Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GRAMD1A-RAB3IP (FusionGDB2 ID:34577)

Fusion Gene Summary for GRAMD1A-RAB3IP

Fusion gene summary

Fusion gene information	Fusion gene name: GRAMD1A-RAB3IP
	Fusion gene ID: 34577
		Hgene	Tgene
	Gene symbol	GRAMD1A	RAB3IP
	Gene ID	57655	117177
	Gene name	GRAM domain containing 1A	RAB3A interacting protein
	Synonyms	KIAA1533	RABIN3\|RABIN8
	Cytomap	19q13.11	12q15
	Type of gene	protein-coding	protein-coding
	Description	protein Aster-AGRAM domain-containing protein 1A	rab-3A-interacting proteinSSX2 interacting proteinrab3A-interacting proteinrabin-3
	Modification date	20200313	20200327
	UniProtAcc	Q96CP6	.
	Ensembl transtripts involved in fusion gene	ENST00000317991, ENST00000411896, ENST00000424536, ENST00000504615, ENST00000598073, ENST00000599564,	ENST00000325555, ENST00000362025, ENST00000378815, ENST00000483530, ENST00000550536, ENST00000550847, ENST00000551641, ENST00000553099, ENST00000247833,
Fusion gene scores	* DoF score	5 X 3 X 5=75	20 X 17 X 10=3400
	# samples	6	29
	** MAII score	log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(29/3400*10)=-3.55140994101013 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GRAMD1A [Title/Abstract] AND RAB3IP [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GRAMD1A(35491390)-RAB3IP(70193988), # samples:1 GRAMD1A(35491390)-RAB3IP(70193989), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	RAB3IP	GO:0006612	protein targeting to membrane	23382462

Fusion gene breakpoints across GRAMD1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RAB3IP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-DX-A7EI-01A	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
ChimerDB4	SARC	TCGA-DX-A7EI	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+

Top

Fusion Gene ORF analysis for GRAMD1A-RAB3IP

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000317991	ENST00000325555	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5CDS-intron	ENST00000317991	ENST00000325555	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
5CDS-intron	ENST00000317991	ENST00000362025	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5CDS-intron	ENST00000317991	ENST00000362025	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
5CDS-intron	ENST00000317991	ENST00000378815	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5CDS-intron	ENST00000317991	ENST00000378815	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
5CDS-intron	ENST00000317991	ENST00000483530	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5CDS-intron	ENST00000317991	ENST00000483530	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
5CDS-intron	ENST00000317991	ENST00000550536	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5CDS-intron	ENST00000317991	ENST00000550536	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
5CDS-intron	ENST00000317991	ENST00000550847	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5CDS-intron	ENST00000317991	ENST00000550847	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
5CDS-intron	ENST00000317991	ENST00000551641	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5CDS-intron	ENST00000317991	ENST00000551641	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
5CDS-intron	ENST00000317991	ENST00000553099	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5CDS-intron	ENST00000317991	ENST00000553099	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
5CDS-intron	ENST00000411896	ENST00000325555	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5CDS-intron	ENST00000411896	ENST00000325555	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
5CDS-intron	ENST00000411896	ENST00000362025	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5CDS-intron	ENST00000411896	ENST00000362025	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
5CDS-intron	ENST00000411896	ENST00000378815	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5CDS-intron	ENST00000411896	ENST00000378815	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
5CDS-intron	ENST00000411896	ENST00000483530	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5CDS-intron	ENST00000411896	ENST00000483530	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
5CDS-intron	ENST00000411896	ENST00000550536	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5CDS-intron	ENST00000411896	ENST00000550536	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
5CDS-intron	ENST00000411896	ENST00000550847	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5CDS-intron	ENST00000411896	ENST00000550847	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
5CDS-intron	ENST00000411896	ENST00000551641	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5CDS-intron	ENST00000411896	ENST00000551641	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
5CDS-intron	ENST00000411896	ENST00000553099	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5CDS-intron	ENST00000411896	ENST00000553099	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
5CDS-intron	ENST00000424536	ENST00000325555	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5CDS-intron	ENST00000424536	ENST00000325555	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
5CDS-intron	ENST00000424536	ENST00000362025	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5CDS-intron	ENST00000424536	ENST00000362025	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
5CDS-intron	ENST00000424536	ENST00000378815	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5CDS-intron	ENST00000424536	ENST00000378815	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
5CDS-intron	ENST00000424536	ENST00000483530	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5CDS-intron	ENST00000424536	ENST00000483530	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
5CDS-intron	ENST00000424536	ENST00000550536	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5CDS-intron	ENST00000424536	ENST00000550536	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
5CDS-intron	ENST00000424536	ENST00000550847	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5CDS-intron	ENST00000424536	ENST00000550847	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
5CDS-intron	ENST00000424536	ENST00000551641	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5CDS-intron	ENST00000424536	ENST00000551641	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
5CDS-intron	ENST00000424536	ENST00000553099	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5CDS-intron	ENST00000424536	ENST00000553099	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
5UTR-3CDS	ENST00000504615	ENST00000247833	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5UTR-3CDS	ENST00000504615	ENST00000247833	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
5UTR-intron	ENST00000504615	ENST00000325555	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5UTR-intron	ENST00000504615	ENST00000325555	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
5UTR-intron	ENST00000504615	ENST00000362025	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5UTR-intron	ENST00000504615	ENST00000362025	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
5UTR-intron	ENST00000504615	ENST00000378815	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5UTR-intron	ENST00000504615	ENST00000378815	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
5UTR-intron	ENST00000504615	ENST00000483530	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5UTR-intron	ENST00000504615	ENST00000483530	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
5UTR-intron	ENST00000504615	ENST00000550536	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5UTR-intron	ENST00000504615	ENST00000550536	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
5UTR-intron	ENST00000504615	ENST00000550847	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5UTR-intron	ENST00000504615	ENST00000550847	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
5UTR-intron	ENST00000504615	ENST00000551641	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5UTR-intron	ENST00000504615	ENST00000551641	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
5UTR-intron	ENST00000504615	ENST00000553099	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
5UTR-intron	ENST00000504615	ENST00000553099	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
Frame-shift	ENST00000317991	ENST00000247833	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
Frame-shift	ENST00000317991	ENST00000247833	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
Frame-shift	ENST00000411896	ENST00000247833	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
Frame-shift	ENST00000411896	ENST00000247833	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
Frame-shift	ENST00000424536	ENST00000247833	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
Frame-shift	ENST00000424536	ENST00000247833	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
intron-3CDS	ENST00000598073	ENST00000247833	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
intron-3CDS	ENST00000598073	ENST00000247833	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
intron-3CDS	ENST00000599564	ENST00000247833	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
intron-3CDS	ENST00000599564	ENST00000247833	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
intron-intron	ENST00000598073	ENST00000325555	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
intron-intron	ENST00000598073	ENST00000325555	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
intron-intron	ENST00000598073	ENST00000362025	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
intron-intron	ENST00000598073	ENST00000362025	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
intron-intron	ENST00000598073	ENST00000378815	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
intron-intron	ENST00000598073	ENST00000378815	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
intron-intron	ENST00000598073	ENST00000483530	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
intron-intron	ENST00000598073	ENST00000483530	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
intron-intron	ENST00000598073	ENST00000550536	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
intron-intron	ENST00000598073	ENST00000550536	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
intron-intron	ENST00000598073	ENST00000550847	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
intron-intron	ENST00000598073	ENST00000550847	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
intron-intron	ENST00000598073	ENST00000551641	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
intron-intron	ENST00000598073	ENST00000551641	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
intron-intron	ENST00000598073	ENST00000553099	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
intron-intron	ENST00000598073	ENST00000553099	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
intron-intron	ENST00000599564	ENST00000325555	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
intron-intron	ENST00000599564	ENST00000325555	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
intron-intron	ENST00000599564	ENST00000362025	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
intron-intron	ENST00000599564	ENST00000362025	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
intron-intron	ENST00000599564	ENST00000378815	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
intron-intron	ENST00000599564	ENST00000378815	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
intron-intron	ENST00000599564	ENST00000483530	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
intron-intron	ENST00000599564	ENST00000483530	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
intron-intron	ENST00000599564	ENST00000550536	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
intron-intron	ENST00000599564	ENST00000550536	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
intron-intron	ENST00000599564	ENST00000550847	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
intron-intron	ENST00000599564	ENST00000550847	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
intron-intron	ENST00000599564	ENST00000551641	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
intron-intron	ENST00000599564	ENST00000551641	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+
intron-intron	ENST00000599564	ENST00000553099	GRAMD1A	chr19	35491390	-	RAB3IP	chr12	70193989	+
intron-intron	ENST00000599564	ENST00000553099	GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for GRAMD1A-RAB3IP

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+	7.17E-05	0.99992824
GRAMD1A	chr19	35491390	+	RAB3IP	chr12	70193988	+	7.17E-05	0.99992824

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for GRAMD1A-RAB3IP

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:35491390/:70193988)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GRAMD1A Q96CP6	.
FUNCTION: Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome (PubMed:31222192). This function in autophagy requires its cholesterol-transfer activity (PubMed:31222192). {ECO:0000250\|UniProtKB:Q8VEF1, ECO:0000269\|PubMed:31222192}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Gene Sequence for GRAMD1A-RAB3IP

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for GRAMD1A-RAB3IP

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GRAMD1A-RAB3IP

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for GRAMD1A-RAB3IP

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source