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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GRB7-PIP4K2B (FusionGDB2 ID:34674)

Fusion Gene Summary for GRB7-PIP4K2B

Fusion gene summary

Fusion gene information	Fusion gene name: GRB7-PIP4K2B
	Fusion gene ID: 34674
		Hgene	Tgene
	Gene symbol	GRB7	PIP4K2B
	Gene ID	2886	8396
	Gene name	growth factor receptor bound protein 7	phosphatidylinositol-5-phosphate 4-kinase type 2 beta
	Synonyms	-	PI5P4KB\|PIP5K2B\|PIP5KIIB\|PIP5KIIbeta\|PIP5P4KB
	Cytomap	17q12	17q12
	Type of gene	protein-coding	protein-coding
	Description	growth factor receptor-bound protein 7B47GRB7 adapter proteinepidermal growth factor receptor GRB-7	phosphatidylinositol 5-phosphate 4-kinase type-2 beta1-phosphatidylinositol 5-phosphate 4-kinase 2-beta1-phosphatidylinositol-4-phosphate kinasePI(5)P 4-kinase type II betaPIP4KII-betaPTDINS(4)P-5-kinasediphosphoinositide kinase 2-betaphosphatidyli
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000578702, ENST00000309156, ENST00000309185, ENST00000394204, ENST00000394209, ENST00000394211, ENST00000445327,	ENST00000269554, ENST00000311500,
Fusion gene scores	* DoF score	23 X 20 X 8=3680	15 X 14 X 6=1260
	# samples	42	20
	** MAII score	log2(42/3680*10)=-3.13124453327825 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(20/1260*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GRB7 [Title/Abstract] AND PIP4K2B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GRB7(37898969)-PIP4K2B(36927525), # samples:4
Anticipated loss of major functional domain due to fusion event.	GRB7-PIP4K2B seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. GRB7-PIP4K2B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. GRB7-PIP4K2B seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GRB7	GO:0030335	positive regulation of cell migration	10893408\|12021278

Fusion gene breakpoints across GRB7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PIP4K2B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-L5-A88V-01A	GRB7	chr17	37898969	+	PIP4K2B	chr17	36927525	-
ChimerDB4	ESCA	TCGA-L5-A88V	GRB7	chr17	37894386	+	PIP4K2B	chr17	36927525	-
ChimerDB4	ESCA	TCGA-L5-A88V	GRB7	chr17	37894645	+	PIP4K2B	chr17	36927525	-
ChimerDB4	ESCA	TCGA-L5-A88V	GRB7	chr17	37898709	+	PIP4K2B	chr17	36927525	-
ChimerDB4	ESCA	TCGA-L5-A88V	GRB7	chr17	37898969	+	PIP4K2B	chr17	36927525	-
ChimerDB4	ESCA	TCGA-L5-A88V	GRB7	chr17	37899307	+	PIP4K2B	chr17	36927525	-

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Fusion Gene ORF analysis for GRB7-PIP4K2B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000578702	ENST00000269554	GRB7	chr17	37898969	+	PIP4K2B	chr17	36927525	-
3UTR-3CDS	ENST00000578702	ENST00000269554	GRB7	chr17	37894645	+	PIP4K2B	chr17	36927525	-
3UTR-3CDS	ENST00000578702	ENST00000269554	GRB7	chr17	37898709	+	PIP4K2B	chr17	36927525	-
3UTR-intron	ENST00000578702	ENST00000311500	GRB7	chr17	37898969	+	PIP4K2B	chr17	36927525	-
3UTR-intron	ENST00000578702	ENST00000311500	GRB7	chr17	37894645	+	PIP4K2B	chr17	36927525	-
3UTR-intron	ENST00000578702	ENST00000311500	GRB7	chr17	37898709	+	PIP4K2B	chr17	36927525	-
5CDS-intron	ENST00000309156	ENST00000311500	GRB7	chr17	37898969	+	PIP4K2B	chr17	36927525	-
5CDS-intron	ENST00000309156	ENST00000311500	GRB7	chr17	37898709	+	PIP4K2B	chr17	36927525	-
5CDS-intron	ENST00000309156	ENST00000311500	GRB7	chr17	37899307	+	PIP4K2B	chr17	36927525	-
5CDS-intron	ENST00000309185	ENST00000311500	GRB7	chr17	37898969	+	PIP4K2B	chr17	36927525	-
5CDS-intron	ENST00000309185	ENST00000311500	GRB7	chr17	37898709	+	PIP4K2B	chr17	36927525	-
5CDS-intron	ENST00000309185	ENST00000311500	GRB7	chr17	37899307	+	PIP4K2B	chr17	36927525	-
5CDS-intron	ENST00000394204	ENST00000311500	GRB7	chr17	37898969	+	PIP4K2B	chr17	36927525	-
5CDS-intron	ENST00000394204	ENST00000311500	GRB7	chr17	37898709	+	PIP4K2B	chr17	36927525	-
5CDS-intron	ENST00000394204	ENST00000311500	GRB7	chr17	37899307	+	PIP4K2B	chr17	36927525	-
5CDS-intron	ENST00000394209	ENST00000311500	GRB7	chr17	37898969	+	PIP4K2B	chr17	36927525	-
5CDS-intron	ENST00000394209	ENST00000311500	GRB7	chr17	37898709	+	PIP4K2B	chr17	36927525	-
5CDS-intron	ENST00000394209	ENST00000311500	GRB7	chr17	37899307	+	PIP4K2B	chr17	36927525	-
5CDS-intron	ENST00000394211	ENST00000311500	GRB7	chr17	37898969	+	PIP4K2B	chr17	36927525	-
5CDS-intron	ENST00000394211	ENST00000311500	GRB7	chr17	37898709	+	PIP4K2B	chr17	36927525	-
5CDS-intron	ENST00000394211	ENST00000311500	GRB7	chr17	37899307	+	PIP4K2B	chr17	36927525	-
5CDS-intron	ENST00000445327	ENST00000311500	GRB7	chr17	37898969	+	PIP4K2B	chr17	36927525	-
5CDS-intron	ENST00000445327	ENST00000311500	GRB7	chr17	37898709	+	PIP4K2B	chr17	36927525	-
5CDS-intron	ENST00000445327	ENST00000311500	GRB7	chr17	37899307	+	PIP4K2B	chr17	36927525	-
5UTR-3CDS	ENST00000309156	ENST00000269554	GRB7	chr17	37894386	+	PIP4K2B	chr17	36927525	-
5UTR-3CDS	ENST00000309185	ENST00000269554	GRB7	chr17	37894386	+	PIP4K2B	chr17	36927525	-
5UTR-3CDS	ENST00000394211	ENST00000269554	GRB7	chr17	37894645	+	PIP4K2B	chr17	36927525	-
5UTR-intron	ENST00000309156	ENST00000311500	GRB7	chr17	37894386	+	PIP4K2B	chr17	36927525	-
5UTR-intron	ENST00000309185	ENST00000311500	GRB7	chr17	37894386	+	PIP4K2B	chr17	36927525	-
5UTR-intron	ENST00000394211	ENST00000311500	GRB7	chr17	37894645	+	PIP4K2B	chr17	36927525	-
Frame-shift	ENST00000309156	ENST00000269554	GRB7	chr17	37898709	+	PIP4K2B	chr17	36927525	-
Frame-shift	ENST00000309156	ENST00000269554	GRB7	chr17	37899307	+	PIP4K2B	chr17	36927525	-
Frame-shift	ENST00000309185	ENST00000269554	GRB7	chr17	37898709	+	PIP4K2B	chr17	36927525	-
Frame-shift	ENST00000309185	ENST00000269554	GRB7	chr17	37899307	+	PIP4K2B	chr17	36927525	-
Frame-shift	ENST00000394204	ENST00000269554	GRB7	chr17	37898709	+	PIP4K2B	chr17	36927525	-
Frame-shift	ENST00000394204	ENST00000269554	GRB7	chr17	37899307	+	PIP4K2B	chr17	36927525	-
Frame-shift	ENST00000394209	ENST00000269554	GRB7	chr17	37898709	+	PIP4K2B	chr17	36927525	-
Frame-shift	ENST00000394209	ENST00000269554	GRB7	chr17	37899307	+	PIP4K2B	chr17	36927525	-
Frame-shift	ENST00000394211	ENST00000269554	GRB7	chr17	37898709	+	PIP4K2B	chr17	36927525	-
Frame-shift	ENST00000394211	ENST00000269554	GRB7	chr17	37899307	+	PIP4K2B	chr17	36927525	-
Frame-shift	ENST00000445327	ENST00000269554	GRB7	chr17	37898709	+	PIP4K2B	chr17	36927525	-
Frame-shift	ENST00000445327	ENST00000269554	GRB7	chr17	37899307	+	PIP4K2B	chr17	36927525	-
In-frame	ENST00000309156	ENST00000269554	GRB7	chr17	37898969	+	PIP4K2B	chr17	36927525	-
In-frame	ENST00000309185	ENST00000269554	GRB7	chr17	37898969	+	PIP4K2B	chr17	36927525	-
In-frame	ENST00000394204	ENST00000269554	GRB7	chr17	37898969	+	PIP4K2B	chr17	36927525	-
In-frame	ENST00000394209	ENST00000269554	GRB7	chr17	37898969	+	PIP4K2B	chr17	36927525	-
In-frame	ENST00000394211	ENST00000269554	GRB7	chr17	37898969	+	PIP4K2B	chr17	36927525	-
In-frame	ENST00000445327	ENST00000269554	GRB7	chr17	37898969	+	PIP4K2B	chr17	36927525	-
intron-3CDS	ENST00000309156	ENST00000269554	GRB7	chr17	37894645	+	PIP4K2B	chr17	36927525	-
intron-3CDS	ENST00000309185	ENST00000269554	GRB7	chr17	37894645	+	PIP4K2B	chr17	36927525	-
intron-3CDS	ENST00000394204	ENST00000269554	GRB7	chr17	37894386	+	PIP4K2B	chr17	36927525	-
intron-3CDS	ENST00000394204	ENST00000269554	GRB7	chr17	37894645	+	PIP4K2B	chr17	36927525	-
intron-3CDS	ENST00000394209	ENST00000269554	GRB7	chr17	37894386	+	PIP4K2B	chr17	36927525	-
intron-3CDS	ENST00000394209	ENST00000269554	GRB7	chr17	37894645	+	PIP4K2B	chr17	36927525	-
intron-3CDS	ENST00000394211	ENST00000269554	GRB7	chr17	37894386	+	PIP4K2B	chr17	36927525	-
intron-3CDS	ENST00000445327	ENST00000269554	GRB7	chr17	37894386	+	PIP4K2B	chr17	36927525	-
intron-3CDS	ENST00000445327	ENST00000269554	GRB7	chr17	37894645	+	PIP4K2B	chr17	36927525	-
intron-3CDS	ENST00000578702	ENST00000269554	GRB7	chr17	37894386	+	PIP4K2B	chr17	36927525	-
intron-3CDS	ENST00000578702	ENST00000269554	GRB7	chr17	37899307	+	PIP4K2B	chr17	36927525	-
intron-intron	ENST00000309156	ENST00000311500	GRB7	chr17	37894645	+	PIP4K2B	chr17	36927525	-
intron-intron	ENST00000309185	ENST00000311500	GRB7	chr17	37894645	+	PIP4K2B	chr17	36927525	-
intron-intron	ENST00000394204	ENST00000311500	GRB7	chr17	37894386	+	PIP4K2B	chr17	36927525	-
intron-intron	ENST00000394204	ENST00000311500	GRB7	chr17	37894645	+	PIP4K2B	chr17	36927525	-
intron-intron	ENST00000394209	ENST00000311500	GRB7	chr17	37894386	+	PIP4K2B	chr17	36927525	-
intron-intron	ENST00000394209	ENST00000311500	GRB7	chr17	37894645	+	PIP4K2B	chr17	36927525	-
intron-intron	ENST00000394211	ENST00000311500	GRB7	chr17	37894386	+	PIP4K2B	chr17	36927525	-
intron-intron	ENST00000445327	ENST00000311500	GRB7	chr17	37894386	+	PIP4K2B	chr17	36927525	-
intron-intron	ENST00000445327	ENST00000311500	GRB7	chr17	37894645	+	PIP4K2B	chr17	36927525	-
intron-intron	ENST00000578702	ENST00000311500	GRB7	chr17	37894386	+	PIP4K2B	chr17	36927525	-
intron-intron	ENST00000578702	ENST00000311500	GRB7	chr17	37899307	+	PIP4K2B	chr17	36927525	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000309156	GRB7	chr17	37898969	+	ENST00000269554	PIP4K2B	chr17	36927525	-	5009	563	257	1006	249
ENST00000309185	GRB7	chr17	37898969	+	ENST00000269554	PIP4K2B	chr17	36927525	-	5002	556	250	999	249
ENST00000394211	GRB7	chr17	37898969	+	ENST00000269554	PIP4K2B	chr17	36927525	-	4858	412	106	855	249
ENST00000445327	GRB7	chr17	37898969	+	ENST00000269554	PIP4K2B	chr17	36927525	-	4956	510	6	953	315
ENST00000394209	GRB7	chr17	37898969	+	ENST00000269554	PIP4K2B	chr17	36927525	-	5017	571	106	1014	302
ENST00000394204	GRB7	chr17	37898969	+	ENST00000269554	PIP4K2B	chr17	36927525	-	4802	356	50	799	249

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000309156	ENST00000269554	GRB7	chr17	37898969	+	PIP4K2B	chr17	36927525	-	0.002911037	0.99708897
ENST00000309185	ENST00000269554	GRB7	chr17	37898969	+	PIP4K2B	chr17	36927525	-	0.002897789	0.9971022
ENST00000394211	ENST00000269554	GRB7	chr17	37898969	+	PIP4K2B	chr17	36927525	-	0.00297203	0.99702793
ENST00000445327	ENST00000269554	GRB7	chr17	37898969	+	PIP4K2B	chr17	36927525	-	0.00172065	0.99827933
ENST00000394209	ENST00000269554	GRB7	chr17	37898969	+	PIP4K2B	chr17	36927525	-	0.003242225	0.9967578
ENST00000394204	ENST00000269554	GRB7	chr17	37898969	+	PIP4K2B	chr17	36927525	-	0.003033314	0.99696666

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Fusion Genomic Features for GRB7-PIP4K2B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for GRB7-PIP4K2B

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:37898969/chr17:36927525)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GRB7

chr17:37898969

chr17:36927525

ENST00000309156

100_186

102

533.0

Domain

Ras-associating

Hgene

GRB7

chr17:37898969

chr17:36927525

ENST00000309156

229_338

102

533.0

Domain

Hgene

GRB7

chr17:37898969

chr17:36927525

ENST00000309156

431_527

102

533.0

Domain

SH2

Hgene

GRB7

chr17:37898969

chr17:36927525

ENST00000309185

100_186

102

558.6666666666666

Domain

Ras-associating

Hgene

GRB7

chr17:37898969

chr17:36927525

ENST00000309185

229_338

102

558.6666666666666

Domain

Hgene

GRB7

chr17:37898969

chr17:36927525

ENST00000309185

431_527

102

558.6666666666666

Domain

SH2

Hgene

GRB7

chr17:37898969

chr17:36927525

ENST00000394204

100_186

102

464.0

Domain

Ras-associating

Hgene

GRB7

chr17:37898969

chr17:36927525

ENST00000394204

229_338

102

464.0

Domain

Hgene

GRB7

chr17:37898969

chr17:36927525

ENST00000394204

431_527

102

464.0

Domain

SH2

Hgene

GRB7

chr17:37898969

chr17:36927525

ENST00000394209

100_186

102

533.0

Domain

Ras-associating

Hgene

GRB7

chr17:37898969

chr17:36927525

ENST00000394209

229_338

102

533.0

Domain

Hgene

GRB7

chr17:37898969

chr17:36927525

ENST00000394209

431_527

102

533.0

Domain

SH2

Hgene

GRB7

chr17:37898969

chr17:36927525

ENST00000394211

100_186

102

533.0

Domain

Ras-associating

Hgene

GRB7

chr17:37898969

chr17:36927525

ENST00000394211

229_338

102

533.0

Domain

Hgene

GRB7

chr17:37898969

chr17:36927525

ENST00000394211

431_527

102

533.0

Domain

SH2

Hgene

GRB7

chr17:37898969

chr17:36927525

ENST00000445327

100_186

125

556.0

Domain

Ras-associating

Hgene

GRB7

chr17:37898969

chr17:36927525

ENST00000445327

229_338

125

556.0

Domain

Hgene

GRB7

chr17:37898969

chr17:36927525

ENST00000445327

431_527

125

556.0

Domain

SH2

Tgene

PIP4K2B

chr17:37898969

chr17:36927525

ENST00000269554

38_415

269

417.0

Domain

PIPK

Tgene

PIP4K2B

chr17:37898969

chr17:36927525

ENST00000269554

201_204

269

417.0

Nucleotide binding

ATP or GTP

Tgene

PIP4K2B

chr17:37898969

chr17:36927525

ENST00000269554

214_216

269

417.0

Nucleotide binding

ATP or GTP

Tgene

PIP4K2B

chr17:37898969

chr17:36927525

ENST00000269554

96_98

269

417.0

Nucleotide binding

ATP or GTP

Top

Fusion Gene Sequence for GRB7-PIP4K2B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>34674_34674_1_GRB7-PIP4K2B_GRB7_chr17_37898969_ENST00000309156_PIP4K2B_chr17_36927525_ENST00000269554_length(transcript)=5009nt_BP=563nt
AAGATAATTTTAGTTTCCTTGGGCCTGGAATCTGGACACACAGGGCTCCCCCCCGCCTCTGACTTCTCTGTCCGAAGTCGGGACACCCTC
CTACCACCTGTAGAGAAGCGGGAGTGGATCTGAAATAAAATCCAGGAATCTGGGGGTTCCTAGACGGAGCCAGACTTCGGAACGGGTGTC
CTGCTACTCCTGCTGGGGCTCCTCCAGGACAAGGGCACACAACTGGTTCCGTTAAGCCCCTCTCTTGCTCAGACGCCATGGAGCTGGATC
TGTCTCCACCTCATCTTAGCAGCTCTCCGGAAGACCTTTGCCCAGCCCCTGGGACCCCTCCTGGGACTCCCCGGCCCCCTGATACCCCTC
TGCCTGAGGAGGTAAAGAGGTCCCAGCCTCTCCTCATCCCAACCACCGGCAGGAAACTTCGAGAGGAGGAGAGGCGTGCCACCTCCCTCC
CCTCTATCCCCAACCCCTTCCCTGAGCTCTGCAGTCCTCCCTCACAGAGCCCAATTCTCGGGGGCCCCTCCAGTGCAAGGGGGCTGCTCC
CCCGCGATGCCAGCCGCCCCCATTTCTTGGCACAGCTGAAGATCATGGACTACAGCCTGCTGGTGGGCATCCACGACGTGGACCGGGCAG
AGCAGGAGGAGATGGAGGTGGAGGAGCGGGCAGAGGACGAGGAGTGTGAGAATGATGGGGTGGGTGGCAACCTACTCTGCTCCTATGGCA
CACCTCCGGACAGCCCTGGCAACCTCCTCAGCTTTCCTCGGTTCTTTGGTCCTGGGGAATTCGACCCCTCTGTTGACGTCTATGCCATGA
AAAGCCATGAAAGTTCCCCCAAGAAGGAGGTGTATTTCATGGCCATCATTGATATCCTCACGCCATACGATACAAAGAAGAAAGCTGCAC
ATGCTGCCAAAACGGTGAAACACGGGGCAGGGGCCGAGATCTCGACTGTGAACCCTGAGCAGTACTCCAAACGCTTCAACGAGTTTATGT
CCAACATCCTGACGTAGTTCTCTTCTACCTTCAGCCAGAGCCAGAGAGCTGGATATGGGGTCGGGGATCGGGAGTTAGGGAGAAGGGTGT
ATTTGGGCTAGATGGGAGGGTGGGAGCAGAGTCGGGTTTGGGAGGGCTTTAGCAATGAGACTGCAGCCTGTGACACCGAAAGAGACTTTA
GCTGAAGAGGAGGGGGATGTGCTGTGTGTGCACCTGCTCACAGGATGTAACCCCACCTTCTGCTTACCCTTGATTTTTTCTCCCCATTTG
ACACCCAGGTTAAAAAGGGGTTCCCTTTTTGGTACCTTGTAACCTTTTAAGATACCTTGGGGCTAGAGATGACTTCGTGGGTTTATTTGG
GTTTTGTTTCTGAAATTTCATTGCTCCAGGTTTGCTATTTATAATCATATTTCATCAGCCTACCCACCCTCCCCATCTTTGCTGAGCTCT
CAGTTCCCTTCAATTAAAGAGATACCCGGTAGACCCAGCACAAGGGTCCTTCCAGAACCAAGTGCTATGGATGCCAGATTGGAGAGGTCA
GACACCTCGCCCTGCTGCATTTGCTCTTGTCTGGATTAACTTTGTAATTTATGGAGTATTGTGCACAACTTCCTCCACCTTTCCCTTGGA
TTCAAGTGAAAACTGTTGCATTATTCCTCCATCCTGTCTGGAATACACCAGGTCAACACCAGAGATCTCAGATCAGAATCAGAGATCTCA
GAGGGGAATAAGTTCATCCTCATGGGATGGTGAGGGGCAGGAAAGCGGCTGGGCTCTTGGACACCTGGTTCTCAGAGAACCCTGTGATGA
TCACCCAAGCCCCAGGCTGTCTTAGCCCCTGGAGTTCAGAAGTCCTCTCTGTAAAGCCTGCCTCCCACTAGGTCAAGAGGAACTAGAGTA
CCTTTGGATTTATCAGGACCCTCATGTTTAAATGGTTATTTCCCTTTGGGAAAACTTCAGAAACTGATGTATCAAATGAGGCCCTGTGCC
CTCGATCTATTTCCTTCTTCCTTCTGACCTCCTCCCAGGCACTCTTACTTCTAGCCGAACTCTTAGCTCTGGGCAGATCTCCAAGCGCCT
GGAGTGCTTTTTAGCAGAGACACCTCGTTAAGCTCCGGGATGACCTTGTAGGAGATCTGTCTCCCTGTGCCTGGAGAGTTACAGCCAGCA
AGGTGCCCCCATCTTAGAGTGTGGTGTCCAAACGTGAGGTGGCTTCCTAGTTACATGAGGATGTGATCCAGGAAATCCAGTTTGGAGGCT
TGATGTGGGTTTTGACCTGGCCTCAGCCTTGGGGCTGTTTTTCCTTGTTGCCCCGCTCTAGACTTTTAGCAGATCTGCAGCCCACAGGCT
TTTTTGGAAGGAGTGGCTTCCTGCAGGTGTTCCACCTGCCTTCGGAGCCTGCCACCCAGGCCCTCAGAACTGAGCCACAGGCTGCTCTGG
CCAGGAGAGAAACAGCTCTGTTGTTCTGCATTGGGGGAGGTACATTCCTGCATCTTCTCACCCCCTCAACCAGGAACTGGGGATTTGGGA
TGAGATATGGTCAGACTTGTAGATAACCCCAAAGATGTGAAGATCGCTTGTGAAACCATTTTGAATGAATAGATTGGTTTCCTGTGGCTC
CCTCCAAACCTGGCCAAGCCCAGCTTCCGAAGCAGGAACCAGCACTGTCTCTGTGCCTGACTCACAGCATATAGGTCAGGAAAGAATGGA
GACGGCATTCTTGGACTTCACTGGGGCTGCTGGATTGGATGGGAAACCTTCTGGAAGAGGCAGATGGGGGTCAAACCACTGCCTTGGCCC
CAGGAAGGGGCCATAGGTAGGTCTGAACAACTGCCGCAAGACCACTACATGACTTAGGGAACTTGAAACCAACTGGCTCATGGAGAAAAC
AAATTTGACTTGGGAAAGGGATTATGTAGGAATAATGTTTGGACTTGATTTCCCCACGTCATAATGAAGAATGGAAGTTTGGATCTGCTC
CTCGTCAGGCGCAGCATCTCTGAAGCTTGGAAAGCTGTCTTCCAGCAGCCTCCGTGGCCTCGGGTTCCTACCGGCTTCTCTGCATTTGGT
CTGCTGATCATGTTGCCATAATGTGTATGGAAAGTGTAACACATTCTTACTGGTTAAAGACGACTACCAGGTATCTAACTTGTTTAACAT
TGAGTTTGTGTGTGTGTGTGTATGTTTGTGTGTTTTGTATATTGTTTACATTTTGAGAGGTAGCATTCTGTTTCAAATGCTTTTTGTTTT
TCTGACAGTATTGTTGACTGGGTCATAACATTTTGAGCTGTGGTTTGGTGGATTTTCAATTTTTTTTTTTAAAGGTCATTCGCTGTGCTA
TCTTCAAAACCTTGAGTTTGGCCCCCAATTTTTGGCATTCAAATGTTTAAAAGCTATTTATCTTGGTTTATACAAGTTTCCTTTCTCTTC
TTTTTGTCATGGTATTCTATTTGGTCTGCAGTTTGAATGTAGAGAAAGTGGACTGATCCCCCAAGCGTTGTCTGCCCCCACTCTTTCCTC
CTTGGGTCCCGCCATTCTTTTACTGGGCAGTCGAGGGCATTGGAGGGGAAGTGACTGCCCTCAGCCTCACTCCCTGGGGCCATGAAGAAA
AGCTAAACAGTCTCATGGCATCTCAGAATAATGTTGGGTCTCCCAAGAAGAAAGGTGTAAGAATAACGACATGGCTGATTAGGCGAGGCC
AGGATAGGGCTAAGGCCAGGATTCCTGGCTGGCATCCAGTCACCCCTTCTCCCATCCTTCCCCCTCTTCTTCCACAAGTCCGCAGCCGAG
ACACTGTAGTCTCCCAGCCACAGTGATGAGTGCCCTGGAGACTCCACTGACCTCTAGATGAAGGCCCCTGGCCCTGGTTCCTGTTAATTA
ACCTCTGGGTCTTTGAGTCCCCCAGCACAAACTTCTTTCCTGTACCCTGCGGCTTGGGGTCACAGGGCATGCCGGGAAGCCACAGCTGAG
GGGCGCAGACTGAAGCAGTGCTCCACCTCTCCTTCTTTAGCTCAGGGGTTGCTGGTCTGTGGCAGGCGCCACGAGTGGCCCCTGTGGCTG
TTCTCAGTGGCAGTCTCTTAAGTTCCCACCACAGGCAGCTCTTTATCCCCTCTCCCTACTTGACTCTTTCTCTTGCCTGTGCTTTTGGCC
TCAAACAGGCCTGCTGGTAGCGCTCAGGGCGTGAGGCTACACTCCTGCCCTGCCTTTCCTGTCTTCATGGTCTGCCAGGGCATACCTTGG
GGAGGTGGACCAAAGACCCAGGACTTTTTGCAGTAGCCAGTCCTACCCCCCAGTTGTCTTTTTACCAATTCAGGGTGGGAGAGAAAACTG
CAGCACCCCAGCATGTGAGTTACTCAGGTGTTGGGGGCTAGAAGGGACAGTGCGTTTAAACAACACTCAGAGCTCTGGCCTTAAACCTGT
GGCCCCCCAAGTCTAGGAGCCTCATCTCTTCCTGGCAGTCATGCGGGCAGGAGGTCCTGAAAGGGAAAACCCATTCAGACAACTGTTCCC
CAATCTACCAGCCATCTGCAGGGGTCAGTGACCGTGGCCCTCTCCCTCCTCTAGAATGTGCCACTTATGAAGAGTGCCCCATGGGGAAAA
GGAGACTCAGCTGTCCCTTGGCAGCTTGTGCCAGTATCCCAGGGCAGAAGTTTCCACAGGAGCCTCTTGCCCTTGCGCAGAGCCACTGTG
AGAGGCGGTGGGAGCCAACACCCTTGGGGGAGGGGGCAGTACTGCTCGGCACATCCCAGCATCAGGTCAGATCATTGAAATTAAAAAATG
TGAATTAAGTTCATATCCACCTTTTGGGGAAGCAGGACAAACCACCACCCCACCAAGTGTGTGACTTCTCCATATCCCACTGCAGTTTCC
ATTTTTTAAATGGGAATTTTCAATCCCCTGTGCTTGTCTAACGTCTGCTTTAAAAAGTTTGAGACCCTGTTACTGTTTGAAAATGCATGC

>34674_34674_1_GRB7-PIP4K2B_GRB7_chr17_37898969_ENST00000309156_PIP4K2B_chr17_36927525_ENST00000269554_length(amino acids)=249AA_BP=19
MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSA
RGLLPRDASRPHFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVD

--------------------------------------------------------------
>34674_34674_2_GRB7-PIP4K2B_GRB7_chr17_37898969_ENST00000309185_PIP4K2B_chr17_36927525_ENST00000269554_length(transcript)=5002nt_BP=556nt
TTTTAGTTTCCTTGGGCCTGGAATCTGGACACACAGGGCTCCCCCCCGCCTCTGACTTCTCTGTCCGAAGTCGGGACACCCTCCTACCAC
CTGTAGAGAAGCGGGAGTGGATCTGAAATAAAATCCAGGAATCTGGGGGTTCCTAGACGGAGCCAGACTTCGGAACGGGTGTCCTGCTAC
TCCTGCTGGGGCTCCTCCAGGACAAGGGCACACAACTGGTTCCGTTAAGCCCCTCTCTTGCTCAGACGCCATGGAGCTGGATCTGTCTCC
ACCTCATCTTAGCAGCTCTCCGGAAGACCTTTGCCCAGCCCCTGGGACCCCTCCTGGGACTCCCCGGCCCCCTGATACCCCTCTGCCTGA
GGAGGTAAAGAGGTCCCAGCCTCTCCTCATCCCAACCACCGGCAGGAAACTTCGAGAGGAGGAGAGGCGTGCCACCTCCCTCCCCTCTAT
CCCCAACCCCTTCCCTGAGCTCTGCAGTCCTCCCTCACAGAGCCCAATTCTCGGGGGCCCCTCCAGTGCAAGGGGGCTGCTCCCCCGCGA
TGCCAGCCGCCCCCATTTCTTGGCACAGCTGAAGATCATGGACTACAGCCTGCTGGTGGGCATCCACGACGTGGACCGGGCAGAGCAGGA
GGAGATGGAGGTGGAGGAGCGGGCAGAGGACGAGGAGTGTGAGAATGATGGGGTGGGTGGCAACCTACTCTGCTCCTATGGCACACCTCC
GGACAGCCCTGGCAACCTCCTCAGCTTTCCTCGGTTCTTTGGTCCTGGGGAATTCGACCCCTCTGTTGACGTCTATGCCATGAAAAGCCA
TGAAAGTTCCCCCAAGAAGGAGGTGTATTTCATGGCCATCATTGATATCCTCACGCCATACGATACAAAGAAGAAAGCTGCACATGCTGC
CAAAACGGTGAAACACGGGGCAGGGGCCGAGATCTCGACTGTGAACCCTGAGCAGTACTCCAAACGCTTCAACGAGTTTATGTCCAACAT
CCTGACGTAGTTCTCTTCTACCTTCAGCCAGAGCCAGAGAGCTGGATATGGGGTCGGGGATCGGGAGTTAGGGAGAAGGGTGTATTTGGG
CTAGATGGGAGGGTGGGAGCAGAGTCGGGTTTGGGAGGGCTTTAGCAATGAGACTGCAGCCTGTGACACCGAAAGAGACTTTAGCTGAAG
AGGAGGGGGATGTGCTGTGTGTGCACCTGCTCACAGGATGTAACCCCACCTTCTGCTTACCCTTGATTTTTTCTCCCCATTTGACACCCA
GGTTAAAAAGGGGTTCCCTTTTTGGTACCTTGTAACCTTTTAAGATACCTTGGGGCTAGAGATGACTTCGTGGGTTTATTTGGGTTTTGT
TTCTGAAATTTCATTGCTCCAGGTTTGCTATTTATAATCATATTTCATCAGCCTACCCACCCTCCCCATCTTTGCTGAGCTCTCAGTTCC
CTTCAATTAAAGAGATACCCGGTAGACCCAGCACAAGGGTCCTTCCAGAACCAAGTGCTATGGATGCCAGATTGGAGAGGTCAGACACCT
CGCCCTGCTGCATTTGCTCTTGTCTGGATTAACTTTGTAATTTATGGAGTATTGTGCACAACTTCCTCCACCTTTCCCTTGGATTCAAGT
GAAAACTGTTGCATTATTCCTCCATCCTGTCTGGAATACACCAGGTCAACACCAGAGATCTCAGATCAGAATCAGAGATCTCAGAGGGGA
ATAAGTTCATCCTCATGGGATGGTGAGGGGCAGGAAAGCGGCTGGGCTCTTGGACACCTGGTTCTCAGAGAACCCTGTGATGATCACCCA
AGCCCCAGGCTGTCTTAGCCCCTGGAGTTCAGAAGTCCTCTCTGTAAAGCCTGCCTCCCACTAGGTCAAGAGGAACTAGAGTACCTTTGG
ATTTATCAGGACCCTCATGTTTAAATGGTTATTTCCCTTTGGGAAAACTTCAGAAACTGATGTATCAAATGAGGCCCTGTGCCCTCGATC
TATTTCCTTCTTCCTTCTGACCTCCTCCCAGGCACTCTTACTTCTAGCCGAACTCTTAGCTCTGGGCAGATCTCCAAGCGCCTGGAGTGC
TTTTTAGCAGAGACACCTCGTTAAGCTCCGGGATGACCTTGTAGGAGATCTGTCTCCCTGTGCCTGGAGAGTTACAGCCAGCAAGGTGCC
CCCATCTTAGAGTGTGGTGTCCAAACGTGAGGTGGCTTCCTAGTTACATGAGGATGTGATCCAGGAAATCCAGTTTGGAGGCTTGATGTG
GGTTTTGACCTGGCCTCAGCCTTGGGGCTGTTTTTCCTTGTTGCCCCGCTCTAGACTTTTAGCAGATCTGCAGCCCACAGGCTTTTTTGG
AAGGAGTGGCTTCCTGCAGGTGTTCCACCTGCCTTCGGAGCCTGCCACCCAGGCCCTCAGAACTGAGCCACAGGCTGCTCTGGCCAGGAG
AGAAACAGCTCTGTTGTTCTGCATTGGGGGAGGTACATTCCTGCATCTTCTCACCCCCTCAACCAGGAACTGGGGATTTGGGATGAGATA
TGGTCAGACTTGTAGATAACCCCAAAGATGTGAAGATCGCTTGTGAAACCATTTTGAATGAATAGATTGGTTTCCTGTGGCTCCCTCCAA
ACCTGGCCAAGCCCAGCTTCCGAAGCAGGAACCAGCACTGTCTCTGTGCCTGACTCACAGCATATAGGTCAGGAAAGAATGGAGACGGCA
TTCTTGGACTTCACTGGGGCTGCTGGATTGGATGGGAAACCTTCTGGAAGAGGCAGATGGGGGTCAAACCACTGCCTTGGCCCCAGGAAG
GGGCCATAGGTAGGTCTGAACAACTGCCGCAAGACCACTACATGACTTAGGGAACTTGAAACCAACTGGCTCATGGAGAAAACAAATTTG
ACTTGGGAAAGGGATTATGTAGGAATAATGTTTGGACTTGATTTCCCCACGTCATAATGAAGAATGGAAGTTTGGATCTGCTCCTCGTCA
GGCGCAGCATCTCTGAAGCTTGGAAAGCTGTCTTCCAGCAGCCTCCGTGGCCTCGGGTTCCTACCGGCTTCTCTGCATTTGGTCTGCTGA
TCATGTTGCCATAATGTGTATGGAAAGTGTAACACATTCTTACTGGTTAAAGACGACTACCAGGTATCTAACTTGTTTAACATTGAGTTT
GTGTGTGTGTGTGTATGTTTGTGTGTTTTGTATATTGTTTACATTTTGAGAGGTAGCATTCTGTTTCAAATGCTTTTTGTTTTTCTGACA
GTATTGTTGACTGGGTCATAACATTTTGAGCTGTGGTTTGGTGGATTTTCAATTTTTTTTTTTAAAGGTCATTCGCTGTGCTATCTTCAA
AACCTTGAGTTTGGCCCCCAATTTTTGGCATTCAAATGTTTAAAAGCTATTTATCTTGGTTTATACAAGTTTCCTTTCTCTTCTTTTTGT
CATGGTATTCTATTTGGTCTGCAGTTTGAATGTAGAGAAAGTGGACTGATCCCCCAAGCGTTGTCTGCCCCCACTCTTTCCTCCTTGGGT
CCCGCCATTCTTTTACTGGGCAGTCGAGGGCATTGGAGGGGAAGTGACTGCCCTCAGCCTCACTCCCTGGGGCCATGAAGAAAAGCTAAA
CAGTCTCATGGCATCTCAGAATAATGTTGGGTCTCCCAAGAAGAAAGGTGTAAGAATAACGACATGGCTGATTAGGCGAGGCCAGGATAG
GGCTAAGGCCAGGATTCCTGGCTGGCATCCAGTCACCCCTTCTCCCATCCTTCCCCCTCTTCTTCCACAAGTCCGCAGCCGAGACACTGT
AGTCTCCCAGCCACAGTGATGAGTGCCCTGGAGACTCCACTGACCTCTAGATGAAGGCCCCTGGCCCTGGTTCCTGTTAATTAACCTCTG
GGTCTTTGAGTCCCCCAGCACAAACTTCTTTCCTGTACCCTGCGGCTTGGGGTCACAGGGCATGCCGGGAAGCCACAGCTGAGGGGCGCA
GACTGAAGCAGTGCTCCACCTCTCCTTCTTTAGCTCAGGGGTTGCTGGTCTGTGGCAGGCGCCACGAGTGGCCCCTGTGGCTGTTCTCAG
TGGCAGTCTCTTAAGTTCCCACCACAGGCAGCTCTTTATCCCCTCTCCCTACTTGACTCTTTCTCTTGCCTGTGCTTTTGGCCTCAAACA
GGCCTGCTGGTAGCGCTCAGGGCGTGAGGCTACACTCCTGCCCTGCCTTTCCTGTCTTCATGGTCTGCCAGGGCATACCTTGGGGAGGTG
GACCAAAGACCCAGGACTTTTTGCAGTAGCCAGTCCTACCCCCCAGTTGTCTTTTTACCAATTCAGGGTGGGAGAGAAAACTGCAGCACC
CCAGCATGTGAGTTACTCAGGTGTTGGGGGCTAGAAGGGACAGTGCGTTTAAACAACACTCAGAGCTCTGGCCTTAAACCTGTGGCCCCC
CAAGTCTAGGAGCCTCATCTCTTCCTGGCAGTCATGCGGGCAGGAGGTCCTGAAAGGGAAAACCCATTCAGACAACTGTTCCCCAATCTA
CCAGCCATCTGCAGGGGTCAGTGACCGTGGCCCTCTCCCTCCTCTAGAATGTGCCACTTATGAAGAGTGCCCCATGGGGAAAAGGAGACT
CAGCTGTCCCTTGGCAGCTTGTGCCAGTATCCCAGGGCAGAAGTTTCCACAGGAGCCTCTTGCCCTTGCGCAGAGCCACTGTGAGAGGCG
GTGGGAGCCAACACCCTTGGGGGAGGGGGCAGTACTGCTCGGCACATCCCAGCATCAGGTCAGATCATTGAAATTAAAAAATGTGAATTA
AGTTCATATCCACCTTTTGGGGAAGCAGGACAAACCACCACCCCACCAAGTGTGTGACTTCTCCATATCCCACTGCAGTTTCCATTTTTT
AAATGGGAATTTTCAATCCCCTGTGCTTGTCTAACGTCTGCTTTAAAAAGTTTGAGACCCTGTTACTGTTTGAAAATGCATGCATGTTAC

>34674_34674_2_GRB7-PIP4K2B_GRB7_chr17_37898969_ENST00000309185_PIP4K2B_chr17_36927525_ENST00000269554_length(amino acids)=249AA_BP=19
MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSA
RGLLPRDASRPHFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVD

--------------------------------------------------------------
>34674_34674_3_GRB7-PIP4K2B_GRB7_chr17_37898969_ENST00000394204_PIP4K2B_chr17_36927525_ENST00000269554_length(transcript)=4802nt_BP=356nt
GACAAGGGCACACAACTGGTTCCGTTAAGCCCCTCTCTTGCTCAGACGCCATGGAGCTGGATCTGTCTCCACCTCATCTTAGCAGCTCTC
CGGAAGACCTTTGCCCAGCCCCTGGGACCCCTCCTGGGACTCCCCGGCCCCCTGATACCCCTCTGCCTGAGGAGGTAAAGAGGTCCCAGC
CTCTCCTCATCCCAACCACCGGCAGGAAACTTCGAGAGGAGGAGAGGCGTGCCACCTCCCTCCCCTCTATCCCCAACCCCTTCCCTGAGC
TCTGCAGTCCTCCCTCACAGAGCCCAATTCTCGGGGGCCCCTCCAGTGCAAGGGGGCTGCTCCCCCGCGATGCCAGCCGCCCCCATTTCT
TGGCACAGCTGAAGATCATGGACTACAGCCTGCTGGTGGGCATCCACGACGTGGACCGGGCAGAGCAGGAGGAGATGGAGGTGGAGGAGC
GGGCAGAGGACGAGGAGTGTGAGAATGATGGGGTGGGTGGCAACCTACTCTGCTCCTATGGCACACCTCCGGACAGCCCTGGCAACCTCC
TCAGCTTTCCTCGGTTCTTTGGTCCTGGGGAATTCGACCCCTCTGTTGACGTCTATGCCATGAAAAGCCATGAAAGTTCCCCCAAGAAGG
AGGTGTATTTCATGGCCATCATTGATATCCTCACGCCATACGATACAAAGAAGAAAGCTGCACATGCTGCCAAAACGGTGAAACACGGGG
CAGGGGCCGAGATCTCGACTGTGAACCCTGAGCAGTACTCCAAACGCTTCAACGAGTTTATGTCCAACATCCTGACGTAGTTCTCTTCTA
CCTTCAGCCAGAGCCAGAGAGCTGGATATGGGGTCGGGGATCGGGAGTTAGGGAGAAGGGTGTATTTGGGCTAGATGGGAGGGTGGGAGC
AGAGTCGGGTTTGGGAGGGCTTTAGCAATGAGACTGCAGCCTGTGACACCGAAAGAGACTTTAGCTGAAGAGGAGGGGGATGTGCTGTGT
GTGCACCTGCTCACAGGATGTAACCCCACCTTCTGCTTACCCTTGATTTTTTCTCCCCATTTGACACCCAGGTTAAAAAGGGGTTCCCTT
TTTGGTACCTTGTAACCTTTTAAGATACCTTGGGGCTAGAGATGACTTCGTGGGTTTATTTGGGTTTTGTTTCTGAAATTTCATTGCTCC
AGGTTTGCTATTTATAATCATATTTCATCAGCCTACCCACCCTCCCCATCTTTGCTGAGCTCTCAGTTCCCTTCAATTAAAGAGATACCC
GGTAGACCCAGCACAAGGGTCCTTCCAGAACCAAGTGCTATGGATGCCAGATTGGAGAGGTCAGACACCTCGCCCTGCTGCATTTGCTCT
TGTCTGGATTAACTTTGTAATTTATGGAGTATTGTGCACAACTTCCTCCACCTTTCCCTTGGATTCAAGTGAAAACTGTTGCATTATTCC
TCCATCCTGTCTGGAATACACCAGGTCAACACCAGAGATCTCAGATCAGAATCAGAGATCTCAGAGGGGAATAAGTTCATCCTCATGGGA
TGGTGAGGGGCAGGAAAGCGGCTGGGCTCTTGGACACCTGGTTCTCAGAGAACCCTGTGATGATCACCCAAGCCCCAGGCTGTCTTAGCC
CCTGGAGTTCAGAAGTCCTCTCTGTAAAGCCTGCCTCCCACTAGGTCAAGAGGAACTAGAGTACCTTTGGATTTATCAGGACCCTCATGT
TTAAATGGTTATTTCCCTTTGGGAAAACTTCAGAAACTGATGTATCAAATGAGGCCCTGTGCCCTCGATCTATTTCCTTCTTCCTTCTGA
CCTCCTCCCAGGCACTCTTACTTCTAGCCGAACTCTTAGCTCTGGGCAGATCTCCAAGCGCCTGGAGTGCTTTTTAGCAGAGACACCTCG
TTAAGCTCCGGGATGACCTTGTAGGAGATCTGTCTCCCTGTGCCTGGAGAGTTACAGCCAGCAAGGTGCCCCCATCTTAGAGTGTGGTGT
CCAAACGTGAGGTGGCTTCCTAGTTACATGAGGATGTGATCCAGGAAATCCAGTTTGGAGGCTTGATGTGGGTTTTGACCTGGCCTCAGC
CTTGGGGCTGTTTTTCCTTGTTGCCCCGCTCTAGACTTTTAGCAGATCTGCAGCCCACAGGCTTTTTTGGAAGGAGTGGCTTCCTGCAGG
TGTTCCACCTGCCTTCGGAGCCTGCCACCCAGGCCCTCAGAACTGAGCCACAGGCTGCTCTGGCCAGGAGAGAAACAGCTCTGTTGTTCT
GCATTGGGGGAGGTACATTCCTGCATCTTCTCACCCCCTCAACCAGGAACTGGGGATTTGGGATGAGATATGGTCAGACTTGTAGATAAC
CCCAAAGATGTGAAGATCGCTTGTGAAACCATTTTGAATGAATAGATTGGTTTCCTGTGGCTCCCTCCAAACCTGGCCAAGCCCAGCTTC
CGAAGCAGGAACCAGCACTGTCTCTGTGCCTGACTCACAGCATATAGGTCAGGAAAGAATGGAGACGGCATTCTTGGACTTCACTGGGGC
TGCTGGATTGGATGGGAAACCTTCTGGAAGAGGCAGATGGGGGTCAAACCACTGCCTTGGCCCCAGGAAGGGGCCATAGGTAGGTCTGAA
CAACTGCCGCAAGACCACTACATGACTTAGGGAACTTGAAACCAACTGGCTCATGGAGAAAACAAATTTGACTTGGGAAAGGGATTATGT
AGGAATAATGTTTGGACTTGATTTCCCCACGTCATAATGAAGAATGGAAGTTTGGATCTGCTCCTCGTCAGGCGCAGCATCTCTGAAGCT
TGGAAAGCTGTCTTCCAGCAGCCTCCGTGGCCTCGGGTTCCTACCGGCTTCTCTGCATTTGGTCTGCTGATCATGTTGCCATAATGTGTA
TGGAAAGTGTAACACATTCTTACTGGTTAAAGACGACTACCAGGTATCTAACTTGTTTAACATTGAGTTTGTGTGTGTGTGTGTATGTTT
GTGTGTTTTGTATATTGTTTACATTTTGAGAGGTAGCATTCTGTTTCAAATGCTTTTTGTTTTTCTGACAGTATTGTTGACTGGGTCATA
ACATTTTGAGCTGTGGTTTGGTGGATTTTCAATTTTTTTTTTTAAAGGTCATTCGCTGTGCTATCTTCAAAACCTTGAGTTTGGCCCCCA
ATTTTTGGCATTCAAATGTTTAAAAGCTATTTATCTTGGTTTATACAAGTTTCCTTTCTCTTCTTTTTGTCATGGTATTCTATTTGGTCT
GCAGTTTGAATGTAGAGAAAGTGGACTGATCCCCCAAGCGTTGTCTGCCCCCACTCTTTCCTCCTTGGGTCCCGCCATTCTTTTACTGGG
CAGTCGAGGGCATTGGAGGGGAAGTGACTGCCCTCAGCCTCACTCCCTGGGGCCATGAAGAAAAGCTAAACAGTCTCATGGCATCTCAGA
ATAATGTTGGGTCTCCCAAGAAGAAAGGTGTAAGAATAACGACATGGCTGATTAGGCGAGGCCAGGATAGGGCTAAGGCCAGGATTCCTG
GCTGGCATCCAGTCACCCCTTCTCCCATCCTTCCCCCTCTTCTTCCACAAGTCCGCAGCCGAGACACTGTAGTCTCCCAGCCACAGTGAT
GAGTGCCCTGGAGACTCCACTGACCTCTAGATGAAGGCCCCTGGCCCTGGTTCCTGTTAATTAACCTCTGGGTCTTTGAGTCCCCCAGCA
CAAACTTCTTTCCTGTACCCTGCGGCTTGGGGTCACAGGGCATGCCGGGAAGCCACAGCTGAGGGGCGCAGACTGAAGCAGTGCTCCACC
TCTCCTTCTTTAGCTCAGGGGTTGCTGGTCTGTGGCAGGCGCCACGAGTGGCCCCTGTGGCTGTTCTCAGTGGCAGTCTCTTAAGTTCCC
ACCACAGGCAGCTCTTTATCCCCTCTCCCTACTTGACTCTTTCTCTTGCCTGTGCTTTTGGCCTCAAACAGGCCTGCTGGTAGCGCTCAG
GGCGTGAGGCTACACTCCTGCCCTGCCTTTCCTGTCTTCATGGTCTGCCAGGGCATACCTTGGGGAGGTGGACCAAAGACCCAGGACTTT
TTGCAGTAGCCAGTCCTACCCCCCAGTTGTCTTTTTACCAATTCAGGGTGGGAGAGAAAACTGCAGCACCCCAGCATGTGAGTTACTCAG
GTGTTGGGGGCTAGAAGGGACAGTGCGTTTAAACAACACTCAGAGCTCTGGCCTTAAACCTGTGGCCCCCCAAGTCTAGGAGCCTCATCT
CTTCCTGGCAGTCATGCGGGCAGGAGGTCCTGAAAGGGAAAACCCATTCAGACAACTGTTCCCCAATCTACCAGCCATCTGCAGGGGTCA
GTGACCGTGGCCCTCTCCCTCCTCTAGAATGTGCCACTTATGAAGAGTGCCCCATGGGGAAAAGGAGACTCAGCTGTCCCTTGGCAGCTT
GTGCCAGTATCCCAGGGCAGAAGTTTCCACAGGAGCCTCTTGCCCTTGCGCAGAGCCACTGTGAGAGGCGGTGGGAGCCAACACCCTTGG
GGGAGGGGGCAGTACTGCTCGGCACATCCCAGCATCAGGTCAGATCATTGAAATTAAAAAATGTGAATTAAGTTCATATCCACCTTTTGG
GGAAGCAGGACAAACCACCACCCCACCAAGTGTGTGACTTCTCCATATCCCACTGCAGTTTCCATTTTTTAAATGGGAATTTTCAATCCC
CTGTGCTTGTCTAACGTCTGCTTTAAAAAGTTTGAGACCCTGTTACTGTTTGAAAATGCATGCATGTTACGATGAATCTCCAACCTGAGG

>34674_34674_3_GRB7-PIP4K2B_GRB7_chr17_37898969_ENST00000394204_PIP4K2B_chr17_36927525_ENST00000269554_length(amino acids)=249AA_BP=19
MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSA
RGLLPRDASRPHFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVD

--------------------------------------------------------------
>34674_34674_4_GRB7-PIP4K2B_GRB7_chr17_37898969_ENST00000394209_PIP4K2B_chr17_36927525_ENST00000269554_length(transcript)=5017nt_BP=571nt
AGGCAAACCCCAGCCTTGGACTGGCCCTCTCTGATCTCTGAGGCCAGGCTCTAATGTGATTTGAATCTACTTCTAACCCCTTCCAAGCAC
TGCCCTCCCGAATTCTCTGCTCCTCTCCCCACCCCACTGTTGGTCTGTGATTTCGAGGCAGGCGTGGCCCCCTGCAGCCTGGAATGAAGT
CACTGGGGCTGTTTGGAGACCGGGGCTGTTTGGAGGACAAGGGCACACAACTGGTTCCGTTAAGCCCCTCTCTTGCTCAGACGCCATGGA
GCTGGATCTGTCTCCACCTCATCTTAGCAGCTCTCCGGAAGACCTTTGCCCAGCCCCTGGGACCCCTCCTGGGACTCCCCGGCCCCCTGA
TACCCCTCTGCCTGAGGAGGTAAAGAGGTCCCAGCCTCTCCTCATCCCAACCACCGGCAGGAAACTTCGAGAGGAGGAGAGGCGTGCCAC
CTCCCTCCCCTCTATCCCCAACCCCTTCCCTGAGCTCTGCAGTCCTCCCTCACAGAGCCCAATTCTCGGGGGCCCCTCCAGTGCAAGGGG
GCTGCTCCCCCGCGATGCCAGCCGCCCCCATTTCTTGGCACAGCTGAAGATCATGGACTACAGCCTGCTGGTGGGCATCCACGACGTGGA
CCGGGCAGAGCAGGAGGAGATGGAGGTGGAGGAGCGGGCAGAGGACGAGGAGTGTGAGAATGATGGGGTGGGTGGCAACCTACTCTGCTC
CTATGGCACACCTCCGGACAGCCCTGGCAACCTCCTCAGCTTTCCTCGGTTCTTTGGTCCTGGGGAATTCGACCCCTCTGTTGACGTCTA
TGCCATGAAAAGCCATGAAAGTTCCCCCAAGAAGGAGGTGTATTTCATGGCCATCATTGATATCCTCACGCCATACGATACAAAGAAGAA
AGCTGCACATGCTGCCAAAACGGTGAAACACGGGGCAGGGGCCGAGATCTCGACTGTGAACCCTGAGCAGTACTCCAAACGCTTCAACGA
GTTTATGTCCAACATCCTGACGTAGTTCTCTTCTACCTTCAGCCAGAGCCAGAGAGCTGGATATGGGGTCGGGGATCGGGAGTTAGGGAG
AAGGGTGTATTTGGGCTAGATGGGAGGGTGGGAGCAGAGTCGGGTTTGGGAGGGCTTTAGCAATGAGACTGCAGCCTGTGACACCGAAAG
AGACTTTAGCTGAAGAGGAGGGGGATGTGCTGTGTGTGCACCTGCTCACAGGATGTAACCCCACCTTCTGCTTACCCTTGATTTTTTCTC
CCCATTTGACACCCAGGTTAAAAAGGGGTTCCCTTTTTGGTACCTTGTAACCTTTTAAGATACCTTGGGGCTAGAGATGACTTCGTGGGT
TTATTTGGGTTTTGTTTCTGAAATTTCATTGCTCCAGGTTTGCTATTTATAATCATATTTCATCAGCCTACCCACCCTCCCCATCTTTGC
TGAGCTCTCAGTTCCCTTCAATTAAAGAGATACCCGGTAGACCCAGCACAAGGGTCCTTCCAGAACCAAGTGCTATGGATGCCAGATTGG
AGAGGTCAGACACCTCGCCCTGCTGCATTTGCTCTTGTCTGGATTAACTTTGTAATTTATGGAGTATTGTGCACAACTTCCTCCACCTTT
CCCTTGGATTCAAGTGAAAACTGTTGCATTATTCCTCCATCCTGTCTGGAATACACCAGGTCAACACCAGAGATCTCAGATCAGAATCAG
AGATCTCAGAGGGGAATAAGTTCATCCTCATGGGATGGTGAGGGGCAGGAAAGCGGCTGGGCTCTTGGACACCTGGTTCTCAGAGAACCC
TGTGATGATCACCCAAGCCCCAGGCTGTCTTAGCCCCTGGAGTTCAGAAGTCCTCTCTGTAAAGCCTGCCTCCCACTAGGTCAAGAGGAA
CTAGAGTACCTTTGGATTTATCAGGACCCTCATGTTTAAATGGTTATTTCCCTTTGGGAAAACTTCAGAAACTGATGTATCAAATGAGGC
CCTGTGCCCTCGATCTATTTCCTTCTTCCTTCTGACCTCCTCCCAGGCACTCTTACTTCTAGCCGAACTCTTAGCTCTGGGCAGATCTCC
AAGCGCCTGGAGTGCTTTTTAGCAGAGACACCTCGTTAAGCTCCGGGATGACCTTGTAGGAGATCTGTCTCCCTGTGCCTGGAGAGTTAC
AGCCAGCAAGGTGCCCCCATCTTAGAGTGTGGTGTCCAAACGTGAGGTGGCTTCCTAGTTACATGAGGATGTGATCCAGGAAATCCAGTT
TGGAGGCTTGATGTGGGTTTTGACCTGGCCTCAGCCTTGGGGCTGTTTTTCCTTGTTGCCCCGCTCTAGACTTTTAGCAGATCTGCAGCC
CACAGGCTTTTTTGGAAGGAGTGGCTTCCTGCAGGTGTTCCACCTGCCTTCGGAGCCTGCCACCCAGGCCCTCAGAACTGAGCCACAGGC
TGCTCTGGCCAGGAGAGAAACAGCTCTGTTGTTCTGCATTGGGGGAGGTACATTCCTGCATCTTCTCACCCCCTCAACCAGGAACTGGGG
ATTTGGGATGAGATATGGTCAGACTTGTAGATAACCCCAAAGATGTGAAGATCGCTTGTGAAACCATTTTGAATGAATAGATTGGTTTCC
TGTGGCTCCCTCCAAACCTGGCCAAGCCCAGCTTCCGAAGCAGGAACCAGCACTGTCTCTGTGCCTGACTCACAGCATATAGGTCAGGAA
AGAATGGAGACGGCATTCTTGGACTTCACTGGGGCTGCTGGATTGGATGGGAAACCTTCTGGAAGAGGCAGATGGGGGTCAAACCACTGC
CTTGGCCCCAGGAAGGGGCCATAGGTAGGTCTGAACAACTGCCGCAAGACCACTACATGACTTAGGGAACTTGAAACCAACTGGCTCATG
GAGAAAACAAATTTGACTTGGGAAAGGGATTATGTAGGAATAATGTTTGGACTTGATTTCCCCACGTCATAATGAAGAATGGAAGTTTGG
ATCTGCTCCTCGTCAGGCGCAGCATCTCTGAAGCTTGGAAAGCTGTCTTCCAGCAGCCTCCGTGGCCTCGGGTTCCTACCGGCTTCTCTG
CATTTGGTCTGCTGATCATGTTGCCATAATGTGTATGGAAAGTGTAACACATTCTTACTGGTTAAAGACGACTACCAGGTATCTAACTTG
TTTAACATTGAGTTTGTGTGTGTGTGTGTATGTTTGTGTGTTTTGTATATTGTTTACATTTTGAGAGGTAGCATTCTGTTTCAAATGCTT
TTTGTTTTTCTGACAGTATTGTTGACTGGGTCATAACATTTTGAGCTGTGGTTTGGTGGATTTTCAATTTTTTTTTTTAAAGGTCATTCG
CTGTGCTATCTTCAAAACCTTGAGTTTGGCCCCCAATTTTTGGCATTCAAATGTTTAAAAGCTATTTATCTTGGTTTATACAAGTTTCCT
TTCTCTTCTTTTTGTCATGGTATTCTATTTGGTCTGCAGTTTGAATGTAGAGAAAGTGGACTGATCCCCCAAGCGTTGTCTGCCCCCACT
CTTTCCTCCTTGGGTCCCGCCATTCTTTTACTGGGCAGTCGAGGGCATTGGAGGGGAAGTGACTGCCCTCAGCCTCACTCCCTGGGGCCA
TGAAGAAAAGCTAAACAGTCTCATGGCATCTCAGAATAATGTTGGGTCTCCCAAGAAGAAAGGTGTAAGAATAACGACATGGCTGATTAG
GCGAGGCCAGGATAGGGCTAAGGCCAGGATTCCTGGCTGGCATCCAGTCACCCCTTCTCCCATCCTTCCCCCTCTTCTTCCACAAGTCCG
CAGCCGAGACACTGTAGTCTCCCAGCCACAGTGATGAGTGCCCTGGAGACTCCACTGACCTCTAGATGAAGGCCCCTGGCCCTGGTTCCT
GTTAATTAACCTCTGGGTCTTTGAGTCCCCCAGCACAAACTTCTTTCCTGTACCCTGCGGCTTGGGGTCACAGGGCATGCCGGGAAGCCA
CAGCTGAGGGGCGCAGACTGAAGCAGTGCTCCACCTCTCCTTCTTTAGCTCAGGGGTTGCTGGTCTGTGGCAGGCGCCACGAGTGGCCCC
TGTGGCTGTTCTCAGTGGCAGTCTCTTAAGTTCCCACCACAGGCAGCTCTTTATCCCCTCTCCCTACTTGACTCTTTCTCTTGCCTGTGC
TTTTGGCCTCAAACAGGCCTGCTGGTAGCGCTCAGGGCGTGAGGCTACACTCCTGCCCTGCCTTTCCTGTCTTCATGGTCTGCCAGGGCA
TACCTTGGGGAGGTGGACCAAAGACCCAGGACTTTTTGCAGTAGCCAGTCCTACCCCCCAGTTGTCTTTTTACCAATTCAGGGTGGGAGA
GAAAACTGCAGCACCCCAGCATGTGAGTTACTCAGGTGTTGGGGGCTAGAAGGGACAGTGCGTTTAAACAACACTCAGAGCTCTGGCCTT
AAACCTGTGGCCCCCCAAGTCTAGGAGCCTCATCTCTTCCTGGCAGTCATGCGGGCAGGAGGTCCTGAAAGGGAAAACCCATTCAGACAA
CTGTTCCCCAATCTACCAGCCATCTGCAGGGGTCAGTGACCGTGGCCCTCTCCCTCCTCTAGAATGTGCCACTTATGAAGAGTGCCCCAT
GGGGAAAAGGAGACTCAGCTGTCCCTTGGCAGCTTGTGCCAGTATCCCAGGGCAGAAGTTTCCACAGGAGCCTCTTGCCCTTGCGCAGAG
CCACTGTGAGAGGCGGTGGGAGCCAACACCCTTGGGGGAGGGGGCAGTACTGCTCGGCACATCCCAGCATCAGGTCAGATCATTGAAATT
AAAAAATGTGAATTAAGTTCATATCCACCTTTTGGGGAAGCAGGACAAACCACCACCCCACCAAGTGTGTGACTTCTCCATATCCCACTG
CAGTTTCCATTTTTTAAATGGGAATTTTCAATCCCCTGTGCTTGTCTAACGTCTGCTTTAAAAAGTTTGAGACCCTGTTACTGTTTGAAA

>34674_34674_4_GRB7-PIP4K2B_GRB7_chr17_37898969_ENST00000394209_PIP4K2B_chr17_36927525_ENST00000269554_length(amino acids)=302AA_BP=72
MLLSPPHCWSVISRQAWPPAAWNEVTGAVWRPGLFGGQGHTTGSVKPLSCSDAMELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPE
EVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRPHFLAQLKIMDYSLLVGIHDVDRAEQE
EMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAA

--------------------------------------------------------------
>34674_34674_5_GRB7-PIP4K2B_GRB7_chr17_37898969_ENST00000394211_PIP4K2B_chr17_36927525_ENST00000269554_length(transcript)=4858nt_BP=412nt
CGTCTCCCTCCCTGAAGACGTGGTCCCAGCCGGGTGTCCTGACGCTCGGGGTTCAGGACAAGGGCACACAACTGGTTCCGTTAAGCCCCT
CTCTTGCTCAGACGCCATGGAGCTGGATCTGTCTCCACCTCATCTTAGCAGCTCTCCGGAAGACCTTTGCCCAGCCCCTGGGACCCCTCC
TGGGACTCCCCGGCCCCCTGATACCCCTCTGCCTGAGGAGGTAAAGAGGTCCCAGCCTCTCCTCATCCCAACCACCGGCAGGAAACTTCG
AGAGGAGGAGAGGCGTGCCACCTCCCTCCCCTCTATCCCCAACCCCTTCCCTGAGCTCTGCAGTCCTCCCTCACAGAGCCCAATTCTCGG
GGGCCCCTCCAGTGCAAGGGGGCTGCTCCCCCGCGATGCCAGCCGCCCCCATTTCTTGGCACAGCTGAAGATCATGGACTACAGCCTGCT
GGTGGGCATCCACGACGTGGACCGGGCAGAGCAGGAGGAGATGGAGGTGGAGGAGCGGGCAGAGGACGAGGAGTGTGAGAATGATGGGGT
GGGTGGCAACCTACTCTGCTCCTATGGCACACCTCCGGACAGCCCTGGCAACCTCCTCAGCTTTCCTCGGTTCTTTGGTCCTGGGGAATT
CGACCCCTCTGTTGACGTCTATGCCATGAAAAGCCATGAAAGTTCCCCCAAGAAGGAGGTGTATTTCATGGCCATCATTGATATCCTCAC
GCCATACGATACAAAGAAGAAAGCTGCACATGCTGCCAAAACGGTGAAACACGGGGCAGGGGCCGAGATCTCGACTGTGAACCCTGAGCA
GTACTCCAAACGCTTCAACGAGTTTATGTCCAACATCCTGACGTAGTTCTCTTCTACCTTCAGCCAGAGCCAGAGAGCTGGATATGGGGT
CGGGGATCGGGAGTTAGGGAGAAGGGTGTATTTGGGCTAGATGGGAGGGTGGGAGCAGAGTCGGGTTTGGGAGGGCTTTAGCAATGAGAC
TGCAGCCTGTGACACCGAAAGAGACTTTAGCTGAAGAGGAGGGGGATGTGCTGTGTGTGCACCTGCTCACAGGATGTAACCCCACCTTCT
GCTTACCCTTGATTTTTTCTCCCCATTTGACACCCAGGTTAAAAAGGGGTTCCCTTTTTGGTACCTTGTAACCTTTTAAGATACCTTGGG
GCTAGAGATGACTTCGTGGGTTTATTTGGGTTTTGTTTCTGAAATTTCATTGCTCCAGGTTTGCTATTTATAATCATATTTCATCAGCCT
ACCCACCCTCCCCATCTTTGCTGAGCTCTCAGTTCCCTTCAATTAAAGAGATACCCGGTAGACCCAGCACAAGGGTCCTTCCAGAACCAA
GTGCTATGGATGCCAGATTGGAGAGGTCAGACACCTCGCCCTGCTGCATTTGCTCTTGTCTGGATTAACTTTGTAATTTATGGAGTATTG
TGCACAACTTCCTCCACCTTTCCCTTGGATTCAAGTGAAAACTGTTGCATTATTCCTCCATCCTGTCTGGAATACACCAGGTCAACACCA
GAGATCTCAGATCAGAATCAGAGATCTCAGAGGGGAATAAGTTCATCCTCATGGGATGGTGAGGGGCAGGAAAGCGGCTGGGCTCTTGGA
CACCTGGTTCTCAGAGAACCCTGTGATGATCACCCAAGCCCCAGGCTGTCTTAGCCCCTGGAGTTCAGAAGTCCTCTCTGTAAAGCCTGC
CTCCCACTAGGTCAAGAGGAACTAGAGTACCTTTGGATTTATCAGGACCCTCATGTTTAAATGGTTATTTCCCTTTGGGAAAACTTCAGA
AACTGATGTATCAAATGAGGCCCTGTGCCCTCGATCTATTTCCTTCTTCCTTCTGACCTCCTCCCAGGCACTCTTACTTCTAGCCGAACT
CTTAGCTCTGGGCAGATCTCCAAGCGCCTGGAGTGCTTTTTAGCAGAGACACCTCGTTAAGCTCCGGGATGACCTTGTAGGAGATCTGTC
TCCCTGTGCCTGGAGAGTTACAGCCAGCAAGGTGCCCCCATCTTAGAGTGTGGTGTCCAAACGTGAGGTGGCTTCCTAGTTACATGAGGA
TGTGATCCAGGAAATCCAGTTTGGAGGCTTGATGTGGGTTTTGACCTGGCCTCAGCCTTGGGGCTGTTTTTCCTTGTTGCCCCGCTCTAG
ACTTTTAGCAGATCTGCAGCCCACAGGCTTTTTTGGAAGGAGTGGCTTCCTGCAGGTGTTCCACCTGCCTTCGGAGCCTGCCACCCAGGC
CCTCAGAACTGAGCCACAGGCTGCTCTGGCCAGGAGAGAAACAGCTCTGTTGTTCTGCATTGGGGGAGGTACATTCCTGCATCTTCTCAC
CCCCTCAACCAGGAACTGGGGATTTGGGATGAGATATGGTCAGACTTGTAGATAACCCCAAAGATGTGAAGATCGCTTGTGAAACCATTT
TGAATGAATAGATTGGTTTCCTGTGGCTCCCTCCAAACCTGGCCAAGCCCAGCTTCCGAAGCAGGAACCAGCACTGTCTCTGTGCCTGAC
TCACAGCATATAGGTCAGGAAAGAATGGAGACGGCATTCTTGGACTTCACTGGGGCTGCTGGATTGGATGGGAAACCTTCTGGAAGAGGC
AGATGGGGGTCAAACCACTGCCTTGGCCCCAGGAAGGGGCCATAGGTAGGTCTGAACAACTGCCGCAAGACCACTACATGACTTAGGGAA
CTTGAAACCAACTGGCTCATGGAGAAAACAAATTTGACTTGGGAAAGGGATTATGTAGGAATAATGTTTGGACTTGATTTCCCCACGTCA
TAATGAAGAATGGAAGTTTGGATCTGCTCCTCGTCAGGCGCAGCATCTCTGAAGCTTGGAAAGCTGTCTTCCAGCAGCCTCCGTGGCCTC
GGGTTCCTACCGGCTTCTCTGCATTTGGTCTGCTGATCATGTTGCCATAATGTGTATGGAAAGTGTAACACATTCTTACTGGTTAAAGAC
GACTACCAGGTATCTAACTTGTTTAACATTGAGTTTGTGTGTGTGTGTGTATGTTTGTGTGTTTTGTATATTGTTTACATTTTGAGAGGT
AGCATTCTGTTTCAAATGCTTTTTGTTTTTCTGACAGTATTGTTGACTGGGTCATAACATTTTGAGCTGTGGTTTGGTGGATTTTCAATT
TTTTTTTTTAAAGGTCATTCGCTGTGCTATCTTCAAAACCTTGAGTTTGGCCCCCAATTTTTGGCATTCAAATGTTTAAAAGCTATTTAT
CTTGGTTTATACAAGTTTCCTTTCTCTTCTTTTTGTCATGGTATTCTATTTGGTCTGCAGTTTGAATGTAGAGAAAGTGGACTGATCCCC
CAAGCGTTGTCTGCCCCCACTCTTTCCTCCTTGGGTCCCGCCATTCTTTTACTGGGCAGTCGAGGGCATTGGAGGGGAAGTGACTGCCCT
CAGCCTCACTCCCTGGGGCCATGAAGAAAAGCTAAACAGTCTCATGGCATCTCAGAATAATGTTGGGTCTCCCAAGAAGAAAGGTGTAAG
AATAACGACATGGCTGATTAGGCGAGGCCAGGATAGGGCTAAGGCCAGGATTCCTGGCTGGCATCCAGTCACCCCTTCTCCCATCCTTCC
CCCTCTTCTTCCACAAGTCCGCAGCCGAGACACTGTAGTCTCCCAGCCACAGTGATGAGTGCCCTGGAGACTCCACTGACCTCTAGATGA
AGGCCCCTGGCCCTGGTTCCTGTTAATTAACCTCTGGGTCTTTGAGTCCCCCAGCACAAACTTCTTTCCTGTACCCTGCGGCTTGGGGTC
ACAGGGCATGCCGGGAAGCCACAGCTGAGGGGCGCAGACTGAAGCAGTGCTCCACCTCTCCTTCTTTAGCTCAGGGGTTGCTGGTCTGTG
GCAGGCGCCACGAGTGGCCCCTGTGGCTGTTCTCAGTGGCAGTCTCTTAAGTTCCCACCACAGGCAGCTCTTTATCCCCTCTCCCTACTT
GACTCTTTCTCTTGCCTGTGCTTTTGGCCTCAAACAGGCCTGCTGGTAGCGCTCAGGGCGTGAGGCTACACTCCTGCCCTGCCTTTCCTG
TCTTCATGGTCTGCCAGGGCATACCTTGGGGAGGTGGACCAAAGACCCAGGACTTTTTGCAGTAGCCAGTCCTACCCCCCAGTTGTCTTT
TTACCAATTCAGGGTGGGAGAGAAAACTGCAGCACCCCAGCATGTGAGTTACTCAGGTGTTGGGGGCTAGAAGGGACAGTGCGTTTAAAC
AACACTCAGAGCTCTGGCCTTAAACCTGTGGCCCCCCAAGTCTAGGAGCCTCATCTCTTCCTGGCAGTCATGCGGGCAGGAGGTCCTGAA
AGGGAAAACCCATTCAGACAACTGTTCCCCAATCTACCAGCCATCTGCAGGGGTCAGTGACCGTGGCCCTCTCCCTCCTCTAGAATGTGC
CACTTATGAAGAGTGCCCCATGGGGAAAAGGAGACTCAGCTGTCCCTTGGCAGCTTGTGCCAGTATCCCAGGGCAGAAGTTTCCACAGGA
GCCTCTTGCCCTTGCGCAGAGCCACTGTGAGAGGCGGTGGGAGCCAACACCCTTGGGGGAGGGGGCAGTACTGCTCGGCACATCCCAGCA
TCAGGTCAGATCATTGAAATTAAAAAATGTGAATTAAGTTCATATCCACCTTTTGGGGAAGCAGGACAAACCACCACCCCACCAAGTGTG
TGACTTCTCCATATCCCACTGCAGTTTCCATTTTTTAAATGGGAATTTTCAATCCCCTGTGCTTGTCTAACGTCTGCTTTAAAAAGTTTG

>34674_34674_5_GRB7-PIP4K2B_GRB7_chr17_37898969_ENST00000394211_PIP4K2B_chr17_36927525_ENST00000269554_length(amino acids)=249AA_BP=19
MELDLSPPHLSSSPEDLCPAPGTPPGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSA
RGLLPRDASRPHFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVD

--------------------------------------------------------------
>34674_34674_6_GRB7-PIP4K2B_GRB7_chr17_37898969_ENST00000445327_PIP4K2B_chr17_36927525_ENST00000269554_length(transcript)=4956nt_BP=510nt
TGCGGGCTGCGGGGAGATGTGGGGAGGGCCCCCTCCACTTTGGAGGGCAGTGAAGGAGAGGGATCCTCTAAATTGTCGAGGCTTCATCTC
TCCAGATTGTATGCCCTTCTCAGCAACACCGCCTCCGGCCCTCCGATGGGAAAGTGGAGGCCGGGACAAGGGCACACAACTGGTTCCGTT
AAGCCCCTCTCTTGCTCAGACGCCATGGAGCTGGATCTGTCTCCACCTCATCTTAGCAGCTCTCCGGAAGACCTTTGCCCAGCCCCTGGG
ACCCCTCCTGGGACTCCCCGGCCCCCTGATACCCCTCTGCCTGAGGAGGTAAAGAGGTCCCAGCCTCTCCTCATCCCAACCACCGGCAGG
AAACTTCGAGAGGAGGAGAGGCGTGCCACCTCCCTCCCCTCTATCCCCAACCCCTTCCCTGAGCTCTGCAGTCCTCCCTCACAGAGCCCA
ATTCTCGGGGGCCCCTCCAGTGCAAGGGGGCTGCTCCCCCGCGATGCCAGCCGCCCCCATTTCTTGGCACAGCTGAAGATCATGGACTAC
AGCCTGCTGGTGGGCATCCACGACGTGGACCGGGCAGAGCAGGAGGAGATGGAGGTGGAGGAGCGGGCAGAGGACGAGGAGTGTGAGAAT
GATGGGGTGGGTGGCAACCTACTCTGCTCCTATGGCACACCTCCGGACAGCCCTGGCAACCTCCTCAGCTTTCCTCGGTTCTTTGGTCCT
GGGGAATTCGACCCCTCTGTTGACGTCTATGCCATGAAAAGCCATGAAAGTTCCCCCAAGAAGGAGGTGTATTTCATGGCCATCATTGAT
ATCCTCACGCCATACGATACAAAGAAGAAAGCTGCACATGCTGCCAAAACGGTGAAACACGGGGCAGGGGCCGAGATCTCGACTGTGAAC
CCTGAGCAGTACTCCAAACGCTTCAACGAGTTTATGTCCAACATCCTGACGTAGTTCTCTTCTACCTTCAGCCAGAGCCAGAGAGCTGGA
TATGGGGTCGGGGATCGGGAGTTAGGGAGAAGGGTGTATTTGGGCTAGATGGGAGGGTGGGAGCAGAGTCGGGTTTGGGAGGGCTTTAGC
AATGAGACTGCAGCCTGTGACACCGAAAGAGACTTTAGCTGAAGAGGAGGGGGATGTGCTGTGTGTGCACCTGCTCACAGGATGTAACCC
CACCTTCTGCTTACCCTTGATTTTTTCTCCCCATTTGACACCCAGGTTAAAAAGGGGTTCCCTTTTTGGTACCTTGTAACCTTTTAAGAT
ACCTTGGGGCTAGAGATGACTTCGTGGGTTTATTTGGGTTTTGTTTCTGAAATTTCATTGCTCCAGGTTTGCTATTTATAATCATATTTC
ATCAGCCTACCCACCCTCCCCATCTTTGCTGAGCTCTCAGTTCCCTTCAATTAAAGAGATACCCGGTAGACCCAGCACAAGGGTCCTTCC
AGAACCAAGTGCTATGGATGCCAGATTGGAGAGGTCAGACACCTCGCCCTGCTGCATTTGCTCTTGTCTGGATTAACTTTGTAATTTATG
GAGTATTGTGCACAACTTCCTCCACCTTTCCCTTGGATTCAAGTGAAAACTGTTGCATTATTCCTCCATCCTGTCTGGAATACACCAGGT
CAACACCAGAGATCTCAGATCAGAATCAGAGATCTCAGAGGGGAATAAGTTCATCCTCATGGGATGGTGAGGGGCAGGAAAGCGGCTGGG
CTCTTGGACACCTGGTTCTCAGAGAACCCTGTGATGATCACCCAAGCCCCAGGCTGTCTTAGCCCCTGGAGTTCAGAAGTCCTCTCTGTA
AAGCCTGCCTCCCACTAGGTCAAGAGGAACTAGAGTACCTTTGGATTTATCAGGACCCTCATGTTTAAATGGTTATTTCCCTTTGGGAAA
ACTTCAGAAACTGATGTATCAAATGAGGCCCTGTGCCCTCGATCTATTTCCTTCTTCCTTCTGACCTCCTCCCAGGCACTCTTACTTCTA
GCCGAACTCTTAGCTCTGGGCAGATCTCCAAGCGCCTGGAGTGCTTTTTAGCAGAGACACCTCGTTAAGCTCCGGGATGACCTTGTAGGA
GATCTGTCTCCCTGTGCCTGGAGAGTTACAGCCAGCAAGGTGCCCCCATCTTAGAGTGTGGTGTCCAAACGTGAGGTGGCTTCCTAGTTA
CATGAGGATGTGATCCAGGAAATCCAGTTTGGAGGCTTGATGTGGGTTTTGACCTGGCCTCAGCCTTGGGGCTGTTTTTCCTTGTTGCCC
CGCTCTAGACTTTTAGCAGATCTGCAGCCCACAGGCTTTTTTGGAAGGAGTGGCTTCCTGCAGGTGTTCCACCTGCCTTCGGAGCCTGCC
ACCCAGGCCCTCAGAACTGAGCCACAGGCTGCTCTGGCCAGGAGAGAAACAGCTCTGTTGTTCTGCATTGGGGGAGGTACATTCCTGCAT
CTTCTCACCCCCTCAACCAGGAACTGGGGATTTGGGATGAGATATGGTCAGACTTGTAGATAACCCCAAAGATGTGAAGATCGCTTGTGA
AACCATTTTGAATGAATAGATTGGTTTCCTGTGGCTCCCTCCAAACCTGGCCAAGCCCAGCTTCCGAAGCAGGAACCAGCACTGTCTCTG
TGCCTGACTCACAGCATATAGGTCAGGAAAGAATGGAGACGGCATTCTTGGACTTCACTGGGGCTGCTGGATTGGATGGGAAACCTTCTG
GAAGAGGCAGATGGGGGTCAAACCACTGCCTTGGCCCCAGGAAGGGGCCATAGGTAGGTCTGAACAACTGCCGCAAGACCACTACATGAC
TTAGGGAACTTGAAACCAACTGGCTCATGGAGAAAACAAATTTGACTTGGGAAAGGGATTATGTAGGAATAATGTTTGGACTTGATTTCC
CCACGTCATAATGAAGAATGGAAGTTTGGATCTGCTCCTCGTCAGGCGCAGCATCTCTGAAGCTTGGAAAGCTGTCTTCCAGCAGCCTCC
GTGGCCTCGGGTTCCTACCGGCTTCTCTGCATTTGGTCTGCTGATCATGTTGCCATAATGTGTATGGAAAGTGTAACACATTCTTACTGG
TTAAAGACGACTACCAGGTATCTAACTTGTTTAACATTGAGTTTGTGTGTGTGTGTGTATGTTTGTGTGTTTTGTATATTGTTTACATTT
TGAGAGGTAGCATTCTGTTTCAAATGCTTTTTGTTTTTCTGACAGTATTGTTGACTGGGTCATAACATTTTGAGCTGTGGTTTGGTGGAT
TTTCAATTTTTTTTTTTAAAGGTCATTCGCTGTGCTATCTTCAAAACCTTGAGTTTGGCCCCCAATTTTTGGCATTCAAATGTTTAAAAG
CTATTTATCTTGGTTTATACAAGTTTCCTTTCTCTTCTTTTTGTCATGGTATTCTATTTGGTCTGCAGTTTGAATGTAGAGAAAGTGGAC
TGATCCCCCAAGCGTTGTCTGCCCCCACTCTTTCCTCCTTGGGTCCCGCCATTCTTTTACTGGGCAGTCGAGGGCATTGGAGGGGAAGTG
ACTGCCCTCAGCCTCACTCCCTGGGGCCATGAAGAAAAGCTAAACAGTCTCATGGCATCTCAGAATAATGTTGGGTCTCCCAAGAAGAAA
GGTGTAAGAATAACGACATGGCTGATTAGGCGAGGCCAGGATAGGGCTAAGGCCAGGATTCCTGGCTGGCATCCAGTCACCCCTTCTCCC
ATCCTTCCCCCTCTTCTTCCACAAGTCCGCAGCCGAGACACTGTAGTCTCCCAGCCACAGTGATGAGTGCCCTGGAGACTCCACTGACCT
CTAGATGAAGGCCCCTGGCCCTGGTTCCTGTTAATTAACCTCTGGGTCTTTGAGTCCCCCAGCACAAACTTCTTTCCTGTACCCTGCGGC
TTGGGGTCACAGGGCATGCCGGGAAGCCACAGCTGAGGGGCGCAGACTGAAGCAGTGCTCCACCTCTCCTTCTTTAGCTCAGGGGTTGCT
GGTCTGTGGCAGGCGCCACGAGTGGCCCCTGTGGCTGTTCTCAGTGGCAGTCTCTTAAGTTCCCACCACAGGCAGCTCTTTATCCCCTCT
CCCTACTTGACTCTTTCTCTTGCCTGTGCTTTTGGCCTCAAACAGGCCTGCTGGTAGCGCTCAGGGCGTGAGGCTACACTCCTGCCCTGC
CTTTCCTGTCTTCATGGTCTGCCAGGGCATACCTTGGGGAGGTGGACCAAAGACCCAGGACTTTTTGCAGTAGCCAGTCCTACCCCCCAG
TTGTCTTTTTACCAATTCAGGGTGGGAGAGAAAACTGCAGCACCCCAGCATGTGAGTTACTCAGGTGTTGGGGGCTAGAAGGGACAGTGC
GTTTAAACAACACTCAGAGCTCTGGCCTTAAACCTGTGGCCCCCCAAGTCTAGGAGCCTCATCTCTTCCTGGCAGTCATGCGGGCAGGAG
GTCCTGAAAGGGAAAACCCATTCAGACAACTGTTCCCCAATCTACCAGCCATCTGCAGGGGTCAGTGACCGTGGCCCTCTCCCTCCTCTA
GAATGTGCCACTTATGAAGAGTGCCCCATGGGGAAAAGGAGACTCAGCTGTCCCTTGGCAGCTTGTGCCAGTATCCCAGGGCAGAAGTTT
CCACAGGAGCCTCTTGCCCTTGCGCAGAGCCACTGTGAGAGGCGGTGGGAGCCAACACCCTTGGGGGAGGGGGCAGTACTGCTCGGCACA
TCCCAGCATCAGGTCAGATCATTGAAATTAAAAAATGTGAATTAAGTTCATATCCACCTTTTGGGGAAGCAGGACAAACCACCACCCCAC
CAAGTGTGTGACTTCTCCATATCCCACTGCAGTTTCCATTTTTTAAATGGGAATTTTCAATCCCCTGTGCTTGTCTAACGTCTGCTTTAA
AAAGTTTGAGACCCTGTTACTGTTTGAAAATGCATGCATGTTACGATGAATCTCCAACCTGAGGAAAAAAATAAAACTCAAAAAGCTTTG

>34674_34674_6_GRB7-PIP4K2B_GRB7_chr17_37898969_ENST00000445327_PIP4K2B_chr17_36927525_ENST00000269554_length(amino acids)=315AA_BP=85
MRGDVGRAPSTLEGSEGEGSSKLSRLHLSRLYALLSNTASGPPMGKWRPGQGHTTGSVKPLSCSDAMELDLSPPHLSSSPEDLCPAPGTP
PGTPRPPDTPLPEEVKRSQPLLIPTTGRKLREEERRATSLPSIPNPFPELCSPPSQSPILGGPSSARGLLPRDASRPHFLAQLKIMDYSL
LVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDIL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for GRB7-PIP4K2B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GRB7-PIP4K2B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for GRB7-PIP4K2B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source