAGCTGTATTGATGCA
AATGAAAAGCAAGATGGGAGCAATTTCACCTGTGTTTGCCTTCCTGGTTATACTGGAGAGCTTTGCCAGTCCAAGATTGATTACTGCATC
CTAGACCCATGCAGAAATGGAGCAACATGCATTTCCAGTCTCAGTGGATTCACCTGCCAGTGTCCAGAAGGATACTTCGGATCTGCTTGT
GAAGAAAAGGTGGACCCCTGCGCCTCGTCTCCGTGCCAGAACAACGGCACCTGCTATGTGGACGGGGTACACTTTACCTGCAACTGCAGC
CCGGGCTTCACAGGGCCGACCTGTGCCCAGCTTATTGACTTCTGTGCCCTCAGCCCCTGTGCTCATGGCACGTGCCGCAGCGTGGGCACC
AGCTACAAATGCCTCTGTGATCCAGGTTACCATGGCCTCTACTGTGAGGAGGAATATAATGAGTGCCTCTCCGCTCCATGCCTGAATGCA
GCCACCTGCAGGGACCTCGTTAATGGCTATGAGTGTGTGTGCCTGGCAGAATACAAAGGAACACACTGTGAATTGTACAAGGATCCCTGC
GCTAACGTCAGCTGTCTGAACGGAGCCACCTGTGACAGCGACGGCCTGAATGGCACGTGCATCTGTGCACCCGGGTTTACAGGTGAAGAG
TGCGACATTGACATAAATGAATGTGACAGTAACCCCTGCCACCATGGTGGGAGCTGCCTGGACCAGCCCAATGGTTATAACTGCCACTGC
CCGCATGGTTGGGTGGGAGCAAACTGTGAGATCCACCTCCAATGGAAGTCCGGGCACATGGCGGAGAGCCTCACCAACATGCCACGGCAC
TCCCTCTACATCATCATTGGAGCCCTCTGCGTGGCCTTCATCCTTATGCTGATCATCCTGATCGTGGGGATTTGCCGCATCAGCCGCATT
GAATACCAGGGTTCTTCCAGGCCAGCCTATGAGGAGTTCTACAACTGCCGCAGCATCGACAGCGAGTTCAGCAATGCCATTGCATCCATC
CGGCATGCCAGGTTTGGAAAGAAATCCCGGCCTGCAATGTATGATGTGAGCCCCATCGCCTATGAAGATTACAGTCCTGATGACAAACCC
TTGGTCACACTGATTAAAACTAAAGATTTGTAATCTTTTTTTGGATTATTTTTCAAAAAGATGAGATACTACACTCATTTAAATATTTTT
AAGAAAATAAAAAGCTTAAGAAATTTAAAATGCTAGCTGCTCAAGAGTTTTCAGTAGAATATTTAAGAACTAATTTTCTGCAGCTTTTAG
TTTGGAAAAAATATTTTAAAAACAAAATTTGTGAAACCTATAGACGATGTTTTAATGTACCTTCAGCTCTCTAAACTGTGTGCTTCTACT
AGTGTGTGCTCTTTTCACTGTAGACACTATCACGAGACCCAGATTAATTTCTGTGGTTGTTACAGAATAAGTCTAATCAAGGAGAAGTTT
CTGTTTGACGTTTGAGTGCCGGCTTTCTGAGTAGAGTTAGGAAAACCACGTAACGTAGCATATGATGTATAATAGAGTATACCCGTTACT
TAAAAAGAAGTCTGAAATGTTCGTTTTGTGGAAAAGAAACTAGTTAAATTTACTATTCCTAACCCGAATGAAATTAGCCTTTGCCTTATT
CTGTGCATGGGTAAGTAACTTATTTCTGCACTGTTTTGTTGAACTTTGTGGAAACATTCTTTCGAGTTTGTTTTTGTCATTTTCGTAACA
GTCGTCGAACTAGGCCTCAAAAACATACGTAACGAAAAGGCCTAGCGAGGCAAATTCTGATTGATTTGAATCTATATTTTTCTTTAAAAA
GTCAAGGGTTCTATATTGTGAGTAAATTAAATTTACATTTGAGTTGTTTGTTGCTAAGAGGTAGTAAATGTAAGAGAGTACTGGTTCCTT
CAGTAGTGAGTATTTCTCATAGTGCAGCTTTATTTATCTCCAGGATGTTTTTGTGGCTGTATTTGATTGATATGTGCTTCTTCTGATTCT

>34367_34367_1_GPR125-DNER_GPR125_chr4_22425814_ENST00000334304_DNER_chr2_230456604_ENST00000341772_length(amino acids)=1180AA_BP=535
MEPPGRRRGRAQPPLLLPLSLLALLALLGGGGGGGAAALPAGCKHDGRPRGAGRAAGAAEGKVVCSSLELAQVLPPDTLPNRTVTLILSN
NKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCLNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLR
SLEFQTEYLLCDCNILWMHRWVKEKNITVRDTRCVYPKSLQAQPVTGVKQELLTCDPPLELPSFYMTPSHRQVVFEGDSLPFQCMASYID
QDMQVLWYQDGRIVETDESQGIFVEKNMIHNCSLIASALTISNIQAGSTGNWGCHVQTKRGNNTRTVDIVVLESSAQYCPPERVVNNKGD
FRWPRTLAGITAYLQCTRNTHGSGIYPGNPQDERKAWRRCDRGGFWADDDYSRCQYANDVTRVLYMFNQMPLNLTNAVATARQLLAYTVE
AANFSDKMDVIFVAEMIEKFGRFTKEEKSKELGDVMVDIASNIMLADERVLWLAQREAKACSRIVQCLQRIATYRLAGGAHVYSTLVADP
CASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPATQEPDKILPRSQATVTLPTWQPKTGQKVV
EMKWDQVEVIPDIACGNASSNSSAGGRLVSFEVPQNTSVKIRQDATASLILLWKVTATGFQQCSLIDGRSVTPLQASGGLVLLEEMLALG
NNHFIGFVNDSVTKSIVALRLTLVVKVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDA
NEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCS
PGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPC
ANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHLQWKSGHMAESLTNMPRH
SLYIIIGALCVAFILMLIILIVGICRISRIEYQGSSRPAYEEFYNCRSIDSEFSNAIASIRHARFGKKSRPAMYDVSPIAYEDYSPDDKP

--------------------------------------------------------------
>34367_34367_2_GPR125-DNER_GPR125_chr4_22425814_ENST00000502482_DNER_chr2_230456604_ENST00000341772_length(transcript)=4667nt_BP=1818nt
GGGACCCATGCGGCCGTGACCCCCGGCTCCCTAGAGGCCCAGCGCAGCCGCAGCGGACAAAGGAGCATGTCCGCGCCGGGGAAGGCCCGT
CCTCCGGCCGCCATAAGGCTCCGGTCGCCGCTGGGCCCGCGCCGCGCTCCTGCCCGCCCGGGCTCCGGGGCGGCCCGCTAGGCCAGTGCG
CCGCCGCTCGCCCCGCAGGCCCCGGCCCGCAGCATGGAGCCACCCGGACGCCGGCGGGGCCGCGCGCAGCCGCCGCTGTTGCTGCCGCTC
TCGCTGTTAGCGCTGCTCGCGCTGCTGGGAGGCGGCGGCGGCGGCGGCGCCGCGGCGCTGCCCGCCGGCTGCAAGCACGATGGGCGGCCC
CGAGGGGCTGGCAGGGCGGCGGGCGCCGCCGAGGGCAAGGTGGTGTGCAGCAGCCTGGAACTCGCGCAGGTCCTGCCCCCAGATACTCTG
CCCAACCGCACGGTCACCCTGATTCTGAGTAACAATAAGATATCCGAGCTGAAGAATGGCTCATTTTCTGGGTTAAGTCTCCTTGAAAGA
TTGGACCTCCGAAACAATCTTATTAGTAGTATAGATCCAGGTGCCTTCTGGGGACTGTCATCTCTAAAAAGATTGGATCTGACAAACAAT
CGAATAGGATGTCTGAATGCAGACATATTTCGAGGACTCACCAATCTGGTTCGGCTAAACCTTTCGGGGAATTTGTTTTCTTCATTATCT
CAAGGAACTTTTGATTATCTTGCGTCATTACGGTCTTTGGAATTCCAGACTGAGTATCTTTTGTGTGACTGTAACATACTGTGGATGCAT
CGCTGGGTAAAGGAGAAGAACATCACGGTACGGGATACCAGGTGTGTTTATCCTAAGTCACTGCAGGCCCAACCAGTCACAGGCGTGAAG
CAGGAGCTGTTGACATGCGACCCTCCGCTTGAATTGCCGTCTTTCTACATGACTCCATCTCATCGCCAAGTTGTGTTTGAAGGAGACAGC
CTTCCTTTCCAGTGCATGGCTTCATATATTGATCAGGACATGCAAGTGTTGTGGTATCAGGATGGGAGAATAGTTGAAACCGATGAATCG
CAAGGTATTTTTGTTGAAAAGAACATGATTCACAACTGCTCCTTGATTGCAAGTGCCCTAACCATTTCTAATATTCAGGCTGGATCTACT
GGAAATTGGGGCTGTCATGTCCAGACCAAACGTGGGAATAATACGAGGACTGTGGATATTGTGGTATTAGAGAGTTCTGCACAGTACTGT
CCTCCAGAGAGGGTGGTAAACAACAAAGGTGACTTCAGATGGCCCAGAACATTGGCAGGCATTACTGCATATCTGCAGTGTACGCGGAAC
ACCCATGGCAGTGGGATATATCCCGGAAACCCACAGGATGAGAGAAAAGCTTGGCGCAGATGTGATAGAGGTGGCTTTTGGGCAGATGAT
GATTATTCTCGCTGTCAGTATGCAAATGATGTCACTAGAGTTCTTTATATGTTTAATCAGATGCCCCTCAATCTTACCAATGCCGTGGCA
ACAGCTCGACAGTTACTGGCTTACACTGTGGAAGCAGCCAACTTTTCTGACAAAATGGATGTTATATTTGTGGCAGAAATGATTGAAAAA
TTTGGAAGATTTACCAAGGAGGAAAAATCAAAAGAGCTAGGTGACGTGATGGTTGACATTGCAAGTAACATCATGTTGGCTGATGAACGT
GTCCTGTGGCTGGCGCAGAGGGAAGCTAAAGCCTGCAGTAGGATTGTGCAGTGTCTTCAGCGCATTGCTACCTACCGGCTAGCCGGTGGA
GCTCACGTTTATTCAACACTTGTTGCAGATCCTTGTGCCAGCAACCCTTGTCACCATGGCAACTGCAGCAGCAGCAGCAGCAGCAGCAGC
GATGGCTACCTCTGCATTTGCAATGAAGGCTATGAAGGTCCCAACTGTGAACAGGCACTTCCCAGTCTCCCAGCCACTGGCTGGACCGAA
TCCATGGCACCCCGACAGCTTCAGCCTGTTCCTGCTACTCAGGAGCCTGACAAAATCCTGCCTCGCTCTCAGGCAACGGTGACACTGCCT
ACCTGGCAGCCGAAAACAGGGCAGAAAGTTGTAGAAATGAAATGGGATCAAGTGGAGGTGATCCCAGATATTGCCTGTGGGAATGCCAGT
TCTAACAGCTCTGCGGGTGGCCGCCTGGTATCCTTTGAAGTGCCACAGAACACCTCAGTCAAGATTCGGCAAGATGCCACTGCCTCACTG
ATTTTGCTCTGGAAGGTCACGGCCACAGGATTCCAACAGTGCTCCCTCATAGATGGACGAAGTGTGACCCCCCTTCAGGCTTCAGGGGGA
CTGGTCCTCCTGGAGGAGATGCTCGCCTTGGGGAATAATCACTTTATTGGTTTTGTGAATGATTCTGTGACTAAGTCTATTGTGGCTTTG
CGCTTAACTCTGGTGGTGAAGGTCAGCACCTGTGTGCCGGGGGAGAGTCACGCAAATGACTTGGAGTGTTCAGGAAAAGGAAAATGCACC
ACGAAGCCGTCAGAGGCAACTTTTTCCTGTACCTGTGAGGAGCAGTACGTGGGTACTTTCTGTGAAGAATACGATGCTTGCCAGAGGAAA
CCTTGCCAAAACAACGCGAGCTGTATTGATGCAAATGAAAAGCAAGATGGGAGCAATTTCACCTGTGTTTGCCTTCCTGGTTATACTGGA
GAGCTTTGCCAGTCCAAGATTGATTACTGCATCCTAGACCCATGCAGAAATGGAGCAACATGCATTTCCAGTCTCAGTGGATTCACCTGC
CAGTGTCCAGAAGGATACTTCGGATCTGCTTGTGAAGAAAAGGTGGACCCCTGCGCCTCGTCTCCGTGCCAGAACAACGGCACCTGCTAT
GTGGACGGGGTACACTTTACCTGCAACTGCAGCCCGGGCTTCACAGGGCCGACCTGTGCCCAGCTTATTGACTTCTGTGCCCTCAGCCCC
TGTGCTCATGGCACGTGCCGCAGCGTGGGCACCAGCTACAAATGCCTCTGTGATCCAGGTTACCATGGCCTCTACTGTGAGGAGGAATAT
AATGAGTGCCTCTCCGCTCCATGCCTGAATGCAGCCACCTGCAGGGACCTCGTTAATGGCTATGAGTGTGTGTGCCTGGCAGAATACAAA
GGAACACACTGTGAATTGTACAAGGATCCCTGCGCTAACGTCAGCTGTCTGAACGGAGCCACCTGTGACAGCGACGGCCTGAATGGCACG
TGCATCTGTGCACCCGGGTTTACAGGTGAAGAGTGCGACATTGACATAAATGAATGTGACAGTAACCCCTGCCACCATGGTGGGAGCTGC
CTGGACCAGCCCAATGGTTATAACTGCCACTGCCCGCATGGTTGGGTGGGAGCAAACTGTGAGATCCACCTCCAATGGAAGTCCGGGCAC
ATGGCGGAGAGCCTCACCAACATGCCACGGCACTCCCTCTACATCATCATTGGAGCCCTCTGCGTGGCCTTCATCCTTATGCTGATCATC
CTGATCGTGGGGATTTGCCGCATCAGCCGCATTGAATACCAGGGTTCTTCCAGGCCAGCCTATGAGGAGTTCTACAACTGCCGCAGCATC
GACAGCGAGTTCAGCAATGCCATTGCATCCATCCGGCATGCCAGGTTTGGAAAGAAATCCCGGCCTGCAATGTATGATGTGAGCCCCATC
GCCTATGAAGATTACAGTCCTGATGACAAACCCTTGGTCACACTGATTAAAACTAAAGATTTGTAATCTTTTTTTGGATTATTTTTCAAA
AAGATGAGATACTACACTCATTTAAATATTTTTAAGAAAATAAAAAGCTTAAGAAATTTAAAATGCTAGCTGCTCAAGAGTTTTCAGTAG
AATATTTAAGAACTAATTTTCTGCAGCTTTTAGTTTGGAAAAAATATTTTAAAAACAAAATTTGTGAAACCTATAGACGATGTTTTAATG
TACCTTCAGCTCTCTAAACTGTGTGCTTCTACTAGTGTGTGCTCTTTTCACTGTAGACACTATCACGAGACCCAGATTAATTTCTGTGGT
TGTTACAGAATAAGTCTAATCAAGGAGAAGTTTCTGTTTGACGTTTGAGTGCCGGCTTTCTGAGTAGAGTTAGGAAAACCACGTAACGTA
GCATATGATGTATAATAGAGTATACCCGTTACTTAAAAAGAAGTCTGAAATGTTCGTTTTGTGGAAAAGAAACTAGTTAAATTTACTATT
CCTAACCCGAATGAAATTAGCCTTTGCCTTATTCTGTGCATGGGTAAGTAACTTATTTCTGCACTGTTTTGTTGAACTTTGTGGAAACAT
TCTTTCGAGTTTGTTTTTGTCATTTTCGTAACAGTCGTCGAACTAGGCCTCAAAAACATACGTAACGAAAAGGCCTAGCGAGGCAAATTC
TGATTGATTTGAATCTATATTTTTCTTTAAAAAGTCAAGGGTTCTATATTGTGAGTAAATTAAATTTACATTTGAGTTGTTTGTTGCTAA
GAGGTAGTAAATGTAAGAGAGTACTGGTTCCTTCAGTAGTGAGTATTTCTCATAGTGCAGCTTTATTTATCTCCAGGATGTTTTTGTGGC

>34367_34367_2_GPR125-DNER_GPR125_chr4_22425814_ENST00000502482_DNER_chr2_230456604_ENST00000341772_length(amino acids)=1180AA_BP=535
MEPPGRRRGRAQPPLLLPLSLLALLALLGGGGGGGAAALPAGCKHDGRPRGAGRAAGAAEGKVVCSSLELAQVLPPDTLPNRTVTLILSN
NKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLDLTNNRIGCLNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLR
SLEFQTEYLLCDCNILWMHRWVKEKNITVRDTRCVYPKSLQAQPVTGVKQELLTCDPPLELPSFYMTPSHRQVVFEGDSLPFQCMASYID
QDMQVLWYQDGRIVETDESQGIFVEKNMIHNCSLIASALTISNIQAGSTGNWGCHVQTKRGNNTRTVDIVVLESSAQYCPPERVVNNKGD
FRWPRTLAGITAYLQCTRNTHGSGIYPGNPQDERKAWRRCDRGGFWADDDYSRCQYANDVTRVLYMFNQMPLNLTNAVATARQLLAYTVE
AANFSDKMDVIFVAEMIEKFGRFTKEEKSKELGDVMVDIASNIMLADERVLWLAQREAKACSRIVQCLQRIATYRLAGGAHVYSTLVADP
CASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPATQEPDKILPRSQATVTLPTWQPKTGQKVV
EMKWDQVEVIPDIACGNASSNSSAGGRLVSFEVPQNTSVKIRQDATASLILLWKVTATGFQQCSLIDGRSVTPLQASGGLVLLEEMLALG
NNHFIGFVNDSVTKSIVALRLTLVVKVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDA
NEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCS
PGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPC
ANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHLQWKSGHMAESLTNMPRH
SLYIIIGALCVAFILMLIILIVGICRISRIEYQGSSRPAYEEFYNCRSIDSEFSNAIASIRHARFGKKSRPAMYDVSPIAYEDYSPDDKP

--------------------------------------------------------------
>34367_34367_3_GPR125-DNER_GPR125_chr4_22425814_ENST00000508133_DNER_chr2_230456604_ENST00000341772_length(transcript)=3804nt_BP=955nt
ATTTCTGTAATCATCTGATACTCTTAGGATGCCACTGAAGAGGAATAACTCTAAATACCCTCCGCTTGAATTGCCGTCTTTCTACATGAC
TCCATCTCATCGCCAAGTTGTGTTTGAAGGAGACAGCCTTCCTTTCCAGTGCATGGCTTCATATATTGATCAGGACATGCAAGTGTTGTG
GTATCAGGATGGGAGAATAGTTGAAACCGATGAATCGCAAGGTATTTTTGTTGAAAAGAACATGATTCACAACTGCTCCTTGATTGCAAG
TGCCCTAACCATTTCTAATATTCAGGCTGGATCTACTGGAAATTGGGGCTGTCATGTCCAGACCAAACGTGGGAATAATACGAGGACTGT
GGATATTGTGGTATTAGAGAGTTCTGCACAGTACTGTCCTCCAGAGAGGGTGGTAAACAACAAAGGTGACTTCAGATGGCCCAGAACATT
GGCAGGCATTACTGCATATCTGCAGTGTACGCGGAACACCCATGGCAGTGGGATATATCCCGGAAACCCACAGGATGAGAGAAAAGCTTG
GCGCAGATGTGATAGAGGTGGCTTTTGGGCAGATGATGATTATTCTCGCTGTCAGTATGCAAATGATGTCACTAGAGTTCTTTATATGTT
TAATCAGATGCCCCTCAATCTTACCAATGCCGTGGCAACAGCTCGACAGTTACTGGCTTACACTGTGGAAGCAGCCAACTTTTCTGACAA
AATGGATGTTATATTTGTGGCAGAAATGATTGAAAAATTTGGAAGATTTACCAAGGAGGAAAAATCAAAAGAGCTAGGTGACGTGATGGT
TGACATTGCAAGTAACATCATGTTGGCTGATGAACGTGTCCTGTGGCTGGCGCAGAGGGAAGCTAAAGCCTGCAGTAGGATTGTGCAGTG
TCTTCAGCGCATTGCTACCTACCGGCTAGCCGGTGGAGCTCACGTTTATTCAACACTTGTTGCAGATCCTTGTGCCAGCAACCCTTGTCA
CCATGGCAACTGCAGCAGCAGCAGCAGCAGCAGCAGCGATGGCTACCTCTGCATTTGCAATGAAGGCTATGAAGGTCCCAACTGTGAACA
GGCACTTCCCAGTCTCCCAGCCACTGGCTGGACCGAATCCATGGCACCCCGACAGCTTCAGCCTGTTCCTGCTACTCAGGAGCCTGACAA
AATCCTGCCTCGCTCTCAGGCAACGGTGACACTGCCTACCTGGCAGCCGAAAACAGGGCAGAAAGTTGTAGAAATGAAATGGGATCAAGT
GGAGGTGATCCCAGATATTGCCTGTGGGAATGCCAGTTCTAACAGCTCTGCGGGTGGCCGCCTGGTATCCTTTGAAGTGCCACAGAACAC
CTCAGTCAAGATTCGGCAAGATGCCACTGCCTCACTGATTTTGCTCTGGAAGGTCACGGCCACAGGATTCCAACAGTGCTCCCTCATAGA
TGGACGAAGTGTGACCCCCCTTCAGGCTTCAGGGGGACTGGTCCTCCTGGAGGAGATGCTCGCCTTGGGGAATAATCACTTTATTGGTTT
TGTGAATGATTCTGTGACTAAGTCTATTGTGGCTTTGCGCTTAACTCTGGTGGTGAAGGTCAGCACCTGTGTGCCGGGGGAGAGTCACGC
AAATGACTTGGAGTGTTCAGGAAAAGGAAAATGCACCACGAAGCCGTCAGAGGCAACTTTTTCCTGTACCTGTGAGGAGCAGTACGTGGG
TACTTTCTGTGAAGAATACGATGCTTGCCAGAGGAAACCTTGCCAAAACAACGCGAGCTGTATTGATGCAAATGAAAAGCAAGATGGGAG
CAATTTCACCTGTGTTTGCCTTCCTGGTTATACTGGAGAGCTTTGCCAGTCCAAGATTGATTACTGCATCCTAGACCCATGCAGAAATGG
AGCAACATGCATTTCCAGTCTCAGTGGATTCACCTGCCAGTGTCCAGAAGGATACTTCGGATCTGCTTGTGAAGAAAAGGTGGACCCCTG
CGCCTCGTCTCCGTGCCAGAACAACGGCACCTGCTATGTGGACGGGGTACACTTTACCTGCAACTGCAGCCCGGGCTTCACAGGGCCGAC
CTGTGCCCAGCTTATTGACTTCTGTGCCCTCAGCCCCTGTGCTCATGGCACGTGCCGCAGCGTGGGCACCAGCTACAAATGCCTCTGTGA
TCCAGGTTACCATGGCCTCTACTGTGAGGAGGAATATAATGAGTGCCTCTCCGCTCCATGCCTGAATGCAGCCACCTGCAGGGACCTCGT
TAATGGCTATGAGTGTGTGTGCCTGGCAGAATACAAAGGAACACACTGTGAATTGTACAAGGATCCCTGCGCTAACGTCAGCTGTCTGAA
CGGAGCCACCTGTGACAGCGACGGCCTGAATGGCACGTGCATCTGTGCACCCGGGTTTACAGGTGAAGAGTGCGACATTGACATAAATGA
ATGTGACAGTAACCCCTGCCACCATGGTGGGAGCTGCCTGGACCAGCCCAATGGTTATAACTGCCACTGCCCGCATGGTTGGGTGGGAGC
AAACTGTGAGATCCACCTCCAATGGAAGTCCGGGCACATGGCGGAGAGCCTCACCAACATGCCACGGCACTCCCTCTACATCATCATTGG
AGCCCTCTGCGTGGCCTTCATCCTTATGCTGATCATCCTGATCGTGGGGATTTGCCGCATCAGCCGCATTGAATACCAGGGTTCTTCCAG
GCCAGCCTATGAGGAGTTCTACAACTGCCGCAGCATCGACAGCGAGTTCAGCAATGCCATTGCATCCATCCGGCATGCCAGGTTTGGAAA
GAAATCCCGGCCTGCAATGTATGATGTGAGCCCCATCGCCTATGAAGATTACAGTCCTGATGACAAACCCTTGGTCACACTGATTAAAAC
TAAAGATTTGTAATCTTTTTTTGGATTATTTTTCAAAAAGATGAGATACTACACTCATTTAAATATTTTTAAGAAAATAAAAAGCTTAAG
AAATTTAAAATGCTAGCTGCTCAAGAGTTTTCAGTAGAATATTTAAGAACTAATTTTCTGCAGCTTTTAGTTTGGAAAAAATATTTTAAA
AACAAAATTTGTGAAACCTATAGACGATGTTTTAATGTACCTTCAGCTCTCTAAACTGTGTGCTTCTACTAGTGTGTGCTCTTTTCACTG
TAGACACTATCACGAGACCCAGATTAATTTCTGTGGTTGTTACAGAATAAGTCTAATCAAGGAGAAGTTTCTGTTTGACGTTTGAGTGCC
GGCTTTCTGAGTAGAGTTAGGAAAACCACGTAACGTAGCATATGATGTATAATAGAGTATACCCGTTACTTAAAAAGAAGTCTGAAATGT
TCGTTTTGTGGAAAAGAAACTAGTTAAATTTACTATTCCTAACCCGAATGAAATTAGCCTTTGCCTTATTCTGTGCATGGGTAAGTAACT
TATTTCTGCACTGTTTTGTTGAACTTTGTGGAAACATTCTTTCGAGTTTGTTTTTGTCATTTTCGTAACAGTCGTCGAACTAGGCCTCAA
AAACATACGTAACGAAAAGGCCTAGCGAGGCAAATTCTGATTGATTTGAATCTATATTTTTCTTTAAAAAGTCAAGGGTTCTATATTGTG
AGTAAATTAAATTTACATTTGAGTTGTTTGTTGCTAAGAGGTAGTAAATGTAAGAGAGTACTGGTTCCTTCAGTAGTGAGTATTTCTCAT
AGTGCAGCTTTATTTATCTCCAGGATGTTTTTGTGGCTGTATTTGATTGATATGTGCTTCTTCTGATTCTTGCTAATTTCCAACCATATT

>34367_34367_3_GPR125-DNER_GPR125_chr4_22425814_ENST00000508133_DNER_chr2_230456604_ENST00000341772_length(amino acids)=954AA_BP=309
MPLKRNNSKYPPLELPSFYMTPSHRQVVFEGDSLPFQCMASYIDQDMQVLWYQDGRIVETDESQGIFVEKNMIHNCSLIASALTISNIQA
GSTGNWGCHVQTKRGNNTRTVDIVVLESSAQYCPPERVVNNKGDFRWPRTLAGITAYLQCTRNTHGSGIYPGNPQDERKAWRRCDRGGFW
ADDDYSRCQYANDVTRVLYMFNQMPLNLTNAVATARQLLAYTVEAANFSDKMDVIFVAEMIEKFGRFTKEEKSKELGDVMVDIASNIMLA
DERVLWLAQREAKACSRIVQCLQRIATYRLAGGAHVYSTLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATG
WTESMAPRQLQPVPATQEPDKILPRSQATVTLPTWQPKTGQKVVEMKWDQVEVIPDIACGNASSNSSAGGRLVSFEVPQNTSVKIRQDAT
ASLILLWKVTATGFQQCSLIDGRSVTPLQASGGLVLLEEMLALGNNHFIGFVNDSVTKSIVALRLTLVVKVSTCVPGESHANDLECSGKG
KCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSG
FTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCE
EEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHG
GSCLDQPNGYNCHCPHGWVGANCEIHLQWKSGHMAESLTNMPRHSLYIIIGALCVAFILMLIILIVGICRISRIEYQGSSRPAYEEFYNC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GPR125-DNER


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneDNERchr4:22425814chr2:230456604ENST00000341772013677_68092.0738.0AP1G1 and somatodendritic targeting


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneDNERchr4:22425814chr2:230456604ENST0000034177201344_13392.0738.0NOTCH1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GPR125-DNER


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GPR125-DNER


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource