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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GPR157-TLE6 (FusionGDB2 ID:34406)

Fusion Gene Summary for GPR157-TLE6

Fusion gene summary

Fusion gene information	Fusion gene name: GPR157-TLE6
	Fusion gene ID: 34406
		Hgene	Tgene
	Gene symbol	GPR157	TLE6
	Gene ID	80045	79816
	Gene name	G protein-coupled receptor 157	TLE family member 6, subcortical maternal complex member
	Synonyms	-	GRG6\|PREMBL
	Cytomap	1p36.22	19p13.3
	Type of gene	protein-coding	protein-coding
	Description	G-protein coupled receptor 157probable G-protein coupled receptor 157	transducin-like enhancer protein 6transducin like enhancer of split 6transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000377411, ENST00000414642,	ENST00000452088, ENST00000478073, ENST00000482627, ENST00000246112,
Fusion gene scores	* DoF score	3 X 2 X 3=18	5 X 5 X 5=125
	# samples	3	7
	** MAII score	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(7/125*10)=-0.836501267717121 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GPR157 [Title/Abstract] AND TLE6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GPR157(9188704)-TLE6(2980098), # samples:1
Anticipated loss of major functional domain due to fusion event.	GPR157-TLE6 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. GPR157-TLE6 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across GPR157 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TLE6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-06-0190-02A	GPR157	chr1	9188704	-	TLE6	chr19	2980098	+

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Fusion Gene ORF analysis for GPR157-TLE6

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000377411	ENST00000452088	GPR157	chr1	9188704	-	TLE6	chr19	2980098	+
5CDS-5UTR	ENST00000414642	ENST00000452088	GPR157	chr1	9188704	-	TLE6	chr19	2980098	+
5CDS-intron	ENST00000377411	ENST00000478073	GPR157	chr1	9188704	-	TLE6	chr19	2980098	+
5CDS-intron	ENST00000414642	ENST00000478073	GPR157	chr1	9188704	-	TLE6	chr19	2980098	+
Frame-shift	ENST00000377411	ENST00000482627	GPR157	chr1	9188704	-	TLE6	chr19	2980098	+
Frame-shift	ENST00000414642	ENST00000482627	GPR157	chr1	9188704	-	TLE6	chr19	2980098	+
In-frame	ENST00000377411	ENST00000246112	GPR157	chr1	9188704	-	TLE6	chr19	2980098	+
In-frame	ENST00000414642	ENST00000246112	GPR157	chr1	9188704	-	TLE6	chr19	2980098	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000377411

GPR157

chr1

9188704

ENST00000246112

TLE6

chr19

2980098

2369

526

2193

718

ENST00000414642

GPR157

chr1

9188704

ENST00000246112

TLE6

chr19

2980098

2323

480

330

2147

605

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000377411	ENST00000246112	GPR157	chr1	9188704	-	TLE6	chr19	2980098	+	0.110671744	0.88932824
ENST00000414642	ENST00000246112	GPR157	chr1	9188704	-	TLE6	chr19	2980098	+	0.1149181	0.8850819

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Fusion Genomic Features for GPR157-TLE6

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
GPR157	chr1	9188703	-	TLE6	chr19	2980097	+	5.96E-05	0.9999404
GPR157	chr1	9188703	-	TLE6	chr19	2980097	+	5.96E-05	0.9999404

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GPR157-TLE6

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:9188704/chr19:2980098)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GPR157

chr1:9188704

chr19:2980098

ENST00000377411

109_119

127

336.0

Topological domain

Cytoplasmic

Hgene

GPR157

chr1:9188704

chr19:2980098

ENST00000377411

1_15

127

336.0

Topological domain

Extracellular

Hgene

GPR157

chr1:9188704

chr19:2980098

ENST00000377411

37_48

127

336.0

Topological domain

Cytoplasmic

Hgene

GPR157

chr1:9188704

chr19:2980098

ENST00000377411

70_87

127

336.0

Topological domain

Extracellular

Hgene

GPR157

chr1:9188704

chr19:2980098

ENST00000377411

16_36

127

336.0

Transmembrane

Helical%3B Name%3D1

Hgene

GPR157

chr1:9188704

chr19:2980098

ENST00000377411

49_69

127

336.0

Transmembrane

Helical%3B Name%3D2

Hgene

GPR157

chr1:9188704

chr19:2980098

ENST00000377411

88_108

127

336.0

Transmembrane

Helical%3B Name%3D3

Tgene

TLE6

chr1:9188704

chr19:2980098

ENST00000246112

284_322

573.0

Repeat

Note=WD 1

Tgene

TLE6

chr1:9188704

chr19:2980098

ENST00000246112

332_372

573.0

Repeat

Note=WD 2

Tgene

TLE6

chr1:9188704

chr19:2980098

ENST00000246112

377_416

573.0

Repeat

Note=WD 3

Tgene

TLE6

chr1:9188704

chr19:2980098

ENST00000246112

419_456

573.0

Repeat

Note=WD 4

Tgene

TLE6

chr1:9188704

chr19:2980098

ENST00000246112

458_497

573.0

Repeat

Note=WD 5

Tgene

TLE6

chr1:9188704

chr19:2980098

ENST00000246112

499_538

573.0

Repeat

Note=WD 6

Tgene

TLE6

chr1:9188704

chr19:2980098

ENST00000246112

540_571

573.0

Repeat

Note=WD 7

Tgene

TLE6

chr1:9188704

chr19:2980098

ENST00000452088

284_322

450.0

Repeat

Note=WD 1

Tgene

TLE6

chr1:9188704

chr19:2980098

ENST00000452088

332_372

450.0

Repeat

Note=WD 2

Tgene

TLE6

chr1:9188704

chr19:2980098

ENST00000452088

377_416

450.0

Repeat

Note=WD 3

Tgene

TLE6

chr1:9188704

chr19:2980098

ENST00000452088

419_456

450.0

Repeat

Note=WD 4

Tgene

TLE6

chr1:9188704

chr19:2980098

ENST00000452088

458_497

450.0

Repeat

Note=WD 5

Tgene

TLE6

chr1:9188704

chr19:2980098

ENST00000452088

499_538

450.0

Repeat

Note=WD 6

Tgene

TLE6

chr1:9188704

chr19:2980098

ENST00000452088

540_571

450.0

Repeat

Note=WD 7

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GPR157

chr1:9188704

chr19:2980098

ENST00000377411

294_298

127

336.0

Compositional bias

Note=Poly-Cys

Hgene

GPR157

chr1:9188704

chr19:2980098

ENST00000377411

141_166

127

336.0

Topological domain

Extracellular

Hgene

GPR157

chr1:9188704

chr19:2980098

ENST00000377411

188_226

127

336.0

Topological domain

Cytoplasmic

Hgene

GPR157

chr1:9188704

chr19:2980098

ENST00000377411

248_258

127

336.0

Topological domain

Extracellular

Hgene

GPR157

chr1:9188704

chr19:2980098

ENST00000377411

280_335

127

336.0

Topological domain

Cytoplasmic

Hgene

GPR157

chr1:9188704

chr19:2980098

ENST00000377411

120_140

127

336.0

Transmembrane

Helical%3B Name%3D4

Hgene

GPR157

chr1:9188704

chr19:2980098

ENST00000377411

167_187

127

336.0

Transmembrane

Helical%3B Name%3D5

Hgene

GPR157

chr1:9188704

chr19:2980098

ENST00000377411

227_247

127

336.0

Transmembrane

Helical%3B Name%3D6

Hgene

GPR157

chr1:9188704

chr19:2980098

ENST00000377411

259_279

127

336.0

Transmembrane

Helical%3B Name%3D7

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Fusion Gene Sequence for GPR157-TLE6

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>34406_34406_1_GPR157-TLE6_GPR157_chr1_9188704_ENST00000377411_TLE6_chr19_2980098_ENST00000246112_length(transcript)=2369nt_BP=526nt
GGGCGGGGGAGCGGCCGGACGCGGGCGGGGCGGGCGCCTGGACGCGAGCCTAGGGCGCCTCGGTGCCCAGACGGCGGCGGCGTGGCCGCA
CGCGCGGCCCGGCTTCTGTCCTCGCGGCGCTCCGGCTCCTGGCCCCCCACGCCATGCAGCCGTCCCCGCCGCCCACCGAGCTGGTGCCGT
CGGAGCGCGCCGTGGTGCTGCTGTCGTGCGCACTCTCCGCGCTCGGCTCGGGCCTGCTGGTGGCCACGCACGCCCTGTGGCCCGACCTGC
GCAGCCGGGCACGGCGCCTGCTGCTCTTCCTGTCGCTGGCCGACCTGCTCTCGGCCGCCTCCTACTTCTACGGAGTGCTGCAGAACTTCG
CGGGCCCGTCGTGGGACTGCGTGCTGCAGGGCGCGCTGTCCACCTTCGCCAACACCAGCTCCTTCTTCTGGACCGTGGCCATTGCGCTCT
ACTTGTACCTCAGCATCGTCCGCGCCGCGCGCGGGCCTCGCACAGATCGCCTGCTTTGGGCCTTCCATGTCGTCAGCCTTGTCCTGGGAT
CTCGAACTCTGAGAGCTCTCCGACGCTGAATTATCAGGGCATTCTAAATCGGCTCAAGCAGTTCCCCAGGTTTTCTCCTCATTTTGCTGC
GGAGTTGGAGAGCATTTACTACTCGCTGCACAAGATCCAGCAGGATGTGGCAGAACATCACAAGCAGATAGGAAACGTCTTACAGATTGT
GGAGAGCTGCAGCCAACTCCAGGGTTTCCAGTCTGAGGAGGTCTCACCTGCTGAACCAGCCAGCCCTGGGACGCCCCAGCAGGTGAAGGA
CAAGACCCTGCAGGAGTCGAGCTTTGAGGACATCATGGCCACCAGGTCCTCCGACTGGCTCCGGCGGCCTTTGGGGGAGGACAATCAGCC
GGAGACCCAGCTGTTCTGGGACAAGGAGCCTTGGTTTTGGCACGACACTCTGACCGAGCAACTCTGGCGGATTTTTGCCGGCGTCCACGA
TGAGAAGGCAAAGCCCAGAGACAGACAGCAGGCACCAGGCCTGGGGCAGGAAAGCAAGGCACCAGGATCCTGTGACCCAGGAACAGACCC
ATGTCCTGAAGATGCCTCCACCCCCAGGCCACCTGAGGCCTCCTCCAGTCCCCCTGAGGGTTCCCAAGACAGGAACACAAGTTGGGGTGT
GGTCCAGGAGCCTCCTGGAAGAGCCTCTCGGTTTCTACAGTCCATATCCTGGGACCCTGAGGACTTTGAAGATGCATGGAAGAGGCCAGA
TGCCTTGCCCGGGCAGTCAAAGAGACTCGCCGTCCCGTGCAAACTGGAAAAGATGCGGATCTTGGCACACGGGGAGCTCGTGCTCGCCAC
GGCCATCAGCAGCTTCACGCGGCACGTGTTCACCTGTGGCAGAAGAGGCATCAAGGTGTGGAGCCTGACTGGACAGGTGGCTGAGGACAG
GTTCCCTGAGAGCCACCTGCCTATACAGACCCCTGGGGCCTTCCTGCGCACCTGCCTGCTGTCCTCAAACAGCAGGAGCCTGCTCACCGG
TGGCTACAACCTGGCCAGCGTGAGCGTGTGGGACCTGGCGGCGCCCTCCCTGCATGTGAAGGAGCAGTTGCCCTGTGCAGGTCTCAACTG
CCAGGCCCTGGATGCCAACCTGGATGCCAACCTGGCCTTCGCCAGCTTCACCAGTGGTGTGGTCAGGATCTGGGACCTGCGGGATCAGAG
TGTGGTCAGGGACCTCAAGGGTTATCCTGATGGAGTCAAGAGTATCGTGGTCAAGGGCTACAACATCTGGACTGGGGGTCCGGATGCCTG
TCTGCGGTGCTGGGACCAGAGGACCATCATGAAACCTCTGGAGTACCAATTCAAGTCTCAGATAATGAGCCTGTCCCACAGCCCCCAGGA
GGACTGGGTGCTGCTGGGCATGGCCAATGGCCAGCAGTGGCTGCAAAGCACCAGCGGGAGCCAGCGGCACATGGTGGGGCAAAAAGACAG
CGTCATCCTGAGCGTCAAGTTCTCCCCCTTTGGCCAGTGGTGGGCAAGCGTTGGAATGGACGACTTCCTTGGCGTCTACAGCATGCCGGC
GGGGACAAAAGTGTTCGAGGTGCCTGAGATGTCTCCAGTCACGTGCTGTGACGTCTCTTCCAACAACCGCCTCGTTGTCACAGGCTCCGG
GGAGCACGCCTCCGTGTACCAGATCACCTACTGAGGGGCCTCGCTGCTGTCATCCCACTCCGGCTCCTCTTTTCATCCCCCCCCTTCCCC
CCCCCCAACAAGGGGGACATGGTGGAGGGAAGCGGGAAGGCTCTTCTGTGGCATCGCACGATCTAGTCTGTGGTGTAGACTGGTCGCCAT

>34406_34406_1_GPR157-TLE6_GPR157_chr1_9188704_ENST00000377411_TLE6_chr19_2980098_ENST00000246112_length(amino acids)=718AA_BP=162
MDASLGRLGAQTAAAWPHARPGFCPRGAPAPGPPRHAAVPAAHRAGAVGARRGAAVVRTLRARLGPAGGHARPVARPAQPGTAPAALPVA
GRPALGRLLLLRSAAELRGPVVGLRAAGRAVHLRQHQLLLLDRGHCALLVPQHRPRRARASHRSPALGLPCRQPCPGISNSESSPTLNYQ
GILNRLKQFPRFSPHFAAELESIYYSLHKIQQDVAEHHKQIGNVLQIVESCSQLQGFQSEEVSPAEPASPGTPQQVKDKTLQESSFEDIM
ATRSSDWLRRPLGEDNQPETQLFWDKEPWFWHDTLTEQLWRIFAGVHDEKAKPRDRQQAPGLGQESKAPGSCDPGTDPCPEDASTPRPPE
ASSSPPEGSQDRNTSWGVVQEPPGRASRFLQSISWDPEDFEDAWKRPDALPGQSKRLAVPCKLEKMRILAHGELVLATAISSFTRHVFTC
GRRGIKVWSLTGQVAEDRFPESHLPIQTPGAFLRTCLLSSNSRSLLTGGYNLASVSVWDLAAPSLHVKEQLPCAGLNCQALDANLDANLA
FASFTSGVVRIWDLRDQSVVRDLKGYPDGVKSIVVKGYNIWTGGPDACLRCWDQRTIMKPLEYQFKSQIMSLSHSPQEDWVLLGMANGQQ

--------------------------------------------------------------
>34406_34406_2_GPR157-TLE6_GPR157_chr1_9188704_ENST00000414642_TLE6_chr19_2980098_ENST00000246112_length(transcript)=2323nt_BP=480nt
AGCCTAGGGCGCCTCGGTGCCCAGACGGCGGCGGCGTGGCCGCACGCGCGGCCCGGCTTCTGTCCTCGCGGCGCTCCGGCTCCTGGCCCC
CCACGCCATGCAGCCGTCCCCGCCGCCCACCGAGCTGGTGCCGTCGGAGCGCGCCGTGGTGCTGCTGTCGTGCGCACTCTCCGCGCTCGG
CTCGGGCCTGCTGGTGGCCACGCACGCCCTGTGGCCCGACCTGCGCAGCCGGGCACGGCGCCTGCTGCTCTTCCTGTCGCTGGCCGACCT
GCTCTCGGCCGCCTCCTACTTCTACGGAGTGCTGCAGAACTTCGCGGGCCCGTCGTGGGACTGCGTGCTGCAGGGCGCGCTGTCCACCTT
CGCCAACACCAGCTCCTTCTTCTGGACCGTGGCCATTGCGCTCTACTTGTACCTCAGCATCGTCCGCGCCGCGCGCGGGCCTCGCACAGA
TCGCCTGCTTTGGGCCTTCCATGTCGTCAGCCTTGTCCTGGGATCTCGAACTCTGAGAGCTCTCCGACGCTGAATTATCAGGGCATTCTA
AATCGGCTCAAGCAGTTCCCCAGGTTTTCTCCTCATTTTGCTGCGGAGTTGGAGAGCATTTACTACTCGCTGCACAAGATCCAGCAGGAT
GTGGCAGAACATCACAAGCAGATAGGAAACGTCTTACAGATTGTGGAGAGCTGCAGCCAACTCCAGGGTTTCCAGTCTGAGGAGGTCTCA
CCTGCTGAACCAGCCAGCCCTGGGACGCCCCAGCAGGTGAAGGACAAGACCCTGCAGGAGTCGAGCTTTGAGGACATCATGGCCACCAGG
TCCTCCGACTGGCTCCGGCGGCCTTTGGGGGAGGACAATCAGCCGGAGACCCAGCTGTTCTGGGACAAGGAGCCTTGGTTTTGGCACGAC
ACTCTGACCGAGCAACTCTGGCGGATTTTTGCCGGCGTCCACGATGAGAAGGCAAAGCCCAGAGACAGACAGCAGGCACCAGGCCTGGGG
CAGGAAAGCAAGGCACCAGGATCCTGTGACCCAGGAACAGACCCATGTCCTGAAGATGCCTCCACCCCCAGGCCACCTGAGGCCTCCTCC
AGTCCCCCTGAGGGTTCCCAAGACAGGAACACAAGTTGGGGTGTGGTCCAGGAGCCTCCTGGAAGAGCCTCTCGGTTTCTACAGTCCATA
TCCTGGGACCCTGAGGACTTTGAAGATGCATGGAAGAGGCCAGATGCCTTGCCCGGGCAGTCAAAGAGACTCGCCGTCCCGTGCAAACTG
GAAAAGATGCGGATCTTGGCACACGGGGAGCTCGTGCTCGCCACGGCCATCAGCAGCTTCACGCGGCACGTGTTCACCTGTGGCAGAAGA
GGCATCAAGGTGTGGAGCCTGACTGGACAGGTGGCTGAGGACAGGTTCCCTGAGAGCCACCTGCCTATACAGACCCCTGGGGCCTTCCTG
CGCACCTGCCTGCTGTCCTCAAACAGCAGGAGCCTGCTCACCGGTGGCTACAACCTGGCCAGCGTGAGCGTGTGGGACCTGGCGGCGCCC
TCCCTGCATGTGAAGGAGCAGTTGCCCTGTGCAGGTCTCAACTGCCAGGCCCTGGATGCCAACCTGGATGCCAACCTGGCCTTCGCCAGC
TTCACCAGTGGTGTGGTCAGGATCTGGGACCTGCGGGATCAGAGTGTGGTCAGGGACCTCAAGGGTTATCCTGATGGAGTCAAGAGTATC
GTGGTCAAGGGCTACAACATCTGGACTGGGGGTCCGGATGCCTGTCTGCGGTGCTGGGACCAGAGGACCATCATGAAACCTCTGGAGTAC
CAATTCAAGTCTCAGATAATGAGCCTGTCCCACAGCCCCCAGGAGGACTGGGTGCTGCTGGGCATGGCCAATGGCCAGCAGTGGCTGCAA
AGCACCAGCGGGAGCCAGCGGCACATGGTGGGGCAAAAAGACAGCGTCATCCTGAGCGTCAAGTTCTCCCCCTTTGGCCAGTGGTGGGCA
AGCGTTGGAATGGACGACTTCCTTGGCGTCTACAGCATGCCGGCGGGGACAAAAGTGTTCGAGGTGCCTGAGATGTCTCCAGTCACGTGC
TGTGACGTCTCTTCCAACAACCGCCTCGTTGTCACAGGCTCCGGGGAGCACGCCTCCGTGTACCAGATCACCTACTGAGGGGCCTCGCTG
CTGTCATCCCACTCCGGCTCCTCTTTTCATCCCCCCCCTTCCCCCCCCCCAACAAGGGGGACATGGTGGAGGGAAGCGGGAAGGCTCTTC

>34406_34406_2_GPR157-TLE6_GPR157_chr1_9188704_ENST00000414642_TLE6_chr19_2980098_ENST00000246112_length(amino acids)=605AA_BP=49
MRAAGRAVHLRQHQLLLLDRGHCALLVPQHRPRRARASHRSPALGLPCRQPCPGISNSESSPTLNYQGILNRLKQFPRFSPHFAAELESI
YYSLHKIQQDVAEHHKQIGNVLQIVESCSQLQGFQSEEVSPAEPASPGTPQQVKDKTLQESSFEDIMATRSSDWLRRPLGEDNQPETQLF
WDKEPWFWHDTLTEQLWRIFAGVHDEKAKPRDRQQAPGLGQESKAPGSCDPGTDPCPEDASTPRPPEASSSPPEGSQDRNTSWGVVQEPP
GRASRFLQSISWDPEDFEDAWKRPDALPGQSKRLAVPCKLEKMRILAHGELVLATAISSFTRHVFTCGRRGIKVWSLTGQVAEDRFPESH
LPIQTPGAFLRTCLLSSNSRSLLTGGYNLASVSVWDLAAPSLHVKEQLPCAGLNCQALDANLDANLAFASFTSGVVRIWDLRDQSVVRDL
KGYPDGVKSIVVKGYNIWTGGPDACLRCWDQRTIMKPLEYQFKSQIMSLSHSPQEDWVLLGMANGQQWLQSTSGSQRHMVGQKDSVILSV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GPR157-TLE6

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GPR157-TLE6

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for GPR157-TLE6

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source