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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AKR1C3-AKR1E2 (FusionGDB2 ID:3448)

Fusion Gene Summary for AKR1C3-AKR1E2

check button Fusion gene summary
Fusion gene informationFusion gene name: AKR1C3-AKR1E2
Fusion gene ID: 3448
HgeneTgene
Gene symbol

AKR1C3

AKR1E2

Gene ID

8644

83592

Gene namealdo-keto reductase family 1 member C3aldo-keto reductase family 1 member E2
SynonymsDD3|DDX|HA1753|HAKRB|HAKRe|HSD17B5|PGFS|hluPGFSAKR1CL2|AKRDC1|LoopADR|TAKR|hTSP|htAKR
Cytomap

10p15.1

10p15.1

Type of geneprotein-codingprotein-coding
Descriptionaldo-keto reductase family 1 member C33-alpha hydroxysteroid dehydrogenase, type II3-alpha-HSD type II, brainchlordecone reductase homolog HAKRbdihydrodiol dehydrogenase 3dihydrodiol dehydrogenase Xindanol dehydrogenaseprostaglandin F synthasetest1,5-anhydro-D-fructose reductaseAF reductasealdo-keto reductase family 1 member C-like protein 2aldo-keto reductase family 1, member C-like 2aldo-keto reductase loopADRtestis aldo-keto reductasetestis-specific protein
Modification date2020032020200313
UniProtAcc

P42330

Q96JD6

Ensembl transtripts involved in fusion geneENST00000380554, ENST00000439082, 
ENST00000605149, ENST00000470862, 
ENST00000334019, ENST00000345253, 
ENST00000525281, ENST00000532248, 
ENST00000298375, 
Fusion gene scores* DoF score2 X 3 X 2=126 X 3 X 6=108
# samples 38
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(8/108*10)=-0.432959407276106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AKR1C3 [Title/Abstract] AND AKR1E2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAKR1C3(5144842)-AKR1E2(4877867), # samples:1
AKR1C3(5139742)-AKR1E2(4872867), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAKR1C3

GO:0007186

G protein-coupled receptor signaling pathway

18508192

HgeneAKR1C3

GO:0008284

positive regulation of cell proliferation

18508192|20036328

HgeneAKR1C3

GO:0010942

positive regulation of cell death

21787718

HgeneAKR1C3

GO:0016488

farnesol catabolic process

21187079

HgeneAKR1C3

GO:0034614

cellular response to reactive oxygen species

21787718

HgeneAKR1C3

GO:0042448

progesterone metabolic process

21232532

HgeneAKR1C3

GO:0042574

retinal metabolic process

21851338

HgeneAKR1C3

GO:0048385

regulation of retinoic acid receptor signaling pathway

21851338

HgeneAKR1C3

GO:0051897

positive regulation of protein kinase B signaling

18508192

HgeneAKR1C3

GO:0055114

oxidation-reduction process

16983398|19442656|21232532

HgeneAKR1C3

GO:0071276

cellular response to cadmium ion

21787718

HgeneAKR1C3

GO:0071277

cellular response to calcium ion

22170488

HgeneAKR1C3

GO:0071379

cellular response to prostaglandin stimulus

22170488

HgeneAKR1C3

GO:0071384

cellular response to corticosteroid stimulus

19336506

HgeneAKR1C3

GO:0071395

cellular response to jasmonic acid stimulus

19487289

HgeneAKR1C3

GO:0071799

cellular response to prostaglandin D stimulus

18508192

HgeneAKR1C3

GO:1900053

negative regulation of retinoic acid biosynthetic process

21851338

HgeneAKR1C3

GO:2000353

positive regulation of endothelial cell apoptotic process

19442656

HgeneAKR1C3

GO:2000379

positive regulation of reactive oxygen species metabolic process

19442656

TgeneAKR1E2

GO:0055114

oxidation-reduction process

15118078


check buttonFusion gene breakpoints across AKR1C3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AKR1E2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-66-2759-01AAKR1C3chr10

5144842

+AKR1E2chr10

4877867

+
ChimerDB4LUSCTCGA-68-A59J-01AAKR1C3chr10

5139742

+AKR1E2chr10

4872867

+


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Fusion Gene ORF analysis for AKR1C3-AKR1E2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000380554ENST00000334019AKR1C3chr10

5144842

+AKR1E2chr10

4877867

+
5CDS-3UTRENST00000380554ENST00000334019AKR1C3chr10

5139742

+AKR1E2chr10

4872867

+
5CDS-3UTRENST00000380554ENST00000345253AKR1C3chr10

5144842

+AKR1E2chr10

4877867

+
5CDS-3UTRENST00000380554ENST00000345253AKR1C3chr10

5139742

+AKR1E2chr10

4872867

+
5CDS-3UTRENST00000380554ENST00000525281AKR1C3chr10

5144842

+AKR1E2chr10

4877867

+
5CDS-3UTRENST00000380554ENST00000525281AKR1C3chr10

5139742

+AKR1E2chr10

4872867

+
5CDS-3UTRENST00000380554ENST00000532248AKR1C3chr10

5144842

+AKR1E2chr10

4877867

+
5CDS-3UTRENST00000380554ENST00000532248AKR1C3chr10

5139742

+AKR1E2chr10

4872867

+
5CDS-3UTRENST00000439082ENST00000334019AKR1C3chr10

5144842

+AKR1E2chr10

4877867

+
5CDS-3UTRENST00000439082ENST00000334019AKR1C3chr10

5139742

+AKR1E2chr10

4872867

+
5CDS-3UTRENST00000439082ENST00000345253AKR1C3chr10

5144842

+AKR1E2chr10

4877867

+
5CDS-3UTRENST00000439082ENST00000345253AKR1C3chr10

5139742

+AKR1E2chr10

4872867

+
5CDS-3UTRENST00000439082ENST00000525281AKR1C3chr10

5144842

+AKR1E2chr10

4877867

+
5CDS-3UTRENST00000439082ENST00000525281AKR1C3chr10

5139742

+AKR1E2chr10

4872867

+
5CDS-3UTRENST00000439082ENST00000532248AKR1C3chr10

5144842

+AKR1E2chr10

4877867

+
5CDS-3UTRENST00000439082ENST00000532248AKR1C3chr10

5139742

+AKR1E2chr10

4872867

+
5CDS-3UTRENST00000605149ENST00000334019AKR1C3chr10

5144842

+AKR1E2chr10

4877867

+
5CDS-3UTRENST00000605149ENST00000334019AKR1C3chr10

5139742

+AKR1E2chr10

4872867

+
5CDS-3UTRENST00000605149ENST00000345253AKR1C3chr10

5144842

+AKR1E2chr10

4877867

+
5CDS-3UTRENST00000605149ENST00000345253AKR1C3chr10

5139742

+AKR1E2chr10

4872867

+
5CDS-3UTRENST00000605149ENST00000525281AKR1C3chr10

5144842

+AKR1E2chr10

4877867

+
5CDS-3UTRENST00000605149ENST00000525281AKR1C3chr10

5139742

+AKR1E2chr10

4872867

+
5CDS-3UTRENST00000605149ENST00000532248AKR1C3chr10

5144842

+AKR1E2chr10

4877867

+
5CDS-3UTRENST00000605149ENST00000532248AKR1C3chr10

5139742

+AKR1E2chr10

4872867

+
In-frameENST00000380554ENST00000298375AKR1C3chr10

5144842

+AKR1E2chr10

4877867

+
In-frameENST00000380554ENST00000298375AKR1C3chr10

5139742

+AKR1E2chr10

4872867

+
In-frameENST00000439082ENST00000298375AKR1C3chr10

5144842

+AKR1E2chr10

4877867

+
In-frameENST00000439082ENST00000298375AKR1C3chr10

5139742

+AKR1E2chr10

4872867

+
In-frameENST00000605149ENST00000298375AKR1C3chr10

5144842

+AKR1E2chr10

4877867

+
In-frameENST00000605149ENST00000298375AKR1C3chr10

5139742

+AKR1E2chr10

4872867

+
intron-3CDSENST00000470862ENST00000298375AKR1C3chr10

5144842

+AKR1E2chr10

4877867

+
intron-3CDSENST00000470862ENST00000298375AKR1C3chr10

5139742

+AKR1E2chr10

4872867

+
intron-3UTRENST00000470862ENST00000334019AKR1C3chr10

5144842

+AKR1E2chr10

4877867

+
intron-3UTRENST00000470862ENST00000334019AKR1C3chr10

5139742

+AKR1E2chr10

4872867

+
intron-3UTRENST00000470862ENST00000345253AKR1C3chr10

5144842

+AKR1E2chr10

4877867

+
intron-3UTRENST00000470862ENST00000345253AKR1C3chr10

5139742

+AKR1E2chr10

4872867

+
intron-3UTRENST00000470862ENST00000525281AKR1C3chr10

5144842

+AKR1E2chr10

4877867

+
intron-3UTRENST00000470862ENST00000525281AKR1C3chr10

5139742

+AKR1E2chr10

4872867

+
intron-3UTRENST00000470862ENST00000532248AKR1C3chr10

5144842

+AKR1E2chr10

4877867

+
intron-3UTRENST00000470862ENST00000532248AKR1C3chr10

5139742

+AKR1E2chr10

4872867

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000605149AKR1C3chr105144842+ENST00000298375AKR1E2chr104877867+227311023251740471
ENST00000439082AKR1C3chr105144842+ENST00000298375AKR1E2chr104877867+21309591821597471
ENST00000380554AKR1C3chr105144842+ENST00000298375AKR1E2chr104877867+266914986522136494
ENST00000605149AKR1C3chr105139742+ENST00000298375AKR1E2chr104872867+20816253251548407
ENST00000439082AKR1C3chr105139742+ENST00000298375AKR1E2chr104872867+19384821821405407
ENST00000380554AKR1C3chr105139742+ENST00000298375AKR1E2chr104872867+247710216521944430

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000605149ENST00000298375AKR1C3chr105144842+AKR1E2chr104877867+0.0011166190.9988834
ENST00000439082ENST00000298375AKR1C3chr105144842+AKR1E2chr104877867+0.0014426480.9985574
ENST00000380554ENST00000298375AKR1C3chr105144842+AKR1E2chr104877867+0.0004348980.99956506
ENST00000605149ENST00000298375AKR1C3chr105139742+AKR1E2chr104872867+0.000613220.9993868
ENST00000439082ENST00000298375AKR1C3chr105139742+AKR1E2chr104872867+0.0007884010.99921155
ENST00000380554ENST00000298375AKR1C3chr105139742+AKR1E2chr104872867+0.0006289770.999371

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Fusion Genomic Features for AKR1C3-AKR1E2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
AKR1C3chr105139742+AKR1E2chr104872866+1.14E-050.99998856
AKR1C3chr105144842+AKR1E2chr104877866+4.16E-060.9999958
AKR1C3chr105139742+AKR1E2chr104872866+1.14E-050.99998856
AKR1C3chr105144842+AKR1E2chr104877866+4.16E-060.9999958

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for AKR1C3-AKR1E2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:5144842/chr10:4877867)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AKR1C3

P42330

AKR1E2

Q96JD6

FUNCTION: Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Acts as a NAD(P)(H)-dependent 3-, 17- and 20-ketosteroid reductase on the steroid nucleus and side chain and regulates the metabolism of androgens, estrogens and progesterone (PubMed:10622721, PubMed:11165022, PubMed:7650035, PubMed:9415401, PubMed:9927279). Displays the ability to catalyze both oxidation and reduction in vitro, but most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentration of NADPH (PubMed:14672942, PubMed:11165022). Acts preferentially as a 17-ketosteroid reductase and has the highest catalytic efficiency of the AKR1C enzyme for the reduction of delta4-androstenedione to form testosterone (PubMed:20036328). Reduces prostaglandin (PG) D2 to 11beta-prostaglandin F2, progesterone to 20alpha-hydroxyprogesterone and estrone to 17beta-estradiol (PubMed:15047184, PubMed:20036328, PubMed:10622721, PubMed:11165022, PubMed:10998348, PubMed:19010934). Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol) (PubMed:10998348, PubMed:14672942, PubMed:11165022, PubMed:7650035, PubMed:9415401, PubMed:10557352). Displays also retinaldehyde reductase activity toward 9-cis-retinal (PubMed:21851338). {ECO:0000269|PubMed:10557352, ECO:0000269|PubMed:10622721, ECO:0000269|PubMed:10998348, ECO:0000269|PubMed:11165022, ECO:0000269|PubMed:14672942, ECO:0000269|PubMed:15047184, ECO:0000269|PubMed:19010934, ECO:0000269|PubMed:20036328, ECO:0000269|PubMed:21851338, ECO:0000269|PubMed:7650035, ECO:0000269|PubMed:9415401, ECO:0000269|PubMed:9927279}.FUNCTION: Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol (By similarity). Has low NADPH-dependent reductase activity towards 9,10-phenanthrenequinone (in vitro) (PubMed:12604216, PubMed:15118078). {ECO:0000250|UniProtKB:Q9DCT1, ECO:0000269|PubMed:12604216, ECO:0000269|PubMed:15118078}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAKR1C3chr10:5139742chr10:4872867ENST00000380554+3923_24123324.0Nucleotide bindingNADP
HgeneAKR1C3chr10:5144842chr10:4877867ENST00000380554+79166_167282324.0Nucleotide bindingNADP
HgeneAKR1C3chr10:5144842chr10:4877867ENST00000380554+79216_222282324.0Nucleotide bindingNADP
HgeneAKR1C3chr10:5144842chr10:4877867ENST00000380554+7923_24282324.0Nucleotide bindingNADP
HgeneAKR1C3chr10:5144842chr10:4877867ENST00000380554+79270_272282324.0Nucleotide bindingNADP
HgeneAKR1C3chr10:5144842chr10:4877867ENST00000380554+79276_280282324.0Nucleotide bindingNADP
TgeneAKR1E2chr10:5139742chr10:4872867ENST00000298375010265_27713321.0Nucleotide bindingNADP
TgeneAKR1E2chr10:5139742chr10:4872867ENST0000033401908265_27713264.0Nucleotide bindingNADP
TgeneAKR1E2chr10:5139742chr10:4872867ENST0000034525307265_27713223.0Nucleotide bindingNADP
TgeneAKR1E2chr10:5139742chr10:4872867ENST0000053224807265_27713251.0Nucleotide bindingNADP
TgeneAKR1E2chr10:5144842chr10:4877867ENST00000298375210265_277108321.0Nucleotide bindingNADP
TgeneAKR1E2chr10:5144842chr10:4877867ENST0000033401928265_277108264.0Nucleotide bindingNADP
TgeneAKR1E2chr10:5144842chr10:4877867ENST0000034525327265_277108223.0Nucleotide bindingNADP
TgeneAKR1E2chr10:5144842chr10:4877867ENST0000053224827265_277108251.0Nucleotide bindingNADP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAKR1C3chr10:5139742chr10:4872867ENST00000380554+39166_167123324.0Nucleotide bindingNADP
HgeneAKR1C3chr10:5139742chr10:4872867ENST00000380554+39216_222123324.0Nucleotide bindingNADP
HgeneAKR1C3chr10:5139742chr10:4872867ENST00000380554+39270_272123324.0Nucleotide bindingNADP
HgeneAKR1C3chr10:5139742chr10:4872867ENST00000380554+39276_280123324.0Nucleotide bindingNADP


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Fusion Gene Sequence for AKR1C3-AKR1E2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3448_3448_1_AKR1C3-AKR1E2_AKR1C3_chr10_5139742_ENST00000380554_AKR1E2_chr10_4872867_ENST00000298375_length(transcript)=2477nt_BP=1021nt
CCCTCATCAGGATTACAGCTTTATCAGGACTGCATCTTCTTCAGAAATGAATATTTCTCTTACAACGCAAAGAAAGAAAAATCAAAATAA
ATTTTCTGATTGAAAATGTAAAAAGGCAAATATTTTTACAGTTTTAACTTTAATTTTTTATTGAGGACCAACTATTTGAAAAATTCTCAT
TAGTCATTCCTTTAAATTATGTGTATGTGAGAGAAAGACGTAAGATGGTTAATTATTTCAAATGATGCAGTATAAAGAAGGGGCATTATC
ACGGCAGAAACGAAAAAAGATATTTGTAGCTGGAGGTTTTTATAGTCTAACATATGGTTGCTATTTGTTCTACAAATCCTTTTGAATAAT
TTAATATAGAGATTTAGAATAGAAAATAATACTTTAGATAGAAATTAATGAGTTTATTATAACCATATATTATAATAATTTACTTAGGAA
TTCTCTTTGATAAGAAACAAATGAACTGAATGCAATTTTCTCCACAGACCATATAAGACTGCCTATGTACCTCCTCCTACATGCCATTGG
TTAACCATCAGTCAGTTTGCAGGGGTGGGGGGAGGGGTTTCCTGCCCATTGTTTTTGTAATCTCTGAGGAGAAGCAGCAGCAAACATTTG
CTAGTCAGACAAGTGACAGGGAATGGATTCCAAACACCAGTGTGTAAAGCTAAATGATGGCCACTTCATGCCTGTATTGGGATTTGGCAC
CTATGCACCTCCAGAGGTTCCGAGAAGTAAAGCTTTGGAGGTCACAAAATTAGCAATAGAAGCTGGGTTCCGCCATATAGATTCTGCTCA
TTTATACAATAATGAGGAGCAGGTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTCTACACTTC
AAAGCTTTGGTCCACTTTTCATCGACCAGAGTTGGTCCGACCAGCCTTGGAAAACTCACTGAAGAAAGCTCAATTGGACTATGTTGACCT
CTATCTTATTCATTCTCCAATGTCTCTAAAGGCTTCTCCAGGGAAAGTGACCGAGGCAGTGAAAGAGGCCATTGACGCAGGGTACCGGCA
CTTCGACTGTGCTTACTTTTACCACAATGAGAGGGAGGTTGGAGCAGGGATCCGTTGCAAGATCAAGGAAGGCGCTGTAAGACGGGAGGA
TCTGTTCATTGCCACTAAGCTGTGGTGCACCTGCCATAAGAAGTCCTTGGTGGAAACAGCATGCAGAAAGAGTCTCAAGGCCTTGAAGCT
GAACTATTTGGACCTCTACCTCATACACTGGCCCATGGGTTTCAAGCCTCCTCATCCAGAATGGATCATGAGCTGCAGTGAACTTTCCTT
CTGCCTCTCACATCCTCGAGTGCAGGACTTGCCTCTGGACGAGAGCAACATGGTTATTCCCAGTGACACGGACTTCCTGGACACGTGGGA
GGCCATGGAGGACCTGGTGATCACCGGGCTGGTGAAGAACATCGGGGTGTCAAACTTCAACCATGAACAGCTTGAGAGGCTTTTGAATAA
GCCTGGGTTGAGGTTCAAGCCACTAACCAACCAGATTGAGTGCCACCCATATCTTACTCAGAAGAATCTGATCAGTTTTTGCCAATCCAG
AGATGTGTCCGTGACTGCTTACCGTCCTCTTGGTGGCTCGTGTGAGGGGGTTGACCTGATAGACAACCCTGTGATCAAGAGGATTGCAAA
GGAGCACGGCAAGTCTCCTGCTCAGATTTTGATCCGATTTCAAATCCAGAGGAATGTGATAGTGATCCCCGGATCTATCACCCCAAGTCA
CATTAAAGAGAATATCCAGGTGTTTGATTTTGAATTAACACAGCACGATATGGATAACATCCTCAGCCTAAACAGGAATCTCCGACTGGC
CATGTTCCCCATAACTAAAAATCACAAAGACTATCCTTTCCACATAGAATACTGAGGACGCTTCCCCTTCCTTGTTTCTGCTCAGCCCAG
ATGCACAGACACTATTGGCAATGTTGACCCTCCTCTGTCATCACAGCGCCAGGGCAGCTGTGCCTGGGACAGGAGCCACACAGTCAGAGG
GGGATGTAAGAGCCACCTTCTCTGACAAATCTGGAGAATTGAGTGTGTTCTAAGTGAAGGCAATGGGGTTTCTCCAAGACAGCCTGTGTG
GCCTCTACTCTGAACAAATACACTGATGAGTCATCAGTGAAATTTGCCTTCACATTTTAAGAAAACTTTATCTTATGGAGTTATTTAAGC
CATCTACAGAGCTGAGGAAACAGTGTAATGTGTCTCTGCCCCATTGCGCAGCTCCACCCATTGTGCCCCAGGCCAGCCCGCGTCACCTAC
ACTTCCTTCTGTGCCCTGCCAGTGACCCCCAGGTTATTCTAAAGCAGAGTCCTTCCCTTCCCCCAGTGAGAAGGAAAATGGGATAAGTCT

>3448_3448_1_AKR1C3-AKR1E2_AKR1C3_chr10_5139742_ENST00000380554_AKR1E2_chr10_4872867_ENST00000298375_length(amino acids)=430AA_BP=121
MDSKHQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFH
RPELVRPALENSLKKAQLDYVDLYLIHSPMSLKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKL
WCTCHKKSLVETACRKSLKALKLNYLDLYLIHWPMGFKPPHPEWIMSCSELSFCLSHPRVQDLPLDESNMVIPSDTDFLDTWEAMEDLVI
TGLVKNIGVSNFNHEQLERLLNKPGLRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSCEGVDLIDNPVIKRIAKEHGKSPA

--------------------------------------------------------------
>3448_3448_2_AKR1C3-AKR1E2_AKR1C3_chr10_5139742_ENST00000439082_AKR1E2_chr10_4872867_ENST00000298375_length(transcript)=1938nt_BP=482nt
AACATGTTCCTTGAGGTTGAAGCAAATCTGACCGATTTTCAATGTAAAAATAACATATAAAAACTGTTCTCGGAGTTATTTCTAAACAGA
ACTAAGATCAGAATTCTTTGAATCATCAGAATCATCTCTTTTGAAAAATCGATTCATCAAATGAATCTTCAGCCAACAACTGTTCAAGAA
GGATGCAAATATCACAGGTTCCGAGAAGTAAAGCTTTGGAGGTCACAAAATTAGCAATAGAAGCTGGGTTCCGCCATATAGATTCTGCTC
ATTTATACAATAATGAGGAGCAGGTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTCTACACTT
CAAAGCTTTGGTCCACTTTTCATCGACCAGAGTTGGTCCGACCAGCCTTGGAAAACTCACTGAAGAAAGCTCAATTGGACTATGTTGACC
TCTATCTTATTCATTCTCCAATGTCTCTAAAGGCTTCTCCAGGGAAAGTGACCGAGGCAGTGAAAGAGGCCATTGACGCAGGGTACCGGC
ACTTCGACTGTGCTTACTTTTACCACAATGAGAGGGAGGTTGGAGCAGGGATCCGTTGCAAGATCAAGGAAGGCGCTGTAAGACGGGAGG
ATCTGTTCATTGCCACTAAGCTGTGGTGCACCTGCCATAAGAAGTCCTTGGTGGAAACAGCATGCAGAAAGAGTCTCAAGGCCTTGAAGC
TGAACTATTTGGACCTCTACCTCATACACTGGCCCATGGGTTTCAAGCCTCCTCATCCAGAATGGATCATGAGCTGCAGTGAACTTTCCT
TCTGCCTCTCACATCCTCGAGTGCAGGACTTGCCTCTGGACGAGAGCAACATGGTTATTCCCAGTGACACGGACTTCCTGGACACGTGGG
AGGCCATGGAGGACCTGGTGATCACCGGGCTGGTGAAGAACATCGGGGTGTCAAACTTCAACCATGAACAGCTTGAGAGGCTTTTGAATA
AGCCTGGGTTGAGGTTCAAGCCACTAACCAACCAGATTGAGTGCCACCCATATCTTACTCAGAAGAATCTGATCAGTTTTTGCCAATCCA
GAGATGTGTCCGTGACTGCTTACCGTCCTCTTGGTGGCTCGTGTGAGGGGGTTGACCTGATAGACAACCCTGTGATCAAGAGGATTGCAA
AGGAGCACGGCAAGTCTCCTGCTCAGATTTTGATCCGATTTCAAATCCAGAGGAATGTGATAGTGATCCCCGGATCTATCACCCCAAGTC
ACATTAAAGAGAATATCCAGGTGTTTGATTTTGAATTAACACAGCACGATATGGATAACATCCTCAGCCTAAACAGGAATCTCCGACTGG
CCATGTTCCCCATAACTAAAAATCACAAAGACTATCCTTTCCACATAGAATACTGAGGACGCTTCCCCTTCCTTGTTTCTGCTCAGCCCA
GATGCACAGACACTATTGGCAATGTTGACCCTCCTCTGTCATCACAGCGCCAGGGCAGCTGTGCCTGGGACAGGAGCCACACAGTCAGAG
GGGGATGTAAGAGCCACCTTCTCTGACAAATCTGGAGAATTGAGTGTGTTCTAAGTGAAGGCAATGGGGTTTCTCCAAGACAGCCTGTGT
GGCCTCTACTCTGAACAAATACACTGATGAGTCATCAGTGAAATTTGCCTTCACATTTTAAGAAAACTTTATCTTATGGAGTTATTTAAG
CCATCTACAGAGCTGAGGAAACAGTGTAATGTGTCTCTGCCCCATTGCGCAGCTCCACCCATTGTGCCCCAGGCCAGCCCGCGTCACCTA
CACTTCCTTCTGTGCCCTGCCAGTGACCCCCAGGTTATTCTAAAGCAGAGTCCTTCCCTTCCCCCAGTGAGAAGGAAAATGGGATAAGTC

>3448_3448_2_AKR1C3-AKR1E2_AKR1C3_chr10_5139742_ENST00000439082_AKR1E2_chr10_4872867_ENST00000298375_length(amino acids)=407AA_BP=98
MQISQVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDL
YLIHSPMSLKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLVETACRKSLKALKL
NYLDLYLIHWPMGFKPPHPEWIMSCSELSFCLSHPRVQDLPLDESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNK
PGLRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSCEGVDLIDNPVIKRIAKEHGKSPAQILIRFQIQRNVIVIPGSITPSH

--------------------------------------------------------------
>3448_3448_3_AKR1C3-AKR1E2_AKR1C3_chr10_5139742_ENST00000605149_AKR1E2_chr10_4872867_ENST00000298375_length(transcript)=2081nt_BP=625nt
TTTTTGCTGAACATTCCCCTTAGTAAAATGGCAGGATGGTTTGCTTGCCATTGAAACTAACCAAACATTTAATCCTTTTCCCTTTAGAGA
AAAAAGAAAAAAAAAGGTGCAGCTCACTGCCAGTGCCCATTTAGTTTTACATTAACATGTTCCTTGAGGTTGAAGCAAATCTGACCGATT
TTCAATGTAAAAATAACATATAAAAACTGTTCTCGGAGTTATTTCTAAACAGAACTAAGATCAGAATTCTTTGAATCATCAGAATCATCT
CTTTTGAAAAATCGATTCATCAAATGAATCTTCAGCCAACAACTGTTCAAGAAGGATGCAAATATCACAGGTTCCGAGAAGTAAAGCTTT
GGAGGTCACAAAATTAGCAATAGAAGCTGGGTTCCGCCATATAGATTCTGCTCATTTATACAATAATGAGGAGCAGGTTGGACTGGCCAT
CCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTCTACACTTCAAAGCTTTGGTCCACTTTTCATCGACCAGAGTTGGT
CCGACCAGCCTTGGAAAACTCACTGAAGAAAGCTCAATTGGACTATGTTGACCTCTATCTTATTCATTCTCCAATGTCTCTAAAGGCTTC
TCCAGGGAAAGTGACCGAGGCAGTGAAAGAGGCCATTGACGCAGGGTACCGGCACTTCGACTGTGCTTACTTTTACCACAATGAGAGGGA
GGTTGGAGCAGGGATCCGTTGCAAGATCAAGGAAGGCGCTGTAAGACGGGAGGATCTGTTCATTGCCACTAAGCTGTGGTGCACCTGCCA
TAAGAAGTCCTTGGTGGAAACAGCATGCAGAAAGAGTCTCAAGGCCTTGAAGCTGAACTATTTGGACCTCTACCTCATACACTGGCCCAT
GGGTTTCAAGCCTCCTCATCCAGAATGGATCATGAGCTGCAGTGAACTTTCCTTCTGCCTCTCACATCCTCGAGTGCAGGACTTGCCTCT
GGACGAGAGCAACATGGTTATTCCCAGTGACACGGACTTCCTGGACACGTGGGAGGCCATGGAGGACCTGGTGATCACCGGGCTGGTGAA
GAACATCGGGGTGTCAAACTTCAACCATGAACAGCTTGAGAGGCTTTTGAATAAGCCTGGGTTGAGGTTCAAGCCACTAACCAACCAGAT
TGAGTGCCACCCATATCTTACTCAGAAGAATCTGATCAGTTTTTGCCAATCCAGAGATGTGTCCGTGACTGCTTACCGTCCTCTTGGTGG
CTCGTGTGAGGGGGTTGACCTGATAGACAACCCTGTGATCAAGAGGATTGCAAAGGAGCACGGCAAGTCTCCTGCTCAGATTTTGATCCG
ATTTCAAATCCAGAGGAATGTGATAGTGATCCCCGGATCTATCACCCCAAGTCACATTAAAGAGAATATCCAGGTGTTTGATTTTGAATT
AACACAGCACGATATGGATAACATCCTCAGCCTAAACAGGAATCTCCGACTGGCCATGTTCCCCATAACTAAAAATCACAAAGACTATCC
TTTCCACATAGAATACTGAGGACGCTTCCCCTTCCTTGTTTCTGCTCAGCCCAGATGCACAGACACTATTGGCAATGTTGACCCTCCTCT
GTCATCACAGCGCCAGGGCAGCTGTGCCTGGGACAGGAGCCACACAGTCAGAGGGGGATGTAAGAGCCACCTTCTCTGACAAATCTGGAG
AATTGAGTGTGTTCTAAGTGAAGGCAATGGGGTTTCTCCAAGACAGCCTGTGTGGCCTCTACTCTGAACAAATACACTGATGAGTCATCA
GTGAAATTTGCCTTCACATTTTAAGAAAACTTTATCTTATGGAGTTATTTAAGCCATCTACAGAGCTGAGGAAACAGTGTAATGTGTCTC
TGCCCCATTGCGCAGCTCCACCCATTGTGCCCCAGGCCAGCCCGCGTCACCTACACTTCCTTCTGTGCCCTGCCAGTGACCCCCAGGTTA
TTCTAAAGCAGAGTCCTTCCCTTCCCCCAGTGAGAAGGAAAATGGGATAAGTCTGGGACACTGTTTCAGTTCAATAAAGAGGCTTTTTTC

>3448_3448_3_AKR1C3-AKR1E2_AKR1C3_chr10_5139742_ENST00000605149_AKR1E2_chr10_4872867_ENST00000298375_length(amino acids)=407AA_BP=98
MQISQVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDL
YLIHSPMSLKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLVETACRKSLKALKL
NYLDLYLIHWPMGFKPPHPEWIMSCSELSFCLSHPRVQDLPLDESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNK
PGLRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSCEGVDLIDNPVIKRIAKEHGKSPAQILIRFQIQRNVIVIPGSITPSH

--------------------------------------------------------------
>3448_3448_4_AKR1C3-AKR1E2_AKR1C3_chr10_5144842_ENST00000380554_AKR1E2_chr10_4877867_ENST00000298375_length(transcript)=2669nt_BP=1498nt
CCCTCATCAGGATTACAGCTTTATCAGGACTGCATCTTCTTCAGAAATGAATATTTCTCTTACAACGCAAAGAAAGAAAAATCAAAATAA
ATTTTCTGATTGAAAATGTAAAAAGGCAAATATTTTTACAGTTTTAACTTTAATTTTTTATTGAGGACCAACTATTTGAAAAATTCTCAT
TAGTCATTCCTTTAAATTATGTGTATGTGAGAGAAAGACGTAAGATGGTTAATTATTTCAAATGATGCAGTATAAAGAAGGGGCATTATC
ACGGCAGAAACGAAAAAAGATATTTGTAGCTGGAGGTTTTTATAGTCTAACATATGGTTGCTATTTGTTCTACAAATCCTTTTGAATAAT
TTAATATAGAGATTTAGAATAGAAAATAATACTTTAGATAGAAATTAATGAGTTTATTATAACCATATATTATAATAATTTACTTAGGAA
TTCTCTTTGATAAGAAACAAATGAACTGAATGCAATTTTCTCCACAGACCATATAAGACTGCCTATGTACCTCCTCCTACATGCCATTGG
TTAACCATCAGTCAGTTTGCAGGGGTGGGGGGAGGGGTTTCCTGCCCATTGTTTTTGTAATCTCTGAGGAGAAGCAGCAGCAAACATTTG
CTAGTCAGACAAGTGACAGGGAATGGATTCCAAACACCAGTGTGTAAAGCTAAATGATGGCCACTTCATGCCTGTATTGGGATTTGGCAC
CTATGCACCTCCAGAGGTTCCGAGAAGTAAAGCTTTGGAGGTCACAAAATTAGCAATAGAAGCTGGGTTCCGCCATATAGATTCTGCTCA
TTTATACAATAATGAGGAGCAGGTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTCTACACTTC
AAAGCTTTGGTCCACTTTTCATCGACCAGAGTTGGTCCGACCAGCCTTGGAAAACTCACTGAAGAAAGCTCAATTGGACTATGTTGACCT
CTATCTTATTCATTCTCCAATGTCTCTAAAGCCAGGTGAGGAACTTTCACCAACAGATGAAAATGGAAAAGTAATATTTGACATAGTGGA
TCTCTGTACCACCTGGGAGGCCATGGAGAAGTGTAAGGATGCAGGATTGGCCAAGTCCATTGGGGTGTCAAACTTCAACCGCAGGCAGCT
GGAGATGATCCTCAACAAGCCAGGACTCAAGTACAAGCCTGTCTGCAACCAGGTAGAATGTCATCCGTATTTCAACCGGAGTAAATTGCT
AGATTTCTGCAAGTCGAAAGATATTGTTCTGGTTGCCTATAGTGCTCTGGGATCTCAACGAGACAAACGATGGGTGGACCCGAACTCCCC
GGTGCTCTTGGAGGACCCAGTCCTTTGTGCCTTGGCAAAAAAGCACAAGCGAACCCCAGCCCTGATTGCCCTGCGCTACCAGCTGCAGCG
TGGGGTTGTGGTCCTGGCCAAGAGCTACAATGAGCAGCGCATCAGACAGAACGTGCAGCCTCCTCATCCAGAATGGATCATGAGCTGCAG
TGAACTTTCCTTCTGCCTCTCACATCCTCGAGTGCAGGACTTGCCTCTGGACGAGAGCAACATGGTTATTCCCAGTGACACGGACTTCCT
GGACACGTGGGAGGCCATGGAGGACCTGGTGATCACCGGGCTGGTGAAGAACATCGGGGTGTCAAACTTCAACCATGAACAGCTTGAGAG
GCTTTTGAATAAGCCTGGGTTGAGGTTCAAGCCACTAACCAACCAGATTGAGTGCCACCCATATCTTACTCAGAAGAATCTGATCAGTTT
TTGCCAATCCAGAGATGTGTCCGTGACTGCTTACCGTCCTCTTGGTGGCTCGTGTGAGGGGGTTGACCTGATAGACAACCCTGTGATCAA
GAGGATTGCAAAGGAGCACGGCAAGTCTCCTGCTCAGATTTTGATCCGATTTCAAATCCAGAGGAATGTGATAGTGATCCCCGGATCTAT
CACCCCAAGTCACATTAAAGAGAATATCCAGGTGTTTGATTTTGAATTAACACAGCACGATATGGATAACATCCTCAGCCTAAACAGGAA
TCTCCGACTGGCCATGTTCCCCATAACTAAAAATCACAAAGACTATCCTTTCCACATAGAATACTGAGGACGCTTCCCCTTCCTTGTTTC
TGCTCAGCCCAGATGCACAGACACTATTGGCAATGTTGACCCTCCTCTGTCATCACAGCGCCAGGGCAGCTGTGCCTGGGACAGGAGCCA
CACAGTCAGAGGGGGATGTAAGAGCCACCTTCTCTGACAAATCTGGAGAATTGAGTGTGTTCTAAGTGAAGGCAATGGGGTTTCTCCAAG
ACAGCCTGTGTGGCCTCTACTCTGAACAAATACACTGATGAGTCATCAGTGAAATTTGCCTTCACATTTTAAGAAAACTTTATCTTATGG
AGTTATTTAAGCCATCTACAGAGCTGAGGAAACAGTGTAATGTGTCTCTGCCCCATTGCGCAGCTCCACCCATTGTGCCCCAGGCCAGCC
CGCGTCACCTACACTTCCTTCTGTGCCCTGCCAGTGACCCCCAGGTTATTCTAAAGCAGAGTCCTTCCCTTCCCCCAGTGAGAAGGAAAA

>3448_3448_4_AKR1C3-AKR1E2_AKR1C3_chr10_5144842_ENST00000380554_AKR1E2_chr10_4877867_ENST00000298375_length(amino acids)=494AA_BP=281
MDSKHQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFH
RPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP
GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAK
SYNEQRIRQNVQPPHPEWIMSCSELSFCLSHPRVQDLPLDESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGL
RFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSCEGVDLIDNPVIKRIAKEHGKSPAQILIRFQIQRNVIVIPGSITPSHIKE

--------------------------------------------------------------
>3448_3448_5_AKR1C3-AKR1E2_AKR1C3_chr10_5144842_ENST00000439082_AKR1E2_chr10_4877867_ENST00000298375_length(transcript)=2130nt_BP=959nt
AACATGTTCCTTGAGGTTGAAGCAAATCTGACCGATTTTCAATGTAAAAATAACATATAAAAACTGTTCTCGGAGTTATTTCTAAACAGA
ACTAAGATCAGAATTCTTTGAATCATCAGAATCATCTCTTTTGAAAAATCGATTCATCAAATGAATCTTCAGCCAACAACTGTTCAAGAA
GGATGCAAATATCACAGGTTCCGAGAAGTAAAGCTTTGGAGGTCACAAAATTAGCAATAGAAGCTGGGTTCCGCCATATAGATTCTGCTC
ATTTATACAATAATGAGGAGCAGGTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTCTACACTT
CAAAGCTTTGGTCCACTTTTCATCGACCAGAGTTGGTCCGACCAGCCTTGGAAAACTCACTGAAGAAAGCTCAATTGGACTATGTTGACC
TCTATCTTATTCATTCTCCAATGTCTCTAAAGCCAGGTGAGGAACTTTCACCAACAGATGAAAATGGAAAAGTAATATTTGACATAGTGG
ATCTCTGTACCACCTGGGAGGCCATGGAGAAGTGTAAGGATGCAGGATTGGCCAAGTCCATTGGGGTGTCAAACTTCAACCGCAGGCAGC
TGGAGATGATCCTCAACAAGCCAGGACTCAAGTACAAGCCTGTCTGCAACCAGGTAGAATGTCATCCGTATTTCAACCGGAGTAAATTGC
TAGATTTCTGCAAGTCGAAAGATATTGTTCTGGTTGCCTATAGTGCTCTGGGATCTCAACGAGACAAACGATGGGTGGACCCGAACTCCC
CGGTGCTCTTGGAGGACCCAGTCCTTTGTGCCTTGGCAAAAAAGCACAAGCGAACCCCAGCCCTGATTGCCCTGCGCTACCAGCTGCAGC
GTGGGGTTGTGGTCCTGGCCAAGAGCTACAATGAGCAGCGCATCAGACAGAACGTGCAGCCTCCTCATCCAGAATGGATCATGAGCTGCA
GTGAACTTTCCTTCTGCCTCTCACATCCTCGAGTGCAGGACTTGCCTCTGGACGAGAGCAACATGGTTATTCCCAGTGACACGGACTTCC
TGGACACGTGGGAGGCCATGGAGGACCTGGTGATCACCGGGCTGGTGAAGAACATCGGGGTGTCAAACTTCAACCATGAACAGCTTGAGA
GGCTTTTGAATAAGCCTGGGTTGAGGTTCAAGCCACTAACCAACCAGATTGAGTGCCACCCATATCTTACTCAGAAGAATCTGATCAGTT
TTTGCCAATCCAGAGATGTGTCCGTGACTGCTTACCGTCCTCTTGGTGGCTCGTGTGAGGGGGTTGACCTGATAGACAACCCTGTGATCA
AGAGGATTGCAAAGGAGCACGGCAAGTCTCCTGCTCAGATTTTGATCCGATTTCAAATCCAGAGGAATGTGATAGTGATCCCCGGATCTA
TCACCCCAAGTCACATTAAAGAGAATATCCAGGTGTTTGATTTTGAATTAACACAGCACGATATGGATAACATCCTCAGCCTAAACAGGA
ATCTCCGACTGGCCATGTTCCCCATAACTAAAAATCACAAAGACTATCCTTTCCACATAGAATACTGAGGACGCTTCCCCTTCCTTGTTT
CTGCTCAGCCCAGATGCACAGACACTATTGGCAATGTTGACCCTCCTCTGTCATCACAGCGCCAGGGCAGCTGTGCCTGGGACAGGAGCC
ACACAGTCAGAGGGGGATGTAAGAGCCACCTTCTCTGACAAATCTGGAGAATTGAGTGTGTTCTAAGTGAAGGCAATGGGGTTTCTCCAA
GACAGCCTGTGTGGCCTCTACTCTGAACAAATACACTGATGAGTCATCAGTGAAATTTGCCTTCACATTTTAAGAAAACTTTATCTTATG
GAGTTATTTAAGCCATCTACAGAGCTGAGGAAACAGTGTAATGTGTCTCTGCCCCATTGCGCAGCTCCACCCATTGTGCCCCAGGCCAGC
CCGCGTCACCTACACTTCCTTCTGTGCCCTGCCAGTGACCCCCAGGTTATTCTAAAGCAGAGTCCTTCCCTTCCCCCAGTGAGAAGGAAA

>3448_3448_5_AKR1C3-AKR1E2_AKR1C3_chr10_5144842_ENST00000439082_AKR1E2_chr10_4877867_ENST00000298375_length(amino acids)=471AA_BP=258
MQISQVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDL
YLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLL
DFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQPPHPEWIMSCS
ELSFCLSHPRVQDLPLDESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLRFKPLTNQIECHPYLTQKNLISF
CQSRDVSVTAYRPLGGSCEGVDLIDNPVIKRIAKEHGKSPAQILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRN

--------------------------------------------------------------
>3448_3448_6_AKR1C3-AKR1E2_AKR1C3_chr10_5144842_ENST00000605149_AKR1E2_chr10_4877867_ENST00000298375_length(transcript)=2273nt_BP=1102nt
TTTTTGCTGAACATTCCCCTTAGTAAAATGGCAGGATGGTTTGCTTGCCATTGAAACTAACCAAACATTTAATCCTTTTCCCTTTAGAGA
AAAAAGAAAAAAAAAGGTGCAGCTCACTGCCAGTGCCCATTTAGTTTTACATTAACATGTTCCTTGAGGTTGAAGCAAATCTGACCGATT
TTCAATGTAAAAATAACATATAAAAACTGTTCTCGGAGTTATTTCTAAACAGAACTAAGATCAGAATTCTTTGAATCATCAGAATCATCT
CTTTTGAAAAATCGATTCATCAAATGAATCTTCAGCCAACAACTGTTCAAGAAGGATGCAAATATCACAGGTTCCGAGAAGTAAAGCTTT
GGAGGTCACAAAATTAGCAATAGAAGCTGGGTTCCGCCATATAGATTCTGCTCATTTATACAATAATGAGGAGCAGGTTGGACTGGCCAT
CCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTCTACACTTCAAAGCTTTGGTCCACTTTTCATCGACCAGAGTTGGT
CCGACCAGCCTTGGAAAACTCACTGAAGAAAGCTCAATTGGACTATGTTGACCTCTATCTTATTCATTCTCCAATGTCTCTAAAGCCAGG
TGAGGAACTTTCACCAACAGATGAAAATGGAAAAGTAATATTTGACATAGTGGATCTCTGTACCACCTGGGAGGCCATGGAGAAGTGTAA
GGATGCAGGATTGGCCAAGTCCATTGGGGTGTCAAACTTCAACCGCAGGCAGCTGGAGATGATCCTCAACAAGCCAGGACTCAAGTACAA
GCCTGTCTGCAACCAGGTAGAATGTCATCCGTATTTCAACCGGAGTAAATTGCTAGATTTCTGCAAGTCGAAAGATATTGTTCTGGTTGC
CTATAGTGCTCTGGGATCTCAACGAGACAAACGATGGGTGGACCCGAACTCCCCGGTGCTCTTGGAGGACCCAGTCCTTTGTGCCTTGGC
AAAAAAGCACAAGCGAACCCCAGCCCTGATTGCCCTGCGCTACCAGCTGCAGCGTGGGGTTGTGGTCCTGGCCAAGAGCTACAATGAGCA
GCGCATCAGACAGAACGTGCAGCCTCCTCATCCAGAATGGATCATGAGCTGCAGTGAACTTTCCTTCTGCCTCTCACATCCTCGAGTGCA
GGACTTGCCTCTGGACGAGAGCAACATGGTTATTCCCAGTGACACGGACTTCCTGGACACGTGGGAGGCCATGGAGGACCTGGTGATCAC
CGGGCTGGTGAAGAACATCGGGGTGTCAAACTTCAACCATGAACAGCTTGAGAGGCTTTTGAATAAGCCTGGGTTGAGGTTCAAGCCACT
AACCAACCAGATTGAGTGCCACCCATATCTTACTCAGAAGAATCTGATCAGTTTTTGCCAATCCAGAGATGTGTCCGTGACTGCTTACCG
TCCTCTTGGTGGCTCGTGTGAGGGGGTTGACCTGATAGACAACCCTGTGATCAAGAGGATTGCAAAGGAGCACGGCAAGTCTCCTGCTCA
GATTTTGATCCGATTTCAAATCCAGAGGAATGTGATAGTGATCCCCGGATCTATCACCCCAAGTCACATTAAAGAGAATATCCAGGTGTT
TGATTTTGAATTAACACAGCACGATATGGATAACATCCTCAGCCTAAACAGGAATCTCCGACTGGCCATGTTCCCCATAACTAAAAATCA
CAAAGACTATCCTTTCCACATAGAATACTGAGGACGCTTCCCCTTCCTTGTTTCTGCTCAGCCCAGATGCACAGACACTATTGGCAATGT
TGACCCTCCTCTGTCATCACAGCGCCAGGGCAGCTGTGCCTGGGACAGGAGCCACACAGTCAGAGGGGGATGTAAGAGCCACCTTCTCTG
ACAAATCTGGAGAATTGAGTGTGTTCTAAGTGAAGGCAATGGGGTTTCTCCAAGACAGCCTGTGTGGCCTCTACTCTGAACAAATACACT
GATGAGTCATCAGTGAAATTTGCCTTCACATTTTAAGAAAACTTTATCTTATGGAGTTATTTAAGCCATCTACAGAGCTGAGGAAACAGT
GTAATGTGTCTCTGCCCCATTGCGCAGCTCCACCCATTGTGCCCCAGGCCAGCCCGCGTCACCTACACTTCCTTCTGTGCCCTGCCAGTG
ACCCCCAGGTTATTCTAAAGCAGAGTCCTTCCCTTCCCCCAGTGAGAAGGAAAATGGGATAAGTCTGGGACACTGTTTCAGTTCAATAAA

>3448_3448_6_AKR1C3-AKR1E2_AKR1C3_chr10_5144842_ENST00000605149_AKR1E2_chr10_4877867_ENST00000298375_length(amino acids)=471AA_BP=258
MQISQVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDL
YLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLL
DFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQPPHPEWIMSCS
ELSFCLSHPRVQDLPLDESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLRFKPLTNQIECHPYLTQKNLISF
CQSRDVSVTAYRPLGGSCEGVDLIDNPVIKRIAKEHGKSPAQILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AKR1C3-AKR1E2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AKR1C3-AKR1E2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AKR1C3-AKR1E2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource