FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:AKT1-ITPK1 (FusionGDB2 ID:3466)

Fusion Gene Summary for AKT1-ITPK1

check button Fusion gene summary
Fusion gene informationFusion gene name: AKT1-ITPK1
Fusion gene ID: 3466
HgeneTgene
Gene symbol

AKT1

ITPK1

Gene ID

207

3705

Gene nameAKT serine/threonine kinase 1inositol-tetrakisphosphate 1-kinase
SynonymsAKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHAITRPK1
Cytomap

14q32.33

14q32.12

Type of geneprotein-codingprotein-coding
DescriptionRAC-alpha serine/threonine-protein kinaseAKT1mPKB alphaRAC-PK-alphaprotein kinase B alphaproto-oncogene c-Aktrac protein kinase alphaserine-threonine protein kinasev-akt murine thymoma viral oncogene homolog 1v-akt murine thymoma viral oncogene-linositol-tetrakisphosphate 1-kinaseinositol 1,3,4-trisphosphate 5/6-kinaseins(1,3,4)P(3) 5/6-kinase
Modification date2020032920200313
UniProtAcc

P31749

Q13572

Ensembl transtripts involved in fusion geneENST00000349310, ENST00000402615, 
ENST00000407796, ENST00000554581, 
ENST00000554848, ENST00000555528, 
ENST00000544168, ENST00000554192, 
ENST00000554585, ENST00000555458, 
ENST00000555495, ENST00000556954, 
ENST00000267615, ENST00000354313, 
ENST00000556603, 
Fusion gene scores* DoF score10 X 6 X 4=2409 X 8 X 7=504
# samples 108
** MAII scorelog2(10/240*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/504*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AKT1 [Title/Abstract] AND ITPK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAKT1(105258935)-ITPK1(93542964), # samples:1
Anticipated loss of major functional domain due to fusion event.AKT1-ITPK1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
AKT1-ITPK1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
AKT1-ITPK1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
AKT1-ITPK1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
AKT1-ITPK1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
AKT1-ITPK1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAKT1

GO:0001934

positive regulation of protein phosphorylation

19057511

HgeneAKT1

GO:0006468

protein phosphorylation

11994271|14749367|23431171

HgeneAKT1

GO:0007173

epidermal growth factor receptor signaling pathway

20878056

HgeneAKT1

GO:0016310

phosphorylation

20333297

HgeneAKT1

GO:0018105

peptidyl-serine phosphorylation

16139227

HgeneAKT1

GO:0018107

peptidyl-threonine phosphorylation

20605787

HgeneAKT1

GO:0030307

positive regulation of cell growth

19203586

HgeneAKT1

GO:0032079

positive regulation of endodeoxyribonuclease activity

20605787

HgeneAKT1

GO:0033138

positive regulation of peptidyl-serine phosphorylation

19667065

HgeneAKT1

GO:0035556

intracellular signal transduction

14749367

HgeneAKT1

GO:0035655

interleukin-18-mediated signaling pathway

21321938

HgeneAKT1

GO:0043066

negative regulation of apoptotic process

19203586

HgeneAKT1

GO:0043536

positive regulation of blood vessel endothelial cell migration

20011604

HgeneAKT1

GO:0048661

positive regulation of smooth muscle cell proliferation

21321938

HgeneAKT1

GO:0051091

positive regulation of DNA-binding transcription factor activity

19057511

HgeneAKT1

GO:0070141

response to UV-A

18483258


check buttonFusion gene breakpoints across AKT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ITPK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GN-01AAKT1chr14

105258935

-ITPK1chr14

93542964

-


Top

Fusion Gene ORF analysis for AKT1-ITPK1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000349310ENST00000555495AKT1chr14

105258935

-ITPK1chr14

93542964

-
5CDS-intronENST00000349310ENST00000556954AKT1chr14

105258935

-ITPK1chr14

93542964

-
5CDS-intronENST00000402615ENST00000555495AKT1chr14

105258935

-ITPK1chr14

93542964

-
5CDS-intronENST00000402615ENST00000556954AKT1chr14

105258935

-ITPK1chr14

93542964

-
5CDS-intronENST00000407796ENST00000555495AKT1chr14

105258935

-ITPK1chr14

93542964

-
5CDS-intronENST00000407796ENST00000556954AKT1chr14

105258935

-ITPK1chr14

93542964

-
5CDS-intronENST00000554581ENST00000555495AKT1chr14

105258935

-ITPK1chr14

93542964

-
5CDS-intronENST00000554581ENST00000556954AKT1chr14

105258935

-ITPK1chr14

93542964

-
5CDS-intronENST00000554848ENST00000555495AKT1chr14

105258935

-ITPK1chr14

93542964

-
5CDS-intronENST00000554848ENST00000556954AKT1chr14

105258935

-ITPK1chr14

93542964

-
5CDS-intronENST00000555528ENST00000555495AKT1chr14

105258935

-ITPK1chr14

93542964

-
5CDS-intronENST00000555528ENST00000556954AKT1chr14

105258935

-ITPK1chr14

93542964

-
Frame-shiftENST00000349310ENST00000267615AKT1chr14

105258935

-ITPK1chr14

93542964

-
Frame-shiftENST00000349310ENST00000354313AKT1chr14

105258935

-ITPK1chr14

93542964

-
Frame-shiftENST00000349310ENST00000556603AKT1chr14

105258935

-ITPK1chr14

93542964

-
Frame-shiftENST00000407796ENST00000267615AKT1chr14

105258935

-ITPK1chr14

93542964

-
Frame-shiftENST00000407796ENST00000354313AKT1chr14

105258935

-ITPK1chr14

93542964

-
Frame-shiftENST00000407796ENST00000556603AKT1chr14

105258935

-ITPK1chr14

93542964

-
Frame-shiftENST00000554581ENST00000267615AKT1chr14

105258935

-ITPK1chr14

93542964

-
Frame-shiftENST00000554581ENST00000354313AKT1chr14

105258935

-ITPK1chr14

93542964

-
Frame-shiftENST00000554581ENST00000556603AKT1chr14

105258935

-ITPK1chr14

93542964

-
Frame-shiftENST00000554848ENST00000267615AKT1chr14

105258935

-ITPK1chr14

93542964

-
Frame-shiftENST00000554848ENST00000354313AKT1chr14

105258935

-ITPK1chr14

93542964

-
Frame-shiftENST00000554848ENST00000556603AKT1chr14

105258935

-ITPK1chr14

93542964

-
In-frameENST00000402615ENST00000267615AKT1chr14

105258935

-ITPK1chr14

93542964

-
In-frameENST00000402615ENST00000354313AKT1chr14

105258935

-ITPK1chr14

93542964

-
In-frameENST00000402615ENST00000556603AKT1chr14

105258935

-ITPK1chr14

93542964

-
In-frameENST00000555528ENST00000267615AKT1chr14

105258935

-ITPK1chr14

93542964

-
In-frameENST00000555528ENST00000354313AKT1chr14

105258935

-ITPK1chr14

93542964

-
In-frameENST00000555528ENST00000556603AKT1chr14

105258935

-ITPK1chr14

93542964

-
intron-3CDSENST00000544168ENST00000267615AKT1chr14

105258935

-ITPK1chr14

93542964

-
intron-3CDSENST00000544168ENST00000354313AKT1chr14

105258935

-ITPK1chr14

93542964

-
intron-3CDSENST00000544168ENST00000556603AKT1chr14

105258935

-ITPK1chr14

93542964

-
intron-3CDSENST00000554192ENST00000267615AKT1chr14

105258935

-ITPK1chr14

93542964

-
intron-3CDSENST00000554192ENST00000354313AKT1chr14

105258935

-ITPK1chr14

93542964

-
intron-3CDSENST00000554192ENST00000556603AKT1chr14

105258935

-ITPK1chr14

93542964

-
intron-3CDSENST00000554585ENST00000267615AKT1chr14

105258935

-ITPK1chr14

93542964

-
intron-3CDSENST00000554585ENST00000354313AKT1chr14

105258935

-ITPK1chr14

93542964

-
intron-3CDSENST00000554585ENST00000556603AKT1chr14

105258935

-ITPK1chr14

93542964

-
intron-3CDSENST00000555458ENST00000267615AKT1chr14

105258935

-ITPK1chr14

93542964

-
intron-3CDSENST00000555458ENST00000354313AKT1chr14

105258935

-ITPK1chr14

93542964

-
intron-3CDSENST00000555458ENST00000556603AKT1chr14

105258935

-ITPK1chr14

93542964

-
intron-intronENST00000544168ENST00000555495AKT1chr14

105258935

-ITPK1chr14

93542964

-
intron-intronENST00000544168ENST00000556954AKT1chr14

105258935

-ITPK1chr14

93542964

-
intron-intronENST00000554192ENST00000555495AKT1chr14

105258935

-ITPK1chr14

93542964

-
intron-intronENST00000554192ENST00000556954AKT1chr14

105258935

-ITPK1chr14

93542964

-
intron-intronENST00000554585ENST00000555495AKT1chr14

105258935

-ITPK1chr14

93542964

-
intron-intronENST00000554585ENST00000556954AKT1chr14

105258935

-ITPK1chr14

93542964

-
intron-intronENST00000555458ENST00000555495AKT1chr14

105258935

-ITPK1chr14

93542964

-
intron-intronENST00000555458ENST00000556954AKT1chr14

105258935

-ITPK1chr14

93542964

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000402615AKT1chr14105258935-ENST00000267615ITPK1chr1493542964-7324152710872676529
ENST00000402615AKT1chr14105258935-ENST00000354313ITPK1chr1493542964-394615272064616482
ENST00000402615AKT1chr14105258935-ENST00000556603ITPK1chr1493542964-4485152710872676529
ENST00000555528AKT1chr14105258935-ENST00000267615ITPK1chr1493542964-64966992591848529
ENST00000555528AKT1chr14105258935-ENST00000354313ITPK1chr1493542964-31186992591548429
ENST00000555528AKT1chr14105258935-ENST00000556603ITPK1chr1493542964-36576992591848529

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000402615ENST00000267615AKT1chr14105258935-ITPK1chr1493542964-0.0040195310.9959805
ENST00000402615ENST00000354313AKT1chr14105258935-ITPK1chr1493542964-0.0037426480.9962573
ENST00000402615ENST00000556603AKT1chr14105258935-ITPK1chr1493542964-0.0055851090.9944149
ENST00000555528ENST00000267615AKT1chr14105258935-ITPK1chr1493542964-0.004198040.995802
ENST00000555528ENST00000354313AKT1chr14105258935-ITPK1chr1493542964-0.0052265010.99477357
ENST00000555528ENST00000556603AKT1chr14105258935-ITPK1chr1493542964-0.0072372640.99276274

Top

Fusion Genomic Features for AKT1-ITPK1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for AKT1-ITPK1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:105258935/chr14:93542964)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AKT1

P31749

ITPK1

Q13572

FUNCTION: AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis (PubMed:15526160, PubMed:11882383, PubMed:21620960, PubMed:21432781). This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates (PubMed:15526160, PubMed:11882383, PubMed:21620960, PubMed:21432781). Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported (PubMed:15526160, PubMed:11882383, PubMed:21620960, PubMed:21432781). AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface (By similarity). Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling (By similarity). Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport (PubMed:11994271). AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity (By similarity). Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven (By similarity). AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase) (PubMed:11154276). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis (PubMed:11154276). AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1 (PubMed:12150915). AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization (PubMed:10358075). In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319' (PubMed:10358075). FOXO3 and FOXO4 are phosphorylated on equivalent sites (PubMed:10358075). AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein) (PubMed:9829964). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1 (PubMed:9829964). AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis (By similarity). Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis (By similarity). Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity (By similarity). The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I) (PubMed:12176338, PubMed:12964941). AKT mediates the antiapoptotic effects of IGF-I (By similarity). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly (PubMed:19934221). May be involved in the regulation of the placental development (By similarity). Phosphorylates STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its: kinase activity, nuclear translocation, autophosphorylation and ability to phosphorylate FOXO3 (PubMed:17726016). Phosphorylates STK3/MST2 at 'Thr-117' and 'Thr-384' leading to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation (PubMed:20086174, PubMed:20231902). Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and ACIN1 and promotes its nuclear translocation (PubMed:19592491). Phosphorylates RAF1 at 'Ser-259' and negatively regulates its activity (PubMed:10576742). Phosphorylation of BAD stimulates its pro-apoptotic activity (PubMed:10926925). Phosphorylates KAT6A at 'Thr-369' and this phosphorylation inhibits the interaction of KAT6A with PML and negatively regulates its acetylation activity towards p53/TP53 (PubMed:23431171). Phosphorylates palladin (PALLD), modulating cytoskeletal organization and cell motility (PubMed:20471940). Phosphorylates prohibitin (PHB), playing an important role in cell metabolism and proliferation (PubMed:18507042). Phosphorylates CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization (PubMed:16982699). These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation (PubMed:16139227). Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation (PubMed:20682768). Phosphorylates PCK1 at 'Ser-90', reducing the binding affinity of PCK1 to oxaloacetate and changing PCK1 into an atypical protein kinase activity using GTP as donor (PubMed:32322062). {ECO:0000250|UniProtKB:P31750, ECO:0000250|UniProtKB:P47196, ECO:0000269|PubMed:10358075, ECO:0000269|PubMed:10576742, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11154276, ECO:0000269|PubMed:11994271, ECO:0000269|PubMed:12150915, ECO:0000269|PubMed:12176338, ECO:0000269|PubMed:12964941, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:16982699, ECO:0000269|PubMed:17726016, ECO:0000269|PubMed:18507042, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:19934221, ECO:0000269|PubMed:20086174, ECO:0000269|PubMed:20231902, ECO:0000269|PubMed:20471940, ECO:0000269|PubMed:20682768, ECO:0000269|PubMed:23431171, ECO:0000269|PubMed:32322062, ECO:0000269|PubMed:9829964, ECO:0000303|PubMed:11882383, ECO:0000303|PubMed:15526160, ECO:0000303|PubMed:21432781, ECO:0000303|PubMed:21620960}.FUNCTION: Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain (PubMed:11909533, PubMed:12925536, PubMed:17616525). Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:17616525). {ECO:0000269|PubMed:11909533, ECO:0000269|PubMed:12925536, ECO:0000269|PubMed:17616525}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneITPK1chr14:105258935chr14:93542964ENST00000267615111117_32531415.0DomainATP-grasp
TgeneITPK1chr14:105258935chr14:93542964ENST00000354313111117_32531315.0DomainATP-grasp
TgeneITPK1chr14:105258935chr14:93542964ENST00000556603111117_32531415.0DomainATP-grasp
TgeneITPK1chr14:105258935chr14:93542964ENST00000267615111188_19931415.0Nucleotide bindingNote=ATP
TgeneITPK1chr14:105258935chr14:93542964ENST00000354313111188_19931315.0Nucleotide bindingNote=ATP
TgeneITPK1chr14:105258935chr14:93542964ENST00000556603111188_19931415.0Nucleotide bindingNote=ATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAKT1chr14:105258935chr14:93542964ENST00000349310-315150_40815481.0DomainProtein kinase
HgeneAKT1chr14:105258935chr14:93542964ENST00000349310-315409_48015481.0DomainAGC-kinase C-terminal
HgeneAKT1chr14:105258935chr14:93542964ENST00000349310-3155_10815481.0DomainPH
HgeneAKT1chr14:105258935chr14:93542964ENST00000402615-214150_40815481.0DomainProtein kinase
HgeneAKT1chr14:105258935chr14:93542964ENST00000402615-214409_48015481.0DomainAGC-kinase C-terminal
HgeneAKT1chr14:105258935chr14:93542964ENST00000402615-2145_10815481.0DomainPH
HgeneAKT1chr14:105258935chr14:93542964ENST00000407796-214150_40815481.0DomainProtein kinase
HgeneAKT1chr14:105258935chr14:93542964ENST00000407796-214409_48015481.0DomainAGC-kinase C-terminal
HgeneAKT1chr14:105258935chr14:93542964ENST00000407796-2145_10815481.0DomainPH
HgeneAKT1chr14:105258935chr14:93542964ENST00000554581-113150_40815481.0DomainProtein kinase
HgeneAKT1chr14:105258935chr14:93542964ENST00000554581-113409_48015481.0DomainAGC-kinase C-terminal
HgeneAKT1chr14:105258935chr14:93542964ENST00000554581-1135_10815481.0DomainPH
HgeneAKT1chr14:105258935chr14:93542964ENST00000554848-214150_40815481.0DomainProtein kinase
HgeneAKT1chr14:105258935chr14:93542964ENST00000554848-214409_48015481.0DomainAGC-kinase C-terminal
HgeneAKT1chr14:105258935chr14:93542964ENST00000554848-2145_10815481.0DomainPH
HgeneAKT1chr14:105258935chr14:93542964ENST00000555528-214150_40815481.0DomainProtein kinase
HgeneAKT1chr14:105258935chr14:93542964ENST00000555528-214409_48015481.0DomainAGC-kinase C-terminal
HgeneAKT1chr14:105258935chr14:93542964ENST00000555528-2145_10815481.0DomainPH
HgeneAKT1chr14:105258935chr14:93542964ENST00000349310-315156_16415481.0Nucleotide bindingATP
HgeneAKT1chr14:105258935chr14:93542964ENST00000402615-214156_16415481.0Nucleotide bindingATP
HgeneAKT1chr14:105258935chr14:93542964ENST00000407796-214156_16415481.0Nucleotide bindingATP
HgeneAKT1chr14:105258935chr14:93542964ENST00000554581-113156_16415481.0Nucleotide bindingATP
HgeneAKT1chr14:105258935chr14:93542964ENST00000554848-214156_16415481.0Nucleotide bindingATP
HgeneAKT1chr14:105258935chr14:93542964ENST00000555528-214156_16415481.0Nucleotide bindingATP
HgeneAKT1chr14:105258935chr14:93542964ENST00000349310-31514_1915481.0RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
HgeneAKT1chr14:105258935chr14:93542964ENST00000349310-315228_23015481.0RegionNote=Inhibitor binding
HgeneAKT1chr14:105258935chr14:93542964ENST00000349310-31523_2515481.0RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
HgeneAKT1chr14:105258935chr14:93542964ENST00000402615-21414_1915481.0RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
HgeneAKT1chr14:105258935chr14:93542964ENST00000402615-214228_23015481.0RegionNote=Inhibitor binding
HgeneAKT1chr14:105258935chr14:93542964ENST00000402615-21423_2515481.0RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
HgeneAKT1chr14:105258935chr14:93542964ENST00000407796-21414_1915481.0RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
HgeneAKT1chr14:105258935chr14:93542964ENST00000407796-214228_23015481.0RegionNote=Inhibitor binding
HgeneAKT1chr14:105258935chr14:93542964ENST00000407796-21423_2515481.0RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
HgeneAKT1chr14:105258935chr14:93542964ENST00000554581-11314_1915481.0RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
HgeneAKT1chr14:105258935chr14:93542964ENST00000554581-113228_23015481.0RegionNote=Inhibitor binding
HgeneAKT1chr14:105258935chr14:93542964ENST00000554581-11323_2515481.0RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
HgeneAKT1chr14:105258935chr14:93542964ENST00000554848-21414_1915481.0RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
HgeneAKT1chr14:105258935chr14:93542964ENST00000554848-214228_23015481.0RegionNote=Inhibitor binding
HgeneAKT1chr14:105258935chr14:93542964ENST00000554848-21423_2515481.0RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
HgeneAKT1chr14:105258935chr14:93542964ENST00000555528-21414_1915481.0RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding
HgeneAKT1chr14:105258935chr14:93542964ENST00000555528-214228_23015481.0RegionNote=Inhibitor binding
HgeneAKT1chr14:105258935chr14:93542964ENST00000555528-21423_2515481.0RegionNote=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding


Top

Fusion Gene Sequence for AKT1-ITPK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3466_3466_1_AKT1-ITPK1_AKT1_chr14_105258935_ENST00000402615_ITPK1_chr14_93542964_ENST00000267615_length(transcript)=7324nt_BP=1527nt
AAGAATATGTGCTTATGGTAAAGGCAGGCGGCAGGTACGGAGGCTGTGGGAAGTCGGGGTCCCTCCGCCCCCACAGGCAGCCCTGTGCTG
GCCTGGTGTATACGTTTCTGTGCAGACGTACACCACCCTGTGTGAGCACAGATGTATTTTTACACATGGCTCTGGACAGCTGTCTGACTC
TGTCAGCAGCAGGCCTTGGAGGGGCTCAGGCCCGTGTGGGGGTGGGGGGACATCCAGAGGTCTTTGAGTCCAGCCCTCTGCCTCCAGGCC
ACGCCCACTCAGTGTCGTCAGAGCCCCCTGTGCCTGAGGCGTGCGCGGCTCGGAGCCCTGCCCTCGGAGTCCTGCGGTGCCTTCCTCGAG
TCTGGCCTGCTTTCCATCCTGCTAAGTACTTGGGGCATTTCCCTCTTTGGGTAAGGTGTGGTCTTCCCTGTCCTGGCATTAGACACAAGG
CAGTGGGCCTTCCTGCCATTCTAAGTGTAGCTTAAGACAATCAGTGCAAAGCAACCCTTTGTGGGTGTCCAGCCCTTGCCTCGGGAGGCC
AGAAAGGTGGCCTGGGGGGAGAGCGTCTAAGCTGGCTGTGGAAAGACCCATGTTGGGATCCATTCCACAGAGGTCGTCAGGGGTCTCTGC
CTGGCCTGGAGGTCCCAGAGAGGACCCTCCTCCCCTCAGGAAGGCCCATCTGGAAGGGTAGCAGAGGACTGCTCACAGGAAGAGCATGCG
AAGTGCTCTTTCTGGGGATGCCTGTAGTTGGTGATGTGGGAACTGGGTTTTGAGGGATGCCTAGGAGTTCATCCATCAGAGGGGAAATGA
GGAAGCCATGCAGGATCAATGGATAAAGTGTGCTCAGGTGAGGGTTGGCTGGTGGGCCGCTGCAGGGCGGGGGCCTGTCCAGTGCTCCCC
CACTTACTTGCTGCCTCCCGACTGCTGTAATTATGGGTCTGTAACCACCCTGGACTGGGTGCTCCTCACTGACGGACTTGTCTGAACCTC
TCTTTGTCTCCAGCGCCCAGCACTGGGCCTGGCAAAACCTGAGACGCCCGGTACATGTTGGCCAAATGAATGAACCAGATTCAGACCGGC
AGGGGCGCTGTGGTTTAGGAGGGGCCTGGGGTTTCTCCCAGGAGGTTTTTGGGCTTGCGCTGGAGGGCTCTGGACTCCCGTTTGCGCCAG
TGGCCTGCATCCTGGTCCTGTCTTCCTCATGTTTGAATTTCTTTGCTTTCCTAGTCTGGGGAGCAGGGAGGAGCCCTGTGCCCTGTCCCA
GGATCCATGGGTAGGAACACCATGGACAGGGAGAGCAAACGGGGCCATCTGTCACCAGGGGCTTAGGGAAGGCCGAGCCAGCCTGGGTCA
AAGAAGTCAAAGGGGCTGCCTGGAGGAGGCAGCCTGTCAGCTGGTGCATCAGAGGCTGTGGCCAGGCCAGCTGGGCTCGGGGAGCGCCAG
CCTGAGAGGAGCGCGTGAGCGTCGCGGGAGCCTCGGGCACCATGAGCGACGTGGCTATTGTGAAGGAGGGTTGGCTGCACAAACGAGGAA
GCGAGGGATGGAGGTTGTGCAGCTGAACCTTAGCCGGCCGATCGAGGAGCAGGGCCCCCTGGACGTCATCATCCACAAGCTGACTGACGT
CATCCTTGAAGCCGACCAGAATGATAGCCAGTCCCTGGAGCTGGTGCACAGGTTCCAGGAGTACATCGATGCCCACCCTGAGACCATCGT
CCTGGACCCGCTCCCTGCCATCAGAACCCTGCTTGACCGCTCCAAGTCCTATGAGCTCATCCGGAAGATTGAGGCCTACATGGAAGACGA
CAGGATCTGCTCGCCACCCTTCATGGAGCTCACGAGCCTGTGCGGGGATGACACCATGCGGCTGCTGGAGAAGAACGGCTTGACTTTCCC
ATTCATTTGCAAAACCAGAGTGGCTCATGGCACCAACTCTCACGAGATGGCTATCGTGTTCAACCAGGAGGGCCTGAACGCCATCCAGCC
ACCCTGCGTGGTCCAGAATTTCATCAACCACAACGCCGTCCTGTACAAGGTGTTCGTGGTTGGCGAGTCCTACACCGTGGTCCAGAGGCC
CTCACTCAAGAACTTCTCCGCAGGCACATCAGACCGTGAGTCCATCTTCTTCAACAGCCACAACGTGTCAAAGCCGGAGTCGTCATCGGT
CCTGACGGAGCTGGACAAGATCGAGGGCGTGTTCGAGCGGCCGAGCGACGAGGTCATCCGGGAGCTCTCCCGGGCCCTGCGGCAGGCACT
GGGCGTGTCACTCTTCGGCATCGACATCATCATCAACAACCAGACAGGGCAGCACGCCGTCATTGACATCAATGCCTTCCCAGGCTACGA
GGGCGTGAGCGAGTTCTTCACAGACCTCCTGAACCACATCGCCACTGTCCTGCAGGGCCAGAGCACAGCCATGGCAGCCACAGGGGACGT
GGCCCTGCTGAGGCACAGCAAGCTTCTGGCCGAGCCGGCGGGCGGCCTGGTGGGCGAGCGGACATGCAGCGCCAGCCCCGGCTGCTGCGG
CAGCATGATGGGCCAGGACGCGCCCTGGAAGGCTGAGGCCGACGCGGGCGGCACCGCCAAGCTGCCGCACCAGAGACTCGGCTGCAACGC
CGGCGTGTCGCCCAGCTTCCAGCAGCATTGTGTGGCCTCCCTGGCCACCAAGGCCTCCTCCCAGTAGCCACGGAGCCGGGACCCAGAGGG
GCAGCGCAGGGCGCAGAGCACACCCGCTGGGCCAGCAGCTCCCAACGGCGATGCTACTACTAAGAATCCCCAGTGATCTGATTCTTCTGT
TTTTTAATTTTTAACCTGATTCTCTGATGTCATGATCTAAATGAGGGGTAGTGGGGGATGGAAGAGAGTACCAGGTGGTCCACCGTTGGG
GAGTGGGGCCGTCCGCCTGCTCTCTACTGTGCAGACCTCCTAACTGAGTTTACACACGCTTGTGTTTGCAACACTAGGTCTGGATGGGAG
GTGAGGGGTGTGCGTATGGCTGCCATGCCAGTGTCTGTGCACATCCCTGTCTGTTGGTCTCCATGGCCACTGTGGACCGGGACCCTTGGG
GGAAGCCTGCCCATGTCGGGCTGTGGGAGGCTGATCGGTGCATGTGAGAGTGGCTTCCCTTCTGCCTGACTCCCCACTCCCTGACCTGCC
CCTTCCTTGTTTTTCCTCCTACTGGTCTCCACCAAGGCTTTGTTAGCCCCCACCCTGCCTGGTGTGCAGCTAACCCCTCCCTCCCCACAG
CCAGAGGAGGCCACAGACCCCTCAGGGGAGTTCCGCGCTGGGGTCTGGGCTGTGCTCCCTCACTAAAGGGAAGGAAAGGAAGCTGGGCGT
CCTCTGGGCCCCCCAACACACGTCCCATTTAGCCCTGCACAGCGGTCTCCTTCCCCTAAGCCAGCACTGCTGCTCCCTGGAGCCCGGGAA
GGAGGCTGCCTGGCTGGAGGCCCGAGCCGATGGCGCCTGTGCTGAGGATTTGTGCTGTGATTTGGGCAAATCATTCCAGGTCTTTGGGCC
TCCACCCCCTTGTCTCTAGTGGACATTTGAGATCAGAGAGCACCACAGGGCTGGCTTTGTGCCCTAACCCCTGGGATGCAGCCTGCCTTT
CCATAAAGTCACCTAGGTGAGGATAGGCGCGGGAGCCTCGGCATGACACCATGGAGATCGGGGCCCTCTTCCCAGTGGGTTCACTCCTTT
TCACACCTGCTGGGTCCCTCCTCACCCAGCAGGCCTGGTCCACCTCTCATTGCAAGCCCCAAGCACTGAGCCAGCAGGTGCCAGGGAGCC
ACCCGCCCCCCATCGCTTCTGCACACCTCAGACTCACCCCATCACCTTGGCAGCAAAGCACTGGCTCTGCCGTCTGACCCCTGATCCAGG
CAGCCCCCTCTGCAGAGAAAAGGGTTGGGGAGAAGCCTCTGCAGTCCTGGAAGATGTGGGGTGCTGGGTGAGAGGCATCAGCCCCCACAA
GTATGTTTTTGTGTCTTAAGATAGCAGTTTACTTTGAAAAAGTGAAAAAGGCTTCCGGGCTGTCCTCTGCCCAGTGAGATGGAGGACGCT
AGAGAAAGTGCTGAGTGTCCCGAGAGAGGCCCCCGAGCCAGTGCATGGAGGTCCTTCGGCCTGGCTCAGCTGGGCTGCAGGATGCCCACT
TTGAGGAGGGAGGCACAGGGCTTGGGCGAGGGGCAGAGGCCATCAGAACTGCCCGGCTTTTTTGGAAACTGAGGACCCAACAACTAACCA
CGTTTACACGACTTGAGTTTTGAACCCCGATTAATGTCTGTACGTCACCTTTCCTAGTTCTGACCCTGAGCCCTGGGGAACAGGAAAGCG
TGGCTGGCCTCTTGCACTGCTTTGTCTCCAAAATAAACTACTGAAATCAAACCGCATTTCACACGTGTTTACACATGTTGCTCAAGTTTG
TTATGTCATACTCCCAGTCCTTAAAAGACGTTTAATAAAACAGCTTTACCTTTTAAAAATAAAATTTCAATCCCAGTCTGCCTCAGGTAC
GGGTGGGGGTGTGCAGCGTGACTCCTGGCTGTGTTCCTGTACCGTTTGTGGCCTCCGGGGTCTTGCGCGTCCAGGGCCCAGATACCGAGT
AACTGCCATGTGGTGTCGTGGTGGCGTCCATAGGCCTCCGTGGTGGGGCGGGGGCGGGGCTGTGGGTGTGCAGGGCAGCTGCATTTTCCA
AGAGTGGAGATGGAGGATGGAGATTTGCTTCGTAAAGGCCTGGGAGCTACATGGGAGGTAGGGAGGGGCCAGCCACACCCAGGGCTGGGG
GGCCGGTGGACTCTGCCCAGTGAAGCCAGGGGAGTGTCAGCAATGAGGGGCCTGGACAGCGACGCGGGACCCGCACCTGGGAGCGGCAGA
GATGGAGCCCAGCTCGCTAAACGTACCCTAAGGGTGCACGCTGACCATCTTTGATCCCTGGACAGTGTCCATAGAGTTGTCTCCCCTTCG
GTCACATTGTCCCTGGCCTTGGAGTTTCTGCCTCAGGGAAAGACCCACTAAAACCACCCGGGCTCTGGCGGCCTCCTCTTCTCCAGAGCA
TGGTGGCGCTGCCTCCTGAGCAGAGTCACTGAGAGTGTCTGGGTCCAAGGAAGGGACCCACTTAGCAAAGGTTGTTGTGTGGTGCTGTGC
AGGCACGGCGCCTGGAGTTGGCCCCGCCAGCATCGGGGTGGCTTGGGGCTCTGGTTCCTAAGCTTCTGCTTCTGAGTTGGTCAGCACGTT
GGCTCTGCGCCCTGCAGTGCCTGTCTTGATGGTGGTCCCTGGATGTGCTGAAGGGCTCCAGGAGCAAGGGGCCAGACCACACTTTGGCTG
AGTCCTTGGGTAGTTTCAGAGGGTCACCTGCACAGTCTGCATTGAGCACCCTGGGGCTGAGGCCGTGGGTCAAGTTCTGCCTGACAGTGC
TTTGATTATATGGTGATGTGATTCTGCAAACATAACCCCCCAACTGAGTGCCAGCTGCTGGGTGTCCCCACCCCAAGAGCCAAGGGGAGG
CCACCCTGGAACTGGTGCTTTGCCCTTGGTGTCATGGAGGTGTCTGGGTCCACACGTGGTGGGTGGGCTGGGCCTGCAGTCACCCAGCAT
GGCCGGCGGGATTGGACCCAGCTGCAACCTGGCAGGTTCCATGGGGCTTCCTGTGCCTGGGCCTGCCTGTGTCTCATGCCTGTCAATAAA
GGAGAAAGCAACCTGGGAAAAACATTCCTCTCTGTACCCAGGGGACTGCCAAGTGTGCTTTATAGAAGGCTGGAAGACCGACTGAAGTAG
GAAGCTGTCACATGTTTGAGCCAACTGAGCAAAGCAGCTGTTGCCTGCCAGACAGCCACCCCAAGACCAAGGGAGCCAGCCTGTCGTTTG
TCCTTCTAGCCTGGAAGACCAGTTCTTGGCTCTTGGGCACTCACATTGGCCACTGGCCACAACTGCTGAATGGCTTCACTAATGTCCCTG
GGGTCTGTATCTGCCCTCTCTTCTATTCCCTAGAAACTCTGGCCGGGCATGGCGGCTCACGCCTGTCATCCCAGCACTTAGGGAGGCTGA
GGCAGGTGGATCACAAGGTCAAGAGATCGACACCATCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGA
CATGGTGGTGGGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACTCGGGAGGCGTAGGTTGCAGTGAGCCA
AGATCGCACCACTGCACTCCAGCCTGGCAACAGAGCAAGACTCCTCAAAAAACAAACAAACAAACAAACAAACTCTGATCATTCACCCGG
TGGGATCCCCGGCAGCTCCTTCTCCTTCCCGAGCTGTGGCTCATGGGCCATTGGATTCAGAGACCTTGAGCTGGGTGCTGGCTGCCCTAA
AGGAGCACGACCCCTCCAGCCTGGTGACCGGGAGGCAGAGAAGTGCAGCTGTCCTTGACAAAGGCCCAGCCTCTGCTGCCTCAGGCCAGC
CTGGCCACACCCCGATGCCACAGTCATCTGCCCCGCCCAGGCATAAGCCTGACTCAGGTGATACAGGCGAGGCTTCTCCCATGGGTCCTC
CCCTTGTGAGAAAGGGTCTGTGCTGTGTACCTTCTCTCTGCACAGCCATTGTCAGTGTGGTTTGGAGTGAGTGAGCCTCCCGCACTGCTC
AGGGGAGAGCTGGTGAGCATGACTCCATGGCCTCCTGCTGGTTGGGGTCTTCTTCTGATTCTCACCCGCAGGAGCACCCAGACCCCCCCT
TTTCAGAAATGATTACATTTTCCCTTCAAGAGTCATCTGTGACCTGGTGGTGTGGAGGGACTGTCCCCTCCTGCAGCCTGGCCGACCCCC
TTCCTCCAGGGCTGTGTGGAATCACCTCTCAGAAGCTCACTCTGAAAAGCCACTCACAGGGATTTCACCAGGATGTTGCTGTTCCTGCCG
ACACCTGGGCTTTGTGACAAATGCTGTTTGCTTCAAGCTGTTCACAAGCAACTTCACCAGAATCCCAAGCTGGTTCGTACTTAATTTGTG
TACATACATATGCATAATATACATGACCATGTATGAGATACAGACACCATGGCTTCTGTCCATTGGCTCATTCGCCTGGTCGCATGTTCA
CTCCATGAGGTTAGGACACTGCGGGTGGCTTTGGGATGGGTGGTTTCAGGGACAAGGTGTCGCTATGATCTCTGTATTTGCTAACTAGTC
TTGTTTTGATTTCTAACGGTCTAGTGGAGTACAGTTAATGTTGTGTTTATTTCTGTAACTGTAGGGGTGGAGTATAAACCTAACTTTTGG

>3466_3466_1_AKT1-ITPK1_AKT1_chr14_105258935_ENST00000402615_ITPK1_chr14_93542964_ENST00000267615_length(amino acids)=529AA_BP=146
MWFRRGLGFLPGGFWACAGGLWTPVCASGLHPGPVFLMFEFLCFPSLGSREEPCALSQDPWVGTPWTGRANGAICHQGLREGRASLGQRS
QRGCLEEAACQLVHQRLWPGQLGSGSASLRGARERRGSLGHHERRGYCEGGLAAQTRKRGMEVVQLNLSRPIEEQGPLDVIIHKLTDVIL
EADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSYELIRKIEAYMEDDRICSPPFMELTSLCGDDTMRLLEKNGLTFPFI
CKTRVAHGTNSHEMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLT
ELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIATVLQGQSTAMAATGDVAL

--------------------------------------------------------------
>3466_3466_2_AKT1-ITPK1_AKT1_chr14_105258935_ENST00000402615_ITPK1_chr14_93542964_ENST00000354313_length(transcript)=3946nt_BP=1527nt
AAGAATATGTGCTTATGGTAAAGGCAGGCGGCAGGTACGGAGGCTGTGGGAAGTCGGGGTCCCTCCGCCCCCACAGGCAGCCCTGTGCTG
GCCTGGTGTATACGTTTCTGTGCAGACGTACACCACCCTGTGTGAGCACAGATGTATTTTTACACATGGCTCTGGACAGCTGTCTGACTC
TGTCAGCAGCAGGCCTTGGAGGGGCTCAGGCCCGTGTGGGGGTGGGGGGACATCCAGAGGTCTTTGAGTCCAGCCCTCTGCCTCCAGGCC
ACGCCCACTCAGTGTCGTCAGAGCCCCCTGTGCCTGAGGCGTGCGCGGCTCGGAGCCCTGCCCTCGGAGTCCTGCGGTGCCTTCCTCGAG
TCTGGCCTGCTTTCCATCCTGCTAAGTACTTGGGGCATTTCCCTCTTTGGGTAAGGTGTGGTCTTCCCTGTCCTGGCATTAGACACAAGG
CAGTGGGCCTTCCTGCCATTCTAAGTGTAGCTTAAGACAATCAGTGCAAAGCAACCCTTTGTGGGTGTCCAGCCCTTGCCTCGGGAGGCC
AGAAAGGTGGCCTGGGGGGAGAGCGTCTAAGCTGGCTGTGGAAAGACCCATGTTGGGATCCATTCCACAGAGGTCGTCAGGGGTCTCTGC
CTGGCCTGGAGGTCCCAGAGAGGACCCTCCTCCCCTCAGGAAGGCCCATCTGGAAGGGTAGCAGAGGACTGCTCACAGGAAGAGCATGCG
AAGTGCTCTTTCTGGGGATGCCTGTAGTTGGTGATGTGGGAACTGGGTTTTGAGGGATGCCTAGGAGTTCATCCATCAGAGGGGAAATGA
GGAAGCCATGCAGGATCAATGGATAAAGTGTGCTCAGGTGAGGGTTGGCTGGTGGGCCGCTGCAGGGCGGGGGCCTGTCCAGTGCTCCCC
CACTTACTTGCTGCCTCCCGACTGCTGTAATTATGGGTCTGTAACCACCCTGGACTGGGTGCTCCTCACTGACGGACTTGTCTGAACCTC
TCTTTGTCTCCAGCGCCCAGCACTGGGCCTGGCAAAACCTGAGACGCCCGGTACATGTTGGCCAAATGAATGAACCAGATTCAGACCGGC
AGGGGCGCTGTGGTTTAGGAGGGGCCTGGGGTTTCTCCCAGGAGGTTTTTGGGCTTGCGCTGGAGGGCTCTGGACTCCCGTTTGCGCCAG
TGGCCTGCATCCTGGTCCTGTCTTCCTCATGTTTGAATTTCTTTGCTTTCCTAGTCTGGGGAGCAGGGAGGAGCCCTGTGCCCTGTCCCA
GGATCCATGGGTAGGAACACCATGGACAGGGAGAGCAAACGGGGCCATCTGTCACCAGGGGCTTAGGGAAGGCCGAGCCAGCCTGGGTCA
AAGAAGTCAAAGGGGCTGCCTGGAGGAGGCAGCCTGTCAGCTGGTGCATCAGAGGCTGTGGCCAGGCCAGCTGGGCTCGGGGAGCGCCAG
CCTGAGAGGAGCGCGTGAGCGTCGCGGGAGCCTCGGGCACCATGAGCGACGTGGCTATTGTGAAGGAGGGTTGGCTGCACAAACGAGGAA
GCGAGGGATGGAGGTTGTGCAGCTGAACCTTAGCCGGCCGATCGAGGAGCAGGGCCCCCTGGACGTCATCATCCACAAGCTGACTGACGT
CATCCTTGAAGCCGACCAGAATGATAGCCAGTCCCTGGAGCTGGTGCACAGGTTCCAGGAGTACATCGATGCCCACCCTGAGACCATCGT
CCTGGACCCGCTCCCTGCCATCAGAACCCTGCTTGACCGCTCCAAGTCCTATGAGCTCATCCGGAAGATTGAGGCCTACATGGAAGACGA
CAGGATCTGCTCGCCACCCTTCATGGAGCTCACGAGCCTGTGCGGGGATGACACCATGCGGCTGCTGGAGAAGAACGGCTTGACTTTCCC
ATTCATTTGCAAAACCAGAGTGGCTCATGGCACCAACTCTCACGAGATGGCTATCGTGTTCAACCAGGAGGGCCTGAACGCCATCCAGCC
ACCCTGCGTGGTCCAGAATTTCATCAACCACAACGCCGTCCTGTACAAGGTGTTCGTGGTTGGCGAGTCCTACACCGTGGTCCAGAGGCC
CTCACTCAAGAACTTCTCCGCAGGCACATCAGACCGTGAGTCCATCTTCTTCAACAGCCACAACGTGTCAAAGCCGGAGTCGTCATCGGT
CCTGACGGAGCTGGACAAGATCGAGGGCGTGTTCGAGCGGCCGAGCGACGAGGTCATCCGGGAGCTCTCCCGGGCCCTGCGGCAGGCACT
GGGCGTGTCACTCTTCGGCATCGACATCATCATCAACAACCAGACAGGGCAGCACGCCGTCATTGACATCAATGCCTTCCCAGGGGACTG
CCAAGTGTGCTTTATAGAAGGCTGGAAGACCGACTGAAGTAGGAAGCTGTCACATGTTTGAGCCAACTGAGCAAAGCAGCTGTTGCCTGC
CAGACAGCCACCCCAAGACCAAGGGAGCCAGCCTGTCGTTTGTCCTTCTAGCCTGGAAGACCAGTTCTTGGCTCTTGGGCACTCACATTG
GCCACTGGCCACAACTGCTGAATGGCTTCACTAATGTCCCTGGGGTCTGTATCTGCCCTCTCTTCTATTCCCTAGAAACTCTGGCCGGGC
ATGGCGGCTCACGCCTGTCATCCCAGCACTTAGGGAGGCTGAGGCAGGTGGATCACAAGGTCAAGAGATCGACACCATCCTGGCCAACAT
GGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGACATGGTGGTGGGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAG
GAGAATTGCTTGAACTCGGGAGGCGTAGGTTGCAGTGAGCCAAGATCGCACCACTGCACTCCAGCCTGGCAACAGAGCAAGACTCCTCAA
AAAACAAACAAACAAACAAACAAACTCTGATCATTCACCCGGTGGGATCCCCGGCAGCTCCTTCTCCTTCCCGAGCTGTGGCTCATGGGC
CATTGGATTCAGAGACCTTGAGCTGGGTGCTGGCTGCCCTAAAGGAGCACGACCCCTCCAGCCTGGTGACCGGGAGGCAGAGAAGTGCAG
CTGTCCTTGACAAAGGCCCAGCCTCTGCTGCCTCAGGCCAGCCTGGCCACACCCCGATGCCACAGTCATCTGCCCCGCCCAGGCATAAGC
CTGACTCAGGTGATACAGGCGAGGCTTCTCCCATGGGTCCTCCCCTTGTGAGAAAGGGTCTGTGCTGTGTACCTTCTCTCTGCACAGCCA
TTGTCAGTGTGGTTTGGAGTGAGTGAGCCTCCCGCACTGCTCAGGGGAGAGCTGGTGAGCATGACTCCATGGCCTCCTGCTGGTTGGGGT
CTTCTTCTGATTCTCACCCGCAGGAGCACCCAGACCCCCCCTTTTCAGAAATGATTACATTTTCCCTTCAAGAGTCATCTGTGACCTGGT
GGTGTGGAGGGACTGTCCCCTCCTGCAGCCTGGCCGACCCCCTTCCTCCAGGGCTGTGTGGAATCACCTCTCAGAAGCTCACTCTGAAAA
GCCACTCACAGGGATTTCACCAGGATGTTGCTGTTCCTGCCGACACCTGGGCTTTGTGACAAATGCTGTTTGCTTCAAGCTGTTCACAAG
CAACTTCACCAGAATCCCAAGCTGGTTCGTACTTAATTTGTGTACATACATATGCATAATATACATGACCATGTATGAGATACAGACACC
ATGGCTTCTGTCCATTGGCTCATTCGCCTGGTCGCATGTTCACTCCATGAGGTTAGGACACTGCGGGTGGCTTTGGGATGGGTGGTTTCA
GGGACAAGGTGTCGCTATGATCTCTGTATTTGCTAACTAGTCTTGTTTTGATTTCTAACGGTCTAGTGGAGTACAGTTAATGTTGTGTTT

>3466_3466_2_AKT1-ITPK1_AKT1_chr14_105258935_ENST00000402615_ITPK1_chr14_93542964_ENST00000354313_length(amino acids)=482AA_BP=1
MDHGVGLANHEHLVQDGVVVDEILDHAGWLDGVQALLVEHDSHLVRVGAMSHSGFANEWESQAVLLQQPHGVIPAQARELHEGWRADPVV
FHVGLNLPDELIGLGAVKQGSDGRERVQDDGLRVGIDVLLEPVHQLQGLAIILVGFKDDVSQLVDDDVQGALLLDRPAKVQLHNLHPSLP
RLCSQPSFTIATSLMVPEAPATLTRSSQAGAPRAQLAWPQPLMHQLTGCLLQAAPLTSLTQAGSAFPKPLVTDGPVCSPCPWCSYPWILG
QGTGLLPAPQTRKAKKFKHEEDRTRMQATGANGSPEPSSASPKTSWEKPQAPPKPQRPCRSESGSFIWPTCTGRLRFCQAQCWALETKRG
SDKSVSEEHPVQGGYRPIITAVGRQQVSGGALDRPPPCSGPPANPHLSTLYPLILHGFLISPLMDELLGIPQNPVPTSPTTGIPRKSTSH

--------------------------------------------------------------
>3466_3466_3_AKT1-ITPK1_AKT1_chr14_105258935_ENST00000402615_ITPK1_chr14_93542964_ENST00000556603_length(transcript)=4485nt_BP=1527nt
AAGAATATGTGCTTATGGTAAAGGCAGGCGGCAGGTACGGAGGCTGTGGGAAGTCGGGGTCCCTCCGCCCCCACAGGCAGCCCTGTGCTG
GCCTGGTGTATACGTTTCTGTGCAGACGTACACCACCCTGTGTGAGCACAGATGTATTTTTACACATGGCTCTGGACAGCTGTCTGACTC
TGTCAGCAGCAGGCCTTGGAGGGGCTCAGGCCCGTGTGGGGGTGGGGGGACATCCAGAGGTCTTTGAGTCCAGCCCTCTGCCTCCAGGCC
ACGCCCACTCAGTGTCGTCAGAGCCCCCTGTGCCTGAGGCGTGCGCGGCTCGGAGCCCTGCCCTCGGAGTCCTGCGGTGCCTTCCTCGAG
TCTGGCCTGCTTTCCATCCTGCTAAGTACTTGGGGCATTTCCCTCTTTGGGTAAGGTGTGGTCTTCCCTGTCCTGGCATTAGACACAAGG
CAGTGGGCCTTCCTGCCATTCTAAGTGTAGCTTAAGACAATCAGTGCAAAGCAACCCTTTGTGGGTGTCCAGCCCTTGCCTCGGGAGGCC
AGAAAGGTGGCCTGGGGGGAGAGCGTCTAAGCTGGCTGTGGAAAGACCCATGTTGGGATCCATTCCACAGAGGTCGTCAGGGGTCTCTGC
CTGGCCTGGAGGTCCCAGAGAGGACCCTCCTCCCCTCAGGAAGGCCCATCTGGAAGGGTAGCAGAGGACTGCTCACAGGAAGAGCATGCG
AAGTGCTCTTTCTGGGGATGCCTGTAGTTGGTGATGTGGGAACTGGGTTTTGAGGGATGCCTAGGAGTTCATCCATCAGAGGGGAAATGA
GGAAGCCATGCAGGATCAATGGATAAAGTGTGCTCAGGTGAGGGTTGGCTGGTGGGCCGCTGCAGGGCGGGGGCCTGTCCAGTGCTCCCC
CACTTACTTGCTGCCTCCCGACTGCTGTAATTATGGGTCTGTAACCACCCTGGACTGGGTGCTCCTCACTGACGGACTTGTCTGAACCTC
TCTTTGTCTCCAGCGCCCAGCACTGGGCCTGGCAAAACCTGAGACGCCCGGTACATGTTGGCCAAATGAATGAACCAGATTCAGACCGGC
AGGGGCGCTGTGGTTTAGGAGGGGCCTGGGGTTTCTCCCAGGAGGTTTTTGGGCTTGCGCTGGAGGGCTCTGGACTCCCGTTTGCGCCAG
TGGCCTGCATCCTGGTCCTGTCTTCCTCATGTTTGAATTTCTTTGCTTTCCTAGTCTGGGGAGCAGGGAGGAGCCCTGTGCCCTGTCCCA
GGATCCATGGGTAGGAACACCATGGACAGGGAGAGCAAACGGGGCCATCTGTCACCAGGGGCTTAGGGAAGGCCGAGCCAGCCTGGGTCA
AAGAAGTCAAAGGGGCTGCCTGGAGGAGGCAGCCTGTCAGCTGGTGCATCAGAGGCTGTGGCCAGGCCAGCTGGGCTCGGGGAGCGCCAG
CCTGAGAGGAGCGCGTGAGCGTCGCGGGAGCCTCGGGCACCATGAGCGACGTGGCTATTGTGAAGGAGGGTTGGCTGCACAAACGAGGAA
GCGAGGGATGGAGGTTGTGCAGCTGAACCTTAGCCGGCCGATCGAGGAGCAGGGCCCCCTGGACGTCATCATCCACAAGCTGACTGACGT
CATCCTTGAAGCCGACCAGAATGATAGCCAGTCCCTGGAGCTGGTGCACAGGTTCCAGGAGTACATCGATGCCCACCCTGAGACCATCGT
CCTGGACCCGCTCCCTGCCATCAGAACCCTGCTTGACCGCTCCAAGTCCTATGAGCTCATCCGGAAGATTGAGGCCTACATGGAAGACGA
CAGGATCTGCTCGCCACCCTTCATGGAGCTCACGAGCCTGTGCGGGGATGACACCATGCGGCTGCTGGAGAAGAACGGCTTGACTTTCCC
ATTCATTTGCAAAACCAGAGTGGCTCATGGCACCAACTCTCACGAGATGGCTATCGTGTTCAACCAGGAGGGCCTGAACGCCATCCAGCC
ACCCTGCGTGGTCCAGAATTTCATCAACCACAACGCCGTCCTGTACAAGGTGTTCGTGGTTGGCGAGTCCTACACCGTGGTCCAGAGGCC
CTCACTCAAGAACTTCTCCGCAGGCACATCAGACCGTGAGTCCATCTTCTTCAACAGCCACAACGTGTCAAAGCCGGAGTCGTCATCGGT
CCTGACGGAGCTGGACAAGATCGAGGGCGTGTTCGAGCGGCCGAGCGACGAGGTCATCCGGGAGCTCTCCCGGGCCCTGCGGCAGGCACT
GGGCGTGTCACTCTTCGGCATCGACATCATCATCAACAACCAGACAGGGCAGCACGCCGTCATTGACATCAATGCCTTCCCAGGCTACGA
GGGCGTGAGCGAGTTCTTCACAGACCTCCTGAACCACATCGCCACTGTCCTGCAGGGCCAGAGCACAGCCATGGCAGCCACAGGGGACGT
GGCCCTGCTGAGGCACAGCAAGCTTCTGGCCGAGCCGGCGGGCGGCCTGGTGGGCGAGCGGACATGCAGCGCCAGCCCCGGCTGCTGCGG
CAGCATGATGGGCCAGGACGCGCCCTGGAAGGCTGAGGCCGACGCGGGCGGCACCGCCAAGCTGCCGCACCAGAGACTCGGCTGCAACGC
CGGCGTGTCGCCCAGCTTCCAGCAGCATTGTGTGGCCTCCCTGGCCACCAAGGCCTCCTCCCAGTAGCCACGGAGCCGGGACCCAGAGGG
GCAGCGCAGGGCGCAGAGCACACCCGCTGGGCCAGCAGCTCCCAACGGCGATGCTACTACTAAGAATCCCCAGTGATCTGATTCTTCTGT
TTTTTAATTTTTAACCTGATTCTCTGATGTCATGATCTAAATGAGGGGTAGTGGGGGATGGAAGAGAGTACCAGGTGGTCCACCGTTGGG
GAGTGGGGCCGTCCGCCTGCTCTCTACTGTGCAGACCTCCTAACTGAGTTTACACACGCTTGTGTTTGCAACACTAGGTCTGGATGGGAG
GTGAGGGGTGTGCGTATGGCTGCCATGCCAGTGTCTGTGCACATCCCTGTCTGTTGGTCTCCATGGCCACTGTGGACCGGGACCCTTGGG
GGAAGCCTGCCCATGTCGGGCTGTGGGAGGCTGATCGGTGCATGTGAGAGTGGCTTCCCTTCTGCCTGACTCCCCACTCCCTGACCTGCC
CCTTCCTTGTTTTTCCTCCTACTGGTCTCCACCAAGGCTTTGTTAGCCCCCACCCTGCCTGGTGTGCAGCTAACCCCTCCCTCCCCACAG
CCAGAGGAGGCCACAGACCCCTCAGGGGAGTTCCGCGCTGGGGTCTGGGCTGTGCTCCCTCACTAAAGGGAAGGAAAGGAAGCTGGGCGT
CCTCTGGGCCCCCCAACACACGTCCCATTTAGCCCTGCACAGCGGTCTCCTTCCCCTAAGCCAGCACTGCTGCTCCCTGGAGCCCGGGAA
GGAGGCTGCCTGGCTGGAGGCCCGAGCCGATGGCGCCTGTGCTGAGGATTTGTGCTGTGATTTGGGCAAATCATTCCAGGTCTTTGGGCC
TCCACCCCCTTGTCTCTAGTGGACATTTGAGATCAGAGAGCACCACAGGGCTGGCTTTGTGCCCTAACCCCTGGGATGCAGCCTGCCTTT
CCATAAAGTCACCTAGGTGAGGATAGGCGCGGGAGCCTCGGCATGACACCATGGAGATCGGGGCCCTCTTCCCAGTGGGTTCACTCCTTT
TCACACCTGCTGGGTCCCTCCTCACCCAGCAGGCCTGGTCCACCTCTCATTGCAAGCCCCAAGCACTGAGCCAGCAGGTGCCAGGGAGCC
ACCCGCCCCCCATCGCTTCTGCACACCTCAGACTCACCCCATCACCTTGGCAGCAAAGCACTGGCTCTGCCGTCTGACCCCTGATCCAGG
CAGCCCCCTCTGCAGAGAAAAGGGTTGGGGAGAAGCCTCTGCAGTCCTGGAAGATGTGGGGTGCTGGGTGAGAGGCATCAGCCCCCACAA
GTATGTTTTTGTGTCTTAAGATAGCAGTTTACTTTGAAAAAGTGAAAAAGGCTTCCGGGCTGTCCTCTGCCCAGTGAGATGGAGGACGCT
AGAGAAAGTGCTGAGTGTCCCGAGAGAGGCCCCCGAGCCAGTGCATGGAGGTCCTTCGGCCTGGCTCAGCTGGGCTGCAGGATGCCCACT
TTGAGGAGGGAGGCACAGGGCTTGGGCGAGGGGCAGAGGCCATCAGAACTGCCCGGCTTTTTTGGAAACTGAGGACCCAACAACTAACCA
CGTTTACACGACTTGAGTTTTGAACCCCGATTAATGTCTGTACGTCACCTTTCCTAGTTCTGACCCTGAGCCCTGGGGAACAGGAAAGCG
TGGCTGGCCTCTTGCACTGCTTTGTCTCCAAAATAAACTACTGAAATCAAACCGCATTTCACACGTGTTTACACATGTTGCTCAAGTTTG

