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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GRB7-ERBB2 (FusionGDB2 ID:34663)

Fusion Gene Summary for GRB7-ERBB2

Fusion gene summary

Fusion gene information	Fusion gene name: GRB7-ERBB2
	Fusion gene ID: 34663
		Hgene	Tgene
	Gene symbol	GRB7	ERBB2
	Gene ID	2886	2064
	Gene name	growth factor receptor bound protein 7	erb-b2 receptor tyrosine kinase 2
	Synonyms	-	CD340\|HER-2\|HER-2/neu\|HER2\|MLN 19\|NEU\|NGL\|TKR1
	Cytomap	17q12	17q12
	Type of gene	protein-coding	protein-coding
	Description	growth factor receptor-bound protein 7B47GRB7 adapter proteinepidermal growth factor receptor GRB-7	receptor tyrosine-protein kinase erbB-2c-erb B2/neu proteinherstatinhuman epidermal growth factor receptor 2metastatic lymph node gene 19 proteinneuro/glioblastoma derived oncogene homologneuroblastoma/glioblastoma derived oncogene homologp185erbB2
	Modification date	20200313	20200329
	UniProtAcc	.	P04626
	Ensembl transtripts involved in fusion gene	ENST00000578702, ENST00000309185, ENST00000394204, ENST00000309156, ENST00000394209, ENST00000394211, ENST00000445327,	ENST00000584888, ENST00000578199, ENST00000584601, ENST00000269571, ENST00000406381, ENST00000540042, ENST00000540147, ENST00000541774, ENST00000584450, ENST00000445658,
Fusion gene scores	* DoF score	23 X 20 X 8=3680	34 X 40 X 10=13600
	# samples	42	43
	** MAII score	log2(42/3680*10)=-3.13124453327825 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(43/13600*10)=-4.9831261814356 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GRB7 [Title/Abstract] AND ERBB2 [Title/Abstract] AND fusion [Title/Abstract] Relapsed classic E-Cadherin (CDH1)-mutated invasive lobular breast cancer shows a high frequency of HER2 (ERBB2) gene mutations (pmid: 23575477)
Most frequent breakpoint	GRB7(37894386)-ERBB2(37844949), # samples:2 GRB7(37898709)-ERBB2(37863243), # samples:2
Anticipated loss of major functional domain due to fusion event.	GRB7-ERBB2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. GRB7-ERBB2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. GRB7-ERBB2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GRB7	GO:0030335	positive regulation of cell migration	10893408\|12021278
Tgene	ERBB2	GO:0007165	signal transduction	10572067
Tgene	ERBB2	GO:0007166	cell surface receptor signaling pathway	9685399
Tgene	ERBB2	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	7514177
Tgene	ERBB2	GO:0014065	phosphatidylinositol 3-kinase signaling	7556068
Tgene	ERBB2	GO:0018108	peptidyl-tyrosine phosphorylation	12000754
Tgene	ERBB2	GO:0032886	regulation of microtubule-based process	20937854
Tgene	ERBB2	GO:0035556	intracellular signal transduction	19372587
Tgene	ERBB2	GO:0042060	wound healing	12646923
Tgene	ERBB2	GO:0043406	positive regulation of MAP kinase activity	10572067
Tgene	ERBB2	GO:0045785	positive regulation of cell adhesion	7556068
Tgene	ERBB2	GO:0046777	protein autophosphorylation	7556068
Tgene	ERBB2	GO:0050679	positive regulation of epithelial cell proliferation	10572067
Tgene	ERBB2	GO:0071363	cellular response to growth factor stimulus	20010870
Tgene	ERBB2	GO:0090314	positive regulation of protein targeting to membrane	20010870

Fusion gene breakpoints across GRB7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ERBB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-GU-AATP-01A	GRB7	chr17	37894386	-	ERBB2	chr17	37844949	+
ChimerDB4	BLCA	TCGA-GU-AATP	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
ChimerDB4	BRCA	TCGA-C8-A1HK-01A	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
ChimerDB4	CESC	TCGA-C5-A1M9-01A	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
ChimerDB4	CESC	TCGA-LP-A5U3-01A	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
ChimerDB4	CESC	TCGA-LP-A5U3-01A	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
ChimerDB4	CESC	TCGA-LP-A5U3-01A	GRB7	chr17	37898709	-	ERBB2	chr17	37863243	+
ChimerDB4	CESC	TCGA-LP-A5U3-01A	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
ChimerDB4	CESC	TCGA-VS-A9V5	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
ChimerDB4	CESC	TCGA-VS-A9V5	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+

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Fusion Gene ORF analysis for GRB7-ERBB2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3UTR	ENST00000578702	ENST00000584888	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
3UTR-5UTR	ENST00000309185	ENST00000578199	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
3UTR-5UTR	ENST00000309185	ENST00000584601	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
3UTR-5UTR	ENST00000394204	ENST00000578199	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
3UTR-5UTR	ENST00000394204	ENST00000584601	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
3UTR-5UTR	ENST00000578702	ENST00000269571	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
3UTR-5UTR	ENST00000578702	ENST00000406381	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
3UTR-5UTR	ENST00000578702	ENST00000540042	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
3UTR-5UTR	ENST00000578702	ENST00000540147	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
3UTR-5UTR	ENST00000578702	ENST00000541774	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
3UTR-5UTR	ENST00000578702	ENST00000578199	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
3UTR-5UTR	ENST00000578702	ENST00000584450	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
3UTR-5UTR	ENST00000578702	ENST00000584601	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
3UTR-5UTR	ENST00000578702	ENST00000584601	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
3UTR-intron	ENST00000309185	ENST00000269571	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
3UTR-intron	ENST00000309185	ENST00000406381	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
3UTR-intron	ENST00000309185	ENST00000445658	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
3UTR-intron	ENST00000309185	ENST00000540042	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
3UTR-intron	ENST00000309185	ENST00000540147	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
3UTR-intron	ENST00000309185	ENST00000541774	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
3UTR-intron	ENST00000309185	ENST00000584450	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
3UTR-intron	ENST00000309185	ENST00000584888	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
3UTR-intron	ENST00000394204	ENST00000269571	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
3UTR-intron	ENST00000394204	ENST00000406381	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
3UTR-intron	ENST00000394204	ENST00000445658	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
3UTR-intron	ENST00000394204	ENST00000540042	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
3UTR-intron	ENST00000394204	ENST00000540147	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
3UTR-intron	ENST00000394204	ENST00000541774	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
3UTR-intron	ENST00000394204	ENST00000584450	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
3UTR-intron	ENST00000394204	ENST00000584888	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
3UTR-intron	ENST00000578702	ENST00000269571	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
3UTR-intron	ENST00000578702	ENST00000269571	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
3UTR-intron	ENST00000578702	ENST00000406381	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
3UTR-intron	ENST00000578702	ENST00000406381	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
3UTR-intron	ENST00000578702	ENST00000445658	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
3UTR-intron	ENST00000578702	ENST00000445658	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
3UTR-intron	ENST00000578702	ENST00000445658	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
3UTR-intron	ENST00000578702	ENST00000540042	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
3UTR-intron	ENST00000578702	ENST00000540042	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
3UTR-intron	ENST00000578702	ENST00000540147	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
3UTR-intron	ENST00000578702	ENST00000540147	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
3UTR-intron	ENST00000578702	ENST00000541774	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
3UTR-intron	ENST00000578702	ENST00000541774	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
3UTR-intron	ENST00000578702	ENST00000578199	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
3UTR-intron	ENST00000578702	ENST00000578199	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
3UTR-intron	ENST00000578702	ENST00000584450	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
3UTR-intron	ENST00000578702	ENST00000584450	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
3UTR-intron	ENST00000578702	ENST00000584601	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
3UTR-intron	ENST00000578702	ENST00000584888	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
3UTR-intron	ENST00000578702	ENST00000584888	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000309156	ENST00000269571	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000309156	ENST00000406381	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000309156	ENST00000540042	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000309156	ENST00000540147	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000309156	ENST00000541774	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000309156	ENST00000578199	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-5UTR	ENST00000309156	ENST00000578199	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000309156	ENST00000584450	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000309156	ENST00000584601	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-5UTR	ENST00000309156	ENST00000584601	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-5UTR	ENST00000309156	ENST00000584601	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000309185	ENST00000269571	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000309185	ENST00000406381	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000309185	ENST00000540042	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000309185	ENST00000540147	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000309185	ENST00000541774	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000309185	ENST00000578199	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000309185	ENST00000584450	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000309185	ENST00000584601	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-5UTR	ENST00000309185	ENST00000584601	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000394204	ENST00000269571	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000394204	ENST00000406381	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000394204	ENST00000540042	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000394204	ENST00000540147	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000394204	ENST00000541774	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000394204	ENST00000578199	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000394204	ENST00000584450	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000394204	ENST00000584601	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-5UTR	ENST00000394204	ENST00000584601	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000394209	ENST00000269571	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000394209	ENST00000406381	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000394209	ENST00000540042	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000394209	ENST00000540147	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000394209	ENST00000541774	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000394209	ENST00000578199	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-5UTR	ENST00000394209	ENST00000578199	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000394209	ENST00000584450	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000394209	ENST00000584601	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-5UTR	ENST00000394209	ENST00000584601	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-5UTR	ENST00000394209	ENST00000584601	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000394211	ENST00000269571	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000394211	ENST00000406381	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000394211	ENST00000540042	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000394211	ENST00000540147	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000394211	ENST00000541774	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000394211	ENST00000578199	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-5UTR	ENST00000394211	ENST00000578199	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000394211	ENST00000584450	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000394211	ENST00000584601	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-5UTR	ENST00000394211	ENST00000584601	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-5UTR	ENST00000394211	ENST00000584601	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000445327	ENST00000269571	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000445327	ENST00000406381	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000445327	ENST00000540042	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000445327	ENST00000540147	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000445327	ENST00000541774	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000445327	ENST00000578199	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-5UTR	ENST00000445327	ENST00000578199	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000445327	ENST00000584450	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-5UTR	ENST00000445327	ENST00000584601	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-5UTR	ENST00000445327	ENST00000584601	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-5UTR	ENST00000445327	ENST00000584601	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-intron	ENST00000309156	ENST00000269571	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-intron	ENST00000309156	ENST00000269571	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000309156	ENST00000406381	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-intron	ENST00000309156	ENST00000406381	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000309156	ENST00000445658	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-intron	ENST00000309156	ENST00000445658	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000309156	ENST00000445658	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-intron	ENST00000309156	ENST00000540042	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
5CDS-intron	ENST00000309156	ENST00000540042	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-intron	ENST00000309156	ENST00000540042	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000309156	ENST00000540147	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-intron	ENST00000309156	ENST00000540147	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000309156	ENST00000541774	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-intron	ENST00000309156	ENST00000541774	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000309156	ENST00000578199	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
5CDS-intron	ENST00000309156	ENST00000578199	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000309156	ENST00000584450	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-intron	ENST00000309156	ENST00000584450	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000309156	ENST00000584888	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
5CDS-intron	ENST00000309156	ENST00000584888	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-intron	ENST00000309156	ENST00000584888	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000309156	ENST00000584888	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-intron	ENST00000309185	ENST00000269571	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000309185	ENST00000406381	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000309185	ENST00000445658	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000309185	ENST00000445658	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-intron	ENST00000309185	ENST00000540042	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000309185	ENST00000540147	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000309185	ENST00000541774	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000309185	ENST00000578199	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000309185	ENST00000584450	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000309185	ENST00000584888	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000309185	ENST00000584888	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-intron	ENST00000394204	ENST00000269571	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000394204	ENST00000406381	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000394204	ENST00000445658	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000394204	ENST00000445658	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-intron	ENST00000394204	ENST00000540042	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000394204	ENST00000540147	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000394204	ENST00000541774	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000394204	ENST00000578199	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000394204	ENST00000584450	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000394204	ENST00000584888	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000394204	ENST00000584888	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-intron	ENST00000394209	ENST00000269571	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-intron	ENST00000394209	ENST00000269571	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000394209	ENST00000406381	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-intron	ENST00000394209	ENST00000406381	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000394209	ENST00000445658	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-intron	ENST00000394209	ENST00000445658	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000394209	ENST00000445658	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-intron	ENST00000394209	ENST00000540042	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
5CDS-intron	ENST00000394209	ENST00000540042	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-intron	ENST00000394209	ENST00000540042	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000394209	ENST00000540147	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-intron	ENST00000394209	ENST00000540147	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000394209	ENST00000541774	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-intron	ENST00000394209	ENST00000541774	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000394209	ENST00000578199	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
5CDS-intron	ENST00000394209	ENST00000578199	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000394209	ENST00000584450	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-intron	ENST00000394209	ENST00000584450	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000394209	ENST00000584888	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
5CDS-intron	ENST00000394209	ENST00000584888	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-intron	ENST00000394209	ENST00000584888	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000394209	ENST00000584888	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-intron	ENST00000394211	ENST00000269571	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-intron	ENST00000394211	ENST00000269571	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000394211	ENST00000406381	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-intron	ENST00000394211	ENST00000406381	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000394211	ENST00000445658	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-intron	ENST00000394211	ENST00000445658	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000394211	ENST00000445658	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-intron	ENST00000394211	ENST00000540042	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
5CDS-intron	ENST00000394211	ENST00000540042	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-intron	ENST00000394211	ENST00000540042	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000394211	ENST00000540147	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-intron	ENST00000394211	ENST00000540147	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000394211	ENST00000541774	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-intron	ENST00000394211	ENST00000541774	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000394211	ENST00000578199	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
5CDS-intron	ENST00000394211	ENST00000578199	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000394211	ENST00000584450	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-intron	ENST00000394211	ENST00000584450	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000394211	ENST00000584888	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
5CDS-intron	ENST00000394211	ENST00000584888	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-intron	ENST00000394211	ENST00000584888	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000394211	ENST00000584888	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-intron	ENST00000445327	ENST00000269571	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-intron	ENST00000445327	ENST00000269571	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000445327	ENST00000406381	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-intron	ENST00000445327	ENST00000406381	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000445327	ENST00000445658	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-intron	ENST00000445327	ENST00000445658	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000445327	ENST00000445658	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5CDS-intron	ENST00000445327	ENST00000540042	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
5CDS-intron	ENST00000445327	ENST00000540042	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-intron	ENST00000445327	ENST00000540042	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000445327	ENST00000540147	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-intron	ENST00000445327	ENST00000540147	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000445327	ENST00000541774	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-intron	ENST00000445327	ENST00000541774	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000445327	ENST00000578199	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
5CDS-intron	ENST00000445327	ENST00000578199	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000445327	ENST00000584450	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-intron	ENST00000445327	ENST00000584450	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000445327	ENST00000584888	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
5CDS-intron	ENST00000445327	ENST00000584888	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
5CDS-intron	ENST00000445327	ENST00000584888	GRB7	chr17	37898709	+	ERBB2	chr17	37855790	+
5CDS-intron	ENST00000445327	ENST00000584888	GRB7	chr17	37898709	+	ERBB2	chr17	37863243	+
5UTR-3UTR	ENST00000309156	ENST00000584888	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
5UTR-3UTR	ENST00000309185	ENST00000584888	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
5UTR-3UTR	ENST00000394211	ENST00000584888	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
5UTR-5UTR	ENST00000309156	ENST00000406381	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
5UTR-5UTR	ENST00000309156	ENST00000578199	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
5UTR-5UTR	ENST00000309156	ENST00000584601	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
5UTR-5UTR	ENST00000309185	ENST00000406381	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
5UTR-5UTR	ENST00000309185	ENST00000578199	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
5UTR-5UTR	ENST00000309185	ENST00000584601	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
5UTR-intron	ENST00000309156	ENST00000269571	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
5UTR-intron	ENST00000309156	ENST00000269571	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
5UTR-intron	ENST00000309156	ENST00000406381	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
5UTR-intron	ENST00000309156	ENST00000445658	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
5UTR-intron	ENST00000309156	ENST00000445658	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
5UTR-intron	ENST00000309156	ENST00000540042	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
5UTR-intron	ENST00000309156	ENST00000540042	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
5UTR-intron	ENST00000309156	ENST00000540147	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
5UTR-intron	ENST00000309156	ENST00000540147	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
5UTR-intron	ENST00000309156	ENST00000541774	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
5UTR-intron	ENST00000309156	ENST00000541774	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
5UTR-intron	ENST00000309156	ENST00000578199	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
5UTR-intron	ENST00000309156	ENST00000584450	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
5UTR-intron	ENST00000309156	ENST00000584450	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
5UTR-intron	ENST00000309156	ENST00000584601	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
5UTR-intron	ENST00000309156	ENST00000584888	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
5UTR-intron	ENST00000309185	ENST00000269571	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
5UTR-intron	ENST00000309185	ENST00000269571	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
5UTR-intron	ENST00000309185	ENST00000406381	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
5UTR-intron	ENST00000309185	ENST00000445658	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
5UTR-intron	ENST00000309185	ENST00000445658	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
5UTR-intron	ENST00000309185	ENST00000540042	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
5UTR-intron	ENST00000309185	ENST00000540042	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
5UTR-intron	ENST00000309185	ENST00000540147	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
5UTR-intron	ENST00000309185	ENST00000540147	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
5UTR-intron	ENST00000309185	ENST00000541774	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
5UTR-intron	ENST00000309185	ENST00000541774	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
5UTR-intron	ENST00000309185	ENST00000578199	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
5UTR-intron	ENST00000309185	ENST00000584450	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
5UTR-intron	ENST00000309185	ENST00000584450	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
5UTR-intron	ENST00000309185	ENST00000584601	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
5UTR-intron	ENST00000309185	ENST00000584888	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
5UTR-intron	ENST00000394211	ENST00000269571	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
5UTR-intron	ENST00000394211	ENST00000406381	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
5UTR-intron	ENST00000394211	ENST00000445658	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
5UTR-intron	ENST00000394211	ENST00000540042	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
5UTR-intron	ENST00000394211	ENST00000540147	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
5UTR-intron	ENST00000394211	ENST00000541774	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
5UTR-intron	ENST00000394211	ENST00000578199	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
5UTR-intron	ENST00000394211	ENST00000584450	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
5UTR-intron	ENST00000394211	ENST00000584601	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
Frame-shift	ENST00000309156	ENST00000269571	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
Frame-shift	ENST00000309156	ENST00000406381	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
Frame-shift	ENST00000309156	ENST00000445658	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
Frame-shift	ENST00000309156	ENST00000540147	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
Frame-shift	ENST00000309156	ENST00000541774	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
Frame-shift	ENST00000309156	ENST00000584450	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
Frame-shift	ENST00000309156	ENST00000584601	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
Frame-shift	ENST00000394209	ENST00000269571	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
Frame-shift	ENST00000394209	ENST00000406381	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
Frame-shift	ENST00000394209	ENST00000445658	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
Frame-shift	ENST00000394209	ENST00000540147	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
Frame-shift	ENST00000394209	ENST00000541774	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
Frame-shift	ENST00000394209	ENST00000584450	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
Frame-shift	ENST00000394209	ENST00000584601	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
Frame-shift	ENST00000394211	ENST00000269571	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
Frame-shift	ENST00000394211	ENST00000406381	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
Frame-shift	ENST00000394211	ENST00000445658	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
Frame-shift	ENST00000394211	ENST00000540147	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
Frame-shift	ENST00000394211	ENST00000541774	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
Frame-shift	ENST00000394211	ENST00000584450	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
Frame-shift	ENST00000394211	ENST00000584601	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
Frame-shift	ENST00000445327	ENST00000269571	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
Frame-shift	ENST00000445327	ENST00000406381	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
Frame-shift	ENST00000445327	ENST00000445658	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
Frame-shift	ENST00000445327	ENST00000540147	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
Frame-shift	ENST00000445327	ENST00000541774	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
Frame-shift	ENST00000445327	ENST00000584450	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
Frame-shift	ENST00000445327	ENST00000584601	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
intron-3CDS	ENST00000309156	ENST00000269571	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000309156	ENST00000406381	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000309156	ENST00000445658	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000309156	ENST00000540147	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000309156	ENST00000541774	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000309156	ENST00000584450	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000309156	ENST00000584601	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000309185	ENST00000269571	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
intron-3CDS	ENST00000309185	ENST00000269571	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000309185	ENST00000406381	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
intron-3CDS	ENST00000309185	ENST00000406381	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000309185	ENST00000445658	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
intron-3CDS	ENST00000309185	ENST00000445658	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000309185	ENST00000540147	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
intron-3CDS	ENST00000309185	ENST00000540147	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000309185	ENST00000541774	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
intron-3CDS	ENST00000309185	ENST00000541774	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000309185	ENST00000584450	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
intron-3CDS	ENST00000309185	ENST00000584450	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000309185	ENST00000584601	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
intron-3CDS	ENST00000309185	ENST00000584601	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000394204	ENST00000269571	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
intron-3CDS	ENST00000394204	ENST00000269571	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000394204	ENST00000406381	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
intron-3CDS	ENST00000394204	ENST00000406381	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000394204	ENST00000445658	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
intron-3CDS	ENST00000394204	ENST00000445658	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000394204	ENST00000540147	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
intron-3CDS	ENST00000394204	ENST00000540147	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000394204	ENST00000541774	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
intron-3CDS	ENST00000394204	ENST00000541774	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000394204	ENST00000584450	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
intron-3CDS	ENST00000394204	ENST00000584450	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000394204	ENST00000584601	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
intron-3CDS	ENST00000394204	ENST00000584601	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000394209	ENST00000269571	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000394209	ENST00000406381	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000394209	ENST00000445658	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000394209	ENST00000540147	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000394209	ENST00000541774	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000394209	ENST00000584450	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000394209	ENST00000584601	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000394211	ENST00000269571	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000394211	ENST00000406381	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000394211	ENST00000445658	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000394211	ENST00000540147	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000394211	ENST00000541774	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000394211	ENST00000584450	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000394211	ENST00000584601	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000445327	ENST00000269571	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000445327	ENST00000406381	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000445327	ENST00000445658	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000445327	ENST00000540147	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000445327	ENST00000541774	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000445327	ENST00000584450	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000445327	ENST00000584601	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000578702	ENST00000269571	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
intron-3CDS	ENST00000578702	ENST00000269571	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000578702	ENST00000406381	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
intron-3CDS	ENST00000578702	ENST00000406381	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000578702	ENST00000445658	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
intron-3CDS	ENST00000578702	ENST00000445658	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000578702	ENST00000540147	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
intron-3CDS	ENST00000578702	ENST00000540147	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000578702	ENST00000541774	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
intron-3CDS	ENST00000578702	ENST00000541774	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000578702	ENST00000584450	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
intron-3CDS	ENST00000578702	ENST00000584450	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3CDS	ENST00000578702	ENST00000584601	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
intron-3CDS	ENST00000578702	ENST00000584601	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-3UTR	ENST00000309156	ENST00000584888	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-3UTR	ENST00000309185	ENST00000584888	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-3UTR	ENST00000394204	ENST00000584888	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-3UTR	ENST00000394204	ENST00000584888	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-3UTR	ENST00000394209	ENST00000584888	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-3UTR	ENST00000394209	ENST00000584888	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-3UTR	ENST00000394211	ENST00000584888	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-3UTR	ENST00000445327	ENST00000584888	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-3UTR	ENST00000445327	ENST00000584888	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-3UTR	ENST00000578702	ENST00000584888	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-5UTR	ENST00000394204	ENST00000406381	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-5UTR	ENST00000394204	ENST00000578199	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-5UTR	ENST00000394204	ENST00000584601	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-5UTR	ENST00000394209	ENST00000406381	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-5UTR	ENST00000394209	ENST00000578199	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-5UTR	ENST00000394209	ENST00000584601	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-5UTR	ENST00000394211	ENST00000406381	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-5UTR	ENST00000394211	ENST00000578199	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-5UTR	ENST00000394211	ENST00000584601	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-5UTR	ENST00000445327	ENST00000406381	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-5UTR	ENST00000445327	ENST00000578199	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-5UTR	ENST00000445327	ENST00000584601	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-5UTR	ENST00000578702	ENST00000406381	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-5UTR	ENST00000578702	ENST00000578199	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-5UTR	ENST00000578702	ENST00000578199	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
intron-5UTR	ENST00000578702	ENST00000584601	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-5UTR	ENST00000578702	ENST00000584601	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
intron-intron	ENST00000309156	ENST00000269571	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000309156	ENST00000406381	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000309156	ENST00000445658	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000309156	ENST00000540042	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-intron	ENST00000309156	ENST00000540042	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000309156	ENST00000540147	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000309156	ENST00000541774	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000309156	ENST00000578199	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-intron	ENST00000309156	ENST00000578199	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000309156	ENST00000584450	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000309156	ENST00000584601	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000309156	ENST00000584888	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-intron	ENST00000309185	ENST00000269571	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000309185	ENST00000406381	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000309185	ENST00000445658	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000309185	ENST00000540042	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
intron-intron	ENST00000309185	ENST00000540042	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-intron	ENST00000309185	ENST00000540042	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000309185	ENST00000540147	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000309185	ENST00000541774	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000309185	ENST00000578199	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
intron-intron	ENST00000309185	ENST00000578199	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-intron	ENST00000309185	ENST00000578199	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000309185	ENST00000584450	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000309185	ENST00000584601	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000309185	ENST00000584888	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
intron-intron	ENST00000309185	ENST00000584888	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-intron	ENST00000394204	ENST00000269571	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000394204	ENST00000269571	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394204	ENST00000269571	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394204	ENST00000406381	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394204	ENST00000406381	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394204	ENST00000445658	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000394204	ENST00000445658	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394204	ENST00000445658	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394204	ENST00000540042	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000394204	ENST00000540042	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
intron-intron	ENST00000394204	ENST00000540042	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-intron	ENST00000394204	ENST00000540042	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394204	ENST00000540042	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394204	ENST00000540147	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000394204	ENST00000540147	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394204	ENST00000540147	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394204	ENST00000541774	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000394204	ENST00000541774	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394204	ENST00000541774	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394204	ENST00000578199	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
intron-intron	ENST00000394204	ENST00000578199	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-intron	ENST00000394204	ENST00000578199	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394204	ENST00000578199	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394204	ENST00000584450	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000394204	ENST00000584450	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394204	ENST00000584450	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394204	ENST00000584601	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394204	ENST00000584601	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394204	ENST00000584888	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000394204	ENST00000584888	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
intron-intron	ENST00000394204	ENST00000584888	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-intron	ENST00000394209	ENST00000269571	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000394209	ENST00000269571	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394209	ENST00000269571	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394209	ENST00000406381	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394209	ENST00000406381	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394209	ENST00000445658	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000394209	ENST00000445658	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394209	ENST00000445658	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394209	ENST00000540042	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000394209	ENST00000540042	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-intron	ENST00000394209	ENST00000540042	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394209	ENST00000540042	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394209	ENST00000540147	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000394209	ENST00000540147	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394209	ENST00000540147	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394209	ENST00000541774	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000394209	ENST00000541774	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394209	ENST00000541774	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394209	ENST00000578199	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-intron	ENST00000394209	ENST00000578199	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394209	ENST00000578199	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394209	ENST00000584450	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000394209	ENST00000584450	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394209	ENST00000584450	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394209	ENST00000584601	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394209	ENST00000584601	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394209	ENST00000584888	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000394209	ENST00000584888	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-intron	ENST00000394211	ENST00000269571	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000394211	ENST00000269571	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394211	ENST00000406381	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394211	ENST00000445658	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000394211	ENST00000445658	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394211	ENST00000540042	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000394211	ENST00000540042	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-intron	ENST00000394211	ENST00000540042	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394211	ENST00000540147	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000394211	ENST00000540147	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394211	ENST00000541774	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000394211	ENST00000541774	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394211	ENST00000578199	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-intron	ENST00000394211	ENST00000578199	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394211	ENST00000584450	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000394211	ENST00000584450	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394211	ENST00000584601	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000394211	ENST00000584888	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000394211	ENST00000584888	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-intron	ENST00000445327	ENST00000269571	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000445327	ENST00000269571	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000445327	ENST00000269571	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000445327	ENST00000406381	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000445327	ENST00000406381	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000445327	ENST00000445658	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000445327	ENST00000445658	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000445327	ENST00000445658	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000445327	ENST00000540042	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000445327	ENST00000540042	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-intron	ENST00000445327	ENST00000540042	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000445327	ENST00000540042	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000445327	ENST00000540147	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000445327	ENST00000540147	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000445327	ENST00000540147	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000445327	ENST00000541774	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000445327	ENST00000541774	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000445327	ENST00000541774	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000445327	ENST00000578199	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-intron	ENST00000445327	ENST00000578199	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000445327	ENST00000578199	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000445327	ENST00000584450	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000445327	ENST00000584450	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000445327	ENST00000584450	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000445327	ENST00000584601	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000445327	ENST00000584601	GRB7	chr17	37894645	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000445327	ENST00000584888	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000445327	ENST00000584888	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-intron	ENST00000578702	ENST00000269571	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000578702	ENST00000269571	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
intron-intron	ENST00000578702	ENST00000269571	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000578702	ENST00000406381	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
intron-intron	ENST00000578702	ENST00000406381	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000578702	ENST00000445658	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000578702	ENST00000445658	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
intron-intron	ENST00000578702	ENST00000445658	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000578702	ENST00000540042	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000578702	ENST00000540042	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
intron-intron	ENST00000578702	ENST00000540042	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
intron-intron	ENST00000578702	ENST00000540042	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-intron	ENST00000578702	ENST00000540042	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000578702	ENST00000540147	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000578702	ENST00000540147	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
intron-intron	ENST00000578702	ENST00000540147	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000578702	ENST00000541774	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000578702	ENST00000541774	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
intron-intron	ENST00000578702	ENST00000541774	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000578702	ENST00000578199	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
intron-intron	ENST00000578702	ENST00000578199	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+
intron-intron	ENST00000578702	ENST00000578199	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000578702	ENST00000584450	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000578702	ENST00000584450	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
intron-intron	ENST00000578702	ENST00000584450	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000578702	ENST00000584601	GRB7	chr17	37894386	+	ERBB2	chr17	37886276	+
intron-intron	ENST00000578702	ENST00000584888	GRB7	chr17	37894386	+	ERBB2	chr17	37844949	+
intron-intron	ENST00000578702	ENST00000584888	GRB7	chr17	37902253	+	ERBB2	chr17	37883942	+
intron-intron	ENST00000578702	ENST00000584888	GRB7	chr17	37902455	+	ERBB2	chr17	37849514	+
intron-intron	ENST00000578702	ENST00000584888	GRB7	chr17	37897160	+	ERBB2	chr17	37879791	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for GRB7-ERBB2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
GRB7	chr17	37894386	+	ERBB2	chr17	37886275	+	0.99792165	0.002078333
GRB7	chr17	37894645	+	ERBB2	chr17	37886275	+	0.99481755	0.005182483
GRB7	chr17	37902253	+	ERBB2	chr17	37883941	+	0.87347376	0.12652619
GRB7	chr17	37898709	+	ERBB2	chr17	37855789	+	0.3764862	0.6235138
GRB7	chr17	37894386	+	ERBB2	chr17	37844948	+	0.058332726	0.9416672
GRB7	chr17	37902455	+	ERBB2	chr17	37849513	+	0.006241291	0.9937587
GRB7	chr17	37898709	+	ERBB2	chr17	37863242	+	0.000418588	0.9995814
GRB7	chr17	37894386	+	ERBB2	chr17	37886275	+	0.99792165	0.002078333
GRB7	chr17	37894645	+	ERBB2	chr17	37886275	+	0.99481755	0.005182483
GRB7	chr17	37902253	+	ERBB2	chr17	37883941	+	0.87347376	0.12652619
GRB7	chr17	37898709	+	ERBB2	chr17	37855789	+	0.3764862	0.6235138
GRB7	chr17	37894386	+	ERBB2	chr17	37844948	+	0.058332726	0.9416672
GRB7	chr17	37902455	+	ERBB2	chr17	37849513	+	0.006241291	0.9937587
GRB7	chr17	37898709	+	ERBB2	chr17	37863242	+	0.000418588	0.9995814

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GRB7-ERBB2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:37894386/:37844949)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ERBB2 P04626
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269\|PubMed:10358079, ECO:0000269\|PubMed:15380516, ECO:0000269\|PubMed:21555369}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for GRB7-ERBB2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GRB7-ERBB2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for GRB7-ERBB2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for GRB7-ERBB2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source