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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GPR128-LNP1 (FusionGDB2 ID:34372)

Fusion Gene Summary for GPR128-LNP1

check button Fusion gene summary
Fusion gene informationFusion gene name: GPR128-LNP1
Fusion gene ID: 34372
HgeneTgene
Gene symbol

GPR128

LNP1

Gene ID

84873

348801

Gene nameadhesion G protein-coupled receptor G7leukemia NUP98 fusion partner 1
SynonymsGPR128NP3
Cytomap

3q12.2

3q12.2

Type of geneprotein-codingprotein-coding
Descriptionadhesion G-protein coupled receptor G7G-protein coupled receptor 128leukemia NUP98 fusion partner 1
Modification date2020031320200313
UniProtAcc.

A1A4G5

Ensembl transtripts involved in fusion geneENST00000481506, ENST00000273352, 
ENST00000475887, 		ENST00000383693, 
ENST00000489752, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 3 X 4=60
# samples 18
** MAII scorelog2(1/1*10)=3.32192809488736log2(8/60*10)=0.415037499278844
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GPR128 [Title/Abstract] AND LNP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGPR128(100387949)-LNP1(100170563), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across GPR128 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LNP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-7716-01AGPR128chr3

100387949

+LNP1chr3

100170563

+


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Fusion Gene ORF analysis for GPR128-LNP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000481506ENST00000383693GPR128chr3

100387949

+LNP1chr3

100170563

+
3UTR-3CDSENST00000481506ENST00000489752GPR128chr3

100387949

+LNP1chr3

100170563

+
In-frameENST00000273352ENST00000383693GPR128chr3

100387949

+LNP1chr3

100170563

+
In-frameENST00000273352ENST00000489752GPR128chr3

100387949

+LNP1chr3

100170563

+
In-frameENST00000475887ENST00000383693GPR128chr3

100387949

+LNP1chr3

100170563

+
In-frameENST00000475887ENST00000489752GPR128chr3

100387949

+LNP1chr3

100170563

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000273352GPR128chr3100387949+ENST00000383693LNP1chr3100170563+317824042502784844
ENST00000273352GPR128chr3100387949+ENST00000489752LNP1chr3100170563+315924042502676808
ENST00000475887GPR128chr3100387949+ENST00000383693LNP1chr3100170563+229415202691900543
ENST00000475887GPR128chr3100387949+ENST00000489752LNP1chr3100170563+227515202691792507

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000273352ENST00000383693GPR128chr3100387949+LNP1chr3100170563+0.0004812660.99951875
ENST00000273352ENST00000489752GPR128chr3100387949+LNP1chr3100170563+0.000525110.99947494
ENST00000475887ENST00000383693GPR128chr3100387949+LNP1chr3100170563+0.0007306010.9992694
ENST00000475887ENST00000489752GPR128chr3100387949+LNP1chr3100170563+0.0006807580.9993193

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Fusion Genomic Features for GPR128-LNP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GPR128chr3100387949+LNP1chr3100170562+3.07E-070.99999964
GPR128chr3100387949+LNP1chr3100170562+3.07E-070.99999964

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GPR128-LNP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:100387949/chr3:100170563)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LNP1

A1A4G5

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGPR128chr3:100387949chr3:100170563ENST00000273352+1516380_427712798.0DomainGPS
HgeneGPR128chr3:100387949chr3:100170563ENST00000273352+151627_438712798.0Topological domainExtracellular
HgeneGPR128chr3:100387949chr3:100170563ENST00000273352+1516460_468712798.0Topological domainCytoplasmic
HgeneGPR128chr3:100387949chr3:100170563ENST00000273352+1516490_528712798.0Topological domainExtracellular
HgeneGPR128chr3:100387949chr3:100170563ENST00000273352+1516550_565712798.0Topological domainCytoplasmic
HgeneGPR128chr3:100387949chr3:100170563ENST00000273352+1516587_623712798.0Topological domainExtracellular
HgeneGPR128chr3:100387949chr3:100170563ENST00000273352+1516645_669712798.0Topological domainCytoplasmic
HgeneGPR128chr3:100387949chr3:100170563ENST00000273352+1516691_698712798.0Topological domainExtracellular
HgeneGPR128chr3:100387949chr3:100170563ENST00000273352+1516439_459712798.0TransmembraneHelical%3B Name%3D1
HgeneGPR128chr3:100387949chr3:100170563ENST00000273352+1516469_489712798.0TransmembraneHelical%3B Name%3D2
HgeneGPR128chr3:100387949chr3:100170563ENST00000273352+1516529_549712798.0TransmembraneHelical%3B Name%3D3
HgeneGPR128chr3:100387949chr3:100170563ENST00000273352+1516566_586712798.0TransmembraneHelical%3B Name%3D4
HgeneGPR128chr3:100387949chr3:100170563ENST00000273352+1516624_644712798.0TransmembraneHelical%3B Name%3D5
HgeneGPR128chr3:100387949chr3:100170563ENST00000273352+1516670_690712798.0TransmembraneHelical%3B Name%3D6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGPR128chr3:100387949chr3:100170563ENST00000273352+1516720_797712798.0Topological domainCytoplasmic
HgeneGPR128chr3:100387949chr3:100170563ENST00000273352+1516699_719712798.0TransmembraneHelical%3B Name%3D7
TgeneLNP1chr3:100387949chr3:100170563ENST00000383693145_1052179.0Compositional biasNote=Poly-Asp


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Fusion Gene Sequence for GPR128-LNP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>34372_34372_1_GPR128-LNP1_GPR128_chr3_100387949_ENST00000273352_LNP1_chr3_100170563_ENST00000383693_length(transcript)=3178nt_BP=2404nt
ATAACTCTAATCACTTTTTTCATGTTCTCCTTGAGTGAAGGATGAGGAAATTGAAAGCAGAGTATGCACCTTTTATTAGGAGATTCAAAC
TGCATCCTACTGGATTAGCCTCAAAAGTCCTAAAATACAAAGACATCCATCTGACAGATCACTGAGGGGAGGACTTGTTTTTCTGTTTTA
GAATAGTTTCCGATTAAACTTTTTAGCTCAAGAAGAAAAGAAGCTAGTTATTTCTCACCCAGGAGTGGATTTGTGGTTTGGCTTCACCAT
GGCTTCCTGCCGTGCCTGGAACCTTAGGGTGCTGGTGGCTGTCGTGTGTGGACTACTGACTGGCATCATTTTGGGACTGGGCATCTGGAG
GATTGTGATCAGGATCCAAAGAGGAAAATCTACTTCCTCATCAAGCACCCCTACAGAGTTCTGCAGGAATGGTGGAACCTGGGAAAATGG
CAGATGTATTTGTACAGAAGAGTGGAAAGGACTGAGATGTACAATTGCTAATTTTTGTGAAAATAGTACCTATATGGGTTTTACTTTTGC
CAGAATCCCAGTGGGCAGATATGGACCATCCTTGCAAACATGTGGCAAGGATACTCCAAATGCGGGCAATCCAATGGCAGTCCGGTTGTG
CAGTCTCTCTCTATATGGAGAGATAGAATTACAAAAAGTGACAATAGGAAATTGCAATGAAAATCTGGAAACCCTGGAAAAGCAGGTAAA
GGATGTCACAGCACCACTTAATAACATTTCTTCTGAAGTCCAGATTTTAACATCTGATGCCAATAAATTAACTGCTGAGAACATCACTAG
TGCTACGCGAGTGGTTGGACAGATATTCAACACTTCCAGAAATGCTTCACCTGAGGCAAAGAAAGTTGCCATAGTAACAGTGAGTCAACT
CCTAGATGCCAGTGAAGATGCTTTTCAAAGAGTTGCTGCTACTGCTAATGATGATGCCCTTACAACGCTTATTGAGCAAATGGAGACTTA
TTCCTTGTCTTTGGGTAATCAATCAGTGGTGGAACCTAACATAGCAATACAGTCAGCAAATTTCTCTTCAGAAAATGCGGTGGGGCCTTC
AAATGTTCGCTTCTCTGTGCAGAAAGGAGCTAGCAGTTCTCTAGTTTCTAGTTCAACATTTATACATACAAATGTGGATGGCCTTAACCC
AGATGCACAGACTGAGCTTCAGGTCTTGCTTAATATGACGAAAAATTACACCAAGACATGCGGCTTTGTAGTTTATCAAAATGACAAGCT
TTTCCAATCAAAAACTTTTACAGCTAAATCGGATTTTAGTCAAAAAATTATCTCAAGCAAAACTGATGAAAATGAGCAAGATCAGAGTGC
TTCTGTTGACATGGTCTTTAGTCCAAAGTACAACCAAAAAGAATTTCAACTCTATTCCTATGCCTGTGTCTATTGGAATTTGTCAGCGAA
GGACTGGGACACATATGGCTGTCAAAAAGACAAGGGCACTGATGGATTCCTGCGCTGCCGCTGCAACCATACTACTAATTTTGCTGTATT
AATGACTTTCAAAAAGGATTATCAATATCCCAAATCACTTGACATATTATCCAACGTTGGATGTGCACTGTCTGTTACTGGTCTGGCTCT
CACAGTTATATTTCAGATTGTCACCAGGAAAGTCAGAAAAACCTCAGTAACCTGGGTTTTGGTCAATCTGTGCATATCAATGTTGATTTT
CAACCTCCTCTTTGTGTTTGGAATTGAAAACTCCAATAAGAACTTGCAGACAAGTGATGGTGACATCAATAATATTGACTTTGACAATAA
TGACATACCCAGGACAGACACCATTAACATCCCGAATCCCATGTGCACTGCGATTGCCGCCTTACTGCACTATTTTCTGTTAGTGACATT
TACCTGGAACGCACTCAGCGCTGCACAGCTCTATTACCTTCTAATAAGGACCATGAAGCCTCTTCCTCGGCATTTCATTCTTTTCATCTC
ATTAATTGGATGGGGAGTCCCAGCTATAGTAGTGGCTATAACAGTGGGAGTTATTTATTCTCAGAATGGAAATAATCCACAGTGGGAATT
AGACTACCGGCAAGAGAAAATCTGCTGGCTGGCAATTCCAGAACCCAATGGTGTTATAAAAAGTCCGCTGTTGTGGTCATTCATCGTACC
TGTAACCATTATCCTCATCAGCAATGTTGTTATGTTTATTACAATCTCGATCAAAGTGCTGTGGAAGAATAACCAGAACCTGACAAGCAC
AAAAAAAGTTTCATCCATGAAGAAGATTGTTAGCACATTATCTGTTGCAGTTGTTTTTGGAATTACCTGGATTCTAGCATACCTGATGCT
AGTTAATGATGATAGCATCAGGATCGTCTTCAGCTACATATTCTGCCTTTTCAACACTACACAGCTTCCTGTGCTTCCCAGAATTCCATC
ATCTGACTGCCATCCTAGAAGGCATTCTCATGAGGACCAAGAATTTCGATGCCGTAGCCACGTACGGGATTACAGAAAATACTCAGAGGA
TGGGTCATTCAAGGAGCCACTGGAATCAAAAGGAAGATCCCATTCCAAAATTGAGAAATTTTCAGAGTCCTTTGAACGGCAACTGTGCTT
TAGAACCAAGCGTTCTGCCTCTTTGGGACCTGAAAGCAGAAAGGAGAGAAATGAAAGAGAATGCCTGAGGATGGAGATAAAATCCCGAAA
GAAAGTAGAGGAAGAAAGGAGCTCTAGGAAAGAAGAGCATGGAGAAGCACACATGGCTCCCCTGTTTGAAAAAGGGCCTGAATAATACTC
TGCTTCTGCCTCATGACATCAGATGCTACTGTTTTGGTTTTTTTCTTTGAGCCCCAATTCACCATTTCAGGATGTGGATGGGGGCGGGGT
TGGGGGTAAAAACAGCTATAAAAAGCAACTGCAGATGCTGACTGACTGCAGTGGGCAGGGTATGTAGCTGCTCCAAGATGACTTGCATCA
TACCCCAATTACTGCTGGCATCTTAGTTGAGAGTATAATCTGCTTGGTTGCCTTTTTATGGGAATAAAGAGAATAAAAGGTATTTTAATA
GAATAAAGAAAAATTTGAAAATATAATGGAAGGTATTTAAAGAGCCACCCACATAGCTTCACCAACCCTTCTCACACATCAACTCATAAA

>34372_34372_1_GPR128-LNP1_GPR128_chr3_100387949_ENST00000273352_LNP1_chr3_100170563_ENST00000383693_length(amino acids)=844AA_BP=717
MWFGFTMASCRAWNLRVLVAVVCGLLTGIILGLGIWRIVIRIQRGKSTSSSSTPTEFCRNGGTWENGRCICTEEWKGLRCTIANFCENST
YMGFTFARIPVGRYGPSLQTCGKDTPNAGNPMAVRLCSLSLYGEIELQKVTIGNCNENLETLEKQVKDVTAPLNNISSEVQILTSDANKL
TAENITSATRVVGQIFNTSRNASPEAKKVAIVTVSQLLDASEDAFQRVAATANDDALTTLIEQMETYSLSLGNQSVVEPNIAIQSANFSS
ENAVGPSNVRFSVQKGASSSLVSSSTFIHTNVDGLNPDAQTELQVLLNMTKNYTKTCGFVVYQNDKLFQSKTFTAKSDFSQKIISSKTDE
NEQDQSASVDMVFSPKYNQKEFQLYSYACVYWNLSAKDWDTYGCQKDKGTDGFLRCRCNHTTNFAVLMTFKKDYQYPKSLDILSNVGCAL
SVTGLALTVIFQIVTRKVRKTSVTWVLVNLCISMLIFNLLFVFGIENSNKNLQTSDGDINNIDFDNNDIPRTDTINIPNPMCTAIAALLH
YFLLVTFTWNALSAAQLYYLLIRTMKPLPRHFILFISLIGWGVPAIVVAITVGVIYSQNGNNPQWELDYRQEKICWLAIPEPNGVIKSPL
LWSFIVPVTIILISNVVMFITISIKVLWKNNQNLTSTKKVSSMKKIVSTLSVAVVFGITWILAYLMLVNDDSIRIVFSYIFCLFNTTQLP
VLPRIPSSDCHPRRHSHEDQEFRCRSHVRDYRKYSEDGSFKEPLESKGRSHSKIEKFSESFERQLCFRTKRSASLGPESRKERNERECLR

--------------------------------------------------------------
>34372_34372_2_GPR128-LNP1_GPR128_chr3_100387949_ENST00000273352_LNP1_chr3_100170563_ENST00000489752_length(transcript)=3159nt_BP=2404nt
ATAACTCTAATCACTTTTTTCATGTTCTCCTTGAGTGAAGGATGAGGAAATTGAAAGCAGAGTATGCACCTTTTATTAGGAGATTCAAAC
TGCATCCTACTGGATTAGCCTCAAAAGTCCTAAAATACAAAGACATCCATCTGACAGATCACTGAGGGGAGGACTTGTTTTTCTGTTTTA
GAATAGTTTCCGATTAAACTTTTTAGCTCAAGAAGAAAAGAAGCTAGTTATTTCTCACCCAGGAGTGGATTTGTGGTTTGGCTTCACCAT
GGCTTCCTGCCGTGCCTGGAACCTTAGGGTGCTGGTGGCTGTCGTGTGTGGACTACTGACTGGCATCATTTTGGGACTGGGCATCTGGAG
GATTGTGATCAGGATCCAAAGAGGAAAATCTACTTCCTCATCAAGCACCCCTACAGAGTTCTGCAGGAATGGTGGAACCTGGGAAAATGG
CAGATGTATTTGTACAGAAGAGTGGAAAGGACTGAGATGTACAATTGCTAATTTTTGTGAAAATAGTACCTATATGGGTTTTACTTTTGC
CAGAATCCCAGTGGGCAGATATGGACCATCCTTGCAAACATGTGGCAAGGATACTCCAAATGCGGGCAATCCAATGGCAGTCCGGTTGTG
CAGTCTCTCTCTATATGGAGAGATAGAATTACAAAAAGTGACAATAGGAAATTGCAATGAAAATCTGGAAACCCTGGAAAAGCAGGTAAA
GGATGTCACAGCACCACTTAATAACATTTCTTCTGAAGTCCAGATTTTAACATCTGATGCCAATAAATTAACTGCTGAGAACATCACTAG
TGCTACGCGAGTGGTTGGACAGATATTCAACACTTCCAGAAATGCTTCACCTGAGGCAAAGAAAGTTGCCATAGTAACAGTGAGTCAACT
CCTAGATGCCAGTGAAGATGCTTTTCAAAGAGTTGCTGCTACTGCTAATGATGATGCCCTTACAACGCTTATTGAGCAAATGGAGACTTA
TTCCTTGTCTTTGGGTAATCAATCAGTGGTGGAACCTAACATAGCAATACAGTCAGCAAATTTCTCTTCAGAAAATGCGGTGGGGCCTTC
AAATGTTCGCTTCTCTGTGCAGAAAGGAGCTAGCAGTTCTCTAGTTTCTAGTTCAACATTTATACATACAAATGTGGATGGCCTTAACCC
AGATGCACAGACTGAGCTTCAGGTCTTGCTTAATATGACGAAAAATTACACCAAGACATGCGGCTTTGTAGTTTATCAAAATGACAAGCT
TTTCCAATCAAAAACTTTTACAGCTAAATCGGATTTTAGTCAAAAAATTATCTCAAGCAAAACTGATGAAAATGAGCAAGATCAGAGTGC
TTCTGTTGACATGGTCTTTAGTCCAAAGTACAACCAAAAAGAATTTCAACTCTATTCCTATGCCTGTGTCTATTGGAATTTGTCAGCGAA
GGACTGGGACACATATGGCTGTCAAAAAGACAAGGGCACTGATGGATTCCTGCGCTGCCGCTGCAACCATACTACTAATTTTGCTGTATT
AATGACTTTCAAAAAGGATTATCAATATCCCAAATCACTTGACATATTATCCAACGTTGGATGTGCACTGTCTGTTACTGGTCTGGCTCT
CACAGTTATATTTCAGATTGTCACCAGGAAAGTCAGAAAAACCTCAGTAACCTGGGTTTTGGTCAATCTGTGCATATCAATGTTGATTTT
CAACCTCCTCTTTGTGTTTGGAATTGAAAACTCCAATAAGAACTTGCAGACAAGTGATGGTGACATCAATAATATTGACTTTGACAATAA
TGACATACCCAGGACAGACACCATTAACATCCCGAATCCCATGTGCACTGCGATTGCCGCCTTACTGCACTATTTTCTGTTAGTGACATT
TACCTGGAACGCACTCAGCGCTGCACAGCTCTATTACCTTCTAATAAGGACCATGAAGCCTCTTCCTCGGCATTTCATTCTTTTCATCTC
ATTAATTGGATGGGGAGTCCCAGCTATAGTAGTGGCTATAACAGTGGGAGTTATTTATTCTCAGAATGGAAATAATCCACAGTGGGAATT
AGACTACCGGCAAGAGAAAATCTGCTGGCTGGCAATTCCAGAACCCAATGGTGTTATAAAAAGTCCGCTGTTGTGGTCATTCATCGTACC
TGTAACCATTATCCTCATCAGCAATGTTGTTATGTTTATTACAATCTCGATCAAAGTGCTGTGGAAGAATAACCAGAACCTGACAAGCAC
AAAAAAAGTTTCATCCATGAAGAAGATTGTTAGCACATTATCTGTTGCAGTTGTTTTTGGAATTACCTGGATTCTAGCATACCTGATGCT
AGTTAATGATGATAGCATCAGGATCGTCTTCAGCTACATATTCTGCCTTTTCAACACTACACAGTTCCTGTGCTTCCCAGAATTCCATCA
TCTGACTGCCATCCTAGAAGGCATTCTCATGAGGACCAAGAATTTCGATGCCGTAGCCACGTACGGGATTACAGAAAATACTCAGAGGAT
GGGTCATTCAAGGAGCCACTGGAATCAAAAGGAAGATCCCATTCCAAAATTGAGAAATTTTCAGAGTCCTTTGAACGGCAACTGTGCTTT
AGAACCAAGCGTTCTGCCTCTTTGGGACCTGAAAGCAGAAAGGAGAGAAATGAAAGAGAATGCCTGAGGATGGAGATAAAATCCCGAAAG
AAAGTAGAGGAAGAAAGGAGCTCTAGGAAAGAAGAGCATGGAGAAGCACACATGGCTCCCCTGTTTGAAAAAGGGCCTGAATAATACTCT
GCTTCTGCCTCATGACATCAGATGCTACTGTTTTGGTTTTTTTCTTTGAGCCCCAATTCACCATTTCAGGATGTGGATGGGGGCGGGGTT
GGGGGTAAAAACAGCTATAAAAAGCAACTGCAGATGCTGACTGACTGCAGTGGGCAGGGTATGTAGCTGCTCCAAGATGACTTGCATCAT
ACCCCAATTACTGCTGGCATCTTAGTTGAGAGTATAATCTGCTTGGTTGCCTTTTTATGGGAATAAAGAGAATAAAAGGTATTTTAATAG
AATAAAGAAAAATTTGAAAATATAATGGAAGGTATTTAAAGAGCCACCCACATAGCTTCACCAACCCTTCTCACACATCAACTCATAAAT

>34372_34372_2_GPR128-LNP1_GPR128_chr3_100387949_ENST00000273352_LNP1_chr3_100170563_ENST00000489752_length(amino acids)=808AA_BP=718
MWFGFTMASCRAWNLRVLVAVVCGLLTGIILGLGIWRIVIRIQRGKSTSSSSTPTEFCRNGGTWENGRCICTEEWKGLRCTIANFCENST
YMGFTFARIPVGRYGPSLQTCGKDTPNAGNPMAVRLCSLSLYGEIELQKVTIGNCNENLETLEKQVKDVTAPLNNISSEVQILTSDANKL
TAENITSATRVVGQIFNTSRNASPEAKKVAIVTVSQLLDASEDAFQRVAATANDDALTTLIEQMETYSLSLGNQSVVEPNIAIQSANFSS
ENAVGPSNVRFSVQKGASSSLVSSSTFIHTNVDGLNPDAQTELQVLLNMTKNYTKTCGFVVYQNDKLFQSKTFTAKSDFSQKIISSKTDE
NEQDQSASVDMVFSPKYNQKEFQLYSYACVYWNLSAKDWDTYGCQKDKGTDGFLRCRCNHTTNFAVLMTFKKDYQYPKSLDILSNVGCAL
SVTGLALTVIFQIVTRKVRKTSVTWVLVNLCISMLIFNLLFVFGIENSNKNLQTSDGDINNIDFDNNDIPRTDTINIPNPMCTAIAALLH
YFLLVTFTWNALSAAQLYYLLIRTMKPLPRHFILFISLIGWGVPAIVVAITVGVIYSQNGNNPQWELDYRQEKICWLAIPEPNGVIKSPL
LWSFIVPVTIILISNVVMFITISIKVLWKNNQNLTSTKKVSSMKKIVSTLSVAVVFGITWILAYLMLVNDDSIRIVFSYIFCLFNTTQFL

--------------------------------------------------------------
>34372_34372_3_GPR128-LNP1_GPR128_chr3_100387949_ENST00000475887_LNP1_chr3_100170563_ENST00000383693_length(transcript)=2294nt_BP=1520nt
TTATTTACCTGCAGTTGCTTACAAAGTGTTTGGACATAATTGTGTAAAGCTAGGGTTTTTTTTCTGGTTTTTAAAACAGGTAAAGGATGT
CACAGCACCACTTAATAACATTTCTTCTGAAGTCCAGATTTTAACATCTGATGCCAATAAATTAACTGCTGAGAACATCACTAGTGCTAC
GCGAGTGGTTGGACAGATATTCAACACTTCCAGAAATGCTTCACCTGAGGCAAAGAAAGTTGCCATAGTAACAGTGAGTCAACTCCTAGA
TGCCAGTGAAGATGCTTTTCAAAGAGTTGCTGCTACTGCTAATGATGATGCCCTTACAACATTACACCAAGACATGCGGCTTTGTAGTTT
ATCAAAATGACAAGCTTTTCCAATCAAAAACTTTTACAGCTAAATCGGATTTTAGTCAAAAAATTATCTCAAGCAAAACTGATGAAAATG
AGCAAGATCAGAGTGCTTCTGTTGACATGGTCTTTAGTCCAAAGTACAACCAAAAAGAATTTCAACTCTATTCCTATGCCTGTGTCTATT
GGAATTTGTCAGCGAAGGACTGGGACACATATGGCTGTCAAAAAGACAAGGGCACTGATGGATTCCTGCGCTGCCGCTGCAACCATACTA
CTAATTTTGCTGTATTAATGACTTTCAAAAAGGATTATCAATATCCCAAATCACTTGACATATTATCCAACGTTGGATGTGCACTGTCTG
TTACTGGTCTGGCTCTCACAGTTATATTTCAGATTGTCACCAGGAAAGTCAGAAAAACCTCAGTAACCTGGGTTTTGGTCAATCTGTGCA
TATCAATGTTGATTTTCAACCTCCTCTTTGTGTTTGGAATTGAAAACTCCAATAAGAACTTGCAGACAAGTGATGGTGACATCAATAATA
TTGACTTTGACAATAATGACATACCCAGGACAGACACCATTAACATCCCGAATCCCATGTGCACTGCGATTGCCGCCTTACTGCACTATT
TTCTGTTAGTGACATTTACCTGGAACGCACTCAGCGCTGCACAGCTCTATTACCTTCTAATAAGGACCATGAAGCCTCTTCCTCGGCATT
TCATTCTTTTCATCTCATTAATTGGATGGGGAGTCCCAGCTATAGTAGTGGCTATAACAGTGGGAGTTATTTATTCTCAGAATGGAAATA
ATCCACAGTGGGAATTAGACTACCGGCAAGAGAAAATCTGCTGGCTGGCAATTCCAGAACCCAATGGTGTTATAAAAAGTCCGCTGTTGT
GGTCATTCATCGTACCTGTAACCATTATCCTCATCAGCAATGTTGTTATGTTTATTACAATCTCGATCAAAGTGCTGTGGAAGAATAACC
AGAACCTGACAAGCACAAAAAAAGTTTCATCCATGAAGAAGATTGTTAGCACATTATCTGTTGCAGTTGTTTTTGGAATTACCTGGATTC
TAGCATACCTGATGCTAGTTAATGATGATAGCATCAGGATCGTCTTCAGCTACATATTCTGCCTTTTCAACACTACACAGCTTCCTGTGC
TTCCCAGAATTCCATCATCTGACTGCCATCCTAGAAGGCATTCTCATGAGGACCAAGAATTTCGATGCCGTAGCCACGTACGGGATTACA
GAAAATACTCAGAGGATGGGTCATTCAAGGAGCCACTGGAATCAAAAGGAAGATCCCATTCCAAAATTGAGAAATTTTCAGAGTCCTTTG
AACGGCAACTGTGCTTTAGAACCAAGCGTTCTGCCTCTTTGGGACCTGAAAGCAGAAAGGAGAGAAATGAAAGAGAATGCCTGAGGATGG
AGATAAAATCCCGAAAGAAAGTAGAGGAAGAAAGGAGCTCTAGGAAAGAAGAGCATGGAGAAGCACACATGGCTCCCCTGTTTGAAAAAG
GGCCTGAATAATACTCTGCTTCTGCCTCATGACATCAGATGCTACTGTTTTGGTTTTTTTCTTTGAGCCCCAATTCACCATTTCAGGATG
TGGATGGGGGCGGGGTTGGGGGTAAAAACAGCTATAAAAAGCAACTGCAGATGCTGACTGACTGCAGTGGGCAGGGTATGTAGCTGCTCC
AAGATGACTTGCATCATACCCCAATTACTGCTGGCATCTTAGTTGAGAGTATAATCTGCTTGGTTGCCTTTTTATGGGAATAAAGAGAAT
AAAAGGTATTTTAATAGAATAAAGAAAAATTTGAAAATATAATGGAAGGTATTTAAAGAGCCACCCACATAGCTTCACCAACCCTTCTCA

>34372_34372_3_GPR128-LNP1_GPR128_chr3_100387949_ENST00000475887_LNP1_chr3_100170563_ENST00000383693_length(amino acids)=543AA_BP=416
MPVKMLFKELLLLLMMMPLQHYTKTCGFVVYQNDKLFQSKTFTAKSDFSQKIISSKTDENEQDQSASVDMVFSPKYNQKEFQLYSYACVY
WNLSAKDWDTYGCQKDKGTDGFLRCRCNHTTNFAVLMTFKKDYQYPKSLDILSNVGCALSVTGLALTVIFQIVTRKVRKTSVTWVLVNLC
ISMLIFNLLFVFGIENSNKNLQTSDGDINNIDFDNNDIPRTDTINIPNPMCTAIAALLHYFLLVTFTWNALSAAQLYYLLIRTMKPLPRH
FILFISLIGWGVPAIVVAITVGVIYSQNGNNPQWELDYRQEKICWLAIPEPNGVIKSPLLWSFIVPVTIILISNVVMFITISIKVLWKNN
QNLTSTKKVSSMKKIVSTLSVAVVFGITWILAYLMLVNDDSIRIVFSYIFCLFNTTQLPVLPRIPSSDCHPRRHSHEDQEFRCRSHVRDY
RKYSEDGSFKEPLESKGRSHSKIEKFSESFERQLCFRTKRSASLGPESRKERNERECLRMEIKSRKKVEEERSSRKEEHGEAHMAPLFEK

--------------------------------------------------------------
>34372_34372_4_GPR128-LNP1_GPR128_chr3_100387949_ENST00000475887_LNP1_chr3_100170563_ENST00000489752_length(transcript)=2275nt_BP=1520nt
TTATTTACCTGCAGTTGCTTACAAAGTGTTTGGACATAATTGTGTAAAGCTAGGGTTTTTTTTCTGGTTTTTAAAACAGGTAAAGGATGT
CACAGCACCACTTAATAACATTTCTTCTGAAGTCCAGATTTTAACATCTGATGCCAATAAATTAACTGCTGAGAACATCACTAGTGCTAC
GCGAGTGGTTGGACAGATATTCAACACTTCCAGAAATGCTTCACCTGAGGCAAAGAAAGTTGCCATAGTAACAGTGAGTCAACTCCTAGA
TGCCAGTGAAGATGCTTTTCAAAGAGTTGCTGCTACTGCTAATGATGATGCCCTTACAACATTACACCAAGACATGCGGCTTTGTAGTTT
ATCAAAATGACAAGCTTTTCCAATCAAAAACTTTTACAGCTAAATCGGATTTTAGTCAAAAAATTATCTCAAGCAAAACTGATGAAAATG
AGCAAGATCAGAGTGCTTCTGTTGACATGGTCTTTAGTCCAAAGTACAACCAAAAAGAATTTCAACTCTATTCCTATGCCTGTGTCTATT
GGAATTTGTCAGCGAAGGACTGGGACACATATGGCTGTCAAAAAGACAAGGGCACTGATGGATTCCTGCGCTGCCGCTGCAACCATACTA
CTAATTTTGCTGTATTAATGACTTTCAAAAAGGATTATCAATATCCCAAATCACTTGACATATTATCCAACGTTGGATGTGCACTGTCTG
TTACTGGTCTGGCTCTCACAGTTATATTTCAGATTGTCACCAGGAAAGTCAGAAAAACCTCAGTAACCTGGGTTTTGGTCAATCTGTGCA
TATCAATGTTGATTTTCAACCTCCTCTTTGTGTTTGGAATTGAAAACTCCAATAAGAACTTGCAGACAAGTGATGGTGACATCAATAATA
TTGACTTTGACAATAATGACATACCCAGGACAGACACCATTAACATCCCGAATCCCATGTGCACTGCGATTGCCGCCTTACTGCACTATT
TTCTGTTAGTGACATTTACCTGGAACGCACTCAGCGCTGCACAGCTCTATTACCTTCTAATAAGGACCATGAAGCCTCTTCCTCGGCATT
TCATTCTTTTCATCTCATTAATTGGATGGGGAGTCCCAGCTATAGTAGTGGCTATAACAGTGGGAGTTATTTATTCTCAGAATGGAAATA
ATCCACAGTGGGAATTAGACTACCGGCAAGAGAAAATCTGCTGGCTGGCAATTCCAGAACCCAATGGTGTTATAAAAAGTCCGCTGTTGT
GGTCATTCATCGTACCTGTAACCATTATCCTCATCAGCAATGTTGTTATGTTTATTACAATCTCGATCAAAGTGCTGTGGAAGAATAACC
AGAACCTGACAAGCACAAAAAAAGTTTCATCCATGAAGAAGATTGTTAGCACATTATCTGTTGCAGTTGTTTTTGGAATTACCTGGATTC
TAGCATACCTGATGCTAGTTAATGATGATAGCATCAGGATCGTCTTCAGCTACATATTCTGCCTTTTCAACACTACACAGTTCCTGTGCT
TCCCAGAATTCCATCATCTGACTGCCATCCTAGAAGGCATTCTCATGAGGACCAAGAATTTCGATGCCGTAGCCACGTACGGGATTACAG
AAAATACTCAGAGGATGGGTCATTCAAGGAGCCACTGGAATCAAAAGGAAGATCCCATTCCAAAATTGAGAAATTTTCAGAGTCCTTTGA
ACGGCAACTGTGCTTTAGAACCAAGCGTTCTGCCTCTTTGGGACCTGAAAGCAGAAAGGAGAGAAATGAAAGAGAATGCCTGAGGATGGA
GATAAAATCCCGAAAGAAAGTAGAGGAAGAAAGGAGCTCTAGGAAAGAAGAGCATGGAGAAGCACACATGGCTCCCCTGTTTGAAAAAGG
GCCTGAATAATACTCTGCTTCTGCCTCATGACATCAGATGCTACTGTTTTGGTTTTTTTCTTTGAGCCCCAATTCACCATTTCAGGATGT
GGATGGGGGCGGGGTTGGGGGTAAAAACAGCTATAAAAAGCAACTGCAGATGCTGACTGACTGCAGTGGGCAGGGTATGTAGCTGCTCCA
AGATGACTTGCATCATACCCCAATTACTGCTGGCATCTTAGTTGAGAGTATAATCTGCTTGGTTGCCTTTTTATGGGAATAAAGAGAATA
AAAGGTATTTTAATAGAATAAAGAAAAATTTGAAAATATAATGGAAGGTATTTAAAGAGCCACCCACATAGCTTCACCAACCCTTCTCAC

>34372_34372_4_GPR128-LNP1_GPR128_chr3_100387949_ENST00000475887_LNP1_chr3_100170563_ENST00000489752_length(amino acids)=507AA_BP=417
MPVKMLFKELLLLLMMMPLQHYTKTCGFVVYQNDKLFQSKTFTAKSDFSQKIISSKTDENEQDQSASVDMVFSPKYNQKEFQLYSYACVY
WNLSAKDWDTYGCQKDKGTDGFLRCRCNHTTNFAVLMTFKKDYQYPKSLDILSNVGCALSVTGLALTVIFQIVTRKVRKTSVTWVLVNLC
ISMLIFNLLFVFGIENSNKNLQTSDGDINNIDFDNNDIPRTDTINIPNPMCTAIAALLHYFLLVTFTWNALSAAQLYYLLIRTMKPLPRH
FILFISLIGWGVPAIVVAITVGVIYSQNGNNPQWELDYRQEKICWLAIPEPNGVIKSPLLWSFIVPVTIILISNVVMFITISIKVLWKNN
QNLTSTKKVSSMKKIVSTLSVAVVFGITWILAYLMLVNDDSIRIVFSYIFCLFNTTQFLCFPEFHHLTAILEGILMRTKNFDAVATYGIT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GPR128-LNP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GPR128-LNP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GPR128-LNP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource