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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GRB7-PGAP3 (FusionGDB2 ID:34673)

Fusion Gene Summary for GRB7-PGAP3

check button Fusion gene summary
Fusion gene informationFusion gene name: GRB7-PGAP3
Fusion gene ID: 34673
HgeneTgene
Gene symbol

GRB7

PGAP3

Gene ID

2886

93210

Gene namegrowth factor receptor bound protein 7post-GPI attachment to proteins phospholipase 3
Synonyms-AGLA546|CAB2|PERLD1|PP1498|hCOS16
Cytomap

17q12

17q12

Type of geneprotein-codingprotein-coding
Descriptiongrowth factor receptor-bound protein 7B47GRB7 adapter proteinepidermal growth factor receptor GRB-7post-GPI attachment to proteins factor 3COS16 homologgene coamplified with ERBB2 proteinper1-like domain containing 1post-GPI attachment to proteins 3
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000578702, ENST00000309185, 
ENST00000394204, ENST00000309156, 
ENST00000394209, ENST00000394211, 
ENST00000445327, 		ENST00000300658, 
ENST00000378011, ENST00000429199, 
ENST00000579146, 
Fusion gene scores* DoF score23 X 20 X 8=36809 X 8 X 6=432
# samples 4216
** MAII scorelog2(42/3680*10)=-3.13124453327825
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/432*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GRB7 [Title/Abstract] AND PGAP3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGRB7(37899307)-PGAP3(37842272), # samples:3
PGAP3(37844087)-GRB7(37898505), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGRB7

GO:0030335

positive regulation of cell migration

10893408|12021278


check buttonFusion gene breakpoints across GRB7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PGAP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A09I-01AGRB7chr17

37894386

+PGAP3chr17

37830932

-
ChimerDB4BRCATCGA-A8-A09I-01AGRB7chr17

37894645

+PGAP3chr17

37830932

-
ChimerDB4BRCATCGA-A8-A09IGRB7chr17

37894645

+PGAP3chr17

37830932

-
ChimerDB4BRCATCGA-BH-A202-01AGRB7chr17

37898708

+PGAP3chr17

37842271

-
ChimerDB4BRCATCGA-BH-A202-01AGRB7chr17

37898709

+PGAP3chr17

37842272

-
ChimerDB4BRCATCGA-BH-A202-01AGRB7chr17

37898968

+PGAP3chr17

37842271

-
ChimerDB4BRCATCGA-BH-A202-01AGRB7chr17

37898969

+PGAP3chr17

37842272

-
ChimerDB4BRCATCGA-BH-A202-01AGRB7chr17

37899306

+PGAP3chr17

37842271

-
ChimerDB4BRCATCGA-BH-A202-01AGRB7chr17

37899307

-PGAP3chr17

37842272

-
ChimerDB4BRCATCGA-BH-A202-01AGRB7chr17

37899307

+PGAP3chr17

37842272

-
ChimerDB4BRCATCGA-BH-A202GRB7chr17

37898709

+PGAP3chr17

37842272

-
ChimerDB4BRCATCGA-BH-A202GRB7chr17

37898969

+PGAP3chr17

37842272

-
ChimerDB4BRCATCGA-BH-A202GRB7chr17

37899307

+PGAP3chr17

37842272

-
ChimerDB4ESCATCGA-R6-A8W5GRB7chr17

37902455

+PGAP3chr17

37830932

-


Top

Fusion Gene ORF analysis for GRB7-PGAP3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000578702ENST00000300658GRB7chr17

37898708

+PGAP3chr17

37842271

-
3UTR-3CDSENST00000578702ENST00000300658GRB7chr17

37898968

+PGAP3chr17

37842271

-
3UTR-3CDSENST00000578702ENST00000300658GRB7chr17

37898709

+PGAP3chr17

37842272

-
3UTR-3CDSENST00000578702ENST00000300658GRB7chr17

37898969

+PGAP3chr17

37842272

-
3UTR-3CDSENST00000578702ENST00000378011GRB7chr17

37898708

+PGAP3chr17

37842271

-
3UTR-3CDSENST00000578702ENST00000378011GRB7chr17

37898968

+PGAP3chr17

37842271

-
3UTR-3CDSENST00000578702ENST00000378011GRB7chr17

37898709

+PGAP3chr17

37842272

-
3UTR-3CDSENST00000578702ENST00000378011GRB7chr17

37898969

+PGAP3chr17

37842272

-
3UTR-3CDSENST00000578702ENST00000429199GRB7chr17

37898708

+PGAP3chr17

37842271

-
3UTR-3CDSENST00000578702ENST00000429199GRB7chr17

37898968

+PGAP3chr17

37842271

-
3UTR-3CDSENST00000578702ENST00000429199GRB7chr17

37898709

+PGAP3chr17

37842272

-
3UTR-3CDSENST00000578702ENST00000429199GRB7chr17

37898969

+PGAP3chr17

37842272

-
3UTR-3CDSENST00000578702ENST00000579146GRB7chr17

37898708

+PGAP3chr17

37842271

-
3UTR-3CDSENST00000578702ENST00000579146GRB7chr17

37898968

+PGAP3chr17

37842271

-
3UTR-3CDSENST00000578702ENST00000579146GRB7chr17

37898709

+PGAP3chr17

37842272

-
3UTR-3CDSENST00000578702ENST00000579146GRB7chr17

37898969

+PGAP3chr17

37842272

-
3UTR-intronENST00000309185ENST00000300658GRB7chr17

37902455

+PGAP3chr17

37830932

-
3UTR-intronENST00000309185ENST00000378011GRB7chr17

37902455

+PGAP3chr17

37830932

-
3UTR-intronENST00000309185ENST00000429199GRB7chr17

37902455

+PGAP3chr17

37830932

-
3UTR-intronENST00000309185ENST00000579146GRB7chr17

37902455

+PGAP3chr17

37830932

-
3UTR-intronENST00000394204ENST00000300658GRB7chr17

37902455

+PGAP3chr17

37830932

-
3UTR-intronENST00000394204ENST00000378011GRB7chr17

37902455

+PGAP3chr17

37830932

-
3UTR-intronENST00000394204ENST00000429199GRB7chr17

37902455

+PGAP3chr17

37830932

-
3UTR-intronENST00000394204ENST00000579146GRB7chr17

37902455

+PGAP3chr17

37830932

-
3UTR-intronENST00000578702ENST00000300658GRB7chr17

37894645

+PGAP3chr17

37830932

-
3UTR-intronENST00000578702ENST00000378011GRB7chr17

37894645

+PGAP3chr17

37830932

-
3UTR-intronENST00000578702ENST00000429199GRB7chr17

37894645

+PGAP3chr17

37830932

-
3UTR-intronENST00000578702ENST00000579146GRB7chr17

37894645

+PGAP3chr17

37830932

-
5CDS-intronENST00000309156ENST00000300658GRB7chr17

37902455

+PGAP3chr17

37830932

-
5CDS-intronENST00000309156ENST00000378011GRB7chr17

37902455

+PGAP3chr17

37830932

-
5CDS-intronENST00000309156ENST00000429199GRB7chr17

37902455

+PGAP3chr17

37830932

-
5CDS-intronENST00000309156ENST00000579146GRB7chr17

37902455

+PGAP3chr17

37830932

-
5CDS-intronENST00000394209ENST00000300658GRB7chr17

37902455

+PGAP3chr17

37830932

-
5CDS-intronENST00000394209ENST00000378011GRB7chr17

37902455

+PGAP3chr17

37830932

-
5CDS-intronENST00000394209ENST00000429199GRB7chr17

37902455

+PGAP3chr17

37830932

-
5CDS-intronENST00000394209ENST00000579146GRB7chr17

37902455

+PGAP3chr17

37830932

-
5CDS-intronENST00000394211ENST00000300658GRB7chr17

37902455

+PGAP3chr17

37830932

-
5CDS-intronENST00000394211ENST00000378011GRB7chr17

37902455

+PGAP3chr17

37830932

-
5CDS-intronENST00000394211ENST00000429199GRB7chr17

37902455

+PGAP3chr17

37830932

-
5CDS-intronENST00000394211ENST00000579146GRB7chr17

37902455

+PGAP3chr17

37830932

-
5CDS-intronENST00000445327ENST00000300658GRB7chr17

37902455

+PGAP3chr17

37830932

-
5CDS-intronENST00000445327ENST00000378011GRB7chr17

37902455

+PGAP3chr17

37830932

-
5CDS-intronENST00000445327ENST00000429199GRB7chr17

37902455

+PGAP3chr17

37830932

-
5CDS-intronENST00000445327ENST00000579146GRB7chr17

37902455

+PGAP3chr17

37830932

-
5UTR-intronENST00000309156ENST00000300658GRB7chr17

37894386

+PGAP3chr17

37830932

-
5UTR-intronENST00000309156ENST00000378011GRB7chr17

37894386

+PGAP3chr17

37830932

-
5UTR-intronENST00000309156ENST00000429199GRB7chr17

37894386

+PGAP3chr17

37830932

-
5UTR-intronENST00000309156ENST00000579146GRB7chr17

37894386

+PGAP3chr17

37830932

-
5UTR-intronENST00000309185ENST00000300658GRB7chr17

37894386

+PGAP3chr17

37830932

-
5UTR-intronENST00000309185ENST00000378011GRB7chr17

37894386

+PGAP3chr17

37830932

-
5UTR-intronENST00000309185ENST00000429199GRB7chr17

37894386

+PGAP3chr17

37830932

-
5UTR-intronENST00000309185ENST00000579146GRB7chr17

37894386

+PGAP3chr17

37830932

-
5UTR-intronENST00000394211ENST00000300658GRB7chr17

37894645

+PGAP3chr17

37830932

-
5UTR-intronENST00000394211ENST00000378011GRB7chr17

37894645

+PGAP3chr17

37830932

-
5UTR-intronENST00000394211ENST00000429199GRB7chr17

37894645

+PGAP3chr17

37830932

-
5UTR-intronENST00000394211ENST00000579146GRB7chr17

37894645

+PGAP3chr17

37830932

-
Frame-shiftENST00000309156ENST00000300658GRB7chr17

37898708

+PGAP3chr17

37842271

-
Frame-shiftENST00000309156ENST00000300658GRB7chr17

37898968

+PGAP3chr17

37842271

-
Frame-shiftENST00000309156ENST00000300658GRB7chr17

37898709

+PGAP3chr17

37842272

-
Frame-shiftENST00000309156ENST00000300658GRB7chr17

37898969

+PGAP3chr17

37842272

-
Frame-shiftENST00000309156ENST00000378011GRB7chr17

37898708

+PGAP3chr17

37842271

-
Frame-shiftENST00000309156ENST00000378011GRB7chr17

37898968

+PGAP3chr17

37842271

-
Frame-shiftENST00000309156ENST00000378011GRB7chr17

37898709

+PGAP3chr17

37842272

-
Frame-shiftENST00000309156ENST00000378011GRB7chr17

37898969

+PGAP3chr17

37842272

-
Frame-shiftENST00000309156ENST00000429199GRB7chr17

37898708

+PGAP3chr17

37842271

-
Frame-shiftENST00000309156ENST00000429199GRB7chr17

37898968

+PGAP3chr17

37842271

-
Frame-shiftENST00000309156ENST00000429199GRB7chr17

37898709

+PGAP3chr17

37842272

-
Frame-shiftENST00000309156ENST00000429199GRB7chr17

37898969

+PGAP3chr17

37842272

-
Frame-shiftENST00000309156ENST00000579146GRB7chr17

37898708

+PGAP3chr17

37842271

-
Frame-shiftENST00000309156ENST00000579146GRB7chr17

37898968

+PGAP3chr17

37842271

-
Frame-shiftENST00000309156ENST00000579146GRB7chr17

37898709

+PGAP3chr17

37842272

-
Frame-shiftENST00000309156ENST00000579146GRB7chr17

37898969

+PGAP3chr17

37842272

-
Frame-shiftENST00000309185ENST00000300658GRB7chr17

37898708

+PGAP3chr17

37842271

-
Frame-shiftENST00000309185ENST00000300658GRB7chr17

37898968

+PGAP3chr17

37842271

-
Frame-shiftENST00000309185ENST00000300658GRB7chr17

37898709

+PGAP3chr17

37842272

-
Frame-shiftENST00000309185ENST00000300658GRB7chr17

37898969

+PGAP3chr17

37842272

-
Frame-shiftENST00000309185ENST00000378011GRB7chr17

37898708

+PGAP3chr17

37842271

-
Frame-shiftENST00000309185ENST00000378011GRB7chr17

37898968

+PGAP3chr17

37842271

-
Frame-shiftENST00000309185ENST00000378011GRB7chr17

37898709

+PGAP3chr17

37842272

-
Frame-shiftENST00000309185ENST00000378011GRB7chr17

37898969

+PGAP3chr17

37842272

-
Frame-shiftENST00000309185ENST00000429199GRB7chr17

37898708

+PGAP3chr17

37842271

-
Frame-shiftENST00000309185ENST00000429199GRB7chr17

37898968

+PGAP3chr17

37842271

-
Frame-shiftENST00000309185ENST00000429199GRB7chr17

37898709

+PGAP3chr17

37842272

-
Frame-shiftENST00000309185ENST00000429199GRB7chr17

37898969

+PGAP3chr17

37842272

-
Frame-shiftENST00000309185ENST00000579146GRB7chr17

37898708

+PGAP3chr17

37842271

-
Frame-shiftENST00000309185ENST00000579146GRB7chr17

37898968

+PGAP3chr17

37842271

-
Frame-shiftENST00000309185ENST00000579146GRB7chr17

37898709

+PGAP3chr17

37842272

-
Frame-shiftENST00000309185ENST00000579146GRB7chr17

37898969

+PGAP3chr17

37842272

-
Frame-shiftENST00000394204ENST00000300658GRB7chr17

37898708

+PGAP3chr17

37842271

-
Frame-shiftENST00000394204ENST00000300658GRB7chr17

37898968

+PGAP3chr17

37842271

-
Frame-shiftENST00000394204ENST00000300658GRB7chr17

37898709

+PGAP3chr17

37842272

-
Frame-shiftENST00000394204ENST00000300658GRB7chr17

37898969

+PGAP3chr17

37842272

-
Frame-shiftENST00000394204ENST00000378011GRB7chr17

37898708

+PGAP3chr17

37842271

-
Frame-shiftENST00000394204ENST00000378011GRB7chr17

37898968

+PGAP3chr17

37842271

-
Frame-shiftENST00000394204ENST00000378011GRB7chr17

37898709

+PGAP3chr17

37842272

-
Frame-shiftENST00000394204ENST00000378011GRB7chr17

37898969

+PGAP3chr17

37842272

-
Frame-shiftENST00000394204ENST00000429199GRB7chr17

37898708

+PGAP3chr17

37842271

-
Frame-shiftENST00000394204ENST00000429199GRB7chr17

37898968

+PGAP3chr17

37842271

-
Frame-shiftENST00000394204ENST00000429199GRB7chr17

37898709

+PGAP3chr17

37842272

-
Frame-shiftENST00000394204ENST00000429199GRB7chr17

37898969

+PGAP3chr17

37842272

-
Frame-shiftENST00000394204ENST00000579146GRB7chr17

37898708

+PGAP3chr17

37842271

-
Frame-shiftENST00000394204ENST00000579146GRB7chr17

37898968

+PGAP3chr17

37842271

-
Frame-shiftENST00000394204ENST00000579146GRB7chr17

37898709

+PGAP3chr17

37842272

-
Frame-shiftENST00000394204ENST00000579146GRB7chr17

37898969

+PGAP3chr17

37842272

-
Frame-shiftENST00000394209ENST00000300658GRB7chr17

37898708

+PGAP3chr17

37842271

-
Frame-shiftENST00000394209ENST00000300658GRB7chr17

37898968

+PGAP3chr17

37842271

-
Frame-shiftENST00000394209ENST00000300658GRB7chr17

37898709

+PGAP3chr17

37842272

-
Frame-shiftENST00000394209ENST00000300658GRB7chr17

37898969

+PGAP3chr17

37842272

-
Frame-shiftENST00000394209ENST00000378011GRB7chr17

37898708

+PGAP3chr17

37842271

-
Frame-shiftENST00000394209ENST00000378011GRB7chr17

37898968

+PGAP3chr17

37842271

-
Frame-shiftENST00000394209ENST00000378011GRB7chr17

37898709

+PGAP3chr17

37842272

-
Frame-shiftENST00000394209ENST00000378011GRB7chr17

37898969

+PGAP3chr17

37842272

-
Frame-shiftENST00000394209ENST00000429199GRB7chr17

37898708

+PGAP3chr17

37842271

-
Frame-shiftENST00000394209ENST00000429199GRB7chr17

37898968

+PGAP3chr17

37842271

-
Frame-shiftENST00000394209ENST00000429199GRB7chr17

37898709

+PGAP3chr17

37842272

-
Frame-shiftENST00000394209ENST00000429199GRB7chr17

37898969

+PGAP3chr17

37842272

-
Frame-shiftENST00000394209ENST00000579146GRB7chr17

37898708

+PGAP3chr17

37842271

-
Frame-shiftENST00000394209ENST00000579146GRB7chr17

37898968

+PGAP3chr17

37842271

-
Frame-shiftENST00000394209ENST00000579146GRB7chr17

37898709

+PGAP3chr17

37842272

-
Frame-shiftENST00000394209ENST00000579146GRB7chr17

37898969

+PGAP3chr17

37842272

-
Frame-shiftENST00000394211ENST00000300658GRB7chr17

37898708

+PGAP3chr17

37842271

-
Frame-shiftENST00000394211ENST00000300658GRB7chr17

37898968

+PGAP3chr17

37842271

-
Frame-shiftENST00000394211ENST00000300658GRB7chr17

37898709

+PGAP3chr17

37842272

-
Frame-shiftENST00000394211ENST00000300658GRB7chr17

37898969

+PGAP3chr17

37842272

-
Frame-shiftENST00000394211ENST00000378011GRB7chr17

37898708

+PGAP3chr17

37842271

-
Frame-shiftENST00000394211ENST00000378011GRB7chr17

37898968

+PGAP3chr17

37842271

-
Frame-shiftENST00000394211ENST00000378011GRB7chr17

37898709

+PGAP3chr17

37842272

-
Frame-shiftENST00000394211ENST00000378011GRB7chr17

37898969

+PGAP3chr17

37842272

-
Frame-shiftENST00000394211ENST00000429199GRB7chr17

37898708

+PGAP3chr17

37842271

-
Frame-shiftENST00000394211ENST00000429199GRB7chr17

37898968

+PGAP3chr17

37842271

-
Frame-shiftENST00000394211ENST00000429199GRB7chr17

37898709

+PGAP3chr17

37842272

-
Frame-shiftENST00000394211ENST00000429199GRB7chr17

37898969

+PGAP3chr17

37842272

-
Frame-shiftENST00000394211ENST00000579146GRB7chr17

37898708

+PGAP3chr17

37842271

-
Frame-shiftENST00000394211ENST00000579146GRB7chr17

37898968

+PGAP3chr17

37842271

-
Frame-shiftENST00000394211ENST00000579146GRB7chr17

37898709

+PGAP3chr17

37842272

-
Frame-shiftENST00000394211ENST00000579146GRB7chr17

37898969

+PGAP3chr17

37842272

-
Frame-shiftENST00000445327ENST00000300658GRB7chr17

37898708

+PGAP3chr17

37842271

-
Frame-shiftENST00000445327ENST00000300658GRB7chr17

37898968

+PGAP3chr17

37842271

-
Frame-shiftENST00000445327ENST00000300658GRB7chr17

37898709

+PGAP3chr17

37842272

-
Frame-shiftENST00000445327ENST00000300658GRB7chr17

37898969

+PGAP3chr17

37842272

-
Frame-shiftENST00000445327ENST00000378011GRB7chr17

37898708

+PGAP3chr17

37842271

-
Frame-shiftENST00000445327ENST00000378011GRB7chr17

37898968

+PGAP3chr17

37842271

-
Frame-shiftENST00000445327ENST00000378011GRB7chr17

37898709

+PGAP3chr17

37842272

-
Frame-shiftENST00000445327ENST00000378011GRB7chr17

37898969

+PGAP3chr17

37842272

-
Frame-shiftENST00000445327ENST00000429199GRB7chr17

37898708

+PGAP3chr17

37842271

-
Frame-shiftENST00000445327ENST00000429199GRB7chr17

37898968

+PGAP3chr17

37842271

-
Frame-shiftENST00000445327ENST00000429199GRB7chr17

37898709

+PGAP3chr17

37842272

-
Frame-shiftENST00000445327ENST00000429199GRB7chr17

37898969

+PGAP3chr17

37842272

-
Frame-shiftENST00000445327ENST00000579146GRB7chr17

37898708

+PGAP3chr17

37842271

-
Frame-shiftENST00000445327ENST00000579146GRB7chr17

37898968

+PGAP3chr17

37842271

-
Frame-shiftENST00000445327ENST00000579146GRB7chr17

37898709

+PGAP3chr17

37842272

-
Frame-shiftENST00000445327ENST00000579146GRB7chr17

37898969

+PGAP3chr17

37842272

-
In-frameENST00000309156ENST00000300658GRB7chr17

37899306

+PGAP3chr17

37842271

-
In-frameENST00000309156ENST00000300658GRB7chr17

37899307

+PGAP3chr17

37842272

-
In-frameENST00000309156ENST00000378011GRB7chr17

37899306

+PGAP3chr17

37842271

-
In-frameENST00000309156ENST00000378011GRB7chr17

37899307

+PGAP3chr17

37842272

-
In-frameENST00000309156ENST00000429199GRB7chr17

37899306

+PGAP3chr17

37842271

-
In-frameENST00000309156ENST00000429199GRB7chr17

37899307

+PGAP3chr17

37842272

-
In-frameENST00000309156ENST00000579146GRB7chr17

37899306

+PGAP3chr17

37842271

-
In-frameENST00000309156ENST00000579146GRB7chr17

37899307

+PGAP3chr17

37842272

-
In-frameENST00000309185ENST00000300658GRB7chr17

37899306

+PGAP3chr17

37842271

-
In-frameENST00000309185ENST00000300658GRB7chr17

37899307

+PGAP3chr17

37842272

-
In-frameENST00000309185ENST00000378011GRB7chr17

37899306

+PGAP3chr17

37842271

-
In-frameENST00000309185ENST00000378011GRB7chr17

37899307

+PGAP3chr17

37842272

-
In-frameENST00000309185ENST00000429199GRB7chr17

37899306

+PGAP3chr17

37842271

-
In-frameENST00000309185ENST00000429199GRB7chr17

37899307

+PGAP3chr17

37842272

-
In-frameENST00000309185ENST00000579146GRB7chr17

37899306

+PGAP3chr17

37842271

-
In-frameENST00000309185ENST00000579146GRB7chr17

37899307

+PGAP3chr17

37842272

-
In-frameENST00000394204ENST00000300658GRB7chr17

37899306

+PGAP3chr17

37842271

-
In-frameENST00000394204ENST00000300658GRB7chr17

37899307

+PGAP3chr17

37842272

-
In-frameENST00000394204ENST00000378011GRB7chr17

37899306

+PGAP3chr17

37842271

-
In-frameENST00000394204ENST00000378011GRB7chr17

37899307

+PGAP3chr17

37842272

-
In-frameENST00000394204ENST00000429199GRB7chr17

37899306

+PGAP3chr17

37842271

-
In-frameENST00000394204ENST00000429199GRB7chr17

37899307

+PGAP3chr17

37842272

-
In-frameENST00000394204ENST00000579146GRB7chr17

37899306

+PGAP3chr17

37842271

-
In-frameENST00000394204ENST00000579146GRB7chr17

37899307

+PGAP3chr17

37842272

-
In-frameENST00000394209ENST00000300658GRB7chr17

37899306

+PGAP3chr17

37842271

-
In-frameENST00000394209ENST00000300658GRB7chr17

37899307

+PGAP3chr17

37842272

-
In-frameENST00000394209ENST00000378011GRB7chr17

37899306

+PGAP3chr17

37842271

-
In-frameENST00000394209ENST00000378011GRB7chr17

37899307

+PGAP3chr17

37842272

-
In-frameENST00000394209ENST00000429199GRB7chr17

37899306

+PGAP3chr17

37842271

-
In-frameENST00000394209ENST00000429199GRB7chr17

37899307

+PGAP3chr17

37842272

-
In-frameENST00000394209ENST00000579146GRB7chr17

37899306

+PGAP3chr17

37842271

-
In-frameENST00000394209ENST00000579146GRB7chr17

37899307

+PGAP3chr17

37842272

-
In-frameENST00000394211ENST00000300658GRB7chr17

37899306

+PGAP3chr17

37842271

-
In-frameENST00000394211ENST00000300658GRB7chr17

37899307

+PGAP3chr17

37842272

-
In-frameENST00000394211ENST00000378011GRB7chr17

37899306

+PGAP3chr17

37842271

-
In-frameENST00000394211ENST00000378011GRB7chr17

37899307

+PGAP3chr17

37842272

-
In-frameENST00000394211ENST00000429199GRB7chr17

37899306

+PGAP3chr17

37842271

-
In-frameENST00000394211ENST00000429199GRB7chr17

37899307

+PGAP3chr17

37842272

-
In-frameENST00000394211ENST00000579146GRB7chr17

37899306

+PGAP3chr17

37842271

-
In-frameENST00000394211ENST00000579146GRB7chr17

37899307

+PGAP3chr17

37842272

-
In-frameENST00000445327ENST00000300658GRB7chr17

37899306

+PGAP3chr17

37842271

-
In-frameENST00000445327ENST00000300658GRB7chr17

37899307

+PGAP3chr17

37842272

-
In-frameENST00000445327ENST00000378011GRB7chr17

37899306

+PGAP3chr17

37842271

-
In-frameENST00000445327ENST00000378011GRB7chr17

37899307

+PGAP3chr17

37842272

-
In-frameENST00000445327ENST00000429199GRB7chr17

37899306

+PGAP3chr17

37842271

-
In-frameENST00000445327ENST00000429199GRB7chr17

37899307

+PGAP3chr17

37842272

-
In-frameENST00000445327ENST00000579146GRB7chr17

37899306

+PGAP3chr17

37842271

-
In-frameENST00000445327ENST00000579146GRB7chr17

37899307

+PGAP3chr17

37842272

-
intron-3CDSENST00000578702ENST00000300658GRB7chr17

37899306

+PGAP3chr17

37842271

-
intron-3CDSENST00000578702ENST00000300658GRB7chr17

37899307

+PGAP3chr17

37842272

-
intron-3CDSENST00000578702ENST00000378011GRB7chr17

37899306

+PGAP3chr17

37842271

-
intron-3CDSENST00000578702ENST00000378011GRB7chr17

37899307

+PGAP3chr17

37842272

-
intron-3CDSENST00000578702ENST00000429199GRB7chr17

37899306

+PGAP3chr17

37842271

-
intron-3CDSENST00000578702ENST00000429199GRB7chr17

37899307

+PGAP3chr17

37842272

-
intron-3CDSENST00000578702ENST00000579146GRB7chr17

37899306

+PGAP3chr17

37842271

-
intron-3CDSENST00000578702ENST00000579146GRB7chr17

37899307

+PGAP3chr17

37842272

-
intron-intronENST00000309156ENST00000300658GRB7chr17

37894645

+PGAP3chr17

37830932

-
intron-intronENST00000309156ENST00000378011GRB7chr17

37894645

+PGAP3chr17

37830932

-
intron-intronENST00000309156ENST00000429199GRB7chr17

37894645

+PGAP3chr17

37830932

-
intron-intronENST00000309156ENST00000579146GRB7chr17

37894645

+PGAP3chr17

37830932

-
intron-intronENST00000309185ENST00000300658GRB7chr17

37894645

+PGAP3chr17

37830932

-
intron-intronENST00000309185ENST00000378011GRB7chr17

37894645

+PGAP3chr17

37830932

-
intron-intronENST00000309185ENST00000429199GRB7chr17

37894645

+PGAP3chr17

37830932

-
intron-intronENST00000309185ENST00000579146GRB7chr17

37894645

+PGAP3chr17

37830932

-
intron-intronENST00000394204ENST00000300658GRB7chr17

37894386

+PGAP3chr17

37830932

-
intron-intronENST00000394204ENST00000300658GRB7chr17

37894645

+PGAP3chr17

37830932

-
intron-intronENST00000394204ENST00000378011GRB7chr17

37894386

+PGAP3chr17

37830932

-
intron-intronENST00000394204ENST00000378011GRB7chr17

37894645

+PGAP3chr17

37830932

-
intron-intronENST00000394204ENST00000429199GRB7chr17

37894386

+PGAP3chr17

37830932

-
intron-intronENST00000394204ENST00000429199GRB7chr17

37894645

+PGAP3chr17

37830932

-
intron-intronENST00000394204ENST00000579146GRB7chr17

37894386

+PGAP3chr17

37830932

-
intron-intronENST00000394204ENST00000579146GRB7chr17

37894645

+PGAP3chr17

37830932

-
intron-intronENST00000394209ENST00000300658GRB7chr17

37894386

+PGAP3chr17

37830932

-
intron-intronENST00000394209ENST00000300658GRB7chr17

37894645

+PGAP3chr17

37830932

-
intron-intronENST00000394209ENST00000378011GRB7chr17

37894386

+PGAP3chr17

37830932

-
intron-intronENST00000394209ENST00000378011GRB7chr17

37894645

+PGAP3chr17

37830932

-
intron-intronENST00000394209ENST00000429199GRB7chr17

37894386

+PGAP3chr17

37830932

-
intron-intronENST00000394209ENST00000429199GRB7chr17

37894645

+PGAP3chr17

37830932

-
intron-intronENST00000394209ENST00000579146GRB7chr17

37894386

+PGAP3chr17

37830932

-
intron-intronENST00000394209ENST00000579146GRB7chr17

37894645

+PGAP3chr17

37830932

-
intron-intronENST00000394211ENST00000300658GRB7chr17

37894386

+PGAP3chr17

37830932

-
intron-intronENST00000394211ENST00000378011GRB7chr17

37894386

+PGAP3chr17

37830932

-
intron-intronENST00000394211ENST00000429199GRB7chr17

37894386

+PGAP3chr17

37830932

-
intron-intronENST00000394211ENST00000579146GRB7chr17

37894386

+PGAP3chr17

37830932

-
intron-intronENST00000445327ENST00000300658GRB7chr17

37894386

+PGAP3chr17

37830932

-
intron-intronENST00000445327ENST00000300658GRB7chr17

37894645

+PGAP3chr17

37830932

-
intron-intronENST00000445327ENST00000378011GRB7chr17

37894386

+PGAP3chr17

37830932

-
intron-intronENST00000445327ENST00000378011GRB7chr17

37894645

+PGAP3chr17

37830932

-
intron-intronENST00000445327ENST00000429199GRB7chr17

37894386

+PGAP3chr17

37830932

-
intron-intronENST00000445327ENST00000429199GRB7chr17

37894645

+PGAP3chr17

37830932

-
intron-intronENST00000445327ENST00000579146GRB7chr17

37894386

+PGAP3chr17

37830932

-
intron-intronENST00000445327ENST00000579146GRB7chr17

37894645

+PGAP3chr17

37830932

-
intron-intronENST00000578702ENST00000300658GRB7chr17

37894386

+PGAP3chr17

37830932

-
intron-intronENST00000578702ENST00000300658GRB7chr17

37902455

+PGAP3chr17

37830932

-
intron-intronENST00000578702ENST00000378011GRB7chr17

37894386

+PGAP3chr17

37830932

-
intron-intronENST00000578702ENST00000378011GRB7chr17

37902455

+PGAP3chr17

37830932

-
intron-intronENST00000578702ENST00000429199GRB7chr17

37894386

+PGAP3chr17

37830932

-
intron-intronENST00000578702ENST00000429199GRB7chr17

37902455

+PGAP3chr17

37830932

-
intron-intronENST00000578702ENST00000579146GRB7chr17

37894386

+PGAP3chr17

37830932

-
intron-intronENST00000578702ENST00000579146GRB7chr17

37902455

+PGAP3chr17

37830932

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for GRB7-PGAP3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for GRB7-PGAP3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:37899307/chr17:37842272)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePGAP3chr17:37899306chr17:37842271ENST0000030065808120_13560321.0Topological domainCytoplasmic
TgenePGAP3chr17:37899306chr17:37842271ENST0000030065808157_16960321.0Topological domainLumenal
TgenePGAP3chr17:37899306chr17:37842271ENST0000030065808191_19360321.0Topological domainCytoplasmic
TgenePGAP3chr17:37899306chr17:37842271ENST0000030065808215_22460321.0Topological domainLumenal
TgenePGAP3chr17:37899306chr17:37842271ENST0000030065808246_25760321.0Topological domainCytoplasmic
TgenePGAP3chr17:37899306chr17:37842271ENST0000030065808279_27960321.0Topological domainLumenal
TgenePGAP3chr17:37899306chr17:37842271ENST0000030065808300_32060321.0Topological domainCytoplasmic
TgenePGAP3chr17:37899306chr17:37842271ENST0000037801107120_13560270.0Topological domainCytoplasmic
TgenePGAP3chr17:37899306chr17:37842271ENST0000037801107157_16960270.0Topological domainLumenal
TgenePGAP3chr17:37899306chr17:37842271ENST0000037801107191_19360270.0Topological domainCytoplasmic
TgenePGAP3chr17:37899306chr17:37842271ENST0000037801107215_22460270.0Topological domainLumenal
TgenePGAP3chr17:37899306chr17:37842271ENST0000037801107246_25760270.0Topological domainCytoplasmic
TgenePGAP3chr17:37899306chr17:37842271ENST0000037801107279_27960270.0Topological domainLumenal
TgenePGAP3chr17:37899306chr17:37842271ENST0000037801107300_32060270.0Topological domainCytoplasmic
TgenePGAP3chr17:37899307chr17:37842272ENST0000030065808120_13560321.0Topological domainCytoplasmic
TgenePGAP3chr17:37899307chr17:37842272ENST0000030065808157_16960321.0Topological domainLumenal
TgenePGAP3chr17:37899307chr17:37842272ENST0000030065808191_19360321.0Topological domainCytoplasmic
TgenePGAP3chr17:37899307chr17:37842272ENST0000030065808215_22460321.0Topological domainLumenal
TgenePGAP3chr17:37899307chr17:37842272ENST0000030065808246_25760321.0Topological domainCytoplasmic
TgenePGAP3chr17:37899307chr17:37842272ENST0000030065808279_27960321.0Topological domainLumenal
TgenePGAP3chr17:37899307chr17:37842272ENST0000030065808300_32060321.0Topological domainCytoplasmic
TgenePGAP3chr17:37899307chr17:37842272ENST0000037801107120_13560270.0Topological domainCytoplasmic
TgenePGAP3chr17:37899307chr17:37842272ENST0000037801107157_16960270.0Topological domainLumenal
TgenePGAP3chr17:37899307chr17:37842272ENST0000037801107191_19360270.0Topological domainCytoplasmic
TgenePGAP3chr17:37899307chr17:37842272ENST0000037801107215_22460270.0Topological domainLumenal
TgenePGAP3chr17:37899307chr17:37842272ENST0000037801107246_25760270.0Topological domainCytoplasmic
TgenePGAP3chr17:37899307chr17:37842272ENST0000037801107279_27960270.0Topological domainLumenal
TgenePGAP3chr17:37899307chr17:37842272ENST0000037801107300_32060270.0Topological domainCytoplasmic
TgenePGAP3chr17:37899306chr17:37842271ENST0000030065808136_15660321.0TransmembraneHelical
TgenePGAP3chr17:37899306chr17:37842271ENST0000030065808170_19060321.0TransmembraneHelical
TgenePGAP3chr17:37899306chr17:37842271ENST0000030065808194_21460321.0TransmembraneHelical
TgenePGAP3chr17:37899306chr17:37842271ENST0000030065808225_24560321.0TransmembraneHelical
TgenePGAP3chr17:37899306chr17:37842271ENST0000030065808258_27860321.0TransmembraneHelical
TgenePGAP3chr17:37899306chr17:37842271ENST0000030065808280_29960321.0TransmembraneHelical
TgenePGAP3chr17:37899306chr17:37842271ENST000003006580899_11960321.0TransmembraneHelical
TgenePGAP3chr17:37899306chr17:37842271ENST0000037801107136_15660270.0TransmembraneHelical
TgenePGAP3chr17:37899306chr17:37842271ENST0000037801107170_19060270.0TransmembraneHelical
TgenePGAP3chr17:37899306chr17:37842271ENST0000037801107194_21460270.0TransmembraneHelical
TgenePGAP3chr17:37899306chr17:37842271ENST0000037801107225_24560270.0TransmembraneHelical
TgenePGAP3chr17:37899306chr17:37842271ENST0000037801107258_27860270.0TransmembraneHelical
TgenePGAP3chr17:37899306chr17:37842271ENST0000037801107280_29960270.0TransmembraneHelical
TgenePGAP3chr17:37899306chr17:37842271ENST000003780110799_11960270.0TransmembraneHelical
TgenePGAP3chr17:37899307chr17:37842272ENST0000030065808136_15660321.0TransmembraneHelical
TgenePGAP3chr17:37899307chr17:37842272ENST0000030065808170_19060321.0TransmembraneHelical
TgenePGAP3chr17:37899307chr17:37842272ENST0000030065808194_21460321.0TransmembraneHelical
TgenePGAP3chr17:37899307chr17:37842272ENST0000030065808225_24560321.0TransmembraneHelical
TgenePGAP3chr17:37899307chr17:37842272ENST0000030065808258_27860321.0TransmembraneHelical
TgenePGAP3chr17:37899307chr17:37842272ENST0000030065808280_29960321.0TransmembraneHelical
TgenePGAP3chr17:37899307chr17:37842272ENST000003006580899_11960321.0TransmembraneHelical
TgenePGAP3chr17:37899307chr17:37842272ENST0000037801107136_15660270.0TransmembraneHelical
TgenePGAP3chr17:37899307chr17:37842272ENST0000037801107170_19060270.0TransmembraneHelical
TgenePGAP3chr17:37899307chr17:37842272ENST0000037801107194_21460270.0TransmembraneHelical
TgenePGAP3chr17:37899307chr17:37842272ENST0000037801107225_24560270.0TransmembraneHelical
TgenePGAP3chr17:37899307chr17:37842272ENST0000037801107258_27860270.0TransmembraneHelical
TgenePGAP3chr17:37899307chr17:37842272ENST0000037801107280_29960270.0TransmembraneHelical
TgenePGAP3chr17:37899307chr17:37842272ENST000003780110799_11960270.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGRB7chr17:37899306chr17:37842271ENST00000309156+415100_186154533.0DomainRas-associating
HgeneGRB7chr17:37899306chr17:37842271ENST00000309156+415229_338154533.0DomainPH
HgeneGRB7chr17:37899306chr17:37842271ENST00000309156+415431_527154533.0DomainSH2
HgeneGRB7chr17:37899306chr17:37842271ENST00000309185+414100_186154558.6666666666666DomainRas-associating
HgeneGRB7chr17:37899306chr17:37842271ENST00000309185+414229_338154558.6666666666666DomainPH
HgeneGRB7chr17:37899306chr17:37842271ENST00000309185+414431_527154558.6666666666666DomainSH2
HgeneGRB7chr17:37899306chr17:37842271ENST00000394204+313100_186154464.0DomainRas-associating
HgeneGRB7chr17:37899306chr17:37842271ENST00000394204+313229_338154464.0DomainPH
HgeneGRB7chr17:37899306chr17:37842271ENST00000394204+313431_527154464.0DomainSH2
HgeneGRB7chr17:37899306chr17:37842271ENST00000394209+415100_186154533.0DomainRas-associating
HgeneGRB7chr17:37899306chr17:37842271ENST00000394209+415229_338154533.0DomainPH
HgeneGRB7chr17:37899306chr17:37842271ENST00000394209+415431_527154533.0DomainSH2
HgeneGRB7chr17:37899306chr17:37842271ENST00000394211+415100_186154533.0DomainRas-associating
HgeneGRB7chr17:37899306chr17:37842271ENST00000394211+415229_338154533.0DomainPH
HgeneGRB7chr17:37899306chr17:37842271ENST00000394211+415431_527154533.0DomainSH2
HgeneGRB7chr17:37899306chr17:37842271ENST00000445327+415100_186177556.0DomainRas-associating
HgeneGRB7chr17:37899306chr17:37842271ENST00000445327+415229_338177556.0DomainPH
HgeneGRB7chr17:37899306chr17:37842271ENST00000445327+415431_527177556.0DomainSH2
HgeneGRB7chr17:37899307chr17:37842272ENST00000309156+415100_186154533.0DomainRas-associating
HgeneGRB7chr17:37899307chr17:37842272ENST00000309156+415229_338154533.0DomainPH
HgeneGRB7chr17:37899307chr17:37842272ENST00000309156+415431_527154533.0DomainSH2
HgeneGRB7chr17:37899307chr17:37842272ENST00000309185+414100_186154558.6666666666666DomainRas-associating
HgeneGRB7chr17:37899307chr17:37842272ENST00000309185+414229_338154558.6666666666666DomainPH
HgeneGRB7chr17:37899307chr17:37842272ENST00000309185+414431_527154558.6666666666666DomainSH2
HgeneGRB7chr17:37899307chr17:37842272ENST00000394204+313100_186154464.0DomainRas-associating
HgeneGRB7chr17:37899307chr17:37842272ENST00000394204+313229_338154464.0DomainPH
HgeneGRB7chr17:37899307chr17:37842272ENST00000394204+313431_527154464.0DomainSH2
HgeneGRB7chr17:37899307chr17:37842272ENST00000394209+415100_186154533.0DomainRas-associating
HgeneGRB7chr17:37899307chr17:37842272ENST00000394209+415229_338154533.0DomainPH
HgeneGRB7chr17:37899307chr17:37842272ENST00000394209+415431_527154533.0DomainSH2
HgeneGRB7chr17:37899307chr17:37842272ENST00000394211+415100_186154533.0DomainRas-associating
HgeneGRB7chr17:37899307chr17:37842272ENST00000394211+415229_338154533.0DomainPH
HgeneGRB7chr17:37899307chr17:37842272ENST00000394211+415431_527154533.0DomainSH2
HgeneGRB7chr17:37899307chr17:37842272ENST00000445327+415100_186177556.0DomainRas-associating
HgeneGRB7chr17:37899307chr17:37842272ENST00000445327+415229_338177556.0DomainPH
HgeneGRB7chr17:37899307chr17:37842272ENST00000445327+415431_527177556.0DomainSH2
TgenePGAP3chr17:37899306chr17:37842271ENST000003006580821_9860321.0Topological domainLumenal
TgenePGAP3chr17:37899306chr17:37842271ENST000003780110721_9860270.0Topological domainLumenal
TgenePGAP3chr17:37899307chr17:37842272ENST000003006580821_9860321.0Topological domainLumenal
TgenePGAP3chr17:37899307chr17:37842272ENST000003780110721_9860270.0Topological domainLumenal


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Fusion Gene Sequence for GRB7-PGAP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GRB7-PGAP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GRB7-PGAP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GRB7-PGAP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource