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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GPR89A-RNF115 (FusionGDB2 ID:34475)

Fusion Gene Summary for GPR89A-RNF115

Fusion gene summary

Fusion gene information	Fusion gene name: GPR89A-RNF115
	Fusion gene ID: 34475
		Hgene	Tgene
	Gene symbol	GPR89A	RNF115
	Gene ID	653519	27246
	Gene name	G protein-coupled receptor 89A	ring finger protein 115
	Synonyms	GPHR\|GPR89\|GPR89B\|SH120\|UNQ192	BCA2\|ZNF364
	Cytomap	1q21.1	1q21.1
	Type of gene	protein-coding	protein-coding
	Description	Golgi pH regulator Aprotein GPR89putative MAPK-activating protein PM01putative NF-kappa-B-activating protein 90	E3 ubiquitin-protein ligase RNF115RING-type E3 ubiquitin transferase RNF115rabring 7zinc finger protein 364
	Modification date	20200313	20200313
	UniProtAcc	B7ZAQ6	.
	Ensembl transtripts involved in fusion gene	ENST00000454423, ENST00000534502, ENST00000313835, ENST00000462900, ENST00000478703,	ENST00000369291,
Fusion gene scores	* DoF score	3 X 2 X 3=18	11 X 8 X 6=528
	# samples	3	10
	** MAII score	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(10/528*10)=-2.40053792958373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GPR89A [Title/Abstract] AND RNF115 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GPR89A(145826888)-RNF115(145646115), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GPR89A	GO:0051452	intracellular pH reduction	18794847
Tgene	RNF115	GO:0051865	protein autoubiquitination	16288031

Fusion gene breakpoints across GPR89A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RNF115 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AR-A1AR-01A	GPR89A	chr1	145826888	-	RNF115	chr1	145646115	+
ChimerDB4	BRCA	TCGA-AR-A1AR-01A	GPR89A	chr1	145826888	+	RNF115	chr1	145646115	-

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Fusion Gene ORF analysis for GPR89A-RNF115

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000454423	ENST00000369291	GPR89A	chr1	145826888	+	RNF115	chr1	145646115	-
5UTR-3CDS	ENST00000534502	ENST00000369291	GPR89A	chr1	145826888	+	RNF115	chr1	145646115	-
In-frame	ENST00000313835	ENST00000369291	GPR89A	chr1	145826888	+	RNF115	chr1	145646115	-
intron-3CDS	ENST00000462900	ENST00000369291	GPR89A	chr1	145826888	+	RNF115	chr1	145646115	-
intron-3CDS	ENST00000478703	ENST00000369291	GPR89A	chr1	145826888	+	RNF115	chr1	145646115	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000313835

GPR89A

chr1

145826888

ENST00000369291

RNF115

chr1

145646115

8997

186

998

307

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000313835	ENST00000369291	GPR89A	chr1	145826888	+	RNF115	chr1	145646115	-	0.013818056	0.986182

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Fusion Genomic Features for GPR89A-RNF115

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
GPR89A	chr1	145826887	-	RNF115	chr1	145646114	+	0.000188265	0.9998117
GPR89A	chr1	145826887	-	RNF115	chr1	145646114	+	0.000188265	0.9998117

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GPR89A-RNF115

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:145826888/chr1:145646115)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GPR89A B7ZAQ6	.
FUNCTION: Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance (PubMed:12761501, PubMed:18794847). Plays a role in lymphocyte development, probably by acting as a RABL3 effector in hematopoietic cells (By similarity). {ECO:0000250\|UniProtKB:Q8BS95, ECO:0000269\|PubMed:12761501, ECO:0000269\|PubMed:18794847}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RNF115

chr1:145826888

chr1:145646115

ENST00000369291

228_269

305.0

Zinc finger

RING-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000313835

114_134

456.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000313835

150_170

456.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000313835

290_310

456.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000313835

343_363

456.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000313835

378_398

456.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000313835

425_445

456.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000313835

46_66

456.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000313835

5_25

456.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000313835

79_99

456.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000454423

114_134

336.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000454423

150_170

336.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000454423

290_310

336.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000454423

343_363

336.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000454423

378_398

336.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000454423

425_445

336.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000454423

46_66

336.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000454423

5_25

336.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000454423

79_99

336.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000462900

114_134

431.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000462900

150_170

431.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000462900

290_310

431.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000462900

343_363

431.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000462900

378_398

431.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000462900

425_445

431.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000462900

46_66

431.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000462900

5_25

431.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000462900

79_99

431.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000534502

114_134

431.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000534502

150_170

431.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000534502

290_310

431.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000534502

343_363

431.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000534502

378_398

431.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000534502

425_445

431.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000534502

46_66

431.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000534502

5_25

431.0

Transmembrane

Helical

Hgene

GPR89A

chr1:145826888

chr1:145646115

ENST00000534502

79_99

431.0

Transmembrane

Helical

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Fusion Gene Sequence for GPR89A-RNF115

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>34475_34475_1_GPR89A-RNF115_GPR89A_chr1_145826888_ENST00000313835_RNF115_chr1_145646115_ENST00000369291_length(transcript)=8997nt_BP=186nt
AGCTTGATGGCGTCGGGCTGGAGAGCCGCAGTCCCGGCTGCAGCACCTGGGAGAAGGCAGACCGTGTGAGGGGGCCTGTGGCCCCAGCGT
GCTGTGGCCTCGGGGAGTGGGAAGTGGAGGCAGGAGCCTTCCTTACACTTCGCCATGAGTTTCCTCATCGACTCCAGCATCATGATTACC
TCCCAGGAATATATATGTCCCAGATGTGAATCAGGCTTTATTGAAGAAGTGACAGATGATTCCAGTTTTTTAGGTGGTGGCGGCAGTCGG
ATAGACAATACCACAACAACACATTTTGCAGAGCTTTGGGGCCATTTGGATCACACGATGTTTTTTCAAGATTTTAGACCCTTTCTAAGT
AGCAGTCCACTGGACCAAGATAATAGAGCCAATGAAAGGGGTCACCAGACTCACACTGACTTCTGGGGAGCAAGACCTCCACGGTTGCCA
TTGGGTCGGAGATACAGATCTCGAGGAAGTTCTCGTCCTGACAGATCTCCAGCTATTGAAGGAATACTACAACACATCTTTGCAGGATTC
TTTGCAAATTCTGCCATTCCTGGATCTCCACACCCTTTTTCCTGGAGCGGGATGCTGCACTCCAACCCTGGGGACTATGCCTGGGGTCAG
ACAGGGCTTGATGCCATTGTAACCCAGCTTTTAGGACAACTGGAAAACACAGGCCCTCCCCCAGCTGACAAGGAAAAGATCACATCTCTT
CCAACAGTGACAGTAACTCAGGAACAAGTTGATATGGGTTTAGAGTGTCCAGTATGCAAAGAAGATTACACAGTTGAAGAGGAAGTCCGG
CAGTTACCTTGCAATCACTTCTTTCACAGCAGTTGTATTGTGCCGTGGCTAGAACTGCATGACACATGTCCTGTATGTAGGAAGAGCTTA
AATGGTGAGGACTCTACTCGGCAAAGCCAGAGCACTGAGGCCTCTGCAAGCAACAGATTTAGCAATGACAGTCAGCTACATGACCGATGG
ACTTTCTGAAGCTAAAGACCACACCTGAATCAGGGCTGTGGTAATCATCTTACCATAGCTGTAAATTGTATCAAAACAAAAAATTAGTAG
ATGGATTTAGGAATATGTAAGAAACTCAACACATAATATAAATGCAATGAATGTTTTTCTTCTTTAAATTTAAAGTTAGTATCTACAGAT
GGAATTGTATCTACAACCAAATGCCTCTTATCCCTGAATTCAGAGTGATAATTTTATAAGTGTGAAACTTAATTATGTAGGGCTCCCCCC
GTCTGAATAGAATTAATTCCTTAAAGTCTAGTTAGGGTCCTGCTGTCTGTCATGTTGCCTTGTAACGGATGTTTCCACCTCCTTCTCCAA
CCTCTACCCCACCATTAGTGTATTTTACTATAAAAACAGTGGAACCACAGCCCTAAAGTCCTGCTGATATAAAGTCCTTTTGTCTTAATT
GTATTTAAAAAAAAAAAAAAACTACTCTTGATCACATTAGCTATGAGGCGAGGTCAAATTCAGGTATCTAAGACTAATGATTTTGTTTTG
TCTTGATCCCCAGAGAGCAAATCAAAGAAAAATTACAGCAAGAAGAGAAAAGTGGTTTATCATTGTGTGCTTTGGTTTTCTTATTTTAAT
TTTTTTTGTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTCGCCTAGGCTGGAGTGCAGTGGCACGATCTTGGCTCATTGCAAACTCTGC
CTCCTGAGTTCAAGCGATTCTCCTACCTCAGCCTCCAGAGTAGCTGGGACCACAGGCATTTGTTACCATGCCCAGCTAATTTTTTGTATA
TTTAGTAGAGATGGGGTTTCACCGTGTTAGCCAGGATGGTCTCAATCTCCTGACCTTGTGCTCCGCCTGCCTCAGCCTCCCAAAGTGCTG
GGATTACAGGCGTGAGCCACTGCGCCTGGCCTCTTATTTTAATTTTTAAAGACTACTTCAGTTGATGCAGTTTCCCAAGAAACCTACATA
ACATATATTGGGAGCCTTATGTTGATAGGAATCTGATTCCCATTCCTTTTTGGGAATGAGTTGGGCAGCATACAGGCACAGAAAGACAGA
TGTTTGAGACCTTTGCTTCTGAGATTTTAAAAAATGATTACCGCTGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCG
AGGCAGGCGGATCACAAGGTCAAGAGATCAAGACCAGCCTGGCCAACAAGGTAAAACCTTGTCTCTACTAAAAATATAAAATTAGCTGGG
CCTGGTGGTGCATGCCTGTAATCCCAGCTACTCATGAGGCTGAGGTGGGAGAATCGCTTGAACCCAGGAGGTGGAGGTTGCGGTGAGCCG
GATCATACCAATGCACTCCAGTCTGGGCAACAAGAGCGAAACTCCATCTCAAAAAAAAAAAAAAAATCCCCAACTCACTGCTTTTTTTGT
TTGTTTCTGTCGCCTAGGCTGGAGTGCAGTGGCACGATCTCAGCTCACCACAGCCTCGACCTCCCAGGCTCAAGTGATCCTCCCACCTCA
GCCTACCAAGTGGCTGGGACTACAGGCGTGTGCCACCATGCCTGGGTAATTTTTGTATTTTTGTAGAGATAGGGTTTTGCCGTGTTGCCC
AGGCTGGTCTCAAACTCCTGGGCTCAAGTGATCTGCCTGCCTCAACCTCTCAAAGTGCTCAACTCATTGTTTACTGTCTTTTTTCCTAGT
AATCTTAAAATAATTTGCCTCACAGAAATAGAGACAGTAAGTGTCTGCAGCCAGTTCACTGTTTTTGGTAATTCATTGGTCTTCAGGAGT
TAAGATTTTACATTGTCACATTTTAATTTTTAAGCCTATTTTTCATCTCTGAAACTTTCCTTTTCTCCTTGGTTCTGGCTATACTTGGAC
TCAAACTGATCAGTGTGATCATGTCCAAAACAGCTTGGCCTGGAAGAGGTAGGCCTTATTTTTTCAGCCTAGTAGTGTCCCATGCACATG
CTCTTTGTAGCATTCAAGTGTTTAACATTGGATAAATTAAGAAGGTCAAGAATGTTGTTGAAACTTCAAGGTCTCAAAAGGAAATGATGG
GGACATAGAACAACTGTTGGTGTACCAAAAAAAGGTACAGAGGGGCACCATTTGTATTGTCACACAACAATGATCAGAATGATCAGTTTA
GAATGATCAGAACAAAAACACCACTCTTTAATGGGTCTTTTTCTTGGCTAGAAGTCTTTCCTCAGTTTTTGTTGACTATCATACGCTGAT
TTGTGGGTGACGGAAGGGGGCTAGAGATAACGTTTCTCTGTACTTTGGTAAAGGATGAAGGAGTCAGAGAGGGAACAGAAAAAGTGAGAG
AGTGGCCTGCTGAAATAATAGCCTGCCTCTAAAAGTTGTGACCAGAAAGTATGATTCATTTGGGCCCAGAGGGAATAAAATATGTTTTTT
CATATACCTCCCATATTACACCTCTGTAGTGATTGTTTATTTGGGGAATGAGATCTACTTACTGTGCGTTGCCCCTGAAATGTAGCTTGA
GAATACACACTGGTTTTGAATTGGGGAGGAGGATGGAAGGAAATTAGAGGTGTATTATGAATATTTGGCCACTACTTAGATGGAGGAAGG
CTATGTTGAACTTGGGACACATTGCAGTTTTCAAGTACACAATATCAGTTGTCTCAGAAAAATCATGACAGCCTGGACATATTTGCTTGT
CAGTGTCTGGAGATGCCAGGACAGGCAGTTGTAGTTTTACGTACAGATAGAGAACCAATGCCTAGAGAACTAGAAAGGATCTGAGTAGCT
TTAAAAAGGGTGGAAACAAAGTACTGGATAGGGGTCTGCCTTTTTATACACAGTATAGCAAACAGCATCAGACAAAGTTACATGAAGTTT
TCTTCACTTTTTTTGCTCTGATGGATAGAGGATGTGAGACTCATTTTACTGTTTCCCAGACCTGTCCCACTTAATGGATCTGTTGTGTTT
CTTCTTATAATGGCAGGCACCTCAGATGTCCAGGTTAATTTATGTTGAGGAGTTAGGATTCTTCAGGGATTTATTATTATTATTATTATT
ATTTATTTATTTATTTATTTATTTATTTATTTTTTGAGATGGAGGCTTGCTCTGTCGCCTAGGCTGGAGTGCAGTGGCGCAATCTCAGCT
CACTGCAACCTCCACCTCCTGGGTTCCAGCGATTCTTCTGCCTTAGCCTCCCAAGCAGCTGGGATTACAGGCACCTGCCACCATGCCCAG
CTAATTTTTTATATGTTTAGTAGAGACAAGGTTTTACCTTGTTGGCCAGGCTGGTCTTGAACTCTAGACCTCAGGTGATCTGCCAGTCGT
GGCCTCCCAAAGTGCTGGGATTACAGACGGGAGCCACCATGCCCAGCCTGAGATTTATTATAAGGAATTGGTTCACACAATAATGGAGTT
TGAGAAATCCCAAGATCTGCAGTGGGCCAGCTAGAGATCCAGGAGAGCTGATGGTGTAGTTCCAGTCTGAAGGCCAGCTTGGATACCCTA
GAAGAGCTGATGTTTCTGTTCCAGTTCAGAGGCAGGAAAAGACTGAGGTCTTAGTTCAAGCAGTCAGGCAGGAGGACTTCTCCCTTACTT
GTTCTATTCAGACCTTCAACTGATTGGATGAGGGCCACTTACATTAGGGAGGGCCATGTGCTGTATTCAGTCTACTGACTGAAATGTTAG
TCTCTTCCAAAAACACCCTCACAGACACACCCAGAATACTGTATGACCAAATATCTGGGCATCATGTGGCCTAGTCAAGTTGACACATAA
GATTAACCATCACAATGAGGAAAAACAGAAATGATACATGTATACAGAGTGCTCCTCATCCCAATTAAGTTTCACCAAGTTAATAATGTG
TCTCTATGAGAAGTGGTTCACCATGTTGGTCAGGCTGTTTTCAAACTCCTGACCTCAGGTGACCACCCGCCTCGGCCTCCCAAAGTGCTG
GGATTACAGGTGTGAGCTAGCACTCCCAGCCGACAGGTGCTTCTTAAATGTTTTCTTTGAGCAGGAATTGGTCCAGGAATTGGTTCTCAA
GTTAGAAGGAAAATTTGAGGGGAAGAACTTGTTTTTTCTCCAATCAGTCTCTGATTAAATAGTTATTAGGAAAAACTCCTTGCTTATGTC
TTTGTATTGCACATTTTTATATATGTATATATGTGTAAATAGAGATATTTATATATTCACAGACAAACACGTGTATGCACATTTCACAAT
GGAGGAAGAAGGGATATGGTGTGCACTGAGGTAAAGTGAGCAGGGATACAGAAGAGAGCTGGAGCCTCACAGTCTGATTCTCTCATTGTA
CATAACCTTTAGGGTCTTTGTTTCCCTGAGTTCTCTGGTATGGGGCACTGTTGGCTTGGGCTGGTACCCTGTTATTCTCTGTGATGAAGG
GATTCACTGGAGGTAAAAACGTAATCATTTCCAAAGGTTGAGAATAAATGACTTTGAGGAAAGGGTGTTCATTATCCGTTGCTTCTATAT
TATAATCAGTTGAACTACAATACGGTTATCTATTGATTTTTTTTAATTTTTCTGACAAATTATTGACACCAAATTGAATAATTCATGACC
TGCATGCTTCAGCTTCTTTCTCCCTGGTTTCCAGGTGCTATTCCCTCAAGAAATGCAAATTAAATATGTCGGTCTTAATAAATCAGGAGG
GAAGCATAGTCTGTGTCTGTTTTAAATGACAACAACAACAAAACAGCTTTGGGGTTTAAGAAGTGGAAGACACATTTTTATTTTTTTGAG
ACACAATCTCACTCTTTCGCCCAGGCTGGAGTGCAGTGGCGTGATCTCAGGTCACTGCAACCTCCCGCTCCTGGGTTCAAGCGATTCTCT
TGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACGTGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTTGCCA
TGTTGCCCAGGCTGGTCTCGAACTCCTGATGTCAAGTGATCACCGACCTCAGCATCCCAAAGTGCTGGGATTACAGGCATTAGCCACCAC
GCCCAGGTGAGAAGACAGATTTTAAGAGAAGGAGCAGGGCTGGTATCTGAATAGGTATTTGGATGTTAGGGGAAAACCCTTTTTGGCCTC
TGTGGTAGAGCGATCGGAAGGTAAAAGTGCTGTTTACAAGAATAATCCATTGGAGATCTGGGGATTGGGGACGACTTATAGGATAGAGTC
CTCTTGTTGAGAATTTCCCGAATGAATCTCATGTAGGTTCTGTCACAGTAAGATGGAGGAAAACTTTGATGGGGTAAGTATCACAAGTGG
CTGTCCTATAGGGGGAAATCCTAGCCTGCAGTAATGTCAGTGTCTCAGTATTCAGCCAGCGAGCCACTGAGCTGCTCCAGGGGTTTAAAA
TAGAATGCATAGAATACAATGTATACAGCTGGTGATGCTTTCCAGGATCAAAATAGAGCCCTTGTCTGATCCCATTGACATTGTAAGGTT
TCGATCTCTCATACCTGCCACAGACAAGTACATTGTAGGCATTCAACTTTTAAGGTTTTATACATGCAAACTTTATGTTTTCCTGCCACA
CTACACTTGGTGTCCACAGAAGTGTAGTTTGTATGTTGCCTCTTCTTCCTCTTTCAACCAGAACACTTAGATCTGTGATCATAGGATGTA
AGCCTGTGATTCTTTACTTTTTCTAATAAGAAATACAATTTTCAAGATCCAAAAATTATTAGATTCTTGGCTGGGCATTGTGGCTCATGC
CTGTAATCTCAGCATTTTGGAAGGCTGAGGCAGGCAGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGGCAGCACAATAAAACACCA
TGTCTACTAAAAATACAAAAATTAGCCAGGTGTGGTGGCATGCACCTGTAGTCCCAGCTACTTGGGAGGCTGAGGAGGGAGAATCGTTTG
AACCAAGGAGGCAGAGGTTGTAGTGAGCCAAGATTGTGCCACTGCACTCCAGGGCAACAGAGAGAGACCCTGTCTCAAAACAAAAACCCC
CAAATTATTAGATTCCCTTCCAACAACTTGATAGCCATATTATTAGTATTTTTGATTAAAGAATACATAACAAAAAGCTGCTATGATTTC
AGTAATGCTTTTAAGTTAATTTATTAGTCACACCAGAATCTACATCCAATTGAAATATATACAAATATTTGAAAGATATTTATTCAGGCT
GAAGATTATGGTATATAGATTCCTTCTGATAACCTCATGGCCTCACAGGTTCAAAACCCGTGTTTGTGAATCACTCATACAGATTGGGGC
TAAGATGCGTGTCCAGAAAACCACCTATTATGCATGAAAATTTGTAGGCTTATTTGAAGGCAATTGTATCAACACATTTTGAAAGCCAAG
ACACAAGTATTTTAAGTTTCTGTTTAACCAAGTCTCGAGATAAGCAGAGTAAATAAACTCTTTAGAAGCAAGACTCAGTTGGTATGTACA
AAGTGGGATTGCTTTGTATATATTCCGCTTAGTTTGAGTCAGAGCTAGTAATCTGATGCTCTTAAATGTCTTCATAAACTTGGGCAGTGA
TGTTTCCTTTCTGTGATTATGTGTCACAGATTTTTATATGTGGACTATAATTAGTATAGTACAATGGCTGAAACTTTTCCTATAGTTGGA
TATATCTTCTGAGACTTCCAGTGATTGTATAATGTTGAGTAGCTCCAGAAGATTATTTGAATAGTAAAAACAAAAGACATCTCTACCTAT
GTGAGTTTATTATTTAGTTAGAAACACAGAACTAACTATTTAAAACAGGTAGAGAAAGATTAAGATGAATGTGATGTAGTGGAGAAAGCT
TTGGAGACTTTGGAGTCAGAACTCAAATGGCTCTAGGTCCCAAATCCAGACTCTCATTTTGATTCTCAGAACAATTCTGTGGAAAGAGAA
GATACAATAGGCAATATCCCTTTTTACAGATAGGTAAACAGAAATAGCATCTCAAAACCTCATTTGCACTGGGTGAGGTGGCTCACGCCT
GTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCGTC
TCTACCAAAAACACAAAAATTAGCCAGGCATGGTGGTGCATGCCTGTAATCCCAGCTACTTGGGAGACTGAGGCAGGAGAATTGCTTGAA
CCCGGGAGGTGGAGGTTGCAGTGAGCTGAGATCATGCCACTGCACTCCAGCCTGGGCAACAGAGTGAGACTCCGTCTCAAAAAAAAAAAA
AAAAATTCATTTGCCCAATGACAAATAGCTGGTATGTTGCAGAGCCAGAATTTGAATCCAGGTCTTTTTGCCTCCATGGCTAGTCCTTTT
ATCTCCATGGGATACAGTCTAAAATCCTTAGTTTGAGGTTCAAGACTATCACTAATAAGAGTCTTACTCATCTACTTCAGCCATATCTCT
TTCCGTTCCCACAAACCTTAGCTCCCACATTTGGCAGGTCCTTGCCAAGGAGCACAGGTAAAGTGTCTCTTTCCTTTTAATGGCTCACCA
TGGAGCTGTAGCTAAATTTCTGTGCTCTTACCCCTTTATTCATGTAGTTCCTCCTATCAGGAATATCCTGCCCACTCTCTGCTTAACTAT
GACAAGAGGTCATCTGTCCAAAGAGAAAGAAGAGAGTTTGTGGATTTAGGAGAAAAGAAAATACTCCAAATACTGCTATGGGCATTTATT
TAAAAAGAGAAATGACCAAAGAGGTTAACAAGTATTTAGATGAAGCTGGGCAGTTGTAGTCTGTGGTGCTCTTGGTCTGCACAAATCTTC
CTCTTCCTCCAGCAGTGCTGTATGGATGTTGTTGAATGTTGAGGTCTGTCTGCATTTTCTCATTTTCATGCCAAGTCAATCACTGGATCT

>34475_34475_1_GPR89A-RNF115_GPR89A_chr1_145826888_ENST00000313835_RNF115_chr1_145646115_ENST00000369291_length(amino acids)=307AA_BP=37
MWPQRAVASGSGKWRQEPSLHFAMSFLIDSSIMITSQEYICPRCESGFIEEVTDDSSFLGGGGSRIDNTTTTHFAELWGHLDHTMFFQDF
RPFLSSSPLDQDNRANERGHQTHTDFWGARPPRLPLGRRYRSRGSSRPDRSPAIEGILQHIFAGFFANSAIPGSPHPFSWSGMLHSNPGD
YAWGQTGLDAIVTQLLGQLENTGPPPADKEKITSLPTVTVTQEQVDMGLECPVCKEDYTVEEEVRQLPCNHFFHSSCIVPWLELHDTCPV

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Fusion Gene PPI Analysis for GPR89A-RNF115

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GPR89A-RNF115

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for GPR89A-RNF115

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source