>3466_3466_3_AKT1-ITPK1_AKT1_chr14_105258935_ENST00000402615_ITPK1_chr14_93542964_ENST00000556603_length(amino acids)=529AA_BP=146
MWFRRGLGFLPGGFWACAGGLWTPVCASGLHPGPVFLMFEFLCFPSLGSREEPCALSQDPWVGTPWTGRANGAICHQGLREGRASLGQRS
QRGCLEEAACQLVHQRLWPGQLGSGSASLRGARERRGSLGHHERRGYCEGGLAAQTRKRGMEVVQLNLSRPIEEQGPLDVIIHKLTDVIL
EADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSYELIRKIEAYMEDDRICSPPFMELTSLCGDDTMRLLEKNGLTFPFI
CKTRVAHGTNSHEMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLT
ELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIATVLQGQSTAMAATGDVAL

--------------------------------------------------------------
>3466_3466_4_AKT1-ITPK1_AKT1_chr14_105258935_ENST00000555528_ITPK1_chr14_93542964_ENST00000267615_length(transcript)=6496nt_BP=699nt
ATGGATAAAGTGTGCTCAGGTGAGGGTTGGCTGGTGGGCCGCTGCAGGGCGGGGGCCTGTCCAGTGCTCCCCCACTTACTTGCTGCCTCC
CGACTGCTGTAATTATGGGTCTGTAACCACCCTGGACTGGGTGCTCCTCACTGACGGACTTGTCTGAACCTCTCTTTGTCTCCAGCGCCC
AGCACTGGGCCTGGCAAAACCTGAGACGCCCGGTACATGTTGGCCAAATGAATGAACCAGATTCAGACCGGCAGGGGCGCTGTGGTTTAG
GAGGGGCCTGGGGTTTCTCCCAGGAGGTTTTTGGGCTTGCGCTGGAGGGCTCTGGACTCCCGTTTGCGCCAGTGGCCTGCATCCTGGTCC
TGTCTTCCTCATGTTTGAATTTCTTTGCTTTCCTAGTCTGGGGAGCAGGGAGGAGCCCTGTGCCCTGTCCCAGGATCCATGGGTAGGAAC
ACCATGGACAGGGAGAGCAAACGGGGCCATCTGTCACCAGGGGCTTAGGGAAGGCCGAGCCAGCCTGGGTCAAAGAAGTCAAAGGGGCTG
CCTGGAGGAGGCAGCCTGTCAGCTGGTGCATCAGAGGCTGTGGCCAGGCCAGCTGGGCTCGGGGAGCGCCAGCCTGAGAGGAGCGCGTGA
GCGTCGCGGGAGCCTCGGGCACCATGAGCGACGTGGCTATTGTGAAGGAGGGTTGGCTGCACAAACGAGGAAGCGAGGGATGGAGGTTGT
GCAGCTGAACCTTAGCCGGCCGATCGAGGAGCAGGGCCCCCTGGACGTCATCATCCACAAGCTGACTGACGTCATCCTTGAAGCCGACCA
GAATGATAGCCAGTCCCTGGAGCTGGTGCACAGGTTCCAGGAGTACATCGATGCCCACCCTGAGACCATCGTCCTGGACCCGCTCCCTGC
CATCAGAACCCTGCTTGACCGCTCCAAGTCCTATGAGCTCATCCGGAAGATTGAGGCCTACATGGAAGACGACAGGATCTGCTCGCCACC
CTTCATGGAGCTCACGAGCCTGTGCGGGGATGACACCATGCGGCTGCTGGAGAAGAACGGCTTGACTTTCCCATTCATTTGCAAAACCAG
AGTGGCTCATGGCACCAACTCTCACGAGATGGCTATCGTGTTCAACCAGGAGGGCCTGAACGCCATCCAGCCACCCTGCGTGGTCCAGAA
TTTCATCAACCACAACGCCGTCCTGTACAAGGTGTTCGTGGTTGGCGAGTCCTACACCGTGGTCCAGAGGCCCTCACTCAAGAACTTCTC
CGCAGGCACATCAGACCGTGAGTCCATCTTCTTCAACAGCCACAACGTGTCAAAGCCGGAGTCGTCATCGGTCCTGACGGAGCTGGACAA
GATCGAGGGCGTGTTCGAGCGGCCGAGCGACGAGGTCATCCGGGAGCTCTCCCGGGCCCTGCGGCAGGCACTGGGCGTGTCACTCTTCGG
CATCGACATCATCATCAACAACCAGACAGGGCAGCACGCCGTCATTGACATCAATGCCTTCCCAGGCTACGAGGGCGTGAGCGAGTTCTT
CACAGACCTCCTGAACCACATCGCCACTGTCCTGCAGGGCCAGAGCACAGCCATGGCAGCCACAGGGGACGTGGCCCTGCTGAGGCACAG
CAAGCTTCTGGCCGAGCCGGCGGGCGGCCTGGTGGGCGAGCGGACATGCAGCGCCAGCCCCGGCTGCTGCGGCAGCATGATGGGCCAGGA
CGCGCCCTGGAAGGCTGAGGCCGACGCGGGCGGCACCGCCAAGCTGCCGCACCAGAGACTCGGCTGCAACGCCGGCGTGTCGCCCAGCTT
CCAGCAGCATTGTGTGGCCTCCCTGGCCACCAAGGCCTCCTCCCAGTAGCCACGGAGCCGGGACCCAGAGGGGCAGCGCAGGGCGCAGAG
CACACCCGCTGGGCCAGCAGCTCCCAACGGCGATGCTACTACTAAGAATCCCCAGTGATCTGATTCTTCTGTTTTTTAATTTTTAACCTG
ATTCTCTGATGTCATGATCTAAATGAGGGGTAGTGGGGGATGGAAGAGAGTACCAGGTGGTCCACCGTTGGGGAGTGGGGCCGTCCGCCT
GCTCTCTACTGTGCAGACCTCCTAACTGAGTTTACACACGCTTGTGTTTGCAACACTAGGTCTGGATGGGAGGTGAGGGGTGTGCGTATG
GCTGCCATGCCAGTGTCTGTGCACATCCCTGTCTGTTGGTCTCCATGGCCACTGTGGACCGGGACCCTTGGGGGAAGCCTGCCCATGTCG
GGCTGTGGGAGGCTGATCGGTGCATGTGAGAGTGGCTTCCCTTCTGCCTGACTCCCCACTCCCTGACCTGCCCCTTCCTTGTTTTTCCTC
CTACTGGTCTCCACCAAGGCTTTGTTAGCCCCCACCCTGCCTGGTGTGCAGCTAACCCCTCCCTCCCCACAGCCAGAGGAGGCCACAGAC
CCCTCAGGGGAGTTCCGCGCTGGGGTCTGGGCTGTGCTCCCTCACTAAAGGGAAGGAAAGGAAGCTGGGCGTCCTCTGGGCCCCCCAACA
CACGTCCCATTTAGCCCTGCACAGCGGTCTCCTTCCCCTAAGCCAGCACTGCTGCTCCCTGGAGCCCGGGAAGGAGGCTGCCTGGCTGGA
GGCCCGAGCCGATGGCGCCTGTGCTGAGGATTTGTGCTGTGATTTGGGCAAATCATTCCAGGTCTTTGGGCCTCCACCCCCTTGTCTCTA
GTGGACATTTGAGATCAGAGAGCACCACAGGGCTGGCTTTGTGCCCTAACCCCTGGGATGCAGCCTGCCTTTCCATAAAGTCACCTAGGT
GAGGATAGGCGCGGGAGCCTCGGCATGACACCATGGAGATCGGGGCCCTCTTCCCAGTGGGTTCACTCCTTTTCACACCTGCTGGGTCCC
TCCTCACCCAGCAGGCCTGGTCCACCTCTCATTGCAAGCCCCAAGCACTGAGCCAGCAGGTGCCAGGGAGCCACCCGCCCCCCATCGCTT
CTGCACACCTCAGACTCACCCCATCACCTTGGCAGCAAAGCACTGGCTCTGCCGTCTGACCCCTGATCCAGGCAGCCCCCTCTGCAGAGA
AAAGGGTTGGGGAGAAGCCTCTGCAGTCCTGGAAGATGTGGGGTGCTGGGTGAGAGGCATCAGCCCCCACAAGTATGTTTTTGTGTCTTA
AGATAGCAGTTTACTTTGAAAAAGTGAAAAAGGCTTCCGGGCTGTCCTCTGCCCAGTGAGATGGAGGACGCTAGAGAAAGTGCTGAGTGT
CCCGAGAGAGGCCCCCGAGCCAGTGCATGGAGGTCCTTCGGCCTGGCTCAGCTGGGCTGCAGGATGCCCACTTTGAGGAGGGAGGCACAG
GGCTTGGGCGAGGGGCAGAGGCCATCAGAACTGCCCGGCTTTTTTGGAAACTGAGGACCCAACAACTAACCACGTTTACACGACTTGAGT
TTTGAACCCCGATTAATGTCTGTACGTCACCTTTCCTAGTTCTGACCCTGAGCCCTGGGGAACAGGAAAGCGTGGCTGGCCTCTTGCACT
GCTTTGTCTCCAAAATAAACTACTGAAATCAAACCGCATTTCACACGTGTTTACACATGTTGCTCAAGTTTGTTATGTCATACTCCCAGT
CCTTAAAAGACGTTTAATAAAACAGCTTTACCTTTTAAAAATAAAATTTCAATCCCAGTCTGCCTCAGGTACGGGTGGGGGTGTGCAGCG
TGACTCCTGGCTGTGTTCCTGTACCGTTTGTGGCCTCCGGGGTCTTGCGCGTCCAGGGCCCAGATACCGAGTAACTGCCATGTGGTGTCG
TGGTGGCGTCCATAGGCCTCCGTGGTGGGGCGGGGGCGGGGCTGTGGGTGTGCAGGGCAGCTGCATTTTCCAAGAGTGGAGATGGAGGAT
GGAGATTTGCTTCGTAAAGGCCTGGGAGCTACATGGGAGGTAGGGAGGGGCCAGCCACACCCAGGGCTGGGGGGCCGGTGGACTCTGCCC
AGTGAAGCCAGGGGAGTGTCAGCAATGAGGGGCCTGGACAGCGACGCGGGACCCGCACCTGGGAGCGGCAGAGATGGAGCCCAGCTCGCT
AAACGTACCCTAAGGGTGCACGCTGACCATCTTTGATCCCTGGACAGTGTCCATAGAGTTGTCTCCCCTTCGGTCACATTGTCCCTGGCC
TTGGAGTTTCTGCCTCAGGGAAAGACCCACTAAAACCACCCGGGCTCTGGCGGCCTCCTCTTCTCCAGAGCATGGTGGCGCTGCCTCCTG
AGCAGAGTCACTGAGAGTGTCTGGGTCCAAGGAAGGGACCCACTTAGCAAAGGTTGTTGTGTGGTGCTGTGCAGGCACGGCGCCTGGAGT
TGGCCCCGCCAGCATCGGGGTGGCTTGGGGCTCTGGTTCCTAAGCTTCTGCTTCTGAGTTGGTCAGCACGTTGGCTCTGCGCCCTGCAGT
GCCTGTCTTGATGGTGGTCCCTGGATGTGCTGAAGGGCTCCAGGAGCAAGGGGCCAGACCACACTTTGGCTGAGTCCTTGGGTAGTTTCA
GAGGGTCACCTGCACAGTCTGCATTGAGCACCCTGGGGCTGAGGCCGTGGGTCAAGTTCTGCCTGACAGTGCTTTGATTATATGGTGATG
TGATTCTGCAAACATAACCCCCCAACTGAGTGCCAGCTGCTGGGTGTCCCCACCCCAAGAGCCAAGGGGAGGCCACCCTGGAACTGGTGC
TTTGCCCTTGGTGTCATGGAGGTGTCTGGGTCCACACGTGGTGGGTGGGCTGGGCCTGCAGTCACCCAGCATGGCCGGCGGGATTGGACC
CAGCTGCAACCTGGCAGGTTCCATGGGGCTTCCTGTGCCTGGGCCTGCCTGTGTCTCATGCCTGTCAATAAAGGAGAAAGCAACCTGGGA
AAAACATTCCTCTCTGTACCCAGGGGACTGCCAAGTGTGCTTTATAGAAGGCTGGAAGACCGACTGAAGTAGGAAGCTGTCACATGTTTG
AGCCAACTGAGCAAAGCAGCTGTTGCCTGCCAGACAGCCACCCCAAGACCAAGGGAGCCAGCCTGTCGTTTGTCCTTCTAGCCTGGAAGA
CCAGTTCTTGGCTCTTGGGCACTCACATTGGCCACTGGCCACAACTGCTGAATGGCTTCACTAATGTCCCTGGGGTCTGTATCTGCCCTC
TCTTCTATTCCCTAGAAACTCTGGCCGGGCATGGCGGCTCACGCCTGTCATCCCAGCACTTAGGGAGGCTGAGGCAGGTGGATCACAAGG
TCAAGAGATCGACACCATCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGACATGGTGGTGGGCGCCTG
TAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACTCGGGAGGCGTAGGTTGCAGTGAGCCAAGATCGCACCACTGCACT
CCAGCCTGGCAACAGAGCAAGACTCCTCAAAAAACAAACAAACAAACAAACAAACTCTGATCATTCACCCGGTGGGATCCCCGGCAGCTC
CTTCTCCTTCCCGAGCTGTGGCTCATGGGCCATTGGATTCAGAGACCTTGAGCTGGGTGCTGGCTGCCCTAAAGGAGCACGACCCCTCCA
GCCTGGTGACCGGGAGGCAGAGAAGTGCAGCTGTCCTTGACAAAGGCCCAGCCTCTGCTGCCTCAGGCCAGCCTGGCCACACCCCGATGC
CACAGTCATCTGCCCCGCCCAGGCATAAGCCTGACTCAGGTGATACAGGCGAGGCTTCTCCCATGGGTCCTCCCCTTGTGAGAAAGGGTC
TGTGCTGTGTACCTTCTCTCTGCACAGCCATTGTCAGTGTGGTTTGGAGTGAGTGAGCCTCCCGCACTGCTCAGGGGAGAGCTGGTGAGC
ATGACTCCATGGCCTCCTGCTGGTTGGGGTCTTCTTCTGATTCTCACCCGCAGGAGCACCCAGACCCCCCCTTTTCAGAAATGATTACAT
TTTCCCTTCAAGAGTCATCTGTGACCTGGTGGTGTGGAGGGACTGTCCCCTCCTGCAGCCTGGCCGACCCCCTTCCTCCAGGGCTGTGTG
GAATCACCTCTCAGAAGCTCACTCTGAAAAGCCACTCACAGGGATTTCACCAGGATGTTGCTGTTCCTGCCGACACCTGGGCTTTGTGAC
AAATGCTGTTTGCTTCAAGCTGTTCACAAGCAACTTCACCAGAATCCCAAGCTGGTTCGTACTTAATTTGTGTACATACATATGCATAAT
ATACATGACCATGTATGAGATACAGACACCATGGCTTCTGTCCATTGGCTCATTCGCCTGGTCGCATGTTCACTCCATGAGGTTAGGACA
CTGCGGGTGGCTTTGGGATGGGTGGTTTCAGGGACAAGGTGTCGCTATGATCTCTGTATTTGCTAACTAGTCTTGTTTTGATTTCTAACG
GTCTAGTGGAGTACAGTTAATGTTGTGTTTATTTCTGTAACTGTAGGGGTGGAGTATAAACCTAACTTTTGGAAACATGAAGAAATAAAC

>3466_3466_4_AKT1-ITPK1_AKT1_chr14_105258935_ENST00000555528_ITPK1_chr14_93542964_ENST00000267615_length(amino acids)=529AA_BP=146
MWFRRGLGFLPGGFWACAGGLWTPVCASGLHPGPVFLMFEFLCFPSLGSREEPCALSQDPWVGTPWTGRANGAICHQGLREGRASLGQRS
QRGCLEEAACQLVHQRLWPGQLGSGSASLRGARERRGSLGHHERRGYCEGGLAAQTRKRGMEVVQLNLSRPIEEQGPLDVIIHKLTDVIL
EADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSYELIRKIEAYMEDDRICSPPFMELTSLCGDDTMRLLEKNGLTFPFI
CKTRVAHGTNSHEMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLT
ELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIATVLQGQSTAMAATGDVAL

--------------------------------------------------------------
>3466_3466_5_AKT1-ITPK1_AKT1_chr14_105258935_ENST00000555528_ITPK1_chr14_93542964_ENST00000354313_length(transcript)=3118nt_BP=699nt
ATGGATAAAGTGTGCTCAGGTGAGGGTTGGCTGGTGGGCCGCTGCAGGGCGGGGGCCTGTCCAGTGCTCCCCCACTTACTTGCTGCCTCC
CGACTGCTGTAATTATGGGTCTGTAACCACCCTGGACTGGGTGCTCCTCACTGACGGACTTGTCTGAACCTCTCTTTGTCTCCAGCGCCC
AGCACTGGGCCTGGCAAAACCTGAGACGCCCGGTACATGTTGGCCAAATGAATGAACCAGATTCAGACCGGCAGGGGCGCTGTGGTTTAG
GAGGGGCCTGGGGTTTCTCCCAGGAGGTTTTTGGGCTTGCGCTGGAGGGCTCTGGACTCCCGTTTGCGCCAGTGGCCTGCATCCTGGTCC
TGTCTTCCTCATGTTTGAATTTCTTTGCTTTCCTAGTCTGGGGAGCAGGGAGGAGCCCTGTGCCCTGTCCCAGGATCCATGGGTAGGAAC
ACCATGGACAGGGAGAGCAAACGGGGCCATCTGTCACCAGGGGCTTAGGGAAGGCCGAGCCAGCCTGGGTCAAAGAAGTCAAAGGGGCTG
CCTGGAGGAGGCAGCCTGTCAGCTGGTGCATCAGAGGCTGTGGCCAGGCCAGCTGGGCTCGGGGAGCGCCAGCCTGAGAGGAGCGCGTGA
GCGTCGCGGGAGCCTCGGGCACCATGAGCGACGTGGCTATTGTGAAGGAGGGTTGGCTGCACAAACGAGGAAGCGAGGGATGGAGGTTGT
GCAGCTGAACCTTAGCCGGCCGATCGAGGAGCAGGGCCCCCTGGACGTCATCATCCACAAGCTGACTGACGTCATCCTTGAAGCCGACCA
GAATGATAGCCAGTCCCTGGAGCTGGTGCACAGGTTCCAGGAGTACATCGATGCCCACCCTGAGACCATCGTCCTGGACCCGCTCCCTGC
CATCAGAACCCTGCTTGACCGCTCCAAGTCCTATGAGCTCATCCGGAAGATTGAGGCCTACATGGAAGACGACAGGATCTGCTCGCCACC
CTTCATGGAGCTCACGAGCCTGTGCGGGGATGACACCATGCGGCTGCTGGAGAAGAACGGCTTGACTTTCCCATTCATTTGCAAAACCAG
AGTGGCTCATGGCACCAACTCTCACGAGATGGCTATCGTGTTCAACCAGGAGGGCCTGAACGCCATCCAGCCACCCTGCGTGGTCCAGAA
TTTCATCAACCACAACGCCGTCCTGTACAAGGTGTTCGTGGTTGGCGAGTCCTACACCGTGGTCCAGAGGCCCTCACTCAAGAACTTCTC
CGCAGGCACATCAGACCGTGAGTCCATCTTCTTCAACAGCCACAACGTGTCAAAGCCGGAGTCGTCATCGGTCCTGACGGAGCTGGACAA
GATCGAGGGCGTGTTCGAGCGGCCGAGCGACGAGGTCATCCGGGAGCTCTCCCGGGCCCTGCGGCAGGCACTGGGCGTGTCACTCTTCGG
CATCGACATCATCATCAACAACCAGACAGGGCAGCACGCCGTCATTGACATCAATGCCTTCCCAGGGGACTGCCAAGTGTGCTTTATAGA
AGGCTGGAAGACCGACTGAAGTAGGAAGCTGTCACATGTTTGAGCCAACTGAGCAAAGCAGCTGTTGCCTGCCAGACAGCCACCCCAAGA
CCAAGGGAGCCAGCCTGTCGTTTGTCCTTCTAGCCTGGAAGACCAGTTCTTGGCTCTTGGGCACTCACATTGGCCACTGGCCACAACTGC
TGAATGGCTTCACTAATGTCCCTGGGGTCTGTATCTGCCCTCTCTTCTATTCCCTAGAAACTCTGGCCGGGCATGGCGGCTCACGCCTGT
CATCCCAGCACTTAGGGAGGCTGAGGCAGGTGGATCACAAGGTCAAGAGATCGACACCATCCTGGCCAACATGGTGAAACCCCATCTCTA
CTAAAAATACAAAAATTAGCTGGACATGGTGGTGGGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACTCG
GGAGGCGTAGGTTGCAGTGAGCCAAGATCGCACCACTGCACTCCAGCCTGGCAACAGAGCAAGACTCCTCAAAAAACAAACAAACAAACA
AACAAACTCTGATCATTCACCCGGTGGGATCCCCGGCAGCTCCTTCTCCTTCCCGAGCTGTGGCTCATGGGCCATTGGATTCAGAGACCT
TGAGCTGGGTGCTGGCTGCCCTAAAGGAGCACGACCCCTCCAGCCTGGTGACCGGGAGGCAGAGAAGTGCAGCTGTCCTTGACAAAGGCC
CAGCCTCTGCTGCCTCAGGCCAGCCTGGCCACACCCCGATGCCACAGTCATCTGCCCCGCCCAGGCATAAGCCTGACTCAGGTGATACAG
GCGAGGCTTCTCCCATGGGTCCTCCCCTTGTGAGAAAGGGTCTGTGCTGTGTACCTTCTCTCTGCACAGCCATTGTCAGTGTGGTTTGGA
GTGAGTGAGCCTCCCGCACTGCTCAGGGGAGAGCTGGTGAGCATGACTCCATGGCCTCCTGCTGGTTGGGGTCTTCTTCTGATTCTCACC
CGCAGGAGCACCCAGACCCCCCCTTTTCAGAAATGATTACATTTTCCCTTCAAGAGTCATCTGTGACCTGGTGGTGTGGAGGGACTGTCC
CCTCCTGCAGCCTGGCCGACCCCCTTCCTCCAGGGCTGTGTGGAATCACCTCTCAGAAGCTCACTCTGAAAAGCCACTCACAGGGATTTC
ACCAGGATGTTGCTGTTCCTGCCGACACCTGGGCTTTGTGACAAATGCTGTTTGCTTCAAGCTGTTCACAAGCAACTTCACCAGAATCCC
AAGCTGGTTCGTACTTAATTTGTGTACATACATATGCATAATATACATGACCATGTATGAGATACAGACACCATGGCTTCTGTCCATTGG
CTCATTCGCCTGGTCGCATGTTCACTCCATGAGGTTAGGACACTGCGGGTGGCTTTGGGATGGGTGGTTTCAGGGACAAGGTGTCGCTAT
GATCTCTGTATTTGCTAACTAGTCTTGTTTTGATTTCTAACGGTCTAGTGGAGTACAGTTAATGTTGTGTTTATTTCTGTAACTGTAGGG

>3466_3466_5_AKT1-ITPK1_AKT1_chr14_105258935_ENST00000555528_ITPK1_chr14_93542964_ENST00000354313_length(amino acids)=429AA_BP=146
MWFRRGLGFLPGGFWACAGGLWTPVCASGLHPGPVFLMFEFLCFPSLGSREEPCALSQDPWVGTPWTGRANGAICHQGLREGRASLGQRS
QRGCLEEAACQLVHQRLWPGQLGSGSASLRGARERRGSLGHHERRGYCEGGLAAQTRKRGMEVVQLNLSRPIEEQGPLDVIIHKLTDVIL
EADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSYELIRKIEAYMEDDRICSPPFMELTSLCGDDTMRLLEKNGLTFPFI
CKTRVAHGTNSHEMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLT

--------------------------------------------------------------
>3466_3466_6_AKT1-ITPK1_AKT1_chr14_105258935_ENST00000555528_ITPK1_chr14_93542964_ENST00000556603_length(transcript)=3657nt_BP=699nt
ATGGATAAAGTGTGCTCAGGTGAGGGTTGGCTGGTGGGCCGCTGCAGGGCGGGGGCCTGTCCAGTGCTCCCCCACTTACTTGCTGCCTCC
CGACTGCTGTAATTATGGGTCTGTAACCACCCTGGACTGGGTGCTCCTCACTGACGGACTTGTCTGAACCTCTCTTTGTCTCCAGCGCCC
AGCACTGGGCCTGGCAAAACCTGAGACGCCCGGTACATGTTGGCCAAATGAATGAACCAGATTCAGACCGGCAGGGGCGCTGTGGTTTAG
GAGGGGCCTGGGGTTTCTCCCAGGAGGTTTTTGGGCTTGCGCTGGAGGGCTCTGGACTCCCGTTTGCGCCAGTGGCCTGCATCCTGGTCC
TGTCTTCCTCATGTTTGAATTTCTTTGCTTTCCTAGTCTGGGGAGCAGGGAGGAGCCCTGTGCCCTGTCCCAGGATCCATGGGTAGGAAC
ACCATGGACAGGGAGAGCAAACGGGGCCATCTGTCACCAGGGGCTTAGGGAAGGCCGAGCCAGCCTGGGTCAAAGAAGTCAAAGGGGCTG
CCTGGAGGAGGCAGCCTGTCAGCTGGTGCATCAGAGGCTGTGGCCAGGCCAGCTGGGCTCGGGGAGCGCCAGCCTGAGAGGAGCGCGTGA
GCGTCGCGGGAGCCTCGGGCACCATGAGCGACGTGGCTATTGTGAAGGAGGGTTGGCTGCACAAACGAGGAAGCGAGGGATGGAGGTTGT
GCAGCTGAACCTTAGCCGGCCGATCGAGGAGCAGGGCCCCCTGGACGTCATCATCCACAAGCTGACTGACGTCATCCTTGAAGCCGACCA
GAATGATAGCCAGTCCCTGGAGCTGGTGCACAGGTTCCAGGAGTACATCGATGCCCACCCTGAGACCATCGTCCTGGACCCGCTCCCTGC
CATCAGAACCCTGCTTGACCGCTCCAAGTCCTATGAGCTCATCCGGAAGATTGAGGCCTACATGGAAGACGACAGGATCTGCTCGCCACC
CTTCATGGAGCTCACGAGCCTGTGCGGGGATGACACCATGCGGCTGCTGGAGAAGAACGGCTTGACTTTCCCATTCATTTGCAAAACCAG
AGTGGCTCATGGCACCAACTCTCACGAGATGGCTATCGTGTTCAACCAGGAGGGCCTGAACGCCATCCAGCCACCCTGCGTGGTCCAGAA
TTTCATCAACCACAACGCCGTCCTGTACAAGGTGTTCGTGGTTGGCGAGTCCTACACCGTGGTCCAGAGGCCCTCACTCAAGAACTTCTC
CGCAGGCACATCAGACCGTGAGTCCATCTTCTTCAACAGCCACAACGTGTCAAAGCCGGAGTCGTCATCGGTCCTGACGGAGCTGGACAA
GATCGAGGGCGTGTTCGAGCGGCCGAGCGACGAGGTCATCCGGGAGCTCTCCCGGGCCCTGCGGCAGGCACTGGGCGTGTCACTCTTCGG
CATCGACATCATCATCAACAACCAGACAGGGCAGCACGCCGTCATTGACATCAATGCCTTCCCAGGCTACGAGGGCGTGAGCGAGTTCTT
CACAGACCTCCTGAACCACATCGCCACTGTCCTGCAGGGCCAGAGCACAGCCATGGCAGCCACAGGGGACGTGGCCCTGCTGAGGCACAG
CAAGCTTCTGGCCGAGCCGGCGGGCGGCCTGGTGGGCGAGCGGACATGCAGCGCCAGCCCCGGCTGCTGCGGCAGCATGATGGGCCAGGA
CGCGCCCTGGAAGGCTGAGGCCGACGCGGGCGGCACCGCCAAGCTGCCGCACCAGAGACTCGGCTGCAACGCCGGCGTGTCGCCCAGCTT
CCAGCAGCATTGTGTGGCCTCCCTGGCCACCAAGGCCTCCTCCCAGTAGCCACGGAGCCGGGACCCAGAGGGGCAGCGCAGGGCGCAGAG
CACACCCGCTGGGCCAGCAGCTCCCAACGGCGATGCTACTACTAAGAATCCCCAGTGATCTGATTCTTCTGTTTTTTAATTTTTAACCTG
ATTCTCTGATGTCATGATCTAAATGAGGGGTAGTGGGGGATGGAAGAGAGTACCAGGTGGTCCACCGTTGGGGAGTGGGGCCGTCCGCCT
GCTCTCTACTGTGCAGACCTCCTAACTGAGTTTACACACGCTTGTGTTTGCAACACTAGGTCTGGATGGGAGGTGAGGGGTGTGCGTATG
GCTGCCATGCCAGTGTCTGTGCACATCCCTGTCTGTTGGTCTCCATGGCCACTGTGGACCGGGACCCTTGGGGGAAGCCTGCCCATGTCG
GGCTGTGGGAGGCTGATCGGTGCATGTGAGAGTGGCTTCCCTTCTGCCTGACTCCCCACTCCCTGACCTGCCCCTTCCTTGTTTTTCCTC
CTACTGGTCTCCACCAAGGCTTTGTTAGCCCCCACCCTGCCTGGTGTGCAGCTAACCCCTCCCTCCCCACAGCCAGAGGAGGCCACAGAC
CCCTCAGGGGAGTTCCGCGCTGGGGTCTGGGCTGTGCTCCCTCACTAAAGGGAAGGAAAGGAAGCTGGGCGTCCTCTGGGCCCCCCAACA
CACGTCCCATTTAGCCCTGCACAGCGGTCTCCTTCCCCTAAGCCAGCACTGCTGCTCCCTGGAGCCCGGGAAGGAGGCTGCCTGGCTGGA
GGCCCGAGCCGATGGCGCCTGTGCTGAGGATTTGTGCTGTGATTTGGGCAAATCATTCCAGGTCTTTGGGCCTCCACCCCCTTGTCTCTA
GTGGACATTTGAGATCAGAGAGCACCACAGGGCTGGCTTTGTGCCCTAACCCCTGGGATGCAGCCTGCCTTTCCATAAAGTCACCTAGGT
GAGGATAGGCGCGGGAGCCTCGGCATGACACCATGGAGATCGGGGCCCTCTTCCCAGTGGGTTCACTCCTTTTCACACCTGCTGGGTCCC
TCCTCACCCAGCAGGCCTGGTCCACCTCTCATTGCAAGCCCCAAGCACTGAGCCAGCAGGTGCCAGGGAGCCACCCGCCCCCCATCGCTT
CTGCACACCTCAGACTCACCCCATCACCTTGGCAGCAAAGCACTGGCTCTGCCGTCTGACCCCTGATCCAGGCAGCCCCCTCTGCAGAGA
AAAGGGTTGGGGAGAAGCCTCTGCAGTCCTGGAAGATGTGGGGTGCTGGGTGAGAGGCATCAGCCCCCACAAGTATGTTTTTGTGTCTTA
AGATAGCAGTTTACTTTGAAAAAGTGAAAAAGGCTTCCGGGCTGTCCTCTGCCCAGTGAGATGGAGGACGCTAGAGAAAGTGCTGAGTGT
CCCGAGAGAGGCCCCCGAGCCAGTGCATGGAGGTCCTTCGGCCTGGCTCAGCTGGGCTGCAGGATGCCCACTTTGAGGAGGGAGGCACAG
GGCTTGGGCGAGGGGCAGAGGCCATCAGAACTGCCCGGCTTTTTTGGAAACTGAGGACCCAACAACTAACCACGTTTACACGACTTGAGT
TTTGAACCCCGATTAATGTCTGTACGTCACCTTTCCTAGTTCTGACCCTGAGCCCTGGGGAACAGGAAAGCGTGGCTGGCCTCTTGCACT
GCTTTGTCTCCAAAATAAACTACTGAAATCAAACCGCATTTCACACGTGTTTACACATGTTGCTCAAGTTTGTTATGTCATACTCCCAGT

>3466_3466_6_AKT1-ITPK1_AKT1_chr14_105258935_ENST00000555528_ITPK1_chr14_93542964_ENST00000556603_length(amino acids)=529AA_BP=146
MWFRRGLGFLPGGFWACAGGLWTPVCASGLHPGPVFLMFEFLCFPSLGSREEPCALSQDPWVGTPWTGRANGAICHQGLREGRASLGQRS
QRGCLEEAACQLVHQRLWPGQLGSGSASLRGARERRGSLGHHERRGYCEGGLAAQTRKRGMEVVQLNLSRPIEEQGPLDVIIHKLTDVIL
EADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSYELIRKIEAYMEDDRICSPPFMELTSLCGDDTMRLLEKNGLTFPFI
CKTRVAHGTNSHEMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLT
ELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIATVLQGQSTAMAATGDVAL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for AKT1-ITPK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for AKT1-ITPK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for AKT1-ITPK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource