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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
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Fusion gene:GRB10-SCIN (FusionGDB2 ID:34626)

Fusion Gene Summary for GRB10-SCIN

Fusion gene summary

Fusion gene information	Fusion gene name: GRB10-SCIN
	Fusion gene ID: 34626
		Hgene	Tgene
	Gene symbol	GRB10	SCIN
	Gene ID	2887	85477
	Gene name	growth factor receptor bound protein 10	scinderin
	Synonyms	GRB-IR\|Grb-10\|IRBP\|MEG1\|RSS	-
	Cytomap	7p12.1	7p21.3
	Type of gene	protein-coding	protein-coding
	Description	growth factor receptor-bound protein 10GRB10 adapter proteinGRB10 adaptor proteininsulin receptor-binding protein Grb-IRmaternally expressed gene 1	adseverin
	Modification date	20200327	20200313
	UniProtAcc	Q13322	.
	Ensembl transtripts involved in fusion gene	ENST00000335866, ENST00000357271, ENST00000398810, ENST00000398812, ENST00000401949, ENST00000402497, ENST00000402578, ENST00000403097, ENST00000406641, ENST00000407526, ENST00000439599, ENST00000483819,	ENST00000473722, ENST00000445618, ENST00000519209, ENST00000297029,
Fusion gene scores	* DoF score	13 X 10 X 8=1040	5 X 6 X 5=150
	# samples	16	6
	** MAII score	log2(16/1040*10)=-2.70043971814109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GRB10 [Title/Abstract] AND SCIN [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GRB10(50737419)-SCIN(12662426), # samples:2
Anticipated loss of major functional domain due to fusion event.	GRB10-SCIN seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GRB10	GO:0030178	negative regulation of Wnt signaling pathway	17376403
Hgene	GRB10	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	15060076

Fusion gene breakpoints across GRB10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SCIN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-24-1557-01A	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+

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Fusion Gene ORF analysis for GRB10-SCIN

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000335866	ENST00000473722	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
5CDS-3UTR	ENST00000357271	ENST00000473722	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
5CDS-3UTR	ENST00000398810	ENST00000473722	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
5CDS-3UTR	ENST00000398812	ENST00000473722	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
5CDS-3UTR	ENST00000401949	ENST00000473722	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
5CDS-3UTR	ENST00000402497	ENST00000473722	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
5CDS-3UTR	ENST00000402578	ENST00000473722	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
5CDS-3UTR	ENST00000403097	ENST00000473722	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
5CDS-3UTR	ENST00000406641	ENST00000473722	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
5CDS-3UTR	ENST00000407526	ENST00000473722	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
5CDS-3UTR	ENST00000439599	ENST00000473722	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
5CDS-5UTR	ENST00000335866	ENST00000445618	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
5CDS-5UTR	ENST00000335866	ENST00000519209	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
5CDS-5UTR	ENST00000357271	ENST00000445618	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
5CDS-5UTR	ENST00000357271	ENST00000519209	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
5CDS-5UTR	ENST00000398810	ENST00000445618	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
5CDS-5UTR	ENST00000398810	ENST00000519209	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
5CDS-5UTR	ENST00000398812	ENST00000445618	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
5CDS-5UTR	ENST00000398812	ENST00000519209	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
5CDS-5UTR	ENST00000401949	ENST00000445618	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
5CDS-5UTR	ENST00000401949	ENST00000519209	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
5CDS-5UTR	ENST00000402497	ENST00000445618	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
5CDS-5UTR	ENST00000402497	ENST00000519209	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
5CDS-5UTR	ENST00000402578	ENST00000445618	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
5CDS-5UTR	ENST00000402578	ENST00000519209	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
5CDS-5UTR	ENST00000403097	ENST00000445618	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
5CDS-5UTR	ENST00000403097	ENST00000519209	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
5CDS-5UTR	ENST00000406641	ENST00000445618	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
5CDS-5UTR	ENST00000406641	ENST00000519209	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
5CDS-5UTR	ENST00000407526	ENST00000445618	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
5CDS-5UTR	ENST00000407526	ENST00000519209	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
5CDS-5UTR	ENST00000439599	ENST00000445618	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
5CDS-5UTR	ENST00000439599	ENST00000519209	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
Frame-shift	ENST00000335866	ENST00000297029	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
Frame-shift	ENST00000401949	ENST00000297029	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
Frame-shift	ENST00000402497	ENST00000297029	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
Frame-shift	ENST00000403097	ENST00000297029	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
Frame-shift	ENST00000406641	ENST00000297029	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
Frame-shift	ENST00000407526	ENST00000297029	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
In-frame	ENST00000357271	ENST00000297029	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
In-frame	ENST00000398810	ENST00000297029	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
In-frame	ENST00000398812	ENST00000297029	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
In-frame	ENST00000402578	ENST00000297029	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
In-frame	ENST00000439599	ENST00000297029	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
intron-3CDS	ENST00000483819	ENST00000297029	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
intron-3UTR	ENST00000483819	ENST00000473722	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
intron-5UTR	ENST00000483819	ENST00000445618	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+
intron-5UTR	ENST00000483819	ENST00000519209	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000398810	GRB10	chr7	50737419	-	ENST00000297029	SCIN	chr7	12662426	+	2985	615	132	2096	654
ENST00000439599	GRB10	chr7	50737419	-	ENST00000297029	SCIN	chr7	12662426	+	2856	486	0	1967	655
ENST00000398812	GRB10	chr7	50737419	-	ENST00000297029	SCIN	chr7	12662426	+	2905	535	31	2016	661
ENST00000402578	GRB10	chr7	50737419	-	ENST00000297029	SCIN	chr7	12662426	+	2965	595	244	2076	610
ENST00000357271	GRB10	chr7	50737419	-	ENST00000297029	SCIN	chr7	12662426	+	2905	535	31	2016	661

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000398810	ENST00000297029	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+	0.00123156	0.9987684
ENST00000439599	ENST00000297029	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+	0.000930468	0.9990695
ENST00000398812	ENST00000297029	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+	0.000536722	0.99946326
ENST00000402578	ENST00000297029	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+	0.001049041	0.99895096
ENST00000357271	ENST00000297029	GRB10	chr7	50737419	-	SCIN	chr7	12662426	+	0.000536722	0.99946326

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Fusion Genomic Features for GRB10-SCIN

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
GRB10	chr7	50737418	-	SCIN	chr7	12662425	+	0.17624581	0.82375413
GRB10	chr7	50737418	-	SCIN	chr7	12662425	+	0.17624581	0.82375413

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GRB10-SCIN

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:50737419/chr7:12662426)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GRB10 Q13322	.
FUNCTION: Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. {ECO:0000269\|PubMed:12493740, ECO:0000269\|PubMed:15060076, ECO:0000269\|PubMed:16434550, ECO:0000269\|PubMed:17376403}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SCIN

chr7:50737419

chr7:12662426

ENST00000297029

364_715

222

716.0

Region

Note=Ca(2+)-dependent actin binding

Tgene

SCIN

chr7:50737419

chr7:12662426

ENST00000445618

112_119

469.0

Region

Polyphosphoinositide binding

Tgene

SCIN

chr7:50737419

chr7:12662426

ENST00000445618

138_146

469.0

Region

Polyphosphoinositide binding

Tgene

SCIN

chr7:50737419

chr7:12662426

ENST00000445618

1_363

469.0

Region

Actin-severing

Tgene

SCIN

chr7:50737419

chr7:12662426

ENST00000445618

364_715

469.0

Region

Note=Ca(2+)-dependent actin binding

Tgene

SCIN

chr7:50737419

chr7:12662426

ENST00000519209

112_119

469.0

Region

Polyphosphoinositide binding

Tgene

SCIN

chr7:50737419

chr7:12662426

ENST00000519209

138_146

469.0

Region

Polyphosphoinositide binding

Tgene

SCIN

chr7:50737419

chr7:12662426

ENST00000519209

1_363

469.0

Region

Actin-severing

Tgene

SCIN

chr7:50737419

chr7:12662426

ENST00000519209

364_715

469.0

Region

Note=Ca(2+)-dependent actin binding

Tgene

SCIN

chr7:50737419

chr7:12662426

ENST00000297029

265_307

222

716.0

Repeat

Note=Gelsolin-like 3

Tgene

SCIN

chr7:50737419

chr7:12662426

ENST00000297029

398_451

222

716.0

Repeat

Note=Gelsolin-like 4

Tgene

SCIN

chr7:50737419

chr7:12662426

ENST00000297029

523_564

222

716.0

Repeat

Note=Gelsolin-like 5

Tgene

SCIN

chr7:50737419

chr7:12662426

ENST00000297029

626_668

222

716.0

Repeat

Note=Gelsolin-like 6

Tgene

SCIN

chr7:50737419

chr7:12662426

ENST00000445618

148_188

469.0

Repeat

Note=Gelsolin-like 2

Tgene

SCIN

chr7:50737419

chr7:12662426

ENST00000445618

265_307

469.0

Repeat

Note=Gelsolin-like 3

Tgene

SCIN

chr7:50737419

chr7:12662426

ENST00000445618

27_76

469.0

Repeat

Note=Gelsolin-like 1

Tgene

SCIN

chr7:50737419

chr7:12662426

ENST00000445618

398_451

469.0

Repeat

Note=Gelsolin-like 4

Tgene

SCIN

chr7:50737419

chr7:12662426

ENST00000445618

523_564

469.0

Repeat

Note=Gelsolin-like 5

Tgene

SCIN

chr7:50737419

chr7:12662426

ENST00000445618

626_668

469.0

Repeat

Note=Gelsolin-like 6

Tgene

SCIN

chr7:50737419

chr7:12662426

ENST00000519209

148_188

469.0

Repeat

Note=Gelsolin-like 2

Tgene

SCIN

chr7:50737419

chr7:12662426

ENST00000519209

265_307

469.0

Repeat

Note=Gelsolin-like 3

Tgene

SCIN

chr7:50737419

chr7:12662426

ENST00000519209

27_76

469.0

Repeat

Note=Gelsolin-like 1

Tgene

SCIN

chr7:50737419

chr7:12662426

ENST00000519209

398_451

469.0

Repeat

Note=Gelsolin-like 4

Tgene

SCIN

chr7:50737419

chr7:12662426

ENST00000519209

523_564

469.0

Repeat

Note=Gelsolin-like 5

Tgene

SCIN

chr7:50737419

chr7:12662426

ENST00000519209

626_668

469.0

Repeat

Note=Gelsolin-like 6

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000335866

166_250

110

537.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000335866

290_399

110

537.0

Domain

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000335866

493_574

110

537.0

Domain

SH2

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000357271

166_250

168

549.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000357271

290_399

168

549.0

Domain

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000357271

493_574

168

549.0

Domain

SH2

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000398810

166_250

110

537.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000398810

290_399

110

537.0

Domain

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000398810

493_574

110

537.0

Domain

SH2

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000398812

166_250

168

595.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000398812

290_399

168

595.0

Domain

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000398812

493_574

168

595.0

Domain

SH2

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000401949

166_250

168

595.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000401949

290_399

168

595.0

Domain

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000401949

493_574

168

595.0

Domain

SH2

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000402497

166_250

110

537.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000402497

290_399

110

537.0

Domain

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000402497

493_574

110

537.0

Domain

SH2

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000402578

166_250

110

537.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000402578

290_399

110

537.0

Domain

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000402578

493_574

110

537.0

Domain

SH2

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000403097

166_250

162

589.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000403097

290_399

162

589.0

Domain

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000403097

493_574

162

589.0

Domain

SH2

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000406641

166_250

110

537.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000406641

290_399

110

537.0

Domain

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000406641

493_574

110

537.0

Domain

SH2

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000407526

166_250

110

537.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000407526

290_399

110

537.0

Domain

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000407526

493_574

110

537.0

Domain

SH2

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000439599

166_250

162

589.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000439599

290_399

162

589.0

Domain

Hgene

GRB10

chr7:50737419

chr7:12662426

ENST00000439599

493_574

162

589.0

Domain

SH2

Tgene

SCIN

chr7:50737419

chr7:12662426

ENST00000297029

112_119

222

716.0

Region

Polyphosphoinositide binding

Tgene

SCIN

chr7:50737419

chr7:12662426

ENST00000297029

138_146

222

716.0

Region

Polyphosphoinositide binding

Tgene

SCIN

chr7:50737419

chr7:12662426

ENST00000297029

1_363

222

716.0

Region

Actin-severing

Tgene

SCIN

chr7:50737419

chr7:12662426

ENST00000297029

148_188

222

716.0

Repeat

Note=Gelsolin-like 2

Tgene

SCIN

chr7:50737419

chr7:12662426

ENST00000297029

27_76

222

716.0

Repeat

Note=Gelsolin-like 1

Top

Fusion Gene Sequence for GRB10-SCIN

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>34626_34626_1_GRB10-SCIN_GRB10_chr7_50737419_ENST00000357271_SCIN_chr7_12662426_ENST00000297029_length(transcript)=2905nt_BP=535nt
AAATGTAATTTGAAGAAGGCAGAAGGAACCCATGGCTTTAGCCGGCTGCCCAGATTCCTTTTTGCACCATCCGTACTACCAGGACAAGGT
GGAGCAGACACCTCGCAGTCAACAAGACCCGGCAGGACCAGGACTCCCCGCACAGTCTGACCGACTTGCGAATCACCAGGAGGATGATGT
GGACCTGGAAGCCCTGGTGAACGATATGAATGCATCCCTGGAGAGCCTGTACTCGGCCTGCAGCATGCAGTCAGACACGGTGCCCCTCCT
GCAGAATGGCCAGCATGCCCGCAGCCAGCCTCGGGCTTCAGGCCCTCCTCGGTCCATCCAGCCACAGGTGTCCCCGAGGCAGAGGGTGCA
GCGCTCCCAGCCTGTGCACATCCTCGCTGTCAGGCGCCTTCAGGAGGAAGACCAGCAGTTTAGAACCTCATCTCTGCCGGCCATCCCCAA
TCCTTTTCCTGAACTCTGTGGCCCTGGGAGCCCCCCTGTGCTCACGCCGGGTTCTTTACCTCCGAGCCAGGCCGCCGCAAAGCAGGTCTT
AGGGGAAAAGCCAGAGCTTCCAGATGGAGGTGATGATGATGACATTATAGCAGACATAAGTAACAGGAAAATGGCTAAACTATACATGGT
TTCAGATGCAAGTGGCTCCATGAGAGTGACTGTGGTGGCAGAAGAAAACCCCTTCTCAATGGCAATGCTGCTGTCTGAAGAATGCTTTAT
TTTGGACCACGGGGCTGCCAAACAAATTTTCGTATGGAAAGGTAAAGATGCTAATCCCCAAGAGAGGAAGGCTGCAATGAAGACAGCTGA
AGAATTTCTACAGCAAATGAATTATTCCAAGAATACCCAAATTCAAGTTCTTCCAGAAGGAGGTGAAACACCAATCTTCAAACAGTTTTT
TAAGGACTGGAGAGATAAAGATCAGAGTGATGGCTTCGGGAAAGTTTATGTCACAGAGAAAGTGGCTCAAATAAAACAAATTCCCTTTGA
TGCCTCAAAATTACACAGTTCTCCGCAGATGGCAGCCCAGCACAATATGGTGGATGATGGTTCTGGCAAAGTGGAGATTTGGCGTGTAGA
AAACAATGGTAGGATCCAAGTTGACCAAAACTCATATGGTGAATTCTATGGTGGTGACTGCTACATCATACTCTACACCTATCCCAGAGG
ACAGATTATCTACACGTGGCAAGGAGCAAATGCCACACGAGATGAGCTGACAACATCTGCGTTCCTGACTGTTCAGTTGGATCGGTCCCT
TGGAGGACAGGCTGTGCAGATCCGAGTCTCCCAAGGCAAAGAGCCTGTTCACCTACTGAGTTTGTTCAAAGACAAACCGCTCATTATTTA
CAAGAATGGAACATCAAAGAAAGGAGGTCAGGCACCTGCTCCCCCTACACGCCTCTTTCAAGTCCGGAGAAACCTGGCATCTATCACCAG
AATTGTGGAGGTTGATGTTGATGCAAATTCACTGAATTCTAACGATGTTTTTGTCCTGAAACTGCCACAAAATAGTGGCTACATCTGGGT
AGGAAAAGGTGCTAGCCAGGAGGAGGAGAAAGGAGCAGAGTATGTAGCAAGTGTCCTAAAGTGCAAAACCTTAAGGATCCAAGAAGGCGA
GGAGCCAGAGGAGTTCTGGAATTCCCTTGGAGGGAAAAAAGACTACCAGACCTCACCACTACTGGAAACCCAGGCTGAAGACCATCCACC
TCGGCTTTACGGCTGCTCTAACAAAACTGGAAGATTTGTTATTGAAGAGATTCCAGGAGAGTTCACCCAGGATGATTTAGCTGAAGATGA
TGTCATGTTACTAGATGCTTGGGAACAGATATTTATTTGGATTGGCAAAGATGCTAATGAAGTTGAGAAAAAAGAATCTCTGAAGTCTGC
CAAAATGTACCTTGAGACAGACCCTTCTGGAAGAGACAAGAGGACACCAATTGTCATCATAAAACAGGGCCATGAGCCACCCACATTCAC
AGGCTGGTTCCTGGGCTGGGATTCCAGCAAGTGGTAAATTGGTATTTGTAAAAAGCAAACAAACATTACAAGGCAGTTATCTCATTGCTG
TTTTGGGAGAGGAACGGGAAAAGCTTTTTGCTTATTTGTCTTTTGAAAATTAAGGCTGGGCGCGGTGGCTCACACCTGTAATCCCAGCAC
TTTGAGAGGATGAGGTAGGCGGATCACTGGGGTCAGGATTTCGAGACCAGCCTGGCCAACATGGCGAAACCTCGCCTCTACTAAAAATAC
AAAAAAATTAGCTGCGCGTGGTGGTGCACGCCTGTAGTCCCTGCTACTTGGAAGGCTGAGACAGGAAAATTGCTTGAACCCAGGAGGCTG
AGGTTGCAGTGAGCCAGGATTGCGCCACCACACTCCAGCCTGGGCAACAGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAATTAACCTC
AACCAAACGCCTATTTTTTAATGCTTAGTTTTGGCTTGAAATTCTTCTTCACCTGGAGTTTTCTTACGTTAATACATTAAAATAACCTGA
AGGAAACTTTCGTTATGGGCCAATATTAGCTCTTATGGAAACTGATTTATATCTTTTTTATGACCTTTCAAAAGTAAAATACTATGCATA
ATCTAGAAAGATTTGTCAGATAGGAAATTTTATAATGCATTAGCCATTAGTCAGAGTTGTTTTTTAACATGCCAGAGAAAAAGTTGTAAT
GCCTTGGAAGTTATTCTCTTTTCTATAGATTGTGTTCAAAAGATGTGTATACTTGCAATAAGGTTTATGTTAAGGTGGCTTTAACAATTG
GTTGCTATTTTCCTTCTTTAGTCAATATGACTTTGATGTCATTAACTGCTAAGTGTTATTTTCTAAGAGGAATTTTATCTTTTTTTTAAC

>34626_34626_1_GRB10-SCIN_GRB10_chr7_50737419_ENST00000357271_SCIN_chr7_12662426_ENST00000297029_length(amino acids)=661AA_BP=167
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQVLGEKPELPDGG
DDDDIIADISNRKMAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMNYSK
NTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIKQIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQN
SYGEFYGGDCYIILYTYPRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQ
APAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSLG
GKKDYQTSPLLETQAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKKESLKSAKMYLETDPSG

--------------------------------------------------------------
>34626_34626_2_GRB10-SCIN_GRB10_chr7_50737419_ENST00000398810_SCIN_chr7_12662426_ENST00000297029_length(transcript)=2985nt_BP=615nt
CGCAACTTTGCCTCCCAGGGAACAAACATCCTCCTTCTAAGTGGTAGATGTGGGTGAGCTGACCCTGCTGGAGTCTGTCCCCTGGGCTAC
CCTCTGCTTCCCCCCATTGTGAGTGGTCCGTGAAGCACAGCGTTGACCAGACCTAAACCTGTTTGCTCCCAGGACAAGGTGGAGCAGACA
CCTCGCAGTCAACAAGACCCGGCAGGACCAGGACTCCCCGCACAGTCTGACCGACTTGCGAATCACCAGGAGGATGATGTGGACCTGGAA
GCCCTGGTGAACGATATGAATGCATCCCTGGAGAGCCTGTACTCGGCCTGCAGCATGCAGTCAGACACGGTGCCCCTCCTGCAGAATGGC
CAGCATGCCCGCAGCCAGCCTCGGGCTTCAGGCCCTCCTCGGTCCATCCAGCCACAGGTGTCCCCGAGGCAGAGGGTGCAGCGCTCCCAG
CCTGTGCACATCCTCGCTGTCAGGCGCCTTCAGGAGGAAGACCAGCAGTTTAGAACCTCATCTCTGCCGGCCATCCCCAATCCTTTTCCT
GAACTCTGTGGCCCTGGGAGCCCCCCTGTGCTCACGCCGGGTTCTTTACCTCCGAGCCAGGCCGCCGCAAAGCAGGTCTTAGGGGAAAAG
CCAGAGCTTCCAGATGGAGGTGATGATGATGACATTATAGCAGACATAAGTAACAGGAAAATGGCTAAACTATACATGGTTTCAGATGCA
AGTGGCTCCATGAGAGTGACTGTGGTGGCAGAAGAAAACCCCTTCTCAATGGCAATGCTGCTGTCTGAAGAATGCTTTATTTTGGACCAC
GGGGCTGCCAAACAAATTTTCGTATGGAAAGGTAAAGATGCTAATCCCCAAGAGAGGAAGGCTGCAATGAAGACAGCTGAAGAATTTCTA
CAGCAAATGAATTATTCCAAGAATACCCAAATTCAAGTTCTTCCAGAAGGAGGTGAAACACCAATCTTCAAACAGTTTTTTAAGGACTGG
AGAGATAAAGATCAGAGTGATGGCTTCGGGAAAGTTTATGTCACAGAGAAAGTGGCTCAAATAAAACAAATTCCCTTTGATGCCTCAAAA
TTACACAGTTCTCCGCAGATGGCAGCCCAGCACAATATGGTGGATGATGGTTCTGGCAAAGTGGAGATTTGGCGTGTAGAAAACAATGGT
AGGATCCAAGTTGACCAAAACTCATATGGTGAATTCTATGGTGGTGACTGCTACATCATACTCTACACCTATCCCAGAGGACAGATTATC
TACACGTGGCAAGGAGCAAATGCCACACGAGATGAGCTGACAACATCTGCGTTCCTGACTGTTCAGTTGGATCGGTCCCTTGGAGGACAG
GCTGTGCAGATCCGAGTCTCCCAAGGCAAAGAGCCTGTTCACCTACTGAGTTTGTTCAAAGACAAACCGCTCATTATTTACAAGAATGGA
ACATCAAAGAAAGGAGGTCAGGCACCTGCTCCCCCTACACGCCTCTTTCAAGTCCGGAGAAACCTGGCATCTATCACCAGAATTGTGGAG
GTTGATGTTGATGCAAATTCACTGAATTCTAACGATGTTTTTGTCCTGAAACTGCCACAAAATAGTGGCTACATCTGGGTAGGAAAAGGT
GCTAGCCAGGAGGAGGAGAAAGGAGCAGAGTATGTAGCAAGTGTCCTAAAGTGCAAAACCTTAAGGATCCAAGAAGGCGAGGAGCCAGAG
GAGTTCTGGAATTCCCTTGGAGGGAAAAAAGACTACCAGACCTCACCACTACTGGAAACCCAGGCTGAAGACCATCCACCTCGGCTTTAC
GGCTGCTCTAACAAAACTGGAAGATTTGTTATTGAAGAGATTCCAGGAGAGTTCACCCAGGATGATTTAGCTGAAGATGATGTCATGTTA
CTAGATGCTTGGGAACAGATATTTATTTGGATTGGCAAAGATGCTAATGAAGTTGAGAAAAAAGAATCTCTGAAGTCTGCCAAAATGTAC
CTTGAGACAGACCCTTCTGGAAGAGACAAGAGGACACCAATTGTCATCATAAAACAGGGCCATGAGCCACCCACATTCACAGGCTGGTTC
CTGGGCTGGGATTCCAGCAAGTGGTAAATTGGTATTTGTAAAAAGCAAACAAACATTACAAGGCAGTTATCTCATTGCTGTTTTGGGAGA
GGAACGGGAAAAGCTTTTTGCTTATTTGTCTTTTGAAAATTAAGGCTGGGCGCGGTGGCTCACACCTGTAATCCCAGCACTTTGAGAGGA
TGAGGTAGGCGGATCACTGGGGTCAGGATTTCGAGACCAGCCTGGCCAACATGGCGAAACCTCGCCTCTACTAAAAATACAAAAAAATTA
GCTGCGCGTGGTGGTGCACGCCTGTAGTCCCTGCTACTTGGAAGGCTGAGACAGGAAAATTGCTTGAACCCAGGAGGCTGAGGTTGCAGT
GAGCCAGGATTGCGCCACCACACTCCAGCCTGGGCAACAGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAATTAACCTCAACCAAACGC
CTATTTTTTAATGCTTAGTTTTGGCTTGAAATTCTTCTTCACCTGGAGTTTTCTTACGTTAATACATTAAAATAACCTGAAGGAAACTTT
CGTTATGGGCCAATATTAGCTCTTATGGAAACTGATTTATATCTTTTTTATGACCTTTCAAAAGTAAAATACTATGCATAATCTAGAAAG
ATTTGTCAGATAGGAAATTTTATAATGCATTAGCCATTAGTCAGAGTTGTTTTTTAACATGCCAGAGAAAAAGTTGTAATGCCTTGGAAG
TTATTCTCTTTTCTATAGATTGTGTTCAAAAGATGTGTATACTTGCAATAAGGTTTATGTTAAGGTGGCTTTAACAATTGGTTGCTATTT
TCCTTCTTTAGTCAATATGACTTTGATGTCATTAACTGCTAAGTGTTATTTTCTAAGAGGAATTTTATCTTTTTTTTAACCTTATTAAAA

>34626_34626_2_GRB10-SCIN_GRB10_chr7_50737419_ENST00000398810_SCIN_chr7_12662426_ENST00000297029_length(amino acids)=654AA_BP=160
MTRPKPVCSQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPR
SIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQVLGEKPELPDGGDDDDIIA
DISNRKMAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMNYSKNTQIQVL
PEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIKQIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYG
GDCYIILYTYPRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQAPAPPTR
LFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSLGGKKDYQT
SPLLETQAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKKESLKSAKMYLETDPSGRDKRTPI

--------------------------------------------------------------
>34626_34626_3_GRB10-SCIN_GRB10_chr7_50737419_ENST00000398812_SCIN_chr7_12662426_ENST00000297029_length(transcript)=2905nt_BP=535nt
AAATGTAATTTGAAGAAGGCAGAAGGAACCCATGGCTTTAGCCGGCTGCCCAGATTCCTTTTTGCACCATCCGTACTACCAGGACAAGGT
GGAGCAGACACCTCGCAGTCAACAAGACCCGGCAGGACCAGGACTCCCCGCACAGTCTGACCGACTTGCGAATCACCAGGAGGATGATGT
GGACCTGGAAGCCCTGGTGAACGATATGAATGCATCCCTGGAGAGCCTGTACTCGGCCTGCAGCATGCAGTCAGACACGGTGCCCCTCCT
GCAGAATGGCCAGCATGCCCGCAGCCAGCCTCGGGCTTCAGGCCCTCCTCGGTCCATCCAGCCACAGGTGTCCCCGAGGCAGAGGGTGCA
GCGCTCCCAGCCTGTGCACATCCTCGCTGTCAGGCGCCTTCAGGAGGAAGACCAGCAGTTTAGAACCTCATCTCTGCCGGCCATCCCCAA
TCCTTTTCCTGAACTCTGTGGCCCTGGGAGCCCCCCTGTGCTCACGCCGGGTTCTTTACCTCCGAGCCAGGCCGCCGCAAAGCAGGTCTT
AGGGGAAAAGCCAGAGCTTCCAGATGGAGGTGATGATGATGACATTATAGCAGACATAAGTAACAGGAAAATGGCTAAACTATACATGGT
TTCAGATGCAAGTGGCTCCATGAGAGTGACTGTGGTGGCAGAAGAAAACCCCTTCTCAATGGCAATGCTGCTGTCTGAAGAATGCTTTAT
TTTGGACCACGGGGCTGCCAAACAAATTTTCGTATGGAAAGGTAAAGATGCTAATCCCCAAGAGAGGAAGGCTGCAATGAAGACAGCTGA
AGAATTTCTACAGCAAATGAATTATTCCAAGAATACCCAAATTCAAGTTCTTCCAGAAGGAGGTGAAACACCAATCTTCAAACAGTTTTT
TAAGGACTGGAGAGATAAAGATCAGAGTGATGGCTTCGGGAAAGTTTATGTCACAGAGAAAGTGGCTCAAATAAAACAAATTCCCTTTGA
TGCCTCAAAATTACACAGTTCTCCGCAGATGGCAGCCCAGCACAATATGGTGGATGATGGTTCTGGCAAAGTGGAGATTTGGCGTGTAGA
AAACAATGGTAGGATCCAAGTTGACCAAAACTCATATGGTGAATTCTATGGTGGTGACTGCTACATCATACTCTACACCTATCCCAGAGG
ACAGATTATCTACACGTGGCAAGGAGCAAATGCCACACGAGATGAGCTGACAACATCTGCGTTCCTGACTGTTCAGTTGGATCGGTCCCT
TGGAGGACAGGCTGTGCAGATCCGAGTCTCCCAAGGCAAAGAGCCTGTTCACCTACTGAGTTTGTTCAAAGACAAACCGCTCATTATTTA
CAAGAATGGAACATCAAAGAAAGGAGGTCAGGCACCTGCTCCCCCTACACGCCTCTTTCAAGTCCGGAGAAACCTGGCATCTATCACCAG
AATTGTGGAGGTTGATGTTGATGCAAATTCACTGAATTCTAACGATGTTTTTGTCCTGAAACTGCCACAAAATAGTGGCTACATCTGGGT
AGGAAAAGGTGCTAGCCAGGAGGAGGAGAAAGGAGCAGAGTATGTAGCAAGTGTCCTAAAGTGCAAAACCTTAAGGATCCAAGAAGGCGA
GGAGCCAGAGGAGTTCTGGAATTCCCTTGGAGGGAAAAAAGACTACCAGACCTCACCACTACTGGAAACCCAGGCTGAAGACCATCCACC
TCGGCTTTACGGCTGCTCTAACAAAACTGGAAGATTTGTTATTGAAGAGATTCCAGGAGAGTTCACCCAGGATGATTTAGCTGAAGATGA
TGTCATGTTACTAGATGCTTGGGAACAGATATTTATTTGGATTGGCAAAGATGCTAATGAAGTTGAGAAAAAAGAATCTCTGAAGTCTGC
CAAAATGTACCTTGAGACAGACCCTTCTGGAAGAGACAAGAGGACACCAATTGTCATCATAAAACAGGGCCATGAGCCACCCACATTCAC
AGGCTGGTTCCTGGGCTGGGATTCCAGCAAGTGGTAAATTGGTATTTGTAAAAAGCAAACAAACATTACAAGGCAGTTATCTCATTGCTG
TTTTGGGAGAGGAACGGGAAAAGCTTTTTGCTTATTTGTCTTTTGAAAATTAAGGCTGGGCGCGGTGGCTCACACCTGTAATCCCAGCAC
TTTGAGAGGATGAGGTAGGCGGATCACTGGGGTCAGGATTTCGAGACCAGCCTGGCCAACATGGCGAAACCTCGCCTCTACTAAAAATAC
AAAAAAATTAGCTGCGCGTGGTGGTGCACGCCTGTAGTCCCTGCTACTTGGAAGGCTGAGACAGGAAAATTGCTTGAACCCAGGAGGCTG
AGGTTGCAGTGAGCCAGGATTGCGCCACCACACTCCAGCCTGGGCAACAGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAATTAACCTC
AACCAAACGCCTATTTTTTAATGCTTAGTTTTGGCTTGAAATTCTTCTTCACCTGGAGTTTTCTTACGTTAATACATTAAAATAACCTGA
AGGAAACTTTCGTTATGGGCCAATATTAGCTCTTATGGAAACTGATTTATATCTTTTTTATGACCTTTCAAAAGTAAAATACTATGCATA
ATCTAGAAAGATTTGTCAGATAGGAAATTTTATAATGCATTAGCCATTAGTCAGAGTTGTTTTTTAACATGCCAGAGAAAAAGTTGTAAT
GCCTTGGAAGTTATTCTCTTTTCTATAGATTGTGTTCAAAAGATGTGTATACTTGCAATAAGGTTTATGTTAAGGTGGCTTTAACAATTG
GTTGCTATTTTCCTTCTTTAGTCAATATGACTTTGATGTCATTAACTGCTAAGTGTTATTTTCTAAGAGGAATTTTATCTTTTTTTTAAC

>34626_34626_3_GRB10-SCIN_GRB10_chr7_50737419_ENST00000398812_SCIN_chr7_12662426_ENST00000297029_length(amino acids)=661AA_BP=167
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQVLGEKPELPDGG
DDDDIIADISNRKMAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMNYSK
NTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIKQIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQN
SYGEFYGGDCYIILYTYPRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQ
APAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSLG
GKKDYQTSPLLETQAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKKESLKSAKMYLETDPSG

--------------------------------------------------------------
>34626_34626_4_GRB10-SCIN_GRB10_chr7_50737419_ENST00000402578_SCIN_chr7_12662426_ENST00000297029_length(transcript)=2965nt_BP=595nt
ACCGACTCTGTGAATTGGGTACCTTCATGATACCCATTTTATAAATGAGAAAACTGAGGTTTTTACTATATGCTGGTCATCATGCTGAGG
ACTTTACTTGGATTTTCTCTCCTGCCAATGCTACGCGGTGGGGACCTTCATGTTCTCCCCTTTGCAGATGAGATTATCAAAGCAGAAAAA
GACCATCTCTCCTACTGAGTAACAGAGGAAACCAGGGCTTGCAGATATTGAGGATGATGTGGACCTGGAAGCCCTGGTGAACGATATGAA
TGCATCCCTGGAGAGCCTGTACTCGGCCTGCAGCATGCAGTCAGACACGGTGCCCCTCCTGCAGAATGGCCAGCATGCCCGCAGCCAGCC
TCGGGCTTCAGGCCCTCCTCGGTCCATCCAGCCACAGGTGTCCCCGAGGCAGAGGGTGCAGCGCTCCCAGCCTGTGCACATCCTCGCTGT
CAGGCGCCTTCAGGAGGAAGACCAGCAGTTTAGAACCTCATCTCTGCCGGCCATCCCCAATCCTTTTCCTGAACTCTGTGGCCCTGGGAG
CCCCCCTGTGCTCACGCCGGGTTCTTTACCTCCGAGCCAGGCCGCCGCAAAGCAGGTCTTAGGGGAAAAGCCAGAGCTTCCAGATGGAGG
TGATGATGATGACATTATAGCAGACATAAGTAACAGGAAAATGGCTAAACTATACATGGTTTCAGATGCAAGTGGCTCCATGAGAGTGAC
TGTGGTGGCAGAAGAAAACCCCTTCTCAATGGCAATGCTGCTGTCTGAAGAATGCTTTATTTTGGACCACGGGGCTGCCAAACAAATTTT
CGTATGGAAAGGTAAAGATGCTAATCCCCAAGAGAGGAAGGCTGCAATGAAGACAGCTGAAGAATTTCTACAGCAAATGAATTATTCCAA
GAATACCCAAATTCAAGTTCTTCCAGAAGGAGGTGAAACACCAATCTTCAAACAGTTTTTTAAGGACTGGAGAGATAAAGATCAGAGTGA
TGGCTTCGGGAAAGTTTATGTCACAGAGAAAGTGGCTCAAATAAAACAAATTCCCTTTGATGCCTCAAAATTACACAGTTCTCCGCAGAT
GGCAGCCCAGCACAATATGGTGGATGATGGTTCTGGCAAAGTGGAGATTTGGCGTGTAGAAAACAATGGTAGGATCCAAGTTGACCAAAA
CTCATATGGTGAATTCTATGGTGGTGACTGCTACATCATACTCTACACCTATCCCAGAGGACAGATTATCTACACGTGGCAAGGAGCAAA
TGCCACACGAGATGAGCTGACAACATCTGCGTTCCTGACTGTTCAGTTGGATCGGTCCCTTGGAGGACAGGCTGTGCAGATCCGAGTCTC
CCAAGGCAAAGAGCCTGTTCACCTACTGAGTTTGTTCAAAGACAAACCGCTCATTATTTACAAGAATGGAACATCAAAGAAAGGAGGTCA
GGCACCTGCTCCCCCTACACGCCTCTTTCAAGTCCGGAGAAACCTGGCATCTATCACCAGAATTGTGGAGGTTGATGTTGATGCAAATTC
ACTGAATTCTAACGATGTTTTTGTCCTGAAACTGCCACAAAATAGTGGCTACATCTGGGTAGGAAAAGGTGCTAGCCAGGAGGAGGAGAA
AGGAGCAGAGTATGTAGCAAGTGTCCTAAAGTGCAAAACCTTAAGGATCCAAGAAGGCGAGGAGCCAGAGGAGTTCTGGAATTCCCTTGG
AGGGAAAAAAGACTACCAGACCTCACCACTACTGGAAACCCAGGCTGAAGACCATCCACCTCGGCTTTACGGCTGCTCTAACAAAACTGG
AAGATTTGTTATTGAAGAGATTCCAGGAGAGTTCACCCAGGATGATTTAGCTGAAGATGATGTCATGTTACTAGATGCTTGGGAACAGAT
ATTTATTTGGATTGGCAAAGATGCTAATGAAGTTGAGAAAAAAGAATCTCTGAAGTCTGCCAAAATGTACCTTGAGACAGACCCTTCTGG
AAGAGACAAGAGGACACCAATTGTCATCATAAAACAGGGCCATGAGCCACCCACATTCACAGGCTGGTTCCTGGGCTGGGATTCCAGCAA
GTGGTAAATTGGTATTTGTAAAAAGCAAACAAACATTACAAGGCAGTTATCTCATTGCTGTTTTGGGAGAGGAACGGGAAAAGCTTTTTG
CTTATTTGTCTTTTGAAAATTAAGGCTGGGCGCGGTGGCTCACACCTGTAATCCCAGCACTTTGAGAGGATGAGGTAGGCGGATCACTGG
GGTCAGGATTTCGAGACCAGCCTGGCCAACATGGCGAAACCTCGCCTCTACTAAAAATACAAAAAAATTAGCTGCGCGTGGTGGTGCACG
CCTGTAGTCCCTGCTACTTGGAAGGCTGAGACAGGAAAATTGCTTGAACCCAGGAGGCTGAGGTTGCAGTGAGCCAGGATTGCGCCACCA
CACTCCAGCCTGGGCAACAGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAATTAACCTCAACCAAACGCCTATTTTTTAATGCTTAGTT
TTGGCTTGAAATTCTTCTTCACCTGGAGTTTTCTTACGTTAATACATTAAAATAACCTGAAGGAAACTTTCGTTATGGGCCAATATTAGC
TCTTATGGAAACTGATTTATATCTTTTTTATGACCTTTCAAAAGTAAAATACTATGCATAATCTAGAAAGATTTGTCAGATAGGAAATTT
TATAATGCATTAGCCATTAGTCAGAGTTGTTTTTTAACATGCCAGAGAAAAAGTTGTAATGCCTTGGAAGTTATTCTCTTTTCTATAGAT
TGTGTTCAAAAGATGTGTATACTTGCAATAAGGTTTATGTTAAGGTGGCTTTAACAATTGGTTGCTATTTTCCTTCTTTAGTCAATATGA

>34626_34626_4_GRB10-SCIN_GRB10_chr7_50737419_ENST00000402578_SCIN_chr7_12662426_ENST00000297029_length(amino acids)=610AA_BP=116
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQVLGEKPELPDGGDDDDIIADISNRKMAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFIL
DHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIKQIPFDA
SKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYIILYTYPRGQIIYTWQGANATRDELTTSAFLTVQLDRSLG
GQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIWVG
KGASQEEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSLGGKKDYQTSPLLETQAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDV

--------------------------------------------------------------
>34626_34626_5_GRB10-SCIN_GRB10_chr7_50737419_ENST00000439599_SCIN_chr7_12662426_ENST00000297029_length(transcript)=2856nt_BP=486nt
ATGCAAGCTGCCGGCCCTCTGTTCCGTAGTAAGGACAAGGTGGAGCAGACACCTCGCAGTCAACAAGACCCGGCAGGACCAGGACTCCCC
GCACAGTCTGACCGACTTGCGAATCACCAGGAGGATGATGTGGACCTGGAAGCCCTGGTGAACGATATGAATGCATCCCTGGAGAGCCTG
TACTCGGCCTGCAGCATGCAGTCAGACACGGTGCCCCTCCTGCAGAATGGCCAGCATGCCCGCAGCCAGCCTCGGGCTTCAGGCCCTCCT
CGGTCCATCCAGCCACAGGTGTCCCCGAGGCAGAGGGTGCAGCGCTCCCAGCCTGTGCACATCCTCGCTGTCAGGCGCCTTCAGGAGGAA
GACCAGCAGTTTAGAACCTCATCTCTGCCGGCCATCCCCAATCCTTTTCCTGAACTCTGTGGCCCTGGGAGCCCCCCTGTGCTCACGCCG
GGTTCTTTACCTCCGAGCCAGGCCGCCGCAAAGCAGGTCTTAGGGGAAAAGCCAGAGCTTCCAGATGGAGGTGATGATGATGACATTATA
GCAGACATAAGTAACAGGAAAATGGCTAAACTATACATGGTTTCAGATGCAAGTGGCTCCATGAGAGTGACTGTGGTGGCAGAAGAAAAC
CCCTTCTCAATGGCAATGCTGCTGTCTGAAGAATGCTTTATTTTGGACCACGGGGCTGCCAAACAAATTTTCGTATGGAAAGGTAAAGAT
GCTAATCCCCAAGAGAGGAAGGCTGCAATGAAGACAGCTGAAGAATTTCTACAGCAAATGAATTATTCCAAGAATACCCAAATTCAAGTT
CTTCCAGAAGGAGGTGAAACACCAATCTTCAAACAGTTTTTTAAGGACTGGAGAGATAAAGATCAGAGTGATGGCTTCGGGAAAGTTTAT
GTCACAGAGAAAGTGGCTCAAATAAAACAAATTCCCTTTGATGCCTCAAAATTACACAGTTCTCCGCAGATGGCAGCCCAGCACAATATG
GTGGATGATGGTTCTGGCAAAGTGGAGATTTGGCGTGTAGAAAACAATGGTAGGATCCAAGTTGACCAAAACTCATATGGTGAATTCTAT
GGTGGTGACTGCTACATCATACTCTACACCTATCCCAGAGGACAGATTATCTACACGTGGCAAGGAGCAAATGCCACACGAGATGAGCTG
ACAACATCTGCGTTCCTGACTGTTCAGTTGGATCGGTCCCTTGGAGGACAGGCTGTGCAGATCCGAGTCTCCCAAGGCAAAGAGCCTGTT
CACCTACTGAGTTTGTTCAAAGACAAACCGCTCATTATTTACAAGAATGGAACATCAAAGAAAGGAGGTCAGGCACCTGCTCCCCCTACA
CGCCTCTTTCAAGTCCGGAGAAACCTGGCATCTATCACCAGAATTGTGGAGGTTGATGTTGATGCAAATTCACTGAATTCTAACGATGTT
TTTGTCCTGAAACTGCCACAAAATAGTGGCTACATCTGGGTAGGAAAAGGTGCTAGCCAGGAGGAGGAGAAAGGAGCAGAGTATGTAGCA
AGTGTCCTAAAGTGCAAAACCTTAAGGATCCAAGAAGGCGAGGAGCCAGAGGAGTTCTGGAATTCCCTTGGAGGGAAAAAAGACTACCAG
ACCTCACCACTACTGGAAACCCAGGCTGAAGACCATCCACCTCGGCTTTACGGCTGCTCTAACAAAACTGGAAGATTTGTTATTGAAGAG
ATTCCAGGAGAGTTCACCCAGGATGATTTAGCTGAAGATGATGTCATGTTACTAGATGCTTGGGAACAGATATTTATTTGGATTGGCAAA
GATGCTAATGAAGTTGAGAAAAAAGAATCTCTGAAGTCTGCCAAAATGTACCTTGAGACAGACCCTTCTGGAAGAGACAAGAGGACACCA
ATTGTCATCATAAAACAGGGCCATGAGCCACCCACATTCACAGGCTGGTTCCTGGGCTGGGATTCCAGCAAGTGGTAAATTGGTATTTGT
AAAAAGCAAACAAACATTACAAGGCAGTTATCTCATTGCTGTTTTGGGAGAGGAACGGGAAAAGCTTTTTGCTTATTTGTCTTTTGAAAA
TTAAGGCTGGGCGCGGTGGCTCACACCTGTAATCCCAGCACTTTGAGAGGATGAGGTAGGCGGATCACTGGGGTCAGGATTTCGAGACCA
GCCTGGCCAACATGGCGAAACCTCGCCTCTACTAAAAATACAAAAAAATTAGCTGCGCGTGGTGGTGCACGCCTGTAGTCCCTGCTACTT
GGAAGGCTGAGACAGGAAAATTGCTTGAACCCAGGAGGCTGAGGTTGCAGTGAGCCAGGATTGCGCCACCACACTCCAGCCTGGGCAACA
GAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAATTAACCTCAACCAAACGCCTATTTTTTAATGCTTAGTTTTGGCTTGAAATTCTTCTT
CACCTGGAGTTTTCTTACGTTAATACATTAAAATAACCTGAAGGAAACTTTCGTTATGGGCCAATATTAGCTCTTATGGAAACTGATTTA
TATCTTTTTTATGACCTTTCAAAAGTAAAATACTATGCATAATCTAGAAAGATTTGTCAGATAGGAAATTTTATAATGCATTAGCCATTA
GTCAGAGTTGTTTTTTAACATGCCAGAGAAAAAGTTGTAATGCCTTGGAAGTTATTCTCTTTTCTATAGATTGTGTTCAAAAGATGTGTA
TACTTGCAATAAGGTTTATGTTAAGGTGGCTTTAACAATTGGTTGCTATTTTCCTTCTTTAGTCAATATGACTTTGATGTCATTAACTGC

>34626_34626_5_GRB10-SCIN_GRB10_chr7_50737419_ENST00000439599_SCIN_chr7_12662426_ENST00000297029_length(amino acids)=655AA_BP=161
MQAAGPLFRSKDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPP
RSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQVLGEKPELPDGGDDDDII
ADISNRKMAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMNYSKNTQIQV
LPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIKQIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFY
GGDCYIILYTYPRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQAPAPPT
RLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSLGGKKDYQ
TSPLLETQAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKKESLKSAKMYLETDPSGRDKRTP

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for GRB10-SCIN

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GRB10-SCIN

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for GRB10-SCIN

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source