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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GPR89B-CAPN2 (FusionGDB2 ID:34476)

Fusion Gene Summary for GPR89B-CAPN2

check button Fusion gene summary
Fusion gene informationFusion gene name: GPR89B-CAPN2
Fusion gene ID: 34476
HgeneTgene
Gene symbol

GPR89B

CAPN2

Gene ID

653519

824

Gene nameG protein-coupled receptor 89Acalpain 2
SynonymsGPHR|GPR89|GPR89B|SH120|UNQ192CANP2|CANPL2|CANPml|mCANP
Cytomap

1q21.1

1q41

Type of geneprotein-codingprotein-coding
DescriptionGolgi pH regulator Aprotein GPR89putative MAPK-activating protein PM01putative NF-kappa-B-activating protein 90calpain-2 catalytic subunitCANP 2M-calpaincalcium-activated neutral proteinase 2calpain 2, (m/II) large subunitcalpain 2, large [catalytic] subunitcalpain 2, large subunitcalpain M-typecalpain, large polypeptide L2millimolar-calpain
Modification date2020031320200313
UniProtAcc

P0CG08

P17655

Ensembl transtripts involved in fusion geneENST00000488603, ENST00000314163, 
ENST00000295006, ENST00000433674, 
ENST00000474026, 
Fusion gene scores* DoF score6 X 3 X 4=7211 X 7 X 7=539
# samples 611
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/539*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GPR89B [Title/Abstract] AND CAPN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGPR89B(147460753)-CAPN2(223946971), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGPR89B

GO:0051452

intracellular pH reduction

18794847

TgeneCAPN2

GO:0051603

proteolysis involved in cellular protein catabolic process

12150984


check buttonFusion gene breakpoints across GPR89B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CAPN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer61NGPR89Bchr1

147460753

+CAPN2chr1

223946971

+


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Fusion Gene ORF analysis for GPR89B-CAPN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000488603ENST00000295006GPR89Bchr1

147460753

+CAPN2chr1

223946971

+
3UTR-3CDSENST00000488603ENST00000433674GPR89Bchr1

147460753

+CAPN2chr1

223946971

+
3UTR-3UTRENST00000488603ENST00000474026GPR89Bchr1

147460753

+CAPN2chr1

223946971

+
5CDS-3UTRENST00000314163ENST00000474026GPR89Bchr1

147460753

+CAPN2chr1

223946971

+
In-frameENST00000314163ENST00000295006GPR89Bchr1

147460753

+CAPN2chr1

223946971

+
In-frameENST00000314163ENST00000433674GPR89Bchr1

147460753

+CAPN2chr1

223946971

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000314163GPR89Bchr1147460753+ENST00000433674CAPN2chr1223946971+31841239752024649
ENST00000314163GPR89Bchr1147460753+ENST00000295006CAPN2chr1223946971+31861239752024649

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000314163ENST00000433674GPR89Bchr1147460753+CAPN2chr1223946971+0.001897420.9981026
ENST00000314163ENST00000295006GPR89Bchr1147460753+CAPN2chr1223946971+0.0018978450.9981021

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Fusion Genomic Features for GPR89B-CAPN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GPR89Bchr1147460753+CAPN2chr1223946971+4.05E-101
GPR89Bchr1147460753+CAPN2chr1223946971+4.05E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GPR89B-CAPN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:147460753/chr1:223946971)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPR89B

P0CG08

CAPN2

P17655

FUNCTION: Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance (PubMed:18794847). Plays a role in lymphocyte development, probably by acting as a RABL3 effector in hematopoietic cells (By similarity). {ECO:0000250|UniProtKB:Q8BS95, ECO:0000269|PubMed:18794847}.FUNCTION: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity). {ECO:0000250|UniProtKB:O08529, ECO:0000269|PubMed:17650508}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGPR89Bchr1:147460753chr1:223946971ENST00000314163+1214114_134365456.0TransmembraneHelical
HgeneGPR89Bchr1:147460753chr1:223946971ENST00000314163+1214150_170365456.0TransmembraneHelical
HgeneGPR89Bchr1:147460753chr1:223946971ENST00000314163+1214290_310365456.0TransmembraneHelical
HgeneGPR89Bchr1:147460753chr1:223946971ENST00000314163+1214343_363365456.0TransmembraneHelical
HgeneGPR89Bchr1:147460753chr1:223946971ENST00000314163+121446_66365456.0TransmembraneHelical
HgeneGPR89Bchr1:147460753chr1:223946971ENST00000314163+12145_25365456.0TransmembraneHelical
HgeneGPR89Bchr1:147460753chr1:223946971ENST00000314163+121479_99365456.0TransmembraneHelical
TgeneCAPN2chr1:147460753chr1:223946971ENST000002950061021585_596439701.0Calcium bindingNote=1
TgeneCAPN2chr1:147460753chr1:223946971ENST000002950061021615_626439701.0Calcium bindingNote=2
TgeneCAPN2chr1:147460753chr1:223946971ENST000004336741021585_596361623.0Calcium bindingNote=1
TgeneCAPN2chr1:147460753chr1:223946971ENST000004336741021615_626361623.0Calcium bindingNote=2
TgeneCAPN2chr1:147460753chr1:223946971ENST000002950061021572_605439701.0DomainEF-hand 1
TgeneCAPN2chr1:147460753chr1:223946971ENST000002950061021602_637439701.0DomainEF-hand 2
TgeneCAPN2chr1:147460753chr1:223946971ENST000002950061021667_700439701.0DomainEF-hand 3
TgeneCAPN2chr1:147460753chr1:223946971ENST000004336741021572_605361623.0DomainEF-hand 1
TgeneCAPN2chr1:147460753chr1:223946971ENST000004336741021602_637361623.0DomainEF-hand 2
TgeneCAPN2chr1:147460753chr1:223946971ENST000004336741021667_700361623.0DomainEF-hand 3
TgeneCAPN2chr1:147460753chr1:223946971ENST000002950061021515_529439701.0RegionNote=Linker
TgeneCAPN2chr1:147460753chr1:223946971ENST000002950061021530_700439701.0RegionNote=Domain IV
TgeneCAPN2chr1:147460753chr1:223946971ENST000004336741021515_529361623.0RegionNote=Linker
TgeneCAPN2chr1:147460753chr1:223946971ENST000004336741021530_700361623.0RegionNote=Domain IV

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGPR89Bchr1:147460753chr1:223946971ENST00000314163+1214378_398365456.0TransmembraneHelical
HgeneGPR89Bchr1:147460753chr1:223946971ENST00000314163+1214425_445365456.0TransmembraneHelical
TgeneCAPN2chr1:147460753chr1:223946971ENST00000295006102145_344439701.0DomainCalpain catalytic
TgeneCAPN2chr1:147460753chr1:223946971ENST00000433674102145_344361623.0DomainCalpain catalytic
TgeneCAPN2chr1:147460753chr1:223946971ENST000002950061021345_514439701.0RegionNote=Domain III
TgeneCAPN2chr1:147460753chr1:223946971ENST000004336741021345_514361623.0RegionNote=Domain III


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Fusion Gene Sequence for GPR89B-CAPN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>34476_34476_1_GPR89B-CAPN2_GPR89B_chr1_147460753_ENST00000314163_CAPN2_chr1_223946971_ENST00000295006_length(transcript)=3186nt_BP=1239nt
AGCTTGACGGCGTCGGGCTGGAGAGCCGCAGTCCCGGCTGCAGCACCTGGGAGAAGGCAGACCGTGTGAGGGGGCCTGTGGCCCCAGCGT
GCTGTGGCCTCCGGGAGTGGGAAGTGGAGGCAGGAGCCTTCCTTACACTTCGCCATGAGTTTCCTGATCGACTCCAGCATCATGATTACC
TCCCAGATACTATTTTTTGGATTTGGGTGGCTTTTCTTCATGCGCCAATTGTTTAAAGACTATGAGATACGTCAGTATGTTGTACAGGTG
ATCTTCTCCGTGACGTTTGCATTTTCTTGCACCATGTTTGAGCTCATCATCTTTGAAATCTTAGGAGTATTGAATAGCAGCTCCCGTTAT
TTTCACTGGAAAATGAACCTGTGTGTAATTCTGCTGATCCTGGTTTTCATGGTGCCTTTTTACATTGGCTATTTTATTGTGAGCAATATC
CGACTACTGCATAAACAACGACTGCTTTTTTCCTGTCTCTTATGGCTGACCTTTATGTATTTCTTCTGGAAACTAGGAGATCCCTTTCCC
ATTCTCAGCCCAAAACATGGGATCTTATCCATAGAACAGCTCATCAGCCGGGTTGGTGTGATTGGAGTGACTCTCATGGCTCTTCTTTCT
GGATTTGGTGCTGTCAACTGCCCATACACTTACATGTCTTACTTCCTCAGGAATGTGACTGACACGGATATTCTAGCCCTGGAACGGCGA
CTGCTGCAAACCATGGATATGATCATAAGCAAAAAGAAAAGGATGGCAATGGCACGGAGAACAATGTTCCAGAAGGGGGAAGTGCATAAC
AAACCATCAGGTTTCTGGGGAATGATAAAAAGTGTTACCACTTCAGCATCAGGAAGTGAAAATCTTACTCTTATTCAACAGGAAGTGGAT
GCTTTGGAAGAATTAAGCAGGCAGCTTTTTCTGGAAACAGCTGATCTATATGCTACCAAGGAGAGAATAGAATACTCCAAAACCTTCAAG
GGGAAATATTTTAATTTTCTTGGTTACTTTTTCTCTATTTACTGTGTTTGGAAAATTTTCATGGCTACCATCAATATTGTTTTTGATCGA
GTTGGGAAAACGGATCCTGTCACAAGAGGCATTGAGATCACTGTGAATTATCTGGGAATCCAATTTGATGTGAAGTTTTGGTCCCAACAC
ATTTCCTTCATTCTTGTTGGAATAATCATCGTCACATCCATCAGAGGATTGCTGATCACTCTTACCAAGTTAAGTGGGCAGACCAACATC
CACCTCAGCAAAAACTTCTTCCTGACGAATCGCGCCAGGGAGCGCTCAGACACCTTCATCAACCTCCGGGAGGTGCTCAACCGCTTCAAG
CTGCCGCCAGGAGAGTACATTCTCGTGCCTTCCACCTTCGAACCCAACAAGGATGGGGATTTCTGCATCCGGGTCTTTTCTGAAAAGAAA
GCTGACTACCAAGCTGTCGATGATGAAATCGAGGCCAATCTTGAAGAGTTCGACATCAGCGAGGATGACATTGATGATGGATTCAGGAGA
CTGTTTGCCCAGTTGGCAGGAGAGGATGCGGAGATCTCTGCCTTTGAGCTGCAGACCATCCTGAGAAGGGTTCTAGCAAAGCGCCAAGAT
ATCAAGTCAGATGGCTTCAGCATCGAGACATGCAAAATTATGGTTGACATGCTAGATTCGGACGGGAGTGGCAAGCTGGGGCTGAAGGAG
TTCTACATTCTCTGGACGAAGATTCAAAAATACCAAAAAATTTACCGAGAAATCGACGTTGACAGGTCTGGTACCATGAATTCCTATGAA
ATGCGGAAGGCATTAGAAGAAGCAGGTTTCAAGATGCCCTGTCAACTCCACCAAGTCATCGTTGCTCGGTTTGCAGATGACCAGCTCATC
ATCGATTTTGATAATTTTGTTCGGTGTTTGGTTCGGCTGGAAACGCTATTCAAGATATTTAAGCAGCTGGATCCCGAGAATACTGGAACA
ATAGAGCTCGACCTTATCTCTTGGCTCTGTTTCTCAGTACTTTGAAGTTATAACTAATCTGCCTGAAGACTTCTCATGATGGAAAATCAG
CCAAGGACTAAGCTTCCATAGAAATACACTTTGTATCTGGACCTCAAAATTATGGGAACATTTACTTAAACGGATGATCATAGCTGAAAA
TAATGATACTGTCAATTTGAGATAGCAGAAGTTTCACACATCAAAGTAAAAGATTTGCATATCATTATACTAAATGCAAATGAGTCGCTT
AACCCTTGACAAGGTCAAAGAAAGCTTTAAATCTGTAAATAGTATACACTTTTTACTTTTACACACTTTCCTGTTCATAGCAATATTAAA
TCAGGAAAAAAAAATGCAGGGAGGTATTTAACAGCTGAGCAAAAACATTGAGTCGCTCTCAAAGGACACGAGGCCCTTGGCAGGGAATAT
TTAAAGCAACTTCAAGTTTAAAATGCAGCTGTTGATTCTACCAAACAACAGTCCAAGATTACCATTTCCCATGAGCCAACTGGGAAACAT
GGTATATCATGAAGTAATCTTGTCAAGGCATCTGGAGAGTCCAGGAGAGAAGACTCACCTCTGTCGCTTGGGTTAAACAAGAGACAGGTT
TTGTAGAATATTGATTGGTAATAGTAAATCGTTCTCCTTACAATCAAGTTCTTGACCCTATTCGGCCTTATACATCTGGTCTTACAAAGA
CCAAAGGGATCCTGCGCTTGATCAACTGAACCAGTATGCCAAAACCAGGCATCCAATTTGTAAACCAATTATGATAAAGGACAAAATAAG
CTGTTTGCCACCTCAAAACTTTATGAACTTCACCACCACTAGTGTCTGTCCATGGAGTTAGAGGGGACATCACTTAGAAGTTCTTATAGA
AAGGACACAAGTTTGTTTCCTGGCTTTACCTTGGGAAAATGCTAGCAACATTATAGAAATTTTGCCTTGTTGCCTTATCTTCTTCCAAAT
GTACTGTTAAATAAAAATAAAGGGTTACCCCATGCAATCACACCATGCCATGTTTTCCTTCCTGGAGGGCAGCCCCACAGGACGGTTTAT
GAGCACACAATTATAGCTTGTTTCTACTTTAACAAGGTATGCTGCCTCTGTAAATTCATGTATTCAAAGGAAAAGACACCTTGCCTATAA

>34476_34476_1_GPR89B-CAPN2_GPR89B_chr1_147460753_ENST00000314163_CAPN2_chr1_223946971_ENST00000295006_length(amino acids)=649AA_BP=388
MWPQRAVASGSGKWRQEPSLHFAMSFLIDSSIMITSQILFFGFGWLFFMRQLFKDYEIRQYVVQVIFSVTFAFSCTMFELIIFEILGVLN
SSSRYFHWKMNLCVILLILVFMVPFYIGYFIVSNIRLLHKQRLLFSCLLWLTFMYFFWKLGDPFPILSPKHGILSIEQLISRVGVIGVTL
MALLSGFGAVNCPYTYMSYFLRNVTDTDILALERRLLQTMDMIISKKKRMAMARRTMFQKGEVHNKPSGFWGMIKSVTTSASGSENLTLI
QQEVDALEELSRQLFLETADLYATKERIEYSKTFKGKYFNFLGYFFSIYCVWKIFMATINIVFDRVGKTDPVTRGIEITVNYLGIQFDVK
FWSQHISFILVGIIIVTSIRGLLITLTKLSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRV
FSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGK
LGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDP

--------------------------------------------------------------
>34476_34476_2_GPR89B-CAPN2_GPR89B_chr1_147460753_ENST00000314163_CAPN2_chr1_223946971_ENST00000433674_length(transcript)=3184nt_BP=1239nt
AGCTTGACGGCGTCGGGCTGGAGAGCCGCAGTCCCGGCTGCAGCACCTGGGAGAAGGCAGACCGTGTGAGGGGGCCTGTGGCCCCAGCGT
GCTGTGGCCTCCGGGAGTGGGAAGTGGAGGCAGGAGCCTTCCTTACACTTCGCCATGAGTTTCCTGATCGACTCCAGCATCATGATTACC
TCCCAGATACTATTTTTTGGATTTGGGTGGCTTTTCTTCATGCGCCAATTGTTTAAAGACTATGAGATACGTCAGTATGTTGTACAGGTG
ATCTTCTCCGTGACGTTTGCATTTTCTTGCACCATGTTTGAGCTCATCATCTTTGAAATCTTAGGAGTATTGAATAGCAGCTCCCGTTAT
TTTCACTGGAAAATGAACCTGTGTGTAATTCTGCTGATCCTGGTTTTCATGGTGCCTTTTTACATTGGCTATTTTATTGTGAGCAATATC
CGACTACTGCATAAACAACGACTGCTTTTTTCCTGTCTCTTATGGCTGACCTTTATGTATTTCTTCTGGAAACTAGGAGATCCCTTTCCC
ATTCTCAGCCCAAAACATGGGATCTTATCCATAGAACAGCTCATCAGCCGGGTTGGTGTGATTGGAGTGACTCTCATGGCTCTTCTTTCT
GGATTTGGTGCTGTCAACTGCCCATACACTTACATGTCTTACTTCCTCAGGAATGTGACTGACACGGATATTCTAGCCCTGGAACGGCGA
CTGCTGCAAACCATGGATATGATCATAAGCAAAAAGAAAAGGATGGCAATGGCACGGAGAACAATGTTCCAGAAGGGGGAAGTGCATAAC
AAACCATCAGGTTTCTGGGGAATGATAAAAAGTGTTACCACTTCAGCATCAGGAAGTGAAAATCTTACTCTTATTCAACAGGAAGTGGAT
GCTTTGGAAGAATTAAGCAGGCAGCTTTTTCTGGAAACAGCTGATCTATATGCTACCAAGGAGAGAATAGAATACTCCAAAACCTTCAAG
GGGAAATATTTTAATTTTCTTGGTTACTTTTTCTCTATTTACTGTGTTTGGAAAATTTTCATGGCTACCATCAATATTGTTTTTGATCGA
GTTGGGAAAACGGATCCTGTCACAAGAGGCATTGAGATCACTGTGAATTATCTGGGAATCCAATTTGATGTGAAGTTTTGGTCCCAACAC
ATTTCCTTCATTCTTGTTGGAATAATCATCGTCACATCCATCAGAGGATTGCTGATCACTCTTACCAAGTTAAGTGGGCAGACCAACATC
CACCTCAGCAAAAACTTCTTCCTGACGAATCGCGCCAGGGAGCGCTCAGACACCTTCATCAACCTCCGGGAGGTGCTCAACCGCTTCAAG
CTGCCGCCAGGAGAGTACATTCTCGTGCCTTCCACCTTCGAACCCAACAAGGATGGGGATTTCTGCATCCGGGTCTTTTCTGAAAAGAAA
GCTGACTACCAAGCTGTCGATGATGAAATCGAGGCCAATCTTGAAGAGTTCGACATCAGCGAGGATGACATTGATGATGGATTCAGGAGA
CTGTTTGCCCAGTTGGCAGGAGAGGATGCGGAGATCTCTGCCTTTGAGCTGCAGACCATCCTGAGAAGGGTTCTAGCAAAGCGCCAAGAT
ATCAAGTCAGATGGCTTCAGCATCGAGACATGCAAAATTATGGTTGACATGCTAGATTCGGACGGGAGTGGCAAGCTGGGGCTGAAGGAG
TTCTACATTCTCTGGACGAAGATTCAAAAATACCAAAAAATTTACCGAGAAATCGACGTTGACAGGTCTGGTACCATGAATTCCTATGAA
ATGCGGAAGGCATTAGAAGAAGCAGGTTTCAAGATGCCCTGTCAACTCCACCAAGTCATCGTTGCTCGGTTTGCAGATGACCAGCTCATC
ATCGATTTTGATAATTTTGTTCGGTGTTTGGTTCGGCTGGAAACGCTATTCAAGATATTTAAGCAGCTGGATCCCGAGAATACTGGAACA
ATAGAGCTCGACCTTATCTCTTGGCTCTGTTTCTCAGTACTTTGAAGTTATAACTAATCTGCCTGAAGACTTCTCATGATGGAAAATCAG
CCAAGGACTAAGCTTCCATAGAAATACACTTTGTATCTGGACCTCAAAATTATGGGAACATTTACTTAAACGGATGATCATAGCTGAAAA
TAATGATACTGTCAATTTGAGATAGCAGAAGTTTCACACATCAAAGTAAAAGATTTGCATATCATTATACTAAATGCAAATGAGTCGCTT
AACCCTTGACAAGGTCAAAGAAAGCTTTAAATCTGTAAATAGTATACACTTTTTACTTTTACACACTTTCCTGTTCATAGCAATATTAAA
TCAGGAAAAAAAAATGCAGGGAGGTATTTAACAGCTGAGCAAAAACATTGAGTCGCTCTCAAAGGACACGAGGCCCTTGGCAGGGAATAT
TTAAAGCAACTTCAAGTTTAAAATGCAGCTGTTGATTCTACCAAACAACAGTCCAAGATTACCATTTCCCATGAGCCAACTGGGAAACAT
GGTATATCATGAAGTAATCTTGTCAAGGCATCTGGAGAGTCCAGGAGAGAAGACTCACCTCTGTCGCTTGGGTTAAACAAGAGACAGGTT
TTGTAGAATATTGATTGGTAATAGTAAATCGTTCTCCTTACAATCAAGTTCTTGACCCTATTCGGCCTTATACATCTGGTCTTACAAAGA
CCAAAGGGATCCTGCGCTTGATCAACTGAACCAGTATGCCAAAACCAGGCATCCAATTTGTAAACCAATTATGATAAAGGACAAAATAAG
CTGTTTGCCACCTCAAAACTTTATGAACTTCACCACCACTAGTGTCTGTCCATGGAGTTAGAGGGGACATCACTTAGAAGTTCTTATAGA
AAGGACACAAGTTTGTTTCCTGGCTTTACCTTGGGAAAATGCTAGCAACATTATAGAAATTTTGCCTTGTTGCCTTATCTTCTTCCAAAT
GTACTGTTAAATAAAAATAAAGGGTTACCCCATGCAATCACACCATGCCATGTTTTCCTTCCTGGAGGGCAGCCCCACAGGACGGTTTAT
GAGCACACAATTATAGCTTGTTTCTACTTTAACAAGGTATGCTGCCTCTGTAAATTCATGTATTCAAAGGAAAAGACACCTTGCCTATAA

>34476_34476_2_GPR89B-CAPN2_GPR89B_chr1_147460753_ENST00000314163_CAPN2_chr1_223946971_ENST00000433674_length(amino acids)=649AA_BP=388
MWPQRAVASGSGKWRQEPSLHFAMSFLIDSSIMITSQILFFGFGWLFFMRQLFKDYEIRQYVVQVIFSVTFAFSCTMFELIIFEILGVLN
SSSRYFHWKMNLCVILLILVFMVPFYIGYFIVSNIRLLHKQRLLFSCLLWLTFMYFFWKLGDPFPILSPKHGILSIEQLISRVGVIGVTL
MALLSGFGAVNCPYTYMSYFLRNVTDTDILALERRLLQTMDMIISKKKRMAMARRTMFQKGEVHNKPSGFWGMIKSVTTSASGSENLTLI
QQEVDALEELSRQLFLETADLYATKERIEYSKTFKGKYFNFLGYFFSIYCVWKIFMATINIVFDRVGKTDPVTRGIEITVNYLGIQFDVK
FWSQHISFILVGIIIVTSIRGLLITLTKLSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRV
FSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGK
LGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDP

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Fusion Gene PPI Analysis for GPR89B-CAPN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GPR89B-CAPN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GPR89B-CAPN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource