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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GPR125-ERBB2 (FusionGDB2 ID:34368)

Fusion Gene Summary for GPR125-ERBB2

check button Fusion gene summary
Fusion gene informationFusion gene name: GPR125-ERBB2
Fusion gene ID: 34368
HgeneTgene
Gene symbol

GPR125

ERBB2

Gene ID

166647

2064

Gene nameadhesion G protein-coupled receptor A3erb-b2 receptor tyrosine kinase 2
SynonymsGPR125|PGR21|TEM5LCD340|HER-2|HER-2/neu|HER2|MLN 19|NEU|NGL|TKR1
Cytomap

4p15.2

17q12

Type of geneprotein-codingprotein-coding
Descriptionadhesion G protein-coupled receptor A3G-protein coupled receptor 125probable G-protein coupled receptor 125receptor tyrosine-protein kinase erbB-2c-erb B2/neu proteinherstatinhuman epidermal growth factor receptor 2metastatic lymph node gene 19 proteinneuro/glioblastoma derived oncogene homologneuroblastoma/glioblastoma derived oncogene homologp185erbB2
Modification date2020031320200329
UniProtAcc.

P04626

Ensembl transtripts involved in fusion geneENST00000334304, ENST00000502482, 
ENST00000282943, ENST00000508133, 
ENST00000406381, ENST00000578199, 
ENST00000584601, ENST00000269571, 
ENST00000445658, ENST00000540042, 
ENST00000540147, ENST00000541774, 
ENST00000584450, ENST00000584888, 
Fusion gene scores* DoF score2 X 2 X 2=834 X 40 X 10=13600
# samples 243
** MAII scorelog2(2/8*10)=1.32192809488736log2(43/13600*10)=-4.9831261814356
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GPR125 [Title/Abstract] AND ERBB2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGPR125(22475395)-ERBB2(37849514), # samples:1
GPR125(22475395)-ERBB2(37844949), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneERBB2

GO:0007165

signal transduction

10572067

TgeneERBB2

GO:0007166

cell surface receptor signaling pathway

9685399

TgeneERBB2

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

7514177

TgeneERBB2

GO:0014065

phosphatidylinositol 3-kinase signaling

7556068

TgeneERBB2

GO:0018108

peptidyl-tyrosine phosphorylation

12000754

TgeneERBB2

GO:0032886

regulation of microtubule-based process

20937854

TgeneERBB2

GO:0035556

intracellular signal transduction

19372587

TgeneERBB2

GO:0042060

wound healing

12646923

TgeneERBB2

GO:0043406

positive regulation of MAP kinase activity

10572067

TgeneERBB2

GO:0045785

positive regulation of cell adhesion

7556068

TgeneERBB2

GO:0046777

protein autophosphorylation

7556068

TgeneERBB2

GO:0050679

positive regulation of epithelial cell proliferation

10572067

TgeneERBB2

GO:0071363

cellular response to growth factor stimulus

20010870

TgeneERBB2

GO:0090314

positive regulation of protein targeting to membrane

20010870


check buttonFusion gene breakpoints across GPR125 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ERBB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A1X5-01AGPR125chr4

22475395

-ERBB2chr17

37844949

+
ChimerDB4BRCATCGA-D8-A1X5-01AGPR125chr4

22475395

-ERBB2chr17

37849514

+


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Fusion Gene ORF analysis for GPR125-ERBB2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000334304ENST00000406381GPR125chr4

22475395

-ERBB2chr17

37844949

+
5CDS-5UTRENST00000334304ENST00000578199GPR125chr4

22475395

-ERBB2chr17

37844949

+
5CDS-5UTRENST00000334304ENST00000578199GPR125chr4

22475395

-ERBB2chr17

37849514

+
5CDS-5UTRENST00000334304ENST00000584601GPR125chr4

22475395

-ERBB2chr17

37844949

+
5CDS-5UTRENST00000334304ENST00000584601GPR125chr4

22475395

-ERBB2chr17

37849514

+
5CDS-5UTRENST00000502482ENST00000406381GPR125chr4

22475395

-ERBB2chr17

37844949

+
5CDS-5UTRENST00000502482ENST00000578199GPR125chr4

22475395

-ERBB2chr17

37844949

+
5CDS-5UTRENST00000502482ENST00000578199GPR125chr4

22475395

-ERBB2chr17

37849514

+
5CDS-5UTRENST00000502482ENST00000584601GPR125chr4

22475395

-ERBB2chr17

37844949

+
5CDS-5UTRENST00000502482ENST00000584601GPR125chr4

22475395

-ERBB2chr17

37849514

+
5CDS-intronENST00000334304ENST00000269571GPR125chr4

22475395

-ERBB2chr17

37844949

+
5CDS-intronENST00000334304ENST00000269571GPR125chr4

22475395

-ERBB2chr17

37849514

+
5CDS-intronENST00000334304ENST00000406381GPR125chr4

22475395

-ERBB2chr17

37849514

+
5CDS-intronENST00000334304ENST00000445658GPR125chr4

22475395

-ERBB2chr17

37844949

+
5CDS-intronENST00000334304ENST00000445658GPR125chr4

22475395

-ERBB2chr17

37849514

+
5CDS-intronENST00000334304ENST00000540042GPR125chr4

22475395

-ERBB2chr17

37844949

+
5CDS-intronENST00000334304ENST00000540042GPR125chr4

22475395

-ERBB2chr17

37849514

+
5CDS-intronENST00000334304ENST00000540147GPR125chr4

22475395

-ERBB2chr17

37844949

+
5CDS-intronENST00000334304ENST00000540147GPR125chr4

22475395

-ERBB2chr17

37849514

+
5CDS-intronENST00000334304ENST00000541774GPR125chr4

22475395

-ERBB2chr17

37844949

+
5CDS-intronENST00000334304ENST00000541774GPR125chr4

22475395

-ERBB2chr17

37849514

+
5CDS-intronENST00000334304ENST00000584450GPR125chr4

22475395

-ERBB2chr17

37844949

+
5CDS-intronENST00000334304ENST00000584450GPR125chr4

22475395

-ERBB2chr17

37849514

+
5CDS-intronENST00000334304ENST00000584888GPR125chr4

22475395

-ERBB2chr17

37844949

+
5CDS-intronENST00000334304ENST00000584888GPR125chr4

22475395

-ERBB2chr17

37849514

+
5CDS-intronENST00000502482ENST00000269571GPR125chr4

22475395

-ERBB2chr17

37844949

+
5CDS-intronENST00000502482ENST00000269571GPR125chr4

22475395

-ERBB2chr17

37849514

+
5CDS-intronENST00000502482ENST00000406381GPR125chr4

22475395

-ERBB2chr17

37849514

+
5CDS-intronENST00000502482ENST00000445658GPR125chr4

22475395

-ERBB2chr17

37844949

+
5CDS-intronENST00000502482ENST00000445658GPR125chr4

22475395

-ERBB2chr17

37849514

+
5CDS-intronENST00000502482ENST00000540042GPR125chr4

22475395

-ERBB2chr17

37844949

+
5CDS-intronENST00000502482ENST00000540042GPR125chr4

22475395

-ERBB2chr17

37849514

+
5CDS-intronENST00000502482ENST00000540147GPR125chr4

22475395

-ERBB2chr17

37844949

+
5CDS-intronENST00000502482ENST00000540147GPR125chr4

22475395

-ERBB2chr17

37849514

+
5CDS-intronENST00000502482ENST00000541774GPR125chr4

22475395

-ERBB2chr17

37844949

+
5CDS-intronENST00000502482ENST00000541774GPR125chr4

22475395

-ERBB2chr17

37849514

+
5CDS-intronENST00000502482ENST00000584450GPR125chr4

22475395

-ERBB2chr17

37844949

+
5CDS-intronENST00000502482ENST00000584450GPR125chr4

22475395

-ERBB2chr17

37849514

+
5CDS-intronENST00000502482ENST00000584888GPR125chr4

22475395

-ERBB2chr17

37844949

+
5CDS-intronENST00000502482ENST00000584888GPR125chr4

22475395

-ERBB2chr17

37849514

+
intron-5UTRENST00000282943ENST00000406381GPR125chr4

22475395

-ERBB2chr17

37844949

+
intron-5UTRENST00000282943ENST00000578199GPR125chr4

22475395

-ERBB2chr17

37844949

+
intron-5UTRENST00000282943ENST00000578199GPR125chr4

22475395

-ERBB2chr17

37849514

+
intron-5UTRENST00000282943ENST00000584601GPR125chr4

22475395

-ERBB2chr17

37844949

+
intron-5UTRENST00000282943ENST00000584601GPR125chr4

22475395

-ERBB2chr17

37849514

+
intron-5UTRENST00000508133ENST00000406381GPR125chr4

22475395

-ERBB2chr17

37844949

+
intron-5UTRENST00000508133ENST00000578199GPR125chr4

22475395

-ERBB2chr17

37844949

+
intron-5UTRENST00000508133ENST00000578199GPR125chr4

22475395

-ERBB2chr17

37849514

+
intron-5UTRENST00000508133ENST00000584601GPR125chr4

22475395

-ERBB2chr17

37844949

+
intron-5UTRENST00000508133ENST00000584601GPR125chr4

22475395

-ERBB2chr17

37849514

+
intron-intronENST00000282943ENST00000269571GPR125chr4

22475395

-ERBB2chr17

37844949

+
intron-intronENST00000282943ENST00000269571GPR125chr4

22475395

-ERBB2chr17

37849514

+
intron-intronENST00000282943ENST00000406381GPR125chr4

22475395

-ERBB2chr17

37849514

+
intron-intronENST00000282943ENST00000445658GPR125chr4

22475395

-ERBB2chr17

37844949

+
intron-intronENST00000282943ENST00000445658GPR125chr4

22475395

-ERBB2chr17

37849514

+
intron-intronENST00000282943ENST00000540042GPR125chr4

22475395

-ERBB2chr17

37844949

+
intron-intronENST00000282943ENST00000540042GPR125chr4

22475395

-ERBB2chr17

37849514

+
intron-intronENST00000282943ENST00000540147GPR125chr4

22475395

-ERBB2chr17

37844949

+
intron-intronENST00000282943ENST00000540147GPR125chr4

22475395

-ERBB2chr17

37849514

+
intron-intronENST00000282943ENST00000541774GPR125chr4

22475395

-ERBB2chr17

37844949

+
intron-intronENST00000282943ENST00000541774GPR125chr4

22475395

-ERBB2chr17

37849514

+
intron-intronENST00000282943ENST00000584450GPR125chr4

22475395

-ERBB2chr17

37844949

+
intron-intronENST00000282943ENST00000584450GPR125chr4

22475395

-ERBB2chr17

37849514

+
intron-intronENST00000282943ENST00000584888GPR125chr4

22475395

-ERBB2chr17

37844949

+
intron-intronENST00000282943ENST00000584888GPR125chr4

22475395

-ERBB2chr17

37849514

+
intron-intronENST00000508133ENST00000269571GPR125chr4

22475395

-ERBB2chr17

37844949

+
intron-intronENST00000508133ENST00000269571GPR125chr4

22475395

-ERBB2chr17

37849514

+
intron-intronENST00000508133ENST00000406381GPR125chr4

22475395

-ERBB2chr17

37849514

+
intron-intronENST00000508133ENST00000445658GPR125chr4

22475395

-ERBB2chr17

37844949

+
intron-intronENST00000508133ENST00000445658GPR125chr4

22475395

-ERBB2chr17

37849514

+
intron-intronENST00000508133ENST00000540042GPR125chr4

22475395

-ERBB2chr17

37844949

+
intron-intronENST00000508133ENST00000540042GPR125chr4

22475395

-ERBB2chr17

37849514

+
intron-intronENST00000508133ENST00000540147GPR125chr4

22475395

-ERBB2chr17

37844949

+
intron-intronENST00000508133ENST00000540147GPR125chr4

22475395

-ERBB2chr17

37849514

+
intron-intronENST00000508133ENST00000541774GPR125chr4

22475395

-ERBB2chr17

37844949

+
intron-intronENST00000508133ENST00000541774GPR125chr4

22475395

-ERBB2chr17

37849514

+
intron-intronENST00000508133ENST00000584450GPR125chr4

22475395

-ERBB2chr17

37844949

+
intron-intronENST00000508133ENST00000584450GPR125chr4

22475395

-ERBB2chr17

37849514

+
intron-intronENST00000508133ENST00000584888GPR125chr4

22475395

-ERBB2chr17

37844949

+
intron-intronENST00000508133ENST00000584888GPR125chr4

22475395

-ERBB2chr17

37849514

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for GPR125-ERBB2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GPR125chr422475394-ERBB2chr1737844948+0.0143444640.98565555
GPR125chr422475394-ERBB2chr1737849513+3.86E-060.9999962
GPR125chr422475394-ERBB2chr1737844948+0.0143444640.98565555
GPR125chr422475394-ERBB2chr1737849513+3.86E-060.9999962

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GPR125-ERBB2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:22475395/:37849514)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ERBB2

P04626

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269|PubMed:10358079, ECO:0000269|PubMed:15380516, ECO:0000269|PubMed:21555369}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for GPR125-ERBB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GPR125-ERBB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GPR125-ERBB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GPR125-ERBB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource