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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AKT1-B2M (FusionGDB2 ID:3464)

Fusion Gene Summary for AKT1-B2M

check button Fusion gene summary
Fusion gene informationFusion gene name: AKT1-B2M
Fusion gene ID: 3464
HgeneTgene
Gene symbol

AKT1

B2M

Gene ID

207

567

Gene nameAKT serine/threonine kinase 1beta-2-microglobulin
SynonymsAKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHAIMD43
Cytomap

14q32.33

15q21.1

Type of geneprotein-codingprotein-coding
DescriptionRAC-alpha serine/threonine-protein kinaseAKT1mPKB alphaRAC-PK-alphaprotein kinase B alphaproto-oncogene c-Aktrac protein kinase alphaserine-threonine protein kinasev-akt murine thymoma viral oncogene homolog 1v-akt murine thymoma viral oncogene-lbeta-2-microglobulinbeta chain of MHC class I moleculesbeta-2-microglobin
Modification date2020032920200329
UniProtAcc

P31749

P61769

Ensembl transtripts involved in fusion geneENST00000349310, ENST00000402615, 
ENST00000407796, ENST00000554581, 
ENST00000554848, ENST00000555528, 
ENST00000544168, ENST00000554192, 
ENST00000554585, ENST00000555458, 
ENST00000559220, ENST00000544417, 
ENST00000558401, ENST00000559916, 
Fusion gene scores* DoF score10 X 6 X 4=24064 X 31 X 17=33728
# samples 1071
** MAII scorelog2(10/240*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(71/33728*10)=-5.56998393724517
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AKT1 [Title/Abstract] AND B2M [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAKT1(105258935)-B2M(45007621), # samples:1
Anticipated loss of major functional domain due to fusion event.AKT1-B2M seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
AKT1-B2M seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
AKT1-B2M seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
AKT1-B2M seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
AKT1-B2M seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAKT1

GO:0001934

positive regulation of protein phosphorylation

19057511

HgeneAKT1

GO:0006468

protein phosphorylation

11994271|14749367|23431171

HgeneAKT1

GO:0007173

epidermal growth factor receptor signaling pathway

20878056

HgeneAKT1

GO:0016310

phosphorylation

20333297

HgeneAKT1

GO:0018105

peptidyl-serine phosphorylation

16139227

HgeneAKT1

GO:0018107

peptidyl-threonine phosphorylation

20605787

HgeneAKT1

GO:0030307

positive regulation of cell growth

19203586

HgeneAKT1

GO:0032079

positive regulation of endodeoxyribonuclease activity

20605787

HgeneAKT1

GO:0033138

positive regulation of peptidyl-serine phosphorylation

19667065

HgeneAKT1

GO:0035556

intracellular signal transduction

14749367

HgeneAKT1

GO:0035655

interleukin-18-mediated signaling pathway

21321938

HgeneAKT1

GO:0043066

negative regulation of apoptotic process

19203586

HgeneAKT1

GO:0043536

positive regulation of blood vessel endothelial cell migration

20011604

HgeneAKT1

GO:0048661

positive regulation of smooth muscle cell proliferation

21321938

HgeneAKT1

GO:0051091

positive regulation of DNA-binding transcription factor activity

19057511

HgeneAKT1

GO:0070141

response to UV-A

18483258

TgeneB2M

GO:0002726

positive regulation of T cell cytokine production

24643698

TgeneB2M

GO:0007611

learning or memory

26147761

TgeneB2M

GO:0050680

negative regulation of epithelial cell proliferation

28213472

TgeneB2M

GO:0050768

negative regulation of neurogenesis

26147761

TgeneB2M

GO:0090647

modulation of age-related behavioral decline

26147761

TgeneB2M

GO:1900121

negative regulation of receptor binding

9465039

TgeneB2M

GO:1990000

amyloid fibril formation

28468825

TgeneB2M

GO:2000774

positive regulation of cellular senescence

28213472

TgeneB2M

GO:2000978

negative regulation of forebrain neuron differentiation

26147761


check buttonFusion gene breakpoints across AKT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across B2M (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4THYMTCGA-X7-A8DFAKT1chr14

105258935

-B2Mchr15

45007621

+


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Fusion Gene ORF analysis for AKT1-B2M

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000349310ENST00000559220AKT1chr14

105258935

-B2Mchr15

45007621

+
5CDS-intronENST00000402615ENST00000559220AKT1chr14

105258935

-B2Mchr15

45007621

+
5CDS-intronENST00000407796ENST00000559220AKT1chr14

105258935

-B2Mchr15

45007621

+
5CDS-intronENST00000554581ENST00000559220AKT1chr14

105258935

-B2Mchr15

45007621

+
5CDS-intronENST00000554848ENST00000559220AKT1chr14

105258935

-B2Mchr15

45007621

+
5CDS-intronENST00000555528ENST00000559220AKT1chr14

105258935

-B2Mchr15

45007621

+
Frame-shiftENST00000349310ENST00000544417AKT1chr14

105258935

-B2Mchr15

45007621

+
Frame-shiftENST00000349310ENST00000558401AKT1chr14

105258935

-B2Mchr15

45007621

+
Frame-shiftENST00000349310ENST00000559916AKT1chr14

105258935

-B2Mchr15

45007621

+
Frame-shiftENST00000402615ENST00000558401AKT1chr14

105258935

-B2Mchr15

45007621

+
Frame-shiftENST00000402615ENST00000559916AKT1chr14

105258935

-B2Mchr15

45007621

+
Frame-shiftENST00000407796ENST00000544417AKT1chr14

105258935

-B2Mchr15

45007621

+
Frame-shiftENST00000407796ENST00000558401AKT1chr14

105258935

-B2Mchr15

45007621

+
Frame-shiftENST00000407796ENST00000559916AKT1chr14

105258935

-B2Mchr15

45007621

+
Frame-shiftENST00000554581ENST00000544417AKT1chr14

105258935

-B2Mchr15

45007621

+
Frame-shiftENST00000554581ENST00000558401AKT1chr14

105258935

-B2Mchr15

45007621

+
Frame-shiftENST00000554581ENST00000559916AKT1chr14

105258935

-B2Mchr15

45007621

+
Frame-shiftENST00000554848ENST00000544417AKT1chr14

105258935

-B2Mchr15

45007621

+
Frame-shiftENST00000554848ENST00000558401AKT1chr14

105258935

-B2Mchr15

45007621

+
Frame-shiftENST00000554848ENST00000559916AKT1chr14

105258935

-B2Mchr15

45007621

+
Frame-shiftENST00000555528ENST00000558401AKT1chr14

105258935

-B2Mchr15

45007621

+
Frame-shiftENST00000555528ENST00000559916AKT1chr14

105258935

-B2Mchr15

45007621

+
In-frameENST00000402615ENST00000544417AKT1chr14

105258935

-B2Mchr15

45007621

+
In-frameENST00000555528ENST00000544417AKT1chr14

105258935

-B2Mchr15

45007621

+
intron-3CDSENST00000544168ENST00000544417AKT1chr14

105258935

-B2Mchr15

45007621

+
intron-3CDSENST00000544168ENST00000558401AKT1chr14

105258935

-B2Mchr15

45007621

+
intron-3CDSENST00000544168ENST00000559916AKT1chr14

105258935

-B2Mchr15

45007621

+
intron-3CDSENST00000554192ENST00000544417AKT1chr14

105258935

-B2Mchr15

45007621

+
intron-3CDSENST00000554192ENST00000558401AKT1chr14

105258935

-B2Mchr15

45007621

+
intron-3CDSENST00000554192ENST00000559916AKT1chr14

105258935

-B2Mchr15

45007621

+
intron-3CDSENST00000554585ENST00000544417AKT1chr14

105258935

-B2Mchr15

45007621

+
intron-3CDSENST00000554585ENST00000558401AKT1chr14

105258935

-B2Mchr15

45007621

+
intron-3CDSENST00000554585ENST00000559916AKT1chr14

105258935

-B2Mchr15

45007621

+
intron-3CDSENST00000555458ENST00000544417AKT1chr14

105258935

-B2Mchr15

45007621

+
intron-3CDSENST00000555458ENST00000558401AKT1chr14

105258935

-B2Mchr15

45007621

+
intron-3CDSENST00000555458ENST00000559916AKT1chr14

105258935

-B2Mchr15

45007621

+
intron-intronENST00000544168ENST00000559220AKT1chr14

105258935

-B2Mchr15

45007621

+
intron-intronENST00000554192ENST00000559220AKT1chr14

105258935

-B2Mchr15

45007621

+
intron-intronENST00000554585ENST00000559220AKT1chr14

105258935

-B2Mchr15

45007621

+
intron-intronENST00000555458ENST00000559220AKT1chr14

105258935

-B2Mchr15

45007621

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000402615AKT1chr14105258935-ENST00000544417B2Mchr1545007621+245715271521616301
ENST00000555528AKT1chr14105258935-ENST00000544417B2Mchr1545007621+1629699259798179

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000402615ENST00000544417AKT1chr14105258935-B2Mchr1545007621+0.6444450.355555
ENST00000555528ENST00000544417AKT1chr14105258935-B2Mchr1545007621+0.413293960.58670604

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Fusion Genomic Features for AKT1-B2M


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
AKT1chr14105258934-B2Mchr1545007620+0.0017367330.9982633
AKT1chr14105258934-B2Mchr1545007620+0.0017367330.9982633

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for AKT1-B2M


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:105258935/chr15:45007621)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AKT1

P31749

B2M

P61769

FUNCTION: AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis (PubMed:15526160, PubMed:11882383, PubMed:21620960, PubMed:21432781). This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates (PubMed:15526160, PubMed:11882383, PubMed:21620960, PubMed:21432781). Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported (PubMed:15526160, PubMed:11882383, PubMed:21620960, PubMed:21432781). AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface (By similarity). Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling (By similarity). Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport (PubMed:11994271). AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity (By similarity). Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven (By similarity). AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase) (PubMed:11154276). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis (PubMed:11154276). AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1 (PubMed:12150915). AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization (PubMed:10358075). In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319' (PubMed:10358075). FOXO3 and FOXO4 are phosphorylated on equivalent sites (PubMed:10358075). AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein) (PubMed:9829964). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1 (PubMed:9829964). AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis (By similarity). Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis (By similarity). Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity (By similarity). The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I) (PubMed:12176338, PubMed:12964941). AKT mediates the antiapoptotic effects of IGF-I (By similarity). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly (PubMed:19934221). May be involved in the regulation of the placental development (By similarity). Phosphorylates STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its: kinase activity, nuclear translocation, autophosphorylation and ability to phosphorylate FOXO3 (PubMed:17726016). Phosphorylates STK3/MST2 at 'Thr-117' and 'Thr-384' leading to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation (PubMed:20086174, PubMed:20231902). Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and ACIN1 and promotes its nuclear translocation (PubMed:19592491). Phosphorylates RAF1 at 'Ser-259' and negatively regulates its activity (PubMed:10576742). Phosphorylation of BAD stimulates its pro-apoptotic activity (PubMed:10926925). Phosphorylates KAT6A at 'Thr-369' and this phosphorylation inhibits the interaction of KAT6A with PML and negatively regulates its acetylation activity towards p53/TP53 (PubMed:23431171). Phosphorylates palladin (PALLD), modulating cytoskeletal organization and cell motility (PubMed:20471940). Phosphorylates prohibitin (PHB), playing an important role in cell metabolism and proliferation (PubMed:18507042). Phosphorylates CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization (PubMed:16982699). These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation (PubMed:16139227). Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation (PubMed:20682768). Phosphorylates PCK1 at 'Ser-90', reducing the binding affinity of PCK1 to oxaloacetate and changing PCK1 into an atypical protein kinase activity using GTP as donor (PubMed:32322062). {ECO:0000250|UniProtKB:P31750, ECO:0000250|UniProtKB:P47196, ECO:0000269|PubMed:10358075, ECO:0000269|PubMed:10576742, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11154276, ECO:0000269|PubMed:11994271, ECO:0000269|PubMed:12150915, ECO:0000269|PubMed:12176338, ECO:0000269|PubMed:12964941, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:16982699, ECO:0000269|PubMed:17726016, ECO:0000269|PubMed:18507042, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:19934221, ECO:0000269|PubMed:20086174, ECO:0000269|PubMed:20231902, ECO:0000269|PubMed:20471940, ECO:0000269|PubMed:20682768, ECO:0000269|PubMed:23431171, ECO:0000269|PubMed:32322062, ECO:0000269|PubMed:9829964, ECO:0000303|PubMed:11882383, ECO:0000303|PubMed:15526160, ECO:0000303|PubMed:21432781, ECO:0000303|PubMed:21620960}.FUNCTION: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553). {ECO:0000269|PubMed:25356553}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneB2Mchr14:105258935chr15:45007621ENST000005584010425_11322498.0DomainNote=Ig-like C1-type
TgeneB2Mchr14:105258935chr15:45007621ENST000005599160325_11322120.0DomainNote=Ig-like C1-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAKT1chr14:105258935chr15:45007621ENST00000349310-315150_40815481.0DomainProtein kinase
HgeneAKT1chr14:105258935chr15:45007621ENST00000349310-315409_48015481.0DomainAGC-kinase C-terminal
HgeneAKT1chr14:105258935chr15:45007621ENST00000349310-3155_10815481.0DomainPH
HgeneAKT1chr14:105258935chr15:45007621ENST00000402615-214150_40815481.0DomainProtein kinase
HgeneAKT1chr14:105258935chr15:45007621ENST00000402615-214409_48015481.0DomainAGC-kinase C-terminal
HgeneAKT1chr14:105258935chr15:45007621ENST00000402615-2145_10815481.0DomainPH
HgeneAKT1chr14:105258935chr15:45007621ENST00000407796-214150_40815481.0DomainProtein kinase
HgeneAKT1chr14:105258935chr15:45007621ENST00000407796-214409_48015481.0DomainAGC-kinase C-terminal
HgeneAKT1chr14:105258935chr15:45007621ENST00000407796-2145_10815481.0DomainPH
HgeneAKT1chr14:105258935chr15:45007621ENST00000554581-113150_40815481.0DomainProtein kinase
HgeneAKT1chr14:105258935chr15:45007621ENST00000554581-113409_48015481.0DomainAGC-kinase C-terminal
HgeneAKT1chr14:105258935chr15:45007621ENST00000554581-1135_10815481.0DomainPH
HgeneAKT1chr14:105258935chr15:45007621ENST00000554848-214150_40815481.0DomainProtein kinase
HgeneAKT1chr14:105258935chr15:45007621ENST00000554848-214409_48015481.0DomainAGC-kinase C-terminal
HgeneAKT1chr14:105258935chr15:45007621ENST00000554848-2145_10815481.0DomainPH
HgeneAKT1chr14:105258935chr15:45007621ENST00000555528-214150_40815481.0DomainProtein kinase
HgeneAKT1chr14:105258935chr15:45007621ENST00000555528-214409_48015481.0DomainAGC-kinase C-terminal
HgeneAKT1chr14:105258935chr15:45007621ENST00000555528-2145_10815481.0DomainPH
HgeneAKT1chr14:105258935chr15:45007621ENST00000349310-315156_16415481.0Nucleotide bindingATP
HgeneAKT1chr14:105258935chr15:45007621ENST00000402615-214156_16415481.0Nucleotide bindingATP
HgeneAKT1chr14:105258935chr15:45007621ENST00000407796-214156_16415481.0Nucleotide bindingATP
HgeneAKT1chr14:105258935chr15:45007621ENST00000554581-113156_16415481.0Nucleotide bindingATP
HgeneAKT1chr14:105258935chr15:45007621ENST00000554848-214156_16415481.0Nucleotide bindingATP
HgeneAKT1chr14:105258935chr15:45007621ENST00000555528-214156_16415481.0Nucleotide bindingATP
HgeneAKT1chr14:105258935chr15:45007621ENST00000349310-31514_1915481.0RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
HgeneAKT1chr14:105258935chr15:45007621ENST00000349310-315228_23015481.0RegionNote=Inhibitor binding
HgeneAKT1chr14:105258935chr15:45007621ENST00000349310-31523_2515481.0RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
HgeneAKT1chr14:105258935chr15:45007621ENST00000402615-21414_1915481.0RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
HgeneAKT1chr14:105258935chr15:45007621ENST00000402615-214228_23015481.0RegionNote=Inhibitor binding
HgeneAKT1chr14:105258935chr15:45007621ENST00000402615-21423_2515481.0RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
HgeneAKT1chr14:105258935chr15:45007621ENST00000407796-21414_1915481.0RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
HgeneAKT1chr14:105258935chr15:45007621ENST00000407796-214228_23015481.0RegionNote=Inhibitor binding
HgeneAKT1chr14:105258935chr15:45007621ENST00000407796-21423_2515481.0RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
HgeneAKT1chr14:105258935chr15:45007621ENST00000554581-11314_1915481.0RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
HgeneAKT1chr14:105258935chr15:45007621ENST00000554581-113228_23015481.0RegionNote=Inhibitor binding
HgeneAKT1chr14:105258935chr15:45007621ENST00000554581-11323_2515481.0RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
HgeneAKT1chr14:105258935chr15:45007621ENST00000554848-21414_1915481.0RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
HgeneAKT1chr14:105258935chr15:45007621ENST00000554848-214228_23015481.0RegionNote=Inhibitor binding
HgeneAKT1chr14:105258935chr15:45007621ENST00000554848-21423_2515481.0RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
HgeneAKT1chr14:105258935chr15:45007621ENST00000555528-21414_1915481.0RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
HgeneAKT1chr14:105258935chr15:45007621ENST00000555528-214228_23015481.0RegionNote=Inhibitor binding
HgeneAKT1chr14:105258935chr15:45007621ENST00000555528-21423_2515481.0RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding


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Fusion Gene Sequence for AKT1-B2M


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3464_3464_1_AKT1-B2M_AKT1_chr14_105258935_ENST00000402615_B2M_chr15_45007621_ENST00000544417_length(transcript)=2457nt_BP=1527nt
AAGAATATGTGCTTATGGTAAAGGCAGGCGGCAGGTACGGAGGCTGTGGGAAGTCGGGGTCCCTCCGCCCCCACAGGCAGCCCTGTGCTG
GCCTGGTGTATACGTTTCTGTGCAGACGTACACCACCCTGTGTGAGCACAGATGTATTTTTACACATGGCTCTGGACAGCTGTCTGACTC
TGTCAGCAGCAGGCCTTGGAGGGGCTCAGGCCCGTGTGGGGGTGGGGGGACATCCAGAGGTCTTTGAGTCCAGCCCTCTGCCTCCAGGCC
ACGCCCACTCAGTGTCGTCAGAGCCCCCTGTGCCTGAGGCGTGCGCGGCTCGGAGCCCTGCCCTCGGAGTCCTGCGGTGCCTTCCTCGAG
TCTGGCCTGCTTTCCATCCTGCTAAGTACTTGGGGCATTTCCCTCTTTGGGTAAGGTGTGGTCTTCCCTGTCCTGGCATTAGACACAAGG
CAGTGGGCCTTCCTGCCATTCTAAGTGTAGCTTAAGACAATCAGTGCAAAGCAACCCTTTGTGGGTGTCCAGCCCTTGCCTCGGGAGGCC
AGAAAGGTGGCCTGGGGGGAGAGCGTCTAAGCTGGCTGTGGAAAGACCCATGTTGGGATCCATTCCACAGAGGTCGTCAGGGGTCTCTGC
CTGGCCTGGAGGTCCCAGAGAGGACCCTCCTCCCCTCAGGAAGGCCCATCTGGAAGGGTAGCAGAGGACTGCTCACAGGAAGAGCATGCG
AAGTGCTCTTTCTGGGGATGCCTGTAGTTGGTGATGTGGGAACTGGGTTTTGAGGGATGCCTAGGAGTTCATCCATCAGAGGGGAAATGA
GGAAGCCATGCAGGATCAATGGATAAAGTGTGCTCAGGTGAGGGTTGGCTGGTGGGCCGCTGCAGGGCGGGGGCCTGTCCAGTGCTCCCC
CACTTACTTGCTGCCTCCCGACTGCTGTAATTATGGGTCTGTAACCACCCTGGACTGGGTGCTCCTCACTGACGGACTTGTCTGAACCTC
TCTTTGTCTCCAGCGCCCAGCACTGGGCCTGGCAAAACCTGAGACGCCCGGTACATGTTGGCCAAATGAATGAACCAGATTCAGACCGGC
AGGGGCGCTGTGGTTTAGGAGGGGCCTGGGGTTTCTCCCAGGAGGTTTTTGGGCTTGCGCTGGAGGGCTCTGGACTCCCGTTTGCGCCAG
TGGCCTGCATCCTGGTCCTGTCTTCCTCATGTTTGAATTTCTTTGCTTTCCTAGTCTGGGGAGCAGGGAGGAGCCCTGTGCCCTGTCCCA
GGATCCATGGGTAGGAACACCATGGACAGGGAGAGCAAACGGGGCCATCTGTCACCAGGGGCTTAGGGAAGGCCGAGCCAGCCTGGGTCA
AAGAAGTCAAAGGGGCTGCCTGGAGGAGGCAGCCTGTCAGCTGGTGCATCAGAGGCTGTGGCCAGGCCAGCTGGGCTCGGGGAGCGCCAG
CCTGAGAGGAGCGCGTGAGCGTCGCGGGAGCCTCGGGCACCATGAGCGACGTGGCTATTGTGAAGGAGGGTTGGCTGCACAAACGAGGTA
CTCCAAAGATTCAGGTTTACTCACGTCATCCAGCAGAGAATGGAAAGTCAAATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCCG
ACATTGAAGTTGACTTACTGAAGAATGGAGAGAGAATTGAAAAAGTGGAGCATTCAGACTTGTCTTTCAGCAAGGACTGGTCTTTCTATC
TCTTGTACTACACTGAATTCACCCCCACTGAAAAAGATGAGTATGCCTGCCGTGTGAACCATGTGACTTTGTCACAGCCCAAGATAGTTA
AGTGGGGTAAGTCTTACATTCTTTTGTAAGCTGCTGAAAGTTGTGTATGAGTAGTCATATCATAAAGCTGCTTTGATATAAAAAAGGTCT
ATGGCCATACTACCCTGAATGAGTCCCATCCCATCTGATATAAACAATCTGCATATTGGGATTGTCAGGGAATGTTCTTAAAGATCAGAT
TAGTGGCACCTGCTGAGATACTGATGCACAGCATGGTTTCTGAACCAGTAGTTTCCCTGCAGTTGAGCAGGGAGCAGCAGCAGCACTTGC
ACAAATACATATACACTCTTAACACTTCTTACCTACTGGCTTCCTCTAGCTTTTGTGGCAGCTTCAGGTATATTTAGCACTGAACGAACA
TCTCAAGAAGGTATAGGCCTTTGTTTGTAAGTCCTGCTGTCCTAGCATCCTATAATCCTGGACTTCTCCAGTACTTTCTGGCTGGATTGG
TATCTGAGGCTAGTAGGAAGGGCTTGTTCCTGCTGGGTAGCTCTAAACAATGTATTCATGGGTAGGAACAGCAGCCTATTCTGCCAGCCT
TATTTCTAACCATTTTAGACATTTGTTAGTACATGGTATTTTAAAAGTAAAACTTAATGTCTTCCTTTTTTTTCTCCACTGTCTTTTTCA

>3464_3464_1_AKT1-B2M_AKT1_chr14_105258935_ENST00000402615_B2M_chr15_45007621_ENST00000544417_length(amino acids)=301AA_BP=
MCSQPSFTIATSLMVPEAPATLTRSSQAGAPRAQLAWPQPLMHQLTGCLLQAAPLTSLTQAGSAFPKPLVTDGPVCSPCPWCSYPWILGQ
GTGLLPAPQTRKAKKFKHEEDRTRMQATGANGSPEPSSASPKTSWEKPQAPPKPQRPCRSESGSFIWPTCTGRLRFCQAQCWALETKRGS
DKSVSEEHPVQGGYRPIITAVGRQQVSGGALDRPPPCSGPPANPHLSTLYPLILHGFLISPLMDELLGIPQNPVPTSPTTGIPRKSTSHA

--------------------------------------------------------------
>3464_3464_2_AKT1-B2M_AKT1_chr14_105258935_ENST00000555528_B2M_chr15_45007621_ENST00000544417_length(transcript)=1629nt_BP=699nt
ATGGATAAAGTGTGCTCAGGTGAGGGTTGGCTGGTGGGCCGCTGCAGGGCGGGGGCCTGTCCAGTGCTCCCCCACTTACTTGCTGCCTCC
CGACTGCTGTAATTATGGGTCTGTAACCACCCTGGACTGGGTGCTCCTCACTGACGGACTTGTCTGAACCTCTCTTTGTCTCCAGCGCCC
AGCACTGGGCCTGGCAAAACCTGAGACGCCCGGTACATGTTGGCCAAATGAATGAACCAGATTCAGACCGGCAGGGGCGCTGTGGTTTAG
GAGGGGCCTGGGGTTTCTCCCAGGAGGTTTTTGGGCTTGCGCTGGAGGGCTCTGGACTCCCGTTTGCGCCAGTGGCCTGCATCCTGGTCC
TGTCTTCCTCATGTTTGAATTTCTTTGCTTTCCTAGTCTGGGGAGCAGGGAGGAGCCCTGTGCCCTGTCCCAGGATCCATGGGTAGGAAC
ACCATGGACAGGGAGAGCAAACGGGGCCATCTGTCACCAGGGGCTTAGGGAAGGCCGAGCCAGCCTGGGTCAAAGAAGTCAAAGGGGCTG
CCTGGAGGAGGCAGCCTGTCAGCTGGTGCATCAGAGGCTGTGGCCAGGCCAGCTGGGCTCGGGGAGCGCCAGCCTGAGAGGAGCGCGTGA
GCGTCGCGGGAGCCTCGGGCACCATGAGCGACGTGGCTATTGTGAAGGAGGGTTGGCTGCACAAACGAGGTACTCCAAAGATTCAGGTTT
ACTCACGTCATCCAGCAGAGAATGGAAAGTCAAATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCCGACATTGAAGTTGACTTAC
TGAAGAATGGAGAGAGAATTGAAAAAGTGGAGCATTCAGACTTGTCTTTCAGCAAGGACTGGTCTTTCTATCTCTTGTACTACACTGAAT
TCACCCCCACTGAAAAAGATGAGTATGCCTGCCGTGTGAACCATGTGACTTTGTCACAGCCCAAGATAGTTAAGTGGGGTAAGTCTTACA
TTCTTTTGTAAGCTGCTGAAAGTTGTGTATGAGTAGTCATATCATAAAGCTGCTTTGATATAAAAAAGGTCTATGGCCATACTACCCTGA
ATGAGTCCCATCCCATCTGATATAAACAATCTGCATATTGGGATTGTCAGGGAATGTTCTTAAAGATCAGATTAGTGGCACCTGCTGAGA
TACTGATGCACAGCATGGTTTCTGAACCAGTAGTTTCCCTGCAGTTGAGCAGGGAGCAGCAGCAGCACTTGCACAAATACATATACACTC
TTAACACTTCTTACCTACTGGCTTCCTCTAGCTTTTGTGGCAGCTTCAGGTATATTTAGCACTGAACGAACATCTCAAGAAGGTATAGGC
CTTTGTTTGTAAGTCCTGCTGTCCTAGCATCCTATAATCCTGGACTTCTCCAGTACTTTCTGGCTGGATTGGTATCTGAGGCTAGTAGGA
AGGGCTTGTTCCTGCTGGGTAGCTCTAAACAATGTATTCATGGGTAGGAACAGCAGCCTATTCTGCCAGCCTTATTTCTAACCATTTTAG
ACATTTGTTAGTACATGGTATTTTAAAAGTAAAACTTAATGTCTTCCTTTTTTTTCTCCACTGTCTTTTTCATAGATCGAGACATGTAAG

>3464_3464_2_AKT1-B2M_AKT1_chr14_105258935_ENST00000555528_B2M_chr15_45007621_ENST00000544417_length(amino acids)=179AA_BP=146
MWFRRGLGFLPGGFWACAGGLWTPVCASGLHPGPVFLMFEFLCFPSLGSREEPCALSQDPWVGTPWTGRANGAICHQGLREGRASLGQRS

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Fusion Gene PPI Analysis for AKT1-B2M


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AKT1-B2M


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AKT1-B2M


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource