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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GRAMD1A-FXYD3 (FusionGDB2 ID:34574)

Fusion Gene Summary for GRAMD1A-FXYD3

Fusion gene summary

Fusion gene information	Fusion gene name: GRAMD1A-FXYD3
	Fusion gene ID: 34574
		Hgene	Tgene
	Gene symbol	GRAMD1A	FXYD3
	Gene ID	57655	5349
	Gene name	GRAM domain containing 1A	FXYD domain containing ion transport regulator 3
	Synonyms	KIAA1533	MAT8\|PLML
	Cytomap	19q13.11	19q13.12
	Type of gene	protein-coding	protein-coding
	Description	protein Aster-AGRAM domain-containing protein 1A	FXYD domain-containing ion transport regulator 3chloride conductance inducer protein Mat-8mammary tumor 8 kDa proteinphospholemman-like proteinsodium/potassium-transporting ATPase subunit FXYD3
	Modification date	20200313	20200313
	UniProtAcc	Q96CP6	Q14802
	Ensembl transtripts involved in fusion gene	ENST00000317991, ENST00000411896, ENST00000504615, ENST00000599564, ENST00000424536, ENST00000598073,	ENST00000344013, ENST00000346446, ENST00000406242, ENST00000406988, ENST00000435734, ENST00000454903, ENST00000535103, ENST00000603181, ENST00000603449, ENST00000603524, ENST00000604255, ENST00000604404, ENST00000604621, ENST00000604804, ENST00000605550, ENST00000605552, ENST00000605677,
Fusion gene scores	* DoF score	5 X 3 X 5=75	9 X 10 X 8=720
	# samples	6	11
	** MAII score	log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/720*10)=-2.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GRAMD1A [Title/Abstract] AND FXYD3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GRAMD1A(35505291)-FXYD3(35613668), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across GRAMD1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FXYD3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-24-1419	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+

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Fusion Gene ORF analysis for GRAMD1A-FXYD3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000317991	ENST00000344013	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000317991	ENST00000346446	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000317991	ENST00000406242	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000317991	ENST00000406988	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000317991	ENST00000435734	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000317991	ENST00000454903	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000317991	ENST00000535103	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000317991	ENST00000603181	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000317991	ENST00000603449	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000317991	ENST00000603524	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000317991	ENST00000604255	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000317991	ENST00000604404	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000317991	ENST00000604621	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000317991	ENST00000604804	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000317991	ENST00000605550	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000317991	ENST00000605552	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000317991	ENST00000605677	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000411896	ENST00000344013	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000411896	ENST00000346446	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000411896	ENST00000406242	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000411896	ENST00000406988	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000411896	ENST00000435734	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000411896	ENST00000454903	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000411896	ENST00000535103	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000411896	ENST00000603181	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000411896	ENST00000603449	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000411896	ENST00000603524	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000411896	ENST00000604255	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000411896	ENST00000604404	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000411896	ENST00000604621	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000411896	ENST00000604804	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000411896	ENST00000605550	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000411896	ENST00000605552	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000411896	ENST00000605677	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000504615	ENST00000344013	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000504615	ENST00000346446	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000504615	ENST00000406242	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000504615	ENST00000406988	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000504615	ENST00000435734	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000504615	ENST00000454903	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000504615	ENST00000535103	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000504615	ENST00000603181	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000504615	ENST00000603449	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000504615	ENST00000603524	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000504615	ENST00000604255	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000504615	ENST00000604404	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000504615	ENST00000604621	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000504615	ENST00000604804	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000504615	ENST00000605550	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000504615	ENST00000605552	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000504615	ENST00000605677	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000599564	ENST00000344013	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000599564	ENST00000346446	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000599564	ENST00000406242	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000599564	ENST00000406988	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000599564	ENST00000435734	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000599564	ENST00000454903	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000599564	ENST00000535103	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000599564	ENST00000603181	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000599564	ENST00000603449	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000599564	ENST00000603524	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000599564	ENST00000604255	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000599564	ENST00000604404	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000599564	ENST00000604621	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000599564	ENST00000604804	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000599564	ENST00000605550	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000599564	ENST00000605552	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
5CDS-intron	ENST00000599564	ENST00000605677	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000424536	ENST00000344013	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000424536	ENST00000346446	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000424536	ENST00000406242	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000424536	ENST00000406988	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000424536	ENST00000435734	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000424536	ENST00000454903	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000424536	ENST00000535103	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000424536	ENST00000603181	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000424536	ENST00000603449	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000424536	ENST00000603524	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000424536	ENST00000604255	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000424536	ENST00000604404	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000424536	ENST00000604621	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000424536	ENST00000604804	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000424536	ENST00000605550	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000424536	ENST00000605552	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000424536	ENST00000605677	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000598073	ENST00000344013	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000598073	ENST00000346446	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000598073	ENST00000406242	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000598073	ENST00000406988	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000598073	ENST00000435734	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000598073	ENST00000454903	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000598073	ENST00000535103	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000598073	ENST00000603181	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000598073	ENST00000603449	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000598073	ENST00000603524	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000598073	ENST00000604255	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000598073	ENST00000604404	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000598073	ENST00000604621	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000598073	ENST00000604804	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000598073	ENST00000605550	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000598073	ENST00000605552	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+
intron-intron	ENST00000598073	ENST00000605677	GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for GRAMD1A-FXYD3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+	0.00048926	0.99951077
GRAMD1A	chr19	35505291	+	FXYD3	chr19	35613668	+	0.00048926	0.99951077

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GRAMD1A-FXYD3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:35505291/:35613668)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GRAMD1A Q96CP6	FXYD3 Q14802
FUNCTION: Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192). {ECO:0000250\|UniProtKB:Q8VEF1, ECO:0000269\|PubMed:31222192}.	FUNCTION: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell (PubMed:17077088). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (PubMed:21454534). Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes (PubMed:7836447). {ECO:0000269\|PubMed:17077088, ECO:0000269\|PubMed:21454534, ECO:0000269\|PubMed:7836447}.; FUNCTION: [Isoform 1]: Decreases the apparent K+ and Na+ affinity of the sodium/potassium-transporting ATPase over a large range of membrane potentials. {ECO:0000269\|PubMed:17077088}.; FUNCTION: [Isoform 2]: Decreases the apparent K+ affinity of the sodium/potassium-transporting ATPase only at slightly negative and positive membrane potentials and increases the apparent Na+ affinity over a large range of membrane potentials. {ECO:0000269\|PubMed:17077088}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for GRAMD1A-FXYD3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GRAMD1A-FXYD3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for GRAMD1A-FXYD3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for GRAMD1A-FXYD3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source