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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:GRB10-CSTF3 (FusionGDB2 ID:34618)

Fusion Gene Summary for GRB10-CSTF3

check button Fusion gene summary
Fusion gene informationFusion gene name: GRB10-CSTF3
Fusion gene ID: 34618
HgeneTgene
Gene symbol

GRB10

CSTF3

Gene ID

2887

1479

Gene namegrowth factor receptor bound protein 10cleavage stimulation factor subunit 3
SynonymsGRB-IR|Grb-10|IRBP|MEG1|RSSCSTF-77
Cytomap

7p12.1

11p13

Type of geneprotein-codingprotein-coding
Descriptiongrowth factor receptor-bound protein 10GRB10 adapter proteinGRB10 adaptor proteininsulin receptor-binding protein Grb-IRmaternally expressed gene 1cleavage stimulation factor subunit 3CF-1 77 kDa subunitCSTF 77 kDa subunitcleavage stimulation factor 77 kDa subunitcleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDcleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
Modification date2020032720200313
UniProtAcc

Q13322

Q12996

Ensembl transtripts involved in fusion geneENST00000357271, ENST00000398812, 
ENST00000401949, ENST00000403097, 
ENST00000439599, ENST00000335866, 
ENST00000398810, ENST00000402497, 
ENST00000406641, ENST00000407526, 
ENST00000402578, ENST00000483819, 
ENST00000431742, ENST00000438862, 
ENST00000524827, ENST00000526480, 
ENST00000323959, 
Fusion gene scores* DoF score13 X 10 X 8=10407 X 4 X 6=168
# samples 168
** MAII scorelog2(16/1040*10)=-2.70043971814109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GRB10 [Title/Abstract] AND CSTF3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGRB10(50771518)-CSTF3(33108687), # samples:3
Anticipated loss of major functional domain due to fusion event.GRB10-CSTF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGRB10

GO:0030178

negative regulation of Wnt signaling pathway

17376403

HgeneGRB10

GO:0030949

positive regulation of vascular endothelial growth factor receptor signaling pathway

15060076


check buttonFusion gene breakpoints across GRB10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CSTF3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-61-1917-01AGRB10chr7

50771518

-CSTF3chr11

33108687

-
ChimerDB4OVTCGA-61-1917GRB10chr7

50771517

-CSTF3chr11

33108687

-


Top

Fusion Gene ORF analysis for GRB10-CSTF3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000357271ENST00000431742GRB10chr7

50771518

-CSTF3chr11

33108687

-
5CDS-intronENST00000357271ENST00000431742GRB10chr7

50771517

-CSTF3chr11

33108687

-
5CDS-intronENST00000357271ENST00000438862GRB10chr7

50771518

-CSTF3chr11

33108687

-
5CDS-intronENST00000357271ENST00000438862GRB10chr7

50771517

-CSTF3chr11

33108687

-
5CDS-intronENST00000357271ENST00000524827GRB10chr7

50771518

-CSTF3chr11

33108687

-
5CDS-intronENST00000357271ENST00000524827GRB10chr7

50771517

-CSTF3chr11

33108687

-
5CDS-intronENST00000357271ENST00000526480GRB10chr7

50771518

-CSTF3chr11

33108687

-
5CDS-intronENST00000357271ENST00000526480GRB10chr7

50771517

-CSTF3chr11

33108687

-
5CDS-intronENST00000398812ENST00000431742GRB10chr7

50771518

-CSTF3chr11

33108687

-
5CDS-intronENST00000398812ENST00000431742GRB10chr7

50771517

-CSTF3chr11

33108687

-
5CDS-intronENST00000398812ENST00000438862GRB10chr7

50771518

-CSTF3chr11

33108687

-
5CDS-intronENST00000398812ENST00000438862GRB10chr7

50771517

-CSTF3chr11

33108687

-
5CDS-intronENST00000398812ENST00000524827GRB10chr7

50771518

-CSTF3chr11

33108687

-
5CDS-intronENST00000398812ENST00000524827GRB10chr7

50771517

-CSTF3chr11

33108687

-
5CDS-intronENST00000398812ENST00000526480GRB10chr7

50771518

-CSTF3chr11

33108687

-
5CDS-intronENST00000398812ENST00000526480GRB10chr7

50771517

-CSTF3chr11

33108687

-
5CDS-intronENST00000401949ENST00000431742GRB10chr7

50771518

-CSTF3chr11

33108687

-
5CDS-intronENST00000401949ENST00000431742GRB10chr7

50771517

-CSTF3chr11

33108687

-
5CDS-intronENST00000401949ENST00000438862GRB10chr7

50771518

-CSTF3chr11

33108687

-
5CDS-intronENST00000401949ENST00000438862GRB10chr7

50771517

-CSTF3chr11

33108687

-
5CDS-intronENST00000401949ENST00000524827GRB10chr7

50771518

-CSTF3chr11

33108687

-
5CDS-intronENST00000401949ENST00000524827GRB10chr7

50771517

-CSTF3chr11

33108687

-
5CDS-intronENST00000401949ENST00000526480GRB10chr7

50771518

-CSTF3chr11

33108687

-
5CDS-intronENST00000401949ENST00000526480GRB10chr7

50771517

-CSTF3chr11

33108687

-
5CDS-intronENST00000403097ENST00000431742GRB10chr7

50771518

-CSTF3chr11

33108687

-
5CDS-intronENST00000403097ENST00000431742GRB10chr7

50771517

-CSTF3chr11

33108687

-
5CDS-intronENST00000403097ENST00000438862GRB10chr7

50771518

-CSTF3chr11

33108687

-
5CDS-intronENST00000403097ENST00000438862GRB10chr7

50771517

-CSTF3chr11

33108687

-
5CDS-intronENST00000403097ENST00000524827GRB10chr7

50771518

-CSTF3chr11

33108687

-
5CDS-intronENST00000403097ENST00000524827GRB10chr7

50771517

-CSTF3chr11

33108687

-
5CDS-intronENST00000403097ENST00000526480GRB10chr7

50771518

-CSTF3chr11

33108687

-
5CDS-intronENST00000403097ENST00000526480GRB10chr7

50771517

-CSTF3chr11

33108687

-
5CDS-intronENST00000439599ENST00000431742GRB10chr7

50771518

-CSTF3chr11

33108687

-
5CDS-intronENST00000439599ENST00000431742GRB10chr7

50771517

-CSTF3chr11

33108687

-
5CDS-intronENST00000439599ENST00000438862GRB10chr7

50771518

-CSTF3chr11

33108687

-
5CDS-intronENST00000439599ENST00000438862GRB10chr7

50771517

-CSTF3chr11

33108687

-
5CDS-intronENST00000439599ENST00000524827GRB10chr7

50771518

-CSTF3chr11

33108687

-
5CDS-intronENST00000439599ENST00000524827GRB10chr7

50771517

-CSTF3chr11

33108687

-
5CDS-intronENST00000439599ENST00000526480GRB10chr7

50771518

-CSTF3chr11

33108687

-
5CDS-intronENST00000439599ENST00000526480GRB10chr7

50771517

-CSTF3chr11

33108687

-
5UTR-3CDSENST00000335866ENST00000323959GRB10chr7

50771518

-CSTF3chr11

33108687

-
5UTR-3CDSENST00000335866ENST00000323959GRB10chr7

50771517

-CSTF3chr11

33108687

-
5UTR-3CDSENST00000398810ENST00000323959GRB10chr7

50771518

-CSTF3chr11

33108687

-
5UTR-3CDSENST00000398810ENST00000323959GRB10chr7

50771517

-CSTF3chr11

33108687

-
5UTR-3CDSENST00000402497ENST00000323959GRB10chr7

50771518

-CSTF3chr11

33108687

-
5UTR-3CDSENST00000402497ENST00000323959GRB10chr7

50771517

-CSTF3chr11

33108687

-
5UTR-3CDSENST00000406641ENST00000323959GRB10chr7

50771518

-CSTF3chr11

33108687

-
5UTR-3CDSENST00000406641ENST00000323959GRB10chr7

50771517

-CSTF3chr11

33108687

-
5UTR-3CDSENST00000407526ENST00000323959GRB10chr7

50771518

-CSTF3chr11

33108687

-
5UTR-3CDSENST00000407526ENST00000323959GRB10chr7

50771517

-CSTF3chr11

33108687

-
5UTR-intronENST00000335866ENST00000431742GRB10chr7

50771518

-CSTF3chr11

33108687

-
5UTR-intronENST00000335866ENST00000431742GRB10chr7

50771517

-CSTF3chr11

33108687

-
5UTR-intronENST00000335866ENST00000438862GRB10chr7

50771518

-CSTF3chr11

33108687

-
5UTR-intronENST00000335866ENST00000438862GRB10chr7

50771517

-CSTF3chr11

33108687

-
5UTR-intronENST00000335866ENST00000524827GRB10chr7

50771518

-CSTF3chr11

33108687

-
5UTR-intronENST00000335866ENST00000524827GRB10chr7

50771517

-CSTF3chr11

33108687

-
5UTR-intronENST00000335866ENST00000526480GRB10chr7

50771518

-CSTF3chr11

33108687

-
5UTR-intronENST00000335866ENST00000526480GRB10chr7

50771517

-CSTF3chr11

33108687

-
5UTR-intronENST00000398810ENST00000431742GRB10chr7

50771518

-CSTF3chr11

33108687

-
5UTR-intronENST00000398810ENST00000431742GRB10chr7

50771517

-CSTF3chr11

33108687

-
5UTR-intronENST00000398810ENST00000438862GRB10chr7

50771518

-CSTF3chr11

33108687

-
5UTR-intronENST00000398810ENST00000438862GRB10chr7

50771517

-CSTF3chr11

33108687

-
5UTR-intronENST00000398810ENST00000524827GRB10chr7

50771518

-CSTF3chr11

33108687

-
5UTR-intronENST00000398810ENST00000524827GRB10chr7

50771517

-CSTF3chr11

33108687

-
5UTR-intronENST00000398810ENST00000526480GRB10chr7

50771518

-CSTF3chr11

33108687

-
5UTR-intronENST00000398810ENST00000526480GRB10chr7

50771517

-CSTF3chr11

33108687

-
5UTR-intronENST00000402497ENST00000431742GRB10chr7

50771518

-CSTF3chr11

33108687

-
5UTR-intronENST00000402497ENST00000431742GRB10chr7

50771517

-CSTF3chr11

33108687

-
5UTR-intronENST00000402497ENST00000438862GRB10chr7

50771518

-CSTF3chr11

33108687

-
5UTR-intronENST00000402497ENST00000438862GRB10chr7

50771517

-CSTF3chr11

33108687

-
5UTR-intronENST00000402497ENST00000524827GRB10chr7

50771518

-CSTF3chr11

33108687

-
5UTR-intronENST00000402497ENST00000524827GRB10chr7

50771517

-CSTF3chr11

33108687

-
5UTR-intronENST00000402497ENST00000526480GRB10chr7

50771518

-CSTF3chr11

33108687

-
5UTR-intronENST00000402497ENST00000526480GRB10chr7

50771517

-CSTF3chr11

33108687

-
5UTR-intronENST00000406641ENST00000431742GRB10chr7

50771518

-CSTF3chr11

33108687

-
5UTR-intronENST00000406641ENST00000431742GRB10chr7

50771517

-CSTF3chr11

33108687

-
5UTR-intronENST00000406641ENST00000438862GRB10chr7

50771518

-CSTF3chr11

33108687

-
5UTR-intronENST00000406641ENST00000438862GRB10chr7

50771517

-CSTF3chr11

33108687

-
5UTR-intronENST00000406641ENST00000524827GRB10chr7

50771518

-CSTF3chr11

33108687

-
5UTR-intronENST00000406641ENST00000524827GRB10chr7

50771517

-CSTF3chr11

33108687

-
5UTR-intronENST00000406641ENST00000526480GRB10chr7

50771518

-CSTF3chr11

33108687

-
5UTR-intronENST00000406641ENST00000526480GRB10chr7

50771517

-CSTF3chr11

33108687

-
5UTR-intronENST00000407526ENST00000431742GRB10chr7

50771518

-CSTF3chr11

33108687

-
5UTR-intronENST00000407526ENST00000431742GRB10chr7

50771517

-CSTF3chr11

33108687

-
5UTR-intronENST00000407526ENST00000438862GRB10chr7

50771518

-CSTF3chr11

33108687

-
5UTR-intronENST00000407526ENST00000438862GRB10chr7

50771517

-CSTF3chr11

33108687

-
5UTR-intronENST00000407526ENST00000524827GRB10chr7

50771518

-CSTF3chr11

33108687

-
5UTR-intronENST00000407526ENST00000524827GRB10chr7

50771517

-CSTF3chr11

33108687

-
5UTR-intronENST00000407526ENST00000526480GRB10chr7

50771518

-CSTF3chr11

33108687

-
5UTR-intronENST00000407526ENST00000526480GRB10chr7

50771517

-CSTF3chr11

33108687

-
Frame-shiftENST00000357271ENST00000323959GRB10chr7

50771518

-CSTF3chr11

33108687

-
Frame-shiftENST00000357271ENST00000323959GRB10chr7

50771517

-CSTF3chr11

33108687

-
Frame-shiftENST00000398812ENST00000323959GRB10chr7

50771518

-CSTF3chr11

33108687

-
Frame-shiftENST00000398812ENST00000323959GRB10chr7

50771517

-CSTF3chr11

33108687

-
Frame-shiftENST00000401949ENST00000323959GRB10chr7

50771518

-CSTF3chr11

33108687

-
Frame-shiftENST00000401949ENST00000323959GRB10chr7

50771517

-CSTF3chr11

33108687

-
Frame-shiftENST00000403097ENST00000323959GRB10chr7

50771518

-CSTF3chr11

33108687

-
Frame-shiftENST00000403097ENST00000323959GRB10chr7

50771517

-CSTF3chr11

33108687

-
Frame-shiftENST00000439599ENST00000323959GRB10chr7

50771518

-CSTF3chr11

33108687

-
Frame-shiftENST00000439599ENST00000323959GRB10chr7

50771517

-CSTF3chr11

33108687

-
intron-3CDSENST00000402578ENST00000323959GRB10chr7

50771518

-CSTF3chr11

33108687

-
intron-3CDSENST00000402578ENST00000323959GRB10chr7

50771517

-CSTF3chr11

33108687

-
intron-3CDSENST00000483819ENST00000323959GRB10chr7

50771518

-CSTF3chr11

33108687

-
intron-3CDSENST00000483819ENST00000323959GRB10chr7

50771517

-CSTF3chr11

33108687

-
intron-intronENST00000402578ENST00000431742GRB10chr7

50771518

-CSTF3chr11

33108687

-
intron-intronENST00000402578ENST00000431742GRB10chr7

50771517

-CSTF3chr11

33108687

-
intron-intronENST00000402578ENST00000438862GRB10chr7

50771518

-CSTF3chr11

33108687

-
intron-intronENST00000402578ENST00000438862GRB10chr7

50771517

-CSTF3chr11

33108687

-
intron-intronENST00000402578ENST00000524827GRB10chr7

50771518

-CSTF3chr11

33108687

-
intron-intronENST00000402578ENST00000524827GRB10chr7

50771517

-CSTF3chr11

33108687

-
intron-intronENST00000402578ENST00000526480GRB10chr7

50771518

-CSTF3chr11

33108687

-
intron-intronENST00000402578ENST00000526480GRB10chr7

50771517

-CSTF3chr11

33108687

-
intron-intronENST00000483819ENST00000431742GRB10chr7

50771518

-CSTF3chr11

33108687

-
intron-intronENST00000483819ENST00000431742GRB10chr7

50771517

-CSTF3chr11

33108687

-
intron-intronENST00000483819ENST00000438862GRB10chr7

50771518

-CSTF3chr11

33108687

-
intron-intronENST00000483819ENST00000438862GRB10chr7

50771517

-CSTF3chr11

33108687

-
intron-intronENST00000483819ENST00000524827GRB10chr7

50771518

-CSTF3chr11

33108687

-
intron-intronENST00000483819ENST00000524827GRB10chr7

50771517

-CSTF3chr11

33108687

-
intron-intronENST00000483819ENST00000526480GRB10chr7

50771518

-CSTF3chr11

33108687

-
intron-intronENST00000483819ENST00000526480GRB10chr7

50771517

-CSTF3chr11

33108687

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for GRB10-CSTF3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GRB10-CSTF3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:50771518/:33108687)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GRB10

Q13322

CSTF3

Q12996

FUNCTION: Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. {ECO:0000269|PubMed:12493740, ECO:0000269|PubMed:15060076, ECO:0000269|PubMed:16434550, ECO:0000269|PubMed:17376403}.FUNCTION: One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for GRB10-CSTF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GRB10-CSTF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GRB10-CSTF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GRB10-CSTF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource