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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GRB2-CASKIN2 (FusionGDB2 ID:34639)

Fusion Gene Summary for GRB2-CASKIN2

Fusion gene summary

Fusion gene information	Fusion gene name: GRB2-CASKIN2
	Fusion gene ID: 34639
		Hgene	Tgene
	Gene symbol	GRB2	CASKIN2
	Gene ID	2885	57513
	Gene name	growth factor receptor bound protein 2	CASK interacting protein 2
	Synonyms	ASH\|EGFRBP-GRB2\|Grb3-3\|MST084\|MSTP084\|NCKAP2	ANKS5B
	Cytomap	17q25.1	17q25.1
	Type of gene	protein-coding	protein-coding
	Description	growth factor receptor-bound protein 2HT027SH2/SH3 adapter GRB2abundant SRC homologyepidermal growth factor receptor-binding protein GRB2epididymis secretory sperm binding proteingrowth factor receptor-bound protein 3protein Ash	caskin-2
	Modification date	20200327	20200313
	UniProtAcc	P62993	Q8WXE0
	Ensembl transtripts involved in fusion gene	ENST00000316615, ENST00000316804, ENST00000392562, ENST00000392563, ENST00000392564, ENST00000578961, ENST00000462266,	ENST00000433559, ENST00000581870, ENST00000321617,
Fusion gene scores	* DoF score	18 X 13 X 11=2574	2 X 3 X 3=18
	# samples	25	4
	** MAII score	log2(25/2574*10)=-3.36401205355861 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: GRB2 [Title/Abstract] AND CASKIN2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GRB2(73389632)-CASKIN2(73504366), # samples:1 GRB2(73367940)-CASKIN2(73499220), # samples:1 GRB2(73389632)-CASKIN2(73502010), # samples:1
Anticipated loss of major functional domain due to fusion event.	GRB2-CASKIN2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across GRB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CASKIN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-98-A53A	GRB2	chr17	73389632	-	CASKIN2	chr17	73504366	-
ChimerDB4	OV	TCGA-04-1517-01A	GRB2	chr17	73367940	-	CASKIN2	chr17	73499220	-
ChimerDB4	TGCT	TCGA-W4-A7U3	GRB2	chr17	73389632	-	CASKIN2	chr17	73502010	-

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Fusion Gene ORF analysis for GRB2-CASKIN2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000316615	ENST00000433559	GRB2	chr17	73389632	-	CASKIN2	chr17	73504366	-
5CDS-5UTR	ENST00000316615	ENST00000581870	GRB2	chr17	73389632	-	CASKIN2	chr17	73504366	-
5CDS-5UTR	ENST00000316804	ENST00000433559	GRB2	chr17	73389632	-	CASKIN2	chr17	73504366	-
5CDS-5UTR	ENST00000316804	ENST00000581870	GRB2	chr17	73389632	-	CASKIN2	chr17	73504366	-
5CDS-5UTR	ENST00000392562	ENST00000433559	GRB2	chr17	73389632	-	CASKIN2	chr17	73504366	-
5CDS-5UTR	ENST00000392562	ENST00000581870	GRB2	chr17	73389632	-	CASKIN2	chr17	73504366	-
5CDS-5UTR	ENST00000392563	ENST00000433559	GRB2	chr17	73389632	-	CASKIN2	chr17	73504366	-
5CDS-5UTR	ENST00000392563	ENST00000581870	GRB2	chr17	73389632	-	CASKIN2	chr17	73504366	-
5CDS-5UTR	ENST00000392564	ENST00000433559	GRB2	chr17	73389632	-	CASKIN2	chr17	73504366	-
5CDS-5UTR	ENST00000392564	ENST00000581870	GRB2	chr17	73389632	-	CASKIN2	chr17	73504366	-
5CDS-5UTR	ENST00000578961	ENST00000433559	GRB2	chr17	73389632	-	CASKIN2	chr17	73504366	-
5CDS-5UTR	ENST00000578961	ENST00000581870	GRB2	chr17	73389632	-	CASKIN2	chr17	73504366	-
Frame-shift	ENST00000316615	ENST00000321617	GRB2	chr17	73389632	-	CASKIN2	chr17	73502010	-
Frame-shift	ENST00000316615	ENST00000433559	GRB2	chr17	73389632	-	CASKIN2	chr17	73502010	-
Frame-shift	ENST00000316615	ENST00000581870	GRB2	chr17	73389632	-	CASKIN2	chr17	73502010	-
Frame-shift	ENST00000316804	ENST00000321617	GRB2	chr17	73389632	-	CASKIN2	chr17	73502010	-
Frame-shift	ENST00000316804	ENST00000433559	GRB2	chr17	73389632	-	CASKIN2	chr17	73502010	-
Frame-shift	ENST00000316804	ENST00000581870	GRB2	chr17	73389632	-	CASKIN2	chr17	73502010	-
Frame-shift	ENST00000392562	ENST00000321617	GRB2	chr17	73389632	-	CASKIN2	chr17	73502010	-
Frame-shift	ENST00000392562	ENST00000433559	GRB2	chr17	73389632	-	CASKIN2	chr17	73502010	-
Frame-shift	ENST00000392562	ENST00000581870	GRB2	chr17	73389632	-	CASKIN2	chr17	73502010	-
Frame-shift	ENST00000392563	ENST00000321617	GRB2	chr17	73389632	-	CASKIN2	chr17	73504366	-
Frame-shift	ENST00000392564	ENST00000321617	GRB2	chr17	73389632	-	CASKIN2	chr17	73504366	-
Frame-shift	ENST00000578961	ENST00000321617	GRB2	chr17	73389632	-	CASKIN2	chr17	73504366	-
In-frame	ENST00000316615	ENST00000321617	GRB2	chr17	73389632	-	CASKIN2	chr17	73504366	-
In-frame	ENST00000316804	ENST00000321617	GRB2	chr17	73389632	-	CASKIN2	chr17	73504366	-
In-frame	ENST00000392562	ENST00000321617	GRB2	chr17	73389632	-	CASKIN2	chr17	73504366	-
In-frame	ENST00000392563	ENST00000321617	GRB2	chr17	73389632	-	CASKIN2	chr17	73502010	-
In-frame	ENST00000392563	ENST00000433559	GRB2	chr17	73389632	-	CASKIN2	chr17	73502010	-
In-frame	ENST00000392563	ENST00000581870	GRB2	chr17	73389632	-	CASKIN2	chr17	73502010	-
In-frame	ENST00000392564	ENST00000321617	GRB2	chr17	73389632	-	CASKIN2	chr17	73502010	-
In-frame	ENST00000392564	ENST00000433559	GRB2	chr17	73389632	-	CASKIN2	chr17	73502010	-
In-frame	ENST00000392564	ENST00000581870	GRB2	chr17	73389632	-	CASKIN2	chr17	73502010	-
In-frame	ENST00000578961	ENST00000321617	GRB2	chr17	73389632	-	CASKIN2	chr17	73502010	-
In-frame	ENST00000578961	ENST00000433559	GRB2	chr17	73389632	-	CASKIN2	chr17	73502010	-
In-frame	ENST00000578961	ENST00000581870	GRB2	chr17	73389632	-	CASKIN2	chr17	73502010	-
intron-3CDS	ENST00000316615	ENST00000321617	GRB2	chr17	73367940	-	CASKIN2	chr17	73499220	-
intron-3CDS	ENST00000316615	ENST00000433559	GRB2	chr17	73367940	-	CASKIN2	chr17	73499220	-
intron-3CDS	ENST00000316804	ENST00000321617	GRB2	chr17	73367940	-	CASKIN2	chr17	73499220	-
intron-3CDS	ENST00000316804	ENST00000433559	GRB2	chr17	73367940	-	CASKIN2	chr17	73499220	-
intron-3CDS	ENST00000392562	ENST00000321617	GRB2	chr17	73367940	-	CASKIN2	chr17	73499220	-
intron-3CDS	ENST00000392562	ENST00000433559	GRB2	chr17	73367940	-	CASKIN2	chr17	73499220	-
intron-3CDS	ENST00000392563	ENST00000321617	GRB2	chr17	73367940	-	CASKIN2	chr17	73499220	-
intron-3CDS	ENST00000392563	ENST00000433559	GRB2	chr17	73367940	-	CASKIN2	chr17	73499220	-
intron-3CDS	ENST00000392564	ENST00000321617	GRB2	chr17	73367940	-	CASKIN2	chr17	73499220	-
intron-3CDS	ENST00000392564	ENST00000433559	GRB2	chr17	73367940	-	CASKIN2	chr17	73499220	-
intron-3CDS	ENST00000462266	ENST00000321617	GRB2	chr17	73389632	-	CASKIN2	chr17	73504366	-
intron-3CDS	ENST00000462266	ENST00000321617	GRB2	chr17	73367940	-	CASKIN2	chr17	73499220	-
intron-3CDS	ENST00000462266	ENST00000321617	GRB2	chr17	73389632	-	CASKIN2	chr17	73502010	-
intron-3CDS	ENST00000462266	ENST00000433559	GRB2	chr17	73367940	-	CASKIN2	chr17	73499220	-
intron-3CDS	ENST00000462266	ENST00000433559	GRB2	chr17	73389632	-	CASKIN2	chr17	73502010	-
intron-3CDS	ENST00000462266	ENST00000581870	GRB2	chr17	73389632	-	CASKIN2	chr17	73502010	-
intron-3CDS	ENST00000578961	ENST00000321617	GRB2	chr17	73367940	-	CASKIN2	chr17	73499220	-
intron-3CDS	ENST00000578961	ENST00000433559	GRB2	chr17	73367940	-	CASKIN2	chr17	73499220	-
intron-5UTR	ENST00000462266	ENST00000433559	GRB2	chr17	73389632	-	CASKIN2	chr17	73504366	-
intron-5UTR	ENST00000462266	ENST00000581870	GRB2	chr17	73389632	-	CASKIN2	chr17	73504366	-
intron-intron	ENST00000316615	ENST00000581870	GRB2	chr17	73367940	-	CASKIN2	chr17	73499220	-
intron-intron	ENST00000316804	ENST00000581870	GRB2	chr17	73367940	-	CASKIN2	chr17	73499220	-
intron-intron	ENST00000392562	ENST00000581870	GRB2	chr17	73367940	-	CASKIN2	chr17	73499220	-
intron-intron	ENST00000392563	ENST00000581870	GRB2	chr17	73367940	-	CASKIN2	chr17	73499220	-
intron-intron	ENST00000392564	ENST00000581870	GRB2	chr17	73367940	-	CASKIN2	chr17	73499220	-
intron-intron	ENST00000462266	ENST00000581870	GRB2	chr17	73367940	-	CASKIN2	chr17	73499220	-
intron-intron	ENST00000578961	ENST00000581870	GRB2	chr17	73367940	-	CASKIN2	chr17	73499220	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000392562	GRB2	chr17	73389632	-	ENST00000321617	CASKIN2	chr17	73504366	-	5195	861	866	4375	1169
ENST00000316804	GRB2	chr17	73389632	-	ENST00000321617	CASKIN2	chr17	73504366	-	4714	380	385	3894	1169
ENST00000316615	GRB2	chr17	73389632	-	ENST00000321617	CASKIN2	chr17	73504366	-	4770	436	441	3950	1169
ENST00000392563	GRB2	chr17	73389632	-	ENST00000321617	CASKIN2	chr17	73502010	-	3808	106	28	2988	986
ENST00000392563	GRB2	chr17	73389632	-	ENST00000433559	CASKIN2	chr17	73502010	-	3260	106	28	2988	986
ENST00000392563	GRB2	chr17	73389632	-	ENST00000581870	CASKIN2	chr17	73502010	-	548	106	28	351	107
ENST00000392564	GRB2	chr17	73389632	-	ENST00000321617	CASKIN2	chr17	73502010	-	4016	314	236	3196	986
ENST00000392564	GRB2	chr17	73389632	-	ENST00000433559	CASKIN2	chr17	73502010	-	3468	314	236	3196	986
ENST00000392564	GRB2	chr17	73389632	-	ENST00000581870	CASKIN2	chr17	73502010	-	756	314	236	559	107
ENST00000578961	GRB2	chr17	73389632	-	ENST00000321617	CASKIN2	chr17	73502010	-	3955	253	175	3135	986
ENST00000578961	GRB2	chr17	73389632	-	ENST00000433559	CASKIN2	chr17	73502010	-	3407	253	175	3135	986
ENST00000578961	GRB2	chr17	73389632	-	ENST00000581870	CASKIN2	chr17	73502010	-	695	253	175	498	107

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000392562	ENST00000321617	GRB2	chr17	73389632	-	CASKIN2	chr17	73504366	-	0.021474853	0.9785251
ENST00000316804	ENST00000321617	GRB2	chr17	73389632	-	CASKIN2	chr17	73504366	-	0.019444358	0.9805556
ENST00000316615	ENST00000321617	GRB2	chr17	73389632	-	CASKIN2	chr17	73504366	-	0.020313459	0.9796865
ENST00000392563	ENST00000321617	GRB2	chr17	73389632	-	CASKIN2	chr17	73502010	-	0.008410401	0.9915896
ENST00000392563	ENST00000433559	GRB2	chr17	73389632	-	CASKIN2	chr17	73502010	-	0.014179851	0.9858202
ENST00000392563	ENST00000581870	GRB2	chr17	73389632	-	CASKIN2	chr17	73502010	-	0.0150904	0.9849096
ENST00000392564	ENST00000321617	GRB2	chr17	73389632	-	CASKIN2	chr17	73502010	-	0.008688758	0.9913113
ENST00000392564	ENST00000433559	GRB2	chr17	73389632	-	CASKIN2	chr17	73502010	-	0.014024896	0.9859751
ENST00000392564	ENST00000581870	GRB2	chr17	73389632	-	CASKIN2	chr17	73502010	-	0.027104437	0.97289556
ENST00000578961	ENST00000321617	GRB2	chr17	73389632	-	CASKIN2	chr17	73502010	-	0.008107565	0.99189246
ENST00000578961	ENST00000433559	GRB2	chr17	73389632	-	CASKIN2	chr17	73502010	-	0.01310082	0.98689926
ENST00000578961	ENST00000581870	GRB2	chr17	73389632	-	CASKIN2	chr17	73502010	-	0.028235713	0.9717642

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Fusion Genomic Features for GRB2-CASKIN2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GRB2-CASKIN2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:73389632/chr17:73504366)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GRB2 P62993	CASKIN2 Q8WXE0
FUNCTION: Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. {ECO:0000269\|PubMed:1322798, ECO:0000269\|PubMed:19815557}.; FUNCTION: [Isoform 2]: Does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death. {ECO:0000269\|PubMed:8178156}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CASKIN2

chr17:73389632

chr17:73502010

ENST00000321617

685_1133

242

1203.0

Compositional bias

Note=Pro-rich

Tgene

CASKIN2

chr17:73389632

chr17:73502010

ENST00000433559

685_1133

160

1121.0

Compositional bias

Note=Pro-rich

Tgene

CASKIN2

chr17:73389632

chr17:73504366

ENST00000321617

685_1133

1203.0

Compositional bias

Note=Pro-rich

Tgene

CASKIN2

chr17:73389632

chr17:73504366

ENST00000433559

685_1133

1121.0

Compositional bias

Note=Pro-rich

Tgene

CASKIN2

chr17:73389632

chr17:73502010

ENST00000321617

281_347

242

1203.0

Domain

SH3

Tgene

CASKIN2

chr17:73389632

chr17:73502010

ENST00000321617

489_552

242

1203.0

Domain

SAM 1

Tgene

CASKIN2

chr17:73389632

chr17:73502010

ENST00000321617

558_622

242

1203.0

Domain

SAM 2

Tgene

CASKIN2

chr17:73389632

chr17:73502010

ENST00000433559

281_347

160

1121.0

Domain

SH3

Tgene

CASKIN2

chr17:73389632

chr17:73502010

ENST00000433559

489_552

160

1121.0

Domain

SAM 1

Tgene

CASKIN2

chr17:73389632

chr17:73502010

ENST00000433559

558_622

160

1121.0

Domain

SAM 2

Tgene

CASKIN2

chr17:73389632

chr17:73504366

ENST00000321617

281_347

1203.0

Domain

SH3

Tgene

CASKIN2

chr17:73389632

chr17:73504366

ENST00000321617

489_552

1203.0

Domain

SAM 1

Tgene

CASKIN2

chr17:73389632

chr17:73504366

ENST00000321617

558_622

1203.0

Domain

SAM 2

Tgene

CASKIN2

chr17:73389632

chr17:73504366

ENST00000433559

281_347

1121.0

Domain

SH3

Tgene

CASKIN2

chr17:73389632

chr17:73504366

ENST00000433559

489_552

1121.0

Domain

SAM 1

Tgene

CASKIN2

chr17:73389632

chr17:73504366

ENST00000433559

558_622

1121.0

Domain

SAM 2

Tgene

CASKIN2

chr17:73389632

chr17:73502010

ENST00000433559

188_217

160

1121.0

Repeat

Note=ANK 5

Tgene

CASKIN2

chr17:73389632

chr17:73502010

ENST00000433559

220_249

160

1121.0

Repeat

Note=ANK 6

Tgene

CASKIN2

chr17:73389632

chr17:73504366

ENST00000321617

114_143

1203.0

Repeat

Note=ANK 3

Tgene

CASKIN2

chr17:73389632

chr17:73504366

ENST00000321617

147_176

1203.0

Repeat

Note=ANK 4

Tgene

CASKIN2

chr17:73389632

chr17:73504366

ENST00000321617

188_217

1203.0

Repeat

Note=ANK 5

Tgene

CASKIN2

chr17:73389632

chr17:73504366

ENST00000321617

220_249

1203.0

Repeat

Note=ANK 6

Tgene

CASKIN2

chr17:73389632

chr17:73504366

ENST00000321617

48_77

1203.0

Repeat

Note=ANK 1

Tgene

CASKIN2

chr17:73389632

chr17:73504366

ENST00000321617

81_110

1203.0

Repeat

Note=ANK 2

Tgene

CASKIN2

chr17:73389632

chr17:73504366

ENST00000433559

114_143

1121.0

Repeat

Note=ANK 3

Tgene

CASKIN2

chr17:73389632

chr17:73504366

ENST00000433559

147_176

1121.0

Repeat

Note=ANK 4

Tgene

CASKIN2

chr17:73389632

chr17:73504366

ENST00000433559

188_217

1121.0

Repeat

Note=ANK 5

Tgene

CASKIN2

chr17:73389632

chr17:73504366

ENST00000433559

220_249

1121.0

Repeat

Note=ANK 6

Tgene

CASKIN2

chr17:73389632

chr17:73504366

ENST00000433559

48_77

1121.0

Repeat

Note=ANK 1

Tgene

CASKIN2

chr17:73389632

chr17:73504366

ENST00000433559

81_110

1121.0

Repeat

Note=ANK 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GRB2

chr17:73389632

chr17:73502010

ENST00000316615

156_215

177.0

Domain

SH3 2

Hgene

GRB2

chr17:73389632

chr17:73502010

ENST00000316615

1_58

177.0

Domain

SH3 1

Hgene

GRB2

chr17:73389632

chr17:73502010

ENST00000316615

60_152

177.0

Domain

SH2

Hgene

GRB2

chr17:73389632

chr17:73502010

ENST00000316804

156_215

218.0

Domain

SH3 2

Hgene

GRB2

chr17:73389632

chr17:73502010

ENST00000316804

1_58

218.0

Domain

SH3 1

Hgene

GRB2

chr17:73389632

chr17:73502010

ENST00000316804

60_152

218.0

Domain

SH2

Hgene

GRB2

chr17:73389632

chr17:73502010

ENST00000392562

156_215

218.0

Domain

SH3 2

Hgene

GRB2

chr17:73389632

chr17:73502010

ENST00000392562

1_58

218.0

Domain

SH3 1

Hgene

GRB2

chr17:73389632

chr17:73502010

ENST00000392562

60_152

218.0

Domain

SH2

Hgene

GRB2

chr17:73389632

chr17:73502010

ENST00000392563

156_215

177.0

Domain

SH3 2

Hgene

GRB2

chr17:73389632

chr17:73502010

ENST00000392563

1_58

177.0

Domain

SH3 1

Hgene

GRB2

chr17:73389632

chr17:73502010

ENST00000392563

60_152

177.0

Domain

SH2

Hgene

GRB2

chr17:73389632

chr17:73502010

ENST00000392564

156_215

218.0

Domain

SH3 2

Hgene

GRB2

chr17:73389632

chr17:73502010

ENST00000392564

1_58

218.0

Domain

SH3 1

Hgene

GRB2

chr17:73389632

chr17:73502010

ENST00000392564

60_152

218.0

Domain

SH2

Hgene

GRB2

chr17:73389632

chr17:73504366

ENST00000316615

156_215

177.0

Domain

SH3 2

Hgene

GRB2

chr17:73389632

chr17:73504366

ENST00000316615

1_58

177.0

Domain

SH3 1

Hgene

GRB2

chr17:73389632

chr17:73504366

ENST00000316615

60_152

177.0

Domain

SH2

Hgene

GRB2

chr17:73389632

chr17:73504366

ENST00000316804

156_215

218.0

Domain

SH3 2

Hgene

GRB2

chr17:73389632

chr17:73504366

ENST00000316804

1_58

218.0

Domain

SH3 1

Hgene

GRB2

chr17:73389632

chr17:73504366

ENST00000316804

60_152

218.0

Domain

SH2

Hgene

GRB2

chr17:73389632

chr17:73504366

ENST00000392562

156_215

218.0

Domain

SH3 2

Hgene

GRB2

chr17:73389632

chr17:73504366

ENST00000392562

1_58

218.0

Domain

SH3 1

Hgene

GRB2

chr17:73389632

chr17:73504366

ENST00000392562

60_152

218.0

Domain

SH2

Hgene

GRB2

chr17:73389632

chr17:73504366

ENST00000392563

156_215

177.0

Domain

SH3 2

Hgene

GRB2

chr17:73389632

chr17:73504366

ENST00000392563

1_58

177.0

Domain

SH3 1

Hgene

GRB2

chr17:73389632

chr17:73504366

ENST00000392563

60_152

177.0

Domain

SH2

Hgene

GRB2

chr17:73389632

chr17:73504366

ENST00000392564

156_215

218.0

Domain

SH3 2

Hgene

GRB2

chr17:73389632

chr17:73504366

ENST00000392564

1_58

218.0

Domain

SH3 1

Hgene

GRB2

chr17:73389632

chr17:73504366

ENST00000392564

60_152

218.0

Domain

SH2

Tgene

CASKIN2

chr17:73389632

chr17:73502010

ENST00000321617

114_143

242

1203.0

Repeat

Note=ANK 3

Tgene

CASKIN2

chr17:73389632

chr17:73502010

ENST00000321617

147_176

242

1203.0

Repeat

Note=ANK 4

Tgene

CASKIN2

chr17:73389632

chr17:73502010

ENST00000321617

188_217

242

1203.0

Repeat

Note=ANK 5

Tgene

CASKIN2

chr17:73389632

chr17:73502010

ENST00000321617

220_249

242

1203.0

Repeat

Note=ANK 6

Tgene

CASKIN2

chr17:73389632

chr17:73502010

ENST00000321617

48_77

242

1203.0

Repeat

Note=ANK 1

Tgene

CASKIN2

chr17:73389632

chr17:73502010

ENST00000321617

81_110

242

1203.0

Repeat

Note=ANK 2

Tgene

CASKIN2

chr17:73389632

chr17:73502010

ENST00000433559

114_143

160

1121.0

Repeat

Note=ANK 3

Tgene

CASKIN2

chr17:73389632

chr17:73502010

ENST00000433559

147_176

160

1121.0

Repeat

Note=ANK 4

Tgene

CASKIN2

chr17:73389632

chr17:73502010

ENST00000433559

48_77

160

1121.0

Repeat

Note=ANK 1

Tgene

CASKIN2

chr17:73389632

chr17:73502010

ENST00000433559

81_110

160

1121.0

Repeat

Note=ANK 2

Top

Fusion Gene Sequence for GRB2-CASKIN2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>34639_34639_1_GRB2-CASKIN2_GRB2_chr17_73389632_ENST00000316615_CASKIN2_chr17_73504366_ENST00000321617_length(transcript)=4770nt_BP=436nt
AAGTTCTCGCGGGACACCGACGGGGAGCGGAAGCCAGGAGGTATTGCTGCTTCGGCGACCGGGCGGCGGCAGCGGCGGCGGCGGCTGTGG
CAGAGTCTGTGCCTGTGGCGGTGACGGCGGCGGGAGCAAGCGCTGCCCTCGCAGAGCAGCCTTGGGGTCGCCGGCCGCTCGCAGCGTTGT
GGAGGGGCGGGCCGGACGCTGAGCGGAGCAGCTGCGCCACGGGTGGCATTGTGTGTCCCAGAGTGCCGGAGCGAGTCCCAGAAGAGAGGC
GAGGCTAAGCCCAGAGCGCTGGGTTGCTTCAGCAGGGAAGACTCCCTTCCCCCTGCTTCAGGCTGCTGAGCACTGAGCAGCGCTCAGAAT
GGAAGCCATCGCCAAATATGACTTCAAAGCTACTGCAGACGACGAGCTGAGCTTCAAAAGGGGGGACATCCTCAAGAGCTCCTGGGCTCC
ACAAAGAGGCTCAACGTGAACTACCAGGATGCTGATGGATTCTCTGCCCTCCACCACGCTGCTTTGGGGGGCAGCCTGGAGCTCATAGCC
TTGCTGCTAGAGGCTCAGGCCACTGTTGACATCAAGGACAGCAATGGCATGCGCCCGCTGCACTACGCAGCCTGGCAGGGCCGGCTGGAG
CCTGTGAGGCTGCTGCTGCGCGCCTCTGCGGCTGTCAATGCCGCCTCGCTGGACGGACAGATCCCCCTGCACCTGGCTGCACAGTATGGA
CATTATGAGGTGTCAGAAATGCTCCTCCAGCATCAGTCCAACCCATGCCTGGTCAACAAGGCCAAGAAGACGCCCCTGGACCTGGCCTGT
GAATTTGGCCGACTCAAGGTGGCCCAGCTGCTTCTGAACAGCCACTTATGTGTGGCACTGCTGGAGGGTGAGGCCAAAGACCCGTGTGAC
CCCAACTACACCACGCCCCTGCACTTGGCTGCCAAGAATGGCCACAGAGAAGTCATCAGGCAGCTCCTGAGAGCTGGGATCGAGATCAAC
CGCCAGACCAAGACGGGTACGGCGCTCCACGAGGCCGCACTGTATGGCAAGACCGAGGTGGTGCGGCTGCTTCTGGAGGGAGGTGTGGAC
GTGAACATCCGGAATACGTATAACCAGACGGCGCTGGACATAGTGAATCAGTTCACCACCTCCCAGGCCAGCCGGGAAATCAAGCAGCTA
CTGCGGGAGGCCTCAGGGATCCTGAAGGTCCGAGCGCTCAAGGATTTCTGGAACCTCCACGATCCCACTGCTCTCAATGTCCGGGCAGGG
GATGTCATCACGGTGCTAGAACAGCATCCCGACGGCCGCTGGAAGGGCCACATCCACGAGAGCCAGAGGGGCACAGACCGCATAGGCTAC
TTCCCCCCGGGCATTGTCGAGGTGGTCAGCAAGCGGGTGGGCATCCCTGCAGCCCGCCTCCCCTCCGCACCCACCCCCCTGCGCCCAGGC
TTCTCCCGGACACCGCAGCCTCCTGCCGAAGAACCCCCGCACCCTCTTACCTACAGCCAGCTTCCTCGGGTGGGCCTCAGCCCAGACAGC
CCAGCAGGTGACAGGAATAGTGTGGGCAGTGAGGGCAGCGTGGGCAGCATCCGCAGTGCCGGCAGCGGGCAGAGCTCTGAGGGCACTAAT
GGCCATGGCCCTGGCCTCCTGATTGAGAACGCCCAGCCACTGCCCTCTGCTGGAGAGGACCAGGTGCTGCCAGGACTCCACCCGCCGTCC
CTGGCAGACAACCTGAGCCACCGCCCTCTGGCCAACTGCCGCTCTGGGGAGCAGATCTTCACCCAGGACGTGCGGCCAGAACAGCTGCTG
GAGGGGAAGGACGCGCAGGCCATTCATAACTGGCTAAGCGAGTTCCAGCTGGAGGGCTACACTGCCCACTTTCTGCAGGCCGGCTATGAT
GTGCCTACCATCAGCCGCATGACACCTGAGGACCTGACGGCCATCGGGGTGACCAAGCCTGGGCACAGGAAGAAGATCGCCTCAGAGATC
GCTCAGCTCAGCATCGCCGAGTGGCTGCCCAGCTACATCCCAACGGACCTGCTGGAGTGGCTGTGTGCACTGGGGCTGCCACAGTACCAC
AAGCAGCTGGTGAGCAGCGGCTACGACTCCATGGGGCTGGTGGCCGACCTCACCTGGGAGGAGCTGCAGGAGATTGGGGTCAACAAGCTC
GGGCATCAGAAGAAGCTCATGCTGGGGGTGAAGCGGCTGGCGGAGCTTCGGCGGGGCCTGCTGCAGGGGGAGGCCCTCAGCGAAGGCGGG
CGCCGGCTGGCCAAGGGTCCGGAGCTGATGGCCATCGAGGGACTGGAGAACGGAGAAGGCCCAGCTACAGCTGGCCCACGGCTCCTCACC
TTCCAGGGCAGCGAACTAAGCCCAGAGCTACAGGCGGCCATGGCAGGGGGTGGCCCTGAACCACTCCCCCTCCCACCTGCCCGCTCTCCC
AGCCAGGAGAGCATCGGGGCACGCTCACGGGGGTCTGGCCACTCACAGGAACAGCCTGCCCCACAGCCCAGCGGTGGAGATCCCAGCCCC
CCCCAGGAGAGGAACCTCCCAGAGGGCACAGAGCGGCCCCCTAAGCTTTGTTCTTCACTTCCTGGCCAAGGACCCCCACCCTATGTTTTT
ATGTACCCCCAGGGCTCACCCTCTAGCCCGGCCCCAGGGCCACCTCCTGGCGCACCCTGGGCCTTCTCCTACTTGGCCGGGCCCCCTGCC
ACTCCCCCAGACCCGCCTCGACCTAAGCGCCGGTCCCACAGCCTAAGCCGCCCTGGCCCCACAGAGGGGGATGCTGAGGGGGAGGCCGAA
GGGCCAGTGGGCAGCACCCTAGGCAGTTATGCTACCCTTACCCGGCGGCCAGGACGCAGTGCCCTTGTCCGGACCAGTCCTAGTGTGACC
CCAACCCCAGCTCGGGGGACTCCTCGCAGCCAGTCCTTTGCCCTGCGGGCCCGGCGCAAAGGCCCCCCGCCCCCGCCCCCCAAGCGCCTC
AGCTCCGTCTCTGGCCCCAGCCCGGAGCCACCTCCACTAGATGAGAGCCCAGGGCCCAAGGAAGGGGCCACAGGGCCCCGAAGGCGAACA
CTGAGTGAACCTGCTGGCCCCTCAGAGCCCCCTGGCCCACCTGCCCCGGCTGGGCCCGCGTCAGACACGGAGGAGGAGGAGCCAGGCCCT
GAGGGGACGCCCCCATCTCGGGGCAGCTCTGGGGAAGGGCTGCCGTTTGCAGAGGAAGGGAACCTGACCATCAAACAGCGCCCGAAGCCC
GCTGGCCCCCCGCCCCGAGAGACACCCGTGCCCCCCGGCCTCGATTTCAACCTCACGGAATCAGACACTGTTAAGCGGAGGCCCAAGTGC
CGGGAGAGAGAGCCACTGCAGACCGCACTGCTGGCCTTCGGAGTGGCCAGTGCCACGCCTGGCCCCGCTGCCCCACTGCCTTCCCCAACT
CCTGGCGAGTCTCCTCCAGCTTCTAGCCTTCCCCAGCCCGAGCCCAGCAGCCTTCCAGCCCAAGGAGTTCCAACCCCCCTTGCTCCCAGC
CCCGCCATGCAGCCTCCAGTGCCGCCCTGCCCAGGGCCAGGTCTGGAAAGCTCAGCAGCTAGTCGGTGGAATGGGGAGACAGAACCCCCG
GCCGCCCCTGCTGCCCTCCTCAAGGTGCCCGGAGCAGGAACAGCCCCCAAGCCTGTGTCGGTGGCCTGCACCCAGCTGGCATTTTCTGGC
CCTAAGCTAGCGCCCCGGCTCGGCCCCCGCCCAGTGCCTCCTCCACGGCCTGAGAGCACTGGGACTGTGGGCCCAGGCCAGGCCCAGCAG
AGACTGGAGCAGACCAGCTCGTCCCTGGCAGCTGCACTGAGAGCCGCAGAGAAGAGCATTGGCACCAAGGAGCAAGAGGGCACCCCCAGC
GCCTCCACCAAGCACATTCTGGATGACATCAGCACCATGTTCGACGCCCTGGCTGACCAGCTGGACGCCATGCTGGACTGAGCCCTCCAG
CAGTGCCCACTGTGACCTGCCGAAGTCCACTGCCTTTGCCCCAGCACAGAAGAGGCCCCTGCCACCCTAGGGACGGGCCAAGGGCTGGTC
AGGCTGAAGTGCCCCTCCTAGCAGGGCCCCTTCCCACTCAGCCCGCGGCTGTGGGCACCACAGCTCTTGTGGGGCAGCCCACCTTAGAAC
CTGACTAGCGAGGGACCTCCGCTGCATCTCAGCAAAGCCCCTCCCAGGGTTTGATCGATTGAGCAGGACAGCCCTGCTCCTGGACAGGGA
CCCTGGTAAGAGCTCTCTCCTCAGGGAGGAAGTAGGGGTGGGGCTTTGGGGGTGCTTTCTCTGTACCCCCCAGCCCATGTCCCAAGTTGT
GCCAAGGGAATGCCTCTTGCCACCCACCATCCTGCCCAGGCCCTGAGAGGCTGGAGGAGGCGTGTGTCTGGCCGGGCCCCCTCTCCGTAG
GTGTACAGAGGACATGTAAATACACAGCGGTGGTGCCCAGGCAGCTCCTGCCCCCGCCTTCCCTCACTGAGGCAGGGCTAGCAGGGGTGG
GAGGCAGTGGGGTTAACAGATCCCACAAGTCCTAACTTTTCAATTGTAAATGTTATTTTCTAAGCAGAGAGAAATGCATATATTTTAAAT
GGAATTTATTCTATCAACTGCCTGAGAGGACACAATGGGGGAGGGGCTTCGGACCACAGCAGGAGCCCCGACTGCCCACCTGAGGGCAGG
GAGAGCCTGACCCCATTGGCCCAGGCCCTGGCTCTGTAACCATTAACCTCTTCCCCCAACTAACACCAATGAAAACACCATTCCACGTGA

>34639_34639_1_GRB2-CASKIN2_GRB2_chr17_73389632_ENST00000316615_CASKIN2_chr17_73504366_ENST00000321617_length(amino acids)=1169AA_BP=
MGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAA
QYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGI
EINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNV
RAGDVITVLEQHPDGRWKGHIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAPTPLRPGFSRTPQPPAEEPPHPLTYSQLPRVGLS
PDSPAGDRNSVGSEGSVGSIRSAGSGQSSEGTNGHGPGLLIENAQPLPSAGEDQVLPGLHPPSLADNLSHRPLANCRSGEQIFTQDVRPE
QLLEGKDAQAIHNWLSEFQLEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLPSYIPTDLLEWLCALGLP
QYHKQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAELRRGLLQGEALSEGGRRLAKGPELMAIEGLENGEGPATAGPR
LLTFQGSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGTERPPKLCSSLPGQGPPP
YVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSP
SVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEE
PGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLP
SPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLA

--------------------------------------------------------------
>34639_34639_2_GRB2-CASKIN2_GRB2_chr17_73389632_ENST00000316804_CASKIN2_chr17_73504366_ENST00000321617_length(transcript)=4714nt_BP=380nt
GACCGGGCGGCGGCAGCGGCGGCGGCGGCTGTGGCAGAGTCTGTGCCTGTGGCGGTGACGGCGGCGGGAGCAAGCGCTGCCCTCGCAGAG
CAGCCTTGGGGTCGCCGGCCGCTCGCAGCGTTGTGGAGGGGCGGGCCGGACGCTGAGCGGAGCAGCTGCGCCACGGGTGGCATTGTGTGT
CCCAGAGTGCCGGAGCGAGTCCCAGAAGAGAGGCGAGGCTAAGCCCAGAGCGCTGGGTTGCTTCAGCAGGGAAGACTCCCTTCCCCCTGC
TTCAGGCTGCTGAGCACTGAGCAGCGCTCAGAATGGAAGCCATCGCCAAATATGACTTCAAAGCTACTGCAGACGACGAGCTGAGCTTCA
AAAGGGGGGACATCCTCAAGAGCTCCTGGGCTCCACAAAGAGGCTCAACGTGAACTACCAGGATGCTGATGGATTCTCTGCCCTCCACCA
CGCTGCTTTGGGGGGCAGCCTGGAGCTCATAGCCTTGCTGCTAGAGGCTCAGGCCACTGTTGACATCAAGGACAGCAATGGCATGCGCCC
GCTGCACTACGCAGCCTGGCAGGGCCGGCTGGAGCCTGTGAGGCTGCTGCTGCGCGCCTCTGCGGCTGTCAATGCCGCCTCGCTGGACGG
ACAGATCCCCCTGCACCTGGCTGCACAGTATGGACATTATGAGGTGTCAGAAATGCTCCTCCAGCATCAGTCCAACCCATGCCTGGTCAA
CAAGGCCAAGAAGACGCCCCTGGACCTGGCCTGTGAATTTGGCCGACTCAAGGTGGCCCAGCTGCTTCTGAACAGCCACTTATGTGTGGC
ACTGCTGGAGGGTGAGGCCAAAGACCCGTGTGACCCCAACTACACCACGCCCCTGCACTTGGCTGCCAAGAATGGCCACAGAGAAGTCAT
CAGGCAGCTCCTGAGAGCTGGGATCGAGATCAACCGCCAGACCAAGACGGGTACGGCGCTCCACGAGGCCGCACTGTATGGCAAGACCGA
GGTGGTGCGGCTGCTTCTGGAGGGAGGTGTGGACGTGAACATCCGGAATACGTATAACCAGACGGCGCTGGACATAGTGAATCAGTTCAC
CACCTCCCAGGCCAGCCGGGAAATCAAGCAGCTACTGCGGGAGGCCTCAGGGATCCTGAAGGTCCGAGCGCTCAAGGATTTCTGGAACCT
CCACGATCCCACTGCTCTCAATGTCCGGGCAGGGGATGTCATCACGGTGCTAGAACAGCATCCCGACGGCCGCTGGAAGGGCCACATCCA
CGAGAGCCAGAGGGGCACAGACCGCATAGGCTACTTCCCCCCGGGCATTGTCGAGGTGGTCAGCAAGCGGGTGGGCATCCCTGCAGCCCG
CCTCCCCTCCGCACCCACCCCCCTGCGCCCAGGCTTCTCCCGGACACCGCAGCCTCCTGCCGAAGAACCCCCGCACCCTCTTACCTACAG
CCAGCTTCCTCGGGTGGGCCTCAGCCCAGACAGCCCAGCAGGTGACAGGAATAGTGTGGGCAGTGAGGGCAGCGTGGGCAGCATCCGCAG
TGCCGGCAGCGGGCAGAGCTCTGAGGGCACTAATGGCCATGGCCCTGGCCTCCTGATTGAGAACGCCCAGCCACTGCCCTCTGCTGGAGA
GGACCAGGTGCTGCCAGGACTCCACCCGCCGTCCCTGGCAGACAACCTGAGCCACCGCCCTCTGGCCAACTGCCGCTCTGGGGAGCAGAT
CTTCACCCAGGACGTGCGGCCAGAACAGCTGCTGGAGGGGAAGGACGCGCAGGCCATTCATAACTGGCTAAGCGAGTTCCAGCTGGAGGG
CTACACTGCCCACTTTCTGCAGGCCGGCTATGATGTGCCTACCATCAGCCGCATGACACCTGAGGACCTGACGGCCATCGGGGTGACCAA
GCCTGGGCACAGGAAGAAGATCGCCTCAGAGATCGCTCAGCTCAGCATCGCCGAGTGGCTGCCCAGCTACATCCCAACGGACCTGCTGGA
GTGGCTGTGTGCACTGGGGCTGCCACAGTACCACAAGCAGCTGGTGAGCAGCGGCTACGACTCCATGGGGCTGGTGGCCGACCTCACCTG
GGAGGAGCTGCAGGAGATTGGGGTCAACAAGCTCGGGCATCAGAAGAAGCTCATGCTGGGGGTGAAGCGGCTGGCGGAGCTTCGGCGGGG
CCTGCTGCAGGGGGAGGCCCTCAGCGAAGGCGGGCGCCGGCTGGCCAAGGGTCCGGAGCTGATGGCCATCGAGGGACTGGAGAACGGAGA
AGGCCCAGCTACAGCTGGCCCACGGCTCCTCACCTTCCAGGGCAGCGAACTAAGCCCAGAGCTACAGGCGGCCATGGCAGGGGGTGGCCC
TGAACCACTCCCCCTCCCACCTGCCCGCTCTCCCAGCCAGGAGAGCATCGGGGCACGCTCACGGGGGTCTGGCCACTCACAGGAACAGCC
TGCCCCACAGCCCAGCGGTGGAGATCCCAGCCCCCCCCAGGAGAGGAACCTCCCAGAGGGCACAGAGCGGCCCCCTAAGCTTTGTTCTTC
ACTTCCTGGCCAAGGACCCCCACCCTATGTTTTTATGTACCCCCAGGGCTCACCCTCTAGCCCGGCCCCAGGGCCACCTCCTGGCGCACC
CTGGGCCTTCTCCTACTTGGCCGGGCCCCCTGCCACTCCCCCAGACCCGCCTCGACCTAAGCGCCGGTCCCACAGCCTAAGCCGCCCTGG
CCCCACAGAGGGGGATGCTGAGGGGGAGGCCGAAGGGCCAGTGGGCAGCACCCTAGGCAGTTATGCTACCCTTACCCGGCGGCCAGGACG
CAGTGCCCTTGTCCGGACCAGTCCTAGTGTGACCCCAACCCCAGCTCGGGGGACTCCTCGCAGCCAGTCCTTTGCCCTGCGGGCCCGGCG
CAAAGGCCCCCCGCCCCCGCCCCCCAAGCGCCTCAGCTCCGTCTCTGGCCCCAGCCCGGAGCCACCTCCACTAGATGAGAGCCCAGGGCC
CAAGGAAGGGGCCACAGGGCCCCGAAGGCGAACACTGAGTGAACCTGCTGGCCCCTCAGAGCCCCCTGGCCCACCTGCCCCGGCTGGGCC
CGCGTCAGACACGGAGGAGGAGGAGCCAGGCCCTGAGGGGACGCCCCCATCTCGGGGCAGCTCTGGGGAAGGGCTGCCGTTTGCAGAGGA
AGGGAACCTGACCATCAAACAGCGCCCGAAGCCCGCTGGCCCCCCGCCCCGAGAGACACCCGTGCCCCCCGGCCTCGATTTCAACCTCAC
GGAATCAGACACTGTTAAGCGGAGGCCCAAGTGCCGGGAGAGAGAGCCACTGCAGACCGCACTGCTGGCCTTCGGAGTGGCCAGTGCCAC
GCCTGGCCCCGCTGCCCCACTGCCTTCCCCAACTCCTGGCGAGTCTCCTCCAGCTTCTAGCCTTCCCCAGCCCGAGCCCAGCAGCCTTCC
AGCCCAAGGAGTTCCAACCCCCCTTGCTCCCAGCCCCGCCATGCAGCCTCCAGTGCCGCCCTGCCCAGGGCCAGGTCTGGAAAGCTCAGC
AGCTAGTCGGTGGAATGGGGAGACAGAACCCCCGGCCGCCCCTGCTGCCCTCCTCAAGGTGCCCGGAGCAGGAACAGCCCCCAAGCCTGT
GTCGGTGGCCTGCACCCAGCTGGCATTTTCTGGCCCTAAGCTAGCGCCCCGGCTCGGCCCCCGCCCAGTGCCTCCTCCACGGCCTGAGAG
CACTGGGACTGTGGGCCCAGGCCAGGCCCAGCAGAGACTGGAGCAGACCAGCTCGTCCCTGGCAGCTGCACTGAGAGCCGCAGAGAAGAG
CATTGGCACCAAGGAGCAAGAGGGCACCCCCAGCGCCTCCACCAAGCACATTCTGGATGACATCAGCACCATGTTCGACGCCCTGGCTGA
CCAGCTGGACGCCATGCTGGACTGAGCCCTCCAGCAGTGCCCACTGTGACCTGCCGAAGTCCACTGCCTTTGCCCCAGCACAGAAGAGGC
CCCTGCCACCCTAGGGACGGGCCAAGGGCTGGTCAGGCTGAAGTGCCCCTCCTAGCAGGGCCCCTTCCCACTCAGCCCGCGGCTGTGGGC
ACCACAGCTCTTGTGGGGCAGCCCACCTTAGAACCTGACTAGCGAGGGACCTCCGCTGCATCTCAGCAAAGCCCCTCCCAGGGTTTGATC
GATTGAGCAGGACAGCCCTGCTCCTGGACAGGGACCCTGGTAAGAGCTCTCTCCTCAGGGAGGAAGTAGGGGTGGGGCTTTGGGGGTGCT
TTCTCTGTACCCCCCAGCCCATGTCCCAAGTTGTGCCAAGGGAATGCCTCTTGCCACCCACCATCCTGCCCAGGCCCTGAGAGGCTGGAG
GAGGCGTGTGTCTGGCCGGGCCCCCTCTCCGTAGGTGTACAGAGGACATGTAAATACACAGCGGTGGTGCCCAGGCAGCTCCTGCCCCCG
CCTTCCCTCACTGAGGCAGGGCTAGCAGGGGTGGGAGGCAGTGGGGTTAACAGATCCCACAAGTCCTAACTTTTCAATTGTAAATGTTAT
TTTCTAAGCAGAGAGAAATGCATATATTTTAAATGGAATTTATTCTATCAACTGCCTGAGAGGACACAATGGGGGAGGGGCTTCGGACCA
CAGCAGGAGCCCCGACTGCCCACCTGAGGGCAGGGAGAGCCTGACCCCATTGGCCCAGGCCCTGGCTCTGTAACCATTAACCTCTTCCCC

>34639_34639_2_GRB2-CASKIN2_GRB2_chr17_73389632_ENST00000316804_CASKIN2_chr17_73504366_ENST00000321617_length(amino acids)=1169AA_BP=
MGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAA
QYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGI
EINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNV
RAGDVITVLEQHPDGRWKGHIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAPTPLRPGFSRTPQPPAEEPPHPLTYSQLPRVGLS
PDSPAGDRNSVGSEGSVGSIRSAGSGQSSEGTNGHGPGLLIENAQPLPSAGEDQVLPGLHPPSLADNLSHRPLANCRSGEQIFTQDVRPE
QLLEGKDAQAIHNWLSEFQLEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLPSYIPTDLLEWLCALGLP
QYHKQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAELRRGLLQGEALSEGGRRLAKGPELMAIEGLENGEGPATAGPR
LLTFQGSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGTERPPKLCSSLPGQGPPP
YVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSP
SVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEE
PGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLP
SPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLA

--------------------------------------------------------------
>34639_34639_3_GRB2-CASKIN2_GRB2_chr17_73389632_ENST00000392562_CASKIN2_chr17_73504366_ENST00000321617_length(transcript)=5195nt_BP=861nt
GAGTACGGGAGGCTGCGCTCGGCGCCTCTCTCGTGCCTTTTCCTCTTGGCTCTACAGCGGGAGTGGGCCCCGGGGGAACCGGGACCGGCC
CCGGGGTTCGCGTCGGGGCGGCGAGGCTTGGGACGTGGAGCGCAATCCCCGGGGCTCCGGACTCTACGTTTCCCCTTTTGGGGCGCTTCC
TTCCTGGGGACCGTCCTCCTCCGGCTCTTGGCTCTGGGCAGTCCGGGGGAAGAGGTCGGGGTTCTCTGGCGAGGTCCCCTGCCTTCATCG
GGAGGGTTTGCACGGAAGGGGCCCGGGAAGCCCAGGCGGGCCGAACGCCGACCGAGTCAGTCTACCCGAGCCTGGCGGCGGGGGACTGGT
GTGGGCTGCAGCTGTGGTGATTGATGTGCCTTCGACCTGCACGGCAACCACGTCACCATCTCCTGGCGTCTTTGGGCTTAATTTTGTGCG
GGAATCCACTTTGGGGTGGAACGTTTGCTGCTGGAGCCGGGGGAGATACCTTTATTCTGACACTTAAAAAAAAAAACTATTTGAAAAATA
TTTGTCAAGAAAAATTCAGCAGTAGCAGGTTGGACTGCACCGAGGAAGGATTGCGGCGAGAGCGGGCGCTGGTAATTTTCATTTGCAGCG
CGCCCTCTCTATGATTGGTGGCATTGTGTGTCCCAGAGTGCCGGAGCGAGTCCCAGAAGAGAGGCGAGGCTAAGCCCAGAGCGCTGGGTT
GCTTCAGCAGGGAAGACTCCCTTCCCCCTGCTTCAGGCTGCTGAGCACTGAGCAGCGCTCAGAATGGAAGCCATCGCCAAATATGACTTC
AAAGCTACTGCAGACGACGAGCTGAGCTTCAAAAGGGGGGACATCCTCAAGAGCTCCTGGGCTCCACAAAGAGGCTCAACGTGAACTACC
AGGATGCTGATGGATTCTCTGCCCTCCACCACGCTGCTTTGGGGGGCAGCCTGGAGCTCATAGCCTTGCTGCTAGAGGCTCAGGCCACTG
TTGACATCAAGGACAGCAATGGCATGCGCCCGCTGCACTACGCAGCCTGGCAGGGCCGGCTGGAGCCTGTGAGGCTGCTGCTGCGCGCCT
CTGCGGCTGTCAATGCCGCCTCGCTGGACGGACAGATCCCCCTGCACCTGGCTGCACAGTATGGACATTATGAGGTGTCAGAAATGCTCC
TCCAGCATCAGTCCAACCCATGCCTGGTCAACAAGGCCAAGAAGACGCCCCTGGACCTGGCCTGTGAATTTGGCCGACTCAAGGTGGCCC
AGCTGCTTCTGAACAGCCACTTATGTGTGGCACTGCTGGAGGGTGAGGCCAAAGACCCGTGTGACCCCAACTACACCACGCCCCTGCACT
TGGCTGCCAAGAATGGCCACAGAGAAGTCATCAGGCAGCTCCTGAGAGCTGGGATCGAGATCAACCGCCAGACCAAGACGGGTACGGCGC
TCCACGAGGCCGCACTGTATGGCAAGACCGAGGTGGTGCGGCTGCTTCTGGAGGGAGGTGTGGACGTGAACATCCGGAATACGTATAACC
AGACGGCGCTGGACATAGTGAATCAGTTCACCACCTCCCAGGCCAGCCGGGAAATCAAGCAGCTACTGCGGGAGGCCTCAGGGATCCTGA
AGGTCCGAGCGCTCAAGGATTTCTGGAACCTCCACGATCCCACTGCTCTCAATGTCCGGGCAGGGGATGTCATCACGGTGCTAGAACAGC
ATCCCGACGGCCGCTGGAAGGGCCACATCCACGAGAGCCAGAGGGGCACAGACCGCATAGGCTACTTCCCCCCGGGCATTGTCGAGGTGG
TCAGCAAGCGGGTGGGCATCCCTGCAGCCCGCCTCCCCTCCGCACCCACCCCCCTGCGCCCAGGCTTCTCCCGGACACCGCAGCCTCCTG
CCGAAGAACCCCCGCACCCTCTTACCTACAGCCAGCTTCCTCGGGTGGGCCTCAGCCCAGACAGCCCAGCAGGTGACAGGAATAGTGTGG
GCAGTGAGGGCAGCGTGGGCAGCATCCGCAGTGCCGGCAGCGGGCAGAGCTCTGAGGGCACTAATGGCCATGGCCCTGGCCTCCTGATTG
AGAACGCCCAGCCACTGCCCTCTGCTGGAGAGGACCAGGTGCTGCCAGGACTCCACCCGCCGTCCCTGGCAGACAACCTGAGCCACCGCC
CTCTGGCCAACTGCCGCTCTGGGGAGCAGATCTTCACCCAGGACGTGCGGCCAGAACAGCTGCTGGAGGGGAAGGACGCGCAGGCCATTC
ATAACTGGCTAAGCGAGTTCCAGCTGGAGGGCTACACTGCCCACTTTCTGCAGGCCGGCTATGATGTGCCTACCATCAGCCGCATGACAC
CTGAGGACCTGACGGCCATCGGGGTGACCAAGCCTGGGCACAGGAAGAAGATCGCCTCAGAGATCGCTCAGCTCAGCATCGCCGAGTGGC
TGCCCAGCTACATCCCAACGGACCTGCTGGAGTGGCTGTGTGCACTGGGGCTGCCACAGTACCACAAGCAGCTGGTGAGCAGCGGCTACG
ACTCCATGGGGCTGGTGGCCGACCTCACCTGGGAGGAGCTGCAGGAGATTGGGGTCAACAAGCTCGGGCATCAGAAGAAGCTCATGCTGG
GGGTGAAGCGGCTGGCGGAGCTTCGGCGGGGCCTGCTGCAGGGGGAGGCCCTCAGCGAAGGCGGGCGCCGGCTGGCCAAGGGTCCGGAGC
TGATGGCCATCGAGGGACTGGAGAACGGAGAAGGCCCAGCTACAGCTGGCCCACGGCTCCTCACCTTCCAGGGCAGCGAACTAAGCCCAG
AGCTACAGGCGGCCATGGCAGGGGGTGGCCCTGAACCACTCCCCCTCCCACCTGCCCGCTCTCCCAGCCAGGAGAGCATCGGGGCACGCT
CACGGGGGTCTGGCCACTCACAGGAACAGCCTGCCCCACAGCCCAGCGGTGGAGATCCCAGCCCCCCCCAGGAGAGGAACCTCCCAGAGG
GCACAGAGCGGCCCCCTAAGCTTTGTTCTTCACTTCCTGGCCAAGGACCCCCACCCTATGTTTTTATGTACCCCCAGGGCTCACCCTCTA
GCCCGGCCCCAGGGCCACCTCCTGGCGCACCCTGGGCCTTCTCCTACTTGGCCGGGCCCCCTGCCACTCCCCCAGACCCGCCTCGACCTA
AGCGCCGGTCCCACAGCCTAAGCCGCCCTGGCCCCACAGAGGGGGATGCTGAGGGGGAGGCCGAAGGGCCAGTGGGCAGCACCCTAGGCA
GTTATGCTACCCTTACCCGGCGGCCAGGACGCAGTGCCCTTGTCCGGACCAGTCCTAGTGTGACCCCAACCCCAGCTCGGGGGACTCCTC
GCAGCCAGTCCTTTGCCCTGCGGGCCCGGCGCAAAGGCCCCCCGCCCCCGCCCCCCAAGCGCCTCAGCTCCGTCTCTGGCCCCAGCCCGG
AGCCACCTCCACTAGATGAGAGCCCAGGGCCCAAGGAAGGGGCCACAGGGCCCCGAAGGCGAACACTGAGTGAACCTGCTGGCCCCTCAG
AGCCCCCTGGCCCACCTGCCCCGGCTGGGCCCGCGTCAGACACGGAGGAGGAGGAGCCAGGCCCTGAGGGGACGCCCCCATCTCGGGGCA
GCTCTGGGGAAGGGCTGCCGTTTGCAGAGGAAGGGAACCTGACCATCAAACAGCGCCCGAAGCCCGCTGGCCCCCCGCCCCGAGAGACAC
CCGTGCCCCCCGGCCTCGATTTCAACCTCACGGAATCAGACACTGTTAAGCGGAGGCCCAAGTGCCGGGAGAGAGAGCCACTGCAGACCG
CACTGCTGGCCTTCGGAGTGGCCAGTGCCACGCCTGGCCCCGCTGCCCCACTGCCTTCCCCAACTCCTGGCGAGTCTCCTCCAGCTTCTA
GCCTTCCCCAGCCCGAGCCCAGCAGCCTTCCAGCCCAAGGAGTTCCAACCCCCCTTGCTCCCAGCCCCGCCATGCAGCCTCCAGTGCCGC
CCTGCCCAGGGCCAGGTCTGGAAAGCTCAGCAGCTAGTCGGTGGAATGGGGAGACAGAACCCCCGGCCGCCCCTGCTGCCCTCCTCAAGG
TGCCCGGAGCAGGAACAGCCCCCAAGCCTGTGTCGGTGGCCTGCACCCAGCTGGCATTTTCTGGCCCTAAGCTAGCGCCCCGGCTCGGCC
CCCGCCCAGTGCCTCCTCCACGGCCTGAGAGCACTGGGACTGTGGGCCCAGGCCAGGCCCAGCAGAGACTGGAGCAGACCAGCTCGTCCC
TGGCAGCTGCACTGAGAGCCGCAGAGAAGAGCATTGGCACCAAGGAGCAAGAGGGCACCCCCAGCGCCTCCACCAAGCACATTCTGGATG
ACATCAGCACCATGTTCGACGCCCTGGCTGACCAGCTGGACGCCATGCTGGACTGAGCCCTCCAGCAGTGCCCACTGTGACCTGCCGAAG
TCCACTGCCTTTGCCCCAGCACAGAAGAGGCCCCTGCCACCCTAGGGACGGGCCAAGGGCTGGTCAGGCTGAAGTGCCCCTCCTAGCAGG
GCCCCTTCCCACTCAGCCCGCGGCTGTGGGCACCACAGCTCTTGTGGGGCAGCCCACCTTAGAACCTGACTAGCGAGGGACCTCCGCTGC
ATCTCAGCAAAGCCCCTCCCAGGGTTTGATCGATTGAGCAGGACAGCCCTGCTCCTGGACAGGGACCCTGGTAAGAGCTCTCTCCTCAGG
GAGGAAGTAGGGGTGGGGCTTTGGGGGTGCTTTCTCTGTACCCCCCAGCCCATGTCCCAAGTTGTGCCAAGGGAATGCCTCTTGCCACCC
ACCATCCTGCCCAGGCCCTGAGAGGCTGGAGGAGGCGTGTGTCTGGCCGGGCCCCCTCTCCGTAGGTGTACAGAGGACATGTAAATACAC
AGCGGTGGTGCCCAGGCAGCTCCTGCCCCCGCCTTCCCTCACTGAGGCAGGGCTAGCAGGGGTGGGAGGCAGTGGGGTTAACAGATCCCA
CAAGTCCTAACTTTTCAATTGTAAATGTTATTTTCTAAGCAGAGAGAAATGCATATATTTTAAATGGAATTTATTCTATCAACTGCCTGA
GAGGACACAATGGGGGAGGGGCTTCGGACCACAGCAGGAGCCCCGACTGCCCACCTGAGGGCAGGGAGAGCCTGACCCCATTGGCCCAGG

>34639_34639_3_GRB2-CASKIN2_GRB2_chr17_73389632_ENST00000392562_CASKIN2_chr17_73504366_ENST00000321617_length(amino acids)=1169AA_BP=
MGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAA
QYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGI
EINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNV
RAGDVITVLEQHPDGRWKGHIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAPTPLRPGFSRTPQPPAEEPPHPLTYSQLPRVGLS
PDSPAGDRNSVGSEGSVGSIRSAGSGQSSEGTNGHGPGLLIENAQPLPSAGEDQVLPGLHPPSLADNLSHRPLANCRSGEQIFTQDVRPE
QLLEGKDAQAIHNWLSEFQLEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLPSYIPTDLLEWLCALGLP
QYHKQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAELRRGLLQGEALSEGGRRLAKGPELMAIEGLENGEGPATAGPR
LLTFQGSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGTERPPKLCSSLPGQGPPP
YVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSP
SVTPTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEE
PGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLP
SPTPGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLA

--------------------------------------------------------------
>34639_34639_4_GRB2-CASKIN2_GRB2_chr17_73389632_ENST00000392563_CASKIN2_chr17_73502010_ENST00000321617_length(transcript)=3808nt_BP=106nt
GGCTGCTGAGCACTGAGCAGCGCTCAGAATGGAAGCCATCGCCAAATATGACTTCAAAGCTACTGCAGACGACGAGCTGAGCTTCAAAAG
GGGGGACATCCTCAAGGGAGGTGTGGACGTGAACATCCGGAATACGTATAACCAGACGGCGCTGGACATAGTGAATCAGTTCACCACCTC
CCAGGCCAGCCGGGAAATCAAGCAGCTACTGCGGGAGGCCTCAGGGATCCTGAAGGTCCGAGCGCTCAAGGATTTCTGGAACCTCCACGA
TCCCACTGCTCTCAATGTCCGGGCAGGGGATGTCATCACGGTGCTAGAACAGCATCCCGACGGCCGCTGGAAGGGCCACATCCACGAGAG
CCAGAGGGGCACAGACCGCATAGGCTACTTCCCCCCGGGCATTGTCGAGGTGGTCAGCAAGCGGGTGGGCATCCCTGCAGCCCGCCTCCC
CTCCGCACCCACCCCCCTGCGCCCAGGCTTCTCCCGGACACCGCAGCCTCCTGCCGAAGAACCCCCGCACCCTCTTACCTACAGCCAGCT
TCCTCGGGTGGGCCTCAGCCCAGACAGCCCAGCAGGTGACAGGAATAGTGTGGGCAGTGAGGGCAGCGTGGGCAGCATCCGCAGTGCCGG
CAGCGGGCAGAGCTCTGAGGGCACTAATGGCCATGGCCCTGGCCTCCTGATTGAGAACGCCCAGCCACTGCCCTCTGCTGGAGAGGACCA
GGTGCTGCCAGGACTCCACCCGCCGTCCCTGGCAGACAACCTGAGCCACCGCCCTCTGGCCAACTGCCGCTCTGGGGAGCAGATCTTCAC
CCAGGACGTGCGGCCAGAACAGCTGCTGGAGGGGAAGGACGCGCAGGCCATTCATAACTGGCTAAGCGAGTTCCAGCTGGAGGGCTACAC
TGCCCACTTTCTGCAGGCCGGCTATGATGTGCCTACCATCAGCCGCATGACACCTGAGGACCTGACGGCCATCGGGGTGACCAAGCCTGG
GCACAGGAAGAAGATCGCCTCAGAGATCGCTCAGCTCAGCATCGCCGAGTGGCTGCCCAGCTACATCCCAACGGACCTGCTGGAGTGGCT
GTGTGCACTGGGGCTGCCACAGTACCACAAGCAGCTGGTGAGCAGCGGCTACGACTCCATGGGGCTGGTGGCCGACCTCACCTGGGAGGA
GCTGCAGGAGATTGGGGTCAACAAGCTCGGGCATCAGAAGAAGCTCATGCTGGGGGTGAAGCGGCTGGCGGAGCTTCGGCGGGGCCTGCT
GCAGGGGGAGGCCCTCAGCGAAGGCGGGCGCCGGCTGGCCAAGGGTCCGGAGCTGATGGCCATCGAGGGACTGGAGAACGGAGAAGGCCC
AGCTACAGCTGGCCCACGGCTCCTCACCTTCCAGGGCAGCGAACTAAGCCCAGAGCTACAGGCGGCCATGGCAGGGGGTGGCCCTGAACC
ACTCCCCCTCCCACCTGCCCGCTCTCCCAGCCAGGAGAGCATCGGGGCACGCTCACGGGGGTCTGGCCACTCACAGGAACAGCCTGCCCC
ACAGCCCAGCGGTGGAGATCCCAGCCCCCCCCAGGAGAGGAACCTCCCAGAGGGCACAGAGCGGCCCCCTAAGCTTTGTTCTTCACTTCC
TGGCCAAGGACCCCCACCCTATGTTTTTATGTACCCCCAGGGCTCACCCTCTAGCCCGGCCCCAGGGCCACCTCCTGGCGCACCCTGGGC
CTTCTCCTACTTGGCCGGGCCCCCTGCCACTCCCCCAGACCCGCCTCGACCTAAGCGCCGGTCCCACAGCCTAAGCCGCCCTGGCCCCAC
AGAGGGGGATGCTGAGGGGGAGGCCGAAGGGCCAGTGGGCAGCACCCTAGGCAGTTATGCTACCCTTACCCGGCGGCCAGGACGCAGTGC
CCTTGTCCGGACCAGTCCTAGTGTGACCCCAACCCCAGCTCGGGGGACTCCTCGCAGCCAGTCCTTTGCCCTGCGGGCCCGGCGCAAAGG
CCCCCCGCCCCCGCCCCCCAAGCGCCTCAGCTCCGTCTCTGGCCCCAGCCCGGAGCCACCTCCACTAGATGAGAGCCCAGGGCCCAAGGA
AGGGGCCACAGGGCCCCGAAGGCGAACACTGAGTGAACCTGCTGGCCCCTCAGAGCCCCCTGGCCCACCTGCCCCGGCTGGGCCCGCGTC
AGACACGGAGGAGGAGGAGCCAGGCCCTGAGGGGACGCCCCCATCTCGGGGCAGCTCTGGGGAAGGGCTGCCGTTTGCAGAGGAAGGGAA
CCTGACCATCAAACAGCGCCCGAAGCCCGCTGGCCCCCCGCCCCGAGAGACACCCGTGCCCCCCGGCCTCGATTTCAACCTCACGGAATC
AGACACTGTTAAGCGGAGGCCCAAGTGCCGGGAGAGAGAGCCACTGCAGACCGCACTGCTGGCCTTCGGAGTGGCCAGTGCCACGCCTGG
CCCCGCTGCCCCACTGCCTTCCCCAACTCCTGGCGAGTCTCCTCCAGCTTCTAGCCTTCCCCAGCCCGAGCCCAGCAGCCTTCCAGCCCA
AGGAGTTCCAACCCCCCTTGCTCCCAGCCCCGCCATGCAGCCTCCAGTGCCGCCCTGCCCAGGGCCAGGTCTGGAAAGCTCAGCAGCTAG
TCGGTGGAATGGGGAGACAGAACCCCCGGCCGCCCCTGCTGCCCTCCTCAAGGTGCCCGGAGCAGGAACAGCCCCCAAGCCTGTGTCGGT
GGCCTGCACCCAGCTGGCATTTTCTGGCCCTAAGCTAGCGCCCCGGCTCGGCCCCCGCCCAGTGCCTCCTCCACGGCCTGAGAGCACTGG
GACTGTGGGCCCAGGCCAGGCCCAGCAGAGACTGGAGCAGACCAGCTCGTCCCTGGCAGCTGCACTGAGAGCCGCAGAGAAGAGCATTGG
CACCAAGGAGCAAGAGGGCACCCCCAGCGCCTCCACCAAGCACATTCTGGATGACATCAGCACCATGTTCGACGCCCTGGCTGACCAGCT
GGACGCCATGCTGGACTGAGCCCTCCAGCAGTGCCCACTGTGACCTGCCGAAGTCCACTGCCTTTGCCCCAGCACAGAAGAGGCCCCTGC
CACCCTAGGGACGGGCCAAGGGCTGGTCAGGCTGAAGTGCCCCTCCTAGCAGGGCCCCTTCCCACTCAGCCCGCGGCTGTGGGCACCACA
GCTCTTGTGGGGCAGCCCACCTTAGAACCTGACTAGCGAGGGACCTCCGCTGCATCTCAGCAAAGCCCCTCCCAGGGTTTGATCGATTGA
GCAGGACAGCCCTGCTCCTGGACAGGGACCCTGGTAAGAGCTCTCTCCTCAGGGAGGAAGTAGGGGTGGGGCTTTGGGGGTGCTTTCTCT
GTACCCCCCAGCCCATGTCCCAAGTTGTGCCAAGGGAATGCCTCTTGCCACCCACCATCCTGCCCAGGCCCTGAGAGGCTGGAGGAGGCG
TGTGTCTGGCCGGGCCCCCTCTCCGTAGGTGTACAGAGGACATGTAAATACACAGCGGTGGTGCCCAGGCAGCTCCTGCCCCCGCCTTCC
CTCACTGAGGCAGGGCTAGCAGGGGTGGGAGGCAGTGGGGTTAACAGATCCCACAAGTCCTAACTTTTCAATTGTAAATGTTATTTTCTA
AGCAGAGAGAAATGCATATATTTTAAATGGAATTTATTCTATCAACTGCCTGAGAGGACACAATGGGGGAGGGGCTTCGGACCACAGCAG
GAGCCCCGACTGCCCACCTGAGGGCAGGGAGAGCCTGACCCCATTGGCCCAGGCCCTGGCTCTGTAACCATTAACCTCTTCCCCCAACTA

>34639_34639_4_GRB2-CASKIN2_GRB2_chr17_73389632_ENST00000392563_CASKIN2_chr17_73502010_ENST00000321617_length(amino acids)=986AA_BP=26
MEAIAKYDFKATADDELSFKRGDILKGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAG
DVITVLEQHPDGRWKGHIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAPTPLRPGFSRTPQPPAEEPPHPLTYSQLPRVGLSPDS
PAGDRNSVGSEGSVGSIRSAGSGQSSEGTNGHGPGLLIENAQPLPSAGEDQVLPGLHPPSLADNLSHRPLANCRSGEQIFTQDVRPEQLL
EGKDAQAIHNWLSEFQLEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLPSYIPTDLLEWLCALGLPQYH
KQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAELRRGLLQGEALSEGGRRLAKGPELMAIEGLENGEGPATAGPRLLT
FQGSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGTERPPKLCSSLPGQGPPPYVF
MYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVT
PTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGP
EGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPT
PGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSG

--------------------------------------------------------------
>34639_34639_5_GRB2-CASKIN2_GRB2_chr17_73389632_ENST00000392563_CASKIN2_chr17_73502010_ENST00000433559_length(transcript)=3260nt_BP=106nt
GGCTGCTGAGCACTGAGCAGCGCTCAGAATGGAAGCCATCGCCAAATATGACTTCAAAGCTACTGCAGACGACGAGCTGAGCTTCAAAAG
GGGGGACATCCTCAAGGGAGGTGTGGACGTGAACATCCGGAATACGTATAACCAGACGGCGCTGGACATAGTGAATCAGTTCACCACCTC
CCAGGCCAGCCGGGAAATCAAGCAGCTACTGCGGGAGGCCTCAGGGATCCTGAAGGTCCGAGCGCTCAAGGATTTCTGGAACCTCCACGA
TCCCACTGCTCTCAATGTCCGGGCAGGGGATGTCATCACGGTGCTAGAACAGCATCCCGACGGCCGCTGGAAGGGCCACATCCACGAGAG
CCAGAGGGGCACAGACCGCATAGGCTACTTCCCCCCGGGCATTGTCGAGGTGGTCAGCAAGCGGGTGGGCATCCCTGCAGCCCGCCTCCC
CTCCGCACCCACCCCCCTGCGCCCAGGCTTCTCCCGGACACCGCAGCCTCCTGCCGAAGAACCCCCGCACCCTCTTACCTACAGCCAGCT
TCCTCGGGTGGGCCTCAGCCCAGACAGCCCAGCAGGTGACAGGAATAGTGTGGGCAGTGAGGGCAGCGTGGGCAGCATCCGCAGTGCCGG
CAGCGGGCAGAGCTCTGAGGGCACTAATGGCCATGGCCCTGGCCTCCTGATTGAGAACGCCCAGCCACTGCCCTCTGCTGGAGAGGACCA
GGTGCTGCCAGGACTCCACCCGCCGTCCCTGGCAGACAACCTGAGCCACCGCCCTCTGGCCAACTGCCGCTCTGGGGAGCAGATCTTCAC
CCAGGACGTGCGGCCAGAACAGCTGCTGGAGGGGAAGGACGCGCAGGCCATTCATAACTGGCTAAGCGAGTTCCAGCTGGAGGGCTACAC
TGCCCACTTTCTGCAGGCCGGCTATGATGTGCCTACCATCAGCCGCATGACACCTGAGGACCTGACGGCCATCGGGGTGACCAAGCCTGG
GCACAGGAAGAAGATCGCCTCAGAGATCGCTCAGCTCAGCATCGCCGAGTGGCTGCCCAGCTACATCCCAACGGACCTGCTGGAGTGGCT
GTGTGCACTGGGGCTGCCACAGTACCACAAGCAGCTGGTGAGCAGCGGCTACGACTCCATGGGGCTGGTGGCCGACCTCACCTGGGAGGA
GCTGCAGGAGATTGGGGTCAACAAGCTCGGGCATCAGAAGAAGCTCATGCTGGGGGTGAAGCGGCTGGCGGAGCTTCGGCGGGGCCTGCT
GCAGGGGGAGGCCCTCAGCGAAGGCGGGCGCCGGCTGGCCAAGGGTCCGGAGCTGATGGCCATCGAGGGACTGGAGAACGGAGAAGGCCC
AGCTACAGCTGGCCCACGGCTCCTCACCTTCCAGGGCAGCGAACTAAGCCCAGAGCTACAGGCGGCCATGGCAGGGGGTGGCCCTGAACC
ACTCCCCCTCCCACCTGCCCGCTCTCCCAGCCAGGAGAGCATCGGGGCACGCTCACGGGGGTCTGGCCACTCACAGGAACAGCCTGCCCC
ACAGCCCAGCGGTGGAGATCCCAGCCCCCCCCAGGAGAGGAACCTCCCAGAGGGCACAGAGCGGCCCCCTAAGCTTTGTTCTTCACTTCC
TGGCCAAGGACCCCCACCCTATGTTTTTATGTACCCCCAGGGCTCACCCTCTAGCCCGGCCCCAGGGCCACCTCCTGGCGCACCCTGGGC
CTTCTCCTACTTGGCCGGGCCCCCTGCCACTCCCCCAGACCCGCCTCGACCTAAGCGCCGGTCCCACAGCCTAAGCCGCCCTGGCCCCAC
AGAGGGGGATGCTGAGGGGGAGGCCGAAGGGCCAGTGGGCAGCACCCTAGGCAGTTATGCTACCCTTACCCGGCGGCCAGGACGCAGTGC
CCTTGTCCGGACCAGTCCTAGTGTGACCCCAACCCCAGCTCGGGGGACTCCTCGCAGCCAGTCCTTTGCCCTGCGGGCCCGGCGCAAAGG
CCCCCCGCCCCCGCCCCCCAAGCGCCTCAGCTCCGTCTCTGGCCCCAGCCCGGAGCCACCTCCACTAGATGAGAGCCCAGGGCCCAAGGA
AGGGGCCACAGGGCCCCGAAGGCGAACACTGAGTGAACCTGCTGGCCCCTCAGAGCCCCCTGGCCCACCTGCCCCGGCTGGGCCCGCGTC
AGACACGGAGGAGGAGGAGCCAGGCCCTGAGGGGACGCCCCCATCTCGGGGCAGCTCTGGGGAAGGGCTGCCGTTTGCAGAGGAAGGGAA
CCTGACCATCAAACAGCGCCCGAAGCCCGCTGGCCCCCCGCCCCGAGAGACACCCGTGCCCCCCGGCCTCGATTTCAACCTCACGGAATC
AGACACTGTTAAGCGGAGGCCCAAGTGCCGGGAGAGAGAGCCACTGCAGACCGCACTGCTGGCCTTCGGAGTGGCCAGTGCCACGCCTGG
CCCCGCTGCCCCACTGCCTTCCCCAACTCCTGGCGAGTCTCCTCCAGCTTCTAGCCTTCCCCAGCCCGAGCCCAGCAGCCTTCCAGCCCA
AGGAGTTCCAACCCCCCTTGCTCCCAGCCCCGCCATGCAGCCTCCAGTGCCGCCCTGCCCAGGGCCAGGTCTGGAAAGCTCAGCAGCTAG
TCGGTGGAATGGGGAGACAGAACCCCCGGCCGCCCCTGCTGCCCTCCTCAAGGTGCCCGGAGCAGGAACAGCCCCCAAGCCTGTGTCGGT
GGCCTGCACCCAGCTGGCATTTTCTGGCCCTAAGCTAGCGCCCCGGCTCGGCCCCCGCCCAGTGCCTCCTCCACGGCCTGAGAGCACTGG
GACTGTGGGCCCAGGCCAGGCCCAGCAGAGACTGGAGCAGACCAGCTCGTCCCTGGCAGCTGCACTGAGAGCCGCAGAGAAGAGCATTGG
CACCAAGGAGCAAGAGGGCACCCCCAGCGCCTCCACCAAGCACATTCTGGATGACATCAGCACCATGTTCGACGCCCTGGCTGACCAGCT
GGACGCCATGCTGGACTGAGCCCTCCAGCAGTGCCCACTGTGACCTGCCGAAGTCCACTGCCTTTGCCCCAGCACAGAAGAGGCCCCTGC
CACCCTAGGGACGGGCCAAGGGCTGGTCAGGCTGAAGTGCCCCTCCTAGCAGGGCCCCTTCCCACTCAGCCCGCGGCTGTGGGCACCACA
GCTCTTGTGGGGCAGCCCACCTTAGAACCTGACTAGCGAGGGACCTCCGCTGCATCTCAGCAAAGCCCCTCCCAGGGTTTGATCGATTGA

>34639_34639_5_GRB2-CASKIN2_GRB2_chr17_73389632_ENST00000392563_CASKIN2_chr17_73502010_ENST00000433559_length(amino acids)=986AA_BP=26
MEAIAKYDFKATADDELSFKRGDILKGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAG
DVITVLEQHPDGRWKGHIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAPTPLRPGFSRTPQPPAEEPPHPLTYSQLPRVGLSPDS
PAGDRNSVGSEGSVGSIRSAGSGQSSEGTNGHGPGLLIENAQPLPSAGEDQVLPGLHPPSLADNLSHRPLANCRSGEQIFTQDVRPEQLL
EGKDAQAIHNWLSEFQLEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLPSYIPTDLLEWLCALGLPQYH
KQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAELRRGLLQGEALSEGGRRLAKGPELMAIEGLENGEGPATAGPRLLT
FQGSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGTERPPKLCSSLPGQGPPPYVF
MYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVT
PTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGP
EGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPT
PGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSG

--------------------------------------------------------------
>34639_34639_6_GRB2-CASKIN2_GRB2_chr17_73389632_ENST00000392563_CASKIN2_chr17_73502010_ENST00000581870_length(transcript)=548nt_BP=106nt
GGCTGCTGAGCACTGAGCAGCGCTCAGAATGGAAGCCATCGCCAAATATGACTTCAAAGCTACTGCAGACGACGAGCTGAGCTTCAAAAG
GGGGGACATCCTCAAGGGAGGTGTGGACGTGAACATCCGGAATACGTATAACCAGACGGCGCTGGACATAGTGAATCAGTTCACCACCTC
CCAGGCCAGCCGGGAAATCAAGCAGCTACTGCGGGAGGCCTCAGGGATCCTGAAGGTCCGAGCGCTCAAGGATTTCTGGAACCTCCACGA
TCCCACTGCTCTCAATGTCCGGGCAGGGGATGTCATCACGGTGAGGGACCCCAAGCAGGCATTCCTTTGCAAATACAAATGATTGCTGTT
ACTTATTTGGGCACCTGCTATGTTACCACGTTCTGCTCTGAGGTCTCTATATGCACCCTCATTTAATTCTTCTTAAAGCCAGGGAAGGCA
GTGCTGTTAGCATTTCTTCTTTACAGATGACAAAATTGAGAATTAAACAAAATAAAATCAAGAGAAATTCAAGTGACTTGCCCAAGGTCA

>34639_34639_6_GRB2-CASKIN2_GRB2_chr17_73389632_ENST00000392563_CASKIN2_chr17_73502010_ENST00000581870_length(amino acids)=107AA_BP=26
MEAIAKYDFKATADDELSFKRGDILKGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAG

--------------------------------------------------------------
>34639_34639_7_GRB2-CASKIN2_GRB2_chr17_73389632_ENST00000392564_CASKIN2_chr17_73502010_ENST00000321617_length(transcript)=4016nt_BP=314nt
GAGCCAGGGGGCGTGGGGGCTGGGACAGCAGGCCGATTGGCAGGGCGGGGTTGCCTTCAATCCTGGCCACTGCTCTTAATCGTCCCTCTC
CTGCTTCAGGGTGGCATTGTGTGTCCCAGAGTGCCGGAGCGAGTCCCAGAAGAGAGGCGAGGCTAAGCCCAGAGCGCTGGGTTGCTTCAG
CAGGGAAGACTCCCTTCCCCCTGCTTCAGGCTGCTGAGCACTGAGCAGCGCTCAGAATGGAAGCCATCGCCAAATATGACTTCAAAGCTA
CTGCAGACGACGAGCTGAGCTTCAAAAGGGGGGACATCCTCAAGGGAGGTGTGGACGTGAACATCCGGAATACGTATAACCAGACGGCGC
TGGACATAGTGAATCAGTTCACCACCTCCCAGGCCAGCCGGGAAATCAAGCAGCTACTGCGGGAGGCCTCAGGGATCCTGAAGGTCCGAG
CGCTCAAGGATTTCTGGAACCTCCACGATCCCACTGCTCTCAATGTCCGGGCAGGGGATGTCATCACGGTGCTAGAACAGCATCCCGACG
GCCGCTGGAAGGGCCACATCCACGAGAGCCAGAGGGGCACAGACCGCATAGGCTACTTCCCCCCGGGCATTGTCGAGGTGGTCAGCAAGC
GGGTGGGCATCCCTGCAGCCCGCCTCCCCTCCGCACCCACCCCCCTGCGCCCAGGCTTCTCCCGGACACCGCAGCCTCCTGCCGAAGAAC
CCCCGCACCCTCTTACCTACAGCCAGCTTCCTCGGGTGGGCCTCAGCCCAGACAGCCCAGCAGGTGACAGGAATAGTGTGGGCAGTGAGG
GCAGCGTGGGCAGCATCCGCAGTGCCGGCAGCGGGCAGAGCTCTGAGGGCACTAATGGCCATGGCCCTGGCCTCCTGATTGAGAACGCCC
AGCCACTGCCCTCTGCTGGAGAGGACCAGGTGCTGCCAGGACTCCACCCGCCGTCCCTGGCAGACAACCTGAGCCACCGCCCTCTGGCCA
ACTGCCGCTCTGGGGAGCAGATCTTCACCCAGGACGTGCGGCCAGAACAGCTGCTGGAGGGGAAGGACGCGCAGGCCATTCATAACTGGC
TAAGCGAGTTCCAGCTGGAGGGCTACACTGCCCACTTTCTGCAGGCCGGCTATGATGTGCCTACCATCAGCCGCATGACACCTGAGGACC
TGACGGCCATCGGGGTGACCAAGCCTGGGCACAGGAAGAAGATCGCCTCAGAGATCGCTCAGCTCAGCATCGCCGAGTGGCTGCCCAGCT
ACATCCCAACGGACCTGCTGGAGTGGCTGTGTGCACTGGGGCTGCCACAGTACCACAAGCAGCTGGTGAGCAGCGGCTACGACTCCATGG
GGCTGGTGGCCGACCTCACCTGGGAGGAGCTGCAGGAGATTGGGGTCAACAAGCTCGGGCATCAGAAGAAGCTCATGCTGGGGGTGAAGC
GGCTGGCGGAGCTTCGGCGGGGCCTGCTGCAGGGGGAGGCCCTCAGCGAAGGCGGGCGCCGGCTGGCCAAGGGTCCGGAGCTGATGGCCA
TCGAGGGACTGGAGAACGGAGAAGGCCCAGCTACAGCTGGCCCACGGCTCCTCACCTTCCAGGGCAGCGAACTAAGCCCAGAGCTACAGG
CGGCCATGGCAGGGGGTGGCCCTGAACCACTCCCCCTCCCACCTGCCCGCTCTCCCAGCCAGGAGAGCATCGGGGCACGCTCACGGGGGT
CTGGCCACTCACAGGAACAGCCTGCCCCACAGCCCAGCGGTGGAGATCCCAGCCCCCCCCAGGAGAGGAACCTCCCAGAGGGCACAGAGC
GGCCCCCTAAGCTTTGTTCTTCACTTCCTGGCCAAGGACCCCCACCCTATGTTTTTATGTACCCCCAGGGCTCACCCTCTAGCCCGGCCC
CAGGGCCACCTCCTGGCGCACCCTGGGCCTTCTCCTACTTGGCCGGGCCCCCTGCCACTCCCCCAGACCCGCCTCGACCTAAGCGCCGGT
CCCACAGCCTAAGCCGCCCTGGCCCCACAGAGGGGGATGCTGAGGGGGAGGCCGAAGGGCCAGTGGGCAGCACCCTAGGCAGTTATGCTA
CCCTTACCCGGCGGCCAGGACGCAGTGCCCTTGTCCGGACCAGTCCTAGTGTGACCCCAACCCCAGCTCGGGGGACTCCTCGCAGCCAGT
CCTTTGCCCTGCGGGCCCGGCGCAAAGGCCCCCCGCCCCCGCCCCCCAAGCGCCTCAGCTCCGTCTCTGGCCCCAGCCCGGAGCCACCTC
CACTAGATGAGAGCCCAGGGCCCAAGGAAGGGGCCACAGGGCCCCGAAGGCGAACACTGAGTGAACCTGCTGGCCCCTCAGAGCCCCCTG
GCCCACCTGCCCCGGCTGGGCCCGCGTCAGACACGGAGGAGGAGGAGCCAGGCCCTGAGGGGACGCCCCCATCTCGGGGCAGCTCTGGGG
AAGGGCTGCCGTTTGCAGAGGAAGGGAACCTGACCATCAAACAGCGCCCGAAGCCCGCTGGCCCCCCGCCCCGAGAGACACCCGTGCCCC
CCGGCCTCGATTTCAACCTCACGGAATCAGACACTGTTAAGCGGAGGCCCAAGTGCCGGGAGAGAGAGCCACTGCAGACCGCACTGCTGG
CCTTCGGAGTGGCCAGTGCCACGCCTGGCCCCGCTGCCCCACTGCCTTCCCCAACTCCTGGCGAGTCTCCTCCAGCTTCTAGCCTTCCCC
AGCCCGAGCCCAGCAGCCTTCCAGCCCAAGGAGTTCCAACCCCCCTTGCTCCCAGCCCCGCCATGCAGCCTCCAGTGCCGCCCTGCCCAG
GGCCAGGTCTGGAAAGCTCAGCAGCTAGTCGGTGGAATGGGGAGACAGAACCCCCGGCCGCCCCTGCTGCCCTCCTCAAGGTGCCCGGAG
CAGGAACAGCCCCCAAGCCTGTGTCGGTGGCCTGCACCCAGCTGGCATTTTCTGGCCCTAAGCTAGCGCCCCGGCTCGGCCCCCGCCCAG
TGCCTCCTCCACGGCCTGAGAGCACTGGGACTGTGGGCCCAGGCCAGGCCCAGCAGAGACTGGAGCAGACCAGCTCGTCCCTGGCAGCTG
CACTGAGAGCCGCAGAGAAGAGCATTGGCACCAAGGAGCAAGAGGGCACCCCCAGCGCCTCCACCAAGCACATTCTGGATGACATCAGCA
CCATGTTCGACGCCCTGGCTGACCAGCTGGACGCCATGCTGGACTGAGCCCTCCAGCAGTGCCCACTGTGACCTGCCGAAGTCCACTGCC
TTTGCCCCAGCACAGAAGAGGCCCCTGCCACCCTAGGGACGGGCCAAGGGCTGGTCAGGCTGAAGTGCCCCTCCTAGCAGGGCCCCTTCC
CACTCAGCCCGCGGCTGTGGGCACCACAGCTCTTGTGGGGCAGCCCACCTTAGAACCTGACTAGCGAGGGACCTCCGCTGCATCTCAGCA
AAGCCCCTCCCAGGGTTTGATCGATTGAGCAGGACAGCCCTGCTCCTGGACAGGGACCCTGGTAAGAGCTCTCTCCTCAGGGAGGAAGTA
GGGGTGGGGCTTTGGGGGTGCTTTCTCTGTACCCCCCAGCCCATGTCCCAAGTTGTGCCAAGGGAATGCCTCTTGCCACCCACCATCCTG
CCCAGGCCCTGAGAGGCTGGAGGAGGCGTGTGTCTGGCCGGGCCCCCTCTCCGTAGGTGTACAGAGGACATGTAAATACACAGCGGTGGT
GCCCAGGCAGCTCCTGCCCCCGCCTTCCCTCACTGAGGCAGGGCTAGCAGGGGTGGGAGGCAGTGGGGTTAACAGATCCCACAAGTCCTA
ACTTTTCAATTGTAAATGTTATTTTCTAAGCAGAGAGAAATGCATATATTTTAAATGGAATTTATTCTATCAACTGCCTGAGAGGACACA
ATGGGGGAGGGGCTTCGGACCACAGCAGGAGCCCCGACTGCCCACCTGAGGGCAGGGAGAGCCTGACCCCATTGGCCCAGGCCCTGGCTC

>34639_34639_7_GRB2-CASKIN2_GRB2_chr17_73389632_ENST00000392564_CASKIN2_chr17_73502010_ENST00000321617_length(amino acids)=986AA_BP=26
MEAIAKYDFKATADDELSFKRGDILKGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAG
DVITVLEQHPDGRWKGHIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAPTPLRPGFSRTPQPPAEEPPHPLTYSQLPRVGLSPDS
PAGDRNSVGSEGSVGSIRSAGSGQSSEGTNGHGPGLLIENAQPLPSAGEDQVLPGLHPPSLADNLSHRPLANCRSGEQIFTQDVRPEQLL
EGKDAQAIHNWLSEFQLEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLPSYIPTDLLEWLCALGLPQYH
KQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAELRRGLLQGEALSEGGRRLAKGPELMAIEGLENGEGPATAGPRLLT
FQGSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGTERPPKLCSSLPGQGPPPYVF
MYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVT
PTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGP
EGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPT
PGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSG

--------------------------------------------------------------
>34639_34639_8_GRB2-CASKIN2_GRB2_chr17_73389632_ENST00000392564_CASKIN2_chr17_73502010_ENST00000433559_length(transcript)=3468nt_BP=314nt
GAGCCAGGGGGCGTGGGGGCTGGGACAGCAGGCCGATTGGCAGGGCGGGGTTGCCTTCAATCCTGGCCACTGCTCTTAATCGTCCCTCTC
CTGCTTCAGGGTGGCATTGTGTGTCCCAGAGTGCCGGAGCGAGTCCCAGAAGAGAGGCGAGGCTAAGCCCAGAGCGCTGGGTTGCTTCAG
CAGGGAAGACTCCCTTCCCCCTGCTTCAGGCTGCTGAGCACTGAGCAGCGCTCAGAATGGAAGCCATCGCCAAATATGACTTCAAAGCTA
CTGCAGACGACGAGCTGAGCTTCAAAAGGGGGGACATCCTCAAGGGAGGTGTGGACGTGAACATCCGGAATACGTATAACCAGACGGCGC
TGGACATAGTGAATCAGTTCACCACCTCCCAGGCCAGCCGGGAAATCAAGCAGCTACTGCGGGAGGCCTCAGGGATCCTGAAGGTCCGAG
CGCTCAAGGATTTCTGGAACCTCCACGATCCCACTGCTCTCAATGTCCGGGCAGGGGATGTCATCACGGTGCTAGAACAGCATCCCGACG
GCCGCTGGAAGGGCCACATCCACGAGAGCCAGAGGGGCACAGACCGCATAGGCTACTTCCCCCCGGGCATTGTCGAGGTGGTCAGCAAGC
GGGTGGGCATCCCTGCAGCCCGCCTCCCCTCCGCACCCACCCCCCTGCGCCCAGGCTTCTCCCGGACACCGCAGCCTCCTGCCGAAGAAC
CCCCGCACCCTCTTACCTACAGCCAGCTTCCTCGGGTGGGCCTCAGCCCAGACAGCCCAGCAGGTGACAGGAATAGTGTGGGCAGTGAGG
GCAGCGTGGGCAGCATCCGCAGTGCCGGCAGCGGGCAGAGCTCTGAGGGCACTAATGGCCATGGCCCTGGCCTCCTGATTGAGAACGCCC
AGCCACTGCCCTCTGCTGGAGAGGACCAGGTGCTGCCAGGACTCCACCCGCCGTCCCTGGCAGACAACCTGAGCCACCGCCCTCTGGCCA
ACTGCCGCTCTGGGGAGCAGATCTTCACCCAGGACGTGCGGCCAGAACAGCTGCTGGAGGGGAAGGACGCGCAGGCCATTCATAACTGGC
TAAGCGAGTTCCAGCTGGAGGGCTACACTGCCCACTTTCTGCAGGCCGGCTATGATGTGCCTACCATCAGCCGCATGACACCTGAGGACC
TGACGGCCATCGGGGTGACCAAGCCTGGGCACAGGAAGAAGATCGCCTCAGAGATCGCTCAGCTCAGCATCGCCGAGTGGCTGCCCAGCT
ACATCCCAACGGACCTGCTGGAGTGGCTGTGTGCACTGGGGCTGCCACAGTACCACAAGCAGCTGGTGAGCAGCGGCTACGACTCCATGG
GGCTGGTGGCCGACCTCACCTGGGAGGAGCTGCAGGAGATTGGGGTCAACAAGCTCGGGCATCAGAAGAAGCTCATGCTGGGGGTGAAGC
GGCTGGCGGAGCTTCGGCGGGGCCTGCTGCAGGGGGAGGCCCTCAGCGAAGGCGGGCGCCGGCTGGCCAAGGGTCCGGAGCTGATGGCCA
TCGAGGGACTGGAGAACGGAGAAGGCCCAGCTACAGCTGGCCCACGGCTCCTCACCTTCCAGGGCAGCGAACTAAGCCCAGAGCTACAGG
CGGCCATGGCAGGGGGTGGCCCTGAACCACTCCCCCTCCCACCTGCCCGCTCTCCCAGCCAGGAGAGCATCGGGGCACGCTCACGGGGGT
CTGGCCACTCACAGGAACAGCCTGCCCCACAGCCCAGCGGTGGAGATCCCAGCCCCCCCCAGGAGAGGAACCTCCCAGAGGGCACAGAGC
GGCCCCCTAAGCTTTGTTCTTCACTTCCTGGCCAAGGACCCCCACCCTATGTTTTTATGTACCCCCAGGGCTCACCCTCTAGCCCGGCCC
CAGGGCCACCTCCTGGCGCACCCTGGGCCTTCTCCTACTTGGCCGGGCCCCCTGCCACTCCCCCAGACCCGCCTCGACCTAAGCGCCGGT
CCCACAGCCTAAGCCGCCCTGGCCCCACAGAGGGGGATGCTGAGGGGGAGGCCGAAGGGCCAGTGGGCAGCACCCTAGGCAGTTATGCTA
CCCTTACCCGGCGGCCAGGACGCAGTGCCCTTGTCCGGACCAGTCCTAGTGTGACCCCAACCCCAGCTCGGGGGACTCCTCGCAGCCAGT
CCTTTGCCCTGCGGGCCCGGCGCAAAGGCCCCCCGCCCCCGCCCCCCAAGCGCCTCAGCTCCGTCTCTGGCCCCAGCCCGGAGCCACCTC
CACTAGATGAGAGCCCAGGGCCCAAGGAAGGGGCCACAGGGCCCCGAAGGCGAACACTGAGTGAACCTGCTGGCCCCTCAGAGCCCCCTG
GCCCACCTGCCCCGGCTGGGCCCGCGTCAGACACGGAGGAGGAGGAGCCAGGCCCTGAGGGGACGCCCCCATCTCGGGGCAGCTCTGGGG
AAGGGCTGCCGTTTGCAGAGGAAGGGAACCTGACCATCAAACAGCGCCCGAAGCCCGCTGGCCCCCCGCCCCGAGAGACACCCGTGCCCC
CCGGCCTCGATTTCAACCTCACGGAATCAGACACTGTTAAGCGGAGGCCCAAGTGCCGGGAGAGAGAGCCACTGCAGACCGCACTGCTGG
CCTTCGGAGTGGCCAGTGCCACGCCTGGCCCCGCTGCCCCACTGCCTTCCCCAACTCCTGGCGAGTCTCCTCCAGCTTCTAGCCTTCCCC
AGCCCGAGCCCAGCAGCCTTCCAGCCCAAGGAGTTCCAACCCCCCTTGCTCCCAGCCCCGCCATGCAGCCTCCAGTGCCGCCCTGCCCAG
GGCCAGGTCTGGAAAGCTCAGCAGCTAGTCGGTGGAATGGGGAGACAGAACCCCCGGCCGCCCCTGCTGCCCTCCTCAAGGTGCCCGGAG
CAGGAACAGCCCCCAAGCCTGTGTCGGTGGCCTGCACCCAGCTGGCATTTTCTGGCCCTAAGCTAGCGCCCCGGCTCGGCCCCCGCCCAG
TGCCTCCTCCACGGCCTGAGAGCACTGGGACTGTGGGCCCAGGCCAGGCCCAGCAGAGACTGGAGCAGACCAGCTCGTCCCTGGCAGCTG
CACTGAGAGCCGCAGAGAAGAGCATTGGCACCAAGGAGCAAGAGGGCACCCCCAGCGCCTCCACCAAGCACATTCTGGATGACATCAGCA
CCATGTTCGACGCCCTGGCTGACCAGCTGGACGCCATGCTGGACTGAGCCCTCCAGCAGTGCCCACTGTGACCTGCCGAAGTCCACTGCC
TTTGCCCCAGCACAGAAGAGGCCCCTGCCACCCTAGGGACGGGCCAAGGGCTGGTCAGGCTGAAGTGCCCCTCCTAGCAGGGCCCCTTCC
CACTCAGCCCGCGGCTGTGGGCACCACAGCTCTTGTGGGGCAGCCCACCTTAGAACCTGACTAGCGAGGGACCTCCGCTGCATCTCAGCA

>34639_34639_8_GRB2-CASKIN2_GRB2_chr17_73389632_ENST00000392564_CASKIN2_chr17_73502010_ENST00000433559_length(amino acids)=986AA_BP=26
MEAIAKYDFKATADDELSFKRGDILKGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAG
DVITVLEQHPDGRWKGHIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAPTPLRPGFSRTPQPPAEEPPHPLTYSQLPRVGLSPDS
PAGDRNSVGSEGSVGSIRSAGSGQSSEGTNGHGPGLLIENAQPLPSAGEDQVLPGLHPPSLADNLSHRPLANCRSGEQIFTQDVRPEQLL
EGKDAQAIHNWLSEFQLEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLPSYIPTDLLEWLCALGLPQYH
KQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAELRRGLLQGEALSEGGRRLAKGPELMAIEGLENGEGPATAGPRLLT
FQGSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGTERPPKLCSSLPGQGPPPYVF
MYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVT
PTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGP
EGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPT
PGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSG

--------------------------------------------------------------
>34639_34639_9_GRB2-CASKIN2_GRB2_chr17_73389632_ENST00000392564_CASKIN2_chr17_73502010_ENST00000581870_length(transcript)=756nt_BP=314nt
GAGCCAGGGGGCGTGGGGGCTGGGACAGCAGGCCGATTGGCAGGGCGGGGTTGCCTTCAATCCTGGCCACTGCTCTTAATCGTCCCTCTC
CTGCTTCAGGGTGGCATTGTGTGTCCCAGAGTGCCGGAGCGAGTCCCAGAAGAGAGGCGAGGCTAAGCCCAGAGCGCTGGGTTGCTTCAG
CAGGGAAGACTCCCTTCCCCCTGCTTCAGGCTGCTGAGCACTGAGCAGCGCTCAGAATGGAAGCCATCGCCAAATATGACTTCAAAGCTA
CTGCAGACGACGAGCTGAGCTTCAAAAGGGGGGACATCCTCAAGGGAGGTGTGGACGTGAACATCCGGAATACGTATAACCAGACGGCGC
TGGACATAGTGAATCAGTTCACCACCTCCCAGGCCAGCCGGGAAATCAAGCAGCTACTGCGGGAGGCCTCAGGGATCCTGAAGGTCCGAG
CGCTCAAGGATTTCTGGAACCTCCACGATCCCACTGCTCTCAATGTCCGGGCAGGGGATGTCATCACGGTGAGGGACCCCAAGCAGGCAT
TCCTTTGCAAATACAAATGATTGCTGTTACTTATTTGGGCACCTGCTATGTTACCACGTTCTGCTCTGAGGTCTCTATATGCACCCTCAT
TTAATTCTTCTTAAAGCCAGGGAAGGCAGTGCTGTTAGCATTTCTTCTTTACAGATGACAAAATTGAGAATTAAACAAAATAAAATCAAG

>34639_34639_9_GRB2-CASKIN2_GRB2_chr17_73389632_ENST00000392564_CASKIN2_chr17_73502010_ENST00000581870_length(amino acids)=107AA_BP=26
MEAIAKYDFKATADDELSFKRGDILKGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAG

--------------------------------------------------------------
>34639_34639_10_GRB2-CASKIN2_GRB2_chr17_73389632_ENST00000578961_CASKIN2_chr17_73502010_ENST00000321617_length(transcript)=3955nt_BP=253nt
CCTGGCCACTGCTCTTAATCGTCCCTCTCCTGCTTCAGGGTGGCATTGTGTGTCCCAGAGTGCCGGAGCGAGTCCCAGAAGAGAGGCGAG
GCTAAGCCCAGAGCGCTGGGTTGCTTCAGCAGGGAAGACTCCCTTCCCCCTGCTTCAGGCTGCTGAGCACTGAGCAGCGCTCAGAATGGA
AGCCATCGCCAAATATGACTTCAAAGCTACTGCAGACGACGAGCTGAGCTTCAAAAGGGGGGACATCCTCAAGGGAGGTGTGGACGTGAA
CATCCGGAATACGTATAACCAGACGGCGCTGGACATAGTGAATCAGTTCACCACCTCCCAGGCCAGCCGGGAAATCAAGCAGCTACTGCG
GGAGGCCTCAGGGATCCTGAAGGTCCGAGCGCTCAAGGATTTCTGGAACCTCCACGATCCCACTGCTCTCAATGTCCGGGCAGGGGATGT
CATCACGGTGCTAGAACAGCATCCCGACGGCCGCTGGAAGGGCCACATCCACGAGAGCCAGAGGGGCACAGACCGCATAGGCTACTTCCC
CCCGGGCATTGTCGAGGTGGTCAGCAAGCGGGTGGGCATCCCTGCAGCCCGCCTCCCCTCCGCACCCACCCCCCTGCGCCCAGGCTTCTC
CCGGACACCGCAGCCTCCTGCCGAAGAACCCCCGCACCCTCTTACCTACAGCCAGCTTCCTCGGGTGGGCCTCAGCCCAGACAGCCCAGC
AGGTGACAGGAATAGTGTGGGCAGTGAGGGCAGCGTGGGCAGCATCCGCAGTGCCGGCAGCGGGCAGAGCTCTGAGGGCACTAATGGCCA
TGGCCCTGGCCTCCTGATTGAGAACGCCCAGCCACTGCCCTCTGCTGGAGAGGACCAGGTGCTGCCAGGACTCCACCCGCCGTCCCTGGC
AGACAACCTGAGCCACCGCCCTCTGGCCAACTGCCGCTCTGGGGAGCAGATCTTCACCCAGGACGTGCGGCCAGAACAGCTGCTGGAGGG
GAAGGACGCGCAGGCCATTCATAACTGGCTAAGCGAGTTCCAGCTGGAGGGCTACACTGCCCACTTTCTGCAGGCCGGCTATGATGTGCC
TACCATCAGCCGCATGACACCTGAGGACCTGACGGCCATCGGGGTGACCAAGCCTGGGCACAGGAAGAAGATCGCCTCAGAGATCGCTCA
GCTCAGCATCGCCGAGTGGCTGCCCAGCTACATCCCAACGGACCTGCTGGAGTGGCTGTGTGCACTGGGGCTGCCACAGTACCACAAGCA
GCTGGTGAGCAGCGGCTACGACTCCATGGGGCTGGTGGCCGACCTCACCTGGGAGGAGCTGCAGGAGATTGGGGTCAACAAGCTCGGGCA
TCAGAAGAAGCTCATGCTGGGGGTGAAGCGGCTGGCGGAGCTTCGGCGGGGCCTGCTGCAGGGGGAGGCCCTCAGCGAAGGCGGGCGCCG
GCTGGCCAAGGGTCCGGAGCTGATGGCCATCGAGGGACTGGAGAACGGAGAAGGCCCAGCTACAGCTGGCCCACGGCTCCTCACCTTCCA
GGGCAGCGAACTAAGCCCAGAGCTACAGGCGGCCATGGCAGGGGGTGGCCCTGAACCACTCCCCCTCCCACCTGCCCGCTCTCCCAGCCA
GGAGAGCATCGGGGCACGCTCACGGGGGTCTGGCCACTCACAGGAACAGCCTGCCCCACAGCCCAGCGGTGGAGATCCCAGCCCCCCCCA
GGAGAGGAACCTCCCAGAGGGCACAGAGCGGCCCCCTAAGCTTTGTTCTTCACTTCCTGGCCAAGGACCCCCACCCTATGTTTTTATGTA
CCCCCAGGGCTCACCCTCTAGCCCGGCCCCAGGGCCACCTCCTGGCGCACCCTGGGCCTTCTCCTACTTGGCCGGGCCCCCTGCCACTCC
CCCAGACCCGCCTCGACCTAAGCGCCGGTCCCACAGCCTAAGCCGCCCTGGCCCCACAGAGGGGGATGCTGAGGGGGAGGCCGAAGGGCC
AGTGGGCAGCACCCTAGGCAGTTATGCTACCCTTACCCGGCGGCCAGGACGCAGTGCCCTTGTCCGGACCAGTCCTAGTGTGACCCCAAC
CCCAGCTCGGGGGACTCCTCGCAGCCAGTCCTTTGCCCTGCGGGCCCGGCGCAAAGGCCCCCCGCCCCCGCCCCCCAAGCGCCTCAGCTC
CGTCTCTGGCCCCAGCCCGGAGCCACCTCCACTAGATGAGAGCCCAGGGCCCAAGGAAGGGGCCACAGGGCCCCGAAGGCGAACACTGAG
TGAACCTGCTGGCCCCTCAGAGCCCCCTGGCCCACCTGCCCCGGCTGGGCCCGCGTCAGACACGGAGGAGGAGGAGCCAGGCCCTGAGGG
GACGCCCCCATCTCGGGGCAGCTCTGGGGAAGGGCTGCCGTTTGCAGAGGAAGGGAACCTGACCATCAAACAGCGCCCGAAGCCCGCTGG
CCCCCCGCCCCGAGAGACACCCGTGCCCCCCGGCCTCGATTTCAACCTCACGGAATCAGACACTGTTAAGCGGAGGCCCAAGTGCCGGGA
GAGAGAGCCACTGCAGACCGCACTGCTGGCCTTCGGAGTGGCCAGTGCCACGCCTGGCCCCGCTGCCCCACTGCCTTCCCCAACTCCTGG
CGAGTCTCCTCCAGCTTCTAGCCTTCCCCAGCCCGAGCCCAGCAGCCTTCCAGCCCAAGGAGTTCCAACCCCCCTTGCTCCCAGCCCCGC
CATGCAGCCTCCAGTGCCGCCCTGCCCAGGGCCAGGTCTGGAAAGCTCAGCAGCTAGTCGGTGGAATGGGGAGACAGAACCCCCGGCCGC
CCCTGCTGCCCTCCTCAAGGTGCCCGGAGCAGGAACAGCCCCCAAGCCTGTGTCGGTGGCCTGCACCCAGCTGGCATTTTCTGGCCCTAA
GCTAGCGCCCCGGCTCGGCCCCCGCCCAGTGCCTCCTCCACGGCCTGAGAGCACTGGGACTGTGGGCCCAGGCCAGGCCCAGCAGAGACT
GGAGCAGACCAGCTCGTCCCTGGCAGCTGCACTGAGAGCCGCAGAGAAGAGCATTGGCACCAAGGAGCAAGAGGGCACCCCCAGCGCCTC
CACCAAGCACATTCTGGATGACATCAGCACCATGTTCGACGCCCTGGCTGACCAGCTGGACGCCATGCTGGACTGAGCCCTCCAGCAGTG
CCCACTGTGACCTGCCGAAGTCCACTGCCTTTGCCCCAGCACAGAAGAGGCCCCTGCCACCCTAGGGACGGGCCAAGGGCTGGTCAGGCT
GAAGTGCCCCTCCTAGCAGGGCCCCTTCCCACTCAGCCCGCGGCTGTGGGCACCACAGCTCTTGTGGGGCAGCCCACCTTAGAACCTGAC
TAGCGAGGGACCTCCGCTGCATCTCAGCAAAGCCCCTCCCAGGGTTTGATCGATTGAGCAGGACAGCCCTGCTCCTGGACAGGGACCCTG
GTAAGAGCTCTCTCCTCAGGGAGGAAGTAGGGGTGGGGCTTTGGGGGTGCTTTCTCTGTACCCCCCAGCCCATGTCCCAAGTTGTGCCAA
GGGAATGCCTCTTGCCACCCACCATCCTGCCCAGGCCCTGAGAGGCTGGAGGAGGCGTGTGTCTGGCCGGGCCCCCTCTCCGTAGGTGTA
CAGAGGACATGTAAATACACAGCGGTGGTGCCCAGGCAGCTCCTGCCCCCGCCTTCCCTCACTGAGGCAGGGCTAGCAGGGGTGGGAGGC
AGTGGGGTTAACAGATCCCACAAGTCCTAACTTTTCAATTGTAAATGTTATTTTCTAAGCAGAGAGAAATGCATATATTTTAAATGGAAT
TTATTCTATCAACTGCCTGAGAGGACACAATGGGGGAGGGGCTTCGGACCACAGCAGGAGCCCCGACTGCCCACCTGAGGGCAGGGAGAG

>34639_34639_10_GRB2-CASKIN2_GRB2_chr17_73389632_ENST00000578961_CASKIN2_chr17_73502010_ENST00000321617_length(amino acids)=986AA_BP=26
MEAIAKYDFKATADDELSFKRGDILKGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAG
DVITVLEQHPDGRWKGHIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAPTPLRPGFSRTPQPPAEEPPHPLTYSQLPRVGLSPDS
PAGDRNSVGSEGSVGSIRSAGSGQSSEGTNGHGPGLLIENAQPLPSAGEDQVLPGLHPPSLADNLSHRPLANCRSGEQIFTQDVRPEQLL
EGKDAQAIHNWLSEFQLEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLPSYIPTDLLEWLCALGLPQYH
KQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAELRRGLLQGEALSEGGRRLAKGPELMAIEGLENGEGPATAGPRLLT
FQGSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGTERPPKLCSSLPGQGPPPYVF
MYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVT
PTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGP
EGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPT
PGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSG

--------------------------------------------------------------
>34639_34639_11_GRB2-CASKIN2_GRB2_chr17_73389632_ENST00000578961_CASKIN2_chr17_73502010_ENST00000433559_length(transcript)=3407nt_BP=253nt
CCTGGCCACTGCTCTTAATCGTCCCTCTCCTGCTTCAGGGTGGCATTGTGTGTCCCAGAGTGCCGGAGCGAGTCCCAGAAGAGAGGCGAG
GCTAAGCCCAGAGCGCTGGGTTGCTTCAGCAGGGAAGACTCCCTTCCCCCTGCTTCAGGCTGCTGAGCACTGAGCAGCGCTCAGAATGGA
AGCCATCGCCAAATATGACTTCAAAGCTACTGCAGACGACGAGCTGAGCTTCAAAAGGGGGGACATCCTCAAGGGAGGTGTGGACGTGAA
CATCCGGAATACGTATAACCAGACGGCGCTGGACATAGTGAATCAGTTCACCACCTCCCAGGCCAGCCGGGAAATCAAGCAGCTACTGCG
GGAGGCCTCAGGGATCCTGAAGGTCCGAGCGCTCAAGGATTTCTGGAACCTCCACGATCCCACTGCTCTCAATGTCCGGGCAGGGGATGT
CATCACGGTGCTAGAACAGCATCCCGACGGCCGCTGGAAGGGCCACATCCACGAGAGCCAGAGGGGCACAGACCGCATAGGCTACTTCCC
CCCGGGCATTGTCGAGGTGGTCAGCAAGCGGGTGGGCATCCCTGCAGCCCGCCTCCCCTCCGCACCCACCCCCCTGCGCCCAGGCTTCTC
CCGGACACCGCAGCCTCCTGCCGAAGAACCCCCGCACCCTCTTACCTACAGCCAGCTTCCTCGGGTGGGCCTCAGCCCAGACAGCCCAGC
AGGTGACAGGAATAGTGTGGGCAGTGAGGGCAGCGTGGGCAGCATCCGCAGTGCCGGCAGCGGGCAGAGCTCTGAGGGCACTAATGGCCA
TGGCCCTGGCCTCCTGATTGAGAACGCCCAGCCACTGCCCTCTGCTGGAGAGGACCAGGTGCTGCCAGGACTCCACCCGCCGTCCCTGGC
AGACAACCTGAGCCACCGCCCTCTGGCCAACTGCCGCTCTGGGGAGCAGATCTTCACCCAGGACGTGCGGCCAGAACAGCTGCTGGAGGG
GAAGGACGCGCAGGCCATTCATAACTGGCTAAGCGAGTTCCAGCTGGAGGGCTACACTGCCCACTTTCTGCAGGCCGGCTATGATGTGCC
TACCATCAGCCGCATGACACCTGAGGACCTGACGGCCATCGGGGTGACCAAGCCTGGGCACAGGAAGAAGATCGCCTCAGAGATCGCTCA
GCTCAGCATCGCCGAGTGGCTGCCCAGCTACATCCCAACGGACCTGCTGGAGTGGCTGTGTGCACTGGGGCTGCCACAGTACCACAAGCA
GCTGGTGAGCAGCGGCTACGACTCCATGGGGCTGGTGGCCGACCTCACCTGGGAGGAGCTGCAGGAGATTGGGGTCAACAAGCTCGGGCA
TCAGAAGAAGCTCATGCTGGGGGTGAAGCGGCTGGCGGAGCTTCGGCGGGGCCTGCTGCAGGGGGAGGCCCTCAGCGAAGGCGGGCGCCG
GCTGGCCAAGGGTCCGGAGCTGATGGCCATCGAGGGACTGGAGAACGGAGAAGGCCCAGCTACAGCTGGCCCACGGCTCCTCACCTTCCA
GGGCAGCGAACTAAGCCCAGAGCTACAGGCGGCCATGGCAGGGGGTGGCCCTGAACCACTCCCCCTCCCACCTGCCCGCTCTCCCAGCCA
GGAGAGCATCGGGGCACGCTCACGGGGGTCTGGCCACTCACAGGAACAGCCTGCCCCACAGCCCAGCGGTGGAGATCCCAGCCCCCCCCA
GGAGAGGAACCTCCCAGAGGGCACAGAGCGGCCCCCTAAGCTTTGTTCTTCACTTCCTGGCCAAGGACCCCCACCCTATGTTTTTATGTA
CCCCCAGGGCTCACCCTCTAGCCCGGCCCCAGGGCCACCTCCTGGCGCACCCTGGGCCTTCTCCTACTTGGCCGGGCCCCCTGCCACTCC
CCCAGACCCGCCTCGACCTAAGCGCCGGTCCCACAGCCTAAGCCGCCCTGGCCCCACAGAGGGGGATGCTGAGGGGGAGGCCGAAGGGCC
AGTGGGCAGCACCCTAGGCAGTTATGCTACCCTTACCCGGCGGCCAGGACGCAGTGCCCTTGTCCGGACCAGTCCTAGTGTGACCCCAAC
CCCAGCTCGGGGGACTCCTCGCAGCCAGTCCTTTGCCCTGCGGGCCCGGCGCAAAGGCCCCCCGCCCCCGCCCCCCAAGCGCCTCAGCTC
CGTCTCTGGCCCCAGCCCGGAGCCACCTCCACTAGATGAGAGCCCAGGGCCCAAGGAAGGGGCCACAGGGCCCCGAAGGCGAACACTGAG
TGAACCTGCTGGCCCCTCAGAGCCCCCTGGCCCACCTGCCCCGGCTGGGCCCGCGTCAGACACGGAGGAGGAGGAGCCAGGCCCTGAGGG
GACGCCCCCATCTCGGGGCAGCTCTGGGGAAGGGCTGCCGTTTGCAGAGGAAGGGAACCTGACCATCAAACAGCGCCCGAAGCCCGCTGG
CCCCCCGCCCCGAGAGACACCCGTGCCCCCCGGCCTCGATTTCAACCTCACGGAATCAGACACTGTTAAGCGGAGGCCCAAGTGCCGGGA
GAGAGAGCCACTGCAGACCGCACTGCTGGCCTTCGGAGTGGCCAGTGCCACGCCTGGCCCCGCTGCCCCACTGCCTTCCCCAACTCCTGG
CGAGTCTCCTCCAGCTTCTAGCCTTCCCCAGCCCGAGCCCAGCAGCCTTCCAGCCCAAGGAGTTCCAACCCCCCTTGCTCCCAGCCCCGC
CATGCAGCCTCCAGTGCCGCCCTGCCCAGGGCCAGGTCTGGAAAGCTCAGCAGCTAGTCGGTGGAATGGGGAGACAGAACCCCCGGCCGC
CCCTGCTGCCCTCCTCAAGGTGCCCGGAGCAGGAACAGCCCCCAAGCCTGTGTCGGTGGCCTGCACCCAGCTGGCATTTTCTGGCCCTAA
GCTAGCGCCCCGGCTCGGCCCCCGCCCAGTGCCTCCTCCACGGCCTGAGAGCACTGGGACTGTGGGCCCAGGCCAGGCCCAGCAGAGACT
GGAGCAGACCAGCTCGTCCCTGGCAGCTGCACTGAGAGCCGCAGAGAAGAGCATTGGCACCAAGGAGCAAGAGGGCACCCCCAGCGCCTC
CACCAAGCACATTCTGGATGACATCAGCACCATGTTCGACGCCCTGGCTGACCAGCTGGACGCCATGCTGGACTGAGCCCTCCAGCAGTG
CCCACTGTGACCTGCCGAAGTCCACTGCCTTTGCCCCAGCACAGAAGAGGCCCCTGCCACCCTAGGGACGGGCCAAGGGCTGGTCAGGCT
GAAGTGCCCCTCCTAGCAGGGCCCCTTCCCACTCAGCCCGCGGCTGTGGGCACCACAGCTCTTGTGGGGCAGCCCACCTTAGAACCTGAC

>34639_34639_11_GRB2-CASKIN2_GRB2_chr17_73389632_ENST00000578961_CASKIN2_chr17_73502010_ENST00000433559_length(amino acids)=986AA_BP=26
MEAIAKYDFKATADDELSFKRGDILKGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAG
DVITVLEQHPDGRWKGHIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAPTPLRPGFSRTPQPPAEEPPHPLTYSQLPRVGLSPDS
PAGDRNSVGSEGSVGSIRSAGSGQSSEGTNGHGPGLLIENAQPLPSAGEDQVLPGLHPPSLADNLSHRPLANCRSGEQIFTQDVRPEQLL
EGKDAQAIHNWLSEFQLEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLPSYIPTDLLEWLCALGLPQYH
KQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGVKRLAELRRGLLQGEALSEGGRRLAKGPELMAIEGLENGEGPATAGPRLLT
FQGSELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPAPQPSGGDPSPPQERNLPEGTERPPKLCSSLPGQGPPPYVF
MYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGSYATLTRRPGRSALVRTSPSVT
PTPARGTPRSQSFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGP
EGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPT
PGESPPASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQLAFSG

--------------------------------------------------------------
>34639_34639_12_GRB2-CASKIN2_GRB2_chr17_73389632_ENST00000578961_CASKIN2_chr17_73502010_ENST00000581870_length(transcript)=695nt_BP=253nt
CCTGGCCACTGCTCTTAATCGTCCCTCTCCTGCTTCAGGGTGGCATTGTGTGTCCCAGAGTGCCGGAGCGAGTCCCAGAAGAGAGGCGAG
GCTAAGCCCAGAGCGCTGGGTTGCTTCAGCAGGGAAGACTCCCTTCCCCCTGCTTCAGGCTGCTGAGCACTGAGCAGCGCTCAGAATGGA
AGCCATCGCCAAATATGACTTCAAAGCTACTGCAGACGACGAGCTGAGCTTCAAAAGGGGGGACATCCTCAAGGGAGGTGTGGACGTGAA
CATCCGGAATACGTATAACCAGACGGCGCTGGACATAGTGAATCAGTTCACCACCTCCCAGGCCAGCCGGGAAATCAAGCAGCTACTGCG
GGAGGCCTCAGGGATCCTGAAGGTCCGAGCGCTCAAGGATTTCTGGAACCTCCACGATCCCACTGCTCTCAATGTCCGGGCAGGGGATGT
CATCACGGTGAGGGACCCCAAGCAGGCATTCCTTTGCAAATACAAATGATTGCTGTTACTTATTTGGGCACCTGCTATGTTACCACGTTC
TGCTCTGAGGTCTCTATATGCACCCTCATTTAATTCTTCTTAAAGCCAGGGAAGGCAGTGCTGTTAGCATTTCTTCTTTACAGATGACAA

>34639_34639_12_GRB2-CASKIN2_GRB2_chr17_73389632_ENST00000578961_CASKIN2_chr17_73502010_ENST00000581870_length(amino acids)=107AA_BP=26
MEAIAKYDFKATADDELSFKRGDILKGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GRB2-CASKIN2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GRB2-CASKIN2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for GRB2-CASKIN2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source