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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GPR156-FSTL1 (FusionGDB2 ID:34401)

Fusion Gene Summary for GPR156-FSTL1

check button Fusion gene summary
Fusion gene informationFusion gene name: GPR156-FSTL1
Fusion gene ID: 34401
HgeneTgene
Gene symbol

GPR156

FSTL1

Gene ID

165829

11167

Gene nameG protein-coupled receptor 156follistatin like 1
SynonymsGABABL|PGR28FRP|FSL1|MIR198|OCC-1|OCC1|tsc36
Cytomap

3q13.33

3q13.33

Type of geneprotein-codingprotein-coding
Descriptionprobable G-protein coupled receptor 156G protein-coupled receptor PGR28GABAB-related G-protein coupled receptorfollistatin-related protein 1follistatin-like protein 1
Modification date2020031320200313
UniProtAcc

Q8NFN8

Q12841

Ensembl transtripts involved in fusion geneENST00000315843, ENST00000461057, 
ENST00000464295, 		ENST00000424703, 
ENST00000485968, ENST00000295633, 
Fusion gene scores* DoF score3 X 3 X 3=279 X 7 X 6=378
# samples 410
** MAII scorelog2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(10/378*10)=-1.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GPR156 [Title/Abstract] AND FSTL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGPR156(119962487)-FSTL1(120134874), # samples:1
Anticipated loss of major functional domain due to fusion event.GPR156-FSTL1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
GPR156-FSTL1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across GPR156 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FSTL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-KJ-A3U4-01AGPR156chr3

119962487

-FSTL1chr3

120134874

-


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Fusion Gene ORF analysis for GPR156-FSTL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000315843ENST00000424703GPR156chr3

119962487

-FSTL1chr3

120134874

-
5CDS-intronENST00000315843ENST00000485968GPR156chr3

119962487

-FSTL1chr3

120134874

-
5CDS-intronENST00000461057ENST00000424703GPR156chr3

119962487

-FSTL1chr3

120134874

-
5CDS-intronENST00000461057ENST00000485968GPR156chr3

119962487

-FSTL1chr3

120134874

-
5CDS-intronENST00000464295ENST00000424703GPR156chr3

119962487

-FSTL1chr3

120134874

-
5CDS-intronENST00000464295ENST00000485968GPR156chr3

119962487

-FSTL1chr3

120134874

-
Frame-shiftENST00000315843ENST00000295633GPR156chr3

119962487

-FSTL1chr3

120134874

-
Frame-shiftENST00000461057ENST00000295633GPR156chr3

119962487

-FSTL1chr3

120134874

-
In-frameENST00000464295ENST00000295633GPR156chr3

119962487

-FSTL1chr3

120134874

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000464295GPR156chr3119962487-ENST00000295633FSTL1chr3120134874-62026796041542312

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000464295ENST00000295633GPR156chr3119962487-FSTL1chr3120134874-0.455368580.5446314

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Fusion Genomic Features for GPR156-FSTL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GPR156-FSTL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:119962487/chr3:120134874)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPR156

Q8NFN8

FSTL1

Q12841

FUNCTION: Orphan receptor.FUNCTION: Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes. {ECO:0000250|UniProtKB:Q62356}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGPR156chr3:119962487chr3:120134874ENST00000315843-291_4777815.0Topological domainExtracellular
HgeneGPR156chr3:119962487chr3:120134874ENST00000461057-291_4777811.0Topological domainExtracellular
HgeneGPR156chr3:119962487chr3:120134874ENST00000464295-3101_4777815.0Topological domainExtracellular
HgeneGPR156chr3:119962487chr3:120134874ENST00000315843-2948_6877815.0TransmembraneHelical
HgeneGPR156chr3:119962487chr3:120134874ENST00000461057-2948_6877811.0TransmembraneHelical
HgeneGPR156chr3:119962487chr3:120134874ENST00000464295-31048_6877815.0TransmembraneHelical
TgeneFSTL1chr3:119962487chr3:120134874ENST00000295633111144_17821309.0DomainEF-hand 1
TgeneFSTL1chr3:119962487chr3:120134874ENST00000295633111193_22821309.0DomainEF-hand 2
TgeneFSTL1chr3:119962487chr3:120134874ENST00000295633111233_28721309.0DomainNote=VWFC
TgeneFSTL1chr3:119962487chr3:120134874ENST0000029563311130_5321309.0DomainNote=Follistatin-like
TgeneFSTL1chr3:119962487chr3:120134874ENST0000029563311148_10021309.0DomainKazal-like

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGPR156chr3:119962487chr3:120134874ENST00000315843-29354_39077815.0Coiled coilOntology_term=ECO:0000255
HgeneGPR156chr3:119962487chr3:120134874ENST00000461057-29354_39077811.0Coiled coilOntology_term=ECO:0000255
HgeneGPR156chr3:119962487chr3:120134874ENST00000464295-310354_39077815.0Coiled coilOntology_term=ECO:0000255
HgeneGPR156chr3:119962487chr3:120134874ENST00000315843-29600_60377815.0Compositional biasNote=Poly-Arg
HgeneGPR156chr3:119962487chr3:120134874ENST00000315843-29748_75177815.0Compositional biasNote=Poly-Ser
HgeneGPR156chr3:119962487chr3:120134874ENST00000461057-29600_60377811.0Compositional biasNote=Poly-Arg
HgeneGPR156chr3:119962487chr3:120134874ENST00000461057-29748_75177811.0Compositional biasNote=Poly-Ser
HgeneGPR156chr3:119962487chr3:120134874ENST00000464295-310600_60377815.0Compositional biasNote=Poly-Arg
HgeneGPR156chr3:119962487chr3:120134874ENST00000464295-310748_75177815.0Compositional biasNote=Poly-Ser
HgeneGPR156chr3:119962487chr3:120134874ENST00000315843-29108_11877815.0Topological domainExtracellular
HgeneGPR156chr3:119962487chr3:120134874ENST00000315843-29140_16477815.0Topological domainCytoplasmic
HgeneGPR156chr3:119962487chr3:120134874ENST00000315843-29186_22277815.0Topological domainExtracellular
HgeneGPR156chr3:119962487chr3:120134874ENST00000315843-29244_25777815.0Topological domainCytoplasmic
HgeneGPR156chr3:119962487chr3:120134874ENST00000315843-29279_28877815.0Topological domainExtracellular
HgeneGPR156chr3:119962487chr3:120134874ENST00000315843-29310_81477815.0Topological domainCytoplasmic
HgeneGPR156chr3:119962487chr3:120134874ENST00000315843-2969_8677815.0Topological domainCytoplasmic
HgeneGPR156chr3:119962487chr3:120134874ENST00000461057-29108_11877811.0Topological domainExtracellular
HgeneGPR156chr3:119962487chr3:120134874ENST00000461057-29140_16477811.0Topological domainCytoplasmic
HgeneGPR156chr3:119962487chr3:120134874ENST00000461057-29186_22277811.0Topological domainExtracellular
HgeneGPR156chr3:119962487chr3:120134874ENST00000461057-29244_25777811.0Topological domainCytoplasmic
HgeneGPR156chr3:119962487chr3:120134874ENST00000461057-29279_28877811.0Topological domainExtracellular
HgeneGPR156chr3:119962487chr3:120134874ENST00000461057-29310_81477811.0Topological domainCytoplasmic
HgeneGPR156chr3:119962487chr3:120134874ENST00000461057-2969_8677811.0Topological domainCytoplasmic
HgeneGPR156chr3:119962487chr3:120134874ENST00000464295-310108_11877815.0Topological domainExtracellular
HgeneGPR156chr3:119962487chr3:120134874ENST00000464295-310140_16477815.0Topological domainCytoplasmic
HgeneGPR156chr3:119962487chr3:120134874ENST00000464295-310186_22277815.0Topological domainExtracellular
HgeneGPR156chr3:119962487chr3:120134874ENST00000464295-310244_25777815.0Topological domainCytoplasmic
HgeneGPR156chr3:119962487chr3:120134874ENST00000464295-310279_28877815.0Topological domainExtracellular
HgeneGPR156chr3:119962487chr3:120134874ENST00000464295-310310_81477815.0Topological domainCytoplasmic
HgeneGPR156chr3:119962487chr3:120134874ENST00000464295-31069_8677815.0Topological domainCytoplasmic
HgeneGPR156chr3:119962487chr3:120134874ENST00000315843-29119_13977815.0TransmembraneHelical
HgeneGPR156chr3:119962487chr3:120134874ENST00000315843-29165_18577815.0TransmembraneHelical
HgeneGPR156chr3:119962487chr3:120134874ENST00000315843-29223_24377815.0TransmembraneHelical
HgeneGPR156chr3:119962487chr3:120134874ENST00000315843-29258_27877815.0TransmembraneHelical
HgeneGPR156chr3:119962487chr3:120134874ENST00000315843-29289_30977815.0TransmembraneHelical
HgeneGPR156chr3:119962487chr3:120134874ENST00000315843-2987_10777815.0TransmembraneHelical
HgeneGPR156chr3:119962487chr3:120134874ENST00000461057-29119_13977811.0TransmembraneHelical
HgeneGPR156chr3:119962487chr3:120134874ENST00000461057-29165_18577811.0TransmembraneHelical
HgeneGPR156chr3:119962487chr3:120134874ENST00000461057-29223_24377811.0TransmembraneHelical
HgeneGPR156chr3:119962487chr3:120134874ENST00000461057-29258_27877811.0TransmembraneHelical
HgeneGPR156chr3:119962487chr3:120134874ENST00000461057-29289_30977811.0TransmembraneHelical
HgeneGPR156chr3:119962487chr3:120134874ENST00000461057-2987_10777811.0TransmembraneHelical
HgeneGPR156chr3:119962487chr3:120134874ENST00000464295-310119_13977815.0TransmembraneHelical
HgeneGPR156chr3:119962487chr3:120134874ENST00000464295-310165_18577815.0TransmembraneHelical
HgeneGPR156chr3:119962487chr3:120134874ENST00000464295-310223_24377815.0TransmembraneHelical
HgeneGPR156chr3:119962487chr3:120134874ENST00000464295-310258_27877815.0TransmembraneHelical
HgeneGPR156chr3:119962487chr3:120134874ENST00000464295-310289_30977815.0TransmembraneHelical
HgeneGPR156chr3:119962487chr3:120134874ENST00000464295-31087_10777815.0TransmembraneHelical


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Fusion Gene Sequence for GPR156-FSTL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>34401_34401_1_GPR156-FSTL1_GPR156_chr3_119962487_ENST00000464295_FSTL1_chr3_120134874_ENST00000295633_length(transcript)=6202nt_BP=679nt
GGGGACCGTGGGCGTCCTGCACATAGCAGCGGGCTTGGCGCTTCTCGGCGGTCCGACGCTGATGAGGAACCAGAGTGAGGGTACTCGAAC
AGTGACTGCCATCTGGTGGTTAACCAGAATCATCACCTTGTGTAGCCTGATGGTTACTAAGATGTCCACTCTTGACTCACATGGCATGCA
CTCGCAGCAGGGGACCAGTTGAAGGATGTCTGACTTTGGAGGGTCACCAGTTGAAGGATGTCTGATGAAGGAGCCTAGCGAAATAACCCT
TTGCTTCTACCTGAATGGGTTGTTCACTCTGGATTCTGAGCCTGCAGCCAGCTCCAAAATGGGGCCTCTGAAGAAAAGATTTGAGTTGCT
CTTGTGTCTTAGTCAAAGATCTACATCCCTACCAGTGGGTAACCAAGACTGTGAATAAGCACACACCAACAGGGGCATGTGGTGACATGG
AGCCTGAAATAAACTGCTCTGAATTGTGTGACAGTTTTCCTGGCCAGGAGCTGGATCGGAGACCCCTTCATGATCTCTGCAAGACAACAA
TTACATCTTCCCACCACAGCAGTAAGACCATCTCTTCATTATCTCCTGTCCTCTTGGGTATTGTTTGGACTTTTCTCAGCTGTGGACTTC
TGCTGATACTTTTCTTTCTTGCCTTTACAATTCACTGCAGGAAGAACAGGAAGAGCTAAGGAGCAAATCCAAGATCTGTGCCAATGTGTT
TTGTGGAGCCGGCCGGGAATGTGCAGTCACAGAGAAAGGGGAACCCACCTGTCTCTGCATTGAGCAATGCAAACCTCACAAGAGGCCTGT
GTGTGGCAGTAATGGCAAGACCTACCTCAACCACTGTGAACTGCATCGAGATGCCTGCCTCACTGGATCCAAAATCCAGGTTGATTACGA
TGGACACTGCAAAGAGAAGAAATCCGTAAGTCCATCTGCCAGCCCAGTTGTTTGCTATCAGTCCAACCGTGATGAGCTCCGACGTCGCAT
CATCCAGTGGCTGGAAGCTGAGATCATTCCAGATGGCTGGTTCTCTAAAGGCAGCAACTACAGTGAAATCCTAGACAAGTATTTTAAGAA
CTTTGATAATGGTGATTCTCGCCTGGACTCCAGTGAATTCCTGAAGTTTGTGGAACAGAATGAAACTGCCATCAATATTACAACGTATCC
AGACCAGGAGAACAACAAGTTGCTTAGGGGACTCTGTGTTGATGCTCTCATTGAACTGTCTGATGAAAATGCTGATTGGAAACTCAGCTT
CCAAGAGTTTCTCAAGTGCCTCAACCCATCTTTCAACCCTCCTGAGAAGAAGTGTGCCCTGGAGGATGAAACGTATGCAGATGGAGCTGA
GACCGAGGTGGACTGTAACCGCTGTGTCTGTGCCTGTGGAAATTGGGTCTGTACAGCCATGACCTGTGACGGAAAGAATCAGAAGGGGGC
CCAGACCCAGACAGAGGAGGAGATGACCAGATATGTCCAGGAGCTCCAAAAGCATCAGGAAACAGCTGAAAAGACCAAGAGAGTGAGCAC
CAAAGAGATCTAATGAGGAGGCACAGACCAGTGTCTGGATCCCAGCATCTTCTCCACTTCAGCGCTGAGTTCAGTATACACAAGTGTCTG
CTACAGTCGCCAAATCACCAGTATTTGCTTATATAGCAATGAGTTTTATTTTGTTTATTTGTTTTGCAATAAAGGATATGAAGGTGGCTG
GCTAGGAAGGGAAGGGCCACAGCCTTCATTTCTAGGAGTGCTTTAAGAGAAACTGTAAATGGTGCTCTGGGGCTGGAGGCTAGTAAGGAA
ACTGCATCACGATTGAAAGAGGAACAGACCCAAATCTGAACCTCTTTTGAGTTTACTGCATCTGTCAGCAGGCTGCAGGGAGTGCACACG
ATGCCAGAGAGAACTTAGCAGGGTGTCCCCGGAGGAGAGGTTTGGGAAGCTCCACGGAGAGGAACGCTCTCTGCTTCCAGCCTCTTTCCA
TTGCCGTCAGCATGACAGACCTCCAGCATCCACGCATCTCTTGGTCCCAATAACTGCCTCTAGATACATAGCCATACTGCTAGTTAACCC
AGTGTCCCTCAGACTTGGATGGAGTTTCTGGGAGGGTACACCCAAATGATGCAGATACTTGTATACTTTGAGCCCCTTAGCGACCTAACC
AAATTTTAAAAATACTTTTTACCAAAGGTGCTATTTCTCTGTAAAACACTTTTTTTTGGCAAGTTGACTTTATTCTTCAATTATTATCAT
TATATTATTGTTTTTTAATATTTTATTTTCTTGACTAGGTATTAAGCTTTTGTAATTATTTTTCAGTAGTCCCACCACTTCATAGGTGGA
AGGAGTTTGGGGTTCTTCCTGGTGCAGGGGCTGAAATAACCCAGATGCCCCCACCCTGCCACATACTAGATGCAGCCCATAGTTGGCCCC
CCTAGCTTCCAGCAGTCCACTATCTGCCAGAGGAGCAAGGGTGCCTTAGACCGAAGCCAGGGGAAGAAGCATCTTCATAAAAAACTTTCA
AGATCCAAACATTAATTTGTTTTTATTTATTCTGAGAAGTTGAGGCAAATCAGTATTCCCAAGGATGGCGACAAGGGCAGCCAAGCAGGG
CTTAGGATATCCCAGCCTACCAATATGCTCATTCGACTAACTAGGAGGGTGAGTTGGCCCTGTCTCTTCTTTTTTCTGGACCTCAGTTTC
CTCAGTGAGCTGGTAAGAATGCACTAACCTTTTGATTTGATAAGTTATAAATTCTGTGGTTCTGATCATTGGTCCAGAGGGGAGATAGGT
TCCTGTGATTTTTCCTTCTTCTCTATAGAATAAATGAAATCTTGTTACTAGAACAAGAAATGTCAGATGGCCAAAAACAAGATGACCAGA
TTTGATCTCAGCCTGATGACCCTACAGGTCGTGCTATGATATGGAGTCCTCATGGGTAAAGCAGGAAGAGAGTGGGAAAGAGAACCACCC
CACTCTGTCTTCATATTTGCATTTCATGTTTAACCTCCGGCTGGAAATAGAAAGCATTCCCTTAGAGATGAGGATAAAAGAAAGTTTCAG
ATTCAACAGGGGGAAGAAAATGGAGATTTAATCCTAAAACTGTGACTTGGGGAGGTCAGTCATTTACAGTTAGTCCTGTGTCTTTCGACT
TCTGTGATTATTAACCCCACTCACTACCCTGTTTCAGATGCATTTGGAATACCAAAGATTAAATCCTTGACATAAGATCTCATTTGCAGA
AAGCAGATTAAAGACCATCAGAAGGAAATTATTTAGGTTGTAATGCACAGGCAACTGTGAGAAACTGTTGTGCCAAAAATAGAATTCCTT
CTAGTTTTTCTTGTTCTCATTTGAAAGGAGAAAATTCCACTTTGTTTAGCATTTCAAGCTTTTATGTATCCATCCCATCTAAAAACTCTT
CAAACTCCACTTGTTCAGTCTGAAATGCAGCTCCCTGTCCAAGTGCCTTGGAGAACTCACAGCAGCACGCCTTAATCAAAGGTTTTACCA
GCCCTTGGACACTATGGGAGGAGGGCAAGAGTACACCAATTTGTTAAAAGCAAGAAACCACAGTGTCTCTTCACTAGTCATTTAGAACAT
GGTTATCATCCAAGACTACTCTACCCTGCAACATTGAACTCCCAAGAGCAAATCCACATTCCTCTTGAGTTCTGCAGCTTCTGTGTAAAT
AGGGCAGCTGTCGTCTATGCCGTAGAATCACATGATCTGAGGACCATTCATGGAAGCTGCTAAATAGCCTAGTCTGGGGAGTCTTCCATA
AAGTTTTGCATGGAGCAAACAAACAGGATTAAACTAGGTTTGGTTCCTTCAGCCCTCTAAAAGCATAGGGCTTAGCCTGCAGGCTTCCTT
GGGCTTTCTCTGTGTGTGTAGTTTTGTAAACACTATAGCATCTGTTAAGATCCAGTGTCCATGGAAACATTCCCACATGCCGTGACTCTG
GACTATATCAGTTTTTGGAAAGCAGGGTTCCTCTGCCTGCTAACAAGCCCACGTGGACCAGTCTGAATGTCTTTCCTTTACACCTATGTT
TTTAAGTAGTCAAACTTCAAGAAACAATCTAAACAAGTTTCTGTTGCATATGTGTTTGTGAACTTGTATTTGTATTTAGTAGGCTTCTAT
ATTGCATTTAACTTGTTTTTGTAACTCCTGATTCTTCCTTTTCGGATACTATTGATGAATAAAGAAATTAAAGTGATGGTTTTATTGGTT
TCCTTTCCCCCAATTAAGGCCAAATAAAGTCGTGAGAACATTACCCATTTACTTCCTAAGAGTGGATTTGAGTTTCAGGAGCCTTAAAAA
GGACTGAAGAGTTTCTCCTGGGACTACAGCTTGGATGGAAAGTTTACTCGGGGACTGGTAGAACAAGTTTCTTTGAAAGGATCATGGATA
GTGGGTCTGGAGTAGAAGGTGATGACAAGTCAGAAAGTGTCTTAGTCCCTTCAAGTTGCTATAACAAAATGCCTCAGACTGGGTAATTAT
AGGCAACAGAAATGTATTGCTCACAGTTCTGAAGGCTGGGAAGCCTAAGATCAAGGTACCAGCAGATTCAGTGTCTGATGACGGCTTGTT
GAAGCTTGCCTGCTTCAAAGAATGCACCTTTTTGATGCATCCCCACATGGTGAAAAGGGTGAACAAACTCCCTTAGGCCTCTTTTATAAG
GGCACTTACCCATTCATGAGGGTTAAACTTTGATGACCTAATCATCTCCCAAGAGCCTCACCTCTCAATACCATTGCTTTGGGGATTCAA
TTTTAACATATGAATTTTGGGGGACATAAACATTCAAACCATAGCAGGTGCATTCCTGTATTGGGAAGACATTAAATTAAATGACTCGTA
AATCCCCCATATGATTTAGGAGACTAAATGGCATCCAGTGAGGCTGACTGCAGTAGCCTGTGAGAAGGCAAATAAACATGGGAAGGTAGT
ACAGGGAACATGGAATCATTGCCAGGGACAGGCTAAATAACCTTAATGGCACTTCCTTGATACACACATTCCATGGGGGTAAACAGTTCC
AAGTGGGCTGAACGTTAGCTGGTTAAAACCTCTTTTGCTTGGGGACACATGACTAACGCTTTCCAACCTGCCATTTTCATATGTATCATG
CACTCTCCACCCACAATAATTCTGCCTCCCAAAAGAGCATATTATAGTCAATGAGGTTTAAGGTTTCTTCGGTTCAGTCATGTGGAAGTT
TTGCTTTCCTAAAATTATAGCTGGATCACTTTGATTGGATTTGGGATATTACCCAAATGCTAATCAAATATTAAAAGGCAATCTTTTTTG
TTATGTGATTGCTACAGATTACTGCTCTTACAGTTTGATTCTTCAAATTTTCATTCTCAGAAGGGAATCTTAAACCCAGTTTGAAGGGTA
CCTTGTCCACAACCACTTTTAAATTTTGGCTAACTTCCCAACCTTCCACCATGTTCTGGGAAAACTTTTTCTGCTGTTATAGTATGTATG
TATTCAGGAAGTGCAACATTATTAAACTAAGCATAATTCAGAAGCTAAGTTTCCTTTCATCAAAATTTAATATTACGAATTGTGCAAAGA
AGTATGTTACTTTGATCAGCTTTATTTTAGAGCTTCTTTATCAAGTTATCATCAGTCCTCTTGAATTATTTCTGAAATAAGGGGAAGGAA
GGAAGGGAAAAAATATGAATGCATAGATAGATCTAAGCAGATGCCTTCAGAGCCCTGGAATAATCCTAGCTGGGATATGGGACATGAAAA
CAACTCTGGCCTACTGCTGCTGGGGGCTGTTGCATGGTGTGACATAGGAAGTAAAATGTTGCTGTATGAATAGGAAGGAGGGTCTTCCTG
TCAATGAGAATTAATGTTTTCCTAATGATTTAACTTTTTTACTGAAAAAATAATATGTGTACATGGTAAAAATCCAAATTGTATCACAGA
AAATACAGTGAATAAAACCATCCTCTTAAGAGGGTGTGTACATTTATAAATTTGCCTATGATTGCCTATAAAGTCAAAGAAGTTGCACCA
GTATGCATGACTGCCAAAAGTACATAAACTGAGCATATCCATTTCCCTACATTCTTGCAAACATTGTGCCTTCGAACTTTTTGGCCTCTG

>34401_34401_1_GPR156-FSTL1_GPR156_chr3_119962487_ENST00000464295_FSTL1_chr3_120134874_ENST00000295633_length(amino acids)=312AA_BP=25
MDFSQLWTSADTFLSCLYNSLQEEQEELRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLT
GSKIQVDYDGHCKEKKSVSPSASPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSKGSNYSEILDKYFKNFDNGDSRLDSSEFLKFVEQNE
TAINITTYPDQENNKLLRGLCVDALIELSDENADWKLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMT

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Fusion Gene PPI Analysis for GPR156-FSTL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GPR156-FSTL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GPR156-FSTL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource